PMID
int64 35.7M
36.4M
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36,293,206
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immunomodulatori effect human lactoferrin toll like receptor express therapeut approach keratoconus keratoconus kc corneal disord whose etiolog share close relationship lactoferrin ltf dysregul toll like receptor tlr overexpress studi show two import biomark clinic molecular interrel increas knowledg kc pathophysiolog open door futur therapi prospect clinic studi serum tear ltf concentr quantifi kc patient control correl analysi multipl blood tear immunoinflammatori mediat kc associ tomograph paramet perform vitro studi use hek blue tm htlr cell cultur also conduct determin express function tlr influenc ltf treatment result ltf decreas observ kc patient compar control p lt evidenc strong correl tlr overexpress system ocular surfac level inflammatori mediat upregul kc sever stimul cell cultur tlr express decreas use mgml ltf level secret embryon alkalin phosphatas seap interleukin il also reduc supernat ltf treatment conclus dysregul ltf tlr ocular surfac kc patient contribut kc sever maintain detriment chronic immun inflammatori state immunomodulatori properti ltf tlr express suggest potenti therapeut approach kc
|
D007640
|
T047
|
36,293,205
|
influenc prenat exposur quetiapin fumar develop dopaminerg neuron ventral midbrain mous embryo effect second generat antipsychot prenat neurodevelop apoptot neurodegener postnat development delay poor investig even standard dose use quetiapin fumar qepf pregnant women might detriment fetal develop use primari mous embryon neuron evalu disrupt morphogenesi differenti ventral midbrain vm neuron exposur qepf dopaminerg vm neuron deliber target due role cognit motor activ behavior result reveal exposur qepf earli brain develop decreas effect dopaminerg lineag relat gene tyrosin hydroxylas th dopamin receptor drd dopamin transport dat lim homeobox transcript factor alfa lmxa cell adhes molecul l chl senesc dopaminerg gene pituitari homeobox pitx contrast brain deriv neurotroph factor bdnf nuclear receptor relat nurr express signific upregul interest qepf variabl effect develop non dopaminerg neuron vm optim dose qepf found insignific affect viabil neuron isol vm also instig non signific reduct adenosin triphosph format neuron popul exposur qepf earli stage brain develop could also hinder format vm structur phenotyp find could aid therapeut decis make prescrib nd generat antipsychot pregnant popul
|
D039842;D011297
|
T123;T116;T037
|
36,293,204
|
blood brain barrier disintegr growth restrict fetus brain spare effect endotheli cell blood brain barrier adher close provid tight junction tjs aim studi assess damag endotheli tjs pregnanc complic fetal growth restrict fgr circulatori central brain spare effect bs serum concentr nr subunit n methyl aspart receptor nr nucleosid diphosph kinas nme calcium bind protein b sb occludin ocln claudin cln zonula occluden protein zo placent express ocln claudin cln cln zo assess elisa signific higher serum nme concentr serum clnzo index observ fgr pregnanc bs compar fgr group without bs fgr newborn bs time like develop intraventricular hemorrhag ivh fgr infant without bs cerebroplacent ratio cpr allow predict ivh growth restrict fetus signific lower placent cln express observ fgr group bs postnat develop ivh compar growth restrict infant bs without ivh sign pregnanc complic fgr bs associ destabil fetal blood brain barrier ivh newborn reflect inhibit placent cln express may use marker predict ivh among growth restrict fetus
|
D001812;D042783
|
T023;T025
|
36,293,203
|
coenzym q attenu human platelet aggreg induc sar cov spike protein via reduc oxid stress vitro platelet hyperreact oxid stress import caus thrombot disord patient covid oxid stress induc excess generat reactiv oxygen speci ros could increas platelet function risk thrombus format coenzym q coq exhibit strong antioxid activ anti platelet effect howev effect mechan coq attenu platelet aggreg induc spike protein never studi studi aim investig whether sar cov spike protein potenti human platelet function via ros signal protect effect coq vitro use seri platelet function assay found spike protein potenti platelet aggreg oxid stress ros level mitochondri membran potenti depolar lipid damag level mda iso pgf vitro furthermor coq attenu platelet aggreg induc spike protein anti platelet mechan show coq signific decreas excess product ros induc spike protein find show protect effect coq spike protein potenti platelet aggreg probabl associ strong antioxid abil
|
D064370;D000086382
|
T123;T047;T116;T067
|
36,293,202
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integrin alpha v beta v implic cancer treatment integrin necessari cell adhes migrat posit essenti induc signal event cell surviv prolifer differenti also trigger varieti signal transduct pathway involv mediat invas metastasi squamous cell carcinoma sever recent studi demonstr regul express v integrin potent marker malign diseas patient prognosi review focus arginin glycin aspart acid rgd depend integrin v biolog role healthi human examin implic v cancer progress promot epitheli mesenchym transit emt contribut activ transform growth factor beta tgf although v crucial proper function healthi peopl also valid target cancer treatment review briefli consid aspect target v clinic via differ therapeut modal
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D039564;D009369
|
T123;T191;T116
|
36,293,201
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bioactiv lipodepsipeptid produc bacteria fungi natur product vital sourc agricultur medicin cosmet field lipodepsipeptid lpds wide group natur product distribut among live organ bacteria fungi yeast virus insect plant marin organ group compound consist lipid connect peptid abl self assembl sever differ structur shown differ biolog activ phytotox antibiot antivir antiparasit antifung antibacteri immunosuppress herbicid cytotox hemolyt activ biolog activ seem due interact plasma membran mp abl mimic architectur nativ membran interact hydrophob segment lpds also surfact properti review focus lipodepsipeptid isol fungal bacteri sourc biolog activ structur activ relationship select lpd subgroup potenti applic agricultur medicin chemic biolog character lipodepsipeptid isol last three decad find result sci finder research report critic evalu recent review deal argument also describ
|
D005658;D001688
|
T123;T121;T004
|
36,293,200
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proteom mirna profil exosom deriv myometri tissu labor women myometri contract essenti success deliveri recent studi highlight vital role tissu deriv exosom diseas diagnost prognost therapeut applic howev characterist uterin myometrium deriv exosom unclear success isol exosom myometri tissu human myometri smooth muscl cell hmsmcs human umbil vein endotheli cell huvec perform quantit liquid chromatographi tandem mass spectrometri mirna sequenc investig cargo exosom fifti two protein five mirna differenti express de term non labor term labor myometrium deriv exosom among seven protein serpin thbs mgat vim fgb fgg vwf differenti express myometri exosom tissu three mirna mir p mir p mir p target de gene top three mirna deriv hmsmcs mir b p mir p mir p huvec mir mir mir p identifi two protein gja slca exist femal blood exosom high express hmsmcs exosom also upregul labor myometrium verifi increas labor blood sampl might novel potenti biomark myometri activ proteom mirna profil exosom deriv labor myometrium reveal molecul exosom affect intercellular communic function myometrium
|
D055354;D035683
|
T026;T123;T114
|
36,293,199
|
atpb defici result elev mitochondri phosphatidylethanolamin level increas mitochondri oxid phosphoryl human hepatoma cell atpb phospholipid flippas defici patient progress famili intrahepat cholestasi type pfic pfic patient suffer sever liver diseas also present dyslipidemia includ low plasma cholesterol yet unknown etiolog show atpb knockdown hepg cell lead strong increas mitochondri oxid phosphoryl oxpho without chang glycolysi enhanc oxpho coincid elev low densiti lipoprotein receptor protein increas mitochondri fragment phosphatidylethanolamin level furthermor express phosphatidylethanolamin n methyltransferas enzym catalyz convers mitochondri deriv phosphatidylethanolamin phosphatidylcholin reduc atpb knockdown cell conclud atpb defici result elev mitochondri pe level stimul mitochondri oxpho increas oxpho lead elev ldlr level provid possibl explan reduc plasma cholesterol level pfic diseas
|
D006528;D008113
|
T191
|
36,293,198
|
identif novel nucleocapsid chimer protein inhibit hiv replic posit transcript elong factor b p tefb essenti factor induc transcript elong also negat regul cellular factor hexim previous chimer protein hexim tat ht demonstr inhibit human immunodefici virus hiv transcript studi attempt develop improv antivir protein specif bind viral rna vrna fuse ht hiv nucleocapsid nc thus synthes nc hexim tat nht hexim tat nc htn nht htn inhibit virus prolifer effect ht attenu function ht notabl nht htn inhibit infect progeni virus wherea ht effect nht htn select effect interact vrna inhibit proper packag hiv genom taken togeth result illustr novel nc fuse chimer protein nht htn display novel mechan anti hiv effect inhibit hiv transcript packag
|
D042925;D015497
|
T005;T126;T116
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36,293,197
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complex relationship hiv integras cellular partner rna virus pursuit genom miniatur tend employ cellular protein facilit replic hiv one well studi retrovirus except numer evid exploit cellular machineri reli nucleic acid protein protein protein interact apart vpr vif nef protein known regul cellular function via interact cell compon anoth viral protein integras appear crucial proper virus cell dialog differ stage viral life cycl goal review summar systemat exist data known cellular partner hiv integras role hiv life cycl
|
D019427;D015497;D009696
|
T123;T116;T005;T126;T114
|
36,293,196
|
identif mirna mediat seed storabl maiz germin stage high throughput sequenc transcriptom degradom sequenc seed storabl import trait improv grain qualiti germplasm conserv littl known regulatori mechan gene network involv microrna mirna small non code rnas regul translat accumul target mrnas mean sequenc complementar recent emerg critic regul seed germin use germin embryo two maiz inbr line signific differ seed storabl identifi mirna target gene involv identifi total previous known novel mirna mirna sequenc degradom analysi known newli predict mirna differenti express two maiz inbr line measur gene ontolog go enrich analysi combin transcriptom sequenc real time quantit polymeras chain reaction rt pcr screen confirm six pair differenti express mirna associ seed storabl along negat regulatori target gene enrich analysi suggest mirnastarget gene mediat seed storabl occur via ethylen activ signal pathway hormon synthesi signal transduct well plant organ morphogenesi result help elucid mechan mirna involv seed storabl maiz
|
D018525;D035683
|
T123;T114;T038
|
36,293,195
|
role macrophag air pollut exposur relat asthma asthma chronic inflammatori airway diseas character variabl airflow obstruct bronchial hyper respons airway inflamm chronic inflamm airway mediat mani cell type cytokin chemokin inflammatori mediat research suggest exposur air pollut negat impact asthma outcom adult pediatr popul air pollut one greatest environment risk health impact lung innat adapt defens system major pollut air particul matter pm complex compon compos element carbon heavi metal accord peopl live air pollut air qualiti level lower air qualiti guidelin suggest effect air pollut exposur asthma crucial health issu worldwid macrophag essenti recogn process inhal foreign materi pm alveolar macrophag one predomin cell type process remov inhal pm secret proinflammatori mediat lung review focus macrophag role orchestr inflammatori respons induc exposur air pollut asthma
|
D000397;D000393;D001249
|
T131;T047;T069;T080
|
36,293,194
|
drp overexpress decreas insulin content pancreat min cell mitochondri dynam bioenerget central glucos stimul insulin secret pancreat beta cell previous demonstr disturb glucos invok fission impair insulin secret compromis glucos catabol investig whether overexpress mitochondri fission regul drp min cell improv rescu insulin secret although drp overexpress slight improv trigger mechan insulin secret drp knockdown cell advers effect mitochondri metabol wildtyp min cell constitut presenc drp unexpect impair insulin content lead reduct absolut valu secret insulin coher previous studi drp overexpress muscl cell found upregul er stress relat gene bip chop hsp possibl impact insulin product min cell collect confirm import role drp energi coupl insulin secret unravel target effect drp overexpress insulin content warrant caution manipul drp diseas therapi
