PMID
int64 35.7M
36.4M
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36,293,006
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discoveri novel hiv proteas inhibitor use modern comput techniqu human immunodefici virus type hiv continu global concern new hiv incid emerg multi drug resist untoward side effect current use anti hiv drug urgent need discov effici anti hiv drug modern comput tool play vital role facilit drug discoveri process research focus pharmacophor base similar search screen uniqu compound pubchem databas discov novel hiv proteas inhibitor pis use silico approach involv similar search physicochem admet evalu hiv proteas inhibitor predict ic percent inhibit rigid receptor molecular dock studi bind free energi calcul molecular dynam md simul fda approv hiv pis saquinavir lopinavir ritonavir amprenavir fosamprenavir atazanavir nelfinavir darunavir tipranavir indinavir use refer silico analysi reveal fourteen twenti eight select optim hit molecul within accept rang paramet investig hit molecul demonstr signific bind affin hiv proteas pr compar refer drug import amino acid residu involv hydrogen bond stack interact includ asp gli asp asp ile interact help stabil optim hit molecul activ bind site hiv pr pdb id qk hps hps found promis term ic percent inhibit hiv pr addit drug metabol safeti profil hit candid investig possibl hiv pis improv efficaci low toxic vitro experi clinic trial investig
|
D017320;D015497;D019380
|
T121;T005
|
36,293,005
|
molecular physiolog effect brown agent white adipocyt bone marrow mesenchym stromal cell two differ type adipos depot observ mammal white adipos tissu wat brown adipos tissu bat primari role wat deposit surplus energi form triglycerid along mani metabol hormon activ thermogen tissu bat distinct characterist use energi glucos consumpt strategi maintain core bodi temperatur specif stimuli exercis cold exposur drug treatment white adipocyt util extraordinari flexibl transdifferenti brown like cell call beig adipocyt therebi acquir new morpholog physiolog characterist reason process identifi brown wat evalu abil drug includ gw sildenafil rosiglitazon induc brown process adult white adipocyt obtain differenti mesenchym stromal cell mscs addit broaden investig evalu potenti brown capac irisin myokin stimul muscular exercis data indic irisin effect promot brown white adipocyt acquir increas express ucp increas mitochondri mass modif metabol suggest increas mitochondri oxygen consumpt primarili presenc glucos nutrient promis brown agent repres appeal focus therapeut approach counteract metabol diseas associ obes
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D052438;D059630
|
T025
|
36,293,004
|
insight cytochrom p monooxygenas superfamili osmanthus fragran role ofcyp linalool synthesi osmanthus fragran flower long use raw materi food tea beverag perfum industri due attract strong fragranc p superfamili protein report wide particip synthesi plant floral volatil organ compound voc investig potenti function p superfamili protein fragranc synthesi fragran investig p superfamili genom wide total p gene identifi belong famili rna seq data suggest mani ofcyp gene preferenti express flower organ also induc multipl abiot stress express pattern seven flower preferenti express ofcyp five differ flower aroma content stage explor use quantit real time pcr show cypc subfamili member ofcyp highest posit correl linalool synthesi gene oftp transient express ofcyp fragran petal suggest ofcyp increas content linalool import voc fragran floral aroma similar result also obtain flower ofcyp transgen tobacco combin rna seq data transient transform fragran petal found biosynthesi pathway secondari metabolit signific enrich mani c methyl erythritol phosphat mep pathway gene also upregul evid indic ofcyp protein may play critic role flower develop abiot respons fragran ofcyp particip linalool synthesi studi provid valuabl inform function p gene valuabl guid studi function ofcyp promot fragranc biosynthesi ornament plant
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D055549;D010476;D029592
|
T073;T002;T109
|
36,293,003
|
experiment studi impact trace amount acetylen methylacetylen synthesi mechan thermal properti polypropylen product polym grade propylen differ process use purifi compound ensur highest qualiti howev impur acetylen methyl acetylen difficult remov impur may present propylen use obtain polypropylen may repercuss process studi evalu impact acetylen methyl acetylen impur product polypropylen synthesi process mechan thermal properti materi obtain synthesi eight sampl differ concentr acetylen eight sampl differ concentr acetylen discov first concentr acetylen ppm methyl acetylen mfi thermal record mechan properti resin unaffect variat fluiditi index thermal degrad tga mechan properti resist tension bend impact howev concentr exceed ppm methyl acetylen ppm acetylen resist resin began decreas linear regard product affect first trace acetylen methyl acetylen progress decreas
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D000114;D011126
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T122;T109
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36,293,002
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cytoskeleton element contribut prion peptid induc endotheli barrier breakdown blood brain barrier vitro system mechan involv interact prp peptid correspond prion protein amyloidogen region blood brain barrier bbb studi prp treatment previous shown impair bbb function reduc camp level cultur brain endotheli cell increas nitric oxid level chang activ mode small gtpase rac inactiv rhoa activ latter well establish regul endotheli barrier properti act via cytoskelet element inde liquid chromatographi mass spectrometri lc ms base proteom profil studi reveal extens chang express cytoskeleton relat protein result shed light natur interact prion peptid prp bbb emphas import cytoskeleton endothelium respons prion induc stress
|
D011328;D020559
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T005;T126;T116
|
36,293,001
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metabol relat gene prognost index predict respons immunotherapi lung adenocarcinoma immunotherapi immun checkpoint inhibitor ici valid strategi treat lung adenocarcinoma luad patient one main challeng ici treatment lack effici biomark predict respons resist metabol reprogram proven remodel tumor microenviron alter respons ici construct prognost model metabol relat gene mrg four gene use weight gene co express network analysi wgcna nonneg matrix factor nmf cox regress analysi luad dataset n cancer genom atlas tcga valid three gene express omnibus geo dataset n n n mrg construct base birc plk cdkn cypb gene mrg high patient wors surviv probabl mrg low patient furthermor mrg high subgroup associ cell cycl relat pathway high infiltr activ memori cd cell macrophag neutrophil show better respons ici contrarili mrg low subgroup associ fatti acid metabol high infiltr dendric cell rest mast cell show poor respons ici mrg promis prognost index predict surviv respons ici therapeut agent luad might provid insight strategi ici alon combin agent
|
D008175;D000077192
|
T191
|
36,293,000
|
engin immatur testicular tissu electrospun mat prepubert fertil preserv bioluminesc imag transgen mous model prepubert boy cancer may suffer reduc fertil matur follow gonadotox chemoradiotherapi thus viabl method immatur testicular tissu itt preserv requir cohort studi use poli l lactic acid electrospun scaffold two level fine support develop itt transplant transgen donor wild type recipi mice purpos studi evalu potenti itt transplant spermatogenesi use two scaffold employ bioluminesc imag evalu result suggest itt week old mice possess potenti spermatogenesi th day togeth fine electrospun scaffold moreov bioluminesc imag intens observ recipi mice day approxim six time coars electrospun scaffold control group occur sinc fine scaffold akin microenviron nativ testicular tissu reduc stiff result micron bodi fluid infiltr thermal analysi also exhibit recrystal biodegrad process lead stabl microenviron overal find present prospect fertil preserv prepubert male could serv framework futur applic
|
D059247
|
T061
|
36,292,999
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understand bacteriophag tail fiber interact host surfac receptor key blueprint reprogram phage host rang bacteriophag phage natur antibacteri agent rediscov grow threat multi pan drug resist bacteri pathogen global howev estim phage planet find right phage recogn specif bacteri host like look needl trillion haystack host rang phage primarili determin phage tail fiber spike initi mediat revers specif recognit adsorpt suscept bacteria recent signific advanc singl molecul atom level begun unravel structur organ tail fiber under mechan phage host interact discuss molecular mechan model tail fiber well character phage interact host surfac receptor structur function knowledg tail fiber pave way reprogram phage host rang bring futur benefit effect phage therapi medicin furthermor design strategi tail fiber engin briefli summar includ machin learn assist engin inspir increas enorm amount phage genet inform
|
D001435
|
T005
|
36,292,998
|
protect effect cbd model vitro ischemia may mediat agon trpv channel microglia activ cannabinoid use centuri recreat medic purpos potenti therapeut valu stroke treatment cannabidiol cbd non psychoact compound partial agonist trpv channel efficaci mani neurolog disord investig effect cbd tetrahydrocannabinol thc rat organotyp hippocamp slice expos oxygen glucos depriv ogd vitro model ischemia neuron trpv express decreas ogd increas activ phagocyt microglia cbd increas trpv express decreas microglia phagocytosi increas rod microglia ogd thc effect contrari cbd result show cannabinoid differ effect ischemia cbd show neuroprotect effect mediat least part trpv channel sinc trpv antagonist tranilast block thc worsen neurodegener caus ischemia conclus result suggest differ cannabinoid molecul play differ role mechan post ischem neuron death differ effect cannabinoid observ experi caution indiscrimin use cannabi cannabinoid prepar recreat therapeut use observ posit effect cbd may counteract negat effect caus high level thc
|
D002185;D018696;D002188;D002186
|
T121;T167;T109;T169;T002
|
36,292,997
|
ift eclect regul cellular process beyond intraflagellar transport initi discov smallest compon intraflagellar transport ift system ift protein found implic sever unconvent mechan beyond essenti role assembl mainten primari cilium ift consid key player ciliogenesi also vesicular traffick membran receptor signal protein moreov abil associ wide array interact partner cell type specif manner expand function ift regul intracellular degrad secretori pathway review present overview multifacet role ift ciliat non ciliat cell
|
D002352;D002468
|
T123;T116;T043
|
36,292,996
|
clinic relev circul tumor cell breast cancer epitheli mesenchym characterist singl cell cluster metastat breast cancer mbc typic incur diseas high mortal rate thus earli identif metastat featur diseas recurr precis biomark crucial circul tumor cell ctcs consist heterogen subpopul differ morpholog genet epigenet gene express profil repres promis candid biomark metastat potenti experiment verifi role epitheli mesenchym transit cancer dissemin clear describ bc patient stem featur ctcs strong contribut metastat potenc singl ctcs shown protect bloodstream recognit immun system impair interact lymphocyt nk cell associ heterotyp ctc cluster platelet leucocyt neutrophil tumor associ macrophag fibroblast improv tumorigen behavior addit singl ctc ctc cluster characterist review ctc evalu method clinic studi earli metastat bcs variabl ctc test develop base specif principl strategi howev ctc count presenc ctc cluster shown clinic relev exist clinic trial despit known progress ctc research sampl bc patient implement ctcs ctc cluster routin diagnost treatment strategi still requir improv detect sensit precis molecular character focus predomin role ctc cluster higher metastat potenc
|
D009360;D001943
|
T191;T025
|
36,292,995
|
singl cell analysi better understand mechan involv ms multipl sclerosi chronic inflammatori diseas central nervous system although diseas wide studi mani precis mechan involv still well known numer studi current focus multipl sclerosi highlight involv mani major immun cell subset cd cell cd cell recent b cell howev vision patholog remain broad allow proper use target therapeut past decad new technolog emerg enabl deeper research differ cell subset singl cell level peripheri central nervous system technolog could allow us identifi new cell popul involv diseas process new therapeut target review briefli introduc major singl cell technolog current use studi dive major find multipl sclerosi research past year focus result obtain use singl cell technolog studi immun cell cell central nervous system
|
D059010;D009103
|
T047;T059
|
36,292,994
|
