PMID
int64 35.7M
36.4M
| Title/Abstract
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36,293,106
|
vitamin c suppress pancreat carcinogenesi inhibit glucos metabol wnt signal cumul studi indic high dose vitamin c antitumor effect varieti cancer howev molecular mechan under inhibitori effect tumorigenesi metastasi particular relat pancreat cancer unclear report vitamin c high concentr impair growth surviv pancreat ductal adenocarcinoma pdac cell inhibit glucos metabol vitamin c also found trigger apoptosi caspas independ manner demonstr suppress invas metastasi pdac cell inhibit wnt catenin mediat epitheli mesenchym transit emt taken togeth result suggest vitamin c therapeut effect pancreat cancer
|
D021441;D010190
|
T191
|
36,293,105
|
mirna express may implic immunotherapi pdgfra mutant gist gastrointestin stromal tumor gist harbor mutat pdgfra gene occur patient common pdgfra mutat exon dv correl specif clinico patholog featur compar pdgfra mutat gist herein present mirna express profil comparison pdgfra dv mutant gist pdgfra mutat dv non dv mirna express profil carri patient use tlda mirna array mirna express follow bioinformat analysi aim evalu differenti express pathway enrich mirna mrna network highlight differenti express mirna dv non dv gist patient pathway enrich analysi show deregul mirna target gene main involv immun respons pathway mirna mrna network highlight signatur mirnasmrna could explain indol behavior dv mutat gist result highlight differ mirna fingerprint pdgfra dv gist compar non dvmutat patient could explain differ biolog behavior gist subset
|
D046152;D035683
|
T123;T191;T114
|
36,293,104
|
metabol regul lipidom remodel relat spermidin induc stress toler high temperatur plant benefici effect spermidin spd allevi abiot stress damag explor plant hundr year limit inform avail role regul lipid signal metabol heat stress white clover trifolium repen plant pretreat spd subject high temperatur c stress day investig effect spd heat toler transgen arabidopsi thaliana overexpress trsam encod key enzym involv spd biosynthesi expos high temperatur c stress day signific increas endogen spd content white clover exogen applic spd trsam overexpress arabidopsi thaliana could effect mitig heat induc growth retard oxid damag lipid declin photochem effici cell membran stabil base analysi metabolom amino acid vitamin metabol biosynthesi secondari metabolit lipid metabol main metabol pathway regul spd cool season white clover heat stress analysi lipidom found trsam transgen plant maintain relat higher accumul total lipid eight phospholipid pc phosphatidylcholin pg phosphatidylglycerol ps phosphatidylserin cl cardiolipin lpa lysophosphatid acid lpc lyso phosphatidylcholin lpg lyso phosphatidylglycerol lpi lyso phosphatidylinositol one glycoglycerolipid dgdg digalactosyl diacylglycerol four sphingolipid cer ceramid cerggnac dihexosyl n acetylhexosyl ceramid hexcer hexosyl ceramid st sulfatid higher ratio dgdg monogalactosyl diacylglycerol mgdg lower unsatur level wild type arabidopsi thaliana respons heat stress spd induc lipid accumul remodel could contribut better mainten membran stabil integr function plant underw long period heat stress addit spd signific regul pip pa signal pathway benefici signal percept transduct stress defens current find provid novel insight function spd heat stress regul lipid signal reprogram plant
|
D013095;D029921
|
T123;T002;T109
|
36,293,103
|
genom wide scan transcriptom analys character select chang result chlorantraniliprol resist plutella xylostella pesticid resist insect exampl adapt evolut occur pest speci driven artifici introduct pesticid diamondback moth dbm plutella xylostella lepidoptera plutellida evolv resist various insecticid understand genet chang underpin resist pesticid necessari implement pest control measur sequenc genom six resist six suscept dbm individu separ infer genom region greatest diverg strain use f st among sever genom region potenti relat insecticid resist cypb like observ signific diverg resist suscept strain missens mutat locat near substrat recognit site srs four snps promot character relat effect direct select via insecticid toler strain compar acut exposur insecticid treatment four pairwis comparison carri librari determin differenti express gene resist relat differenti express gene identifi comparison strain enrich pathway exogen detoxif includ cytochrom p abc transport confirm came weight gene co express network analysi indic gene signific modul associ chlorantraniliprol resist enrich pathway exogen detoxif cypb like repres hub gene darkr modul furthermor rnai knock cypb like increas p xylostella sensit chlorantraniliprol studi thus provid genet foundat under select pesticid resist plausibl mechan explain fast evolv adapt genom diverg alter gene express insect
|
D007306;D009036
|
T131;T204
|
36,293,102
|
elucid abil cgrp modul microvascular event mous skin oedema format polymorphonuclear leukocyt neutrophil accumul involv acut chronic inflamm calcitonin gene relat peptid cgrp sensori neuropeptid releas stimul sensori nerv cgrp potent vasodil neuropeptid especi administ cutan microvasculatur long durat action investig abil vasodil amount cgrp modul oedema format neutrophil accumul induc cutan microvasculatur mous learn mechan action endogen cgrp investig respons inflammatori stimul tumour necrosi factor alpha tnf carrageenan three differ murin model model sensori nerv deplet resiniferatoxin rtx pharmacolog method investig effect select cgrp receptor antagonist genet approach use wildtyp wt cgrp knockout ko mice result show exogen cgrp potenti oedema format induc substanc p sp tnf support find sensori nerv deplet mice absenc neuropeptid indic sensori nerv involv mediat oedema format neutrophil accumul induc tnf also carrageenan cutan microvasculatur furthermor endogen cgrp shown contribut inflammatori respons carrageenan induc oedema format attenu wt mice treat cgrp receptor antagonist cgrpko mice therefor conclud cgrp contribut inflamm promot oedema format skin respons depend pro inflammatori stimulus circumst
|
D015740;D009479
|
T125;T123;T116
|
36,293,101
|
transcript respons copper transport relat gene ctr ctr atox role regul cu homeostasi yellow catfish pelteobagrus fulvidraco character function ctr ctr atox promot yellow catfish pelteobagrus fulvidraco common freshwat teleost asian countri obtain bp bp bp sequenc ctr ctr atox promot predict key transcript factor bind site promot includ mre srebp nrf klf stat cu differenti influenc activ ctr ctr atox promot differ region found bp bp locus atox promot function nrf bind site negat control activ atox promot bp locus ctr promot bp bp locus atox promot function srebp bind site posit control activ ctr atox promot cu inhibit nrf bind abil atox promot promot srebp bind abil ctr atox promot dietari cu excess signific regul hepat mrna total protein express ctr ctr atox yellow catfish compar adequ dietari cu group subcellular local show ctr main local cell membran ctr cell membran lysosom atox cytoplasm conclus demonstr regulatori mechan three cu transport transcript level found function nrf srebp respons element ctr ctr atox promot provid new insight role regul cu homeostasi fish
|
D002397
|
T013
|
36,293,100
|
osteoclast driven osteogenesi bone remodel biomateri resorpt new profil bmp cpc induc alveolar bone regener bedsid bench studi aim systemat investig valu appli bmp load calcium phosphat cement bmp cpc restor larg scale alveolar bone defect compar deprotein bovin bone dbb bmp cpc shown capabl induc favor pattern bone regener bone remodel accompani activ osteoclastogenesi optim biomateri resorpt appli reconstruct periodont acceler osteogen orthodont paoo surgeri verifi regulatori role osteoclast bmp cpc induc pattern bone regener vitro vivo studi design elucid under mechan result reveal osteoclast play multifacet role facilit osteogenesi bone remodel biomateri resorpt bmp cpc induc bone regener osteoclast contribut osteogen differenti mesenchym stem cell mscs secret calcium ion cthrc pdgf b moreov increas osteoclast promot remodel new bone bmp cpc resorpt lead harmon replac biomateri matur bone conclus vitro vivo experiment result correspond clinic result show optim properti bmp cpc activ osteoclast driven bone regener remodel thus indic high promis prospect bmp cpc ideal therapeut alveolar bone defect
|
D010012;D010010
|
T025;T042
|
36,293,099
|
evolut influenza virus drug resist treatment option prospect viral evolut refer genet chang virus accumul lifetim aris adapt respons environment chang immun respons host influenza virus one rapid evolv microorgan genet instabl may lead larg chang biolog properti includ chang virul adapt new host even emerg infecti diseas previous unknown clinic cours genet variabl make difficult implement effect prophylact program vaccin may respons resist antivir drug aim review describ consequ variabl influenza virus mutat recombin allow virus overcom speci barrier caus epidem pandem anoth consequ influenza virus evolut risk resist antivir drug thus far one class drug protein inhibitor exclud use mutat strain isol mani region world human anim therefor effect anti influenza drug continu monitor refer center repres particular region world part epidemiolog surveil
|
D007251;D009975;D009980
|
T047;T005
|
36,293,098
|
dietari selenomethionin reduc mercuri tissu level modul methylmercuri induc proteom transcriptom alter hippocampi adolesc balbc mice methylmercuri mehg well known environment contamin particular harm develop brain main human dietari exposur mehg occur seafood consumpt howev seafood also contain sever nutrient includ selenium shown interact mehg potenti amelior toxic aim studi investig combin effect selenium selenomethionin semet mehg mercuri accumul tissu effect concomit dietari exposur compound exert hippocamp proteom transcriptom mice adolesc male balbc mice expos semet two differ dose mehg diet week organ includ brain sampl mercuri analys hippocampi collect analyz use proteom transcriptom follow multi omic bioinformat data analysi dietari presenc semet reduc amount mercuri sever organ includ brain proteom rna seq analys show protein rna express pattern invers regul mice receiv semet togeth mehg compar mehg alon sever pathway protein rna transcript involv condit immun respons inflamm oxid stress cell plastic alzheim diseas affect invers semet mehg indic semet amelior sever toxic effect mehg mice
|
D008767;D012643;D008628
|
T121;T123;T109;T131;T196
|
36,293,097
|
insight microbi communiti inhabit non volcan hot spring northwest spain abund non volcan hot spring recent use thermal activ one hot spring muio da veiga explor use metagenom studi microbi communiti inhabit high temperatur circumneutr continent water sequenc metagenom allow character composit divers metabol connect potenti sourc thermozym well abil assembl mag divers microbi communiti domin bacteria domain member reveal particular earli branch aquifical group abund genus sulfurihydrogenibium known implic sulfur cycl form mat enabl novel nich varieti primari produc autotroph pathway specif sulfur oxid pathway expand rang avail nutrient increas biomass form thicker mat result avail nich broader microbi divers nonetheless certain metabol pathway attribut less abund member microbi communiti reinforc idea rare biospher play import role network interact present ecosystem act genet reservoir addit three assembl mag repres novel microbi divers found hot spring moreov presenc enzym microorgan possibl biotechnolog applic confirm includ proteas lipas cell wall degrad enzym point potenti hot spring sourc thermozym
|
D045482;D064307
|
T001;T032;T070;T028
|
36,293,096
|
repurpos alon combin antivir saquinavir fluorouracil prostat lung cancer cell prostat lung cancer among common cancer type still need therapeut purpos saquinavir saq test alon combin fluorouracil fu pc cell expos increas concentr drug alon combin simultan sequenti administr cell viabil obtain use mtt assay synerg valu use compusyn softwar result show saq cytotox drug pc cell fu cytotox cell drug use combin synergist combin pc cell ic saq various concentr fu particular fu appli h later meanwhil promis combin fu delay saq weaker effect combin demonstr pc cell result demonstr saq could use new repurpos drug treatment prostat cancer treatment potenti could even greater saq combin anticanc drug fu lung cancer effici therefor much interest
|
D000970;D008175
|
T121;T191;T109
|
36,293,095
|
hydrogen sulfid repress methionin synthas slms act posit regul fruit ripen tomato ethylen key phytohormon regul ripen climacter fruit methionin indirect precursor ethylen howev whether methionin synthas play role fruit ripen solanum lycopersicum tomato still unknown studi find tomato methionin synthas name slms could repress transcript level hydrogen sulfid h act posit regul tomato fruit ripen bioinformat analysi found slms slms tomato high homolog methionin synthas arabidopsi thaliana express pattern slms slms analyz tomato slms express regul fruit ripen suggest potenti role regul fruit ripen potenti bipartit nuclear local signal found amino acid sequenc slms thus slms tag gfp observ leav nicotiana benthamiana consist slms gfp show strong nuclear local also cytoplasm local role slms regul fruit ripen investig tomato fruit transient silenc virus induc gene silenc vig transient overexpress result show slms silenc caus delay fruit ripen evidenc chlorophyl less carotenoid accumul slms overexpress acceler fruit ripen signific compar control investig show slms overexpress could regul express carotenoid synthesi relat gene psi pds zds chlorophyl degrad relat gene nyc pao pph sgr cell wall metabol relat gene cel exp pg tbg xth ethylen synthesi pathway relat gene aco aco ac slms silenc caus opposit result correl analysi indic slms express negat correl chlorophyl content posit correl carotenoid ripen relat gene express taken togeth data suggest slms posit regul tomato fruit ripen possibl target gene ripen delay effect h
|
D018551;D006862
