PMID
int64 35.7M
36.4M
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36,292,796
|
allel specif disrupt common stat autosom domin allel suffici restor downstream signal patient deriv cell domin negat mutat stat gene account autosom domin hyper ige syndrom ad hie patient typic present high ige serum level recurr infect soft tissu abnorm current therapi focus allevi symptom hematopoiet stem cell transplant hsct recent propos strategi treat immunolog defect stabil diseas especi case sever lung infect howev potenti sever side effect associ allogen hsct consid patient autolog hsct repres safer altern requir remov domin negat mutat patient cell prior transplant develop allel specif crispr cas nucleas select disrupt five common stat domin negat allel test ex vivo patient deriv hematopoiet cell allel specif disrupt frequenc vari allel depend fashion reach allel harbor vm mutat without detect alter healthi stat allel howev assess gene express profil stat downstream target gene reveal upon activ edit patient cell mono allel stat express function haploinsuffici abl suffici restor stat depend signal edit cell cultur vitro moreov stochast mutagenesi induc repair nucleas induc dna break could contribut domin negat effect summari result advoc precis genom edit strategi rather allel specif gene disrupt correct under mutat ad hie
|
D007073;D007589
|
T129;T047;T116
|
36,292,795
|
select signatur crisprca mediat gene knockout analys reveal zch involv cold adapt chines nativ cattl cold stress import factor affect cattl health product perform reproduct effici understand potenti mechan under genet adapt local environ particular extrem cold environ limit use flk hapflk method found zinc finger ccch type contain zch gene underw posit select menggu fuzhou anxi shigats hump cattl breed distribut cold area china furthermor zch express signific increas bovin fetal fibroblast bff cell c h zch knockout bffs generat use crisprca wild zch delet bffs treat two temperatur divid four group wt wild cultur c ko zch c wtlt wild c h kolt zch c h total differ express gene two fold two fold chang identifi determin transcriptom differ kolt vs ko wtlt vs wt ko vs wt kolt vs wtlt respect loss zch dysregul pathway involv thermogenesi immun zch particip immun relat pathway induc cold stress regul gene involv glucos lipid metabol lipid transport pltp apoa therebi facilit adapt cold stress find provid foundat studi function zch cold stress develop bovin breed strategi combat influenc cold climat
|
D064113;D022722
|
T040
|
36,292,794
|
integr metabolit transcriptom profil mediat gene mine sida cordifolia reveal medicin import gene sida cordifolia medicin shrub convent use indian system medicin howev gene contribut medicin properti minim explor thus limit applic high throughputsequenc liquid chromatographi tandem mass spectrometri lc msms technolog appli unravel medicin import bioactiv compound result transcriptom sequenc generat gb clean data transcript obtain de novoassembl transcript broad classifi class base gene ontolog classif unigen annot use kyoto encyclopedia gene genom kegg databas unigen involv biosynthesi secondari metabolit lc msms analysi three tissu sida cordifolia reveal acacetin procyanidin import metabolit identifi thatcontribut medicin valu sever key enzym witha crucial role phenylpropanoid flavonoid biosynthet pathway identifi especi phenylalanin ammonia lyas might import rate limit enzym real time quantit revers transcript polymeras chain reaction qrt pcr analysi reveal enzym phenylalanin ammonia lyas pal cinnamyl alcohol dehydrogenas cad cinnamoyl coa reductas cf tran cinnam monooxygenas tcm predomin express root compar leaf stem tissu studi provid specul insight screen activ metabolit metabol engin sida cordifolia
|
D044945
|
T121;T109
|
36,292,793
|
interact environment factor glutathion transferas gst gene respect detect blood aluminum concentr jamaican children aluminum al metal toxic high concentr follow natur unnatur exposur dietari intak consid main sourc aluminum exposur children use data typic develop td children age year particip control age sex match case control studi jamaica investig addit interact associ among environment factor children genotyp glutathion transferas gst gene gstt gstm gstp relat detect blood aluminum concentr balc gt gl use multivari logist regress model find interact model reveal odd detect balc signific higher among children ate string bean p wherea lower odd detect balc observ children higher parent educ level p signific interact consumpt saltwat fish gstp relat detect balc use either co domin domin genet model overal interact p model indic consumpt saltwat fish associ higher odd detect balc among children gstp ilev ileil genotyp use either co domin domin model ci p ci p sinc first studi jamaica report find replic popul warrant
|
D000535;D011110
|
T045;T121;T196
|
36,292,792
|
multilocus phylogeographi popul genet analys opsariichthi hainanensi reveal pleistocen isol follow high gene flow around gulf tonkin ichthyofauna continent island character immigr land bridg due fluctuat sea level hainan island adjac southern margin mainland china provid opportun understand origin diversif freshwat fish aim studi evalu level genet variat phylogeograph structur opsariichthi hainanensi hainan island mainland china use mtdna cyt b gene bp loop bp nuclear rag gene bp microsatellit loci mitochondri phylogenet analysi identifi five major lineag accord geograph distribut differ popul suggest two dispers event occur popul changhua river migrat red river lineag b popul south hainan region move northward north hainan region howev popul northwest hainan island dispers popul around gulf tonkin lineag popul northeast hainan island dispers popul mainland china lineag result indic popul hainanensi suffer bottleneck event follow recent popul expans support abc analysi suggest hainanensi popul found most lowland lack suitabl freshwat habitat southern mainland china hainan last interglaci period expans occur last glacial maximum
|
D051456;D003531
|
T045;T013
|
36,292,791
|
genom wide identif potenti mrnas drought respons wheat triticum aestivum l plant cell metabol inevit form import drought respons mechan halt crop product global total harvest area affect dehydr rna seq technolog enabl biologist identifi stress respons gene relat quick time howev one shortcom technolog inconsist data generat compar part world tri generat consensus analyz meta transcriptom data avail public microarray databas geo ncbi way aim set identifi stress gene common identifi differenti express p lt follow downstream analys search term drought wheat result microarray experi geo ncbi databas discard empti dataset contain express data larg scale meta transcriptom analyt one sampl proport test carri bonferroni adjust p lt reveal set drought respons gene global scale annot gene reveal transcript factor activ rna polymeras ii sequenc specif dna bind mechan signific role drought respons wheat similar primari root differenti zone annot control traescsag traescsbg gene found top enrich term p lt q lt result standard drought gene glycosyltransferas arabidopsi thaliana knot like bhlh famili protein probabl helicas magatama sbp famili protein cytochrom c oxidas subunit trihelix famili protein mic domain contain protein erf famili protein hd zip protein erf famili protein import term worldwid prove link stress futur perspect studi could import breed program contribut increas crop yield moreov wheat varieti could identifi drought resistantsensit base natur gene express level
|
D014908;D017360
|
T168;T002
|
36,292,790
|
postop hypocalcemia follow non cardiac surgic procedur children q delet syndrom guidelin manag children q delet syndrom qds highlight risk develop hypocalcemia surgeri recommend monitor calcium periop despit guidanc littl publish postop hypocalcemia qds goal evalu frequenc periop calcium monitor examin often postop hypocalcemia identifi retrospect chart review patient q center repositori inclus criteria diagnosi qds histori non cardiac surgic procedur data collect includ non cardiac surgeri periop calcium lab total patient includ underw cardiac surgeri patient surgeri postop calcium test test show hypocalcemia patient histori hypocalcemia time chart review undergo non cardiac surgeri test postop time howev hypocalcemia similar patient without histori hypocalcemia postop test occur time hypocalcemia studi demonstr postop hypocalcemia children qds follow non cardiac surgeri common affect patient without prior histori hypocalcemia data support establish protocol periop testingmanag hypocalcemia patient qds
|
D006996;D004062
|
T047
|
36,292,789
|
adapt respons transcriptom analysi flax linum usitatissimum l seedl salt stress soil salin constrain agricultur develop arid region flax econom import crop mani countri screen breed salin resist flax cultivar necessari base previous screen flaxse cultivar c salt sensit c salt toler test materi flax seedl stress differ concentr nacl mmoll day use investig effect salt stress growth characterist osmot regul antioxid capac flax seedl reveal adapt respons flax seedl salt stress result show plant height root length flax inhibit c show lower growth c concentr osmot adjust substanc solubl sugar solubl protein prolin higher resist materi c sensit materi c differ concentr salt stress consist c show better rapid scaveng abil reactiv oxygen speci ros maintain higher activ antioxid enzym balanc salt injuri stress inhibit growth salt stress transcriptom analysi flax reveal gene relat defens senesc signific upregul gene relat growth develop process signific downregul salt stress result indic one import adapt toler high salt stress complex physiolog remedi rapid promot transcript regul flax
|
D019597
|
T002
|
36,292,788
|
compar biochem transcriptom analys provid new insight phytoplasma infect respons cucumb flat stem witch broom phytoplasma like symptom cucumb inbr line c observ greenhous yangzhou univers china three consecut plant season symptom result decreas yield better understand caus symptom rrna pcr plant hormon miner element rna seq profil perform use symptomat normal stem sampl result show causal agent classifi candidatus phytoplasma asteri strain plant pathogen prokaryot could cultur vitro measur plant hormon show auxin salicyl acid jasmon acid content signific increas wherea ethylen immedi biosynthet precursor aminocyclopropan carboxyl acid decreas phytoplasma infect stem compar healthi stem furthermor measur miner element composit show magnesium calcium sodium iron zinc concentr signific chang phytoplasma infect cucumb stem compar uninfect stem compar rna seq identifi differenti express gene includ upregul downregul gene analys suggest gene relat phenylpropanoid biosynthesi phenylalanin metabol plant hormon signal transduct contribut phytoplasma infect taken togeth studi present first depth assess diseas symptom biochem content cucumb stem known infect phytoplasma
|
D018553;D045582
|
T168;T007;T002
|
36,292,787
|
identif candid gene twin birth dezhou donkey detect signatur select genom data twin trait donkey import manifest high fecund report avail elucid genet mechan explor genet mechan under twin colt trait dezhou donkey dna femal dezhou donkey birth singl twin colt collect whole genom resequenc f st tajima use detect select sweep singl twin colt fecund dezhou donkey group anoth set femal dezhou donkey singl multipl follicl estrus select compar concentr reproduct hormon includ follicl stimul hormon fsh lutein hormon lh estradiol e progesteron p four candid gene includ eno ptpn sod cd identifi present studi cd gene highest f st valu eno ptpn sod screen two joint analys f st tajima signific differ lh fsh p level two group p gt howev serum e content multi follicl group signific higher singl follicl group p lt identifi candid gene may provid new insight genet mechan donkey prolificaci may use target research high reproduct effici
|
D011374;D018397
|
T123;T121;T109;T015;T125
|
36,292,786
|
mesenchym stem cell base strategi retin diseas retin diseas major caus irrevers vision loss blind despit extens research pathophysiolog etiolog pharmacotherapi effect surgic outcom remain poor base larg numer preclin studi administr mesenchym stem cell mscs therapeut strategi retin diseas hold great promis various approach appli therapi howev hinder retin barrier initi vision stem cell replac strategi fail achiev anticip effect question accumul evid suggest paracrin effect may play domin role msc base treatment msc deriv extracellular vesicl emerg novel compel altern cell free therapi review summar therapeut potenti current strategi fascin class cell retin degener retin dysfunct
|
D045164;D059630;D000067128;D012164
|
T061;T047;T025;T026
|
36,292,785
|