iron defici promot lack photosynthet cytochrom c affect bind lumin extrins subunit photosystem ii diatom phaeodactylum tricornutum diatom phaeodactylum tricornutum iron limit promot decreas content photosystem ii determin measur oxygen evolv activ thermoluminesc chlorophyl fluoresc analys protein quantif method thermoluminesc experi also indic iron limit induc subtl chang energet recombin reaction reduc q b state water split machineri howev electron transfer q q b involv non heme iron seem signific inhibit moreov iron defici promot sever decreas content extrins psbvcytochrom c subunit photosystem ii appear eukaryot alga red photosynthet lineag includ diatom absent green alga plant declin content cytochrom c iron limit condit accompani decreas bind protein photosystem ii also extrins psbo subunit propos lack cytochrom c induc iron defici specif affect bind extrins subunit photosystem ii previous describ cyanobacteri psbv mutant
|
D017377;D000090463
|
T047;T204
|
36,292,993
|
pathogenesi port wine stain direct futur therapi port wine stain pwss congenit vascular malform involv skin mucosa date mechan under pathogenesi progress pwss yet clear elucid potenti reason dilat vessel follow somat gnaq rq mutat form enlarg capillari malform like vessel angiopoietin decreas perivascular nerv element coexist eph receptor b ephrin b defici sma express pericyt addit erk c jnk psk akt pik pkc assum involv pws develop although puls dye laser pdl remain gold standard treat pwss recurr rate high topic drug includ imiquimod axitinib rapamycin combin pdl treatment expect alter recurr rate reduc number pdl session pwss deep vascular plexus photosensit phototherm transduct agent encapsul nanocarri conjug surfac marker cdcdvegfr possess promis therapeut potenti photodynam therapi phototherm therapi pwss pathogenesi progress treatment pwss extens investig
|
D019339
|
T019
|
36,292,992
|
sexual dimorph gut microbiota chines allig converg wild environ gut microbiota form complex microecosystem vertebr affect various factor key intrins factor sex persist impact format develop gut microbiota studi analyz sexual dimorph gut microbiota particular wild anim use rrna gene sequenc analyz gut microbiota juvenil adult chines allig untarget metabolom studi serum metabolom adult allig observ signific sexual differ communiti divers juvenil adult allig term taxonom composit phylum fusobacteriota genus cetobacterium high abund adult allig similar present carnivor fish wherea gut microbiota composit juvenil allig resembl terrestri reptil indic adult affect wild aquat environ lack sex dimorph gut microbiota correl analysi reveal gut microbiota adult also affect cyanobacteria extern environ effect sex bias mediat sex hormon overal studi reveal sexual differ gut microbiota crocodilian converg extern environ also provid insight host microbiota interact wildlif
|
D000489;D000069196
|
T014;T007;T001
|
36,292,991
|
impact ros depend lipid metabol psoriasi pathophysiolog psoriasi common autoimmun diseas yet pathophysiolog fulli understood believ psoriasi caus increas activ immun cell especi th lymphocyt howev psoriasi immun cell interfer metabol keratinocyt lead increas activ therefor pathophysiolog psoriasi current associ overproduct ros involv activ immun cell keratinocyt well modul various signal pathway within nevertheless ros modul immun system also boost increas generat various lipid mediat product lipid peroxid well endocannabinoid prostaglandin psoriasi excess generat ros lipid mediat observ differ immun cell granulocyt dendrit cell lymphocyt may activ ros lipid mediat lead inflamm nevertheless ros lipid mediat regul lymphocyt differenti favor th may also interact direct keratinocyt also observ psoriasi thus analysi influenc oxid stress consequ metabol chang includ lipidom one psoriasi may diagnost therapeut import
|
D050356;D011565
|
T047;T044
|
36,292,990
|
character copperzinc superoxid dismutas activ phascolosoma esculenta sipuncula phascolosomatidea protect oxid stress induc cadmium phascolosoma esculenta econom import speci inhabit high tide area intertid zone particular sensit water pollut consid potenti bioindic studi ecotoxicolog p esculenta imper toxic effect cadmium cd analyz expos p esculenta differ concentr cd mgl studi chang antioxid index total superoxid dismutas sod glutathion transferas gst reduc glutathion gsh microscal malondialdehyd mda record copperzinc superoxid dismutas cuzn sod one import free radic scaveng member reveal antioxid function p esculenta import member antioxid system design pe cuzn sod clone analyz phylogen analysi reveal pe cuzn sod locat invertebr evolutionari branch intracellular cuzn sod iccuzn sod quantit real time polymeras chain reaction result show pe cuzn sod messeng ribonucl acid wide express tissu examin highest express level coelom fluid cd exposur indic function stress respons use prokaryot express system obtain pe cuzn sod recombin protein enhanc heavi metal toler escherichia coli vivo assay also confirm pe cuzn sod recombin protein antioxid free radic scaveng abil cd toxic experi purifi pe cuzn sod protein inject bodi caviti p esculenta show reactiv oxygen speci content coelom fluid experiment group signific lower compar control group result suggest pe cuzn sod play role cd detoxif chelat heavi metal ion scaveng reactiv oxygen free radic p esculenta could use bioindic evalu heavi metal pollut
|
D002104;D019216
|
T131;T196
|
36,292,989
|
non genet modifi synapt plastic neurotransmiss central nervous system cns health diseas special edit intend focus influenc non genet factor modifi synapt plastic neurotransmiss health diseas
|
D009435;D009473
|
T042;T043
|
36,292,988
|
solid fe resourc separ roll oil sludg co oxid effici recycl valuabl resourc roll oil sludg ros gain new use remain formid challeng studi report recycl solid fe resourc ros catalyt hydrogen techniqu catalyt perform co oxid solid fe resourc calcin air fe h exhibit compar activ prepar calcin ferric nitrat fe c suggest solid resourc excel recycl valu use raw materi co oxid catalyst prepar studi improv catalyt perform support materi high surfac area x zeolit pretreat materi co atmospher show co pretreat great improv co oxid activ best activ achiev wt fe hx sampl complet co convers c co pretreat could produc oxygen vacanc facilit activ thus acceler co oxid reaction rate excel reduc suffici adsorpt amount also favor perform recycl solid fe resourc ros quit promis co oxid applic
|
D012722;D017641
|
T197;T069
|
36,292,987
|
poison piperidin plant biodivers norditerpenoid alkaloid lead drug discoveri experiment aspect famous exampl simpl eg hemlock conium maculatum l complex eg opium poppi papav somniferum l papaveracea piperidin alkaloid contain plant mani high poison whilst pepper well known gastronom sever substitut piperidin alkaloid therapeut benefici function dose mode action review cover taxonomi genera aconitum delphinium controversi consolida part studi biodivers norditerpenoid alkaloid ndas major possess n ethyl group also quantifi fragment occurr count scifind databas nda skeleton wide rang nda biodivers also captur review recent report isol alkaloid ring substitut posit import determin nda skeleton conform overview natur occur high oxygen ndas tradit aconitum delphinium plant consider given function effect real function evid high potenti biolog activ make use candid molecul investig lead compound develop select drug
|
D000470;D031841;D004224;D010207
|
T123;T121;T109;T131;T002
|
36,292,986
|
function zinc sens receptor gpr regul intestin health anim g protein coupl receptor gpr zinc sens receptor znr sens chang extracellular zn mediat zn signal transmiss particip regul numer physiolog activ live organ exampl gpr activ extracellular signal regul kinasemitogen activ protein kinas erkmapk phosphatidylinositol kinaseprotein kinas b pikakt signal pathway upon zn stimul enhanc prolifer differenti colon cell regul ion transport well exert function recent year increas attent anim gut health issu intens research gpr gpr becom potenti target regul anim intestin health one hand gpr involv regul ion transport anim intestin mediat cl efflux activ k cl synergist protein transport reliev diarrhea symptom hand gpr maintain homeostasi anim intestin promot ph restor colon cell regul gastric acid secret facilit nutrient absorpt addit gpr affect express tight junction protein intestin epitheli cell improv barrier function anim intestin mucosa maintain integr intestin review summar structur signal transduct process involv gpr effect gpr regul intestin health anim aim highlight role gpr regul anim intestin health provid new direct idea studi prevent treatment anim intestin diseas
|
D051057;D015032
|
T123;T121;T116;T196;T126
|
36,292,985
|
phenotyp flexibl egfrviii posit glioblastoma cell line multidirect influenc tgf egf cell egfrviii appear weak oncogen biolog role egfrviii epiderm growth factor receptor variant three remain unclear
|
D005909;D000076962
|
T129;T191;T116;T192
|
36,292,984
|
mitochondri dna chang gene respiratori complex iii iv v could relat brain tumour human mitochondri dna chang contribut increas decreas likelihood cancer process complex fulli understood polymorph mutat especi missens type affect mitochondri function particular conserv domain protein concern studi aim identifi possibl relationship brain glioma occurr specif mitochondri dna polymorph mutat respiratori complex iii iv v investig materi includ blood tumour materi collect caucasian patient diagnos grade ii iii iv glioma mitochondri genet variant investig across mitochondri genom use next generat sequenc miseqfgx system illumina studi investig silico effect missens mutat biochem properti structur function encod protein well potenti harm ag mtcyb ag mt cyb ag mt cyb ga mt co polymorph tc mt cyb ga atp mutat assess silico harm alter could involv oncogenesi ga ek atp missens mutat describ literatur far light result research role mtdna chang brain tumour conduct
|
D054629;D001932
|
T191;T028
|
36,292,983
|
genet variant nicotin receptor subunit caus sleep relat hyperkinet epilepsi via increas channel open describ genet molecular level function alter neuron nicotin acetylcholin receptor nachr patient sleep relat hyperkinet epilepsi famili histori epilepsi genet sequenc reveal heterozyg variant cc gt g chrna gene encod subunit result missens mutat psertrp patch clamp record genet engin nachr incorpor sertrp subunit reveal aberr channel open absenc agonist mark prolong open presenc measur singl channel current amplitud distinguish two pentamer stoichiometri variant nachr contain either two three copi sertrp subunit exhibit aberr spontan prolong agonist elicit channel open ser residu high conserv locat within transmembran helix line ion channel map onto receptor three dimension structur larger trp substitut steric clash helix neighbor subunit promot expans pore stabil open relat close conform channel togeth clinic genet function structur observ demonstr sertrp enhanc channel open predict increas membran excit pathogen seizur phenotyp
|
D011978
|
T116;T192
|
36,292,982
|
present two unrel clinic case republ north ossetia alania previous undescrib variant cola gene describ three affect boy two unrel famili ossetian digor origin republ north ossetia alania admit research centr medic genet unspecifi muscular dystrophi high throughput sequenc perform reveal two novel frameshift variant cola gene nm heterozyg state case cdelinsctgtgg cdel case cdel cdel case two case nucleotid variant cola gene cdel observ suggest variant cdel may common ossetian digor popul two analyz famili ancestri subethn group ossetian screen asymptomat carriag nucleotid variant cdel healthi donor ossetian digor popul reveal estim carrier frequenc ci high healthi carrier pathogen variant molecular genet anamnest data clinic examin result allow us diagnos ullrich muscular dystrophi affect boy genet heterogen phenotyp divers muscular dystrophi complic diagnosi import make differenti diagnosi condit use hts method determin accur diagnosi
|
D009136
|
T047
|
36,292,981
|
develop sensit screen method simultan determin nine genotox nitrosamin activ pharmaceut ingredi gc ms worldwid crisi nitrosamin contamin medic product began therefor trace level analysi nitrosamin becom emerg topic interest field qualiti control novel gc ms method electron ionize microextract develop valid simultan determin nine carcinogen nitrosamin ndma nmea ndea ndba nmor npyr npip ndpa n methyl npz activ pharmaceut ingredi api cilostazol sunitinib malat olmesartan medoxomil method valid accord intern council harmonis technic requir pharmaceut human use ich guidelin demonstr good linear rang loq ngml specif limit limit detect nine nitrosamin determin rang ngml develop trace level gc ms method turn specif accur precis accuraci test api rang precis evalu repeat intermedi precis system precis rsd nitrosamin detect cilostazol sunitinib wherea olmesartan medoxomil ndea detect level loq novel protocol success appli nitrosamin determin select api use routin qualiti control api good manufactur practic rule ensur safeti effect pharmaceut product
|
D009602
|
T131;T109
|
36,292,980
|