|
D007328;D050417
|
T125;T121;T116;T025
|
36,293,193
|
bind csl protein either co activ co repressor protect proteasom degrad induc mapk depend phosphoryl primari role notch specifi cellular ident wherebi cell respond amaz small chang notch signal activ henc dosag notch compon crucial regul central notch signal transduct csl protein togeth respect cofactor mediat activ silenc notch target gene csl protein extrem similar amongst speci regard sequenc structur notic fli homologu suppressor hairless su h stabilis transcript complex use specif transgen fli line hela rbpj ko cell provid evid su h subject proteasom degrad half life two hour protect bind co repressor hairless co activ notch moreov su h stabil control mapk depend phosphoryl match earlier data rbpj human cell homolog murin human rbpj protein howev larg resist degrad system mutat presumpt protein contact site howev sensitis rbpj proteolysi overal data highlight similar regul csl protein stabil across speci impli turnov csl protein may conserv mean regul notch signal output direct level transcript
|
D029721
|
T123;T116
|
36,293,192
|
plasma extracellular vesicl play role immun system modul minim hepat encephalopathi minim hepat encephalopathi mhe associ chang immun system includ increas pro inflammatori environ alter differenti cd lymphocyt mechan remain unknown chang extracellular vesicl ev cargo includ protein mirna could play main role mediat immun system chang associ mhe aim assess whether plasma ev mhe patient play role induc pro inflammatori environ alter differenti cd lymphocyt subtyp mhe patient character mirna protein cargo plasma ev cirrhot patient without mhe control cd cell control cultur plasma ev three group studi cytokin releas differenti cd cell subtyp assess plasma ev mhe patient alter mirna protein content enrich inflammatori factor compar control patient without mhe ev mhe patient modul express pro inflammatori il il tnf anti inflammatori tgf cultur cd lymphocyt increas proport th follicular treg cell activ th cell conclus plasma ev could play import role induct immun chang observ mhe
|
D006501;D000067128;D035683
|
T026;T123;T047;T114
|
36,293,191
|
punicalagin protect develop methotrex induc hepatotox mice via activ nrf signal decreas oxid stress inflamm cell death despit effect treat inflammatori diseas various malign methotrex mtx well known caus hepatotox involv increas oxid stress inflamm limit clinic use herein look effect punicalagin pu polyphenol molecul varieti health promot attribut mtx induc hepatotox mice pu mgkgday given oral mice day singl dose mtx mgkg inject intraperiton ip day mtx induc liver damag demonstr remark higher transaminas alt ast alp ldh well signific histolog alter hepat tissu mtx inject mice also demonstr increas hepat oxid stress marker includ malondialdehyd mda nitric oxid concord drop glutathion gsh content superoxid dismutas sod catalas cat activ pu signific attenu mtx induc serum transaminas alp ldh elev hepat oxid stress measur boost antioxid defens liver moreov liver mtx treat mice show increas nf b p express pro inflammatori cytokin il tnf level pro apoptot protein caspas bax express wherea bcl nrf express reduc attenu pu treatment collect pu inhibit oxid damag inflamm apoptosi upregul nrf liver mtx induc mice thus find suggest pu may great therapeut potenti prevent mtx induc hepatotox pend explor upcom studi
|
D051267;D056486
|
T123;T047;T116;T037
|
36,293,190
|
assess cell immun kidney transplant recipi absent antibodi product rd dose mrna vaccin vulner popul kidney transplant recipi ktrs low respond covid vaccin specif immun surveil need interferon gamma ifn releas assay igra effect assess cell mediat immun assess sar cov direct cell respons ktrs absent antibodi product third dose mrna vaccin use two differ igra cohort ktrs activ follow receiv third dose mrna vaccin evalu humor immun sar cov seroneg patient test two commerci igra sd biosensor euroimmun patient one three sampl posit igra euroimmun sd biosensor respect overal agreement two assay addit multivari linear regress analysi show statist signific associ ifn concentr independ variabl analyz age gender year sinc transplant total lymphocyt cellsmcl cd cellsmcl cd cd cellsmcl cd cd cellsmcl cd cellsmcl cd cdcd cellsmcl p gt vulner set assess cellular immun respons complement humor respons may advantag sinc two commerci igra show good agreement negat sampl three discord sampl highlight need investig
|
D016030;D000086382
|
T061;T047;T067
|
36,293,189
|
anion exchang chromatographi servic gene therapi baselin separ fullempti adeno associ virus capsid screen condit step gradient elut mode gene therapi open unpreced opportun novel therapeut approach base concept rescu function mutat co express correct gene allow biolog function restor requir use viral vector ensur proper deliveri therapeut gene context recombin adeno associ virus raav wide use vector biomanufactur process requir insert therapeut gene raav full capsid howev percentag raav contain desir gene empti capsid well part fill capsid might also produc potenti impact effici therapi therefor determin raav capsid fullempti ratio need monitor ensur consist product qualiti efficaci anion exchang chromatographi aex serv need contribut thorough aex method develop includ mobil phase stationari phase gradient condit highlight potenti support gene therapi take advantag fact viral capsid follow onoff retent behavior applic step gradient approach raav serotyp raav allow unpreced separ raav fullempti capsid resolut gain compar resolut obtain fulli optim linear gradient final develop analyt approach allow precis accur baselin separ quantif full empti raav capsid potenti appli high throughput qualiti control qc method
|
D000229;D002213
|
T005;T017
|
36,293,188
|
ubiquitin proteasom gene signatur ependymoma molecular subtyp ubiquitin proteasom system up critic import cellular homeostasi affect virtual key function normal neoplast cell current comprehens review role up ependymoma epn brain tumor lack may provid valuabl new inform cellular network specif differ epn subtyp reveal futur therapeut target review public avail epn gene transcript dataset encod compon up pathway reactom analysi data reveal gene pathway abl distinguish differ epn subtyp high signific identifi differenti transcript sever gene encod ubiquitin e conjugas associ epn subtyp express e conjugas gene ubec ube ubei elev stepnrela subtyp ubec ube enzym associ ubiquitin ligas anaphas promot complex apcc regul degrad substrat associ cell cycl progress wherea ubei sumo conjug enzym addit elev stepnrela gene e ligas histon deacetylas hdac f box cullin ring ligas adaptor fbx cluster analysi demonstr sever gene encod e ligas substrat adaptor epn subtyp specif genet marker signific reactom pathway associ differenti express gene e ligas adaptor includ antigen present neddyl sumoyl apcc complex analysi provid sever up associ factor may attract marker futur therapeut target subtyp specif treatment epn patient
|
D004806;D001932
|
T191
|
36,293,187
|
polytop rearrang govern stereochemistri bicycl oxim ether synthesi present studi four substitut oxim quinuclidin one synthes use appropri substitut hydroxylamin hydrochlorid order perform reaction solvent mixtur e z product yield use mechanochem microwav synthesi obtain pure e oxim almost case convers oxim ether complet reaction monitor atr spectroscopi ratio e z oxim ether deduc h nmr data sever reaction rapid min convers stereospecif investig reaction mechan full conform analys reaction intermedi perform lowest energi conform determin conform differ spatial arrang around nitrogen atom amino group correct orient reaction occur calcul standard gibb energi format agreement experiment obtain ratio e z isom work show altern classic synthesi substitut oxim ether precursor highlight fast reaction rate stereoselect microwav synthesi well green aspect mechanochemistri
|
D010091;D004986
|
T121;T109
|
36,293,186
|
fine tune reactiv n contain naphthol analogu hydroxyquinolin hydroxyisoquinolin n contain naphthol analogu test modifi mannich reaction mr case hydroxyquinolin outcom attempt mannich reaction strong influenc amin compon aminoalkyl substrat reagent naphthaldehyd n benzylmethylamin led isol diol regard stabilis water adduct ortho quinon methid qm format ascrib presenc hydroxid ion relat higher concentr generat bulki basic amin compon decreas nucleophil classic mannich base isol singl product amin compon replac morpholin featur nucleophil rather basic charact appli reaction condit start isom substrat hydroxyisoquinolin independ nucleophil methanol morpholin besid format classic mannich base nucleophil attack posit one heterocycl substrat also observ dft analysi acceptor molecular orbit potenti electrophil compon thermodynam assum possibl transform demonstr regioselect addit feasibl process investig heterocycl skeleton dft model studi also suggest besid steric bulk orbit control electron properti aryl group origin aldehyd compon strong influenc ratio nmr monitor interconvers c substitut hydroxyisoquinolin classic mannich base form multistep reaction sequenc basi dft analysi thermodynam altern pathway reaction mechan propos ration characterist substrat control interconvers
|
D008352;D009284
|
T130;T109
|
36,293,185
|
glucocorticoid regul kinas camki central amygdala control anxieti like behavior mice express calciumcalmodulin depend protein kinas gamma encod camkg gene depend activ glucocorticoid receptor gr strong regul stress sinc camkg primarili express neuron cell limbic system brain hypothes could involv signal mechan underli adapt maladapt respons stress find restraint induc stress gr agonist dexamethason robust increas express camkg neuron amygdalar nuclei mous brain assess function role camkg express perform viral induc knock transcript mice bilater amygdala specif camkg knock show increas anxieti like behavior light dark box increas freez behavior fear condit normal spatial work memori explor maze thus confirm camkg neuron specif gr regul transcript show specif involv behavior relat anxieti well respons condit avers stimuli
|
D005938;D066274
|
T125;T039;T023;T109
|
36,293,184
|
cancer stem cell hepatocellular carcinoma intrins extrins molecular mechan stem regul hepatocellular carcinoma hcc remain predomin type liver cancer extrem poor prognosi due late diagnosi high recurr rate one culprit hcc recurr metastasi exist cancer stem cell cscs small subset cancer cell possess robust stem cell properti within tumor cscs play crucial role tumor heterogen constitut tumorigenesi tumor relaps metastasi resist anti cancer therapi elucid cscs maintain stem featur essenti develop cscs base therapi review summar present knowledg intrins molecul signal pathway involv hepat cscs especi csc surfac marker associ signal regul stem characterist heterogen subpopul within csc pool addit recapitul effect crucial extrins cellular compon tumor microenviron includ stromal cell immun cell modul hepat cscs final synops current valuabl cscs target therapi strategi base intervent intrins extrins molecular mechan hope shed light better clinic manag hcc patient
|
D006528;D008113
|
T191
|
36,293,183
|
candesartan activ ppar target gene earli gestat trophoblast angiotensin ii receptor blocker common use treat hypertens women childbear age fetotox effect drug second third trimest pregnanc well document possibl impact placenta develop earli gestat unknown candesartan member group also act peroxisom prolifer activ receptor gamma ppar agonist key regul shown import placent develop previous shown trophoblast express candesartan target receptor angiotensin ii type receptor agtr studi investig possibl role candesartan trophoblast ppar hallmark target gene earli gestat candesartan affect ppar protein express nuclear transloc ppar mimic extravil trophoblast evt cytotrophoblastsyncytiotrophoblast ctbsct respons candesartan use trophoblast cell model bewo ctbsct sghpl evt cell well placent explant vitro rt qpcr analysi show effect candesartan treatment ppar target gene bewo sghpl cell treatment posit control rosiglitazon anoth ppar agonist led decreas express lep pparg bewo cell increas express pparg sghpl cell previous data show earli gestat placent agtr express fetal myofibroblast cam assay agtr stimul angiotensin ii show increas plant vessel outgrowth result suggest candesartan negat affect ppar target gene human trophoblast like candesartan matern serum may first act fetal placent agtr influenc angiogenesi placenta warrant research
|
D014327;D047495
|
T018;T116;T192
|
36,293,182
|