novel de novo nfkbia missens mutat associ ectoderm dysplasia dysgammaglobulinemia inborn error immun iei compris heterogen group genet disord affect immun function report month old malay patient suspect hyper igm syndrom type iei describ howev diagnosi hyper igm syndrom exclud normal function studi mild featur ectoderm dysplasia observ clinic phenotyp inspect
|
D053306;D007153;D004476;D004406
|
T019;T047
|
36,292,784
|
singl nucleotid polymorph translat radic amino acid substitut ligand bind site fasciola hepatica carboxylesteras b fasciola hepatica anthelmint resist may associ catalyt activ xenobiot metabol enzym gene express one enzym identifi carboxylesteras b cestb previous describ induc adult parasit anthelmint treatment exhibit singl nucleotid polymorph posit translat radic amino acid substitut posit glutam acid lysin alphafold model allel sequenc exhibit signific affin pocket rearrang differ ligand dock model result bioinformat analysi confirm radic amino acid substitut locat ligand affin site enzym affect affin serin hydrolas inhibitor prefer ester ligand field genotyp survey parasit sampl obtain two development stage isol differ host speci argentina mexico exhibit allel distribut e allel distribut k well ek heterozyg distribut linkag host speci geograph origin found allel variant
|
D005210;D000871
|
T121;T204
|
36,292,783
|
effect differ rear system lueyang black bone chicken meat qualiti amino acid composit breast muscl transcriptom qualiti poultri product depend genotyp rear system environ aim studi investig effect differ rear system meat qualiti amino acid composit breast muscl transcriptom lueyang black bone chicken lueyang black bone chicken n random divid three group cage flat net free rang group three replic per group chicken per replic week total healthi chicken six male six femal per group collect breast muscl sampl detect meat qualiti paramet amino acid composit fatti acid content furthermor breast muscl six random hen group use rna seq analysi result reveal valu ph shear forc inosin monophosph imp palmit acid linol acid free rang group signific higher cage group p lt fat content free rang group signific lower cage flat net group p lt glutam glu level amino acid crucial umami tast signific higher free rang group cage group p lt meanwhil signific differ free rang flat net group p gt breast muscl transcriptom result show differ express gene deg among three comparison group cage vs free rang flat net vs cage flat net vs free rang respect main relat muscl develop amino acid metabol pathway valid accuraci transcriptom data eight gene gos asn nmrk gadl smtnl slca ampd glul relat fat deposit skelet muscl function flavor format select real time quantit pcr rt qpcr verif conclus result suggest rear system signific influenc meat qualiti gene express lueyang black bone chicken data prove free rang flat net system may provid better flavor consum affect deposit flavor substanc express relat gene find provid valuabl theoret basi rear system select poultri industri
|
D002645;D007291
|
T123;T121;T012;T114
|
36,292,782
|
assess genet divers run homozygos signatur select tropic milk criollo cattl use pedigre genom data object studi evalu genet divers tropic milk criollo cattl tmc breed mexico paramet deriv pedigre genom inform assess pedigre file consist anim seventi nine bovin genotyp medium densiti singl nucleotid polymorph chip consid refer popul pedigre analysi effect popul size probabl gene origin use assess evolut genet divers calcul pedigre inform inbreed coeffici evalu base pedigre fped genom relationship matrix fgrm run homozygos froh differ length class averag inbreed fped fgrm froh respect correl fped froh signific run homozygos gt mb indic fped popul averag equival complet generat five recov recent inbreed paramet probabl gene origin indic exist genet bottleneck loss genet divers histori tmc cattl popul howev pedigre genom inform reveal exist current suffici genet divers design sustain breed program
|
D007178;D023281
|
T040;T091
|
36,292,781
|
systemat analysi immun infiltr predict prognosi clear cell renal cell carcinoma base inflamm signatur clear cell renal cell carcinoma ccrcc frequent kind kidney malign inflamm physiolog respons immun system harm stimuli notabl role inflamm play ccrcc still unknown studi consensus cluster analysi sort ccrcc specimen tcga dataset c c cluster c cluster compris ccrcc specimen high tnm stage tumor grade specimen character activ inflammatori respons immunosuppress microenviron seven gene inflamm relat risk signatur design employ lasso cox regress analys inflamm relat gene ccrcc specimen classifi two group high low risk calcul risk score specimen group high risk show poor prognosi posit correl immun inhibitori factor moreov nomogram creat incorpor inflamm relat risk signatur clinic characterist roc dca curv indic satisfactori effici nomogram predict surviv outcom furthermor identifi potenti therapeut drug molecul cmap analysi find studi may act guid research new prognost biomark therapi
|
D002292;D007680
|
T191
|
36,292,780
|
novel modul promot horizont gene transfer azorhizobium caulinodan or zorhizobium caulinodan or contain kb integr conjug element ice ac conjug transfer symbiosi gene rhizobia mani hypothet redund gene fragment rgfs abund ice ac potenti function horizont gene transfer hgt unknown molecular biolog method employ delet hypothet rgfs expect acquir minim ice ac consid non function rgfs edit region insert gene relat new symbiot function determin signific rgf hgt identifi physiolog function gene design rihfa azc rihfb azcr rihr azc frame delet complement assay reveal rihfa rihfb work unit rihf posit affect hgt frequenc emsa assay lacz base report system show xre famili protein rihr regul rihf promot express integras intc report upregul lysr famili protein ahar sens host flavonoid overal conserv modul contain rihf rihr character elimin size ice ac propos feasibl construct minim ice ac element facilit exchang new genet compon essenti symbiosi metabol function soil bacteria
|
D020599;D049931
|
T007;T002
|
36,292,779
|
ppargca gene respons thrifti metabol relat metabol diseas scope review thrifti genotyp hypothesi thus far describ relationship specif gene popul resili food scarciti circumst link widespread preval genet diseas metabol syndrom adequ map purpos studi discov gene respons thrifti metabol systemat search keyword perform relev titl studi use articl databas publish pubm proquest ebsco januari septemb paper screen elig final evalu determin five studi includ analysi result indic ppargca glyser led high bmi tongan popul unrel onset type diabet mellitus case maori popul signific differ frequenc ppar ct proala gene polymorph observ iranian popul gwas identif addit gene asian european popul produc consist find summari ppargca glyser address gene respons thrifti metabol pacif popul although studi show inconsist result
|
D003924
|
T047
|
36,292,778
|
compar present mous model recapitul featur alport syndrom alport syndrom hereditari kidney diseas caus mutat three gene encod collagen iv cola cola cola sever mous model creat studi diseas variabl phenotyp outcom review date present current mous model exist literatur detail comparison phenotyp featur character model although human primarili glomerulopathi data suggest mous model initi symptom appear tubul interstiti region rather glomerulus addit model sever diseas tubul interstiti region affect genet background conclus phenotyp spectrum model appear affect model genet background posit genet alter within gene type genet alter despit dispar mous model recapitul relat high fidel sever featur human diseas make use studi aim better understand cellular pathomechan find new treatment
|
D009394
|
T047
|
36,292,777
|
banana mawrki mawrki mawrki mawrki gene encod function transcript factor display differenti express respons defens phytohormon wrki transcript factor tfs play key role plant defens respons phytohormon signal pathway howev function tropic fruit crop especi banana remain larg unknown sever wrki gene model plant rice oswrki arabidopsi atwrki atwrki atwrki shown attract tfs engin diseas resist studi isol four banana cdnas mawrki mawrki mawrki mawrki homolog rice arabidopsi wrki gene wrki cdnas isol wild banana musa acuminata ssp malaccensi resist sever diseas crop progenitor banana cultivar deduc amino acid sequenc four mawrki cdnas reveal presenc conserv wrki domain amino acid zinc finger motif n terminus base number wrki repeat structur zinc finger motif mawrki mawrki belong group ii wrki tfs mawrki mawrki member group iii correspond protein locat nuclei onion epiderm cell shown function tfs yeast cell moreov express analys reveal major mawrki gene upregul salicyl acid sa methyl jasmon meja phytohormon although express level relat higher meja treatment fact banana wrki gene upregul sa meja involv system acquir resist sar induc system resist isr respect make interest candid bioengin broad spectrum resist crop
|
D028521;D017360
|
T168;T002
|
36,292,776
|
rna modif relat genet variant genom loci associ bone miner densiti fractur genom wide associ studi gwass identifi loci bone miner densiti bmd function variant loci less known aim studi identifi rna modif relat snps rnam snps bmd gwas loci evalu associ rnam snps quantit heel ultrasound bmd ebmd individu femor neck fn lumbar spine ls bmd individu fractur million individu furthermor perform function enrich qtl mendelian random analys support function identifi rnam snps found rnam snps signific associ bmd includ c g relat snps snps op suscept gene wnt wls sptbn sem fubp lrp jag identifi function enrich snps ebmd gwas dataset detect eqtl signal found near half identifi rnam snps affect gene express associ bmd fractur rnam snps also associ plasma level protein cytokin cytokin receptor interact pik akt signal nf kappa b signal mapk signal pathway moreov plasma level protein ccl cola ctsb efna il insr kdr lifr met plxnb pathway found associ ebmd mendelian random analysi studi identifi function variant potenti causal gene bmd fractur gwas loci suggest rna modif may play import role osteoporosi
|
D015519;D050723
|
T201;T081;T037
|
36,292,775
|
time vari gene express network analysi reveal conserv transit state hematopoiet differenti human mous background analys gene network elucid hematopoiet differenti singl cell gene express data algorithm generat singl static network gene interact chang time biolog meaning examin time vari structur captur dynam even transient state cell cell relationship method transcriptom atlas hematopoiet stem progenitor cell use network analysi pseudo time order monocl loggl use infer time vari network explor chang differenti gene network time rang network analysi tool use examin properti gene infer network result share characterist attribut evolut differenti gene network show u shape network densiti time three branch human mous differenti appear continu process origin stem cell brief transit state mark fewer gene interact stabil progenitor state human mous share hub gene evolutionari network conclus conserv network dynam hematopoiet system mous human reflect share hub gene network topolog chang differenti
|
D053263;D006413
|
T022;T044
|
36,292,774
|
cardiolipin regul mitochondri ultrastructur function mammalian cell cardiolipin cl uniqu tetra acyl diphosphatidylglycerol lipid main local inner mitochondria membran imm mammalian cell play central role regul mitochondri architectur function defici cl biosynthesi remodel perturb mitochondri function ultrastructur clinic experiment studi human patient anim model also provid compel evid abnorm cl content acyl chain composit local level oxid may direct link multipl diseas includ cardiomyopathi neuron dysfunct immun cell defect metabol disord central role cl regul pathogenesi progress diseas attract increas attent recent year review focus advanc understand physiolog role cl biosynthesi remodel human patient mous model provid overview potenti mechan cl regul mitochondri architectur function
|
D002308;D008928
|
T026;T043;T109
|
36,292,773
|
epigenet proteom biomark elev alcohol use predict epigenet age cell type variat better self report excess alcohol consumpt eac general accept effect morbid mortal outcom thought reflect measur epigenet age ea associ self report eac ea consist expect underscor need readili employ non self report tool accur assess monitor contribut eac acceler ea newli develop alcohol consumpt dna methyl indic alcohol score at methyl detectr mdr may help test hypothesi use new indic along carbohydr defici transferrin cdt concurr well past self report eac well establish measur cigarett smoke examin relationship eac acceler ea immun cell count cohort young black american adult found mdr cdt at intercorrel even control gender cotinin effect correl ea self report eac low non signific replic prior research wherea correl non self report indic signific substanti compar non self report indic show at predict four time much varianc ea cdt cell b cell mdr cdt better predict indic acceler ea conclud non self report indic differ predict capac respect key alcohol relat health outcom at may particular use clinician seek understand prevent acceler ea result also underscor likelihood substanti underestim problemat use self report use reduct correl ea varianc cell type