mitophagi relat gene signatur subtyp identif prognosi predict hepatocellular carcinoma global hepatocellular carcinoma hcc sixth common cancer studi correl mitophagi hcc prognosi evalu use data cancer genom atlas tcga clinic transcriptom data hcc patient download tcga dataset mitophagi relat gene mrg dataset obtain molecular signatur databas consensus cluster analysi perform classifi patient two cluster furthermor tumor prognosi clinicopatholog featur function analysi immun infiltr immun checkpoint ic relat gene express level tumor stem cell ferroptosi status n methyladenosin analysi compar two cluster final mitophagi relat signatur develop two cluster c c identifi use consensus cluster analysi base mrg signatur patient c subtyp exhibit upregul pathway better liver function downregul cancer relat pathway lower cancer stem cell score lower tumor immun dysfunct exclus score tide differ ferroptosi status better prognosi compar patient c subtyp c subtyp character increas grade hcc well increas number immun relat pathway relat gene higher immun score also observ c subtyp signatur contain four mrgs pgam sqstm atga gabarapl accur predict prognosi hcc patient identifi four gene signatur exhibit predict effect five cancer type name glioma uveal melanoma acut myeloid leukemia adrenocort carcinoma mesothelioma mitophagi associ subtyp hcc close relat immun microenviron immun checkpoint relat gene express cancer stem cell ferroptosi status prognosi hcc progress establish mrg signatur could predict prognosi patient hcc
|
D006528;D008113
|
T191
|
36,292,979
|
lipas catalyz transesterif model long chain molecul doubl shell cellulos coat oil water emuls particl microbioreactor lipas catalyz transesterif preval industri product effect altern chemic catalysi howev due lipas uniqu structur reaction requir biphas system suffer low reaction effici caus limit interfaci area use emuls particl found effect way increas surfac area activ research focus cellulos natur surfact oil water emuls evalu abil lipas introduc emuls aqueous phase integr emuls microparticl catalyz transesterif reaction high molecular weight ester dissolv particl core cellulos coat emuls particl morpholog investig light fluoresc cryogen scan electron microscopi reveal complex emuls structur lipas activ evalu measur hydrolysi emulsifi p nitrophenyl dodecano transesterif emulsifi methyl laurat oleyl alcohol dissolv decan experi demonstr lipas introduc aqueous medium penetr emuls particl local inner oil core interfac perform effect catalysi furthermor system lipas success catalyz transesterif reaction rather hydrolysi despit domin presenc water
|
D008049;D002482
|
T123;T121;T116;T109;T126;T122
|
36,292,978
|
domin prime role waterlog tomato e co multivari analysi frequenc waterlog episod increas due unpredict intens rainfal howev less known waterlog memori interact climat chang event elev co concentr e co studi investig combin effect e co two round waterlog stress growth cultiv tomato solanum lycopersicum wild tomato pimpinellifolium aim elucid interact genotyp environment factor therebi improv crop resili climat chang found two round treatment appear induc differ acclim strategi two tomato genotyp pimpinellifolium respond negat first time waterlog lycopersicum indic decreas photosynthesi biomass loss nevertheless two genotyp respond similar waterlog stress recur show could maintain higher leaf photosynthesi compar singl stress especi wild genotyp show waterlog prime play posit role stress memori tomato genotyp multivari analysi show waterlog play domin role combin co cultiv wild tomato genotyp work benefit agricultur product strategi pinpoint posit effect e co waterlog memori
|
D018551;D032322
|
T168;T002
|
36,292,977
|
de novo assembl sarcocarp transcriptom set identifi aamyb regul anthocyanin biosynthesi actinidia arguta var purpurea kiwifruit actinidia arguta var purpurea produc oval shape fruit contain slight green mauv outer exocarp purpl flesh endocarp row tini black seed flesh color fruit result rang anthocyanin compound import trait kiwifruit consum elucid molecular mechan involv anthocyanin biosynthesi sarcocarp arguta fruit develop de novo assembl transcriptom profil analys perform base signific gene ontolog go biolog term differenti express gene identifi flavonoid biosynthet metabol process pigment biosynthesi carbohydr metabol process amino acid metabol process gene close relat anthocyanin biosynthesi phenylalanin ammonia lyas pal chalcon synthas chs anthocyanidin synthas an display signific regul fruit develop accord transcriptom data confirm qrt pcr meanwhil seri transcript factor gene identifi among deg correl analysi aamyb found signific correl key gene anthocyanin biosynthesi especi chs transient express assay aamyb induc anthocyanin accumul tobacco leav data provid import basi explor relat mechan sarcocarp anthocyanin biosynthesi arguta studi provid strong foundat function studi arguta facilit improv breed arguta fruit
|
D029042
|
T002
|
36,292,976
|
gemcitabin paclitaxel chemotherapi patient advanc urotheli cancer refractori cisplatin base chemotherapi predict role pgk treatment respons cytotox chemotherapi investig altern immun checkpoint inhibitor advanc urotheli cancer auc biolog inform urgent need clinic data patient receiv gemcitabin paclitaxel therapi gp nd line chemotherapi auc refractori platinum base chemotherapi retrospect review efficaci toler gp evalu predict valu phosphoglycer kinas pgk immunostain surgic specimen investig treatment outcom st nd line chemotherapi gp associ object respons rate median overal surviv durat month multivari analysi show ps st nd line non respons independ predictor wors progress free surviv ps st line non respons independ predictor wors overal surviv advers event manag therapi relat death occur non respons rate st line chemotherapi signific higher patient high express pgk nucleus low express p studi demonstr efficaci toler nd line gp patient auc refractori platinum base chemotherapi moreov pgk nucleus predict valu resist platinum base chemotherapi auc
|
D002295;D001688
|
T121;T123;T191
|
36,292,975
|
subacut pulmonari toxic glutaraldehyd aerosol human vitro airway tissu model glutaraldehyd ga clear center devic radiolog health cdrh food drug administr fda high level disinfect disinfect heat sensit medic equip hospit healthcar facil inhal exposur ga known caus respiratori irrit sensit anim human reproduc known vivo effect elicit ga use liquid aerosol exposur system evalu tissu respons human vitro airway epitheli tissu model cultur treat air interfac various concentr ga aerosol five consecut day chang tissu function structur evalu select timepoint treatment phase day recoveri period exposur ga aerosol caus oxid stress inhibit ciliari beat frequenc aberr mucin product disturb cytokin matrix metalloproteinas secret well morpholog transform effect goblet cell ciliat cell persist follow day recoveri period note function structur disturb observ ga treat cultur resembl found ortho phthaldehyd opa treat cultur furthermor vitro find ga toxic partial qualit mimick report anim human survey studi taken togeth observ studi demonstr human air liquid interfac ali airway tissu model integr vitro exposur system simul human inhal exposur could use vitro base human hazard identif risk character aerosol chemic
|
D020397;D004202
|
T131;T025;T167
|
36,292,974
|
character involv exosom origin chikungunya virus infect epitheli cell transmiss infecti viral element chikungunya virus chikv mosquito born alphavirus affect world popula tion chikungunya diseas adapt viral life cycl host cell environ key step establish infect pathogenesi recent accumul evid advoc princip role extracellular vesicl ev includ exosom infect pathogenesi infecti diseas howev particip exosom chikv infec tion transmiss well clarifi demonstr chikv rna pro tein captur exosom releas viral infect epitheli cell viral genom element isol exosom infecti nave mammalian epitheli cell assay particl size distribut transmiss electron microscopi tem reveal chikv deriv exosom size rang nm treatment rnase triton x immunoglobulin g antibodi chikv posit patient plasma indic fectious viral element encompass insid exosom interest viral plaqu mation also exhibit infecti viral element might secur transmit neighbor cell secret exosom pathway taken togeth recent find emphas evid complementari mean chikv infect suggest role exosom mediat chikv transmiss
|
D002646;D055354;D065632
|
T026;T005;T047
|
36,292,973
|
effect subthalam stimul electrod implant striatal microenviron parkinson diseas rat model deep brain stimul dbs subthalam nucleus stn consid gold standard treatment pd howev under therapeut mechan need comprehens elucid especi relat glial cell aim understand effect stn microles stn dbs striatal glial cell inflamm extracellular glutamategabaerg concentr hydroxydopamin ohda induc pd rat model rat unilater striatal ohda electrod implant stn divid two group dbs dbs day hday salin ohda anim use control akinesia striatal reactiv astrocyt microglia inflammasom express cytokin cell signal excitatori amino acid transport eaat examin moreov striatal microdialysi perform evalu glutam gaba concentr pd rat model exhibit akinesia increas inflamm glutam releas decreas glutamaterg clearanc striatum stn dbs dbs complet abolish akinesia stn microles stn dbs decreas striatal cytokin express relat concentr extracellular glutam howev stn dbs inhibit morpholog chang astrocyt decreas inflammasom reactiv increas eaat express striatum collect find suggest benefici effect dbs mediat combin stimul local microles involv inhibit glial cell activ neuroinflamm glutam excitotox
|
D010300;D046690
|
T061;T047
|
36,292,972
|
role star scpscpx transport cholesterol lipid cholesterol lipid molecul essenti sever key cellular process includ steroidogenesi traffick distribut cholesterol tight regul various pathway includ vesicular non vesicular mechan one non vesicular mechan bind cholesterol cholesterol transport protein facilit movement cholesterol cellular membran classic exampl cholesterol transport protein steroidogen acut regulatori protein star stard facilit cholesterol transport acut steroidogenesi mitochondria sterol carrier protein sterol carrier protein x scpscpx non specif lipid transfer protein involv transport metabol mani lipid includ cholesterol sever cellular compart review discuss role star scpscpx cholesterol transport model cholesterol transport protein well recent find support role protein transport andor metabol lipid
|
D002352;D002784
|
T123;T121;T116;T109
|
36,292,971
|
genom wide classif phylogenet analys gdsl type esteraselipas gelp famili flower plant gdsl type esteraselipas gelp enzym key function plant development process anther pollen develop respons biotic abiot stress gene encod gelp belong complex larg gene famili rang ten hundr member per plant speci facilit function transfer conduct genom wide classif gelp plant speci first appli iter phylogenet method use select set repres angiosperm genom three monocot five dicot identifi main cluster subdivid orthogroup og expert curat gene structur orthogroup composit function annot made base literatur review use hmm profil seed expand classif plant speci result reveal variabl evolutionari dynam og expand most tandem duplic other maintain singl copi among dicot specif cluster specif amplif monocot wheat character approach combin manual curat automat identif effect character larg gene famili allow establish classif framework gene function transfer better understand evolutionari histori gelp
|
D004950;D019684
|
T126;T116;T002
|
36,292,970
|
ex vivo fluoresc confoc microscopi fcm ensur repres tissu prostat cancer biobank feasibl studi biobank prostat carcinoma particular challeng due actual cancer within organ often without clear margin frozen section date way examin biobank materi tumor content use ex vivo fluoresc confoc microscopi fcm analyz biobank sampl prior cryoasserv
|
D018070;D011471
|
T191;T093
|
36,292,969
|
copper amin oxidas cuao mediat polyamin catabol play potenti role sweet cherri prunus avium l fruit develop ripen copper amin oxidas cuao play import role pa catabol plant growth develop abiot stress respons order better understand pa affect cherri fruit four potenti pavcuao gene pavcuao pavcuao dispers two chromosom identifi sweet cherri genom base phylogenet analysi classifi three subclass rna seq analysi show pavcuao gene tissu specif most high express flower young leav mani cis element associ phytohormon stress respons predict kb upstream region promot pavcuao transcript level increas respons abscis acid aba gibberellin ga treatment well abiot stress nacl peg cold quantit fluoresc analysi high perform liquid chromatographi confirm put content fell pavcuao mrna level rose sweet cherri fruit ripen genet transform arabidopsi pavcuao put content transgen plant decreas signific express aba synthesi gene nced also signific increas time excess h produc pavcuao transient express tobacco leav result strong prove pavcuao decompos put may promot fruit ripen increas content aba h suppress total free pa level fruit
|
D000068220;D006631;D017360
|
T129;T121;T116;T126;T002
|
36,292,968
|
