PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,293,006 | discoveri novel hiv proteas inhibitor use modern comput techniqu human immunodefici virus type hiv continu global concern new hiv incid emerg multi drug resist untoward side effect current use anti hiv drug urgent need discov effici anti hiv drug modern comput tool play vital role facilit drug discoveri process researc... | D017320;D015497;D019380 | T121;T005 |
36,293,005 | molecular physiolog effect brown agent white adipocyt bone marrow mesenchym stromal cell two differ type adipos depot observ mammal white adipos tissu wat brown adipos tissu bat primari role wat deposit surplus energi form triglycerid along mani metabol hormon activ thermogen tissu bat distinct characterist use energi ... | D052438;D059630 | T025 |
36,293,004 | insight cytochrom p monooxygenas superfamili osmanthus fragran role ofcyp linalool synthesi osmanthus fragran flower long use raw materi food tea beverag perfum industri due attract strong fragranc p superfamili protein report wide particip synthesi plant floral volatil organ compound voc investig potenti function p su... | D055549;D010476;D029592 | T073;T002;T109 |
36,293,003 | experiment studi impact trace amount acetylen methylacetylen synthesi mechan thermal properti polypropylen product polym grade propylen differ process use purifi compound ensur highest qualiti howev impur acetylen methyl acetylen difficult remov impur may present propylen use obtain polypropylen may repercuss process s... | D000114;D011126 | T122;T109 |
36,293,002 | cytoskeleton element contribut prion peptid induc endotheli barrier breakdown blood brain barrier vitro system mechan involv interact prp peptid correspond prion protein amyloidogen region blood brain barrier bbb studi prp treatment previous shown impair bbb function reduc camp level cultur brain endotheli cell increas... | D011328;D020559 | T005;T126;T116 |
36,293,001 | metabol relat gene prognost index predict respons immunotherapi lung adenocarcinoma immunotherapi immun checkpoint inhibitor ici valid strategi treat lung adenocarcinoma luad patient one main challeng ici treatment lack effici biomark predict respons resist metabol reprogram proven remodel tumor microenviron alter resp... | D008175;D000077192 | T191 |
36,293,000 | engin immatur testicular tissu electrospun mat prepubert fertil preserv bioluminesc imag transgen mous model prepubert boy cancer may suffer reduc fertil matur follow gonadotox chemoradiotherapi thus viabl method immatur testicular tissu itt preserv requir cohort studi use poli l lactic acid electrospun scaffold two le... | D059247 | T061 |
36,292,999 | understand bacteriophag tail fiber interact host surfac receptor key blueprint reprogram phage host rang bacteriophag phage natur antibacteri agent rediscov grow threat multi pan drug resist bacteri pathogen global howev estim phage planet find right phage recogn specif bacteri host like look needl trillion haystack ho... | D001435 | T005 |
36,292,998 | protect effect cbd model vitro ischemia may mediat agon trpv channel microglia activ cannabinoid use centuri recreat medic purpos potenti therapeut valu stroke treatment cannabidiol cbd non psychoact compound partial agonist trpv channel efficaci mani neurolog disord investig effect cbd tetrahydrocannabinol thc rat org... | D002185;D018696;D002188;D002186 | T121;T167;T109;T169;T002 |
36,292,997 | ift eclect regul cellular process beyond intraflagellar transport initi discov smallest compon intraflagellar transport ift system ift protein found implic sever unconvent mechan beyond essenti role assembl mainten primari cilium ift consid key player ciliogenesi also vesicular traffick membran receptor signal protein ... | D002352;D002468 | T123;T116;T043 |
36,292,996 | clinic relev circul tumor cell breast cancer epitheli mesenchym characterist singl cell cluster metastat breast cancer mbc typic incur diseas high mortal rate thus earli identif metastat featur diseas recurr precis biomark crucial circul tumor cell ctcs consist heterogen subpopul differ morpholog genet epigenet gene ex... | D009360;D001943 | T191;T025 |
36,292,995 | singl cell analysi better understand mechan involv ms multipl sclerosi chronic inflammatori diseas central nervous system although diseas wide studi mani precis mechan involv still well known numer studi current focus multipl sclerosi highlight involv mani major immun cell subset cd cell cd cell recent b cell howev vis... | D059010;D009103 | T047;T059 |