|
D040901;D003367
|
T121;T091;T109
|
36,292,772
|
refer gene select qpcr analysi schima uperba abiot stress quantit real time pcr qpcr indispens techniqu gene express analysi modern molecular biolog select evalu suitabl refer gene prerequisit accur gene express analysi schima superba valuabl tree speci environment adapt high fire resist studi candid refer gene select check stabil gene express differ tissu abiot stress cold stress salt stress drought stress ct genorm normfind bestkeep reffind result indic ap stabli express overal cold stress drought stress eif gene express stabl salt stress treatment ubq express stabl across matur leav shoot stem root contrast ubc gapdh tub least stabli express gene test studi deliv valid refer gene superba differ experiment condit provid import resourc subsequ elucid abiot stress adapt mechan gene biolog import
|
D017343;D018506
|
T045;T028
|
36,292,771
|
novel transcriptom approach investig molecular patholog vitreous retin detach retin detach rd one common sight threaten ocular condit requir emerg intervent posterior vitreous detach pvd occur major age popul wherebi vitreous bodi separ retina well establish pvd common precursor common form rd howev remain unknown individu pvd caus nofew complic physiolog pvd small percentag caus retin tear detach patholog pvd despit year scientif research anatom definit pvd pathogenesi remain controversi recent research identifi novel cell popul laminocyt present signific higher number patholog pvd compar physiolog pvd review summaris seven distinct clinic sub group retin break focus role laminocyt secondari pvd transcriptom profil uniqu cell provision whole transcriptom analysi use bulk rna seq show mark differenti express gene compar physiolog pvd pvd associ rd limit bulk rna seq consid potenti address use spatial transcriptom discuss understand pathogenesi pvd relat retin tear provid baselin develop novel therapeut target prophylact treatment
|
D012163;D012167;D020255
|
T047
|
36,292,770
|
flashforward look solut fruit veget product one import challeng face current futur generat climat chang continu popul growth advers affect food secur address food system need complet transform produc non optim space limit area reduc negat environment impact fruit veget essenti human health high valu ad crop grown greenhous open field environ review potenti practic reduc impact climat variat ecosystem damag fruit veget crop yield well highlight current bottleneck indoor outdoor agrosystem obtain sustain high tech greenhous increas import biotechnolog mean becom instrument design crop tomorrow discuss key trait need studi improv agrosystem sustain fruit yield
|
D014675;D005638
|
T168;T002
|
36,292,769
|
host genet risk factor associ covid suscept sever vietnames sinc emerg rapid transmiss sar cov numer scientif report search associ host genet variant covid data most acquir europ current work explor link host gene sar cov entri immun system relat covid sensitivitysever abo blood type covid whole exom data covid patient control vietnam blood type found protect factor weaken worst outcom infect individu sar cov suscept rs tc genotyp allel c rs allel ifnar increas risk infect rs ct genotyp allel slca reduc virus sensit covid progress frequenc rs tg genotyp rs tc genotyp adam signific higher moder group severefat group variant rs aa genotyp tmprss signific associ asymptomaticmild symptom addit rs ct genotyp allel tyk rs ag genotyp dpp associ severefat outcom studi differ popul give better insight pathogenesi ethnic depend thus deciph genet factor contribut mechan predispos peopl vulner covid
|
D000086382
|
T047;T067
|
36,292,768
|
express sweet potato myb transcript factor ibmyb confer salt drought toler arabidopsi sweet potato ipomoea batata l lam one crucial food crop wide cultiv worldwid plant myb transcript factor play crucial role plant growth defens regul stress resist howev regulatori mechan myb salt drought respons remain poor studi sweet potato screen transcriptom databas differenti express gene sweet potato varieti jingshu mutant js high anthocyanin increas toler salt drought stress identifi rr myb gene ibmyb express induc peg nacl abscis acid aba methyl jasmon acid meja salicyl acid sa h particl mediat transient transform onion epiderm cell show ibmyb local nucleus transactiv activ assay yeast cell reveal ibmyb transactiv activ activ domain locat carboxyl c termin region furthermor express ibmyb confer enhanc toler salt drought stress transgen arabidopsi content endogen aba ja prolin transgen line higher control activ superoxid dismutas sod signific increas salt drought stress condit contrast accumul malondialdehyd mda h lower moreov gene encod enzym involv aba biosynthet pathway ja biosynthesi signal pathway reactiv oxygen speci ros scaveng system signific regul transgen arabidopsi salt drought stress altogeth result suggest ibmyb may candid gene improv abiot stress toler
|
D017360;D027723
|
T168;T002
|
36,292,767
|
elev etv express glioma promot aggress vitro phenotyp associ shorter patient surviv background gbm astrocyt may adopt fetal astrocyt transcriptom signatur involv brain develop migrat program facilit diffus tumor infiltr previous data show et variant etv high express human gbm fetal astrocyt compar normal matur astrocyt hypothes etv play role gbm tumor progress method express etv first examin two american three chines tissu microarray correl etv stain intens patient surviv calcul follow valid use public databas tcga rembrandt effect etv knockdown glioma cell prolifer edu viabil annexinv label clonogen growth coloni format migrationinvas transwel assay gbm cell test rna sequenc western blot perform elucid under molecular mechan result etv high express gbm associ unfavor prognosi etv silenc glioma cell led increas apoptosi decreas prolifer clonogen migrat invas rna seq base gene express pathway analys reveal etv knockdown u cell led upregul gene involv extracellular matrix organ nf b signal tnf mediat signal downregul gene regul cell motil cell prolifer pik akt signal ras pathway downregul pik akt ras mapk pathway valid immunoblot conclus find suggest etv high express gbm high express correl poor surviv etv silenc decreas aggress vitro phenotyp probabl via pik akt ras mapk pathway studi encourag investig etv potenti therapeut target gbm
|
D005909;D001932;D005910
|
T191
|
36,292,766
|
complet mitochondri genom phylogenet posit two longicorn beetl anoplophora glabripenni demonax pseudonotabili coleoptera cerambycida anoplophora glabripenni motschulski demonax pseudonotabili gressitt rondon two common found longicorn beetl china howev lack suffici molecular data hinder understand evolut phylogenet relationship speci cerambycida studi sequenc assembl complet mitochondri genom two speci use next generat sequenc method mitogenom glabripenni pseudonotabili bp bp length respect mitochondri gene content gene order glabripenni pseudonotabili high conserv sequenc longicorn beetl calcul nonsynonym ka synonym ks substitut rate pcgs indic exist purifi select two longicorn beetl phylogenet analysi conduct use protein code gene sequenc avail mitogenom cerambycida two speci sequenc studi respect group relat subfamili monophyli cerambycina dorcasomina lamiina necydalina well support wherea lepturina prionina spondylidina recov paraphylet
|
D054629;D001517
|
T204;T028
|
36,292,765
|
hereditari metabol bone diseas review pathogenesi diagnosi manag hereditari metabol bone diseas character genet abnorm skelet homeostasi encompass one divers group among rare diseas review examin select hereditari metabol bone diseas recogn genet variat gene repres three group includ scleros bone disord disord defect bone miner disord bone matrix cartilag format also review pathophysiolog manifest treatment diseas advanc molecular genet basic scienc led accur genet diagnosi novel effect therapeut strategi diseas diseas genet basi pathophysiolog remain unclear research therefor crucial innov way overcom diagnost challeng develop effect treatment option orphan diseas
|
D001851
|
T047
|
36,292,764
|
transcriptom wide character pirna development process european honey bee larval gut pirna play pivot role maintain genom stabil regul gene express modul develop immun howev pirna associ studi honey bee regulatori role pirna develop bee gut larg unknown differenti express pattern pirna development process european honey bee api mellifera larval gut analyz follow investig regulatori network potenti function differenti express pirna depirna regul gut develop total pirna identifi larval gut mellifera among pirna share group group day old group larval gut one respect uniqu first base pirna group cytosin c bias addit regul regul pirna identifi vs comparison group target gene involv go term pathway two regul five regul pirna detect vs comparison group target gene engag function term pathway pir ame pir ame vs comparison group well pir ame pir ame vs comparison group found link highest number target analysi indic target depirna two comparison group putat regul seven develop associ signal pathway seven immun associ pathway three energi metabol pathway moreov express trend five random select depirna verifi base stem loop rt pcr rt qpcr result suggest overal alter pirna larval development process demonstr depirna potenti modul develop immun energi metabol associ pathway regul express correspond gene via target bind affect develop mellifera larval gut data offer novel insight develop bee larval gut lay basi clarifi under mechan
|
D059467;D006722
|
T081;T168;T086
|
36,292,763
|
character comparison two new mitogenom crocodil newt tylototriton caudata salamandrida phylogenet implic mitochondri genom mitogenom valuabl resourc molecular evolutionari studi phylogeni popul genet complet mitogenom two crocodil newt tylototriton broadoridgus tylototriton gaowangjienensi sequenc assembl annot first time use next generat sequenc complet mitogenom broadoridgus gaowangjienensi bp bp length compos protein code gene pcgs rrna gene trna gene control region two mitogenom high content posit skew negat gc skew pattern ratio non synonym synonym substitut show relat atp gene evolv fastest coi evolv slowest among pcgs phylogenet tree bi ml analys result ident topolog tylototriton split two group correspond two subgenera broadoridgus gaowangjienensi sequenc belong subgenus yaotriton two speci share tentat sister group relationship two mitogenom report studi provid valuabl data futur molecular evolutionari studi genus tylotoriton salamand
|
D054629;D000489
|
T014;T028
|
36,292,762
|
wild vicia speci possess drought toler system faba bean improv faba bean vicia faba l drought sensit crop drastic affect drought stress compromis growth yield howev wild relat faba bean consid reservoir potenti genet resourc toler abiot stress studi conduct character wild relat faba bean identif specif toler system requir improv drought stress studi focus physiolog biochem anatom respons wild vicia speci drought stress condit experi carri various level drought stress impos differ field capac fc includ fc ie well water condit fc moder stress fc sever stress compar plant grown control environ drought stress signific reduc studi physiolog attribut includ solubl sugar protein content chlorophyl moder fc sever drought stress fc respect howev prolin content increas peroxidas activ superoxid dismutas activ moder sever stress respect studi anatom attribut also affect drought stress treatment includ diamet stem xylem vessel leaf lower epiderm thick leaf phloem width moder sever stress respect wild vicia spp show better toler water deficit condit compar cultiv vicia l observ potenti divers drought toler wild vicia spp may assist improv faba bean may also help understand mechan adapt drought prone environ
|
D031307
|
T002
|
36,292,761
|
compar analysi molecular rflp snp marker assess understand genet divers various chicken breed monitor genet divers small popul import respect conserv rare valuabl chicken breed well discoveri innov germplasm research applic restrict fragment length polymorph rflps molecular marker underli multilocus dna fingerprint mldf histor employ purpos past two decad irrevers shift toward high throughput singl nucleotid polymorph snps studi conduct compar analysi archiv mldf result new data whole genom snp genotyp snpg among diverg select breed repres larg sampl world gene pool result obtain data fit general concept phylogenet distribut studi breed compar rflp snp marker rflps found use marker retrospect assess chang genet architectur variabl under phenotyp variat chicken popul especi sampl previous generat use mldf unavail snpg result facilit research necessari assess possibl extrapol previous mldf result studi long term dynam genet divers various small chicken germplasm popul time general whole genom character popul breed multipl snp loci form basi develop implement genom select aim effect use genet potenti domest gene pool poultri industri