oxid stress amelior novel peptid extract enzymat hydrolys chines pecan cake pecan carya cathayensi import econom crop hydrolyz peptid evidenc reduc effect oxid stress due antioxid capac henc protocol ultrafiltr gel filtrat chromatographi establish obtain bioactiv peptid product c cathayensi pecan cake measur dpphabt radic scaveng peptid less molecular weight mw possess higher antioxid capac pcph iii mw lt kda present higher radic scaveng capac pcph ii kda lt mw lt kda pcph mw gt kda measur dpph ic g ml measur abt ic gml secondari structur amino acid composit vari mw pcph ii contain helic sheet pcph iii contain higher ratio turn composit differ secondari pcph even variat trend helix random experienc slight vari pcph pcph ii signific decreas pcph ii pcph iii increas antioxid capac follow content prolin pcph iii highest composit regard six peptid identifi lc msms two vygyadk vlfsni show stronger antioxid capac other silico molecular dock demonstr combin abil transcript factor kelch like ech associ protein keap specul inhibit oxid stress activ keap nrf pathway meanwhil increas activ sod cat antioxid marker found h induc cell residu tyrosin demonstr contribut antioxid capac vygyadk posit affect less studi provid novel peptid screen product util process appli natur product develop
|
D031325;D001688
|
T168;T121;T123;T002
|
36,292,967
|
role ion channel mainten sperm motil swim behavior marin teleost ovipar marin fish hyperosmot induct sperm motil seawat sw well establish howev potenti function ion channel mainten post activ spermatozoon swim perform remain larg unknown investig influenc ion channel spermatozoon swim paramet use gilthead seabream sparus aurata model modern marin teleost data show sw induc activ seabream sperm motil requir three concomit process hyperosmot shock ion flux independ increas intracellular concentr ca ca k na alkal cytosol combin three process obligatori trigger flagellar beat howev time cours monitor sperm motion kinet chang ca k na sw non ionic activ media show post activ mainten spermatozoa motil depend extracellular ca k meta analysi seabream sperm transcriptom uncov express multipl ion channel immunoloc head andor tail spermatozoon select pharmacolog inhibit ion channel famili impair long term motil progress veloc sw activ spermatozoa data reveal antagonist k select ca select channel well stretch activ mechanosensit channel alter trajectori spermatozoa suggest ion channel like involv control swim pattern post activ spermatozoon combin find provid new insight signal pathway regul spermatozoon activ swim perform marin fish
|
D013081;D021541
|
T013;T043
|
36,292,966
|
nigella sativa l activ compound thymoquinon clinic manag diabet systemat review despit exist convent hypoglycem drug manag diabet non avail cost low incom countri coupl associ side effect remain major concern consequ explor altern treatment manag diabet continu prioriti nigella sativa l ns famili ranunculacea regard valuabl tradit remedi diabet manag extens studi biolog properti systemat review provid comprehens critic analysi clinic studi efficaci safeti mechan action ns compound thymoquinon tq diabet manag main scientif databas scrutinis scopus pubm googl scholar web scienc data search conduct incept januari total clinic studi obtain studi nigella sativa l studi compound tq n sativa found high potent term hypoglycem activ compar placebo base improv paramet includ fast blood glucos fbg postprandi blood glucos ppbg hemoglobin ac hbac homeostat model assess insulin resist homa ir homeostat model assess assess beta cell function homa compound tq combin daili dose metformin demonstr greater reduct level hbac blood glucos compar metformin alon bioavail tq enhanc use nanoparticul drug deliveri system consid find clinic studi along neglig advers effect ns strong potenti applic bioproduct develop manag diabet investig explor detail mechan action tq exert therapeut antidiabet effect provid insight clinic use manag diabet
|
D031881;D003920;D008687
|
T121;T047;T002;T109
|
36,292,965
|
methylom profil fabri diseas clinic practic proof concept anderson fabri diseas fd x link diseas caus function deficit galactosidas enzym fd diagnosi reli clinic manifest research gla gene mutat howev lack clear genotypephenotyp correl fd diagnosi challeng recent sever studi highlight import investig dna methyl pattern confirm correct diagnosi differ rare mendelian diseas date studi report fd thus present investig analyz first time genom wide methyl profil well character cohort patient fabri diseas profil methyl status cpg site fd patient carri mutat gla gene exon cc gt g present compar low level gal activ found although whole methylom profil discrimin fd group unaffect one sever gene signific differenti methyl fabri patient thus provid proof concept test patient differ mutat larger cohort methyl state specif gene potenti identifi fabri patient possibl predict organ involv diseas evolut
|
D000795
|
T047
|
36,292,964
|
compar genom phylogenet analysi chloroplast genom three medicin salvia speci bioexplor systemat determin phylogenet relationship develop molecular marker speci discrimin salvia bowleyana splenden officinali sequenc chloroplast genom use illumina hiseq platform chloroplast genom length bowleyana splenden officinali bp bp bp respect six gene ndh b rpl rpl rps rps ycf present ir region chloroplast genom bowleyana splenden officinali contain tandem repeat simpl sequenc repeat interspers repeat respect three specif intergen sequenc ig rps trn q uug trn l uaa trn f gaa trn cau atp e found discrimin salvia speci total intergen spacer sequenc identifi genet distanc analysi two specif ig region trn g gcc trn cau ycf trn gga highest kp valu identifi three studi salvia speci furthermor phylogenet tree show salvia speci form monophylet group two pair genus specif dna barcod primer found result provid solid foundat understand phylogenet classif three salvia speci moreov specif intergen region provid probabl discrimin salvia speci phenotyp distinct gene fragment
|
D054628;D027544
|
T002;T028
|
36,292,963
|
tmao upregul member mir cluster impact target associ atherosclerosi atherosclerosi hallmark cardiovascular diseas lifestyl strong impact onset progress nutrient shown regul mir cluster role endotheli function atherosclerosi cholin betain l carnitin found anim food metabol trimethylamin tma gut microbiota tma oxid tmao associ atherosclerosi aim investig whether tmao modul express mir cluster along impact modul express target gene relat atherosclerosi inflamm treat hepg cell thp cell murin liver organoid human peripher mononuclear cell tmao differ timepoint tmao increas express analyz member cluster except mir p murin liver organoid primari human macrophag gene protein level serpin il increas associ atherosclerosi cardiovascular diseas cdvd indirect modul mir cluster conclud tmao modul express mir cluster modul could promot inflamm il blood clot serpin express could ultim promot atherosclerosi cvd
|
D002318;D050197;D035683
|
T123;T047;T046;T114
|
36,292,962
|
sodium algin natur microencapsul materi polymer microparticl multitud materi current avail market use develop microparticl sodium algin becom one studi natur anion polym includ control releas pharmaceut system alongsid polym due low cost low toxic biocompat biodegrad gelatin die form capac presenc ca ion review shown coacerv particul system dispens drug consist natur polym nontox allow repeat administr medicin substanc protect better medicin substanc degrad increas captur capac drug extend releas pharmaceut form
|
D000464;D011108
|
T121;T122;T104;T109
|
36,292,961
|
potenti molecular mechan behind ultra high dose rate flash effect flash radiotherapi deliveri dose ultra high dose rate gt gys recent emerg promis tool enhanc therapeut index cancer treatment remark spare normal tissu equival tumor control flash irradi compar convent dose rate irradi flash effect alreadi demonstr sever preclin model even first patient cell cutan lymphoma howev biolog mechan respons differenti effect produc flash irradi normal cancer cell remain elucid great import good understand under radiobiolog mechan character specif beam paramet requir success clinic translat flash radiotherapi review summar flash investig perform far critic evalu current hypothes explain flash effect includ oxygen deplet product reactiv oxygen speci alter immun respons also propos new theori assum import role mitochondria mediat normal tissu tumor respons flash dose rate
|
D009369
|
T191
|
36,292,960
|
upregul mir mir ev renal cell undergo emt urin diabet nephropathi patient diabet nephropathi dn sever kidney relat complic type type diabet frequent caus end stage kidney diseas extracellular vesicl ev present urin main deriv cell nephron thus repres interest tool mirror kidney physiolog state search biomark diseas progress assess panel urinari ev mirna previous relat dn type diabet patient stratifi base proteinuria level found dn progress mir mir specif increas urinari ev diabet patient togeth albuminuria vitro mirna modul assess model tgf induc glomerular damag within three dimension perfus system well model tubular damag induc albumin glucos overload renal tubular cell podocyt undergo epitheli mesenchym transit releas ev contain increas mir mir level time mir level reduc ev releas glomerular endotheli cell work highlight modul mir mir progress kidney damag diabet biomark epitheli mesenchym transit
|
D003928;D003924;D000067128;D035683
|
T026;T123;T047;T114
|
36,292,959
|
mixtur ferul acid p coumar acid suppress colorect cancer lncrna pkm mediat aerob glycolysi polyphenol rich food gain popular due potenti benefici effect prevent treatment cancer foxtail millet one import function food rich varieti biolog activ substanc previous studi show ferul acid fa p coumar acid p ca main anticanc compon foxtail millet bran two signific synergist effect present studi clinic applic potenti fa p ca fa p ca evalu vivo vitro fa p ca target gene enrich analysi discov fa p ca associ aerob glycolysi shown fa p ca remodel aerob glycolysi inhibit glycolysi associ lncrna glycolyt rate limit enzym type pyruv kinas pkm moreov pkm express posit correl lncrna interest exogen express lncrna elimin inhibitori effect fa p ca aerob glycolysi collect fa p ca obstruct aerob glycolysi colorect cancer cell via lncrna pkm axi provid nutrit intervent treatment candid colorect cancer
|
D062085;D015179
|
T123;T191;T114
|
36,292,958
|
target deubiquitin enzym dub regul mitophagi via direct indirect interact parkin qualiti control mitochondria critic surviv cell defect pathway requir qualiti control lead sever diseas key qualiti control mechan cell mitophagi function remov damag mitochondria condit various stress defect mitophagi lead number diseas includ neurodegener propos enhanc mitophagi improv cell surviv enhanc neuron function neurodegener extend health lifespan review highlight role deubiquitin enzym dub regul mitophagi summaris current knowledg dub regul mitophagi drug target provid list small molecul inhibitor valuabl tool develop therapeut strategi target mitophagi pathway neurodegener
|
D063306;D044767
|
T126;T116;T043
|
36,292,957
|
effect circumscrib exposur pan aurora kinas inhibitor vx prolifer euploid cell small molecul inhibitor aurora kinas current investig oncolog clinic trial long term effect inhibitor prolifer euploid cell adequ studi examin effect revers pan aurora kinas inhibitor vx p compet human euploid cell circumscrib treatment vx block cytokinesi arrest cell g g like status approxim prolif arrest cell n dna content abnorm nuclei remain cell possess n dna content normal nuclei prolif arrest due activ tumor suppressor rb instead associ rapid induct p p pathway p induct particular evid cell nuclear abnorm independ activ dna damag respons effect correl potent inhibit aurora kinas b releas vx cell normal nuclei robust resum prolifer wherea cell abnorm nuclei underw senesc irrespect nuclear morpholog dna content cell pre treat vx fail grow soft agar form tumor mice find indic intermitt treatment strategi might minim target side effect aurora kinas b aurkb inhibitori therapi strategi allow signific fraction divid normal cell resum prolifer
|
D016159;D009369
|
T123;T191;T116
|
36,292,956
|
microrna mir diabet retinopathi mir biomark contribut diseas progress diabet retinopathi dr chronic diseas associ diabet mellitus lead caus visual impair among work popul us clinic dr diagnos treat vascular complic advers impact neural retina retin vasculatur degener retin neuron microvasculatur manifest diabet retina earli stage dr retin photoreceptor undergo apoptosi short onset diabet contribut retin dysfunct microvascular complic lead vision impair chronic inflamm hallmark diabet contributor cell apoptosi retin photoreceptor major sourc intraocular inflamm contribut vascular abnorm diabet level microrna mir chang plasma vitreous diabet patient mir suggest biomark determin progress diabet ocular diseas includ dr howev mir thorough investig contributor pathogenesi dr among mir mir downregul diabet patient endogen suppressor inflamm apoptosi patholog angiogenesi review mir downstream target contribut diabet associ retin degener patholog angiogenesi dr discuss current effect treatment stop revers diabet caus neural vascular degener retina understand molecular mechan pathogenesi dr may shed light futur develop effect treatment dr diabet associ ocular diseas