role micronutri gut microbiota deriv metabolit covid recoveri balanc vari diet provid divers benefici effect health adequ micronutri avail gut microbiom homeostasi besid particip biochem process cofactor coenzym vitamin miner immunoregulatori function meanwhil gut microbiota metabolit coordin direct indirect cell respons interact host receptor malnourish crucial risk factor sever patholog involv coronavirus diseas pandem report pandem caus signific declin worldwid popul especi chronic diseas reduc physic activ elder age diet gut microbiota composit probabl caus suscept supplement play role reestablish microbi homeostasi improv immun respons coronavirus diseas infect recoveri studi review role micronutri microbiom risk infect sever diseas coronavirus diseas sequela
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D000069196;D000086382
|
T067;T047;T007;T001
|
36,293,181
|
repurpos sglt inhibitor target age avail evid molecular mechan calor restrict promot longev multipl anim model compound modul nutrient sens pathway suggest reproduc part benefici effect calor restrict age howev none common studi calor restrict mimet actual produc decreas calori sodium glucos cotransport inhibitor sglt class drug lower glucos promot elimin urin thus induc net loss calori effect promot metabol shift system level foster keton fatti acid util glucos altern substrat accompani modul major nutrient sens pathway held drive age eg mtor inflammasom overal resembl major featur calor restrict addit preliminari experiment data suggest sglt might also intrins activ independ system effect inhibit cellular senesc consist evid preclin clinic studi also suggest mark abil sglt amelior low grade inflamm human relev driver age common refer inflammag consid also amount data clinic trial observ studi meta analys suggest tangibl effect age relat outcom cardiovascular diseas heart failur kidney diseas caus mortal also patient without diabet propos framework least part benefit provid sglt mediat abil blunt driver age support postul synthes avail data relat effect class anim model healthspan lifespan select molecular pillar age preclin model biomark age especi inflammag human covid relat outcom burden evid might prompt design studi test potenti employ class anti age drug
|
D000077203;D003924;D000086382
|
T121;T047;T067;T109
|
36,293,180
|
prmt inhibitor sgc enhanc doxorubicin induc dna damag cytotox protein arginin methyltransferas prmt regul various cellular respons includ gene express cell migrat stress respons stem studi investig biolog role prmt cell cycl progress dna damag respons ddr inhibit prmt activ either sgc treatment specif sirna transfect suppress prmt caus cell cycl arrest g phase result stabil subsequ accumul p protein addit prmt activ close associ dna repair pathway includ homolog recombin non homolog end join interest sgc combin doxorubicin led synergist increas dna damag cytotox mcf cell taken togeth data demonstr prmt critic modul cell growth ddr indic promis target cancer treatment
|
D011484;D004249
|
T123;T126;T116;T049
|
36,293,179
|
time seri transcriptom analysi reveal molecular profil diapaus termin induc long photoperiod high temperatur chilo suppressali surviv adapt season chang challeng insect mani temper insect rice stem borer chilo suppressali overcom advers situat enter diapaus wherein develop chang dynam occur metabol activ suppress photoperiod temperatur act major environment stimuli diapaus howev physiolog molecular mechan interpret ecolog relev environment cue ontogenet develop diapaus termin poor understood use genom wide high throughput rna sequenc examin pattern gene express diapaus termin c sup p ressali major shift biolog process pathway includ metabol environment inform transmiss endocrin signal observ across diapaus termin base represent analysi short time seri express miner gene set enrich analysi mani new pathway identifi diapaus termin includ circadian rhythm mapk signal wnt signal ras signal togeth previous report pathway includ ecdysteroid juvenil hormon insulininsulin like signal result show converg biolog process molecular pathway diapaus termin share across differ insect speci provid comprehens roadmap better understand diapaus termin c suppressali
|
D009036;D000074767;D061385
|
T121;T040;T204
|
36,293,178
|
dynam regul mitochondri ca hippocamp neuron neuron mitochondria studi extens role health diseas rule govern calcium regul mitochondria remain somewhat vagu present studi use cultur rat hippocamp neuron transfect mtrcamp mitochondri calcium sensor investig effect cytosol calcium surg dynam mitochondri calcium ca cytosol calcium ca c measur use high affin sensor fluo record two type calcium event local global one local event limit small section dendrit presum caus local synapt activ global event associ network burst extend throughout imag dendrit case cytosol surg follow delay rise ca global event rise last longer observ mitochondri cluster end descend part global event ca still high global event accompani short rather high ca surg call spikelet present complet decay cytosol event case local event select short term respons limit part mitochondri cluster locat direct center ca c activ fade quick respons neighbor region rare observ caffein recruit ryanodin receptor suppli calcium mitochondria carbonyl cyanid chlorophenyl hydrazin cccp mitochondri uncoupl could affect ca global local event construct comput model simul fundament role mitochondria restrict calcium signal within narrow rang synaps prevent diffus adjac region dendrit result indic local cytoplasm mitochondri calcium concentr high correl reflect key role signal pathway connect postsynapt membran local mitochondri cluster
|
D002118;D019837
|
T123;T121;T116;T192;T196
|
36,293,177
|
hypertens relat obes pathogenesi characterist factor control world health organ refer obes abnorm excess fat accumul present health risk obes first design diseas sinc cost burden diseas wit worrisom increas obes hypertens close interrel abdomin obes interfer endocrin immun system carri greater risk insulin resist diabet hypertens cardiovascular diseas mani factor interplay obes hypertens includ hemodynam alter oxid stress renal injuri hyperinsulinemia insulin resist sleep apnea syndrom leptin melanocortin pathway genet epigenet mitochondri factor also play major role measur blood pressur obes patient requir adapt cuff search secondari caus necessari higher threshold general popul lifestyl modif diet exercis often enough control obes far bariatr surgeri constitut reliabl method achiev weight loss nonetheless emerg new agent semaglutid tirzepatid offer promis altern final sever molecular pathway activ explor signific extend treatment option avail
|
D007333;D006973
|
T047;T046
|
36,293,176
|
interplay gut microbiota parkinson diseas implic diagnosi treatment bidirect interact gut microbiota gm central nervous system call gut microbiota brain axi gmba deepli affect brain function import impact develop neurodegen diseas parkinson diseas pd gastrointestin symptom often preced onset motor non motor manifest alter gm composit accompani diseas pathogenesi sever studi conduct unravel role dysbiosi intestin permeabl pd onset progress therapeut diagnost applic gm modifi approach remain fulli elucid brief introduct involv gmba diseas present evid gm alter leaki gut pd patient accord data review potenti gm base signatur serv diseas biomark highlight emerg role probiot prebiot antibiot dietari intervent fecal microbiota transplant support therapeut approach pd final analyz mutual influenc common prescrib pd medic gut microbiota offer insight involv also nasal oral microbiota pd patholog thus provid comprehens date overview role microbi featur diseas diagnosi treatment
|
D000069196;D010300
|
T047;T007;T001
|
36,293,175
|
brain protein acyl system respond seizur rat model ptz induc epilepsi abnorm energi expenditur seizur metabol regul post translat protein acyl suggest acyl therapeut target epilepsi goal character interplay brain acyl system compon chang seizur rat model pentylenetetrazol ptz induc epilepsi quantifi acyl cerebr cortex protein level nad express nad depend deacylas sirt sirt sirt activ acyl coa producingnad util complex oxoacid dehydrogenas compar control group acyl site protein found differ signific seizur six protein involv glycolysi energi metabol compar singl chronic seizur reveal signific differ acyl pyruv dehydrogenas activ sirt express nad contrari express sirt sirt activ oxoglutar dehydrogenas ogdh decreas chronic seizur vs singl seizur negat correl protein succinylationglutaryl sirt express posit correl protein acetyl sirt express shown find unravel involv sirt ogdh metabol adapt seizur protein acyl consist known neuroprotect role sirt contribut ogdh glugaba balanc perturb epilepsi
|
D056566;D004827
|
T033;T047;T126;T116
|
36,293,174
|
identif character piwi interact rnas earli testicular develop yak normal testicular develop play crucial role male reproduct precondit spermatogenesi piwi interact rnas pirna novel noncod rnas express anim germ cell form complex piwi famili protein involv germ cell develop differenti spermatogenesi howev chang pirna express profil earli testicular develop yak investig studi use small rna sequenc evalu differ potenti function pirna express profil month old yak testi tissu differenti express analysi found differenti express pirna vs vs vs respect found common differenti express pirna three group addit function enrich analysi differenti express pirna target gene indic relat testicular develop spermatogenesi final detect express piwi protein famili yak testi differ development stage found piwil piwil piwil piwil high express month old yak testi almost express month old yak testi conclus studi summar chang pirna express pattern earli develop yak testi provid new clue regulatori role pirna yak testi
|
D013091;D013737
|
T023;T043
|
36,293,173
|
bind glycerol human galectin expand stabil modul function glycerol seen biolog system intermedi lipid metabol recent year glycerol report act chemic chaperon correct conform protein investig role glycerol galectin gal thermal shift cd assay show thermal stabil gal increas glycerol concentr littl secondari structur chang induc glycerol addit glycerol inhibit gal mediat erythrocyt agglutin also solv crystal structur human gal complex glycerol two differ condit glycerol bind carbohydr recognit bind site gal indic glycerol small ligand gal surpris glycerol bind new pocket near n terminus gal great reduc flexibl improv stabil region moreov overexpress gal decreas intracellular triglycerid level increas mrna express aquaporin aqp hela cell incub glycerol find indic gal might regul glycerol metabol overal result human gal rais perspect systemat explor far unrecogn phenomenon gal glycerol metabol
|
D005990;D020346
|
T123;T121;T116;T109
|
36,293,172
|
cathepsin inhibit suppress experiment system lupus erythematosus associ pulmonari arteri remodel patient system lupus erythematosus sle associ pulmonari arteri hypnertens pah receiv target therapi pah decreas pulmonari arteri systol pressur signific prolong surviv cystein cathepsin proteas play critic role progress cardiovascular diseas inhibit cathepsin cat shown improv sle lupus nephriti howev effect cat inhibitor sle associ pah sle pah remain unclear anim model translat research sle pah hypothes inhibit cat may affect pah develop arteri remodel associ sle femal anim model sle pah femal mrllpr lupus use evalu role pulmonari arteri remodel sle key find research work establish anim model sle associ pah femal mrllpr mice abl evalu pulmonari arteri remodel start age week week cat protein level identifi marker experiment sle pulmonari hypertens femal mrllpr lupus mice treat administ select cat inhibitor millipor stimul peroxisom prolifer activ receptor gamma ppar lung inhibit cat express pulmonari arteri remodel studi provid anim model femal mrllpr lupus associ pah deeper understand pathogenesi sle pah result may defin role cathepsin prevent progress fatal sle pah provid approach therapeut intervent sle pah
|
D006976;D008180
|
T047;T046
|
36,293,171
|
tissu engin gynecolog femal gynecolog organ dysfunct caus infertil psycholog distress decreas qualiti life affect women incid constant increas due grow rate cancer increas childbear age develop world current treatment often unabl restor organ function occasion caus femal infertil altern treatment option current develop order face inadequaci current practic review patholog current treatment gynecolog organ ovari uterus vagina describ state art tissu engin altern common practic evalu focus vivo model tissu engin ever expand field integr various domain modern scienc creat sophist tissu substitut hope repair replac dysfunct organ use autolog cell applic gynecolog potenti restor femal fertil sexual wellb
|
D006176;D007247
|
T033;T047;T046;T091
|
36,293,170
|