|
D020641;D002645
|
T012;T086
|
36,292,760
|
confound factor impact microrna express human saliva methodolog biolog consider grow interest saliva microrna mirna non invas biomark human diseas approach requir understand differ experiment design affect mirna express variat technic methodolog coupl inter individu variabl may reduc studi reproduc generaliz anoth barrier face salivari mirna biomark research lack recogn control mirna one largest studi human salivari mirna date healthi individu util saliva sampl quantifi variabl mirna express result align select bowti vs bowti saliva collect method expector vs swab rna stabil presenc vs absenc individu biolog factor sex age bodi mass index exercis calor intak differenti express analys reveal absenc rna stabil introduc greatest variabl follow differ method collect align biolog factor general affect smaller number mirna also report coeffici variat mirna consist present saliva highlight sever salivari mirna serv refer gene thus result analysi use research optim paramet salivari mirna measur exclud mirna confound numer biolog factor identifi appropri mirna control
|
D012463;D035683
|
T123;T114;T031
|
36,292,759
|
differ mechan caus hypomethyl h kcnqot imprint differenti methyl region two case silver russel syndrom spectrum silver russel syndrom imprint disord characteris pre post natal growth retard sever heterogen molecular defect affect differ human genom loci major case molecular defect loss methyl lom higf differenti methyl region dmr also known ic telomer domain p imprint gene cluster caus alter express growth control gene igf h rare lom also affect kcnqot dmr also known ic centromer domain result srs phenotyp unknown mechan studi report two case srs featur lom either ic ic one case rare complex epimut secondari de novo mosaic cis matern duplic involv entir telomer p domain part centromer domain lack cdknc second case neither p copi number variant matern effect subcort matern complex scmc variant found associ epimut suggest aros primari event find add complex molecular genet srs indic lom p dmrs may result differ molecular mechan
|
D056730
|
T047
|
36,292,758
|
vdr polymorph variant relat improv crp diseas activ patient axial spondyloarthr undergo anti tnf treatment vitamin defici relat suscept progress various autoimmun diseas aim studi assess potenti relat singl nucleotid polymorph snps vitamin receptor code gene vdr rs bsm rs fok rs taq rs apa diseas activ patient axial spondyloarthr axspa undergo anti tnf therapi vdr rs ct genotyp statist common among femal patient p improv crp equal higher month anti tnf therapi observ rs allel p month crp improv equal higher relat presenc rs aa genotyp p rs cc homozygot p baselin basdai valu lower individu rs tt genotyp p rs c allel p month treatment lower basdai valu observ ac heterozygot p ac genotyp frequent detect patient remiss basdai p achiev basdai improv equal higher p conclus vdr snps found relat crp basdai valu differ time point anti tnf therapi
|
D018167;D000089183
|
T047;T116;T192
|
36,292,757
|
episom transposas util maintain transgen express nonvir vector effici deliveri stabl transgen express critic applic gene therapi care select engin viral vector allow remark clinic success still bear signific safeti risk thus nonvir vector sound altern avoid genotox advers immunolog reaction nonvir vector system extens studi refin last decad emerg knowledg epigenet regul replic spatial chromatin organis well new technolog crisprca employ enhanc perform differ nonvir vector system thus nonvir vector focus hold promis perspect futur applic gene therapi review address three promin nonvir vector system sleep beauti transposas smar base episom viral plasmid replicon base ebv vector exemplarili review differ util modif new concept pursu overcom limit regard stabl transgen express mitot stabil new insight nuclear localis nonvir vector molecul potenti consequ thereof highlight final discuss remain limit provid outlook possibl futur develop nonvir vector technolog
|
D019895;D044127
|
T045;T126;T116
|
36,292,756
|
express variat epa associ oxygen metabol sheep endotheli pas domain protein gene epa member hif gene famili gene encod transcript factor subunit involv induct oxygen regul gene sever studi demonstr mutat epa could affect oxygen sens polycythemia hemoglobin level howev whether epa mutat affect sheep oxygen metabol still unknown therefor explor relationship variat epa oxygen metabol sheep studi variat ovin epa exon investig tibetan sheep hu sheep polymeras chain reaction singl strand conform polymorph pcr sscp analysi addit studi effect variat blood gas tibetan sheep hu sheep final mrna express epa six tissu hu sheep tibetan sheep live differ altitud analyz real time quantit pcr rt qpcr four allel b c detect distribut high differ tibetan sheep hu sheep tibetan sheep b domin allel c allel rare wherea four allel common hu sheep six singl nucleotid polymorph snps identifi four allel one non synonym pfl studi blood gas level tibetan sheep hu sheep one variant region found associ elev p suggest variat epa associ oxygen metabol sheep rt qpcr result show epa express six tissu hu sheep tibetan sheep differ altitud addit express epa four tissu heart liver spleen longissimus dorsi muscl hu sheep lower tibetan sheep three differ altitud express epa posit correl altitud result indic variat express epa close relat oxygen metabol
|
D000531;D006454
|
T081;T123;T116
|
36,292,755
|
genet factor airway epithelium associ patholog asthma asthma chronic diseas airway character inflamm tighten muscl thicken airway wall lead symptom short breath chest tight cough patient increas risk asthma children asthmat parent support exist genet factor involv pathogenesi diseas genom wide associ studi discov sever singl nucleotid polymorph associ asthma polymorph occur within sever gene contribut differ asthma phenotyp affect diseas sever clinic respons differ therapi complex etiolog asthma also result interact environment genet factor environment exposur shown increas preval asthma individu genet suscept review summar current known genet asthma relat risk respons common treatment gene environment interact
|
D055106;D001249
|
T063;T047
|
36,292,754
|
molecular epidemiolog amerindian brazilian amazon reveal new genet variant dna repair gene nativ american popul brazilian amazon low genet divers differ genet profil compar peopl contin despit studi conduct group descript genet data various current exist intern databas character genom profil popul impact studi popul genet also help advanc diagnost therapeut respons studi lead optim clinic applic genet variat dna repair gene associ modul suscept various patholog well prognosi therapi first studi investig dna repair gene amerindian brazilian amazon region investig import dna repair gene exom nativ american compar result found continent popul whose data avail genom aggreg databas result show variant alreadi describ literatur differenti distribut amerindian popul relat continent popul signific clinic relev addit new variant describ suggest uniqu popul studi reinforc understand amazonian nativ american popul present uniqu genet profil find may collabor creation public polici optim qualiti life group well brazilian popul present high degre interethn mix amerindian group
|
D007199;D011788
|
T078;T098
|
36,292,753
|
emerg role microrna autophagi mechan pancreat cancer progress futur therapeut approach pancreat cancer constitut fourth frequent caus death due malign us despit new therapeut modal manag pancreat ductal adenocarcinoma pdac consid difficult task clinician due fact usual diagnos alreadi advanc stage relat resist current chemotherapeut agent molecular background analysi pancreat malign tumor includ various epigenet genet alter open new horizon develop novel diagnost therapeut strategi interplay mirna autophagi pathway pancreat carcinogenesi spotlight current research strong evid mirna take part carcinogenesi either tumor inhibitor combat oncogen express promot oncomir act oncogen interf various cell function prolifer program cell death metabol signal pathway deregul express level various mirna close associ tumor growth progress dissemin well low sensit chemotherapeut agent similar autophagi despit constitut pivot homeostat mechan cell surviv binari role pdac either inhibitor promot carcinogenesi emerg role mirna autophagi get great deal attent open new opportun develop novel therapeut strategi manag aggress chemoresist malign review shed light interplay mirna autophagi mechan pancreat cancer develop progress
|
D035683;D010190;D021441;D000970
|
T121;T123;T109;T191;T114
|
36,292,752
|
genet polymorph associ prothrombin time activ partial thromboplastin time chines healthi popul background purpos studi evalu effect gene polymorph prothrombin time pt activ partial thromboplastin time aptt healthi chines popul method total healthi volunt seri novel oral anticoagul noac bioequival trial china includ coagul test pt aptt perform central lab peke univers first hospit whole exom sequenc wes genom wide associ analysi perform result correl analysi pt snps gene reach genom wide signific threshold p lt zinc finger protein znf rs p signific relat pt actinin alpha actn found interact candid gene signific associ previous report candid gene aurora kinas b aurkb complement c c clock circadian regul clock histon deacetylas hdac detect dataset p lt piggybac transpos element deriv pgbd rs p bromodomain adjac zinc finger domain baza rs p protogenin prtg rs p signific correl aptt p lt herit valu pt aptt respect conclus pt aptt healthi popul affect genet polymorph znf actn variant could novel genet marker pt prtg polymorph might associ aptt level find could attribut ethnic differ need investig
|
D000185;D055106
|
T063;T123;T116
|
36,292,751
|
obes adipos tissu dysfunct pediatr adult obes grow health problem affect children adult increas preval childhood obes associ comorbid cardiovascular diseas type diabet metabol syndrom due chronic low grade inflamm present earli stage diseas pediatr patient suffer obes role epigenet gut microbiom intrauterin environ emerg causat factor interest pediatr obes strong associ low birth weight acceler weight gain oftentim occur individu post natal period lead increas risk adipos metabol diseas pathophysiolog obes complex involv biolog physiolog factor compound societ factor famili communiti cellular level adipocyt contain within adipos tissu becom dysregul contribut develop comorbid similar present adult obes review provid overview current understand adipos tissu immun inflammatori metabol adapt adipos tissu obes earli cellular chang well role immun cell inflamm progress diseas pivot pediatr clinic trial adult studi mous model emphas understand initi molecular cellular chang occur obes facilit new improv treatment aim earli intervent subsequ prevent adulthood comorbid
|
D003924;D063766;D010372
|
T033;T047;T091
|
36,292,750
|
tremend reorgan journey chromatin structur gamet embryo chromatin structur within nucleus import gene express regul correct development program recent rapid develop low input chromatin conform captur technolog made possibl studi chromatin structur gamet zygot earli embryo varieti speci includ fli vertebr mammal distinct chromatin structur within male femal gamet follow fertil male femal gamet fertil egg undergo drastic epigenet reprogram multi level includ chromatin structur convert termin differenti gamet state totipot state give rise individu howev extent chromatin structur reorgan evolutionarili conserv under mechan tremend reorgan earli embryo remain elus review latest find chromatin structur reorgan embryogenesi discuss converg diverg reprogram pattern key molecular mechan chromatin structur reorgan gamet embryo differ speci find shed light chromatin structur reorgan contribut embryo develop differ speci find also indic role chromatin structur acquisit totipot development potenti
|
D005854;D002843
|
T116;T025
|
36,292,749
|