36,292,994 | iron defici promot lack photosynthet cytochrom c affect bind lumin extrins subunit photosystem ii diatom phaeodactylum tricornutum diatom phaeodactylum tricornutum iron limit promot decreas content photosystem ii determin measur oxygen evolv activ thermoluminesc chlorophyl fluoresc analys protein quantif method thermol... | D017377;D000090463 | T047;T204 |
36,292,993 | pathogenesi port wine stain direct futur therapi port wine stain pwss congenit vascular malform involv skin mucosa date mechan under pathogenesi progress pwss yet clear elucid potenti reason dilat vessel follow somat gnaq rq mutat form enlarg capillari malform like vessel angiopoietin decreas perivascular nerv element ... | D019339 | T019 |
36,292,992 | sexual dimorph gut microbiota chines allig converg wild environ gut microbiota form complex microecosystem vertebr affect various factor key intrins factor sex persist impact format develop gut microbiota studi analyz sexual dimorph gut microbiota particular wild anim use rrna gene sequenc analyz gut microbiota juvenil... | D000489;D000069196 | T014;T007;T001 |
36,292,991 | impact ros depend lipid metabol psoriasi pathophysiolog psoriasi common autoimmun diseas yet pathophysiolog fulli understood believ psoriasi caus increas activ immun cell especi th lymphocyt howev psoriasi immun cell interfer metabol keratinocyt lead increas activ therefor pathophysiolog psoriasi current associ overpro... | D050356;D011565 | T047;T044 |
36,292,990 | character copperzinc superoxid dismutas activ phascolosoma esculenta sipuncula phascolosomatidea protect oxid stress induc cadmium phascolosoma esculenta econom import speci inhabit high tide area intertid zone particular sensit water pollut consid potenti bioindic studi ecotoxicolog p esculenta imper toxic effect cadm... | D002104;D019216 | T131;T196 |
36,292,989 | non genet modifi synapt plastic neurotransmiss central nervous system cns health diseas special edit intend focus influenc non genet factor modifi synapt plastic neurotransmiss health diseas | D009435;D009473 | T042;T043 |
36,292,988 | solid fe resourc separ roll oil sludg co oxid effici recycl valuabl resourc roll oil sludg ros gain new use remain formid challeng studi report recycl solid fe resourc ros catalyt hydrogen techniqu catalyt perform co oxid solid fe resourc calcin air fe h exhibit compar activ prepar calcin ferric nitrat fe c suggest sol... | D012722;D017641 | T197;T069 |
36,292,987 | poison piperidin plant biodivers norditerpenoid alkaloid lead drug discoveri experiment aspect famous exampl simpl eg hemlock conium maculatum l complex eg opium poppi papav somniferum l papaveracea piperidin alkaloid contain plant mani high poison whilst pepper well known gastronom sever substitut piperidin alkaloid t... | D000470;D031841;D004224;D010207 | T123;T121;T109;T131;T002 |
36,292,986 | function zinc sens receptor gpr regul intestin health anim g protein coupl receptor gpr zinc sens receptor znr sens chang extracellular zn mediat zn signal transmiss particip regul numer physiolog activ live organ exampl gpr activ extracellular signal regul kinasemitogen activ protein kinas erkmapk phosphatidylinositol... | D051057;D015032 | T123;T121;T116;T196;T126 |
36,292,985 | phenotyp flexibl egfrviii posit glioblastoma cell line multidirect influenc tgf egf cell egfrviii appear weak oncogen biolog role egfrviii epiderm growth factor receptor variant three remain unclear | D005909;D000076962 | T129;T191;T116;T192 |
36,292,984 | mitochondri dna chang gene respiratori complex iii iv v could relat brain tumour human mitochondri dna chang contribut increas decreas likelihood cancer process complex fulli understood polymorph mutat especi missens type affect mitochondri function particular conserv domain protein concern studi aim identifi possibl r... | D054629;D001932 | T191;T028 |
36,292,983 | genet variant nicotin receptor subunit caus sleep relat hyperkinet epilepsi via increas channel open describ genet molecular level function alter neuron nicotin acetylcholin receptor nachr patient sleep relat hyperkinet epilepsi famili histori epilepsi genet sequenc reveal heterozyg variant cc gt g chrna gene encod sub... | D011978 | T116;T192 |
36,292,982 | present two unrel clinic case republ north ossetia alania previous undescrib variant cola gene describ three affect boy two unrel famili ossetian digor origin republ north ossetia alania admit research centr medic genet unspecifi muscular dystrophi high throughput sequenc perform reveal two novel frameshift variant col... | D009136 | T047 |