|
T168;T197;T131;T130;T002
|
36,293,094
|
anticoagul potenti sar cov pro inhibitor covid patient vitro molecular dock molecular dynam dft sar studi articl anticoagul drug screen silico main proteas pro sar cov use molecular dock tool idraparinux fondaparinux eptifibatid heparin ticagrelor demonstr highest bind affin toward sar cov pro molecular dynam studi ns also carri promis anticoagul provid insight dynam thermodynam properti promis compound moreov quantum mechan studi also conduct help us attest molecular dock dynam find biolog evalu vitro promis compound also perform carri mtt cytotox assay crystal violet assay order assess inhibitori concentr ic worth note ticagrelor display highest intrins potenti inhibit sar cov ic valu safeti index addit fondaparinux sodium dabigatran show promis inhibitori activ ic valu respect demonstr safeti index respect moreov inhibitori potenti sar cov pro enzym investig util sar cov pro assay use tipranavir refer standard interest promis sar cov pro inhibitori potenti attain fondaparinux sodium ic valu surpass refer tipranavir ic three fold furthermor high elig sar cov pro inhibitori potenti attain dabigatran ic valu final sar discuss count find vitro silico approach
|
D000086402;D000086382
|
T005;T067;T047
|
36,293,093
|
impact cholesterol oxysterol cholesterol lower dietari compound immun system cholesterol oxid form oxysterol ingest food synthes de novo cholesterol oxysterol influenc molecular cellular event subsequ biolog respons immun cell amount dietari cholesterol influenc level ldl cholesterol blood oxysterol play signific role induct pro inflammatori state immun cell lead inflammatori disord includ cardiovascular diseas cholesterol oxysterol synthes de novo immun cell stroma cell involv immun homeostasi may also influenc excess intak dietari cholesterol dietari compound glucan plant sterolsstanol omega lipid polyphenol soy protein could lower blood cholesterol level interf cholesterol absorpt metabol dietari compound also potenti exert immun modul divers mechan review address current knowledg impact dietari deriv de novo synthes cholesterol oxysterol immun system possibl immunomodulatori mechan elicit cholesterol lower dietari compound also discuss
|
D000072376;D010840;D047071
|
T123;T121;T109
|
36,293,092
|
one step forward dri surfac biofilm dsb staphylococcus aureus tmt base quantit proteom analysi reveal proteom shift dsb hydrat biofilm gram posit bacterium staphylococcus aureus respons serious acut chronic infect worldwid well known biofilm format abil recent find biofilm dri hospit surfac emphasis failur current clean practic disinfect difficulti remov dri surfac biofilm dsbs mani aspect format complex dsb biolog environment surfac healthcar set remain limit present studi aim determin protein compon vari dsbs tradit hydrat biofilm biofilm grown tryptic soy broth tsb remov polycarbon coupon cdc biofilm reactor day hydrat biofilm tsb h media chang everi h tsb c rpm dsb biofilm produc tsb h c follow extend period dehydr h room temperatur interspers h tsb c construct comprehens refer map day dsb day hydrat biofilm associ protein aureus use high throughput tandem mass tag tmt base mass spectrometri pathway analysi signific differenti express identifi protein reveal protein signific upregul day dsb includ pts glucos transport subunit iibc ptaa udp n acetylmuram l alanin ligas murc udp n acetylenolpyruvoylglucosamin murb compar day hydrat biofilm three protein link peptidoglycan biosynthesi pathway respons cell wall format thicker ep matrix deposit increas cell wall format may contribut persist dsb dri surfac contrast protein associ energi metabol phosphoribosyl transferas pyrr glucosamin fructos phosphat aminotransferas glms galactos phosphat isomeras laca argininosuccin synthas argg signific upregul wherea ribosom abc transport signific downregul day hydrat biofilm compar dsb howev valid qpcr analysi show level gene express identifi partial line tmt ms quantit analysi first time tmt base proteom studi dsb shed novel insight provid basi identif studi signific pathway vital biofilm biolog refer microorgan
|
D013211;D013203
|
T047;T007
|
36,293,091
|
arrestin grks regul function long chain fatti acid receptor ffa ffa two g protein coupl receptor activ long chain fatti acid play crucial role mediat mani biolog function bodi result fatti acid receptor gain consider attent due potenti target treatment type diabet howev relat contribut canon g protein mediat signal versus effect agonist induc phosphoryl interact arrestin yet fulli defin recent sever report highlight abil arrestin grks interact modul differ function ffa ffa suggest inde import consid interact studi role ffa ffa normal physiolog differ diseas set discuss current known show import understand fulli arrestin grks regul function long chain fatti acid receptor
|
D019390;D054768
|
T123;T126;T116
|
36,293,090
|
compar analysi antibodi titer spike protein sar cov variant infect patient cohort divers vaccin regim presenc neutral antibodi sar cov correl protect infect sever covid diseas cours understand dynam antibodi develop sar cov virus import recommend vaccin strategi control covid pandem studi investig dynam extent spike ab develop differ vaccin manufactur johnson johnson astrazeneca pfizer biontech moderna day vaccin observ tempor low grade inflammatori respons spike ab titer reduc six month vaccin mrna vaccin increas day booster vaccin maximum exceed titer mild critic covid long covid patient within group critic covid patient observ trend lower spike ab titer group patient surviv covid trend accompani higher number pro b cell fewer matur b cell higher frequenc follicular helper cell final present data demonstr past infect mild covid lead long term increas ab titer even group previous infect sar cov patient benefit vaccin six month infect
|
D000086402;D000086382
|
T005;T067;T047
|
36,293,089
|
hydrogen bond drive helic chiral via member ring dipeptid conjug ferrocen diamin consid enorm import protein turn particip various biolog event protein protein interact great effort made develop conform proteolyt stabl mimet ferrocen diamin previous shown nucleat stabl turn structur peptid prepar conjug ala iii ala pro vi prepar homochir conjug ferrocen diamin l phe l val l leu investig whether organometal templat induc turn structur upon conjug amino acid whether bulki branch side chain phe val leu affect hydrogen bond detail spectroscop ir nmr cd x ray dft studi reveal presenc two simultan member interstrand hydrogen bond ie two simultan turn goal compound preliminari biolog evalu leu conjug show modest potenti induc cell cycl arrest gg phase hela cell line result need investig
|
D003959;D004151
|
T116;T109
|
36,293,088
|
lipofuscin mediat photic stress induc dark toxic effect arp cell lipofuscin granul retin pigment epithelium rpe cell contain bisretinoid fluorophor photosensit phototox cell presenc oxygen bisretinoid oxid form various product contain aldehyd keton also potenti cytotox prior studi identifi bisretinoid oxid degrad product hydrophil amphiphil properti allow diffus lipofuscin granul membran rpe cell cytoplasm thiobarbitur acid tba activ purpos present studi determin product exhibit toxic effect rpe cell also absenc light experi perform use lipofuscin fed arp cell cultur rpe cell viabil analysi perform use flow cytofluorimetri laser scan confoc microscopi result obtain indic cell viabil lipofuscin fed arp sampl clear reduc immedi visibl light irradi h day maintain dark consequ could conclud bisretinoid oxid product damag effect rpe cell dark consid aggrav factor age relat macular degener progress
|
D008062;D017319
|
T123;T039;T121;T109
|
36,293,087
|
compon complement cascad differ polycyst ovari syndrom complement pathway protein report increas polycyst ovari syndrom pcos may affect obes insulin resist investig proteom analysi complement system undertaken includ inhibitori protein cohort studi plasma collect women pcos control somalog proteom analysi undertaken follow complement system protein cq cr c c ca icb cb cd cadesarg c ca cb c ca cb complex c properdin factor b factor factor h factor mannos bind protein c mbl complement decay acceler factor daf complement factor h relat protein cfhr altern pathway complement system primarili overexpress pcos increas c p lt properdin factor b p lt addit inhibit pathway also seen pcos increas cfhr factor h factor p lt downstream complement factor icb cd associ enhanc b cell respons ca associ inflammatori cytokin releas increas p lt hyperandrogenemia correl posit properdin icb whilst insulin resist homa ir correl icb factor h p lt pcos bmi correl posit cd factor b factor factor cfhr ca p lt comprehens evalu complement system pcos reveal upregul compon complement system appear offset concurr upregul inhibitor chang account part bmi hyperandrogenemia insulin resist
|
D037601;D011085;D007333
|
T121;T047;T046;T116
|
36,293,086
|
genom wide identif ch zfps function analysi brzat low temperatur stress winter rapese brassica rapa zinc finger protein zfp transcript factor among largest famili transcript factor plant particip various biolog process apoptosi autophagi stem mainten play import role regul plant growth develop respons stress elucid function zfp gene low temperatur respons winter brassica rapa l b rapa studi identifi member ch zfp gene famili b rapa heterogen distribut chromosom multipl cis act element relat hormon regul abiot stress advers gene famili contain one cds gene distribut evolutionari branch share most motif high conserv evolut crucifer speci gene signific upregul root growth cone longyou indic play role stress respons process winter b rapa express level bra gene higher strong cold resist varieti weak cold resist varieti low temperatur stress surviv rate brzat gene express tran brzat arabidopsi thaliana arabidopsi signific higher wild type plant low temperatur enzym activ vivo higher wild type plant indic brzat gene could improv cold resist winter b rapa brzat express superoxid dismutas ascorb peroxidas enzym activ upregul winter b rapa exogen aba treatment brzat express enzym activ decreas pd treatment brzat express enzym activ higher pd treatment lower control treatment togeth specul brzat play role aba signal process mapkk involv studi provid theoret basi resolut cold resist mechan strong winter b rapa
|
D029741;D029688;D017360
|
T168;T002
|
36,293,085
|
transcriptom analysi reveal gene pathway associ salt toler seed germin suaeda liaotungensi seed germin suscept extern environment factor especi salt stress suaeda liaotungensi halophyt strong salt toler germin rate brown seed mm nacl treatment still reach explor mechan salt stress respons brown seed germin suaeda liaotungensi conduct transcriptom analysi dri seed sld germin seed control condit slgc salt treatment slgn transcriptom analysi reveal differenti express gene deg sld vs slgc slgc vs slgn detect respect deg enrich pathway relat transcript regul hormon signal transduct ros metabol cell wall organ biogenesi carbohydr metabol process two contrast group compar control condit pod cat activ h solubl sugar prolin content increas germin seed salt stress furthermor function analysi demonstr overexpress slnac signific enhanc salt toler germin stage arabidopsi result reveal toler mechan brown seed germin respons salin stress also promot explor applic salt toler gene resourc suaeda liaotungensi
|
D019663;D017360
|
T002
|
36,293,084
|
genotyp complement phenotyp identif pathogen lmna splice variant nanopor long read sequenc larg dcm famili dilat cardiomyopathi dcm common caus heart failur hf famili origin case genet test next generat sequenc ngs yield definit diagnosi mani case howev remain elus studi use combin ngs human induc pluripot stem cell deriv cardiomyocyt ipsc cms nanopor long read sequenc identifi causal variant multi generat pedigre dcm four generat famili famili dcm investig next generat sequenc ngs perform famili member skin biopsi two affect famili member use generat ipsc differenti ipsc cms short read rna sequenc use evalu target gene express long read rna nanopor sequenc use evalu relev splice variant pedigre suggest high penetr autosom domin mode inherit phenotyp famili suggest laminopathi previous genet test use sanger panel sequenc yield conflict evid lmna prc rs fulli segreg sequenc four addit affect famili member non code lmna variant could detect rs rs rs rs explor role variant ipsc cms generat rna sequenc show lmna express level signific lower ipsc cms lmna variant carrier demonstr dysregul sarcomer structur alter calcium homeostasi ipsc cms lmna variant carrier use target nanopor long read sequenc reveal biolog signific variant cg gt generat novel splice site exon cardiac isom lmna caus nonsens mrna product almost complet rna decay haploinsuffici use novel molecular analysi nanopor technolog demonstr pathogenesi rs cg gt splice variant lmna studi highlight import precis diagnost clinic manag workup cardiomyopathi
|
D002311;D000081414;D058608
|
T063;T047;T082
|
36,293,083
|
biolog activ differ form oxid parathyroid hormon preclin studi shown parathyroid hormon pth lose biolog effect oxid pth oxid methionin three possibl variat oxid pth oxpth exist met ox pth met ox pth met met di ox pth recent studi show met ox pth retain biolog activ abl upregul fgf gene express wherea met ox pth met met di ox pth show less biolog activ earlier studi likewis show oxid met minor effect secondari structur pth wherea oxid met caus substanti structur chang consist anoth studi show oxid met block generat second messeng camp wherea effect oxid met much less potent inhibit camp format consider percentag circul pth chronic kidney diseas ckd patient oxid howev know relat amount differ form oxpth agonist partial agonist even antagonist biolog action differ ckd popul might explain differ clinic find differ ckd popul analyz far current avail method use clinic studi distinguish oxpth noxpth without abl differenti differ form oxpth method pth measur abl differenti pth form noxpth met ox pth met ox pth met met di ox pth potenti improv patient care method definit separ bioactiv non bioactiv pth form method need develop valid use prospect random clinic trial defin potenti valu bioactiv pth form predictor cardiovascular event mortal bone turnov