clone toll like receptor gene schizothorax prenanti sptlr express seven sptlrs spmyd lipopolysaccharid induct toll like receptor sptlr schizothorax prenanti prenanti clone identifi tissu distribut sptlr gene examin studi moreov relat mrna express level myeloid differenti factor gene spmyd seven tlr gene sptlr sptlr sptlr sptlr sptlr sptlr sptlr prenanti lipopolysaccharid lps challeng analyz quantit real time polymeras chain reaction qrt pcr full length sptlr gene bp complet code sequenc cds bp encod amino acid sp tlr amino acid sequenc share ident tlr sequenc vertebr sptlr express eight tissu examin highest level appear liver signific higher tissu p lt follow level heart muscl lps signific regul eight gene prenanti tissu h p lt compar pbs control group signific transcript chang found sptlr sptlr h lps induct signific regul h p lt abund transcript found head kidney sptlr gene h lps induct high low level sptlr fold sptlr fold sptlr fold among eight gene express level sptlr least regul overal sptlr head kidney involv antibacteri immun respons earlier level increas h extrem signific lps stimul p lt seven gene signific regul h post inject taken togeth result suggest spmyd sptlr sptlr sptlr sptlr sptlr sptlr sptlr particip innat immun respons stimul lps respons intens gene organ specif differ kinet find contribut complet understand role tlr gene antibacteri immun
|
D008070;D003530
|
T013;T109
|
36,292,748
|
influenc chines herbal formula bone characterist cobb broiler chicken evalu prevent treatment effect chines herbal formula chf bone diseas cobb broiler chicken compar efficaci bisphosphon bps provid theoret basi studi nutrit regul technolog chf improv bone characterist broiler chicken studi one day old cobb broiler chicken examin influenc chines herbal formula chf bisphosphon bps differ dose chf bps ad diet day old live weight tibial bone strength microstructur distal femur cancel bone blood biochem index relat bone metabol gene relat bone metabol determin analyz result show live weight cobb broiler fed chf bps diet follow live weight chf group higher normal control nc group live weight bps group lower nc group chf bps improv bone strength cobb broiler increas elast modulus yield strength maximum stress tibia chf bps increas cancel bone miner densiti bmd bone tissu ratio bvtv bone surfac area tissu volum ratio bstv bone trabecular thick tbth bone trabecular number tbn distal femur decreas bone surfac area bone volum ratio bsbv bone trabecular separ tbsp thus microstructur bone tissu distal femur improv certain extent chf bps also increas serum level vitamin receptor vdr osteoprotegerin opg alkalin phosphatas alp decreas content osteocalcin ot meanwhil chf bps upregul express osteogen gene bmp opg runx promot bone format downregul express osteoclast gene rank rankl tnf inhibit bone resorpt thus affect bone metabol conclus chf could improv skelet characterist cobb broiler upregul express bone form relat gene downregul express bone break relat gene thus prevent control skelet diseas cobb broiler effect compar bps meanwhil chf h group achiev best result promot growth improv skelet characterist cobb broiler base live weight skelet characterist relat index
|
D053244;D002645
|
T116;T012;T192
|
36,292,747
|
chang observ potenti key candid gene peripher immun induc tai chi among patient parkinson diseas parkinson diseas pd common progress neurodegen diseas character motor dysfunct although inhibit inflamm tai chi demonstr involv peripher cytokin respons may play import role improv motor function pd patient relat specif molecular mechan peripher immun respons tai chi fulli understood microarray dataset gse peripher immun respons tai chi pd patient download gene express omnibus databas differenti express gene deg screen analyz use weight gene co express network analysi wgcna total deg found pd patient tai chi suggest effect tai chi peripher immun pd patient deg main involv neutrophil activ cell activ nod like receptor il signal pathway furthermor six key candid gene fos fosb junb zfp camp lcn involv peripher inflamm inhibit inflamm induc tai chi observ result present studi could conduc comprehens understand molecular mechan involv effect tai chi peripher inflamm pd patient provid novel target futur advanc research
|
D026302;D010300;D019636
|
T056;T047
|
36,292,746
|
mir p mir b p regul spermatogenesi bactrocera dorsali target orb gene bactrocera dorsali consid major threat horticultur crop evolv resist insecticid believ develop new method high desir control destruct agricultur pest steril insect techniqu emerg potenti tool control insect pest reduc reproduct abil report orb high express testi b dorsali target mir p mir b p play critic role spermatogenesi dual luciferas report assay use hekt cell demonstr orb gene downregul mir p mir b p common target mirna dietari treatment adult male fli separ combin agomir p ago p agomir b p ago b p signific downregul mrna orb combin treatment agomir suppress level mrna orb signific singl treatment alter express mir p mir b p signific decreas total live spermatozoa testi ultim caus reduct male fertil furthermor demonstr mir p mir b p orb dsrna novel agent could use genet base steril insect techniqu sit control b dorsali
|
D007306;D033621;D035683
|
T131;T123;T204;T114
|
36,292,745
|
microbiom influenc pathogenesi alopecia areata alopecia areata multifactori autoimmun base diseas complex pathogenesi autoimmun diseas genet predisposit key collaps immun privileg hair follicl lead scalp loss major pathogen event alopecia areata microbiota consid bacteri ecosystem locat specif area human bodi could somehow influenc pathogenesi alopecia areata occur autoimmun diseas moreov next generat sequenc rrna bacteri gene metagenom methodolog provid excel character microbiota aim narrat review examin publish literatur cutan intestin microbiota alopecia areata abl establish pathogen link review summar influenc microbiota develop alopecia areata first introduc general pathogen mechan caus alopecia areata understand influenc microbiota may exert summar studi carri type gut skin microbiota found patient diseas
|
D000506;D001327;D064307
|
T001;T047;T032;T028
|
36,292,744
|
express analysi role sec gene regul composit mous gut microbiota sec gene encod galactos l fucosyltransferas wherea express develop sec gene mous effect composit gut microbiota rare report studi examin sec gene express mous develop construct sec knockout mice sequenc gut microbi composit found sec express differ stage mous develop sec knockout mice signific higher intraperiton fat accumul bodi weight wild type mice analysi gut microbi composit sec knockout mice reveal phylum level bacteroidet account gut microbi composit sec sec group respect firmicut account respect firmicut bacteroidet signific higher sec mice sec mice vs verucomicrobia signific higher sec mice sec group mice famili level domin bacteria prevotellacea akkermansiacea bacteroidacea lacilltobacacea found signific reduc gut sec mice among sec gut microb lachnospiracea ruminococcacea rikenellacea helicobacteracea tannerellacea signific increas indic predict also reveal domin bacteria akkermansiacea lactobacillacea sec gut microorgan domin bacteria rikenellacea marinifilacea clostridialesvadinbbacea erysipelotrichacea saccharimonadacea clostridiacea christensenellacea sec group studi reveal sec gene express differ tissu differ time period mice sec knockout mice signific weight gain signific abdomin fat accumul signific chang gut microbi flora abund metabol function provid theoret basi data support studi sec gene function effect gut microbiota relat diseas
|
D000069196
|
T007;T001
|
36,292,743
|
genom signatur freshwat adapt pacif herring clupea pallasii pacif herring clupea pallasii essenti target commerci fish north pacif ocean previous studi suggest exist marin lake ecolog form speci within rang lake ecolog form herring shorten life cycl spend winter spawn brackish water near shorelin without long migrat feed also relat smaller bodi size marin form genet base studi shown brackish water pacif herring distinguish separ lake ecolog form possibl genet legaci part ongo studi use ddrad sequenc data marin lake ecolog form total individu method compar bioinformat describ genom signatur freshwat adapt pacif herring total gene contain discrimin snps found part gene organ genom cluster also known genom island diverg moreov tajima test show loci direct select lake popul pacif herring yet discrimin loci lake marin ecolog form pacif herring intersect gene name known marin fish speci known freshwaterbrackish popul howev associ physiolog trait osmoregul
|
D000222;D060106
|
T083;T040;T070
|
36,292,742
|
popul genet california gray fox clarifi origin island fox use mitochondri sequenc nuclear microsatellit investig popul structur gray fox urocyon cinereoargenteus evolutionari origin endem island fox urocyon littorali first appear northern channel island lt year ago southern channel island lt year ago unclear whether island fox evolv direct mainland gray fox transport island one time extinct mainland popul alreadi diverg gray fox mitochondri sequenc combin previous data confirm island fox monophylet trace recent common ancestor approxim year ago root nuclear dna tree addit indic genom wide monophyli island fox relat western gray fox although detect admixtur northern island fox adjac mainland gray fox consist histor gene flow southern california gray fox also bore genet signatur admixtur connect desert popul consist partial replac late holocen rang expans use outgroup analysi root previous nuclear sequenc base tree indic reciproc monophyli northern versus southern island fox result consist island fox origin multipl introduct extirp mainland popul
|
D005589;D005828
|
T090;T015
|
36,292,741
|
transcriptom respons differenti muscl satellit cell thermal challeng commerci turkey earli muscl develop involv prolifer differenti stem cell satellit cell scs mesoderm form multinucl myotub matur muscl fiber fiber bundl prolifer scs increas number cell avail muscl format simultan maintain popul cell futur respons differenti dramat chang properti scs environment stressor long last effect muscl growth physiolog studi design character transcript chang induc turkey scs undergo differenti thermal challeng satellit cell pectorali major p major muscl wk old commerci fast grow bird nichola turkey nct slower grow research line randombr control line rbc prolifer h c differenti h c cold c hot c control gene express among thermal treatment turkey line examin rnaseq detect signific differenti express gene deg cold treatment result signific gene express chang scs turkey line primari effect regul deg overrepresent gene involv regul skelet muscl tissu regener sarcomer organ heat stress increas express gene report regul myoblast differenti surviv promot cell adhes particular nct line result suggest growth select turkey alter development potenti scs commerci bird increas hypertroph potenti p major muscl sarcomer assembl biolog scs may account distinct differ outcom respons thermal challeng breast muscl growth develop structur turkey
|
D014422;D032496
|
T025;T012
|
36,292,740
|
posttranspl complic genet loci involv telomer mainten heart transplant patient reach critic short telomer induc cellular senesc ultim cell death cellular senesc contribut loss tissu function aim determin associ variant within gene involv telomer length mainten posttranspl event aortic telomer length heart transplant patient dna isol pair aortic sampl heart recipi age year correspond donor age year variant within terc rs terfip rs rs obcf rs gene genotyp telomer length measur use qpcr identifi similar frequenc genotyp heart donor recipi antibodi mediat reject amr common p lt carrier least one g allel within terfip locus rs chronic graft dysfunct cgd associ terc rs gg donor genotyp p genet risk score determin posttranspl complic risk predict associ analyz polymorph telomer length detect either donor recipi dna conclus possibl associ donor terfip rs amr terc rs cgd found snps within examin gene associ telomer length transplant patient
|
D016615;D016027
|
T026;T061
|
36,292,739
|
exploit compar omic understand pathogen virul associ proteas anti proteas relationship zoonot parasit fasciola hepatica fasciola gigantica helminth parasit fasciola hepatica fasciola gigantica causat agent fasciolosi global econom import diseas peopl livestock proteas pivot array biolog process relat parasit develop feed immun evas virul therefor action requir strict regul parasit anti proteas proteas inhibitor interrog current public avail fasciola spp larg sequenc dataset includ sever genom assembl life cycl stage specif transcriptom proteom dataset reveal complex profil structur proteas anti proteas famili oper various stage parasit life cycl moreov discov distinct profil peptidas cognat inhibitor express parasit stage intermedi snail host reflect differ environment nich move develop extract nutrient compar genom reveal similar cohort peptidas inhibitor f hepatica f gigantica surpris reduc number cathepsin peptidas gene f gigantica genom assembl chromosom locat f gigantica gene provid new insight evolut gene famili critic data futur analysi interrog fasciola spp hybrid spread throughout asian african contin
|
D005209;D005210;D010271
|
T204
|
36,292,738
|