36,292,981 | develop sensit screen method simultan determin nine genotox nitrosamin activ pharmaceut ingredi gc ms worldwid crisi nitrosamin contamin medic product began therefor trace level analysi nitrosamin becom emerg topic interest field qualiti control novel gc ms method electron ionize microextract develop valid simultan det... | D009602 | T131;T109 |
36,292,980 | mitophagi relat gene signatur subtyp identif prognosi predict hepatocellular carcinoma global hepatocellular carcinoma hcc sixth common cancer studi correl mitophagi hcc prognosi evalu use data cancer genom atlas tcga clinic transcriptom data hcc patient download tcga dataset mitophagi relat gene mrg dataset obtain mol... | D006528;D008113 | T191 |
36,292,979 | lipas catalyz transesterif model long chain molecul doubl shell cellulos coat oil water emuls particl microbioreactor lipas catalyz transesterif preval industri product effect altern chemic catalysi howev due lipas uniqu structur reaction requir biphas system suffer low reaction effici caus limit interfaci area use emu... | D008049;D002482 | T123;T121;T116;T109;T126;T122 |
36,292,978 | domin prime role waterlog tomato e co multivari analysi frequenc waterlog episod increas due unpredict intens rainfal howev less known waterlog memori interact climat chang event elev co concentr e co studi investig combin effect e co two round waterlog stress growth cultiv tomato solanum lycopersicum wild tomato pimpi... | D018551;D032322 | T168;T002 |
36,292,977 | de novo assembl sarcocarp transcriptom set identifi aamyb regul anthocyanin biosynthesi actinidia arguta var purpurea kiwifruit actinidia arguta var purpurea produc oval shape fruit contain slight green mauv outer exocarp purpl flesh endocarp row tini black seed flesh color fruit result rang anthocyanin compound import... | D029042 | T002 |
36,292,976 | gemcitabin paclitaxel chemotherapi patient advanc urotheli cancer refractori cisplatin base chemotherapi predict role pgk treatment respons cytotox chemotherapi investig altern immun checkpoint inhibitor advanc urotheli cancer auc biolog inform urgent need clinic data patient receiv gemcitabin paclitaxel therapi gp nd ... | D002295;D001688 | T121;T123;T191 |
36,292,975 | subacut pulmonari toxic glutaraldehyd aerosol human vitro airway tissu model glutaraldehyd ga clear center devic radiolog health cdrh food drug administr fda high level disinfect disinfect heat sensit medic equip hospit healthcar facil inhal exposur ga known caus respiratori irrit sensit anim human reproduc known vivo ... | D020397;D004202 | T131;T025;T167 |
36,292,974 | character involv exosom origin chikungunya virus infect epitheli cell transmiss infecti viral element chikungunya virus chikv mosquito born alphavirus affect world popula tion chikungunya diseas adapt viral life cycl host cell environ key step establish infect pathogenesi recent accumul evid advoc princip role extracel... | D002646;D055354;D065632 | T026;T005;T047 |
36,292,973 | effect subthalam stimul electrod implant striatal microenviron parkinson diseas rat model deep brain stimul dbs subthalam nucleus stn consid gold standard treatment pd howev under therapeut mechan need comprehens elucid especi relat glial cell aim understand effect stn microles stn dbs striatal glial cell inflamm extra... | D010300;D046690 | T061;T047 |
36,292,972 | role star scpscpx transport cholesterol lipid cholesterol lipid molecul essenti sever key cellular process includ steroidogenesi traffick distribut cholesterol tight regul various pathway includ vesicular non vesicular mechan one non vesicular mechan bind cholesterol cholesterol transport protein facilit movement chole... | D002352;D002784 | T123;T121;T116;T109 |
36,292,971 | genom wide classif phylogenet analys gdsl type esteraselipas gelp famili flower plant gdsl type esteraselipas gelp enzym key function plant development process anther pollen develop respons biotic abiot stress gene encod gelp belong complex larg gene famili rang ten hundr member per plant speci facilit function transfe... | D004950;D019684 | T126;T116;T002 |
36,292,970 | ex vivo fluoresc confoc microscopi fcm ensur repres tissu prostat cancer biobank feasibl studi biobank prostat carcinoma particular challeng due actual cancer within organ often without clear margin frozen section date way examin biobank materi tumor content use ex vivo fluoresc confoc microscopi fcm analyz biobank sam... | D018070;D011471 | T191;T093 |
36,292,969 | copper amin oxidas cuao mediat polyamin catabol play potenti role sweet cherri prunus avium l fruit develop ripen copper amin oxidas cuao play import role pa catabol plant growth develop abiot stress respons order better understand pa affect cherri fruit four potenti pavcuao gene pavcuao pavcuao dispers two chromosom i... | D000068220;D006631;D017360 | T129;T121;T116;T126;T002 |