aquaporin gate new twist unravel permeat water channel aquaporin aqp small transmembran tetramer protein facilit water solut gas exchang presenc extens report biolog membran almost live organ although discoveri much recent ion transport system differ biophys approach contribut confirm permeat monom consist close open state introduc term gate mechan field studi aqp nativ membran overexpress heterolog system experiment demonstr water membran permeabl revers modifi respons specif modul regul mechan ph chang evid gate also support high resolut structur water channel differ configur well molecular dynam simul experiment simul approach sustain rearrang conserv residu contribut occlud caviti channel restrict water permeat interest specif charg conserv residu present environ pore thus tetramer structur subject alter posit charg sustain gate thus possibl explor whether displac charg gate current lead conform chang knowledg question yet address review intend analyz suitabl propos first time
|
D020346
|
T123;T116
|
36,293,169
|
genom wide snp marker acceler perenni forest tree breed rate diseas resist marker assist genom wide select ecolog econom import forest tree evid surviv necessari provid raw materi need wood paper industri preserv divers associ anim plant speci protect water soil regul climat forest tree threaten anthropogen factor biotic abiot stress various diseas includ caus fungal pathogen one main threat forest tree lead dieback genom transcriptom studi use next generat sequenc ngs method help reveal architectur resist various diseas exploit natur genet divers select elit genotyp high resist diseas last two decad qtl map studi led identif qtls relat diseas resist trait gene famili transcript factor involv includ nb lrr wrki bzip myb hand due limit recombin event tradit qtl map famili deriv bi parent cross genom wide associ studi gwas base linkag disequilibrium ld unstructur popul overcam limit abl narrow qtls singl gene genotyp mani individu use high throughput marker associ qtl map studi identifi marker close link target trait prerequisit marker assist select mas reduc breed period perenni forest tree genom select gs method use inform marker across whole genom regardless signific develop predict model perform individu relat specif trait gs studi also increas gain per unit time dramat increas speed breed program review articl focus progress achiev field dissect forest tree diseas resist architectur gwas qtl map studi final merit method gs acceler forest tree breed program also discuss
|
D060467;D014197
|
T040;T002
|
36,293,168
|
pgc mef regul transcript carnitin transport octn gene cc cell mous skelet muscl octn slca carnitin transport whose main function activ transport carnitin cell skelet muscl organ regul slca gene transcript shown depend nuclear transcript factor ppar due observ muscl octn mrna level maintain ppar knock mice pgc overexpress cc myoblast increas octn mrna express suspect addit regulatori pathway slca gene transcript inde detect sever bind site myocyt enhanc factor mef upstream region slca gene mefcmefd stimul activ octn promot gene report assay stimul increas pgc blunt slca promot fragment mutat mef bind site demonstr specif bind mef slca gene promot supershift mefdna complex electrophoret mobil shift assay immunoprecipit experi could demonstr interact pgc mef addit sb specif inhibitor p mapk block interferon stimul transcript activ slca gene promot final mice muscl specif overexpress octn show increas octn mrna protein express skelet muscl conclus detect character second stimulatori pathway slca gene transcript skelet muscl involv nuclear transcript factor mef co stimul pgc control p mapk signal cascad
|
D002331;D047492
|
T121;T116;T127;T192;T109
|
36,293,167
|
chronic arsenic exposur upregul express basal transcript factor increas invas non muscl invas papillari bladder cancer line rt bladder target organ inorgan arsenic carcinogen common environment contamin found soil water urotheli carcinoma uc common type bladder cancer bc develop papillari non papillari tumor papillari tumor most non muscl invas nmiuc easier treat better prognosi urotheli carcinoma molecular sub type lumin basal papillari tumor general fall lumin categori basal tumor exclus form muscl invas urotheli carcinoma miuc unclear uc develop aggress basal phenotyp hypothes chronic arsenic exposur papillari lumin bladder cancer would lead develop basal characterist increas invas treat human papillari bladder cancer cell line rt arsenit twenti passag throughout studi key lumin basal geneprotein marker expos cell evalu passag twenti cell inject athym mice evalu tumor histolog measur protein marker use immunohistochemistri data indic chronic treatment alter cellular morpholog decreas sever lumin marker cell cultur histolog tumor generat expos cell similar parent non treat howev appear invas liver display elev level basal marker studi demonstr chronic exposur abl convert non invas papillari bladder cancer invas form acquir basal characterist
|
D002295;D001749;D018053;D001151
|
T121;T104;T196;T191;T131
|
36,293,166
|
perspect rise fall protein turn turn third defin secondari structur helix sheet turn describ year ago account protein residu nonetheless often overlook even misunderstood poor knowledg local protein conform due various factor caus discuss exampl confus still exist assign local protein structur overlap structur potenti absenc stabil hydrogen bond numer type turn softwar difficulti assign visual also propos idea potentiallyparti remedi present turn still help even alphafold era
|
D011506
|
T123;T116
|
36,293,165
|
checkpoint kinas inhibit revers tamoxifen resist er posit breast cancer breast cancer heterogen diseas tamoxifen frequent use treat er posit breast cancer team identifi novel splice variant ncor bq bq mediat tamoxifen resist howev upstream factor modul bq express appar studi reveal tamoxifen treatment caus induct dna damag enhanc bq express show dna damag activ atmchk atrchk signal cascad confirm atmchk signal respons enhanc protein stabil bq sirna small inhibitor target chk result reduct bq express reduc phosphoryl enhanc poli ubiquitin bq inhibit chk cct could revers tamoxifen resist vitro vivo use clinic sampl tissu microarray confirm high p chk express signific associ high nuclear bq express tamoxifen resist poorer overal diseas specif surviv conclus tamoxifen treatment enhanc bq express er posit breast cancer activ atmchk axi target chk promis approach overcom tamoxifen resist er posit breast cancer
|
D013629;D001943
|
T121;T191;T109
|
36,293,164
|
assess brain deriv neurotroph factor bdnf concentr children idiopath nephrot syndrom idiopath nephrot syndrom in chronic diseas affect children earli childhood character proteinuria hypoalbuminemia edema hyperlipidemia date diagnosi usual establish advanc stage proteinuria therefor new method earli in detect desir studi design assess brain deriv neurotroph factor bdnf potenti marker earli diagnosi in studi group includ patient diagnosi idiopath nephrot syndrom n hospit clinic hospit zabrz decemb decemb studi show serum bdnf concentr decreas urin bdnf concentr increas group patient in compar healthi control outcom might relat loss bdnf contribut podocyt structur mainten moreov anticip role bdnf urin protein concentr increas could use direct predictor urin protein fluctuat clinic practic moreov roc curv also shown serum bdnf urin bdnf level might use in marker
|
D009404
|
T047
|
36,293,163
|
flow seq evalu translat driven set natur escherichia coli utr variabl length flow seq method combin fluoresc activ cell sort next generat sequenc deduc larg amount data translat effici singl experi construct librari fluoresc protein base report preced set natur untransl region utr escherichia coli gene usual flow seq librari construct use uniform length sequenc element contrast natur situat function element heterogen length demonstr utr librari variabl length could creat analyz flow seq line previous flow seq experi random utr observ influenc rna secondari structur shine dalgarno sequenc translat effici howev variabl paramet natur utr librari smaller comparison random librari line observ fold differ translat effici best worst bin sort factor result correl obtain ribosom profil
|
D004926;D012270
|
T026;T007
|
36,293,162
|
papaya leaf extract potenti dengu treatment silico studi dengu fever df dengu hemorrhag fever dhf dengu shock syndrom dss caus serious public health problem near million peopl affect death per year tropic subtrop countri despit numer attempt antivir drug vaccin current avail combat manifest challeng discov effici vaccin enhanc surplus presenc effici vector drug resist virus centuri papaya carica papaya extract tradit use treat df dhf dss present studi systemat investig seven compound isol papaya leaf extract regard potenti inhibitor non structur ns protein ns ns play crucial role viral rna replic comput tool appli stretch across classic molecular dock molecular dynam md simul swissadm use calcul bind affin bind free energi absorpt distribut metabol excret adm drug like properti thus identifi kaempferol chlorogen acid quercetin potenti candid kaempferol quercetin score best therefor kaempferol quercetin complex hybrid quantum mechanicalmolecular mechan qmmm geometri frequenc calcul perform follow local mode analysi develop group quantifi kaempferol ns quercetin ns hydrogen bond given non toxic natur wide avail kaempferol quercetin papaya extract almost suscept region result show high ns ns bind affin energi strong hydrogen bond ns ns excel adm properti suggest kaempferol quercetin strong ns ns inhibitor investig vitro
|
D029441;D003716;D003715
|
T168;T005;T002;T047
|
36,293,161
|
meta analysi reveal challeng gap genom phenom research underpin plant drought respons sever drought condit extrem weather event increas worldwid climat chang threaten persist nativ plant communiti ecosystem mani studi investig genom basi plant respons drought howev extent research throughout plant kingdom unclear particular among speci critic sustain natur ecosystem studi aim broaden understand genom phenom gp connect drought stress plant identifi focal taxa futur research bioinformat pipelin develop mine link inform databas abstract public approach identifi gene involv drought respons among plant taxa speci classifi human use gp interact describ within model organ crop speci analysi identifi sever gap gp research literatur databas connect abstract link gene taxonomi data ncbi abstract text mine success identifi potenti gp pathway abstract contain gene taxa phenotyp inform expand gp studi includ non model plant especi adapt drought stress help advanc understand drought respons gp pathway
|
D055864;D017753
|
T070;T082
|
36,293,160
|
challeng long covid manag diseas molecular hallmark propos exercis therapi long coronavirus diseas covid design given novel syndrom develop within month infect sever acut respiratori syndrom coronavirus sar cov present increas incid numer case infect long covid character sequela clinic symptom concern differ organ tissu nervous respiratori gastrointestin renal system skelet muscl cardiovascular apparatus main common molecular caus long covid facet appear relat immun dysregul persist inflammatori status epigenet modif alter neurotrophin releas prevent manag long covid still inappropri mani aspect need clarif exercis known exert deep action molecular dysfunct elicit long covid depend train intens durat continu evid suggest could improv qualiti life long covid patient review explor main clinic featur known molecular mechan under long covid perspect consid exercis co medic long covid manag
|
D000086382
|
T047;T067
|
36,293,159
|
nlrp cutan sccs exampl complex role inflammasom cancer develop protein complex term inflammasom ensur tissu protect pathogen steril stressor induct inflamm mediat differ caspas induc downstream pathway includ activ pro inflammatori cytokin proil induct lytic type cell death regul releas pro inflammatori molecul aberr inflammasom activ under patholog numer auto inflammatori diseas furthermor inflammasom support suppress tumor develop complex cell type stage depend manner human keratinocyt skin nlrp central inflammasom sensor activ cellular perturb induc exampl uvb radiat uvb repres main induc skin cancer common type malign human recent evid demonstr activ nlrp human skin support develop cutan squamous cell carcinoma csccs induc skin inflamm contrast nlrp inflammasom pathway restrain establish csccs suggest stage protein complex tumor suppressor role better understand complex function nlrp develop csccs general inflammasom cancer might pave way novel strategi cancer prevent therapi strategi might includ stage specif modul inflammasom activ downstream pathway mono combin therapi
|
D058847;D012878
|
T123;T191;T116
|
36,293,158
|