enrich pathway calcium regul cellularoxid stress inflamm cell prolifer character gluteal muscl standardbr hors episod recurr exert rhabdomyolysi certain standardbr racehors develop recurr exert rhabdomyolysi rer std unknown reason compar gluteal muscl histopatholog geneprotein express standardbr histori current experienc rhabdomyolysi n race train control n eight rer std matur fiber small intern myonuclei one nine histolog evid regener zero nine degener howev rer std versus control differenti express gene deg top three gene ontolog go enrich pathway upregul deg n inflammationimmun respons go term cell prolifer go term hypoxiaoxid stress go term calcium ion regul go term purin nucleotid metabol go term electron transport go term top three enrich go pathway regul deg n deg regul ryr sarcoplasm reticulum calcium store differenti express protein dep n n involv sarcomer dep electron transport metabol inflamm celloxid stress dep includ superoxid dismutas catalas depdeg includ sever cystein base antioxid conclus gluteal muscl rer suscept standardbr character perturb pathway calcium regul cellularoxid stress inflamm cellular regener week episod rhabdomyolysi could repres therapeut target
|
D006734;D012206;D012749
|
T047;T046
|
36,292,737
|
skelet remain soldier two world war identif health research memori issu caus mass disast claim live ten thousand soldier countri around world two great war left lost miss franc corps resid legal vagu belong neither forens anthropolog archeolog nevertheless process identif determin caus death requir use modern forens anthropolog appli biolog profil dna analysi new genom method also provid insight health status militari popul provid new perspect period humanitarian crisi
|
D000071298;D008889
|
T023;T097
|
36,292,736
|
dynam network biomark analysi reveal critic phase transit fruit ripen grapevin grapevin viti vinifera l fruit ripen complex biolog process involv phase transit immatur matur understand molecular mechan fruit ripen critic grapevin fruit storag qualiti improv howev regulatori mechan critic phase transit fruit ripen immatur matur grapevin remain poor understood work identifi key molecular event control critic phase transit grapevin fruit ripen perform integr dynam network analysi time seri transcriptom data grapevin berri develop ripen result identifi third time point critic transit point grapevin fruit ripen consist onset veraison report previous studi addit detect gene key regul involv control fruit ripen go gene ontolog analysi show gene particip fruit develop seed develop studi provid dynam network biomark mark initi transcript event character transit process fruit ripen well new insight fruit develop ripen
|
D005638;D027843
|
T129;T168;T116;T002
|
36,292,735
|
clinic genet studi first monozygot twin pfeiffer syndrom object report clinic radiograph find molecular etiolog first monozygot twin affect pfeiffer syndrom method clinic radiograph examin whole exom sequenc perform two monozygot twin pfeiffer syndrom result acceptor splice site mutat fgfr c gt g detect twin father twin share haplotyp indic mutant allel father chromosom suffer sever upper airway obstruct subsequ obstruct sleep apnea hypertrophi nasal turbin appear newli recogn find pfeiffer syndrom increas intracrani pressur twin correct earli fronto orbit advanc skull expans open osteotomi order prevent sever consequ increas intracrani pressur includ hydrocephalus bulg anterior fontanell diastasi sutur conclus twin carri fgfr mutat discord lambdoid synostosi midfac hypoplasia narrow nasal caviti hypertroph nasal turbin result sever upper airway obstruct subsequ obstruct sleep apnea twin hypertrophi nasal turbin appear newli recogn find pfeiffer syndrom fronto orbit advanc skull expans open osteotomi perform treat increas intracrani pressur twin first report monozygot twin pfeiffer syndrom
|
D000168;D020181;D000402
|
T019;T047;T046
|
36,292,734
|
comparison major gene mutat relat rifampicin isoniazid resist beij non beij strain mycobacterium tuberculosi systemat review bayesian meta analysi object beij strain mycobacterium tuberculosi mtb controversi present predomin genotyp drug resist rifampicin isoniazid compar non beij strain aim compar major gene mutat relat rifampicin isoniazid drug resist beij non beij genotyp extract best evid use evid base method improv servic tb control program base genet mtb method literatur search googl scholar pubm cnki databas data analysi conduct r softwar convent bayesian random effect model employ meta analysi combin examin public bias sensit result strain pool studi identifi beij strain non beij strain maximum minimum strain size respect mutat preval rpob katg inha oxyr ahpc beij strain respect non beij strain separ pool posterior valu mutat rpob confid interv ci time higher beij non beij strain valu katg ci time estim inha ci time higher non beij beij strain oxyr ahpc ci time princip pattern variant mutat four gene rpob sl katg st inha c gt oxyr ahpc intergen region conclus mutat rpob katg gene beij signific common non beij strain mtb suffici evid support preval mutat inha oxyr ahpc higher non beij beij strain provid refer basi clinic medic select
|
D007538;D009169
|
T121;T007;T109
|
36,292,733
|
run homozygos reveal reproduct trait hu sheep hu sheep famous breed taihu basin advantag non season estrus multipl fetus coars feed toler suitabl hous feed run homozygos roh found effect tool detect anim popul structur econom trait detect roh benefici reduc incid inbreed well identifi harm variant genom howev lack system report rumin previous studi roh sequenc hu sheep detect roh hu sheep calcul inbreed coeffici select gene hu sheep breed within roh island relev agricultur econom characterist compar characterist occurr snps hu sheep sheep breed also investig distribut frequenc snps within specif gene region hu sheep breed select breed specif gene furthermor perform compar genom transcriptom analysi human sheep breed identifi import reproduct relat gene way found signific snps map set interest candid gene relat product valu livestock fgf bmprb efnb micu gfra healthi characterist lgsn epha aloxb breed specif fgf sap micu result studi describ various product trait hu sheep genet perspect provid insight genet manag complementari understand hu sheep
|
D036389;D007178
|
T123;T040;T116
|
36,292,732
|
acadm frameshift variant cavali king charl spaniel medium chain acyl coa dehydrogenas defici year old male neuter cavali king charl spaniel ckcs present complex focal seizur prolong lethargi aim studi investig clinic sign metabol chang under genet defect blood urin organ acid analysi reveal increas medium chain fatti acid togeth clinic find suggest diagnosi medium chain acyl coa dehydrogenas mcad defici sequenc genom affect dog compar data control genom differ dog breed acadm gene encod mcad consid top function candid gene genet analysi reveal singl homozyg privat protein chang variant acadm affect dog variant xm cdelinsgttaattctcaatattgtctaagaattatg introduc prematur stop codon predict result truncat wild type mcad open read frame xp p thrilef target genotyp variant addit ckcs reveal variant allel frequenc twelv addit homozyg mutant dog acylcarnitin cc ratio elev fold homozyg mutant dog compar homozyg wild type dog base avail clinic biochem data togeth current knowledg human propos acadm frameshift variant causat variant mcad defici like contribut neurolog phenotyp index case test ckcs breed popul identifi acadm variant recommend prevent unintent breed dog mcad defici prospect studi warrant assess clinic consequ enzym defect
|
D018389;D008052
|
T045;T047;T086;T049
|
36,292,731
|
repair foci liquid phase separ evid limit respons dna doubl strand break dsb repair protein accumul damag site form membran less condens foci format foci disassembl within proper time window essenti genom integr howev membran less sub compart form maintain disassembl remain unclear recent sever studi across differ model organ propos dna repair foci form via liquid phase separ review discuss current research investig physic natur repair foci first present differ model condens propos literatur highlight criteria differenti second discuss evid liquid phase separ dna repair site limit model fulli describ structur form respons dna damag final discuss origin possibl function liquid phase separ dna repair process
|
D004268;D053903
|
T123;T116;T049
|
36,292,730
|
genet overlap analysi identifi share etiolog migrain headach type diabet migrain headach frequent co occur type diabet td suggest share aetiolog two condit use genom wide associ studi gwas data investig genet overlap causal relationship migrain headach td use linkag disequilibrium score regress ldsc found signific genet correl migrain td r g p headach td r g p use pairwis gwas gwas pw analysi identifi pleiotrop region migrain td pleiotrop region headach td cross trait snp meta analysi identifi novel snp loci p meta lt associ migrain td three novel snp loci associ headach td cross trait gene base overlap analysi identifi gene signific associ p gene base lt migrain td gene associ headach td gene ehmt slca plekha cfdp tmema chst bcar common also signific overlap gene nomin associ p gene base lt migrain td p binomi test headach td p binomi test mendelian randomis mr analys provid consist evid causal relationship migrain td howev found headach causal associ invers varianc weight ivw p ivw td find robust confirm comorbid migrain headach td share genet control biolog mechan contribut co occurr evid causal relationship headach td
|
D003924;D008881
|
T047
|
36,292,729
|
evalu matur gene express sheep oocyt embryo cultur media supplement marjoram origanum vulgar extract studi aim evalu effect marjoram extract oocyt matur gene express sheep oocyt embryo first experi studi effect extract antioxid improv vitro matur media use sheep oocyt oocyt matur tcm medium supplement gml marjoram extract control g hr matur estim gene express measur use qpcr second experi studi effect extract develop sheep embryo produc vitro fertil oocyt cultur sof medium supplement gml marjoram extract control g day gene express measur use qpcr result show marjoram extract improv nuclear matur blastocyst rate signific increas level gdf gene express matur oocyt treatment group increas express bcl egr gene observ blastocyst gml group conclud marjoram extract improv nuclear matur affect express gene sheep oocyt embryo
|
D031341
|
T168;T002
|
36,292,728
|
function evolut c subclass ch type zinc finger transcript factor poplar ch zinc finger ch zf transcript factor particip various aspect normal plant growth regul stress respons c ch zfs special subclass conserv protein contain two znf ch domain c ch zfs arabidopsi zat involv stress resist function howev limit inform c ch zfs populus trichocarpa ptrizat analyz function evolut c ch zfs eleven ptrizat identifi p trichocarpa classifi two subgroup protein structur conserv znf ch domain qalggh motif show high conserv evolut ptrizat p trichocarpa space two znf ch domain chromosom locat cis element impli origin protein function ptrizat furthermor gene express differ tissu stress treatment show function differenti ptrizat subgroup stress respons function analysi c ch zfs differ populus speci plant impli evolut differenti especi term stress resist cis element express pattern analysi interact protein impli function ptrizat bind stress relat gene involv gene regul via epigenet modif histon regul dna methyl ubiquitin etc result origin evolut ptrizat contribut understand function differenti c ch zfs p trichocarpa interact express result lay foundat function investig role biolog process populus
|
D000070580;D032107;D017360
|
T087;T002
|
36,292,727
|
fbn splice alter mutat marfan syndrom case report literatur review marfan syndrom mfs life threaten autosom domin genet disord connect tissu caus pathogen mutat fbn whole exom sequenc sanger sequenc perform identifi pathogen mutat transcript consequ splice alter mutat analyz via minigen assay revers transcript pcr identifi novel pathogen mutat cg gt c splice site exon fbn gene mfs pedigre mutat confirm caus two differ truncat transcript entir exon skip partial exon exclus also systemat summar previous report transcript studi pathogen splice alter mutat fbn gene investig clinic transcript consequ conclus report first time splice alter mutat fbn gene lead two abnorm transcript simultan
|
D008382
|
T047
|
36,292,726
|
function bbx gene famili multipl stress nicotiana tabacum b box bbx zinc finger transcript factor involv regul growth develop plant resist various stress studi ntbbx gene identifi divid five subgroup tobacco member subgroup similar characterist promot region ntbbx gene cis act element relat light respons hormon regul stress respons transcriptom analysi show ntbbx signific regul ntbbx ntbbx ntbbx ntbbx signific regul abiot stress ntbbx gene also respond infect ralstonia solanacearum ntbbx ntbbx ntbbx ntbbx show greatest respons stress ntbbx gene express various degre differ tissu research provid solid foundat studi biolog function ntbbx gene tobacco