36,292,968 | oxid stress amelior novel peptid extract enzymat hydrolys chines pecan cake pecan carya cathayensi import econom crop hydrolyz peptid evidenc reduc effect oxid stress due antioxid capac henc protocol ultrafiltr gel filtrat chromatographi establish obtain bioactiv peptid product c cathayensi pecan cake measur dpphabt ra... | D031325;D001688 | T168;T121;T123;T002 |
36,292,967 | role ion channel mainten sperm motil swim behavior marin teleost ovipar marin fish hyperosmot induct sperm motil seawat sw well establish howev potenti function ion channel mainten post activ spermatozoon swim perform remain larg unknown investig influenc ion channel spermatozoon swim paramet use gilthead seabream spar... | D013081;D021541 | T013;T043 |
36,292,966 | nigella sativa l activ compound thymoquinon clinic manag diabet systemat review despit exist convent hypoglycem drug manag diabet non avail cost low incom countri coupl associ side effect remain major concern consequ explor altern treatment manag diabet continu prioriti nigella sativa l ns famili ranunculacea regard va... | D031881;D003920;D008687 | T121;T047;T002;T109 |
36,292,965 | methylom profil fabri diseas clinic practic proof concept anderson fabri diseas fd x link diseas caus function deficit galactosidas enzym fd diagnosi reli clinic manifest research gla gene mutat howev lack clear genotypephenotyp correl fd diagnosi challeng recent sever studi highlight import investig dna methyl pattern... | D000795 | T047 |
36,292,964 | compar genom phylogenet analysi chloroplast genom three medicin salvia speci bioexplor systemat determin phylogenet relationship develop molecular marker speci discrimin salvia bowleyana splenden officinali sequenc chloroplast genom use illumina hiseq platform chloroplast genom length bowleyana splenden officinali bp b... | D054628;D027544 | T002;T028 |
36,292,963 | tmao upregul member mir cluster impact target associ atherosclerosi atherosclerosi hallmark cardiovascular diseas lifestyl strong impact onset progress nutrient shown regul mir cluster role endotheli function atherosclerosi cholin betain l carnitin found anim food metabol trimethylamin tma gut microbiota tma oxid tmao ... | D002318;D050197;D035683 | T123;T047;T046;T114 |
36,292,962 | sodium algin natur microencapsul materi polymer microparticl multitud materi current avail market use develop microparticl sodium algin becom one studi natur anion polym includ control releas pharmaceut system alongsid polym due low cost low toxic biocompat biodegrad gelatin die form capac presenc ca ion review shown c... | D000464;D011108 | T121;T122;T104;T109 |
36,292,961 | potenti molecular mechan behind ultra high dose rate flash effect flash radiotherapi deliveri dose ultra high dose rate gt gys recent emerg promis tool enhanc therapeut index cancer treatment remark spare normal tissu equival tumor control flash irradi compar convent dose rate irradi flash effect alreadi demonstr sever... | D009369 | T191 |
36,292,960 | upregul mir mir ev renal cell undergo emt urin diabet nephropathi patient diabet nephropathi dn sever kidney relat complic type type diabet frequent caus end stage kidney diseas extracellular vesicl ev present urin main deriv cell nephron thus repres interest tool mirror kidney physiolog state search biomark diseas pro... | D003928;D003924;D000067128;D035683 | T026;T123;T047;T114 |
36,292,959 | mixtur ferul acid p coumar acid suppress colorect cancer lncrna pkm mediat aerob glycolysi polyphenol rich food gain popular due potenti benefici effect prevent treatment cancer foxtail millet one import function food rich varieti biolog activ substanc previous studi show ferul acid fa p coumar acid p ca main anticanc ... | D062085;D015179 | T123;T191;T114 |
36,292,958 | target deubiquitin enzym dub regul mitophagi via direct indirect interact parkin qualiti control mitochondria critic surviv cell defect pathway requir qualiti control lead sever diseas key qualiti control mechan cell mitophagi function remov damag mitochondria condit various stress defect mitophagi lead number diseas i... | D063306;D044767 | T126;T116;T043 |
36,292,957 | effect circumscrib exposur pan aurora kinas inhibitor vx prolifer euploid cell small molecul inhibitor aurora kinas current investig oncolog clinic trial long term effect inhibitor prolifer euploid cell adequ studi examin effect revers pan aurora kinas inhibitor vx p compet human euploid cell circumscrib treatment vx b... | D016159;D009369 | T123;T191;T116 |