|
D010281;D051436
|
T123;T121;T116;T125;T047
|
36,293,082
|
comprehens genom wide analysi express pattern profil slhva gene famili unravel like involv abiot stress adapt tomato hva famili protein conserv tbdphva domain ubiquit eukaryot hva famili gene identifi varieti plant speci howev comprehens genom wide analysi hva famili gene tomato solanum lycopersicum l identifi non redund slhva gene three segment duplic gene pair tomato chromosom predict three dimension model gene ontolog go annot slhva protein point putat transport activ abil bind divers ligand co express slhva gene various gene implic multipl metabol pathway local slhva gfp fuse protein endoplasm reticulum suggest might varieti biolog function includ vesicular transport stress cell comprehens express analysi reveal slhva gene differenti express various organ respons abiot stress condit predomin express slhvai ripen stage slhvag slhvak slhval fruit development stage suggest probabl involv tomato fruit develop ripen moreov transcript express tomato hva gene particular slhvab slhvai slhvak slhval slhvam slhvan affect abscis acid aba divers abiot stress treatment indic like involv gene tomato abiot stress respons aba depend manner overal find provid foundat better understand structur function role slhva gene mani might use improv abiot stress toler fruit qualiti tomato marker assist backcross transgen approach
|
D018551
|
T168;T002
|
36,293,081
|
androgen respons oncogen lncrna rp l enhanc c myc protein stabil prostat cancer long noncod rnas lncrnas found novel particip pathophysiolog prostat cancer pca predomin regul androgen receptor biolog function androgen respons lncrnas remain poor understood identifi lncrna rp l high express pca rp l express direct repress androgen receptor pca cell rp l deplet inhibit prolifer migrat cell cycl progress promot apoptosi pca cell indic rp l act oncogen pca cell microarray result reveal rp l deplet downregul c myc transcript signatur pca cell rp l deplet induc cellular phenotyp overcom ectop overexpress c myc mechanist rp l repress fbxo mrna express therebi enhanc c myc protein stabil block fbxo mediat c myc degrad find reveal previous unrecogn role rp l c myc depend pca tumorigenesi
|
D062085;D011471
|
T123;T191;T114
|
36,293,080
|
granul bismuth oxid algin effici remov iodid water granul bismuth oxid bo algin alg iodid adsorpt efficaci alg bo differ initi iodid concentr contact time valu examin optim condit alg bo granul identifi control weight ratio alg bo accord batch iodid adsorpt experi alg bo weight ratio appropri yield uniform spheric shape accord iodid adsorpt isotherm experi isotherm model fit maximum sorption capac q calcul mgg base langmuir isotherm valu plateau even initi iodid concentr mgl furthermor iodid adsorpt alg bo occur monolay adsorpt chemic interact precipit bismuth iodid follow physic multilay adsorpt high concentr iodid solut iodid adsorpt time fit use intraparticl diffus model result indic iodid adsorpt proceed boundari layer diffus min reach plateau min min intraparticl diffus accord imag obtain use cross section scan electron microscopi assist energi dispers spectroscopi adsorb iodid interact bo alg bo bi complex research show alg bo promis iodid adsorb owe high adsorpt capac stabil conveni abil prevent secondari pollut
|
D000464;D014874
|
T121;T122;T131;T109
|
36,293,079
|
transcriptom analysi reveal gene relat pollen abort cytoplasm male steril soybean glycin max l merr cytoplasm male steril cms lay foundat util heterosi soybean soybean cms line sxcmsa excel cms line exhibit male steril cytolog analysi reveal sxcmsa compar maintain sxcmsb tapetum vacuol abnorm develop identifi gene metabol pathway involv pollen abort sxcmsa compar transcriptom analysi conduct sxcmsa sxcmsb use flower bud total high qualiti clean read obtain sampl replic materi differenti express gene deg identifi includ downregul upregul one sxcmsa compar sxcmsb among deg ie open read frame orf cox mitochondri genom gene orf orfc upregul cms line transmembran domain therefor identifi cms candid mitochondri gene sxcmsa furthermor numer deg associ pollen wall develop carbohydr metabol sugar transport reactiv oxygen speci ros metabol transcript factor confirm quantit real time pcr analysi cms line cytoplasm sourc sxcmsa respect maintain line amount solubl sugar adenosin triphosph activ catalas ascorb acid oxidas show energi suppli ros scaveng decreas sxcmsa compar sxcmsb find provid valuabl inform understand molecular mechan regul pollen abort soybean cms
|
D013025;D051479
|
T045;T168
|
36,293,078
|
regul cre depend transcript activ mous suprachiasmat nucleus cell line evalu signal framework immort cell hypothalam suprachiasmat nucleus scn mous select vasoact intestin peptid vip posit sub clone immort mous scn cell stabli express camp regul element cre luciferas construct name scncre character cell term status neuron cell well import compon camp depend signal transduct pathway compar scn ex vivo scncre cell treat agent modul differ intracellular signal pathway investig potenc time transcript cre depend signal sever activ pathway modul scn neuron signal via camp regul element cre tgacgcta phosphoryl transcript factor camp regul element bind protein creb cre luciferas activ induc differ camp signal pathway modul agent display varieti substanc specif dose time depend profil interact relev regul scn physiolog moreov induct protein kinas c pkc pathway phorbol ester applic modul cre depend signal pathway well conclus camppka pkc regul pathway individu combin modul final cre depend transcript output
|
D014660;D000074523
|
T125;T116;T025
|
36,293,077
|
prolong febril seizur impair synapt plastic alter development pattern glial fibrillari acid protein gfap immunoreact astrocyt hippocampus young rat prolong neonat febril seizur fss often lead cognit declin increas risk psychopatholog adulthood howev neurobiolog mechan under long term advers effect fss remain unclear studi expos rat pup hyperthermia induc fss last least min investig short term one day delay day effect fss paramet morpholog function matur hippocampus notic fss alter development pattern glial fibrillari acid protein gfap immunoreact rat age day gfap posit astrocyt cover smaller area morpholog characterist resembl rat day age post fs rat magnitud long term synapt potenti reduc compar control anim age appli gliotransmitt serin agonist glycin site nmda receptor restor ltp control valu decreas ltp amplitud correl impair spatial learn memori barn maze task post fs rat data suggest impair neuron glia interact may essenti mechan advers effect fs develop brain
|
D003294;D013226;D004827
|
T033;T047
|
36,293,076
|
miner bone disord kidney diseas patient ever current topic chronic kidney diseas ckd complex multifactori diseas one preval worldwid chronic kidney diseas miner bone disord ckd mbd biochem hormon alter part complic associ progress ckd pathophysiolog ckd mbd focus abnorm serum level sever biomark fgf klotho phosphat calcium vitamin pth discuss review therefor examin prognost associ ckd mbd increas risk cardiovascular event mortal ckd progress end stage kidney diseas eskd last present specif treatment act ckd prevent treat complic associ secondari hyperparathyroid shpt control hyperphosphatemia dietari restrict intestin phosphat binder adequ dialysi use calcimimet agent vitamin analogu use bisphosphon denosumab patient osteoporosi
|
D012080;D001847;D051436
|
T047
|
36,293,075
|
alter circul follicular helper cell subset follicular regulatori cell indic derail b cell respons lupus could modifi target il r system lupus erythematosus sle character breakdown self toler product high affin pathogen autoantibodi derail b cell respons indic import central player follicular helper fh subset follicular regulatori fr cell pathomechan diseas studi aim analyz distribut circul counterpart cell associ diseas characterist b cell disproport sle found increas percentag activ circul fh ct fh ct fr cell pronounc cutan lupus howev among ct fh subset frequenc ct fh cell decreas patient lupus nephriti furthermor decreas proport ct fh cell associ low complement c level high diseas activ score also investig whether block il receptor il r anti il r monoclon antibodi inhibit b cell respons sinc il primarili produc fh cell potenti promot humor immun observ anti il r inhibit plasmablast generat immunoglobulin product studi demonstr besid ct fr ct fh imbal ct fh cell play crucial role sle pathogenesi modul ct fh b cell interact il il r pathway may promis therapeut strategi suppress patholog b cell respons
|
D053655;D008180
|
T047;T116;T192
|
36,293,074
|
blockad platelet cysltr receptor zafirlukast counteract platelet protumor action prevent breast cancer metastasi bone lung metastas main caus death cancer patient platelet larg known contribut cancer progress howev target platelet high challeng given paramount function hemostasi use high throughput screen platelet induc breast tumor cell surviv pitc assay endpoint identifi wide use anti asthmat drug cysteinyl leukotrien receptor cysltr antagonist zafirlukast montelukast new specif blocker platelet protumor action show human mda b breast cancer cell produc cyslt mechan involv microsom glutathion transferas mgst modul cancer cell platelet interact via platelet cysltr cysltr blockad zafirlukast decreas platelet aggreg adhes cancer cell inhibit pitc migrat invas vitro zafirlukast signific reduc mda b cell dissemin bone nude mice reduc spontan lung metastasi format without affect primari tumor growth combin treatment zafirlukast plus paclitaxel total inhibit metastasi cell lung altogeth result reveal novel pathway mediat crosstalk cancer cell platelet indic platelet cysltr repres novel therapeut target prevent metastasi without affect hemostasi
|
D001943;D018927
|
T121;T191
|
36,293,073
|
polyclon aptam librari fluroot selex specif label apic elongationdifferenti zone arabidopsi thaliana root year aptam research becom wide accept aptam fascin bind molecul vast varieti applic howev major target protein although special variant call selex process molecular evolut specif aptam also develop allow target small molecul well larger structur cell even cellular network human tumor tissu although provoc thesi wide accept field principl level complex selex target possibl number studi whole organ least part limit pioneer thesi base flucel selex process develop polyclon aptam librari apic elongationdifferenti zone plant root exampl organ show dedic librari specif label respect part root allow us distinguish fluoresc microscopi consid achiev initi import evid robust selex variant librari may valuabl tool plant research promis start point isol specif individu aptam direct root specif epitop
|
D052157;D017360
|
T002;T114
|
36,293,072
|
defens mechan cotton fusarium verticillium wilt comparison pathogen respons cotton human cotton import econom crop fusarium verticillium primari pathogen fungi threaten qualiti sustain product cotton opportunist pathogen fusarium caus various human diseas includ fungal kerat common therefor urgent need studi clarifi resist mechan cotton human toward fusarium order mitig elimin harm herein first discuss resist suscept mechan cotton fusarium verticillium wilt classifi associ gene base function outlin characterist pathogen fusarium describ multipl role human neutrophil limit hyphal growth final comprehens compar similar differ anim plant resist fusarium put forward new insight novel strategi cotton diseas resist breed treatment fusarium infect human
|
D020172;D005670
|
T004
|
36,293,071
|
cell junction vesicl traffick mediat melanosomemelanin transfer involv dynam transform goldfish carassius auratus skin color goldfish one popular model studi genet divers skin color transcriptom sequenc rna seq whole genom bisulf sequenc wgbs skin tissu third filial f cyan cn black bk white wh goldfish conduct analyz molecular mechan color transform fish rna seq yield gb clean data transcript nine skin sampl deg differenti express gene enrich cell junction cellular compon tight junction pathway nineti five homolog claudin famili predict claudin identifi correl skin color transform wgbs yield gb clean data sampl deg dmrs differenti methyl region bkcn group found enrich cytoskeleton reorgan vesicl traffick masson stain tem transmiss electron microscopi confirm vari distribut process melanosomemelanin skin tissu result suggest cytoskeleton reorgan cell junction vesicl traffick system play key role transfer melanosomemelanin extracellular transloc rather biosynthesi metabol melanin process result color transform cyan goldfish data facilit understand molecular mechan under dynam skin color transform goldfish
|
D006054;D012868
|
T019;T013
|
36,293,070
|
engin human intervertebr disc model induc degen microgli proinflamm degener intervertebr disc ivd major contributor low back pain lbp ivd degener character abnorm product inflammatori cytokin secret ivd cell although under molecular mechan lbp elucid increas evid suggest lbp associ particular microglia ivd tissu peridisc space aggrav cascad degen event studi implement microfluid chemotaxi platform investig microgli inflamm respons reconstitut degen ivd model ivd model construct stimul human nucleus pulposus np cell interleukin produc interleukin fold interleukin fold c c motif chemokin ligand ccl fold ccl fold measur microgli chemotaxi p lt toward condit media ivd model addit observ consider activ neurodegen deactiv protect microglia via upregul express cdb p lt regul cd protein p lt solubl factor ivd model turn enhanc inflammatori milieu ivd tissu caus matrix degrad cellular damag find indic degen ivd may induc degen microgli proinflamm lead lbp develop
|
D055959;D007403;D017116
|
T184;T047;T023;T190
|
36,293,069
|