ompr like transcript factor negat regul hrprs pseudomona syringa pv actinidia bacteri canker kiwifruit devast diseas caus pseudomona syringa pv actinidia psa type iii secret system tss transloc effector plant cell subvert plant immun promot extracellular bacteri growth requir psa virul despit hrprs hrpl cascad sophist regul express tss effector well document transcript regul hrprs remain determin studi ompr like transcript factor previous identifi dna pull assay found involv regul hrprs gene regulatori mechan function psa explor techniqu includ gene knockout overexpress chip seq rna seq ompr like transcript factor bind site promot region hrprs transcript level hrprs increas delet ompr like decreas upon overexpress ompr like delet background addit ompr like overexpress reduc strain capac form biofilm lipopolysaccharid led slow growth king b medium reduc swim abil although signific effect pathogen kiwifruit host result indic ompr like direct negat regul transcript hrprs may involv regul multipl biolog process psa result provid basi understand transcript regul mechan hrprs psa
|
D044224;D029042
|
T007;T002
|
36,293,157
|
applic mutant librari candida albican function genom candida albican typic opportunist pathogen human caus serious health risk clinic fungal infect construct mutant librari made remark develop studi c albican molecular cellular biolog ongo advanc gene edit includ applic crispr cas novel high effici transposon larg scale genet screen genom wide function analysi acceler investig new genet regulatori mechan associ pathogen resist environment stress c albican import sensit screen base c albican mutant librari critic target identif novel antifung compound lead discoveri secp tfpp gwtp glnp ergp review summar main type c albican mutant librari interpret applic morphogenesi biofilm format fungus host interact antifung drug resist target identif
|
D002176;D000935
|
T121;T004;T195
|
36,293,156
|
asymmetr dimethylarginin marker endotheli dysfunct thrombot antiphospholipid syndrom patient potenti contribut asymmetr dimethylarginin adma high sensit c reactiv protein hscrp endotheli dysfunct ap patient studi detail studi involv ap patient diagnos primari ap pap ap associ system lupus erythematosus sap compar control endotheli dysfunct assess measur flow mediat dilat fmd glyceryl trinitr dilat nmd brachial arteri adma micromol analyz elisa
|
D016736;D013927
|
T047;T046
|
36,293,155
|
rad transloc nucleolus upon uv irradi nucleolar local signal central basic domain nucleolus non membran structur nucleus form around ribosom dna repeat play major role ribosom biogenesi transcript ribosom dna regul mrna translat respons cellular stress includ dna damag rad one protein initi maintain activ atr pathway one major dna damag checkpoint recent report central basic domain rad contain nuclear local signal nuclear transloc rad promot proteasom degrad show central basic domain contain nucleolar local signal well nuclear local signal nucleolar local signal overlap nuclear local signal capabl transport exogen protein nucleolus phosphomimet mutat central basic domain inhibit nucleolar accumul suggest post translat modif site regul nucleolar local nucleolar accumul rad promot proteasom inhibit uv irradi data show nucleolar local rad suggest possibl role rad nucleolus upon uv irradi
|
D019913;D046988
|
T087;T126;T116
|
36,293,154
|
mir pndrg axi control endometri recept nf bzebe cadherin pathway endometri recept essenti success pregnanc impair major caus embryo implant failur microrna mirna regul epigenet modif associ endometri recept howev molecular mechan wherebi mirna regul endometri recept remain unclear therefor investig whether mir potenti target influenc trophoblast cell attach mir express lower level secretori phase prolif phase endometrium tissu fertil donor howev mir express upregul secretori phase infertil women transfect synthet mir p mimic decreas spheroid attach human jar choriocarcinoma cell e cadherin express import endometri recept mir p also downregul n myc downstream regul ndrg studi ndrg upregul secretori phase endometrium tissu induc e cadherin express nuclear factor nf zinc finger e box bind homeobox zeb signal pathway ndrg overexpress deplet cell show alter attach rate jar spheroid collect find indic mir p mediat ndrg downregul impair embryo implant upregul nf zebe cadherin pathway henc mir p potenti biomark negat select endometri recept therapeut target success embryo implant
|
D007247;D035683
|
T123;T033;T114;T047;T046
|
36,293,153
|
lynch syndrom identif saudi cohort endometri cancer patient screen univers approach lynch syndrom ls common caus inherit endometri cancer ec preval molecular characterist ls middl eastern women ec underexplor evalu frequenc ls cohort ec patient saudi arabia total ec case screen util immunohistochemistri ihc mlh promot methyl analysi next generat sequenc technolog total ec classifi dna mismatch repair defici dmmr mlh promot hypermethyl detect ec three ec found ls harbor germlin pathogen variant pvs like pathogen variant lpvs two msh gene one msh gene three ec lynch like syndrom lls carri doubl somat msh pvslpvs seven case found variant uncertain signific cancer relat gene mmr gene result indic ls preval low among saudi ec patient lls common ls ethnic find could help better understand preval mutat spectrum syndrom saudi arabia may help defin best strategi ls identif prevent genet counsel ec patient
|
D003123;D016889
|
T047;T191
|
36,293,152
|
thermofluor base optim strategi stabil recombin human solubl catechol methyltransferas catechol methyltransferas comt involv number medic condit includ catechol estrogen induc cancer great rang cardiovascular neurodegen diseas parkinson diseas current parkinson diseas treatment reli tripl prophylaxi involv dopamin replac levodopa use aromat l amino acid decarboxylas inhibitor use comt inhibitor typic comt high thermolabil solubl isoform scomt lose biolog activ within short time span prevent structur function trial herein character thermal stabil profil lysat cell komagataella pastori contain human recombin scomt hscomt enzym purifi fraction immobil metal affin chromatographi imac upon interact sever buffer addit thermal shift assay tsa biolog activ assess base obtain result potenti condit abl increas thermal stabil hscomt found analysi melt temperatur variat moreov use ionic liquid butyl methylimidazolium chlorid c mim cl along cystein trehalos glycerol ensur complet protein solubil well increment protein tm approxim c thus develop formul enhanc hscomt stabil increment percentag activ recoveri protein store c c respect h format metanephrin time confirm enzym show twice product presenc addit outstand achiev might pave way develop futur hscomt structur biophys studi fundament design novel therapeut molecul
|
D010300;D052578;D002262
|
T120;T116;T103;T126;T047
|
36,293,151
|
character rasraferk signal cascad novel regul factor alpha amanitin induc cytotox huh cell well known hepatotox mechan result alpha amanitin ama exposur aris rna polymeras ii rnap ii inhibit rnap inhibit occur dysregul mrna synthesi howev signal pathway hepatocyt aris ama yet fulli elucid identifi rasraferk signal pathway activ quantit phosphoproteom molecular biolog analys huh cell bioinformat analysi show ama exposur increas protein phosphoryl time depend ama exposur addit phosphoryl increas compon erk signal pathway also uaf spf known splice factor therefor propos novel mechan ama follow rasraferk signal pathway involv aberr splice event activ ama exposur follow aberr splice event lead cell death huh cell
|
D053959;D012319
|
T123;T126;T116
|
36,293,150
|
synthesi lightweight renew microwav absorb bio polyurethanef composit foam structur analysi absorpt mechan sustain renew polym foam use lightweight porous skeleton microwav absorpt novel strategi effect solv problem larg surfac densiti high addit amount narrow absorb band absorb materi articl novel renew microwav absorb foam prepar use sapiums biferum kernel oil base polyurethan foam bpuf porous matrix fe nanoparticl magnet absorb microstructur microwav absorpt perform structur effect properti electromagnet mechan magnet bpuf mbpuf systemat character analyz result show mbpuf display porous hierarch structur multi interfaci provid skeleton match layer fe nanoparticl effect reflect loss rl db frequenc mbpuf ghz ghz wt content fe nanoparticl thick mm surfac densiti mbpuf coat less kgcm thick mm lightweight characterist broadband absorpt attribut porous hierarch structur dielectr combin magnet loss effect indic mbpuf prospect broadband absorb materi field lightweight stealth materi
|
D008872;D011140
|
T122;T070;T109;T057
|
36,293,149
|
chi circ posit regul differenti goat intramuscular adipocyt via novel mir cd axi goat import livestock goat meat essenti local peopl intramuscular fat imf content great influenc qualiti goat meat intramuscular preadipocyt differenti close relat imf deposit howev potenti regulatori mechan remain unclear circrna reveal involv multipl biolog progress studi took primari goat intramuscular preadipocyt gimpa studi model verifi function mechan chi circ abund regul matur adipocyt gima result show express level chi circ gradual increas earli stage gimpa differenti chi circ confirm promot gimpa lipid droplet aggreg regul adipogen differenti determin promot gimpa differenti mechanist chi circ exert function spong novel mir therebi regul express cd result studi provid novel signific inform better understand molecular regulatori mechan intramuscular preadipocyt differenti therebi provid new refer intramuscular fat adipogenesi goat
|
D006041;D035683
|
T123;T015;T114
|
36,293,148
|
neutrophil gelatinas associ lipocalin potenti predict biomark melanoma non melanoma skin cancer psoriat patient pilot studi studi demonstr higher risk nonmelanoma skin cancer nmsc modest increas melanoma risk patient psoriasi date biomark predict evolut identifi yet
|
D012878;D011565
|
T047;T191
|
36,293,147
|
effect obes high densiti lipoprotein concentr patholog characterist alzheim diseas high fat diet fed mice typic patholog featur alzheim diseas ad accumul amyloid plaqu brain reactiv glial cell astrocyt microglia clinic develop ad obes known correl studi analyz chang ad patholog characterist xfad mice obes induct high fat diet hfd surpris high densiti lipoprotein apolipoprotein ai apoa serum level increas without low densiti lipoprotein alter hfd group reactiv astrocyt microglia dentat gyrus hippocampus fornix hypothalamus xfad mice decreas transgen tg hfd high group final accumul amyloid plaqu dentat gyrus region hippocampus also signific decreas tg hfd high group result suggest increas high densiti lipoprotein level especi increas apoa serum level allevi patholog featur ad could new potenti therapeut strategi ad treatment
|
D000544
|
T047;T048
|
36,293,146
|
aphelenchoid besseyi ab far interact arabidopsi thaliana atadf interfer actin cytoskeleton promot nematod parasit pathogen fatti acid retinol bind protein far uniqu protein found nematod consid potenti target control parasit howev function nematod parasit pathogen interact host still unclear studi investig specif role rice white tip nematod rwtns aphelenchoid besseyi protein ab far elucid parasit pathogen process nematod result show express level ab far signific regul besseyi infect plant immunofluoresc subcellular localis show ab far secret plant tissu main bodi wall nematod might act nucleus cytoplasm plant cell pathogen rwtns enhanc arabidopsi thaliana overexpress ab far inhibit ab far rnai thaliana yeast two hybrid co ip bifc nematod inocul experi show ab far could interact thaliana actin depolymer factor protein atadf thaliana adf mutant suscept nematod vitro actin filament depolymeris assay demonstr ab far could inhibit atadf mediat depolymeris actin filament turnov process cellular actin filament also affect thaliana overexpress ab far addit flg mediat host defenc respons suppress thaliana overexpress ab far adf mutant therefor studi confirm rwtns affect turnov actin filament remodel mediat atadf ab far secret thus inhibit plant pamp trigger immun pti promot parasit pathogen nematod
|
D017360;D017187;D017168;D014431
|
T204;T002
|
36,293,145
|
alter express aqp aqp brain barrier cerebrospin fluid may affect cerebr water balanc chronic hypertens hypertens lead caus cardiovascular affect prematur death worldwid spontan hypertens rat shr common anim model hypertens character secondari ventricular dilat hydrocephalus aquaporin aqp main water channel respons brain water balanc present studi focus defin express aqp time cours develop spontan chronic hypertens perform immunofluoresc elisa examin brain aqp shr wistar kyoto wki rat studi month old signific decreas aqp choroid plexus shr month group compar age match control p lt ependyma aqp signific decreas shr month group compar control shr month group p lt per contra aqp increas astrocyt end feet month month shr rat p lt csf aqp detect higher shr month group age match control group csf find confirm western blot shr ependym choroid aqp decreas time csf aqp level increas turn astrocyt aqp increas shr rat aqp alter may underli hypertens depend ventriculomegali