|
D003930;D035683;D003920
|
T123;T047;T114
|
36,292,955
|
insight superior hydrophob gentamycin term antibiot deliveri bone tissu bone infect serious problem cure system administr antibiot effect due poor bone vascular therefor mani drug deliveri system investig solv problem one potenti solut deliveri antibiot poli l actid co glycolid plga nanoparticl suspend gellan gum inject hydrogel howev load capac releas kinet system base hydrophil drug eg gentamycin hydrophob polym eg plga may alway satisfi solv problem decid use hydrophob gentamycin obtain ion pair dioctyl sulfosuccin sodium salt aot herein present comparison plga nanoparticl load hydrophob hydrophil gentamycin suspend hydrogel term physicochem properti drug load capac releas profil cytocompat antibacteri properti result show hydrophob gentamycin may combin differ formul hydrophil one superior term encapsul effici drug load releas antibacteri efficaci negat effect nps morpholog hydrogel featur howev cytocompat hydrophob gentamycin might lower consequ extens studi biolog properti provid evalu safe dose
|
D011100;D053758
|
T122;T073;T109
|
36,292,954
|
toward real real space refin atom model high qualiti atom model provid structur inform result refin versus diffract data reciproc space refin versus experiment experiment base map real space refin proper real space refin achiev compar map map calcul atom model similar densiti distribut map limit even inhomogen resolut also calcul sum term known atom imag three dimension peaki function surround fourier rippl atom imag consequ map respect model express analyt function coordin atom displac paramet local resolut work discuss practic feasibl calcul real space refin macromolecular atom model
|
D011487
|
T082
|
36,292,953
|
evolut gene arrang mitogenom ensifera character complet mitogenom schizodactylus jimo gene arrang relat locat gene anoth evolutionari marker mitogenom provid extens inform evolutionari mechan explor evolut gene arrang mitogenom diversifi ensifera sequenc mitogenom uniqu dune cricket speci found china use phylogenet analysi combin known ensiferan mitogenom mitogenom schizodactylus jimo bp circular molecul contain gene identifi eight type gene arrang ensiferan mitogenom gene locat chang ie gene transloc duplic three gene block q nd rrnl rns v nd r n e f phylogenet tree found schizodactylus jimo speci share typic ancient gene arrang type type grylloidea two type type ii iii five type rare scatter phylogenet tree deduc tandem replic random loss model evolutionari mechan gene arrang ensifera select pressur analysi reveal purifi select domin evolut ensiferan mitochondri genom studi suggest gene rearrang ensiferan mitogenom rare accident event
|
D054629;D009987
|
T204;T028
|
36,292,952
|
wnk osr signal regul angiogenesi mediat metastasi toward develop combinatori anti cancer strategi lysin defici protein kinas wnk critic embryon angiogenesi tumor induc angiogenesi howev downstream effector wnk process remain ambigu studi identifi oxid stress respons b osrb upregul endotheli cell embryon tumor induc angiogenesi zebrafish accompani downregul protein phosphatas ppa subunit ppprbb addit wnka osrb upregul two liver cancer transgen fish model tert x p hbx src p rpia ppprbb downregul tert x p furthermor use huvec endotheli cell co cultur hepg hepatoma cell confirm wnk play critic role induct hepatoma cell migrat endotheli cell hepatoma cell moreov overexpress osr rescu reduc cell migrat caus shwnk knockdown huvec cell indic osr downstream wnk endotheli cell promot hepatoma cell migrat overexpress pppra rescu increas cell migrat caus wnk overexpress hepg indic pppra downstream effector hepatoma combinatori treatment wnk inhibitor wnk osr inhibitor rafoxanid plus oligo fucoidan via oral gavag feed hbx src p rpia transgen fish exhibit much signific anticanc efficaci regorafenib advanc hcc import oligo fucoidan reduc cell senesc marker il express furthermor oligo fucoidan reduc increas cell senesc associ galactosidas activ tert transgen fish treat wnk osr inhibitor result reveal wnk osr pppra axi play critic role endotheli hepatoma cell tumor induc angiogenesi promot cancer cell migrat vitro vivo experi uncov molecular mechan wnk downstream effector tumor induc angiogenesi target wnk osr mediat anti angiogenesi anti cancer activ undesir inflamm respons caus inhibit wnk osr attenu combin therapi oligo fucoidan may improv efficaci
|
D006528;D008113
|
T191
|
36,292,951
|
lipid base nanoparticul system ocular deliveri bioactiv anti inflammatori properti complex eye structur physiolog turn ocular drug administr one challeng topic pharmaceut field ocular inflamm one common ophthalm disord topic administr anti inflammatori drug also common use side treatment tissu repair regener difficulti overcom eye barrier physic chemic reduc drug bioavail frequenc administr must increas reach therapeut effect howev caus serious side effect lipid nanoparticl seem great altern ocular drug deliveri compos natur excipi encapsul hydrophil lipophil drug differ sourc uniqu properti excel biocompat safeti adhes allow increas bioavail complianc achiev sustain drug releas also stabl easi produc scale lyophil steril signific alter releas profil stabil lipid nanoparticl show great potenti essenti part new therapeut technolog ophthalmolog deliv synthet natur anti inflammatori drug fact increas interest natur bioactiv anti inflammatori activ use nanoparticl site specif deliveri therefor expect near futur mani studi promot develop new nanomedicin result clinic studi new drug formul
|
D005079;D053758
|
T120;T122;T073
|
36,292,950
|
sensori neuron specif delet tropomyosin receptor kinas trka mice abolish osteoarthr oa pain via ngftrka intervent peripher sensit tropomyosin receptor kinas trkantrk high affin receptor nerv growth factor ngf potent pain mediat ngftrka signal elev synovi sensori neuron distribut joint caus osteoarthr oa pain investig mechan pain transmiss whether peripher sensori neuron link cellular plastic dorsal root ganglia drg critic oa hyperalgesia sensori neuron specif delet trka achiev tamoxifen inject week old trkaflfl navcreert ntrk flfl scnacreert mice oa induc partial medial meniscectomi pmm week old mice oa pain relat behavior analyz week follow comprehens histopatholog examin oa associ joint pain mark improv without cartilag protect sensori neuron specif condit trka knock cko mice allevi hyperalgesia associ suppress ngftrka pathway reduc angiogenesi fibroblast like synovi cell elev pain transmitt drg oa induc mice signific diminish sensori neuron specif trka cko global trka cko mice spinal glial activ brain deriv neurotrop factor bdnf signific increas oa induc mice substanti elimin sensori neuron specif delet result suggest augment ngftrka signal joint synovium peripher sensori neuron facilit pro nocicept central pain sensit
|
D020932;D010003
|
T123;T047;T116
|
36,292,949
|
integr metabolom network pharmacolog deciph latent mechan protopanaxatriol acet acid induc gastric ulcer gastric ulcer gu peptic diseas high morbid mortal rate affect approxim popul throughout world current therapi gu limit high relaps incid side effect therefor novel effect antiulc drug urgent need ginsenosid shown good anti gu effect major intestin bacteri metabolit ginsenosid protopanaxatriol ppt believ activ compon studi evalu anti gu effect ppt rat acet acid induc gu model high h ppt medium ppt dose ppt mgmgday signific reduc ulcer area et il egf sod mda tnf level serum regul ppt dose depend manner also investig mechan anti gu activ ppt base metabolom coupl network pharmacolog strategi result biomark target metabolom pathway identifi play vital role treatment gu ppt valid molecular dock studi demonstr integr analysi metabolom network pharmacolog effect strategi deciph complic mechan natur compound
|
D013276;D036145
|
T121;T047;T109
|
36,292,948
|
research bioengin novel conotoxin milk venom conus obscurus marin cone snail produc one fastest prey strike anim kingdom inject high efficaci venom often caus prey paralysi death within second snail hundr conotoxin serv sourc discov util novel analges peptid therapeut studi discov isol synthes novel conotoxin deriv milk venom conus obscurus conotoxin oi identifi presenc conotoxin si like sequenc previous found venom conus striatus five synthet analog nativ conotoxin oi generat analog incorpor singl residu doubl residu mutat three synthet post translat modif ptms synthet incorpor analog n termin truncat prolin hydroxyl tryptophan bromin nativ conotoxin oi demonstr nanomolar potenc poecilia reticulata homo sapien muscl type nicotin acetylcholin receptor nachr isoform moreov synthet pk conotoxin oi display enhanc potenc bioassay rang ld ic fold increas compar bioactiv success incorpor ptms retent potenc nachr isoform select ultim push new boundari peptid bioengin generat novel conotoxin like sequenc
|
D052078;D020916;D011978
|
T123;T116;T192;T131;T204
|
36,292,947
|
amyloid lipid metabol basal cholinerg system therapeut alzheim diseas presenc insolubl aggreg amyloid form neurit plaqu nps one main featur defin alzheim diseas studi suggest accumul peptid brain signific contribut extens neuron loss furthermor content distribut cholesterol membran shown import effect product subsequ accumul peptid plasma membran contribut dysfunct neuron death monomer form membran bound peptid undergo sever conform chang rang oligomer form beta sheet structur present differ level toxic peptid intern particular receptor trigger chang tau phosphoryl alter cognit function dysfunct cholinerg system goal review summar current knowledg role lipid alzheim diseas relationship basal cholinerg system well potenti diseas modifi therapi
|
D016229;D000544
|
T047;T116;T048
|
36,292,946
|
possibl involv upregul np express mediat activ aryl hydrocarbon receptor mammospher mainten cancer stem cell cscs contribut drug resist recurr metastasi breast cancer recent demonstr overexpress increas mammospher format via activ aryl hydrocarbon receptor ahr studi object identifi mechan under mammospher mainten mediat signal activ ahr compar chromatin structur ahr knockout ahrko overexpress mcf cell wild type cell subsequ identifi tp stem factor potenti target gene ahr np mrna protein level higher cell ahrko cell activ herher signal heregulin treatment increas np mrna level induct decreas ahr knockdown cell result chromatin immunoprecipit assay reveal interact ahr intron region tp encod np luciferas report gene assay intron region tp show ahr express increas report activ collect find suggest activ ahr upregul np express signal cascad involv csc mainten express breast cancer
|
D018336;D001943
|
T191;T116;T192
|
36,292,945
|
efdn transgen mice tool evalu ef therapeut target neuropatholog brain age ef initi describ transcript factor key function regul cell quiescenc nevertheless number recent studi establish ef also play relev role cell tissu homeostasi well tissu regener non canon function ef also act cytoplasm abl interact mani homeostat synapt regul sinc ef express nervous system may fulfil crucial role brain function homeostasi promis multifactori target neurodegen diseas brain age regul ef complex chemic modifi acetyl present evid brain well methyl phosphoryl phosphoryl ef within conserv threonin motif induc cell cycl entri neuron domin negat form ef efdn conserv threonin substitut alanin shown act multifactori therapeut agent alzheim diseas ad generat transgen mice neuron express efdn recent shown use mous strain express efdn xfad mice known murin model ad improv cognit function reduc neuron tetraploid induc transcript program consist modul amyloid peptid proteostasi brain homeostasi recoveri xfadefdn mice also show reduc microgliosi astrogliosi cerebr cortex hippocampus month age analyz immun respons year old xfadefdn mice conclud reduc microgliosi astrogliosi maintain late stage addit express efdn also reduc age associ microgliosi wild type mice thus stress role brain homeostat agent conclud efdn transgen mice repres promis tool evalu ef therapeut target neuropatholog brain age
|
D005911;D000544
|
T047;T046;T020;T048
|
36,292,944
|
molecular research amyotroph later sclerosi amyotroph later sclerosi al rare progress lethal degen diseas motor neuron treatment current avail
|
D000690
|
T047
|
36,292,943
|