aluminum arsenic beryllium cadmium chromium cobalt copper iron lead mercuri molybdenum nickel platinum thallium titanium vanadium zinc molecular aspect experiment liver injuri experiment liver injuri hepatocelluar necrosi abnorm liver test caus exposur heavi metal hms like aluminum arsenic beryllium cadmium chromium cobalt copper iron lead mercuri molybdenum nickel platinum thallium titanium vanadium zinc pollut hms disturb ecosystem substanc toxic may affect health human anim hms biodegrad may deposit preferenti liver use anim model help identifi molecular mechanist step lead injuri hms common initi hepatocellular overproduct ros reactiv oxygen speci due oxid stress result coval bind radic macromolecular protein lipid exist membran subcellular organell liver injuri facilit iron via fenton reaction provid ros trigger protect antioxid system exhaust ferroptosi syn pyroptosi recent introduc mechanist concept explan nickel ni liver injuri nicl caus increas iron deposit liver upregul cyclooxygenas cox protein mrna express level downregul glutathion eroxidas gpx ferritin heavi chain fth nuclear receptor coactiv ncoa protein mrna express level nickel may caus hepat injuri mitochondri damag ferroptosi defin mechan iron depend cell death similar glutam induc excitotox like distinct apoptosi necrosi autophagi discuss addit mechanist concept hepatocellular uptak biliari excret mercuri expos anim instanc organ anion transport oat multidrug resist associ protein mrp involv hepat handl mercuri mercuri treatment modifi express mrp oat assess immunoblot partial explain impair biliari excret concomit decreas oat abund hepatocyt plasma membran observ limit hepat uptak mercuri ion import shown first time liver injuri caus hms titanium chang divers gut microbiota modifi metabol function lead increas generat lipopolysaccharid lps endotoxin lps may trigger perpetu liver injuri level gut liver sum mechanist molecular step experiment liver injuri due hm administr complex ros key promot compound howev addit concept iron use fenton reaction ferroptosi modif transport system endotoxin deriv divers intestin bacteria gut liver level merit consider
|
D001151;D008628;D019216;D004785;D027361
|
T121;T123;T116;T131;T196
|
36,293,068
|
matern fructos intak program mitochondri function predisposit adult diseas fructos consumpt recognis major risk factor develop metabol diseas hyperlipidaemia diabet non alcohol fatti liver diseas obes addit environment social genet factor unfavour intrauterin environ also recognis import factor progress suscept metabol diseas adulthood development trajectori short term respons nutrient restrict excess nutrient avail may promot adapt serv maintain organ function necessari immedi surviv foetal develop consequ may lead decreas function organ system present unfavour neonat adolesc andor adult nutrit environ earli event may exacerb suscept later life diseas sinc sub optim matern nutrit increas risk non communic diseas ncds futur generat earlier dietari intervent implement pregnant mother consid pregnanc may ad benefit although mechan matern diet high fructos vertic transmiss matern metabol phenotyp may lead predisposit adult diseas poor understood review discuss potenti contribut excess fructos intak pregnanc may lead development reprogram mitochondri function predisposit metabol diseas offspr
|
D008659;D011297
|
T047;T037
|
36,293,067
|
comprehens assess qualit quantit prodrom parkinsonian featur carrier gaucher diseas identifi greatest risk carrier gba gene variant signific risk develop parkinson diseas pd cohort studi gba carrier year age initi studi presenc prodrom pd featur particip underw non invas test assess differ domain pd nineti eight unrel gba carrier enrol male median age rang year carri ns variant ca gt g posit famili histori pd montreal cognit assess moca frequent abnorm ci follow ultrasound hyperechogen ci unifi parkinson diseas rate scale part iii updr iii ci smell assess ci abnorm sleep questionnair ci signific correl found test differ domain defin risk pd assess bottom th percentil prodrom test defin level abnorm calcul percentag abnorm test subject median rang twenti two subject abnorm test limit studi includ ascertain bias individu gba relat pd relat incomplet data due technic issu lack well character normal valu rang test plan enrol addit particip conduct longitudin follow assess build model identifi individu risk pd investig intervent aim delay onset perhap prevent full blown pd
|
D005776;D010300
|
T047
|
36,293,066
|
culturom investig endometri microbiom proof concept microbiom reproduct tract associ sub fertil suggest dysbiosi reduc success rate pregnanc outcom endometri microbiom particular interest given potenti impact embryo implant date endometri microbiom studi appli metagenom approach sequenc base techniqu howev limit specif adequ explor low biomass set intra uterineendometri sampl proof concept studi demonstr applic culturom high throughput cultur approach investig endometri microbiom ten subfertil women undergo diagnost hysteroscopi endometri biopsi part routin work brussel ivf includ inform consent biopsi use cultur microbiota day multipl aerob anaerob condit subsequ wasplab assist culturom enabl standard methodolog matrix assist laser desorptionion time flight mass spectrometri maldi tof ms rrna sequenc appli identifi bacteri fungal isol eighti three bacteri two fungal speci identifi detect speci concord previous publish metagenom base endometri microbiota analys belong previous describ genera nevertheless highlight ad valu culturom identifi isol speci level identifi speci describ endometri microbiota first time studi show applic ad valu wasplab assist culturom investig low biomass endometri microbiom speci level
|
D064307
|
T001;T032;T028
|
36,293,065
|
prospect test diurnal profil express tsh r circadian clock gene thyrocyt identif preoper biomark thyroid carcinoma thyroid nodul tn frequent most benign postop rate benign tn attain valu therefor urgent need identif reliabl preoper diagnosi marker patient indetermin thyroid cytolog studi earlier unexplor design research preoper biomark thyroid malign propos evalu report result studi address link thyroid cancer circadian clockwork dysfunct abnorm activ thyroid stimul hormon tsh receptor tsh r suggest diagnost signific link howev still gap studi interrelationship diurnal profil express circadian clock gene tsh r indetermin thyroid tissu expos differ concentr tsh interrelationship might investig futur vitro experi benign malign thyrocyt cultiv normal challeng tsh level design requir simultan measur diurnal profil express circadian clock gene tsh r experiment result might help bridg previous studi preoper biomark thyroid carcinoma explor diagnost valu diurnal profil serum tsh level express tsh r express circadian clock gene
|
D057906;D000072637;D013964
|
T040;T191;T025
|
36,293,064
|
wnt signal age gastrointestin tract age consid risk factor various diseas includ cancer age societi urgent need clarifi molecular mechan involv age wnt signal shown play crucial role mainten differenti tissu stem cell intens studi elucid pivot role age neural muscl stem cell howev recent studi gastrointestin tract limit review discuss recent advanc studi role wnt signal age gastrointestin tract age relat carcinogenesi
|
D060449;D051153
|
T123;T116;T044
|
36,293,063
|
esmethadon rel uncompetit nmdar channel blocker may improv mood disord via modul synapt kinas mediat signal articl present mechan action hypothesi explain rapid antidepress effect esmethadon rel uncompetit n methyl aspart receptor nmdar antagonist present correspond mechan diseas hypothesi major depress disord mdd esmethadon uncompetit nmdar antagonist may restor physiolog neural plastic anim model depress like behavior patient mdd via preferenti tonic block patholog hyperact glund subtyp tonic ca current via glund subtyp regul homeostat avail synapt protein mdd depress behavior may determin reduc homeostat avail synapt protein due upregul tonic ca current glund subtyp preferenti activ low potenc nmdar antagonist glund subtyp may explain rapid antidepress effect absenc dissoci side effect
|
D003865
|
T048
|
36,293,062
|
genet mechan tissu specif express ppar gene turbot scophthalmus maximus differ temperatur studi use pcr measur level peroxisom prolifer activ receptor gene ppar ppar ppar ppar intestin liver gill heart kidney brain muscl spleen skin stomach turbot scophthalmus maximus cultur differ temperatur condit c use split split plot ssp analysi varianc addit main effect multipl interact ammi analysi genotyp main effect genotyp environ interact gge biplot analysi evalu genotyp tissu interact effect gene express result ssp analysi varianc show temperatur tissu gene high signific p lt effect express maximus amp nbsp ppar gene ammi analysi result reveal express ppar gene appropri temperatur c main depend genotyp tissu interact tissu effect stress temperatur genotyp effect tissu effect genotyp tissu interact signific effect express ppar gene contribut genotyp effect slowli increas increas temperatur increas faster c slowli declin c contribut tissu effect slowli increas c sharpli decreas stabil slight fluctuat contribut genotyp tissu interact effect show fluctuat upward trend throughout experi signific impact ppar gene express key temperatur three effect chang c indic limit temperatur activ lipid metabol high temperatur stress gge biplot analysi result show suitabl water temperatur express differ ppar gene liver largest c express differ gill largest c express differ brain largest overal result suggest mechan respons ppar gene express three high temperatur c relat consist differ c
|
D005412;D048068
|
T192;T116;T013
|
36,293,061
|
bind gamma glutamyl transferas tlr signal allow tissu factor activ monocyt gamma glutamyl transferas ggt involv progress atherosclerosi sinc enzymat activ promot generat reactiv oxygen speci ros besid ggt may act prothrombot factor induc tissu factor tf express independ enzymat activ aim studi assess whether ggt induc tf stimul consequ bind toll like receptor tlr express monocyt precursor macrophag foam cell coloc ggt activ within atherosclerot plaqu experi perform human peripher blood mononuclear cell pbmcs thp cell monocyt cellular model hek cell genet modifi studi activ tlr tf procoagul activ assess one stage clot time test tf protein express estim western blot human recombin hr ggt protein increas tf procoagul activ protein express pbmcs thp cell ggt induc tf stimul prevent cellular pretreat tlrnf b inhibitor lps rs cli bay hek cell lack tlr confirm tlr essenti ggt induc activ nf b conclus hrggt induc tf express monocyt cytokin like mechan involv activ tlrnf b signal
|
D051197;D013925
|
T129;T116;T192
|
36,293,060
|
influenc differ salt g quadruplex structur form revers human telomer dna sequenc g rich telomer dna play major role stabil chromosom fold plethora differ g quadruplex structur presenc mono dival cation revers human telomer dna sequenc ggg att revhumtel previous shown interest properti exploit chemic sens chemic switch dna nanotechnolog analyz specif g quadruplex structur form revhumtel presenc k na mg ca cation use circular dichroism spectroscopi cds frster reson energi transfer fret base fluoresc lifetim cds abl reveal strand loop orient wherea fret give inform distanc end end also number g quadruplex speci form base combin inform deriv specif g quadruplex structur form revhumtel ie chair type hybrid type g quadruplex structur form presenc k wherea na induc format three differ g quadruplex basket type propel type hybrid type structur presenc mg ca two differ parallel g quadruplex form one propel type structur studi support fundament understand g quadruplex format differ environ ration design g quadruplex base applic sens nanotechnolog
|
D054856
|
T086
|
36,293,059
|
silico structur analysi serin carboxypeptidas nf potenti drug target naegleria fowleri infect naegleria fowleri also known brain eat amoeba free live protozoan resid freshwat bodi pathogen amoeba infect human casual event swim contamin water upon inhal n fowleri invad central nervous system caus primari amoeb meningoenceph pam rapid progress often fatal diseas although pam consid rare reduc case fatal rate compel search pathogen specif protein structur function relationship favor applic target discov new improv drug n fowleri infect herein report comput approach studi structur featur nf serin carboxypeptidas virul relat protein n fowleri infect assess potenti drug target use bioinformat tool silico molecular dock experi find suggest nf ligand bind site suitabl structur base design specif inhibitor studi repres step toward postul reliabl therapeut target treat pam drug specif aim block pathogen prolifer inhibit protein function
|
D020808;D016848
|
T047;T204
|
36,293,058
|
hydrogen sulfid donor key unlock chain nonalcohol fatti liver diseas hydrogen sulfid h emerg third gasotransmitt crucial function divers physiolog function mammal particular h consid indispens prevent develop liver inflamm case excess calor ingest note concentr endogen h usual low make difficult discern precis biolog function therefor exogen deliveri h conduc probe physiolog patholog role gas cellular anim studi review product metabol pathway h vivo type donor current use h releas studi evid h improv effect nonalcohol fatti liver diseas systemat introduc
|
D006862;D065626;D064426
|
T123;T131;T197;T047;T130
|
36,293,057
|