|
D014026;D018506
|
T045;T002
|
36,292,725
|
chloroplast genom lichen photobiont trebouxiophycea sp dw phylogenet implic lichen symbiot associ alga fungi genet mechan symbiosi lichen influenc symbiosi size composit genom symbiot alga alway intrigu scientif question explor lichenologist howev limit data lichen genom therefor isol purifi lichen symbiot alga obtain singl strain trebouxiophycea sp dw obtain chloroplast genom inform next generat sequenc ngs chloroplast genom bp length gc content repetit sequenc length bp account total chloroplast genom simpl sequenc repeat mononucleotid repeat codon usag analysi show genom tend use codon end au compar length differ region trebouxiophycea genom found chang length exon intron intergen sequenc affect size genom trebouxiophycea unstabl chloroplast genom structur ir repeat lose evolut phylogenet analysi show trebouxiophycea paraphylet trebouxiophycea sp dw sister clade koliella longiseta pabia signiensi
|
D054628;D008011;D000460
|
T002;T028
|
36,292,724
|
python cluster analysi protocol gene express data set gene express snps data hold great potenti new understand diseas prognosi drug sensit toxic evalu cluster analysi use analyz data contain specif subgroup goal use data recogn meaning inform subgroup addit cluster investig help data reduct purpos expos hidden pattern generat hypothes regard relationship gene phenotyp cluster analysi could also use identifi bio marker yield comput predict model method use analyz microarray data profound influenc interpret result therefor basic understand comput tool necessari optim experiment design meaning data analysi manuscript provid analysi protocol effect analyz gene express data set k mean dbscan algorithm general protocol enabl analyz omic data identifi subset featur low redund high robust speed identif new bio marker pathway enrich analysi addit demonstr effect cluster analysi protocol analyz real data set geo databas final manuscript provid best practic tip overcom issu analysi omic data set unsupervis learn
|
D017821
|
T014
|
36,292,723
|
comprehens analysi krt combin immun infiltr predict breast cancer prognosi date studi conduct explor mechan krt correl express krt immun infiltr breast cancer brca tcga timer ualcan databas use analyz express prognost role epigenet variant possibl oncogen mechan krt brca result krt show higher express compar normal tissu brca addit epigenet variat krt includ gene alter mutat type site dna methyl rna modif phosphoryl show divers brca mechanist explor suggest il signal pathway estrogen respons might play essenti role regul krt moreov krt differ regulatori biolog function brca import express krt close relat immun infiltr combin two could effect predict overal surviv final nomogram base gene associ cancer immun cycl signatur could predict progress free interv construct evalu success conclus krt may play role occurr develop brca il signal pathway meanwhil krt combin immun infiltr evalu prognosi brca patient
|
D001943
|
T191
|
36,292,722
|
novel identifi necroptosi relat risk signatur prognosi predict immun infiltr indic acut myeloid leukemia patient aml rank second common type leukemia diagnos adult children necroptosi program inflammatori cell death form report innat immun effector microbi viral pathogen recent found play event role oncogenesi progress metastasi cancer studi design explor potenti valu necroptosi predict prognost optim current therapeut strategi aml patient collect transcriptom clinic data cancer genom atlas tcga genotyp tissu express gtex databas select necroptosi relat gene differenti signific prognost valu six gene ybx zbp cdc alk braf bnip incorpor generat risk model implement multivari cox regress signatur proven independ prognost predictor train valid cohort hazard ratio hrs ci ci respect moreov receiv oper characterist roc curv util quantifi predict perform signatur satisfi result shown area curv auc year year respect addit subtyp aml patient base risk signatur demonstr signific correl immun cell infiltr respons immunotherapi final incorpor risk signatur classic clinic featur establish nomogram may contribut improv clinic manag conclud studi identifi necroptosi relat signatur novel biomark improv risk stratif inform immunotherapi efficaci indic therapeut option target therapi
|
D000079302;D015470
|
T191;T043
|
36,292,721
|
mstn regulatori network mongolian hors muscl satellit cell reveal mirna interfer technolog myostatin mstn member transform growth factor superfamili inhibit activ muscl satellit cell howev role regulatori network mstn equin muscl cell well understood yet discov mstn knockdown signific reduc prolifer rate equin muscl satellit cell addit rna sequenc equin satellit cell transfect mstn interfer plasmid control plasmid analysi differenti express gene carri reveal mstn regulatori network main involv gene relat muscl function cell cycl regul signal pathway notch mapk wnt subsequ real time pcr equin satellit cell immunohistochemistri newborn adult muscl also verifi mstn regulatori network found rna sequenc analysi result studi provid new insight regulatori mechan equin mstn
|
D055435;D035683
|
T123;T116;T114
|
36,292,720
|
clinic biochem molecular character two famili novel mutat ldha gene gsd xi lactat dehydrogenas ldh catalyz revers convers l lactat pyruv ldh defici autosom recess disord glycogenosi type xi omim caus mutat ldha gene present two young adult femal patient present intoler anaerob exercis episod rhabdomyolysi one patient psoriasi like dermat identifi ldha gene homozyg cc gt substitut predict pserter nonsens mutat patient one compound heterozyg cc gt pserter cg gt ptrpter nonsens mutat patient two pathogen variant demonstr electrophoret separ ldh isoenzym moreov flat lactat curv forearm exercis test along clinic combin myopathi psoriat like dermat also lead diagnosi
|
D006008;D003872
|
T047
|
36,292,719
|
identif analysi immun relat gene signatur hepatocellular carcinoma hepatocellular carcinoma hcc origin hepatocyt account liver cancer studi intend identifi novel prognost biomark predict prognosi hcc patient base tcga gse cohort
|
D006528;D008113
|
T191
|
36,292,718
|
genet genom research sweet potato sustain food nutrit secur food secur main challeng develop world especi least develop countri
|
D027723
|
T168;T002
|
36,292,717
|
pharmacogenet cannabi treatment chronic pain increas medic use cannabi reveal number benefici effect varieti advers side effect great inter individu variabl associ studi connect consumpt addict side effect relat recreat cannabi use led identif sever polymorph gene may play role pharmacodynam pharmacokinet cannabi
|
D059350;D002188;D006213
|
T184;T121;T109;T131;T002;T047;T167
|
36,292,716
|
advanc brain transcriptom advanc rna sequenc technolog past decad underlin power elucid brain gene network respons various stress factor well patholog associ genet determin neurodegen diseas acquir lifespan
|
D059467;D019636
|
T081;T047;T086
|
36,292,715
|
transcriptom analysi provid insight differenti effect aluminum peanut arachi hypogaea l acid soil high concentr aluminum ion al dissolv form reduc root growth develop crop addit al also benefici element plant speci low concentr howev regulatori mechan growth develop peanut arachi hypogaea l treat differ concentr al rare studi studi peanut seedl treat alcl h hoagland nutrient solut four differ concentr al ie ph ph ph ph mmoll regard al al al al result show low concentr al treatment al promot peanut growth high concentr al treatment al al signific inhibit peanut growth compar control al transcriptom analysi show differenti express gene deg starch sucros metabol pathway signific enrich low concentr ie al treatment wherea express aherd sugar transport signific regul solubl sugar content signific increas deg plant hormon signal transduct pathway signific enrich high concentr al al treatment wherea express ahnc cis epoxycarotenoid dioxygenas signific regul content aba signific increas moreov express transcript factor tfs peanut affect differ concentr al overal low concentr al promot peanut growth increas solubl sugar content high concentr al al inhibit growth peanut induc ahnc gene express increas endogen aba content peanut exposur al low concentr deriv adapt mechan cope al stress also act stimul promot growth develop
|
D010367;D000535
|
T121;T196;T002
|
36,292,714
|
genom wide identif character cct gene famili foxtail millet setaria italica respons diurnal rhythm abiot stress cct gene famili play import role diurnal rhythm abiot stress respons affect crop growth develop thus yield howev littl inform avail cct famili foxtail millet setaria italica present studi identifi putat sicct gene foxtail millet genom phylogenet tree construct predict full length sicct amino acid sequenc togeth cct protein rice arabidopsi repres monocotyledon dicotyledon plant respect base conserv structur phylogenet relationship sicct protein classifi col prr cmf subfamili respect gene structur protein conserv motif analysi exhibit high similar composit within subfamili whole genom duplic analysi indic segment duplic event play import role expans cct gene famili foxtail millet analysi transcriptom data show sicct gene signific diurnal rhythm oscil abiot stress exogen hormon treatment express mani cmf subfamili gene signific chang especi drought treatment express cmf subfamili gene except sicct signific regul work provid valuabl inform studi molecular mechan diurnal rhythm regul abiot stress respons identif candid gene foxtail millet molecular breed
|
D032983;D017360
|
T002
|
36,292,713
|
genet polymorph str loci western kazakh tribe kazakhstan karakalpakstan uzbekistan data genet polymorph str kazakh junior zhuz present analyz relat forens featur total repres western kazakh tribe kazakhstan western kazakh n uzbekistan karakalpakstan kazakh n examin yfiler plus set data avail yhrd access number ya ya genet analysi amova mds show signific differ two group kazakhstan karakalpakstan kazakh term chromosom divers group character haplogroup caa founder effect domin two three tribe alimuli baiuli zhetiru time phylogenet network tribe found cluster within caa western kazakh karakalpakstan kazakh present high valu uniqu haplotyp discrimin capac haplotyp divers set str loci distinguish close relat individu within western kazakh tribe quit well suitabl forens applic also optim popul genet studi
|
D041322;D018895
|
T026;T123;T114
|
36,292,712
|
deciph key regulatori role klf bta mir milk fat metabol bovin mammari epitheli cell microrna mirna non code rnas regul express target gene involv mani cellular function post transcript level previous bta mir show signific high express bovin mammari epitheli cell bmec chines holstein cow produc high milk fat compar low milk fat content investig role bta mir target krppel like factor klf analyz role klf regul fat metabol target ppara ampkmtorpparg fat marker gene bmec chines holstein bioinformat analysi show utr klf mrna possess bind site bta mir verifi dual luciferas report assay bmec transfect bta mir mimic inhibitor shnc express klf found negat regul bta mir moreov content triglycerid tg cholesterol cho bmec transfect bta mir mimic signific lower content bmec transfect bta mir shnc meanwhil tg cho content signific increas bmec transfect bta mir inhibitor bmec transfect bta mir shnc addit tg cho content signific decreas bmec upon regul klf transfect pbsk klf sirna compar control group contrarili klf overexpress bmec transfect pbi cmv klf tg cho content signific increas compar control group wherea qpcr western blot evalu ppara ampkmtorpparg fat marker gene reveal gene consider regul klf ko bmec compar normal bmec take advantag deploy new molecular marker regul increas product better qualiti milk tailor fat content would hallmark dairi sector henc bta mir klf potenti candid increas milk synthesi product valuabl milk compon dairi cattl marker assist select molecular breed furthermor studi hint extrapol myriad function klf famili member milk fat synthesi
|
D008892;D035683
|
T168;T123;T114;T031
|
36,292,711
|
compar genom approach analysi complet mitogenom five actinidiacea plant actinidiacea econom import plant famili includ actinidia clematoclethra saurauia genus kiwifruit remark high vitamin c content endem speci wide distribut china high econom valu although mani actinidiacea chloroplast genom report complet mitogenom actinidiacea studi complet circular mitogenom four kiwifruit speci saurauia tristyla assembl codon usag sequenc repeat rna edit gene transfer select pressur phylogenet relationship four kiwifruit speci tristyla compar analyz research contribut studi phylogenet relationship within actiniacea molecular barcod kiwifruit
|
D029041;D054629;D029042
|
T028;T002
|
36,292,710
|