|
D006849;D006973;D020346
|
T123;T116;T033;T019;T047
|
36,293,144
|
review highlight link epigenet covid infect vitamin high transmitt infecti covid remain major threat worldwid elder comorbid individu vulner vaccin current avail therapeut drug help eas viral outbreak prevent serious health outcom epigenet modif regul gene express chang chromatin structur link viral pathophysiolog sinc epigenet modif contribut life cycl virus host immun respons infect epigenet drug promis treatment target amelior covid defici multifunct secosteroid hormon vitamin global health threat vitamin receptor function regul gene involv immun apoptosi prolifer differenti inflamm amass evid also indic biolog relat vitamin reduc diseas risk receptor modul epigenet mechan immunomodulatori effect vitamin suggest role vitamin covid therapeut agent therefor review highlight epigenet effect covid vitamin also propos role vitamin covid infect
|
D000086382;D014808
|
T047;T067
|
36,293,143
|
genet epigenet x chromosom sexual differenti brain mani decad date neuroendocrinologist delv key contribut gonad hormon generat sex differ develop brain express sex specif physiolog behavior phenotyp adulthood howev recent year role sex chromosom matter start serious explor unveil beyond gonad determin know diverg evolutionari process suffer x chromosom determin encod most dissimilar genet inform subject differ epigenet regul characterist togeth contribut generat sex differ xx xy cellsindividu zygot throughout life review discuss relev data show particular x link gene epigenet mechan control express inherit involv along independ gonad hormon generat sex differ brain
|
D012733;D014998
|
T026;T040
|
36,293,142
|
magneto fluoresc mesopor nanocarri dual deliveri ofloxacin doxorubicin tackl opportunist bacteri infect colorect cancer cancer relat opportunist bacteri infect one major barrier success clinic therapi often correl product genotox factor higher cancer incid although dual anticanc antimicrobi therapi grow therapeut fashion still fall short come specif deliveri local action vivo system nanoparticl seen potenti therapeut vector mean intrins antibacteri properti effect deliveri capac mean repeat report modul maneuver herein report product biocompat antimicrobi magneto fluoresc nanosystem nano deliveri dual doxorubicin ofloxacin formul cancer relat bacteri infect drug deliveri capac render mesopor silica matrix confirm high load capac stimuli driven releas drug prefer tumor like acid media ph depend emiss surfac fluoresc siqd provid insight nano surfac behavior pore avail siqd work pore gate hyperthermia induc heat generat febril temperatur doubl drug releas nano load system demonstr signific antimicrobi activ specif applic hyperthermia condit nano structur antimicrobi properti confirm potenti use futur dual anticanc antimicrobi therapeut vector due drug load capac surfac avail modif bioactiv target speci
|
D006979;D053758;D000890;D015179
|
T061;T121;T191;T073
|
36,293,141
|
individu combin effect bisphenol bisphenol af prostat cell prolifer nf b signal pathway ubiquit environment endocrin disruptor bisphenol bpa induc prostat dysfunct howev date studi focus littl perturb prostat health initi bpa deriv bisphenol af bpaf co exposur bisphenol compound vivo studi oral administr male rat bpa gkg bpaf gkg inhibitor nuclear transcript factor b nf b pyrrolidinedithiocarbam pdtc mgkg base anatom analysi patholog observ pcna express consid low dose bpa bpaf facilit ventral prostat hyperplasia rat result ihc elisa mirror regul nf b p cox tnf egfr bpa bpaf induc prostat toxic vitro studi found addit effect combin exposur bpa nm bpaf nm could caus elev prolifer reduct apoptosi level human prostat stromal cell wpmi fibroblast hprf meanwhil under biomark nf b signal pathway also involv abnorm prolif progress prostat cell find recapitul induct bpaf exposur co treatment bpa bpaf prostat hyperplasia emphas modul nf b signal pathway
|
D052244;D011470
|
T131;T039;T191;T047
|
36,293,140
|
toward improv ornament attribut chrysanthemum recent progress biotechnolog advanc incess develop introduct novel cultivar improv floral attribut vital dynam ornament industri chrysanthemum chrysanthemum morifolium high favor ornament plant rank second global cut flower trade rose develop new chrysanthemum cultivar improv innov modif ornament attribut includ floral color shape plant architectur flower time enhanc shelf life biotic abiot stress toler major goal chrysanthemum breed despit econom import ornament plant applic convent molecular breed approach various key trait chrysanthemum hinder owe genom complex heterozygos limit gene pool avail although classic breed chrysanthemum result develop sever hundr cultivar various morpholog variat genet transcript control various import ornament trait remain unclear covet blue color flower chrysanthemum achiev convent breed mutat breed due technic limit howev blue hu flower develop genet engin transgen molecular breed success employ lead substanti progress improv various trait recent avail whole genom sequenc chrysanthemum offer platform extens employ mas identifi larg number marker qtl map gwas dissect genet control complex trait combin ngs multi omic platform genom edit technolog provid tremend scope deciph molecular regulatori mechan howev applic integr technolog remain inadequ chrysanthemum review therefor detail signific floral attribut describ effort recent advanc highlight possibl futur applic toward improv crucial ornament trait global popular chrysanthemum plant
|
D031202
|
T002
|
36,293,139
|
dysregul placent lipid hydrolysi high fathigh cholesterol feed gestat diabet mellitus mice advanc matern age obes main risk factor develop gestat diabet mellitus gdm obes consequ increas storag triacylglycerol tg cytosol lysosom lipid hydrolas break tg cholesteryl ester ce releas fatti acid fa free cholesterol glycerol recent shown intracellular lipas present activ mous placenta defici lysosom acid lipas alter placent fetal lipid homeostasi date intracellular lipid hydrolysi gdm poor studi despit import role fa condit therefor hypothes intracellular lipas dysregul pregnanc complic matern high fathigh cholesterol hfhcd feed without gdm placenta hfhcd fed mice without gdm effici indic increas nutrient transfer fetus increas activ placent ce tg hydrolas placenta dam fed hfhcd without gdm result upregul cholesterol export fetus placent tg accumul result indic hfhcd induc dysregul placent lipid hydrolysi contribut fetal hepat lipid accumul possibl fetal overgrowth least mice
|
D016640
|
T047
|
36,293,138
|
gdf regul pc neural stem cell via alk depend pik akt signal pathway growth differenti factor gdf belong transform factor superfamili regul anterior posterior pattern inhibit neurogenesi embryon develop howev recent studi recogn gdf rejuven anti age factor revers age relat cardiac hypertrophi repair injur skelet muscl promot cognit function etc effect gdf contradictori mechan action still well clarifi object present studi investig effect gdf pc neural stem cell vitro reveal under mechan systemat assess effect gdf life activ pc cell gdf signific suppress cell prolifer migrat promot differenti apoptosi arrest cell cycl gm phase tmt base proteom analysi phospho antibodi microarray reveal pik akt pathway enrich treat gdf inhibit alk pik obvious attenu effect gdf pc neural stem cell exert gdf regul neural stem cell alk depend pik akt signal pathway summari result demonstr gdf could negat regul neurogenesi via alk activ pik akt pathway direct act neural stem cell
|
D051057;D058953
|
T126;T116;T025
|
36,293,137
|
comprehens silico function predict analysi cdkl singl amino acid substitut catalyt domain cyclin depend kinas like cdkl serinethreonin protein kinas whose patholog mutat caus cdkl defici disord missens mutat concentr catalyt domain therefor anticip whether mutat region affect cdkl function inform clinic diagnosi studi comprehens predict pathogen missens substitut catalyt domain cdkl use silico analysi evalu accuraci missens substitut evalu pathogen benign silico tool polyphen humdiv modehumvar mode provean sift select individu combin one anoth determin perform use previous report mutat refer substitut predict pathogen accur use three tool best perform score accuraci sensit specif matthew correl coeffici mcc achiev combin polyphen humdiv polyphen humvar provean provid comprehens inform could accur predict pathogen diseas might use aid clinic diagnosi
|
D020125;D018844
|
T045;T126;T116
|
36,293,136
|
toler oral supplement microencapsul ferric sacchar compar ferrous sulphat healthi premenopaus woman crossov random doubl blind clinic trial singl center crossov random doubl blind control clinic studi conduct assess toler profil especi regard gastrointestin complaint oral supplement ab forti microencapsul ferric sacchar mfs compar convent ferrous sulphat fs healthi premenopaus women dose mgday element iron use test product administ consecut day washout period two menstrual episod minimum one month two intervent period subject complet simpl answer questionnair daili day intervent washout period captur symptom associ oral iron supplement overal health aspect follow product consumpt incid symptom number complaintssymptom overal intens total day symptom found signific higher fs consumpt compar mfs better toler profil mfs fs substanti product compar real life set ie washout period overal administr studi product safe serious signific advers event report summari current studi show better toler mfs prepar compar fs present mfs well toler safe option improv iron nutrit
|
D005296;D018798
|
T104;T047
|
36,293,135
|
epigenet regul polycomb complex drosophila human relat communic diseas pathogenesi although cell human bodi made dna cell undergo differenti behav differ develop integr extern intern stimuli via specif mechan epigenet one mechan compris dnarna histon modif non code rnas regul transcript without chang genet code discoveri first polycomb mutant phenotyp drosophila start studi epigenet year ago sinc consider number polycomb group pcg gene drosophila discov preserv mammal includ human pcg protein exert influenc gene repress act complex modifi histon compact chromatin within nucleus articl discuss knowledg pcg repress mechan drosophila translat human communic diseas research
|
D029721;D003141
|
T123;T047;T116
|
36,293,134
|
identif extracellular nucleas influenc soak rna interfer effici bursaphelenchus xylophilus rna interfer rnai effici dramat vari among differ nematod impact research gene function pest control bursaphelenchus xylophilus pine wood nematod rnai mediat gene silenc unstabl interfer effici soak dsrna solut factor remain unknown use agaros gel electrophoresi found dsrna degrad nematod secret soak system respons low rnai effici base previous publish genom secretom data b xylophilus nucleas screen includ extracellular nucleas potenti factor reduc rnai efficaci confirm function nucleas rnai effici eight extracellular nucleas gene bxynuc clone genom bxynuc bxynuc bxynuc upregul respons ds gfp consid major nucleas perform dsrna degrad soak dsrna nucleas bxynuc bxynuc bxynuc pat gene ineffect rnai simultan h express pat gene decreas respect soak h express pat gene decreas ds bxynuc ds pat ds bxynuc ds pat group respect howev without ds p ds bxynuc alon could caus downregul pat gene express ds bxynuc could disturb gene conclus nucleas bxynuc might major barrier rnai effici b xylophilus
|
D017187;D028223;D017168
|
T002;T204
|
36,293,133
|
omic data data represent deep learn base predict model medic discoveri main depend capabl process analyz biolog dataset inund scientif communiti still expand cost next generat sequenc technolog decreas deep learn dl viabl method exploit massiv data stream sinc advanc quick success innov howev obstacl scientif progress emerg difficulti appli dl biolog field evolv breakneck pace thus make hard individu occupi front line paper aim bridg gap help comput scientist bring valuabl expertis life scienc work provid overview common type biolog data data represent use train dl model addit inform model various task tackl essenti inform dl expert background biolog need order particip dl base research project biomedicin biotechnolog drug discoveri altern studi could also use research biolog understand util power dl gain better insight extract import inform omic data
|
D000077321
|
T066
|
36,293,132
|