impact exosom releas differ corneal cell type wound heal properti human corneal epitheli cell corneal wound heal involv communic differ cell type constitut three cellular layer cornea epithelium stroma endothelium process ensur part categori extracellular vesicl call exosom present studi isol exosom releas primari cultur human corneal epitheli cell hcec corneal fibroblast hcfs corneal endotheli cell hcenc determin whether wound heal characterist point modifi genet proteom pattern cell type exosom releas three cell type signific acceler wound closur scratch wound hcec vitro compar control without exosom profil activ kinas reveal exosom human corneal cell caus activ signal transduct mediat belong hsp stat catenin gsk p pathway data gene profil analys indic exosom irrespect cellular origin alter restrict subset gene complet differ target cell type hcec hcfs hcenc analysi gene specif differenti regul given cell type microarray data use ingenu pathway analysi ipa softwar reveal mean gene express profil hcec cultur presenc exosom would like promot cell prolifer migrat wherea would reduc differenti compar control cell collect find repres conceptu advanc understand mechan corneal wound repair may ultim open new avenu develop novel therapeut approach improv closur corneal wound
|
D055354;D065306
|
T026;T033;T037
|
36,293,056
|
enhanc antimicrobi activ biocompat bacteri cellulos film via dual synergist action curcumin triangular silver nanopl curcumin triangular silver nanopl tsnp incorpor bacteri cellulos bc film present ideal antimicrobi materi biomed applic afford complet set requir includ broad rang long last potenc superior efficaci antimicrobi activ combin low toxic bc produc komagataeibact medellinensi id strain presenc curcumin product medium tsnp incorpor produc bccurcumin film use ex situ method ppm antimicrobi activ evalu escherichia coli atcc staphylococcus aureus atcc bacteri strain biolog activ natur product assess cytotox assay lung fibroblast vivo use caenorhabd elegan danio rerio model organ deriv film shown excel antimicrobi perform growth inhibit e coli aureus high posit synergist interact bc film curcumin incorpor tsnp shown reduc toxic mrc cell surviv rate shown concentr film extract induc low toxic effect model organ develop combin synergist advanc anti infect function curcumin tsnp incorpor bc high potenti develop applic within clinic set
|
D003474;D000890;D001688;D053768
|
T121;T123;T073;T109;T130
|
36,293,055
|
vivo silico investig anti obes effect lactiplantibacillus plantarum combin chia seed green tea chitosan allevi hyperlipidemia inflamm increas preval obes becom demand issu high incom low incom countri treat obes challeng treatment option mani limit recent diet modif common appli control prevent obes risk studi investig novel therapeut approach use combin potenti probiot sourc prebiot forti eight adult male spragu dawley rat select divid seven group eight rat per group first group fed high fat diet second group negat control five group oral administ probiot lactiplantibacillus plantarum l plantarum potenti prebiot sourc chia seed green tea chitosan either individu combin day collect blood sampl analyz biochem paramet dissect organ includ liver kidney pancrea evalu obes relat injuri observ signific decreas total bodi weight combin approach individu agent moreov treat obes rat combin decreas serum catalas superoxid dismutas liver malondialdehyd level histopatholog examin reveal reduct obes relat injuri liver kidney pancrea dock studi indic potenti role chia seed green tea compon modul obes relat problem therefor suggest daili administr pre probiot combin may reduc obes relat problem
|
D048271;D006949
|
T033;T121;T047;T109
|
36,293,054
|
genet architectur vascular anomali current data futur therapeut perspect correl molecular mechan vascular anomali vas morphogenesi defect vascular system arteri capillari vein lymphat vessel singular complex combin sometim sever impact qualiti life progress made recent year identif key molecular pathway pikaktmtor rasbrafmapkerk gene mutat lead appear vas allow deciph complex genet architectur understand mechan critic correct definit phenotyp classif vas well initi optim therapi develop new target therapi purpos review present synthesi current data relat genet factor involv etiolog vas well possibl direct futur research analyz data literatur relat vas use databas googl scholar pubm medlin omim medgen orphanet clinicaltrialsgov obtain result reveal phenotyp variabl vas correl genet heterogen identif new genet factor molecular mechan interven allow develop modern therapi act target person therapi emphas import geneticist diagnosi treatment vas part multidisciplinari team involv manag vas
|
D054079;D014652
|
T047;T190
|
36,293,053
|
intersect ubiquitin proteasom system oxid stress cardiovascular diseas cardiovascular diseas cvds present major social problem worldwid due high incid mortal rate mani pathophysiolog mechan involv cvds oxid stress play vital mediat role mechan ubiquitin proteasom system up main machineri respons degrad cytosol protein repair system interact mechan regul endoplasm reticulum homeostasi recent evid also point role up dysfunct develop cvds up associ oxid stress regul reduct oxid homeostasi howev mechan under up mediat oxid stress contribut cvds unclear especi role interact differ diseas stage review highlight recent research progress role up oxid stress individu combin cvds focus pathophysiolog key cvds includ atherosclerosi ischemia reperfus injuri cardiomyopathi heart failur synthesi provid new insight continu research up oxid stress interact turn suggest novel target treatment prevent cvds
|
D025801;D002318
|
T123;T047;T116
|
36,293,052
|
intrauterin inject hcg improv ivf outcom systemat review meta analysi various intervent propos improv embryo implant ivf among intrauterin inject human chorion gonadotropin seem promis result consequ conduct review meta analysi assess ivf outcom compar coupl underw intrauterin hcg inject transfer versus underw embryo transfer intrauterin inject placebo without addit intervent primari outcom clinic pregnanc rate secondari outcom implant rate miscarriag rate live birth rate meta analysi conduct use random effect model bias within studi detect use cochran risk bias tool ectop pregnanc stillbirth also assess clinic pregnanc rr ci p lt implant rate rr ci p signific higher women underw hcg inject control group signific effect persist women underw cleavag stage embryo transfer signific differ group observ secondari outcom conclus systemat review meta analysi demonstr intrauterin inject hcg could valuabl approach women undergo cleavag stage embryo transfer given lack data live birth rate caution exercis interpret data
|
D004624;D006063
|
T061;T121;T116;T125
|
36,293,051
|
anti ptk monoclon antibodi exhibit anti tumor activ cellular level mous xenograft model esophag squamous cell carcinoma ptk catalyt defect receptor protein tyrosin kinas upregul various cancer includ esophag squamous cell carcinoma escc previous studi observ posit correl ptk express level tumorigen various escc cell line xenograft mice escc kyse cell studi analyz effect anti ptk monoclon antibodi mab tumorigen activ kyse cell mous xenograft model ptk mab mab bind high affin extracellular domain ptk ptk mab signific reduc three dimension cell prolifer adhes wound heal migrat ptk mab also reduc chemotact invas decreas mmp secret ptk mab decreas actin cytoskeleton level cortic region kyse cell ptk mab reduc phosphoryl erk src fak mous xenograft model escc use kyse cell ptk mab reduc tumor growth term volum weight number ki posit cell result demonstr ptk mab inhibit tumorigen escc cellular level vivo block function ptk consid anticanc activ ptk mab propos ptk mab use effect treatment strategi ptk posit malign escc
|
D000077277;D004938;D002294
|
T191
|
36,293,050
|
acp ada boost method data augment improv predict anticanc peptid cancer second lead caus death worldwid therapeut peptid target destroy cancer cell receiv great deal interest recent year tradit wet experi expens ineffici identifi novel anticanc peptid therefor develop effect comput approach essenti recogn acp candid experiment method use studi propos ada boost algorithm base learner random forest call acp ada integr binari profil featur amino acid index amino acid composit dimension featur space vector repres peptid train sampl featur space augment increas sampl size improv perform model case insuffici sampl furthermor use five fold cross valid find model paramet cross valid result show acp ada outperform exist method featur combin data augment term perform metric specif acp ada record averag accuraci mathew correl coeffici dataset acp dataset acp consequ use tool drug develop biomed research
|
D019295;D009369
|
T191;T091
|
36,293,049
|
pcsk affect astrocyt cholesterol metabol reduc neuron cholesterol suppli vitro potenti implic alzheim diseas proprotein convertas subtilisinkexin type pcsk involv alzheim diseas ad poor investig evalu vitro pcsk modul astrocyt cholesterol metabol neuron cholesterol suppli fundament neuron function moreov investig pcsk neurotox effect human astrocytoma cell pcsk reduc cholesterol content p lt greater effect presenc beta amyloid peptid p lt pcsk increas cholesterol synthesi reduc uptak apo hdl deriv cholesterol p lt well ldl receptor ldlr apo receptor apoer express respect p lt pcsk modul abca abcg cholesterol efflux abca level membran cholesterol convers abca express activ well membran cholesterol reduc p lt human neuron cell pcsk reduc apo hdl deriv cholesterol uptak p lt ldlrapoer express p lt reduc cholesterol intern occur also pcsk overexpress neuron expos astrocyt condit medium p lt pcsk reduc neuron cholesterol content overal p lt increas induc neurotox p lt data reveal interf effect pcsk cooper brain cholesterol metabol lead neuron cholesterol reduct potenti deleteri effect pcsk also exert neurotox effect thus repres potenti pharmacolog target ad
|
D000071449;D000544
|
T047;T126;T116;T048
|
36,293,048
|
temperatur influenc sleep sleep fundament evolutionarili conserv plastic behavior regul circadian homeostat mechan well genet factor environment factor light humid temperatur among environment cue temperatur play import role regul sleep review present overview thermorecept anim neural circuit link process sleep understand influenc temperatur sleep provid insight basic physiolog process requir surviv guid strategi manag sleep disord
|
D002940;D012890
|
T033;T040
|
36,293,047
|
boron cluster enhanc rnase h activ smart strategi gene silenc antisens oligonucleotid boron cluster conjug antisens oligonucleotid b aso alreadi develop therapeut agent two face name potenti antisens inhibitor gene express boron carrier boron neutron captur therapi bnct previous observ high antisens activ b aso target epiderm growth factor receptor egfr could ration assign posit boron cluster unit dicarba closo dodecaboran iron dicarbollid fesan dodecabor aso chain structur charg understand observ perform systemat studi effici rnase h seri b aso model result kinet analysi show pyrimidin enrich b aso oligom activ rnase h effici non modifi aso presenc singl fesan unit specif posit b aso increas kinet enzymat hydrolysi complementari rna fold compar unmodifi duplex asorna moreov rate rna hydrolysi enhanc increas negat charg boron cluster b aso chain conclus smart strategi use aso conjug boron cluster mileston develop effici antisens therapeut nucleic acid inhibitor gene express
|
D016376;D001895
|
T123;T196;T130;T114
|
36,293,046
|
ectodysplasin defici lead osteopetrosi like chang bone skull associ diminish osteoclast activ pathogen variant gene eda caus x link hypohidrot ectoderm dysplasia xlhed character structur abnorm lack ectoderm appendag sign dysplasia restrict deriv ectoderm layer mesoderm abnorm craniofaci dysmorph also frequent observ suggest close reciproc interact ectoderm mesoderm howev causal link remain unsubstanti investig function impact defect ectodysplasin eda signal postnat bone homeostasi eda defici tabbi mice interest eda detect wild type mous calvaria throughout postnat lifetim calvaria bone line osterix osx osteoblast stain posit eda osteoclast reveal eda receptor edar posit moreov adult eda defici calvari bone show osteopetrosi like chang signific diminish marrow space maintain adulthood concomit osteopetrosi like chang tabbi calvari bone tabbi bone marrow deriv osteoclast far less osteoclast activ associ co enzym includ cathepsin k mmp trap tcirg v type proton atpas subunit compar wild type calvaria vivo osteoclast vitro indic eda defici may affect activ osteoclast final confirm nuclear nfatc posit osteoclast strong diminish matur osteoclast differenti csf rankl tabbi model fc eda treatment tabbi deriv osteoclast signific increas nuclear transloc nfatc furthermor identifi enhanc nfatc nf b transcript activ follow fc eda treatment vitro use luciferas assay overal result indic diminish express osteoclast activ associ co enzym may lead disturb bone homeostasi tabbi calvaria postnat
|
D010022;D053358
|
T047
|
36,293,045
|
profil substrat specif sumo proteas ulp yess pssc system advanc conserv mechan substrat cleavag sumo modif vital post translat regul process eukaryot sumo proteas respons matur sumo precursor deconjug sumo protein modifi protein accur cleav behind c termin gli gli motif promot understand high specif sumo proteas sumo protein well clarifi whether conserv gli gli motif strict requir process sumo precursor systemat profil specif cerevisia sumo proteas ulp smt p pp gli glyala posit use yess pssc system result demonstr ulp abl cleav gli gli motif mutat substrat indic diglycin motif strict requir ulp cleavag structur model analysi indic special taper activ pocket ulp confer select small residu p p posit smt gli ala ser cys smooth deliv scissil bond activ site cleavag meanwhil p posit ala smt found play vital role maintain ulp precis cleavag gli gli motif replac ala gli posit could expand ulp inclus p p posit residu smt studi advanc tradit knowledg sumo protein may provid potenti direct drug discoveri abnorm sumoyl relat diseas
|
D012441;D029701
|
T004;T116
|
36,293,044
|
iron sepiolit high perform magnetorheolog polish fluid reduc sediment sediment stabl magnetorheolog mr polish slurri basi ferrofluid iron particl al clay nanofil form sepiolit intend mr polish design prepar polish effici verifi ad clay substanti improv sediment stabil slurri decreas sediment rate quarter origin valu mg otherwis maintain good abras properti magnetis curv measur prove design slurri soft magnet materi hysteresi suitabl mr polish confirm magnetorheolog name quadrat increas yield stress due effect appli magnet field ka effici mr polish process test flat sampl inject mould polyamid verifi surfac roughnessd textur measur result new composit mr polish slurri exhibit long term stabl system wide applic window mr polish process