36,292,956 | microrna mir diabet retinopathi mir biomark contribut diseas progress diabet retinopathi dr chronic diseas associ diabet mellitus lead caus visual impair among work popul us clinic dr diagnos treat vascular complic advers impact neural retina retin vasculatur degener retin neuron microvasculatur manifest diabet retina ... | D003930;D035683;D003920 | T123;T047;T114 |
36,292,955 | insight superior hydrophob gentamycin term antibiot deliveri bone tissu bone infect serious problem cure system administr antibiot effect due poor bone vascular therefor mani drug deliveri system investig solv problem one potenti solut deliveri antibiot poli l actid co glycolid plga nanoparticl suspend gellan gum injec... | D011100;D053758 | T122;T073;T109 |
36,292,954 | toward real real space refin atom model high qualiti atom model provid structur inform result refin versus diffract data reciproc space refin versus experiment experiment base map real space refin proper real space refin achiev compar map map calcul atom model similar densiti distribut map limit even inhomogen resolut ... | D011487 | T082 |
36,292,953 | evolut gene arrang mitogenom ensifera character complet mitogenom schizodactylus jimo gene arrang relat locat gene anoth evolutionari marker mitogenom provid extens inform evolutionari mechan explor evolut gene arrang mitogenom diversifi ensifera sequenc mitogenom uniqu dune cricket speci found china use phylogenet ana... | D054629;D009987 | T204;T028 |
36,292,952 | wnk osr signal regul angiogenesi mediat metastasi toward develop combinatori anti cancer strategi lysin defici protein kinas wnk critic embryon angiogenesi tumor induc angiogenesi howev downstream effector wnk process remain ambigu studi identifi oxid stress respons b osrb upregul endotheli cell embryon tumor induc ang... | D006528;D008113 | T191 |
36,292,951 | lipid base nanoparticul system ocular deliveri bioactiv anti inflammatori properti complex eye structur physiolog turn ocular drug administr one challeng topic pharmaceut field ocular inflamm one common ophthalm disord topic administr anti inflammatori drug also common use side treatment tissu repair regener difficulti... | D005079;D053758 | T120;T122;T073 |
36,292,950 | sensori neuron specif delet tropomyosin receptor kinas trka mice abolish osteoarthr oa pain via ngftrka intervent peripher sensit tropomyosin receptor kinas trkantrk high affin receptor nerv growth factor ngf potent pain mediat ngftrka signal elev synovi sensori neuron distribut joint caus osteoarthr oa pain investig m... | D020932;D010003 | T123;T047;T116 |
36,292,949 | integr metabolom network pharmacolog deciph latent mechan protopanaxatriol acet acid induc gastric ulcer gastric ulcer gu peptic diseas high morbid mortal rate affect approxim popul throughout world current therapi gu limit high relaps incid side effect therefor novel effect antiulc drug urgent need ginsenosid shown go... | D013276;D036145 | T121;T047;T109 |
36,292,948 | research bioengin novel conotoxin milk venom conus obscurus marin cone snail produc one fastest prey strike anim kingdom inject high efficaci venom often caus prey paralysi death within second snail hundr conotoxin serv sourc discov util novel analges peptid therapeut studi discov isol synthes novel conotoxin deriv mil... | D052078;D020916;D011978 | T123;T116;T192;T131;T204 |
36,292,947 | amyloid lipid metabol basal cholinerg system therapeut alzheim diseas presenc insolubl aggreg amyloid form neurit plaqu nps one main featur defin alzheim diseas studi suggest accumul peptid brain signific contribut extens neuron loss furthermor content distribut cholesterol membran shown import effect product subsequ a... | D016229;D000544 | T047;T116;T048 |
36,292,946 | possibl involv upregul np express mediat activ aryl hydrocarbon receptor mammospher mainten cancer stem cell cscs contribut drug resist recurr metastasi breast cancer recent demonstr overexpress increas mammospher format via activ aryl hydrocarbon receptor ahr studi object identifi mechan under mammospher mainten media... | D018336;D001943 | T191;T116;T192 |
36,292,945 | efdn transgen mice tool evalu ef therapeut target neuropatholog brain age ef initi describ transcript factor key function regul cell quiescenc nevertheless number recent studi establish ef also play relev role cell tissu homeostasi well tissu regener non canon function ef also act cytoplasm abl interact mani homeostat ... | D005911;D000544 | T047;T046;T020;T048 |