sleep modul alcohol toxic drosophila alcohol abus signific public health problem consider research shown alcohol use affect sleep littl known role sleep depriv alcohol toxic investig sleep factor modul alcohol toxic use drosophila melanogast model studi sleep alcohol age follow h sleep depriv use paradigm similar affect male femal induc rebound sleep fli given bing like alcohol exposur sleep depriv increas mortal sex depend differ sleep depriv also abolish function toler measur h initi alcohol exposur although effect alcohol absorb clearanc investig effect chronic sleep depriv use mutant decreas sleep insomniac insulin like peptid find increas alcohol mortal furthermor investig whether pharmacolog induc sleep prior alcohol exposur use gaba receptor agonist tetrahydroisoxazolo c pyridin ol thip mitig effect alcohol toxic middl age fli fli environment disrupt circadian clock fli short sleep pharmacolog increas sleep prior alcohol exposur decreas alcohol induc mortal thus sleep prior bing like alcohol exposur affect alcohol induc mortal even vulner group age fli circadian dysfunct
|
D029721;D061385
|
T123;T121;T116
|
36,292,942
|
oxygen glucos depriv promot fibroblast senesc collagen express via il cell senesc one import form injuri induc cardiovascular ischem diseas fibroblast import particip tissu repair ischem injuri main sourc il secret howev role oxygen glucos depriv ogd il promot fibroblast senesc regulatori mechan remain unclear studi select niht l fibroblast cell line research object found ogd could induc express p p p collagen fibroblast condit ogd il interven fibroblast senesc collagen express chang studi found chang kynurenin kyn metabol relat age diseas indoleamin dioxygenas ido key rate limit enzym kyn metabol pathway found kyn secret decreas ogd increas fibroblast senesc inhibit il promot ido increas kyn secret result suggest ogd may promot fibroblast senesc collagen express via il inhibit idokyn metabol pathway therefor reveal mechan ogd promot fibroblast senesc could provid effect theoret basi clinic treatment age relat ischem diseas
|
D007737;D050503
|
T123;T126;T116
|
36,292,941
|
transcriptom metabolom analysi pseudomona resist versus suscept arabidopsi access access one plant speci may show signific differ level suscept stress arabidopsi thaliana access col c differ signific resist pathogen pseudomona syringa pv tomato pst help unravel under mechan contribut natur occur varianc resist pst analyz chang transcript compound primari secondari metabol col c differ time point infect pst result show differ resist col c main involv mechan salicyl acid depend system acquir resist respons jasmon acid depend mechan share two access addit arginin metabol differenti activ biosynthesi pathway aliphat glucosinol indol glucosinol may also contribut resist thus studi highlight differ defens respons strategi util differ genotyp
|
D017360;D029681
|
T116;T002
|
36,292,940
|
next step prader willi syndrom research relationship genotyp phenotyp articl review know phenotyp genotyp prader willi syndrom hypothes two possibl path phenotyp genotyp suggest research may strengthen case one hypothes
|
D011218
|
T047
|
36,292,939
|
chang farnesen phenol metabol express associ gene develop superfici scald two distinct pear cultivar superfici scald postharvest physiolog disord occur pear cold storag studi superfici scald index farnesen oxid product conjug trienol ctol phenol content express relat gene investig two differ pear cultivar wujiuxiang pyrus communi l yali pyrus bretschneideri r follow day cold storag c follow day shelf life c result indic superfici scald occur day cold storag becam sever shelf life wujiuxiang pear wherea scald observ yali farnesen level increas rapid first decreas ctol content increas signific wujiuxiang compar yali express level gene involv farnesen ctol metabol hmgr hmgr gstu gpx gpx well phenol synthesi pal pal ch cl ch anr peel signific regul onset superfici scald addit relat conduct content catechin epicatechin higher express level laccas gene lac signific increas develop superfici scald lower content chlorogen acid arbutin isorhamnetin glucosid well lower express level phenol synthesi relat gene ch polyphenol oxidas gene ppo ppo notic wujiuxiang compar yali result indic onset progress superfici scald associ accumul ctol cell membran breakdown higher catechin epicatechin rutin content well express associ gene peel pear fruit
|
D031989;D002392
|
T168;T121;T002;T109
|
36,292,938
|
multi omic reveal mechan partial modul covid dysregul glucocorticoid treatment treatment covid infect improv dramat sinc begin pandem glucocorticoid key tool improv mortal rate uk nation institut health care excel guidanc treatment target requir oxygen supplement howev interact glucocorticoid covid complet understood work multi omic analysi inpati recruit particip perform quantit metabolom use target liquid chromatographi mass spectrometri data independ acquisit proteom omic dataset analys statist signific featur pathway differenti particip whose treatment regimen includ glucocorticoid metabolom differ glucocorticoid treat patient includ modul cortisol bile acid concentr serum allevi serum dyslipidemia increas amino acid concentr includ tyrosin arginin glucocorticoid treat cohort relat untreat cohort proteom pathway analysi indic neutrophil platelet degranul influenc glucocorticoid treatment result keep key role platelet associ pathway neutrophil covid pathogenesi provid opportun understand glucocorticoid action find also howev highlight glucocorticoid fulli effect across wide rang omic dysregul caus covid infect
|
D005938;D000086382
|
T039;T067;T109;T125;T047
|
36,292,937
|
insight muscl contract deriv effect small molecular actomyosin modul compound bottom mechanokinet model predict ensembl function actin myosin base paramet valu deriv studi use isol protein general use eg analyz diseas effect model must also abl predict ensembl function actomyosin interact kinet modifi differ normal test capabl model recent shown predict sever physiolog phenomena along effect small molecular compound blebbistatin demonstr model also qualit predict effect well character drug well vari concentr mgatp howev effect one compound amrinon well account quantit therefor systemat vari key model paramet address issu lead increas amplitud second sub stroke power stroke nm nm unchang first sub stroke nm effect cross bridg attach rate doubl addit better account effect amrinon modifi model also account well normal physiolog ensembl function moreov mont carlo simul base version model use evalu forc veloc data small myosin ensembl discuss find relat key aspect actin myosin oper mechan caus non hyperbol shape forc veloc relationship high load also discuss remain limit model includ uncertainti whether cross bridg elast linear capabl account contractil properti small actomyosin ensembl lt myosin head mechan requir higher cross bridg attach rate shorten compar isometr contract
|
D000205;D000199
|
T123;T116
|
36,292,936
|
import heparan sulfat proteoglycan pancreat islet cell cell islet langerhan pancrea secret insulin respons glucos concentr blood pancreat cell damag diabet develop glucos intoler caus insuffici insulin secret high molecular weight polysaccharid heparin heparan sulfat hs proteoglycan hs degrad enzym heparinas particip protect mainten enhanc function pancreat islet cell demand studi glycobiolog within field diabet research increas review introduc role complex glycoconjug contain high molecular weight polysaccharid degrad enzym pancreat islet cell includ obtain studi conduct us earlier addit perspect glycobiolog studi propos possibl applic diabet medicin
|
D019812;D007515
|
T123;T023;T116
|
36,292,935
|
discoveri dual senp senp inhibitor sumoyl revers post translat modif ptm involv coval attach small ubiquitin relat modifi sumo protein substrat protein dysregul sumoyl desumoyl result cellular malfunct link various diseas cancer sentrin specif proteas senp identifi matur sumo deconjug sumo substrat protein henc promis target tackl dysregul sumoyl process herein report discoveri novel protein protein interact ppi inhibitor senp sumo virtual screen subsequ medicin chemistri optim hit molecul optim inhibitor zhawoc show ic valu senp senp photo affin probe senp target valid novel senp inhibitor repres new valuabl tool studi sumoyl process senp associ develop small molecul base treatment option
|
D025841;D058207
|
T123;T116;T044
|
36,292,934
|
explor mysteri tetrahydrobiopterin synthet defect lethal mutant leml birth death silkworm bombyx mori tetrahydrobiopterin bh vital coenzym sever enzym involv divers enzymat reaction anim bh defici lead metabol neurolog disord due dysfunct metabol silkworm natur homozyg mutant leml key enzym sepiapterin reductas bmspr de novo synthesi pathway bh inactiv result sever defici bh synthesi howev known leml larva surviv second instar stage pathway lead death bh defici quantifi bh found fertil egg contain larg amount bh transfer mother offspr maintain normal develop embryo first instar subsequ investig multipl pathway bh involv cofactor result show bh defici silkworm block melanin synthesi pathway caus insuffici degre epiderm sclerosi disord tyrosin metabol damag mitochondria hand bh defici led uncoupl nitric oxid synthas bmnos reduc product signific reduc fat fat bodi catalyz phospholipas result impair immun system meanwhil uncoupl bmnos increas content damag dna caus apoptosi bodi cell taken togeth bh critic life death leml mutant studi lay foundat explor lepidopteran insect provid import basi treatment human bh defici relat diseas
|
D012831;D010661
|
T047;T204
|
36,292,933
|
epigenet chang chromatin reorgan brain function lesson fear memori ensembl alzheim diseas healthi brain function mammal requir continu fine tune gene express accumul evid last three decad demonstr epigenet mechan dynam chang chromatin organ critic compon control gene transcript neural cell recent genom wide analys show regul brain gene requir contribut promot long distanc enhanc element must function interact upregul gene express respons physiolog cue henc deep comprehens mechan mediat enhanc promot interact epi critic understand process associ learn memori recal moreov onset progress sever neurodegen diseas neurolog alter found strong associ chang compon support andor modul dynam epi overview relev discoveri field support role chromatin organ specif epigenet mechan control gene transcript neural cell healthi mice subject fear condit paradigm relev model studi memori ensembl addit special consider dedic revis recent result generat investig work anim model human postmortem brain tissu address chang epigenom chromatin architectur contribut transcript dysregul alzheim diseas wide studi neurodegen diseas also discuss recent develop potenti new therapeut strategi involv epigenet edit small chromatin modifi molecul epidrug
|
D000544;D019636
|
T047;T048
|
36,292,932
|
design cyclic peptid base nanospher deliveri sirna recent year cyclic peptid attract much attent due chemic enzymat stabil low toxic easi modif general self assembl nanostructur cyclic peptid tend form nanotub cyclic stack manner hydrogen bond howev studi explor assembl strategi scarc context propos new assembl strategi base cyclic peptid coval self assembl cyclic peptid dpdpdp ration design use build block construct new assembl cyclo dp structur unit diamino n methyldiethylamin linker posit charg nanospher cp ns base cyclo dp success construct coval self assembl assess size morpholog scan electron microscopi sem tem dls cp ns found strong posit charg could bind sirna electrostat interact confoc microscopi analysi cell viabil assay show cp ns high cellular intern effici low cytotox import real time polymeras chain reaction pcr flow cytometri analys indic cp ns sirna complex potent inhibit gene express promot tumor cell apoptosi result suggest cp ns may potenti sirna carrier gene therapi
|
D054118;D043942;D049329
|
T073
|
36,292,931
|
flavonol quercitrin hinder gsk activ potenti wnt catenin signal pathway wnt catenin signal pathway dictat cell prolifer differenti embryon develop tissu homeostasi deregul associ mani patholog condit includ neurodegen diseas frequent downregul lack effici treatment diseas includ alzheim diseas ad make wnt signal attract target therapi interest novel wnt signal activ compound less frequent describ inhibitor turn quest novel posit modul even appeal sens natur compound outstand sourc potenti drug lead combin differ experiment model cell base approach neuron cultur assay rodent behavior test xenopus laevi phenotyp analysi character quercitrin natur compound novel wnt signal potenti find quercitrin potenti signal concentr depend manner increas occurr xenopus secondari axi phenotyp mediat xwnt inject use gsk biosensor describ quercitrin impair gsk activ increas phosphoryl gsk level treatment xav inhibitor downstream gsk impair quercitrin mediat effect next show quercitrin potenti wnta synaptogen effect hippocamp neuron cultur block xav quercitrin treatment also rescu hippocamp synaps loss induc intracerebroventricular inject amyloid oligom ao mice final quercitrin rescu ao mediat memori impair prevent xav thus studi uncov novel function quercitrin wnt catenin signal potenti describ mechan action open new avenu ad treatment
|
D019636;D000544
|
T047;T048
|
36,292,930
|