|
D007501;D009757
|
T123;T121;T109;T196;T122
|
36,293,043
|
tcmyb r myb transcript factor posit regul pyrethrin biosynthesi tanacetum cinerariifolium pyrethrin mixtur terpen insecticid properti accumul aboveground part pyrethrum tanacetum cinerariifolium numer studi publish posit role myb transcript factor tfs terpenoid biosynthesi howev role myb tfs pyrethrin biosynthesi remain unknown report isol character cinerariifolium amp nbsp myb gene encod r myb protein tcmyb contain larg number hormon respons element promot express tcmyb gene show downward trend develop stage flower leav induc methyl jasmon meja salicyl acid sa abscis acid aba transient overexpress tcmyb enhanc express key enzym encod gene tcchs tcglip increas content pyrethrin contrast transient silenc tcmyb decreas pyrethrin content downregul tcchs tcglip express analysi indic tcmyb direct bind cis element pro tcchs pro tcglip activ express thus regul pyrethrin biosynthesi togeth result highlight potenti applic tcmyb improv cinerariifolium germplasm provid insight pyrethrin biosynthesi regul network
|
D011723;D011722
|
T131;T002;T109
|
36,293,042
|
emerg role extracellular vesicl autophagi machineri nash futur horizon nash manag non alcohol fatti liver diseas nafld consid frequent chronic hepat diseas general popul first caus liver transplant us nafld patient subsequ develop non alcohol steatohepat nash character aberr hepatocellular inflamm without presenc fibrosi lack specif biomark therapeut strategi make non alcohol steatohepat nash manag difficult task clinician extracellular vesicl ev constitut heterogen popul vesicl produc inward outward plasma membran bud emerg connect autophagi ev product via unconvent non degrad procedur alter amount secret ev cargo carri also involv diseas progress develop nash autophagi constitut multistep lysosom degrad pathway reassur cell homeostasi surviv stress condit oxygen energi depriv prevent cellular damag elimin defect protein nn function intracellular organell time reassur optim condit cell via differ mechan includ remov cargo via secret ev similar autophagi machineri also associ pathogenet mechan nafld signific implic progress diseas develop nash review shed light interplay autophagi ev nash emerg connect ev product autophagi pathway possibl manipul develop futur therapeut strategi nash
|
D065626;D000067128
|
T026;T047
|
36,293,041
|
peroxisom prolifer fppex involv develop pathogen fusarium pseudograminearum fusarium crown rot fcr wheat import soil born diseas present worsen trend year year pose signific threat wheat product fusarium pseudograminearum cv b report domin pathogen fcr china peroxisom singl membran organell eukaryot involv mani import biochem metabol process includ fatti acid oxid pex import protein peroxisom prolifer less known fungus f pseudograminearum function fppexa fppexb fppexc f pseudograminearum studi use revers genet result show fppexa fppexb involv regul veget growth asexu reproduct delet fppexa fppexb cell wall integr impair cellular metabol process includ activ oxygen metabol fatti acid oxid signific block product abil deoxynivalenol decreas addit delet gene fppexa fppexb reveal strong decreas express level peroxisom prolifer associ gene synthesi relat gene howev delet fppexc signific affect metabol process delet three protein code gene result reduc pathogen f pseudograminearum summari fppexa fppexb play crucial role growth develop asexu reproduct pathogen activ oxygen accumul fatti acid util f pseudograminearum
|
D005670
|
T004
|
36,293,040
|
interferon beta versus combin interferon beta oligodendrocyt specif fgfr delet experiment autoimmun encephalomyel recombin beta interferon ifn use first line therapi patient relaps multipl sclerosi ms chronic inflammatori neurodegen diseas cns ifn ab moder effect prevent relaps slow diseas progress fibroblast growth factor fgfs fgf receptor fgfrs known play key role patholog ms model eae investig effect short term treatment sc ifn versus combin applic sc ifn oligodendrocyt specif delet fgfr fgfrind mice mog induc eae ifn mgkg appli sc day pi eae control fgfrind mice fgfr signal protein associ inflammationdegener mseae analyz western blot spinal cord fgfr oli neu oligodendrocyt inhibit pd treat ifn ngml applic ifn day result less symptom peak diseas day compar control applic ifn fgfrind mice result less symptom primarili chronic phase eae fgfrind mice treat ifn show increas express perk bdnf oli neu oligodendrocyt treatment pd ifn also show increas express perk bdnftrkb data suggest benefici effect chronic phase eae signal molecul associ erk bdnf express caus modul fgfr interferon beta fgfr may potenti target therapi ms
|
D004681;D019636;D009103
|
T047;T050
|
36,293,039
|
sensit determin trace nitrophenol ambient environ use glassi carbon electrod modifi formamid convert nitrogen dope carbon materi sens trace amount nitrophenol np harm substanc organ even small quantiti great import present studi includ sensit select electrochem sensor detect np natur water sampl use formamid convert nitrogen carbon materi shorten f nc new materi electrod modif structur morpholog f nc set apart sem tem xrd xps ftir raman electrochem perform f nc set apart cv ei cc studi electrochem behaviour np glassi carbon electrod modifi f nc pyrolysi treatment denot f ncgce f ncgce h solut f ncgce appar electrocatalyt activ reduc np optim condit reduct peak current np vari linear concentr rang mm detect limit obtain mm sn addit electrochem sensor high select stabil quit good prepar applic sensor detect np water sampl produc satisfactori result provid new method simpl sensit quantit detect np
|
D002244;D009584
|
T121;T196;T123
|
36,293,038
|
comprehens gene co express network analysi reveal role ghwrki respond drought salt stress abiot stress drought salin stress serious inhibit growth develop plant therefor vital understand drought salin resist mechan enabl cotton provid product drought salt condit studi identifi differenti express gene deg comprehens analysi transcriptom data relat peg induc osmot salt stress cotton perform weight gene co express network analysi wgcna identifi four co express modul peg treatment five co express modul salin stress includ predict transcript factor tfs modul respect correspond whole genom duplic wgd event main contribut expans tfs kyoto encyclopedia gene genom kegg gene ontolog go analys reveal differ modul associ stress resist includ regul macromolecul metabol process peptidas activ transport activ lipid metabol process respons stimulus quantit rt pcr analysi use confirm express level hub tfs peg salin treatment found hub gene ghwrki could alter salt peg induc drought resist cotton virus induc gene silenc vig method result provid preliminari framework investig cotton respons salt drought stress signific breed salt drought toler cotton varieti
|
D055864;D018506
|
T045;T070
|
36,293,037
|
associ insert delet polymorph angiotensin convert enzym gene treatment respons antipsychot medic studi antipsychot nave first episod psychosi patient nonadher chronic psychosi patient investig whether function insertiondelet id polymorph angiotensin convert enzym ace influenc antipsychot treatment baselin week treatment various antipsychot medic assess patient posit negat syndrom scale panss score panss factor metabol syndrom relat paramet fast plasma lipid glucos level bodi mass index total antipsychot nave first episod psychosi patient nonadher chronic psychosi individu male femal genotyp polymeras chain reaction analysi ace id polymorph signific associ chang panss psychopatholog p lt compar ace ii homozyg male ace dd homozyg ace id heterozyg male manifest signific greater decreas panss posit score panss excit factor panss cognit factor ace dd homozyg femal manifest higher decreas panss depress factor compar ace ii homozyg ace id heterozyg femal polymorph effect size estim moder strong contribut panss psychopatholog rang lowest contribut observ panss posit score chang highest panss depress factor chang result indic ace id polymorph statist signific weak gender specif impact psychopatholog data show associ ace id polymorph metabol syndrom relat paramet
|
D014150;D024821;D011618
|
T121;T039;T048;T047
|
36,293,036
|
anthocyanin biosynthesi associ natur variat autumn leaf color quercus aliena access quercus aliena econom import tree speci one domin nativ oak speci china although leav typic turn yellow autumn observ natur variant red leav import understand mechan involv leaf color variat speci therefor compar q aliena tree yellow leav three variant red leav differ stage senesc order determin caus natur variat found accumul anthocyanin cyanidin glucosid cyanidin sambubiglycosid signific effect leaf color gene express analysi show upregul almost gene encod enzym involv anthocyanin synthesi red leav variant earli main discolor stage senesc find consist accumul anthocyanin red variant furthermor variant show signific higher express transcript factor associ anthocyanin synthesi encod gene qamyb qamyb find provid new insight physiolog molecular mechan involv autumn leaf color q aliena well provid genet resourc develop cultiv valuabl ornament variant speci
|
D000872;D029963
|
T121;T002;T109
|
36,293,035
|
fold mechan aggreg propens kh domain fmrp rq patholog variant k homolog kh domain small structur conserv domain found protein differ origin character central conserv core gxxg motif loop two helic kh core eukaryot khi type addit element decor core c terminus protein contain kh domain perform differ function sever diseas associ mutat domain includ fragil x mental retard protein fmrp fmrp rna bind protein crucial control rna metabol whose lack mutat lead fragil x syndrom fxs among missens mutat rq substitut kh degener domain lack classic gxxg motif combin equilibrium kinet experi present character fold mechan kh domain fmrp wild type rq variant show case fold mechan impli accumul pathway transient intermedi moreov exploit batteri biophys techniqu show kh domain propens form amyloid like aggreg mild condit vitro rq mutat lead general destabil protein increas fibrillogenesi propens
|
D051860;D005600
|
T123;T047;T116
|
36,293,034
|
detect immun wt smad pl epcam cancer cell malign pleural effus malign pleural effus mpe provid liquid tumor microenviron model includ cancer cell immun cell howev characterist tumor antigen specif cd cell investig detail analyz mpe sampl taken patient pancreat cancer receiv dendrit cell vaccin target wilm tumor wt antigen diseas cours two point mpe st nd two month mpe st epitheli cell adhes molecul epcam cancer cell pd l cell immunoglobulin mucin tim pd tim posit cd cell cd cd cd tim macrophag increas mpe st mpe nd ratio wt specif cytotox lymphocyt wt ctls mpe cd cell ifn secret wt ctls reduc diseas progress coincident fraction central memori cm wt ctls decreas hand cd cell respons smad pl homogen express epcam cancer cell detect use vitro expans hla restrict svcvnlyh neoantigen furthermor cd cell respons smad pl diminish follow remark decreas number cd cm mpe sampl conclus cd cell respond wt smad pl neoantigen express epcam pancreat cancer cell detect mpe tumor antigen specif immun respons would provid novel insight mpe microenviron
|
D016066;D010190;D014612
|
T121;T129;T116;T191;T047
|
36,293,033
|
select recoveri palladium ii metallurg wastewat use thiadiazol base chloromethyl polystyren modifi adsorb select adsorpt palladium metallurg wastewat contain pt iv rh iii ca cu fe ni pb v ti tremend econom environment benefit paper novel thiadiazol base chloromethyl polystyren modifi adsorb viz bis polystyren thiadiazol ps dmtd synthes use chloromethyl polystyren backbon experiment result show ps dmtd select separ pd ii metallurg wastewat one step adsorpt process calcul satur adsorpt capac ps dmtd pd ii mgg c separ factor pd ii n n pt iv rh iii ca cu fe ni pb v ti higher ft ir xps singl crystal x ray diffract show adsorpt pd ii ps dmtd primarili coordin mechan densiti function theori dft calcul reveal base metal ion could coordin ps dmtd pt iv could adsorb ps dmtd due strong chlorophil furthermor rh iii exist polyhydr inhibit rh iii diffus toward posit charg absorpt site ps dmtd result highlight ps dmtd broad applic prospect recoveri pd ii metallurg wastewat
|
D010165;D013830
|
T196;T109
|
36,293,032
|
cytochrom p bscypa bscypa confer metabol resist al herbicid beckmannia syzigachn beckmannia syzigachn noxious grassi weed infest wheat field china previous identifi mesosulfuron methyl resist b syzigachn popul r sd confer non target resist cytochrom p mix function oxidas ps base metabol rna sequenc real time pcr qrt pcr use discov potenti ps resist relat gene five cytochrom ps cypa cypb cypd cypa cypa found high express r plant studi cypa cypa clone b syzigachn transfer arabidopsi thaliana test sensit arabidopsi without ps gene mesosulfuron methyl acetolact synthas al inhibit herbicid transgen arabidopsi overexpress cypa becam resist sulfonylurea herbicid mesosulfuron methyl show resist pyroxsulam imazethapyr flucarbazon bispyribac sodium notabl overexpress cypa show resist pyroxsulam bispyribac sodium mesosulfuron methyl imazethapyr flucarbazon result indic b syzigachn transgen arabidopsi display differ cross resist pattern al inhibit herbicid subcellular local reveal cypa cypa protein locat endoplasm reticulum furthermor result clear indic cypa mediat mesosulfuron methyl resist b syzigachn cypa may involv b syzigachn cross resist pyroxsulam bispyribac sodium
|
D000095;D006540;D017360
|
T131;T126;T116;T002
|
36,293,031
|