36,292,944 | molecular research amyotroph later sclerosi amyotroph later sclerosi al rare progress lethal degen diseas motor neuron treatment current avail | D000690 | T047 |
36,292,943 | sleep modul alcohol toxic drosophila alcohol abus signific public health problem consider research shown alcohol use affect sleep littl known role sleep depriv alcohol toxic investig sleep factor modul alcohol toxic use drosophila melanogast model studi sleep alcohol age follow h sleep depriv use paradigm similar affec... | D029721;D061385 | T123;T121;T116 |
36,292,942 | oxygen glucos depriv promot fibroblast senesc collagen express via il cell senesc one import form injuri induc cardiovascular ischem diseas fibroblast import particip tissu repair ischem injuri main sourc il secret howev role oxygen glucos depriv ogd il promot fibroblast senesc regulatori mechan remain unclear studi se... | D007737;D050503 | T123;T126;T116 |
36,292,941 | transcriptom metabolom analysi pseudomona resist versus suscept arabidopsi access access one plant speci may show signific differ level suscept stress arabidopsi thaliana access col c differ signific resist pathogen pseudomona syringa pv tomato pst help unravel under mechan contribut natur occur varianc resist pst anal... | D017360;D029681 | T116;T002 |
36,292,940 | next step prader willi syndrom research relationship genotyp phenotyp articl review know phenotyp genotyp prader willi syndrom hypothes two possibl path phenotyp genotyp suggest research may strengthen case one hypothes | D011218 | T047 |
36,292,939 | chang farnesen phenol metabol express associ gene develop superfici scald two distinct pear cultivar superfici scald postharvest physiolog disord occur pear cold storag studi superfici scald index farnesen oxid product conjug trienol ctol phenol content express relat gene investig two differ pear cultivar wujiuxiang py... | D031989;D002392 | T168;T121;T002;T109 |
36,292,938 | multi omic reveal mechan partial modul covid dysregul glucocorticoid treatment treatment covid infect improv dramat sinc begin pandem glucocorticoid key tool improv mortal rate uk nation institut health care excel guidanc treatment target requir oxygen supplement howev interact glucocorticoid covid complet understood w... | D005938;D000086382 | T039;T067;T109;T125;T047 |
36,292,937 | insight muscl contract deriv effect small molecular actomyosin modul compound bottom mechanokinet model predict ensembl function actin myosin base paramet valu deriv studi use isol protein general use eg analyz diseas effect model must also abl predict ensembl function actomyosin interact kinet modifi differ normal tes... | D000205;D000199 | T123;T116 |
36,292,936 | import heparan sulfat proteoglycan pancreat islet cell cell islet langerhan pancrea secret insulin respons glucos concentr blood pancreat cell damag diabet develop glucos intoler caus insuffici insulin secret high molecular weight polysaccharid heparin heparan sulfat hs proteoglycan hs degrad enzym heparinas particip p... | D019812;D007515 | T123;T023;T116 |
36,292,935 | discoveri dual senp senp inhibitor sumoyl revers post translat modif ptm involv coval attach small ubiquitin relat modifi sumo protein substrat protein dysregul sumoyl desumoyl result cellular malfunct link various diseas cancer sentrin specif proteas senp identifi matur sumo deconjug sumo substrat protein henc promis ... | D025841;D058207 | T123;T116;T044 |
36,292,934 | explor mysteri tetrahydrobiopterin synthet defect lethal mutant leml birth death silkworm bombyx mori tetrahydrobiopterin bh vital coenzym sever enzym involv divers enzymat reaction anim bh defici lead metabol neurolog disord due dysfunct metabol silkworm natur homozyg mutant leml key enzym sepiapterin reductas bmspr d... | D012831;D010661 | T047;T204 |
36,292,933 | epigenet chang chromatin reorgan brain function lesson fear memori ensembl alzheim diseas healthi brain function mammal requir continu fine tune gene express accumul evid last three decad demonstr epigenet mechan dynam chang chromatin organ critic compon control gene transcript neural cell recent genom wide analys show... | D000544;D019636 | T047;T048 |
36,292,932 | design cyclic peptid base nanospher deliveri sirna recent year cyclic peptid attract much attent due chemic enzymat stabil low toxic easi modif general self assembl nanostructur cyclic peptid tend form nanotub cyclic stack manner hydrogen bond howev studi explor assembl strategi scarc context propos new assembl strateg... | D054118;D043942;D049329 | T073 |