melatonin enhanc drought toler rice seedl modul antioxid system osmoregul correspond gene express rice third largest food crop world especi asia product various region affect differ degre drought stress melatonin mt novel growth regul play essenti role enhanc stress resist crop nevertheless under mechan melatonin help mitig drought damag rice remain unclear therefor present studi rice seedl pretreat melatonin stress drought water potenti mpa rice seedl subsequ examin phenotyp physiolog molecular properti includ metabolit content enzym activ correspond gene express level find demonstr drought stress induc increas malondialdehyd mda level lipoxygenas lox activ reactiv oxygen speci ros eg h rice seedl howev melatonin applic signific reduc lox activ mda ros content product rate h content decreas respect activ express alm ospox oscatc osapx increas activ antioxid enzym superoxid dismutas sod peroxidas pod catalas cat ascorb peroxidas apx respect meanwhil melatonin pretreat enhanc prolin fructos sucros content induc ospc ossus ossp gene express level moreov melatonin pretreat consider regul express level melatonin synthesi gene tdc asmt drought stress fold fold approxim improv reflect increas relat water content rwc root shoot ratio drought stress rice seedl receiv melatonin applic consequ melatonin consider reduc advers effect drought stress rice seedl improv rice abil toler drought primarili boost endogen antioxid enzym osmoregul abil
|
D012275;D008550
|
T121;T109;T168;T125;T002
|
36,292,929
|
physiolog transcriptom analys uncov reason inhibit photosynthesi phosphat defici cucumi melo l phosphat pi defici common phenomenon agricultur product limit plant growth recent work show long term pi defici caus inhibit photosynthesi ineffici electron transport howev under mechan still unknown studi use physiolog histochem transcriptom method investig effect low pi stress photosynthet gas exchang paramet cell membran lipid chloroplast ultrastructur transcript regul key gene melon seedl result show pi defici signific downregul express aquaporin gene induc increas aba level reduc water content free water content melon leav caus physiolog drought melon leav therefor gas exchang disturb pi defici also reduc phospholipid content leaf cell membran caus peroxid membran lipid destroy ultrastructur chloroplast transcriptom analysi show differenti express gene deg upregul downregul pi defici leav go kegg enrich analysi show deg signific enrich chloroplast thylakoid membran composit go photosynthesi antenna protein map photosynthesi pathway map downregul pi defici indic pi defici regul photosynthesi relat gene transcript level therebi affect histochem properti physiolog function consequ caus reduc light assimil abil photosynthesi effici enrich mechan photosynthesi inhibit pi defici
|
D028463
|
T168;T002
|
36,292,928
|
ferment angelica tenussima aspergillus oryza improv skin barrier properti moistur anti inflammatori respons angelica tenussima root use tradit medicin asia recent anti melanogen anti photogen effect ferment tenuissima root fat identifi howev inform anti atop dermat action fat limit thus purpos studi determin applic fat ad identifi efficaci fat skin barrier inflammatori respons main pathogenesi ad express level skin barrier compon product inflammatori mediat human keratinocyt mous macrophag cell measur quantit rt pcr elisa fat upregul express skin barrier compon filaggrin involucrin loricurin sptlc inhibit secret inflammatori chemokin tarc hacat cell furthermor suppress pro inflammatori cytokin il tnf nitric oxid product lps induc raw cell addit ligustilid increas filaggrin sptlc also lower pro inflammatori mediat increas atop environ fat result mean ligustilid one activ ingredi deriv fat amelior ad least part promot skin barrier format downregul inflammatori mediat result suggest fat potenti function cosmet materi care manag ad
|
D014409;D001236
|
T129;T004;T116
|
36,292,927
|
lc ms base lipidom depict phosphatidylethanolamin biomark tnbc mda mb ntnbc mcf cell breast cancer bc first malign neoplasm women high death rate despit earli diagnos treatment advanc signific differ exist common bc tripl negat breast cancer tnbc tnbc present molecular differ lack express estrogen receptor er progesteron receptor pr protein make cancer poor clinic prognost lack clear strategi treatment howev grow evid point metabol dysregul anoth differenti process stage type bc therefor studi crucial hallmark could identifi new therapeut target treat aggress form bc differ induc vitro explor metabol behavior mcf cell ntnbc mda mb tnbc cell lipidom base lc ms result show signific differ lipid regul phosphatidylethanolamin could associ aggress difficulti treatment tnbc
|
D064726
|
T191
|
36,292,926
|
microrna milk cell plasma lipid fraction human milk abzym catalyz hydrolysi human milk provid neonat various compon ensur newborn growth includ protect bacteri viral infect neonat biolog function mani breast milk compon differ compar function bodi fluid healthi adult catalyt antibodi abzym hydrolyz peptid protein dnas rnas oligosaccharid detect blood sera autoimmun patient also human milk non code microrna nucleotid intra extracellular molecul differ human fluid mirna possess mani differ biolog function includ regul sever hundr gene five mir p mir c p mir p mir b p let f p previous found milk high concentr determin relat number mirna copi mg analyz cell lipid fraction plasma human milk sampl relat amount microrna decreas follow order cell lipid fraction gt plasma igg siga isol milk plasma activ hydrolysi five microrna compar general siga demonstr higher mirna hydrolyz activ igg antibodi hydrolysi five microrna siga igg site specif relat activ microrna hydrolysi depend milk prepar correl coeffici content five rnas milk plasma relat activ siga compar igg hydrolys strong depend individu microrna chang thus shown milk contain specif antibodi abzym hydrolyz microrna specif human milk
|
D017151;D035683
|
T123;T116;T114
|
36,292,925
|
neutrophil n n subset possibl associ periodont scope review periodont chronic non communic diseas caus dysbiot chang affect subgingiv microbiota periodont neutrophil play central role initi recognit bacteria number increas appear first sign periodont inflamm recent evid led proposit neutrophil also function polar determin select activ pattern relat differ diseas two well defin neutrophil phenotyp describ pro inflammatori n subset suppressor n subset date establish whether differ neutrophil subtyp play role pathogenesi periodont thus scope review aim determin whether evid suggest neutrophil present periodont tissu associ certain phenotyp research question popul concept context sought identifi origin articl human detect presenc neutrophil periodont tissu peopl affect periodont base search strategi found studi remov paper abstract relat outcom measur elig criteria articl includ qualit analysi sever studi identifi presenc differ neutrophil subset specif naiv pro para inflammatori hyper reactiv hyper activ high low respond phenotyp exist evid demonstr presenc pro inflammatori hyper reactiv high respond neutrophil periodont tissu affect periodont evid demonstr presenc n n phenotyp periodont tissu periodont howev exist pro inflammatori phenotyp increas netosi degranul increas product pro inflammatori cytokin could suggest n phenotyp
|
D009504;D010518
|
T047;T025
|
36,292,924
|
effect exosom deriv adipos deriv mesenchym stem cell pyroptosi regener injur liver although accumul evid indic exosom posit therapeut effect hepat ischemia reperfus injuri hiri studi focus allevi liver injuri exosom deriv adipos deriv mesenchym stem cell adsc exo base inhibit cell pyroptosi yet report exosom contain differ kind biolog activ substanc protein lipid mrnas mirna signal molecul molecul wide involv cell cell communic cell signal transmiss prolifer migrat apoptosi therefor investig posit effect exert adsc exo hepat ischemia reperfus partial resect injuri rat studi found post oper tail vein inject adsc exo could effect inhibit express pyroptosi relat factor nlrp asc caspas gsdmd n promot express regener relat factor cyclin vegf moreov found cellular activ associ nf b wnt catenin signal pathway accord result adsc adsc exo reduc pyroptosi injur liver promot express factor relat liver regener inhibit nf b pathway activ wnt catenin pathway howev although adipos deriv mesenchym stem cell adsc transplant reduc liver injuri lead signific increas pyroptosi relat protein gsdmd n express conclus studi show adsc exo uniqu advantag signific cell free therapi replac stem cell still broad research prospect clinic diagnosi treatment liver injuri
|
D055354;D059630;D035683
|
T026;T123;T025;T114
|
36,292,923
|
diclofenac sensit signet ring cell gastric carcinoma cell cisplatin activ autophagi inhibit surviv signal pathway gastric cancer one highest incid rate cancer worldwid also contribut increas drug resist among patient clinic practic herein investig role diclofenac dcf sensit cisplatin resist signet ring cell gastric carcinoma cell srcgc non toxic concentr dcf signific augment cisplatin induc cell death cisplatin resist srcgc cell katoddp cisplatin sensit srcgc cell katoiii consist concomit treatment dcf cisplatin signific enhanc autophag cell death due overproduct intracellular reactiv oxygen speci ros molecular level induct ros associ reduct antioxid enzym express inhibit nuclear factor erythroid relat factor nrf activ moreov combin dcf cisplatin also inhibit express surviv protein includ bcl bcl xl ciap cyclin katoddp cell compar cisplatin alon due least part reduc mapk akt nf b ap stat activ taken togeth result suggest dcf potenti anticanc effect cisplatin srcgc via regener intracellular ros turn promot cell death autophagi mechan potenti modul cell surviv signal transduct pathway
|
D013274;D018279
|
T191
|
36,292,922
|
focus pd pd l therapeut target ovarian cancer ovarian cancer consid one aggress deadliest gynecolog malign worldwid unfortun therapeut method consid gold standard moment associ frequent recurr surviv ovarian cancer associ presenc high number intra tumor infiltr lymphocyt til therefor immunomodul consid import role cancer treatment immun checkpoint inhibitor may use restor cell mediat antitumor immun howev data present literatur suffici allow identif select patient realli respond immunotherapi among ovarian cancer although studi favor result prospect trial need sens review focus current futur perspect pd l blockad ovarian cancer analyz import immun checkpoint inhibitor use aim achiev optim clinic outcom futur studi trial need maxim efficaci immun checkpoint blockad therapi ovarian cancer well cancer general
|
D060890;D010051
|
T129;T191;T116
|
36,292,921
|
evolutionari origin metabol reprogram cancer metabol chang facilit tumor growth one hallmark cancer chang specif tumor also take place physiolog growth tissu inde cellular tissu mechan present tumor physiolog counterpart repair tissu lesion wound heal molecular mechan acquir metazoan evolut first elimin infect tissu injuri enter effect regen phase cancer could consid phenomenon antagonist pleiotropi gene involv effect tissu repair cancer tissu repair complex trait share mani intermedi phenotyp molecular cellular tissu level integr within system biolog structur complex trait influenc multitud common gene weak effect polygen compon complex trait main unknown make part miss herit tri integr differ perspect point view metabol chang observ cancer
|
D009369
|
T191
|
36,292,920
|
metabolom driven mine metabolit resourc applic prospect improv veget crop veget crop possess promin nutri metabolit pool contribut crop perform field also offer nutrit secur human pursuit identifi quantifi function character cellular metabolom pool biomolecul separ technolog data acquisit platform chemic librari bioinformat tool databas visual techniqu come play signific role high throughput metabolom unravel structur divers nutrit rich metabolit entangl interact veget plant help link identifi phytometabolit uniqu phenotyp trait nutri function charact defens mechan crop product studi explor mine divers metabolit local cellular metabol pathway classifi function biomolecul establish linkag metabol flux genom regul use comprehens metabolom deciph plant perform environ discuss exemplari report cover implic metabolom address metabol chang veget plant crop domest stage depend growth fruit develop nutri metabol capabl climat impact plant microb pest interact anthropogen activ effort lead identifi biomark metabolit candid protein gene respons plant health defens mechan nutri rich crop produc document insight metabolit qtl mqtl driven genet architectur molecular breed veget crop revolution develop better nutrit capabl improv toler diseasespest enhanc climat resili plant
|
D014675;D054852
|
T168;T170
|
36,292,919
|