rlpredictiom machin learn deriv method high throughput predict plant receptor like protein reveal novel class transmembran receptor cell surfac receptor play essenti role perceiv process extern intern signal cell surfac plant anim receptor like protein kinas rlk receptor like protein rlps two major class protein membran receptor configur play crucial role plant develop diseas defens although rlps rlks share similar singl pass transmembran configur rlps harbor short diverg c termin region instead conserv kinas domain rlks rlp receptor structur design preclud sequenc comparison algorithm use high throughput predict rlp famili plant genom extens perform rlk superfamili predict develop rlpredictiom implement machin learn model combin bayesian infer capabl predict rlp subfamili plant genom ml model simultan train use six type featur along three stage distinguish rlps non rlps nrlps rlps rlks classifi new subfamili rlps plant ml model achiev high accuraci precis sensit specif predict rlps relat high probabl rang predict method assess three dataset two contain leucin rich repeat lrr rlps arabidopsi rice last one consist complet set previous describ arabidopsi rlps valid test known rlps correct predict via rlpredictiom addit predict previous character rlps rlpredictiom uncov new rlp subfamili arabidopsi genom includ probabl lipid transfer plt rlp plastocyanin like rlp ring finger rlp glycosyl hydrolas rlp glycerophosphoryldiest phosphodiesteras gdpd gdpdl rlp subfamili yet character compar arabidopsi gdpdl rlk molecular evolut studi confirm ectodomain gdpdl rlps might undergon purifi select predomin synonym substitut express analys reveal predict gdpgl rlps display basal express level respond development biotic signal result biolog assay indic subfamili member maintain function domain evolut may play relev role develop plant defens therefor rlpredictiom provid framework genom wide survey rlp superfamili foundat ration function studi surfac receptor relationship differ biolog process
|
D010940;D017360
|
T116;T002
|
36,293,030
|
hyaluron acid scaffold loco region therapi nervous system relat disord hyaluron acid ha glycosaminoglycan made disaccharid unit contain n acetyl glucosamin glucuron acid molecular mass reach mda physiolog properti depend polymer properti polyelectrolyt featur viscous natur ha ubiquit compound found almost biolog tissu fluid far ha grade produc biotechnolog process human organ major compon extracellular matrix ecm brain tissu synovi fluid vitreous humor cartilag skin inde ha capabl form hydrogel polym crosslink network hygroscop base consider propos overview ha base scaffold develop brain cancer treatment central peripher nervous system discuss relev identifi success develop system
|
D006820;D000117
|
T123;T122;T121;T109
|
36,293,029
|
influenc exogen jasmon acid biosynthesi steroid triterpenoid calendula officinali plant hairi root cultur interplay steroid triterpenoid compound share biosynthet pathway exert distinct function import part defens strategi plant includ metabol modif trigger stress hormon jasmon acid two experiment model calendula officinali hairi root cultur greenhous cultiv plant pot plant appli investig effect exogen appli jasmon acid biosynthesi accumul steroid triterpenoid character target gc ms gas chromatographi mass spectroscopi metabolom profil jasmon acid elicit strong increas triterpenoid saponin product hairi root cultur fold releas medium fold wherea effect observ pot plant less remark two fold enhanc saponin biosynthesi singl foliar applic model increas triterpenoid biosynthesi coupl hamper biomass format modifi sterol content involv stigmasterol sitosterol ratio proport ester glycosid conjug studi reveal various organ plant react differ jasmon acid elicit hairi root cultur use vitro model track metabol chang enhanc glycosyl triterpenoid sterol seem import strategi plant defens respons
|
D020838;D014315;D012503
|
T002;T109
|
36,293,028
|
develop bi gold compound bgca target mitochondria elimin cancer cell reactiv oxygen speci ros homeostasi mitochondri metabol critic surviv cancer cell includ cancer stem cell cscs often caus drug resist cancer relaps auranofin mono gold anti rheumat drug repurpos anticanc agent work induct ros increas mitochondri dysfunct hypothet increas auranofin posit charg via incorpor gold atom enhanc mitochondria target capac could enhanc anti cancer efficaci henc work mono gold bi gold compound design evalu test hypothesi result show bi gold compound general suppress cancer cell prolifer better mono gold counterpart potent compound bgca substanti inhibit antioxid enzym trxr increas cellular ros bgca induc cell apoptosi could revers antioxid agent vitamin c impli ros induc trxr inhibit might decis caus cell death expect signific proport bgca accumul within mitochondria like contribut mitochondri dysfunct confirm measur oxygen consumpt rate mitochondri membran potenti atp product moreov bgca inhibit coloni format reduc stem like side popul sp cell final compound effect suppress tumor growth panc xenograft studi show mitochondri disturb may gold base compound major lethal factor erad cancer cell provid new approach develop potent gold base anti cancer drug increas mitochondria target capac
|
D018501;D009369
|
T121;T191
|
36,293,027
|
anti allerg activ fucoidan enhanc coexist quercetin recent year incid type hypersensit includ hay fever increas year year japan previous studi use mice show oral intraperiton administr fucoidan extract seawe saccharina japonica suppress type hypersensit secret galectin high affin ige blood howev amount seawe requir achiev activ quit high g dri weight per person per day therefor purpos studi search food ingredi veget enhanc type hypersensit suppress effect consum togeth fucoidan result enhanc effect observ extract welsh onion onion among veget compar polyphenol veget show activ flavonol quercetin kaempferol found candid quercetin kaempferol g oral administ time even amount fucoidan alon show anti allerg activ anti allerg effect observ interest flavonol combin administ simultan half amount flavonol g fucoidan amount remain similar effect observ flavonol g administ alon simultan intak fucoidan veget contain high content quercetin kaempferol may reduc fucoidan intak maintain allergi suppress effect suggest import food combin
|
D018926;D006969;D000074385
|
T121;T046;T168
|
36,293,026
|
acid shift optimum ph bovin serum amin oxidas upon immobil onto nanostructur ferric tannat protein nanoparticl hybrid repres entiti character emerg biolog properti signific differ parent compon herein bovin serum amin oxidas ie bsao immobil onto magnet nanomateri constitut surfac activ maghemit nanoparticl ie samn core surfac modifi tannic acid ie ta shell produc biolog activ ternari hybrid ie samn ta bsao comparison nativ enzym secondari structur immobil bsao respond ph variat sensit result shift optimum activ ph convers nativ enzym structur influenc ph activ affect ph ie correspond best perform samn ta bsao thus extens nmr studi dedic structur function relationship nativ bsao confirm low activ ph ascrib minim structur modif detect circular dichroism generat cytotox product aldehyd h catalyt activ samn ta bsao polyamin oxid envisag smart nanotherapi tumor cell present studi support protein nanoparticl conjug key modul biolog function
|
D049329;D006631
|
T116;T126;T073
|
36,293,025
|
proteom profil plant pathogen interact leaf epidermi plant epidermi first line plant defens pathogen invas like contain import regulatori protein relat plant pathogen interact studi aim identifi candid regulatori protein express plant epidermi perform compar proteom studi identifi rapid local express protein leaf epidermi inocul fungal phytopathogen conidia solut drop onto arabidopsi leaf surfac collect epiderm tissu inocul mock treat leav hpi label free quantif method show express arabidopsi protein relat defens signal bak mkk receptor like protein kinas transcript factor stomat function rapid induc epiderm tissu inocul leav contrast differenti regul fugal inocul whole leav find clear indic epiderm proteom monitor local express protein inocul area plant tissu also identifi fungal protein includ effector like protein specif express arabidopsi epidermi new find suggest epiderm proteom use understand local express plant fungal protein relat interact
|
D017360;D029681
|
T116;T002
|
36,293,024
|
singl cell transcriptom profil inherit retin degener reveal distinct metabol pathway rod cone photoreceptor cellular mechan under hereditari photoreceptor degener still poor understood aim studi systemat map transcript chang occur degener mous retina singl cell level end employ singl cell rna sequenc scrna seq retin degener rd mice profil impact diseas mutat divers retin cell type earli post natal develop transcriptom data allow annot individu cell group distinct cluster character cluster specif metabol biolog chang individu cell type result highlight ca signal relev hereditari photoreceptor degener although metabol reprogram retina known warburg effect document metabol chang notic rd mice metabol chang rd mutat like regul mitogen activ protein kinas mapk pathway combin singl cell transcriptom immunofluoresc stain studi reveal cell type specif chang gene express well interplay ca induc cell death metabol pathway
|
D012162
|
T046
|
36,293,023
|
biodegrad biodegrad polym mesophil aerob environ find altern diminish plastic pollut becom one main challeng modern life altern gain potenti shift toward circular sustain relationship plastic biodegrad polym deriv bio fossil base sourc emerg one feasibl altern overcom inconveni associ use dispos non biodegrad polym biodegrad process depend environ factor microorgan associ enzym polym properti result plethora paramet creat complex process wherebi biodegrad time rate vari immens review aim provid background comprehens systemat critic overview complex process special focus mesophil rang activ toward depolymer extracellular enzym biofilm effect dynam degrad process co evolut evalu extent biodegrad metabol pathway discuss remark perspect potenti futur research provid focus current knowledg gap goal minim persist plastic across environ innov approach addit specif compound trigger depolymer particular condit biostimul bioaugment addit natur andor modifi enzym state art method need faster develop furthermor method must connect standard techniqu fulli track biodegrad process transdisciplinari research within area polym chemistryprocess microbiologybiochemistri need
|
D002245;D063566
|
T123;T197;T073
|
36,293,022
|
temperatur rise insid shear band simpl model glass one key factor hamper applic metal glass structur compon local deform narrow band ten one hundr nanomet thick call shear band process occur insid shear band central import question whether catastroph failur materi unavoid circumv least delay via molecular dynam simul studi address one process name local temperatur rise due viscous heat generat major contribut energi dissip trace back plastic work perform shear stress steadi deform zone largest strain contribut process coincid high temperatur domain hottest spot insid sampl magnitud temperatur rise reach percent sampl glass transit temperatur consequ observ discuss context current research field
|
D005898;D056004
|
T066;T073;T044
|
36,293,021
|
enhanc succin oxid mitochondri complex ii reactiv oxygen speci generat human prostat cancer transform prostat epitheli cell prostat cancer pca character transit citrat secret citrat oxid one would anticip enhanc mitochondri complex ci respiratori flux molecular mechan transform attribut declin mitochondri zinc concentr uniqu metabol properti pca cell becom hot research area sever public provid indirect evid base investig use pre clinic model establish cell line fix frozen tissu bank sampl howev confirmatori respiratori analysi fresh human tissu hamper multipl difficulti thus mitochondri respiratori assess fresh procur human pca tissu publish question object document relat mitochondri ci complex ii cii converg electron flow q junction identifi electron transport system et alter fresh pca tissu result document cii succin quinon oxidoreductas sqr domin succin oxid flux model fresh non malign prostat tissu enhanc malign tissu ci nadh ubiquinon oxidoreductas activ impair rather predomin high grade malign fresh prostat tissu given novel find succin cii promis target treat prevent pca
|
D019802;D011471
|
T121;T191;T109
|
36,293,020
|
role endotheli stat cerebrovascular function protect ischem brain injuri stat play protect role ischem brain injuri howev clear brain cell type mediat effect mechan test hypothesi endotheli stat contribut protect cerebr ischemia preserv cerebrovascular endotheli function blood brain barrier bbb integr object studi determin role stat cerebrovascular endotheli cell ec surviv function role tissu outcom cerebr ischemia found primari mous brain microvascular ec stat constitut activ phosphoryl reduc oxygen glucos depriv ogd recov oxygen stat inhibit use two mechanist differ pharmacolog inhibitor increas ec injuri ogd sub lethal inhibit stat caus endotheli dysfunct demonstr reduc nitric oxid releas respons acetylcholin reduc barrier function endotheli monolay final mice reduc endotheli stat tie cre stat floxwt sustain larger brain infarct middl cerebr arteri occlus mcao compar wild type wt litterm conclud stat vital maintain cerebrovascular integr play role ec surviv function protect cerebr ischemia endotheli stat may serv potenti target prevent endotheli dysfunct stroke
|
D002545;D001930
|
T047;T046;T037
|
36,293,019
|
combin hybrid evalu high lysin rice nutrit physicochem qualiti field perform rice major food crop provid necessari energi nutrit human livestock howev nutrit valu affect lysin use point mutat previous obtain ak aspartokinas dhdps dihydrodipicolin synthas gene insensit lysin feedback inhibit construct transgen line ak dhdps show increas lysin synthesi well ri show decreas lysin degrad inhibit rice lysin ketoglutar reductasesaccharopin dehydrogenas lkrsdh activ studi transgen line hybrid evalu lysin content matur seed pyramid line prd pra increas fold respect compar wild type three gene pyramid line prda moder lysin content total lysin total free lysin total protein content prd pra also increas obvious impact physic chemic qualiti seed appear main agronom trait meanwhil compar analysi polygen polymer line gr contain bacteri ak lysc dhdps dapa gene reveal differ way bacteri endogen rice ak dhdps regul lysin biosynthesi result provid refer evalu commerci high lysin transgen rice