36,292,931 | flavonol quercitrin hinder gsk activ potenti wnt catenin signal pathway wnt catenin signal pathway dictat cell prolifer differenti embryon develop tissu homeostasi deregul associ mani patholog condit includ neurodegen diseas frequent downregul lack effici treatment diseas includ alzheim diseas ad make wnt signal attrac... | D019636;D000544 | T047;T048 |
36,292,930 | melatonin enhanc drought toler rice seedl modul antioxid system osmoregul correspond gene express rice third largest food crop world especi asia product various region affect differ degre drought stress melatonin mt novel growth regul play essenti role enhanc stress resist crop nevertheless under mechan melatonin help ... | D012275;D008550 | T121;T109;T168;T125;T002 |
36,292,929 | physiolog transcriptom analys uncov reason inhibit photosynthesi phosphat defici cucumi melo l phosphat pi defici common phenomenon agricultur product limit plant growth recent work show long term pi defici caus inhibit photosynthesi ineffici electron transport howev under mechan still unknown studi use physiolog histo... | D028463 | T168;T002 |
36,292,928 | ferment angelica tenussima aspergillus oryza improv skin barrier properti moistur anti inflammatori respons angelica tenussima root use tradit medicin asia recent anti melanogen anti photogen effect ferment tenuissima root fat identifi howev inform anti atop dermat action fat limit thus purpos studi determin applic fat... | D014409;D001236 | T129;T004;T116 |
36,292,927 | lc ms base lipidom depict phosphatidylethanolamin biomark tnbc mda mb ntnbc mcf cell breast cancer bc first malign neoplasm women high death rate despit earli diagnos treatment advanc signific differ exist common bc tripl negat breast cancer tnbc tnbc present molecular differ lack express estrogen receptor er progester... | D064726 | T191 |
36,292,926 | microrna milk cell plasma lipid fraction human milk abzym catalyz hydrolysi human milk provid neonat various compon ensur newborn growth includ protect bacteri viral infect neonat biolog function mani breast milk compon differ compar function bodi fluid healthi adult catalyt antibodi abzym hydrolyz peptid protein dnas ... | D017151;D035683 | T123;T116;T114 |
36,292,925 | neutrophil n n subset possibl associ periodont scope review periodont chronic non communic diseas caus dysbiot chang affect subgingiv microbiota periodont neutrophil play central role initi recognit bacteria number increas appear first sign periodont inflamm recent evid led proposit neutrophil also function polar deter... | D009504;D010518 | T047;T025 |
36,292,924 | effect exosom deriv adipos deriv mesenchym stem cell pyroptosi regener injur liver although accumul evid indic exosom posit therapeut effect hepat ischemia reperfus injuri hiri studi focus allevi liver injuri exosom deriv adipos deriv mesenchym stem cell adsc exo base inhibit cell pyroptosi yet report exosom contain di... | D055354;D059630;D035683 | T026;T123;T025;T114 |
36,292,923 | diclofenac sensit signet ring cell gastric carcinoma cell cisplatin activ autophagi inhibit surviv signal pathway gastric cancer one highest incid rate cancer worldwid also contribut increas drug resist among patient clinic practic herein investig role diclofenac dcf sensit cisplatin resist signet ring cell gastric car... | D013274;D018279 | T191 |
36,292,922 | focus pd pd l therapeut target ovarian cancer ovarian cancer consid one aggress deadliest gynecolog malign worldwid unfortun therapeut method consid gold standard moment associ frequent recurr surviv ovarian cancer associ presenc high number intra tumor infiltr lymphocyt til therefor immunomodul consid import role canc... | D060890;D010051 | T129;T191;T116 |
36,292,921 | evolutionari origin metabol reprogram cancer metabol chang facilit tumor growth one hallmark cancer chang specif tumor also take place physiolog growth tissu inde cellular tissu mechan present tumor physiolog counterpart repair tissu lesion wound heal molecular mechan acquir metazoan evolut first elimin infect tissu in... | D009369 | T191 |
36,292,920 | metabolom driven mine metabolit resourc applic prospect improv veget crop veget crop possess promin nutri metabolit pool contribut crop perform field also offer nutrit secur human pursuit identifi quantifi function character cellular metabolom pool biomolecul separ technolog data acquisit platform chemic librari bioinf... | D014675;D054852 | T168;T170 |
36,292,919 | jatrorrhizin improv endotheli function diabet obes suppress endoplasm reticulum stress jatrorrhizin jat one major bioactiv protoberberin alkaloid found rhizoma coptidi hypoglycem hypolipidem potenti studi aim evalu vasoprotect effect jat diabet obes under mechan involv mous aorta carotid arteri human umbil cord vein en... | D004365;D003920 | T123;T047;T121 |