current analyt method research trend use identifi domest pig wild boar dna meat meat product pig one import livestock speci meaning sourc global meat product necessari howev prove whether food product discern custom select store actual made pork venison contain problem food authent widespread worldwid case meat adulter acceler develop food identif method feed speci worth note sever differ molecular biolog techniqu identifi porcin compon howev precis differenti wild boar domest pig meat product still challeng paper present current state knowledg concern speci identif domest pig wild boar dna meat product
|
D034421;D008461
|
T168;T015
|
36,292,709
|
regul gene relat cognit tdcs intermitt hypox brain injuri rat model background hypox brain injuri condit caus restrict oxygen suppli brain sever studi report cognit declin particular spatial memori exposur intermitt hypoxia ih howev effect mechan action ih exposur cognit evalu analyz gene express transcrani direct current stimul tdcs henc purpos studi investig effect tdcs gene regul cognit rat model ih induc brain injuri method twenti four week old male spragu dawley rat divid two group ih expos rat stimul ih expos rat receiv tdcs rat expos hypox chamber contain oxygen twelv hour day five day stimul group receiv tdcs intens frontal bregma area min day week behavior test escap latenc morri water maze mwm test measur assess spatial memori stimul seven day stimul gene microarray analysi conduct kegg mapper tool result although signific differ group stimul signific effect time signific time group interact escap latenc microarray analysi signific fold chang gene relat neurogenesi found stimul group tdcs p lt fold chang gt time averag normal read count rc gt time high upregul gene stimul group tdcs sos raf pik rac irak bax high downregul gene stimul group tdcs chk crk rap p ras nf k b conclus studi confirm sos raf pik rac irak bax upregul chk crk rap p ras nf k b downregul rat model ih induc brain injuri applic tdcs
|
D065908;D001930
|
T061;T037
|
36,292,708
|
new genet biomark overlap syndrom tension type headach arteri hypertens nitric oxid import autocrin paracrin signal molecul play crucial role cardiovascular physiolog patholog regul import molecul involv regul cerebr extra cerebr cranial blood flow arteri diamet reduc bioavail endothelium import precursor impair vasodil arteri hypertens ah furthermor involv nocicept process induc biphas respons immedi delay headach typic chronic tension type headach tth human aim studi associ allel variant genotyp singl nucleotid variant snv rs nos gene tth ah overlap syndrom develop middl age adult
|
D018781;D006973
|
T047
|
36,292,707
|
spatial tempor express characterist hbb gene famili six differ pig breed thalassemia induc hemolyt anemia caus mutat chain gene locus human progress embryo adulthood hemoglobin recombin twice test whether similar hemoglobin reassembl occur pig bioinformat tool use predict pig hemoglobin encod gene systemat analyz express pattern hbb gene famili three development stage wean sexual matur physic matur six differ pig breed landrac yorkshir wuzhishan songliao black meishan tibetan result show new hemoglobin code gene hbb like found pig hbg gene exist pig indic human like reassembl might exist pig hbb hbb like gene share high similar amino acid sequenc gene sequenc gene chain high similar human pig amino acid sequenc human pig hbb gene posit posit ident qpcr result show signific differ spatiotempor express pattern four gene hba hbb hbb like hbe across breed result provid foundat follow studi assess relationship gene encod hemoglobin thalassemia diseas well construct gene edit thalassemia miniatur pig model assess thalassemia treatment
|
D055544;D017086
|
T123;T047;T116
|
36,292,706
|
autism epilepsi neuropsychopharmacolog updat associ autism spectrum disord asd epilepsi extens document estim preval vari depend upon select popul clinic characterist current lack studi assess patient care pathway asd particular comorbid epilepsi despit person famili econom impact genet abnorm like implic associ asd epilepsi although current detect small percentag patient known genet medic condit associ asd epilepsi specif seizur type expect children adolesc asd compar neurodevelopment disord epilept syndrom treatment option includ antiepilept drug a development base earli intervent asd carbamazepin lamotrigin use a studi need precis defin suitabl medic specif group children asd
|
D001321;D004827
|
T033;T047;T048
|
36,292,705
|
altern splice human physiolog diseas sinc discoveri altern splice late great number altern splice transcript emerg number exponenti increas advanc transcriptom massiv parallel sequenc technolog
|
D017398;D059467
|
T123;T045;T114;T081;T086
|
36,292,704
|
project express profil transcript factor activ space provid ad inform acut myeloid leukemia aml aggress type leukemia character accumul high prolif blast disrupt myeloid differenti program current treatment ineffect patient part due genet heterogen aml driven genet distinct leukemia stem cell result relaps even tumor cell destroy thus person treatment approach address cellular heterogen urgent requir reconstruct transcript regulatori network rtn tool infer transcript activ patient various diseas studi appli method transcriptom profil aml patient test provid addit inform interpret transcriptom data show rtn result ad rna seq result superior cluster form homogen allow better separ patient low high surviv rate conclud extern knowledg use rtn analysi improv abil unsupervis machin learn find meaning pattern data
|
D015470
|
T191
|
36,292,703
|
kata ef promot cell prolifer migrat via upregul express ubec pan cancer various studi shown lysin acetyltransferas kata ef transcript factor ef ubiquitin conjug enzym e c ubec gene regul prolifer migrat tumor cell regul cell cycl howev lack depth systemat research mechan action studi analyz cancer genom atlas tcga screen potenti candid gene regul network kata ef complex pan cancer quantit real time pcr qrt pcr western blot wb cell phenotyp detect immunofluoresc co local chromatin immunoprecipit assay chip rna seq techniqu use explor function candid gene ubec found express three gene signific higher tumor type compar normal tissu moreov ubec main express tumor cell highlight impact ubec specif therapeut strategi moreov kata ef could promot cell prolifer migrat cancer cell enhanc express ubec mechan kata found cooper ef recruit ef ubec promot elev express ubec increas acetyl level hk
|
D000070837;D009369
|
T191;T126;T116
|
36,292,702
|
bioinformat identif aberr methyl differenti express gene associ arteriosclerosi integr analysi gene express dna methyl dataset prognosi patient advanc arteriosclerosi bleak due lack understand arteriosclerosi epigenet base dna methyl play import role pathogenesi arteriosclerosi henc aim identifi epigenet relat aberr methyl differenti express gene amdeg arteriosclerosi gene express dataset dna methyl dataset download gene express omnibus databas amdeg identifi basi relationship methyl express subsequ express level candid hub gene detect human peripher blood mononuclear cell pbmcs atherosclerot patient control subject rt qpcr western blot last methyl level target gene detect use massarray method present studi hypermethyl downregul gene main involv vascular smooth muscl contract hypomethyl upregul gene mark associ immun inflammatori process follow valid lmod identifi target gene hypermethyl downregul arteriosclerosi methyl level cpg site lmod promot detect elev pbmcs atherosclerot patient conclus amdeg identifi present studi may assist understand pathogenesi arteriosclerosi lmod exhibit potenti promis diagnost therapeut biomark arteriosclerosi
|
D019175;D001161
|
T047;T044
|
36,292,701
|
effect combin methamphetamin oxycodon use synapt proteom vitro model polysubst use polysubst use psu general involv simultan use opioid along stimul recent year problem escal nationwid epidem understand mechan effect under interact drug essenti develop treatment suffer addict current effect psu synaps critic point contact neuron remain poor understood use vitro model primari neuron examin combin effect psychostimul methamphetamin meth prescript opioid oxycodon oxi synapt proteom use quantit mass spectrometri base proteom cluego analysi ingenu pathway analysi ipa indic dysregul sever molecular function biolog process pathway associ neural plastic structur develop identifi one key synapt protein striatin play vital role mani process function downregul follow methoxi treatment downregul striatin valid western blot overal present studi indic sever damag effect combin use meth oxi neural function warrant detail investig mechan contribut synapt dysfunct
|
D008694;D000697
|
T121;T131;T109
|
36,292,700
|
establish effici vitro propag cnidium officinal makino select superior clone flow cytometr assess dna content cnidium officinal valuabl medicin plant cultiv asia rhizom studi report vitro regener cnidium officinal plant induct rhizom microshoot rhizomat bud cnidium officinal induc multipl shoot murashig skoog ms medium supplement mg l ba led regener plant within four week cultur four week cultur plant assess fresh weight number leav number root length root compar perform differ clone clone good growth characterist select aid flow cytometr analysi c nuclear dna content plant bear high dna valu show better growth characterist various factor name sucros concentr g l aba mg l synergist effect ba mg l naa mg l ba mg l naa mg l aba mg l without activ charcoal g l light dark incub test rhizom format microshoot result experi suggest ms medium supplement g l sucros mg l aba g l ac good induct rhizom shoot cnidium officinal plantlet rhizom success transfer pot show surviv
|
D031048;D010937
|
T125;T116;T002
|
36,292,699
|
risk factor thorac aortic dissect thorac aortic aneurysm involv root andor ascend aorta enlarg time acut tear intim layer lead high fatal condit acut aortic dissect aad stanford type aad tear occur sinotubular junction lead format fals lumen aortic wall may extend arch thoracoabdomin aorta type b aad origin descend thorac aorta distal left subclavian arteri genet variant various environment condit disrupt aortic wall integr identifi increas risk thorac aortic aneurysm dissect tad review discuss predomin tad associ risk factor focus primarili non genet factor discuss under mechan lead tad
|
D017545;D000784
|
T047;T046
|
36,292,698
|
express activ artifici promot diseas resist transgen eucalyptus urophylla transcript properti artifici promot close relat type arrang posit cis element gwsf bp effect spip four cis element dimer four pathogen induc cis element gwsf promot gst box w box box f box minim cauliflow mosaic virus promot v element dimer insert upstream vgwsf midstream gwvsf downstream gwsfv region origin gwsf promot sequenc examin affect posit express activ promot analyz estim use histochem stain leaf disc eucalyptus transient express imag digit method extract color featur induct treatment plant pathogen microorganisminduc qpcr assay histochem stain result adventiti bud indic promot success integr e urophylla genom drove express gus gene notic differ intens color adventiti bud callus block well intens color within adventiti bud accord establish two factor model blue valu greater differ level genotyp factor promot factor eucalyptus leaf disc basal induc transcript level three improv promot investig qpcr basal transcript level gwsf promot normal one relat basal level vgwsf gwvsf gwsfv respect qpcr result consist stain result gus histochem stain three improv promot properti induc salicyl acid ralstonia solanacearum phytophthora capsici three improv promot demonstr signific higher tmv induct activ induct activ high low gwsfv gt gwvsf gt vgwsf find benefici construct optim artifici promot transgen plant
|
D060467;D005052
|
T040;T002
|
36,292,697
|
transcriptom analysi provid insight copul fertil gestat sebast schlegelii among vivipar marin teleost china black rockfish sebast schlegelii hilgendorf one econom import addit copul intern fertil featur lengthi sperm storag femal ovari well high rate abort network gene regul necessari process elucid mechan copul fertil gestat essenti determin genet basi vivipar teleost oogenesi embryogenesi studi analyz transcriptom ovari differ development phase investig dynam chang occur construct ovari transcriptom order investig regul embryogenesi differenti express gene deg specif express pattern subject gene ontolog annot pathway analys weight gene co express network analysi wgcna regul gene signific enrich focal adhes regul actin cytoskeleton wnt ecm receptor interact signal pathway result studi provid omic evid copul fertil gestat vivipar marin teleost decod schlegelii gene regul network well provid new insight embryogenesi high valuabl research marin teleost reproduct scienc
|
D003307;D010473
|
T054;T013
|
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