effect sex obes lep variant leptin level associ intervertebr disc degener intervertebr disc degener ivdd obes genet known risk factor chronic process alter structur function intervertebr disc ivd circul leptin posit correl bodi weight often measur elucid pathogenesi ivd degener studi examin associ lep singl nucleotid polymorph snps genet environment effect ivdd total taiwanes patient ivdd mean age year undergo cervic discectomi neck pain lumbar discectomi back pain enrol commerci avail enzym link immunosorb assay elisa kit measur circul plasma leptin level taqman snp genotyp assay genotyp lep snps rs rs leptin level signific increas obes individu p lt non obes obes women p lt domin model recod minor allel rs rs associ higher leptin level individu p p associ lep snps leptin level signific obes women p p respect interact effect sex obes particular among obes women interact p respect find demonstr snps sex specif associ bmi ivdd patient obes sex particular among obes women may modifi lep transcript effect
|
D020738;D055959
|
T125;T047;T116;T190
|
36,293,131
|
chitosan versus carboxymethyl chitosan cryogel bacteri colon human embryon kidney cell cultur co cultur potenti chitosan carboxymethyl chitosan cmc cryogel cross link diglycidyl ether butandiol bddge poli ethylen glycol pegdg compar term cultur hek cell line prevent bacteri colon scaffold first attempt appli cryogel co cultur bacteria human cell undertaken toward develop new model host pathogen interact bioimplant associ infect use combin scan electron microscopi confoc laser scan microscopi flow cytometri demonstr cmc cryogel provid microenviron stimul cell cell interact growth tight pack multicellular spheroid cell substrat interact domin chitosan cryogel despit signific differ swell capac young modulus bddge pegdg cross link scaffold chitosan cryogel demonstr mild antimicrobi properti pseudomona fluoresc could prevent format staphylococcus aureus biofilm dmem media cmc cryogel effici prevent adhes colon p fluoresc aureus surfac demonstr antifoul properti rather abil kill bacteria applic cmc cryogel co cultur hek spheroid p fluoresc reveal higher resist human cell bacteri toxin co cultur
|
D059985;D048271
|
T121;T130;T109
|
36,293,130
|
virtual drug reposit tool identifi natur small molecul synerg lumacaftor fdel cftr bind rescu cystic fibrosi hereditari diseas main caus delet phe fdel cystic fibrosi transmembran conduct regul cftr protein thus withheld endoplasm reticulum rapid degrad ubiquitinproteasom system cystic fibrosi remain potenti fatal diseas becom treatabl chronic condit due cftr rescu drug use combin increas therapeut effect due synerg action also dietari supplement natur compound combin approv drug could repres promis strategi allevi cystic fibrosi symptom base screen silico drug reposit small synthet natur compound aifa databas evalu capac interact high druggabl lumacaftor bind site fdel cftr among identifi hit nicotinamid nam predict accommod lumacaftor bind region fdel cftr without compet drug rather stabil bind effect capac nam bind fdel cftr lumacaftor uncompetit manner valid experiment surfac plasmon reson analysi final capac nam synerg lumacaftor increas cftr rescu activ demonstr cell base assay studi suggest possibl identif natur small molecul devoid side effect endow capac synerg drug current employ treatment cystic fibrosi hope increas therapeut efficaci lower dose
|
D019005;D003550
|
T123;T047;T116
|
36,293,129
|
protect effect panthenol rhabdomyolysi induc acut kidney injuri investig nephroprotect effect panthenol rhabdomyolysi induc acut kidney injuri aki adult male wistar rat inject glycerol solut induc rhabdomyolysi anim rhabdomyolysi inject panthenol mgkg day day examin aki marker renal histolog antioxid capac protein glutathionyl kidney uncov mechan panthenol effect rhabdomyolysi kidney shown pathomorpholog alter mononuclear infiltr dilat tubul hyalin cast henl loop collect duct activ skelet muscl damag marker creatin kinas lactat dehydrogenas increas myoglobinuria observ creatinin bun pantetheinas activ serum urin rose sign oxid stress kidney tissu rhabdomyolysi rat increas level lipid peroxid product activ antioxid enzym sod catalas glutathion peroxidas allevi administr panthenol applic improv kidney morpholog decreas aki marker mechan panthenol benefici effect associ increas total coenzym level activ kreb cycl enzym attenu protein glutathionyl panthenol protect kidney rhabdomyolysi induc aki antioxid effect normal mitochondri metabol modul glutathion depend signal
|
D012206;D058186
|
T047;T046;T037
|
36,293,128
|
transcript factor import regul chang behavior domest gray rat quantit data rna sequenc studi hereditari fixat tame behavior phenotyp anim domest remain relev import basic research appli signific model anim gray rat rattus norvegicus bred either enhanc reduct defens respons human first time use high throughput rna sequenc investig differenti express gene tissu sampl tegment region midbrain month old rat show either tame aggress behavior total differenti express gene deg adjust p valu lt fold chang gt identifi upregul downregul gene tissu sampl tame rat compar aggress rat among three gene encod transcript factor tfs detect ascl upregul wherea fos fosb downregul tissu sampl brain tame rat brain deg annot associ extracellular matrix compon transport protein neurotransmitt system signal molecul immun system protein believ deg encod protein constitut multifactori system determin behavior rat artifici select demonstr sever structur subtyp e box motif known bind site mani development tfs bhlh class includ ascl subfamili tfs enrich set promot deg downregul tissu sampl tame rat ascl may act repressor target gene development tfs bhlh class hypothes express tf gene ascl tame rat indic longer neurogenesi compar aggress rat sign neoteni domest thus domest model show new function tf ascl may play import role behavior chang anim
|
D000071278;D001522
|
T078;T053
|
36,293,127
|
non code rnas implicit chronic myeloid leukemia therapi resist chronic myeloid leukemia cml myeloprolif neoplasm initi presenc fusion gene bcr abl develop tyrosin kinas inhibitor tkis high specif p bcr abl constitut activ tyrosin kinas encod bcr abl great improv prognosi cml patient surviv rate cml near parallel age match control howev therapi resist remain persist problem pursuit cure tki resist attribut bcr abl depend independ mechan recent role non code rnas ncrnas increas explor due frequent dysregul varieti malign specif microrna mirna circular rnas circrna long non code rnas lncrnas shown contribut develop progress therapi resist cml sinc ncrna exhibit multipl function capabl control gene express exert effect cml resist divers set mechan pathway case ncrnas tumor suppress function silenc cml oncogen properti overexpress discuss relev mani aberr express ncrnas effect therapi resist cml
|
D062085;D015464;D035683
|
T123;T191;T114
|
36,293,126
|
lysyl oxidas famili protein prospect therapeut target cancer lysyl oxidas lox famili consist lox lox like protein loxl respons coval crosslink collagen elastin thus maintain stabil extracellular matrix ecm function maintain connect tissu function embryon develop wound heal recent studi found aberr express activ lox famili occur various type cancer prove lox famili main perform tumor microenviron tme remodel function extens involv tumor invas metastasi immunomodul prolifer apoptosi etc relev translat research progress lox famili expect effect target tumor therapi review research progress lox famili tumor progress therapi provid novel insight futur explor relev tumor mechan new therapeut target
|
D008249;D009369
|
T191;T126;T116
|
36,293,125
|
optogenet fmri brain wide circuit analysi sensori process sensori process complex neurolog process receiv integr respond inform one bodi environ close relat surviv well neurolog disord brain wide network sensori process difficult investig due dynam regul multipl brain circuit optogenet neuromodul techniqu use light sensit protein combin function magnet reson imag ofmri measur whole brain activ sinc ofmri increas use investig brain circuit under sensori process decad systemat review recent ofmri studi sensori circuit discuss challeng optogenet fmri rodent
|
D062308;D008279
|
T063;T060;T170;T059
|
36,293,124
|
neutral abil singl domain vnar antibodi vitro neutral sar cov variant concern sever acut respiratori syndrom coronavirus causal pathogen coronavirus diseas covid emerg new variant differ mutat pattern limit therapeut option avail complic develop effect neutral antibodi target spike protein variabl new antigen receptor vnar constitut neutral antibodi technolog introduc list possibl therapeut option sar cov uniqu qualiti vnar high affin target molecul capac paratop reformat relat high stabil make attract molecul counteract emerg sar cov variant studi character vnar antibodi sp isol synthet phage librari vnar domain phage display plasma high antibodi titer sar cov use select displac vnar antibodi bound antigen sar cov receptor bind domain rbd silico data suggest sp bind epitop locat within ace bind interfac neutral abil sp test live delta omicron sar cov variant found clear infect variant lung cell line ace tmprss studi highlight potenti vnar act neutral antibodi emerg sar cov variant
|
D061905;D000086382
|
T129;T047;T116;T067
|
36,293,123
|
chalcon acridin hybrid suppress melanoma cell progress via gm cell cycl arrest dna damag apoptosi modul map kinas activ studi focus investig antiprolif effect chalcon hybrid melanoma cancer cell among seven chalcon hybrid chalcon acridin hybrid c potent select antiprolif mechan studi vitro studi reveal potent antiprolif effect c via cell cycl arrest apoptosi induct cell cycl arrest gm phase associ modul express phosphoryl specif cell cycl associ protein cyclin b p chk tubulin well activ dna damag respons pathway chalcon c also induc apoptosi accompani mitochondri dysfunct evidenc decreas mitochondri membran potenti increas baxbcl xl ratio cytochrom c releas follow caspas activ addit increas phosphoryl map kinas erk p jnk observ chalcon c treat melanoma cell strong antiprolif activ chalcon acridin hybrid suggest may use antimelanoma agent human
|
D002599;D047188;D008545
|
T121;T191;T109
|
36,293,122
|
ppgpp general stress respons alarmon requir express hemolysin toxin uropathogen escherichia coli isol j ppgpp intracellular sensor respons differ type stress coordin rearrang gene express pattern bacteria promot adapt surviv new environment condit first describ modul metabol adapt respons ppgpp modul express gene belong divers function categori escherichia coli ppgpp regul express cellular factor import urinari tract infect character role alarmon regul hlycabdii operon upec isol j encod toxin hemolysin induc cytotox infect bladder epitheli cell ppgpp requir express hemolysin encod hlycabdii stimul transcript express prototrophi suppressor mutat ppgpp defici strain restor hemolysin express operon wild type level confirm requir ppgpp express ppgpp stimul hlycabdii express independ rpos rfah zur h ns express hlycabdii promot c low osmolar ppgpp requir thermoregul osmoregul hlycabdii operon studi commens upec isol demonstr upec specif factor strict requir ppgpp mediat regul describ data support role ppgpp particip coordin regul express bacteri factor requir infect
|
D056689;D004927;D029968
|
T047;T007;T116
|
36,293,121
|
molecular mechan takotsubo syndrom takotsubo syndrom tts sever revers acut heart failur syndrom occur follow high catecholaminerg stress tts patient similar acut coronari syndrom chest pain dyspnoea st segment chang electrocardiogram characteris apic akinesia left ventricl basal hyperkinesia absenc culprit coronari arteri stenosi pathophysiolog tts complet understood pauciti evid guid treatment mechan tts thought involv catecholaminerg myocardi stun microvascular dysfunct increas inflamm chang cardiomyocyt metabol summaris avail literatur focus molecular basi pathophysiolog tts advanc understand condit
|
D054549;D054058
|
T047
|
36,293,120
|
proteom unveil post mortem chang beef muscl protein provid insight variat meat qualiti trait crossbr young steer heifer rais feedlot proteom wide use studi muscl biolog meat qualiti trait differ speci includ beef beef proteom studi allow better understand biolog process relat meat qualiti trait determin studi aim deciph mean two dimension electrophoresi page mass spectrometri bioinformat chang post mortem muscl focus protein differenti express longissimus thoraci lt muscl immunocastr young heifer steer carcass trait chemic composit ph instrument color l b cook loss warner bratzler shear forc wbsf meat f montana nellor cattl also evalu backfat thick bft intramuscular fat content imf higher heifer p lt respect evapor loss el lower compar steer differ p gt observ tender evalu wbsf day post mortem ph color trait l b experiment group studi reveal sever protein differenti express protein heifer compar steer p lt heifer protein involv nutrient transport tf alb mb energi metabol aldoa gapdh pkm oxid stress respons stress hspa ca associ greater bft imf deposit higher express protein indic greater oxid capac lower glycolyt activ lt muscl heifer steer greater abund protein express relat muscl contract protein structur acta tpm tnnt energi metabol eno eno pygm pgm tpi atp metabol atpfb pebp ak indic greater glycogenolysi lt muscl suggest shift glycolyticoxid fiber steer