|
D012275;D001222
|
T168;T126;T116;T002
|
36,293,018
|
carrot dcalfin dcalfin transcript factor boost carotenoid level particip differenti salt stress toler express arabidopsi thaliana actinidia deliciosa alfin like transcript factor al involv sever physiolog process seed germin root develop abiot stress respons plant carrot daucus carota express dcpsi gene encod phytoen synthas requir carotenoid biosynthesi induc salt abscis acid aba treatment interest dcpsi promot contain multipl alfin respons element silico analysi identifi two putat gene molecular characterist al dcal dcal carrot transcriptom gene encod nuclear protein transactiv report gene bind carrot dcpsi promot yeast express gene induc carrot salt stress especi dcal also respond aba treatment transgen homozyg arabidopsi thaliana line stabli express dcal dcal show higher surviv rate respect control plant chronic salt stress note dcal line present better perform salt treatment correl express level dcal atpsi atdxr increas carotenoid chlorophyl content likewis dcal transgen kiwi actinidia deliciosa line show increas carotenoid chlorophyl content higher surviv rate compar control plant chronic salt treatment therefor dcal dcal encod function transcript factor ectop express dcal provid increas toler salin arabidopsi kiwi plant
|
D017360;D018552;D029042
|
T168;T002
|
36,293,017
|
pain manag rehabilit central sensit temporomandibular disord comprehens review temporomandibular disord tmd group musculoskelet diseas affect masticatori muscl temporomandibular joint tmj context chronic tmd could consid condit chronic primari orofaci pain present myofasci tmd pain tmj arthralgia context myogen tmd may present overlap featur disord fibromyalgia primari headach character chronic primari pain relat dysfunct central nervous system cns probabl central sensit phenomenon could defin amplifi respons cns sensori stimuli peripher nocicept character hyperexcit dorsal horn neuron spinal cord ascend spinothalam tract main object manag tmd patient decreas pain increas tmj function reduc reflex masticatori muscl spasmpain first line treatment physic therapi pharmacolog drug occlus splint laser therapi extracorpor shockwav therapi transcutan electr nerv stimul oxygen ozon therapi although therapeut approach shown posit impact central sensit tmd pain still agreement topic scientif literatur thus comprehens review aim evalu evid pain manag rehabilit central sensit tmd patient
|
D013705;D009209;D059350;D010126
|
T184;T047;T103
|
36,293,016
|
integr bioinformat investig exosc hepatocellular carcinoma follow preliminari valid exosc cell prolifer exosom complex exosc multiprotein complex origin discov machineri rna degrad interest recent studi report exosc famili member exosc associ various human diseas includ cancer interest investig whether exosc relat process hepatocellular carcinoma hcc studi multipl public databas experiment valid util system investig role exosc especi exosc hcc worth consid mrna protein level mani exosc elev hcc although differ result differ databas analys express exosc could predict hcc extent evidenc posit correl elev exosc alpha fetoprotein afp level well high accuraci shown receiv oper characterist curv analysi addit higher mrna express specif exosc signific relat clinic cancer stage shorter overal surviv diseas free surviv hcc patient moder mutat rate exosc also observ hcc furthermor gene function enrich analysi indic exosc main involv metabol rna moreov reveal express exosc remark relat immun cell infiltr final exosc upregul hcc tissu cell line promot cell growth prolifer via activ signal transduc activ transcript stat bioinformat analys follow verif situ vitro provid direct function under mechan exosc hcc
|
D006528;D008113
|
T191
|
36,293,015
|
role omega fatti acid non photic zeitgeb circadian clock synchron omega fatti acid fas well known action immuneinflammatori neurolog pathway function also circadian clock regul daili photoperiod repres primari circadian synchron zeitgeb although divers studi point toward influenc dietari fas biolog clock comprehens literatur review conduct follow predefin select criteria aim updat evid molecular mechan behind circadian rhythm regul fas collect preclin clinic studi systemat review metanalys focus effect fas circadian rhythm twenti anim conduct rodent piglet human trial one observ studi provid evid regul neurolog inflammatoryimmun metabol reproduct cardiovascular biochem process fas via clock gene discuss evid suggest fas may serv non photic zeitgeb prove therapeut benefici circadian disrupt relat patholog futur work focus role clock gene target therapeut use fas inflammatori neurolog disord well bidirect associ molecular clock fas
|
D057906;D015525
|
T121;T123;T040;T109
|
36,293,014
|
effect high co strigolacton shoot branch aphid plant compat control pea elev atmospher co concentr eco regul plant architectur suscept insect explor mechan underpin respons wild type wt pea mutant defect either strigolacton sl synthesi signal genotyp increas shoot height branch dri weight carbohydr level eco demonstr sls requir shoot acclim eco sinc shoot level jasmon acid ja salicyl acid sa tend lower sl signal mutant wt ambient condit compar pea aphid perform line co condit aphid fecund increas sl mutant compar wt ambient eco condit aphid infest signific decreas level ja isopentenyladenin tran zeatin gibberellin increas ethylen precursor acc gibberellin gibberel acid ga sa accumul line howev ga level increas less sl signal mutant wt studi provid new insight phytohormon respons specif aphidhost interact suggest sls gibberellin part network phytohormon particip host suscept
|
D005875;D001042
|
T123;T204;T109
|
36,293,013
|
excess adventiti perivascular vascularis correl vascular inflamm intim hyperplasia albeit multipl studi demonstr vasa vasorum vv crucial import vascular patholog inform marker metric vascular inflamm defin develop intim hyperplasia ih vagu studi employ two rat model balloon injuri abdomin aorta intervent option complement intraven inject calciprotein particl clinic scenario arteri venous conduit coronari arteri bypass graft cabg surgeri investig pathophysiolog interconnect among vv myeloperoxidas posit mpo cluster ih found amount vv mpo cluster strong correl mpo cluster densiti signific associ balloon induc ih increas calciprotein particl provok endotheli dysfunct likewis number densiti vv correl ih bypass graft cabg surgeri pre intervent stage higher venous conduit frequent suffer ih compar arteri graft collect result underlin pathophysiolog import excess vv upon vascular injuri exposur cardiovascular risk factor highlight mpo cluster inform marker adventiti perivascular inflamm propos anoth mechanist explan higher long term patenc arteri graft upon cabg surgeri
|
D009195;D063194
|
T126;T116;T024
|
36,293,012
|
interact nlrp depend il type interferon pathway human plasmacytoid dendrit cell general reciproc antagonist interact exist antivir type interferon ifn antibacteri nucleotid bind oligomer domain nod like receptor pyrin domain contain nlrp depend il pathway signific shape immun respons plasmacytoid dendrit cell pdcs profession type ifn produc cell major coordin antivir immun howev nlrp depend il secretori pathway poor studi aim determin function activ il pathway possibl interact type ifn pathway pdcs found potent nuclear factor kappa b nf b induc promot higher level pro il prime compar activ signal main trigger interferon regulatori factor irf mediat type ifn product generat cleav il requir certain secondari signal pdcs ifn type ifn induc virus inhibit il product pdcs presum promot express various nlrp pathway inhibitor line detect signific lower il product pdcs psoriasi patient elev ifn level collect result show nlrp depend il secretori pathway induc pdcs howev may prevail inflammatori condit type ifn pathway domin
|
D000071199;D007370
|
T129;T123;T121;T116
|
36,293,011
|
killer cell immunoglobulin like receptor kir human leucocyt antigen c hla c increas risk long term chronic liver graft reject chronic liver reject cr repres complex clinic situat mani patient respond increas immunosuppress killer cell immunoglobulin like receptorsclass human leukocyt antigen kirhla interact allow predict natur killer nk cell alloreact influenc acut reject liver allograft howev mean cr liver graft remain controversi kir hla genotyp studi liver transplant use sequenc specif oligonucleotid pcr sso method kir human leucocyt antigen c hla c genotyp kir gene mismatch kirhla ligand analyz compar overal transplant cr n chronic reject ncr activ kir akir gene recipi rkird rkird increas cr compar ncr group p p inhibitori kir ikir gene recipi rkirdl signific increas cr rate compar absenc vs p kirdl signific increas cr vs p influenc ncr cr observ hla mismatch mm absenc donor hla c ligand dc ligand increas cr concern presenc vs p signific increas cr observ rkirdl dc p rkirdsdc p rkirdl rkird dc p long term patient surviv signific lower rkird rkird dc year post transplant studi show influenc rkirdhla c combin akir gene gene mismatch increas cr kird c ligand influenc kird c ligand long term graft surviv
|
D006086;D008107
|
T033;T047
|
36,293,010
|
function character synthet applic sdr novel thermost promiscu ketoreductas hot spring metagenom metagenom mine base search novel thermost hydroxysteroid dehydrogenas hsdhs enzym abl select oxidizereduc steroid compound novel short chain dehydrogenasereductas sdr name sdr recent discov enzym found iceland hot spring metagenom share high sequenc similar hsdhs unexpect show activ oxid test steroid substrat eg cholic acid despit sdr prove activ versatil ketoreductas abl regio stereoselect reduc diversifi panel carbonyl substrat includ bulki keton ketoest diketon pharmaceut relev investig show sdr inde activ regio stereoselect reduct oxid steroid deriv outcom ration dock analysi activ site model moreov sdr show remark thermost appar melt temperatur around c determin circular dichroism analysi signific decreas catalyt activ even h c broad toler water miscibl water immisc organ solvent demonstr well thus confirm potenti new biocatalyst synthet applic
|
D045482;D000074583
|
T070;T126;T116
|
36,293,009
|
genom wide identif dof gene famili mechan dissect sbdof regul starch biosynthesi sorghum starch one main util product sorghum sorghum bicolor l fifth largest cereal crop world regul mechan starch biosynthesi rare document sorghum present studi identifi gene encod c c zinc finger domain dof one three exon sorghum genom dof protein sorghum divid two type accord result sequenc align evolutionari analysi base gene express co express analysi identifi regulatori factor sbdof locat chromosom sbdof contain two exon encod kd protein compos amino acid sbdof co express gene involv sorghum starch biosynthesi pathway pearson correl coeffici pccs gene greater result qrt pcr assay indic sbdof high express sorghum grain exhibit low relat express level tissu root stem leav sbdof present typic dof transcript factor tf local nucleus possess transcript activ activ amino acid posit sbdof form import structur activ domain result emsa show sbdof could bind four tandem repeat p box tgtaaag motif vitro homolog protein zmdof ospbf tapbf meanwhil also discov sbdof could bind transactiv sbgbssi key gene sorghum amylos biosynthesi collect result present studi suggest sbdof act import regul sorghum starch biosynthesi exhibit potenti valu improv starch content sorghum
|
D045868
|
T002
|
36,293,008
|
divers sphingolipid speci harbor differ effect ire cluster endoplasm reticulum er function dedic multipl essenti process eukaryot includ process secretori protein biogenesi membran lipid role implic heavi burden organell thus prone fluctuat homeostasi molecul govern process unfold protein respons upr general er stress respons task maintain er optim function mediat master activ ire ire er transmembran protein initi upr form characterist oligom respons irregular lumin protein fold membran lipid environ role lipid regul upr remain relat obscur howev recent research reveal potent role sphingolipid activ identifi major role oxysterol bind protein kes whose activ consequ sphingolipid profil cell result inhibit upr activ use mcherri tag deriv ire observ occur due inhibit ire form oligom furthermor identifi sphingolipid presenc requir ire activ specif sphingolipid profil major consequ ire function addit highlight case ire oligomer absent despit activ upr reveal potenti mechan upr induct ire oligomer necessari work provid basi role sphingolipid control upr metabol harbor crucial role regul onset
|
D017346;D000072376
|
T123;T126;T116;T109
|
36,293,007
|
lncgsar control ovarian granulosa cell steroidogenesi via spong mir b activ scapsrebp pathway long non code rnas lncrnas shown play import role livestock fecund mani lncrnas affect follicular develop reproduct diseas identifi ovari howev function annot mechanist valid studi identifi new lncrna lncgsar investig effect prolifer steroidogenesi ovin granulosa cell gcs high concentr glucos add mm glucos caus high express lncgsar gcs regul stabil lncgsar overexpress promot gcs prolifer estrogen secret inhibit progesteron secret wherea interfer lncgasr opposit effect next found rna molecul lncgsar act mir b competit endogen rna cerna srebp cleavag activ protein scap verifi target mir b lncgasr overexpress increas express scap srebp steroid hormon relat protein attenu mir b result demonstr lncgsar act cerna activ scapsrebp signal spong mir b regul steroid hormon secret gcs find provid new insight mechan nutrient regul follicl develop ewe
|
D062085;D035683
|
T123;T114
|
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