36,292,918 | cdv altern splice form cd promot pancreat cancer progress pancreat cancer one lethal malign tumor howev molecular mechan respons progress littl known studi aim understand regulatori role cdv pancreat cancer kaplan meier analysi perform reveal correl cdcdv express prognosi pancreat cancer patient cdv uaf knock use shrna... | D051057;D010190 | T191;T126;T116 |
36,292,917 | develop two layer hybrid scaffold base oxid polyvinyl alcohol bioactiv chitosan spong tissu engin purpos oxid polyvinyl alcohol oxpva new polym fabric nerv conduit ncs look oxpva devic optim coupl natur sheath may boost bioactiv thus oxpvachitosan spong chs hybrid scaffold investig predict vivo behaviour two layer ncs ... | D048271;D009447 | T121;T191;T109 |
36,292,916 | uncov novel featur pc locus horn develop gene edit holstein cattl rna sequenc analysi poll celtic pc mutat locus genet simpl singl mutat best choic breed poll cattl use gene edit howev mechan pc locus regul horn develop unclear use gene edit somat cell nuclear transfer embryo transfer obtain poll holstein fetal bovin g... | D006733 | T023 |
36,292,915 | intron depend independ pseudouridyl precursor trna contain atyp intron cyanidioschyzon merola eukaryot precursor trnas pre trnas often intron posit anticodon loop howev atyp intron found eukaryot archaea earli diverg red alga cyanidioschyzon merola trna ile uau gene contain three intron code region locat anticodon arm ... | D011560;D000461 | T123;T002;T114 |
36,292,804 | theori design strategi support implement genom nephrolog background genom test increas util clinic tool howev integr nephrolog remain limit purpos studi identifi barrier priorit intervent widespread implement genom nephrolog method qualit semi structur interview conduct australian adult nephrologist determin perspect i... | D009398 | T091 |
36,292,803 | genom wide identif character oat avena sativa l wrki transcript factor famili wrki famili wide involv regul plant growth stress respons one largest gene famili relat plant environment adapt howev systemat studi wrki famili oat avena sativa l conduct date recent publish complet genom sequenc oat enabl systemat analysi a... | D014157;D018554 | T123;T116;T002 |
36,292,802 | advanc novel anim vitamin c biosynthesi pathway role prokaryot base infer understand origin vitamin c vc essenti nutrient requir optim function develop mani organ vc studi mani decad still today character function dynam scientif field main commerci therapeut applic review discuss compar way increas evid altern vc synth... | D004331;D001205 | T121;T127;T204;T109 |
36,292,801 | integr lncrnas protein code gene patholog imag detect metastat melanoma melanoma lethal skin diseas develop mole studi aim integr multimod data predict metastat melanoma high aggress difficult treat propos ensembleskcm method evalu predict perform long noncod rnas lncrnas protein code messeng gene mrnas patholog imag i... | D062085;D008545;D016609 | T123;T191;T114 |
36,292,800 | light chain domain especi c terminus receptor bind domain botulinum neurotoxin bont hotspot amino acid variabl toxin type divers botulinum neurotoxin bont potent toxin world produc dozen strain within sever clostridi speci toxin produc caus botul flaccid paralysi human anim seven establish serolog differ type subtyp bo... | D001905;D001906 | T121;T116;T131;T037;T047 |
36,292,799 | supervis machin learn enabl geospati microbi proven recent increas public avail metagenom dataset geospati metadata made possibl determin locat specif microbi fingerprint around world fingerprint use compar microbi nich environment research well applic within forens scienc public health determin region specif environme... | D056186;D064307 | T001;T032;T091;T028 |
36,292,798 | classif prognosi analysi pancreat cancer base dna methyl profil clinic inform pancreat adenocarcinoma paad poor prognosi high individu variat treatment respons among patient howev standard molecular type method paad prognosi clinic practic analyz dna methyl data cancer genom atlas databas identifi differenti methyl dna... | D010190;D000230 | T191 |
36,292,797 | evalu mean percentag full length smn transcript molecular biomark spinal muscular atrophi elev smn transcript protein level remain princip aim sma therapi still standard molecular biomark assess efficaci current studi test three method smn transcript level measur use real time rt pcr quantit fluoresc rt pcr semiquantit... | D007963;D009134 | T047;T025 |
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