|
D009124;D040901
|
T123;T091;T116
|
36,293,119
|
understand ocular find manifest system lupus erythematosus updat review literatur system lupus erythematosus sle chronic multisystem autoimmun diseas one third patient suffer sle various ocular manifest ocular find may repres initi manifest system diseas may lead sever ocular complic even loss vision ocular manifest often associ degre system inflamm also preced occurr system symptom earli diagnosi adequ manag patient sle crucial requir cooper various specialist proper prepar ophthalmologist help differenti complic sle ocular disord new therapi sle promis potenti benefit howev ocular side effect still unknown
|
D008180;D005128
|
T047
|
36,293,118
|
radiat tool neurodegener potenti treatment amyloidosi central nervous system radiotherapi rt relat safe establish treatment cancer goal kill tumor cell lowest toxic healthi tissu use disord involv cell loss counterintuit howev ioniz radiat hormet natur deleteri benefici effect depend appli current evid indic radiat could promis treatment neurodegen disord involv protein misfold amyloidogenesi alzheim parkinson diseas low dose rt trigger antioxid anti inflammatori tissu regener respons rt use treat peripher amyloidosi similar neurodegen disord molecular perspect ioniz radiat prevent amyloid format hallmark cell cultur anim model pilot clinic trial although hypothes formul mechan action rt system amyloid deposit still unclear uncertainti remain regard impact central nervous system howev new rt modal low dose rt flash proton therapi nanoparticl enhanc rt could increas biolog effect reduc toxic current evid indic potenti rt treat neurodegener explor
|
D000686;D019636
|
T047
|
36,293,117
|
inflamm caus exacerb covid skin inflamm covid recent emerg viral infect worldwid sar cov causat virus believ emerg bat coronavirus probabl host convers bat coronavirus highest gene homolog sar cov specif infect deep forest bat china whose habitat extend middl east southern europ host convers might occur due deforest human expos wild bat environ never encount sar cov infect cell two mechan receptor ace help enzym tmprss membran fusion help elastas inflammatori condit obes hypertens diabet mellitus pulmonari diseas caus poor prognosi covid age anoth factor promot poor prognosi diseas age caus low level persist inflamm human promot poor prognosi covid psoriasi atop dermat major inflammatori skin diseas inflammatori skin condit howev seem caus poor prognosi covid base epidemiolog data accumul far mechan need elucid
|
D000086382;D002685
|
T047;T015;T067
|
36,293,116
|
radiovaccin strategi cancer treatment integr photodynam therapi generat vaccin radiotherapi therapeut cancer vaccin becom firm establish reliabl profici form tumor immunotherapi repres promis approach substanti advanc success treatment malign diseas one attract vaccin strategi use vaccin materi whole tumor cell treat ex vivo rapid tumor ablat therapi instig stress signal respons culmin immunogen cell death icd one treatment photodynam therapi pdt under mechan critic element respons potenc vaccin discuss review radiotherapi emerg suitabl compon combin therapi protocol vaccin argument prospect optim tumor control use radiovaccin strategi involv x ray irradi plus pdt vaccin present togeth find support valid
|
D019496;D010778;D009369
|
T061;T129;T121;T116;T191
|
36,293,115
|
effici agrobacterium rhizogen mediat hairi root transform method soybean root biolog studi stabl genet transform soybean time consum ineffici simpl practic altern method hairi root transform mediat agrobacterium rhizogen wide appli studi root specif process nodul biochem molecular function gene interest gene edit effici crisprca biolog reactor produc therefor mani laboratori develop uniqu protocol obtain hairi root composit plant compos transgen root wild type shoot howev protocol still suffer shortcom low effici time space cost consumpt address issu develop new protocol effici regener transform hairi root er soybean integr optim main current method achiev high effici hairi root regener transform within shorter period use less space er method obtain regener hairi root explant averag transform frequenc promot simultan compar analysi function sever gene er experiment verifi promot gus report protein subcellular local crisprca gene edit experi employ approach identifi sever novel potenti regul nodul nucleoporin nup sub complex show develop depend tissu depend express pattern indic import role nodul soybean thus new er method effici econom approach investig root nodul biolog also gene function
|
D013025;D028861
|
T168;T116;T123
|
36,293,114
|
nac maintain root meristem activ repress transcript efa arabidopsi root meristem reserv undifferenti cell guid root develop maintain root meristem ident therefor continu root growth rate cell differenti must coordin rate generat new cell e promot bind factor efa shown regul root growth control gs cell cycl transit arabidopsi thaliana found nac member namatafcuc famili transcript factor regul root growth direct repress transcript efa loss nac trigger regul efa express caus reduc meristem size short root phenotyp larg rescu mutat efa analysi show nac shown regul root meristem control endopolyploidi level efa depend manner studi provid evid show nac maintain root meristem size root growth direct repress transcript efa arabidopsi
|
D017360;D029681
|
T116;T002
|
36,293,113
|
klk regul mmp mmp via bradykinin receptor biomark differenti latent activ bovin tuberculosi establish kallikrein klk express close relat bovin tuberculosi btb develop herein sought clarifi regulatori mechan klk applic tuberculosi diagnosi klk knockdown macrophag produc sirna transfect bradykinin receptor br includ br br block specif inhibitor mannos cap lipoarabinomannan manlam extract mycobacterium bovi bovi use studi mechan klk activ addit construct differ mous model repres latent activ stage bovi infect mous model clinic serum sampl use assess diagnost valu biomark method confirm klk regul mmp mmp via br klk upregul mediat bovi specif antigen manlam klk mmp mmp harbor signific valu serolog marker differenti latent activ btb especi klk conclus identifi novel signal pathway klkbrerkmmp bovi infect macrophag activ manlam signal pathway klk use serolog marker differenti latent activ btb import klk also enorm potenti clinic diagnosi human tuberculosi tb
|
D014380;D009169;D014376;D009163
|
T047;T007
|
36,293,112
|
microbi precipit pb ii wild strain paraclostridium bifermentan klebsiella pneumonia isol industri obtain microbi consortium studi focus determin microbi precipit abil bacteri strain isol industri obtain pb ii resist microbi consortium previous research demonstr effect consortium bioprecipit adsorpt pb ii solut bioremedi pb ii use microbi precipit provid altern option pb ii remov wastewat strain klebsiella pneumonia paraclostridium bifermentan success isol consortium obtain batteri recycl plant south africa experi conduct h provid insight short long term precipit abil bacteria various initi concentr pb ii investig found p bifermentan abl remov pb ii solut initi pb ii concentr mg l k pneumonia abl remov pb ii initi pb ii concentr approxim initi pb ii concentr p bifermentan abl remov pb ii solut k pneumonia abl remov pb ii solut h ident precipit obtain strain vari pbs pb main speci precipit p bifermentan pbo either pbcl pb po precipit k pneumonia various factor investig experi metabol activ nitrat concentr residu pb ii concentr extracellular intracellular pb ii concentr precipit ident factor provid greater understand mechan utilis bacteria bioprecipit adsorpt pb ii result use step toward appli process industri scale
|
D007711;D062065
|
T083;T007;T069
|
36,293,111
|
ojeoksan amelior cisplatin induc acut kidney injuri mice downregul mapk nf b pathway acut kidney injuri aki major side effect cisplatin crucial anticanc agent therefor necessari develop drug protect cisplatin induc nephrotox ojeoksan oj tradit blend herbal prescript most use korea howev report efficaci oj cisplatin induc aki investig reno protect effect oj aki oral administ mgkg oj mice h intraperiton inject mgkg cisplatin oj inhibit increas blood urea nitrogen bun serum creatinin scr level reduc histolog chang kidney like loss brush border renal tubular necrosi cast format administr osj reduc level pro inflammatori cytokin interleukin il il tumor necrosi factor tnf addit oj inhibit mitogen activ protein kinas mapk nuclear factor kappa b nf b pathway cisplatin induc aki result suggest oj attenu cisplatin induc aki downregul mapk nf b pathway
|
D058186;D000970
|
T121;T047;T037;T109
|
36,293,110
|
associ circul microrna mir p mir p mir b p mir p mir p chronic allograft dysfunct renal transplant recipi chronic allograft dysfunct cad major condit affect long term kidney graft surviv serum microrna mirna report biomark various condit allograft injuri upregul mir best known mirna chang graft tissu urin plasma howev correl plasma mir sever cad remain unclear studi kidney transplant recipi late graft surviv year enrol cad group n either egfr mlmin biopsi prove chronic allograft nephropathi reject control group n egfr mlmin without proteinuria hematuria consecut month studi perform rna sequenc profil mirna express six differenti express mirna cad group among mir p mir p decreas mir p increas found mir p mir p mir p particip tgf beta pathway demonstr decreas mir p mir p increas mir p novel cad associ mirna tgf beta pathway find may pave way develop earli predict mirna biomark cad possibl develop therapeut tool field kidney transplant
|
D000074166;D016030;D035683
|
T061;T123;T114
|
36,293,109
|
blockad wnt secret attenu myocardi ischemia reperfus injuri modul inflammatori respons wnt portmanteau wingless int signal adult heart larg quiescent howev accumul evid get reactiv heal process myocardi infarct mi test therapeut potenti wnt secret inhibitor lgk mi heal ischemiareperfus ir injuri induc mice wnt signal inhibit oral administr porcupin inhibitor lgk transcriptom analyz infarct tissu use rna sequenc analysi inflammatori respons ir evalu flow cytometri heart function assess echocardiographi fibrosi masson trichrom stain transcriptom gene set enrich analysi reveal modul inflammatori respons upon administr wnt secret inhibitor lgk follow ir addit lgk treat anim show attenu inflammatori respons improv heart function vitro model hypox cardiomyocyt monocytemacrophag interact lgk inhibit activ wnt signal monocytesmacrophag reduc pro inflammatori phenotyp show wnt signal affect inflammatori process mi wnt secret inhibitor lgk appear promis compound futur immunomodulatori approach improv cardiac remodel mi
|
D015428;D009203
|
T047;T046
|
36,293,108
|
non canon function myeloperoxidas immun regul tissu inflamm cancer myeloperoxidas mpo one abund express protein neutrophil serv critic compon antimicrobi defens system facilit microbi kill via generat reactiv oxygen speci ros interest emerg evid indic addit well recogn canon antimicrobi function mpo direct indirect impact immun cell tissu respons homeostat diseas state highlight emerg non canon function mpo includ impact neutrophil longev activ traffick inflamm interact immun cell interact shape diseas outcom discuss mpo interact barrier form endotheli epitheli cell special cell central nervous system cns involv cancer progress divers function mpo associ numer inflammatori disord make attract target therapi aim resolv inflamm limit inflamm associ tissu damag howev consid mpo inhibit potenti therapi one must account divers impact mpo activ various cellular compart health diseas
|
D009195;D009369
|
T191;T126;T116
|
36,293,107
|
chitin synthesi yeast matter traffick chitin synthesi attract scientif interest decad essenti part fungal biolog potenti target antifung therapi interest remain three decad ago pioneer molecular studi chitin synthesi regul identifi major chitin synthas yeast chs authent paradigm field intracellular traffick integr membran protein year research shown intracellular traffick chs recapitul step intracellular traffick integr membran protein synthesi endoplasm reticulum degrad vacuol traffick includ specif mechan sort tran golgi network regul endocytosi endosom recycl differ level review summar work carri chitin synthesi regul most focus chs molecular model studi mechan involv control intracellular traffick protein
|
D012441;D029701
|
T004;T116
|
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