jatrorrhizin improv endotheli function diabet obes suppress endoplasm reticulum stress jatrorrhizin jat one major bioactiv protoberberin alkaloid found rhizoma coptidi hypoglycem hypolipidem potenti studi aim evalu vasoprotect effect jat diabet obes under mechan involv mous aorta carotid arteri human umbil cord vein endotheli cell huvec treat risk factor high glucos tunicamycin without jat ex vivo vitro furthermor aorta obtain mice chronic treatment control diet induc obes dio mice fed high fat diet kcal fat week dio mice oral administ jat mgkgday last week high glucos endoplasm reticulum er stress induc tunicamycin impair acetylcholin induc endothelium depend relax edr mous aorta induc oxid stress carotid arteri huvec downregul phosphoryl akt ser eno ser enhanc er stress mous aorta huvec impair revers cotreat jat jat increas releas high glucos treat mous aorta huvec addit chronic jat treatment restor endotheli function edr compar control increas akteno phosphoryl attenu er stress oxid stress aorta dio mice blood pressur glucos sensit fatti liver morpholog chang well plasma level aspart aminotransferas ast alanin aminotransferas alt plasma lipid profil also normal jat treatment collect data may first reveal vasoprotect effect jat amelior endotheli dysfunct diabet obes enhanc akteno pathway bioavail well suppress er stress oxid stress
|
D004365;D003920
|
T123;T047;T121
|
36,292,918
|
cdv altern splice form cd promot pancreat cancer progress pancreat cancer one lethal malign tumor howev molecular mechan respons progress littl known studi aim understand regulatori role cdv pancreat cancer kaplan meier analysi perform reveal correl cdcdv express prognosi pancreat cancer patient cdv uaf knock use shrnas prolifer migrat invas stem two pancreat cell line bxpc aspc examin express cdv cancer associ marker activ akt signal detect qrt pcr western blot cd cdv express level associ poor prognosi pancreat cancer patient interest express cdv instead cd great increas tumor tissu cdv knockdown inhibit prolifer migrat invas stem cancer cell cdv splice regul uaf downregul uaf enhanc cdv express promot pancreat cancer progress cdv import cancer promot factor may serv potenti candid pancreat cancer intervent
|
D051057;D010190
|
T191;T126;T116
|
36,292,917
|
develop two layer hybrid scaffold base oxid polyvinyl alcohol bioactiv chitosan spong tissu engin purpos oxid polyvinyl alcohol oxpva new polym fabric nerv conduit ncs look oxpva devic optim coupl natur sheath may boost bioactiv thus oxpvachitosan spong chs hybrid scaffold investig predict vivo behaviour two layer ncs encourag interact cell chs function self assembl peptid sap eak withoutwith laminin deriv sequenc ikvav yigsr thus chs hybrid scaffold character mechan properti ultrastructur scan electron microscopi sem bioactiv biocompat regard mechan analysi peptid free chs show highest valu compress modulus maximum stress howev among eak group chseak show signific higher maximum stress found chseak ikvav chseak yigsr consid ultrastructur micropor interconnect tighter oxpvach eak group other scaffold induc sh syy cell adhesionprolifer signific differ day higher total cell number oxpvachseak scaffold accord sem scaffold elicit slight inflamm day subcutan implant balbc mice prove biocompat chs poros eak featur neuro friend attitud share ikvavyigsr motif may confer oxpva certain bioactiv lay basi futur appeal ncs
|
D048271;D009447
|
T121;T191;T109
|
36,292,916
|
uncov novel featur pc locus horn develop gene edit holstein cattl rna sequenc analysi poll celtic pc mutat locus genet simpl singl mutat best choic breed poll cattl use gene edit howev mechan pc locus regul horn develop unclear use gene edit somat cell nuclear transfer embryo transfer obtain poll holstein fetal bovin gestat time day homozyg pc insert gene edit holstein fetal bovin eh wild type day holstein fetal bovin wh control hematoxylin eosin stain result show compar wh eh horn bud white keratin project vacuol keratinocyt thick nerv bundl dermal tissu furthermor dna sequenc result show pc locus homozyg insert fetal bovin genom total differenti express gene identifi transcriptom sequenc analysi enrich analysi protein interact analysi result differenti express gene show abund gene chang pc insert associ adhes molecul regul actin express cytoskelet deform keratin express keratin also note result contain sever gene report associ develop horn trait rxfp twist studi identifi chang first time summar result suggest pc mutant locus may inhibit neural crest cell emt generat keratin express lead failur neural crest cell migrat keratin horn bud tissu regul product poll phenotyp
|
D006733
|
T023
|
36,292,915
|
intron depend independ pseudouridyl precursor trna contain atyp intron cyanidioschyzon merola eukaryot precursor trnas pre trnas often intron posit anticodon loop howev atyp intron found eukaryot archaea earli diverg red alga cyanidioschyzon merola trna ile uau gene contain three intron code region locat anticodon arm studi focus relationship intron remov format pseudouridin one univers modifi nucleosid report yeast pus multipl site specif enzym synthes trna ile uau intron depend manner unexpect biochem experi show c merola ortholog pus pseudouridyl intronless trna ile uau modif posit determin target pus pus yeast furthermor unlik yeast pus cmpus mediat modif posit andor specif intron contain pre trna ile uau variant cmpus confirm singl site specif enzym convert u similar manner yeast pus cmpus catalyz pseudouridin format pre trnas contain intron arm
|
D011560;D000461
|
T123;T002;T114
|
36,292,804
|
theori design strategi support implement genom nephrolog background genom test increas util clinic tool howev integr nephrolog remain limit purpos studi identifi barrier priorit intervent widespread implement genom nephrolog method qualit semi structur interview conduct australian adult nephrologist determin perspect intervent model care support implement genom nephrolog interview guid valid theoret framework implement genom medicin consolid framework implement research cfir result nephrologist hospit dedic multidisciplinari kidney genet servic practic public healthcar system n larg number earli career n genom experi n top three prefer intervent increas fund access genom champion educ train intervent barrier report use cfirexpert recommend implement chang match tool generat theori inform approach prefer model servic deliveri multidisciplinari kidney genet clinic conclus studi identifi surmount barrier practic intervent implement genom nephrolog multidisciplinari kidney genet clinic identifi prefer model care integr genom educ nephrolog train secur fund test counsel along identif genom champion pursu health servic broad
|
D009398
|
T091
|
36,292,803
|
genom wide identif character oat avena sativa l wrki transcript factor famili wrki famili wide involv regul plant growth stress respons one largest gene famili relat plant environment adapt howev systemat studi wrki famili oat avena sativa l conduct date recent publish complet genom sequenc oat enabl systemat analysi aswrki base genom wide studi oat identifi aswrki uneven distribut across chromosom phylogenet tree wrki domain divid gene three group ii iii also analyz gene duplic event identifi total gene pair show strong purifi select evolutionari process surpris almost gene evolv complet subgenom differenti hexaploid oat studi function analysi indic aswrki wide involv various biolog process notabl express pattern aswrki gene reveal respons aswrki affect stress level time conclus studi provid refer analysi role wrki transcript factor speci evolut function differenti
|
D014157;D018554
|
T123;T116;T002
|
36,292,802
|
advanc novel anim vitamin c biosynthesi pathway role prokaryot base infer understand origin vitamin c vc essenti nutrient requir optim function develop mani organ vc studi mani decad still today character function dynam scientif field main commerci therapeut applic review discuss compar way increas evid altern vc synthesi pathway insect nematod potenti myo inositol possibl substrat metabol process metazoan methodolog approach may use futur character vc synthesi pathway caenorhabd elegan drosophila melanogast discuss also summar current distribut eukaryot aldonolacton oxidoreductas gene lineag highlight ad valu studi prokaryot speci like abl synthes vc character novel vc synthesi pathway infer complex evolutionari histori pathway work may help improv industri product vc
|
D004331;D001205
|
T121;T127;T204;T109
|
36,292,801
|
integr lncrnas protein code gene patholog imag detect metastat melanoma melanoma lethal skin diseas develop mole studi aim integr multimod data predict metastat melanoma high aggress difficult treat propos ensembleskcm method evalu predict perform long noncod rnas lncrnas protein code messeng gene mrnas patholog imag imag metastat melanoma featur select use screen metastat biomark lncrna mrna dataset integr ensembleskcm model built base weight result lncrna mrna imag base model ensembleskcm achiev predict accuraci metastat melanoma outperform singl modal predict model base lncrna mrna imag data experiment data suggest import integr complementari inform three data modal wgcna use analyz relationship molecular level featur imag featur result show connect anoth cohort use valid predict
|
D062085;D008545;D016609
|
T123;T191;T114
|
36,292,800
|
light chain domain especi c terminus receptor bind domain botulinum neurotoxin bont hotspot amino acid variabl toxin type divers botulinum neurotoxin bont potent toxin world produc dozen strain within sever clostridi speci toxin produc caus botul flaccid paralysi human anim seven establish serolog differ type subtyp bont among divers known toxin toxin structur function physiolog effect neural cell anim host along divers subject numer studi howev mani gap remain knowledg bont toxin speci produc one gap involv distribut extent variabl along full length gene protein well domain subdomain studi perform extens analysi avail uniqu bont encod gene product investig divers evolut result indic nucleotid variabl almost uniform distribut along entir length gene amino acid variabl found differ concentr along protein light chain lc domain especi c terminus receptor bind domain h cc two region protein thus identifi main sourc toxin type differenti consequ toxin versatil bind differ receptor isoform act upon differ substrat thus infect differ host
|
D001905;D001906
|
T121;T116;T131;T037;T047
|
36,292,799
|
supervis machin learn enabl geospati microbi proven recent increas public avail metagenom dataset geospati metadata made possibl determin locat specif microbi fingerprint around world fingerprint use compar microbi nich environment research well applic within forens scienc public health determin region specif environment metagenom examin shotgun sequenc sampl metasub consortium dataset extens public collect urban microbiom span differ citi countri contin abl identifi citi specif microbi fingerprint use supervis machin learn sml taxonom classif also compar perform ten sml classifi evalu five algorithm highest accuraci citi continent accuraci rang respect thereaft use result develop cassandra random forest base classifi identifi bioindic speci aid fingerprint infer higher order microbi interact site test cassandra algorithm tara ocean dataset largest collect marin base microbi genom classifi ocean sampl locat accuraci result code show util sml method cassandra identifi bioindic speci across ocean urban environ help guid ongo effort biotrac environment monitor microbi forens mf
|
D056186;D064307
|
T001;T032;T091;T028
|
36,292,798
|
classif prognosi analysi pancreat cancer base dna methyl profil clinic inform pancreat adenocarcinoma paad poor prognosi high individu variat treatment respons among patient howev standard molecular type method paad prognosi clinic practic analyz dna methyl data cancer genom atlas databas identifi differenti methyl dna gene paad adjac tissu sampl among methyl marker independ affect paad prognosi identifi adjust signific clinic factor base gene two subtyp paad identifi consist cluster fourteen specif methyl gene identifi associ surviv analys transcriptom data identifi differenti express cancer driver gene two paad subtyp degre immun cell infiltr differ signific subtyp specif gene character uniqu methyl pattern subtyp use construct bayesian network base prognost predict model type show good predict valu area curv valu studi provid new insight heterogen pancreat tumor epigenet perspect offer new strategi target person treatment plan evalu precis medicin patient paad
|
D010190;D000230
|
T191
|
36,292,797
|
evalu mean percentag full length smn transcript molecular biomark spinal muscular atrophi elev smn transcript protein level remain princip aim sma therapi still standard molecular biomark assess efficaci current studi test three method smn transcript level measur use real time rt pcr quantit fluoresc rt pcr semiquantit rt pcr gel densitometr assay examin sever potenti mrna base biomark examin sensit reliabl compar obtain valu peripher blood mononuclear cell sma patient sma carrier healthi individu found mean percentag full length fl smn transcript relat total sum fl smn exon delet smn transcript detect semiquantit quantit fluoresc rt pcr differ signific three analyz group relev biomark proven smn target therapeut experi show valu biomark chang signific sma fibroblast cell cultur treatment therapeut antisens oligonucleotid target iss n site intron smn gene obtain result indic conveni use mean percentag fl smn transcript determin semiquantit quantit fluoresc rt pcr putat biomark assess sma therapi efficaci vitro
|
D007963;D009134
|
T047;T025
|
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