PMID
int64 35.7M
36.4M
| Title/Abstract
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101
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36,292,696
|
pyunbbx involv regul anthocyanin biosynthesi uv b stress background populus yunnanensi dode p yunnanensi grow low latitud high altitud area southwest china low latitud high altitud area plant suffer high intens uv b ultraviolet b radiat complet regul system adapt environ high uv b radiat natur antioxid anthocyanin play import role scaveng free radic bbx b box gene involv anthocyanin biosynthesi method explor gene structur motif pyunbbx gene gene p yunnanensi bbx famili evolutionari relationship pyunbbx gene speci bbx gene six pyunbbx gene respond uv b particip anthocyanin biosynthesi screen bbx potenti regul anthocyanin biosynthesi investig anthocyanin content determin rt qpcr real time quantit polymeras chain reaction result day uv b treatment anthocyanin signific accumul express pyunbbx regul day express pyunbbx inhibit uv b treatment analyz rna seq data leav bark p yunnanensi found pyunbbx high express leav young bark conclus result show pyunbbx pyunbbx may involv respons process uv b stress pyunbbx may regul anthocyanin biosynthesi resist uv damag
|
D000872;D032107
|
T121;T002;T109
|
36,292,695
|
basement membran relat gene signatur predict prognosi grade iiiii glioma glioma classifi grade ii grade iii lesion world health organ high aggress may develop glioblastoma within short period thus portend conferr poor prognosi patient previous studi implic basement membran bm relat gene glioma develop studi construct prognost model grade iiiii glioma accord risk score bm relat gene differenti express gene deg glioma sampl relat normal sampl screen geo databas five prognost relev bm relat gene includ nell unca tnc cspg smoc select use cox regress analys risk score model median risk score calcul base high low risk group patient generat clinic inform patholog inform risk group combin establish prognost nomogram nomogram risk score model perform well independ cgga cohort gene set enrich analysi gsea immun profil drug sensit tumor mutat burden tmb analys perform two risk group signific enrich autophagi collect duct acid secret glycosphingolipid biosynthesi lacto neolacto seri valin leucin isoleucin degrad vibrio cholera infect pathway observ patient high risk addit higher proport monocyt rest cd memori cell observ low high risk group respect conclus bm relat gene risk score model guid clinic manag grade ii iii glioma
|
D007532;D005910
|
T123;T121;T191;T116
|
36,292,694
|
clinic cours genet immunohistochem character solid pseudopapillari tumor pancrea frantz tumor brazilian cohort frantz tumor solid pseudopapillari pancreat neoplasm spn rare exocrin neoplasm carri favor prognosi repres tumor locat region pancrea specif age gender predisposit recent year rise curv diagnosi entitl evolut access diagnost imag paper retrospect review describ clinic cours patient spn three institut brazil diagnosi analyz clinicopatholog genet surgic aspect individu accord literatur patient women unspecifi symptom diagnosi tumor main locat bodi tail pancrea underw distal pancreatectomi spare splenectomi standard procedur none case experienc recurr date surgeri still remain mainstay treatment given low metastat potenti conserv approach observ cohort evolv becom standard care herein present depth analysi case focus latest literatur report smallest tumor case literatur knowledg first report evalu germlin genet test present case detect li fraumeni syndrom
|
D010190
|
T191
|
36,292,693
|
genom wide associ studi imput whole genom sequenc data identifi kb risk haplotyp cfa congenit laryng paralysi alaskan sled dog congenit laryng paralysi clp inherit disord affect abil dog exercis preclud function work sled dog though clp known occur alaskan sled dog asd sinc genet mutat under diseas report use genom wide associ studi gwas identifi kb region cfa harbor snps signific associ clp signific snps explain herit clp narrow region kb autozygos map found case homozyg risk haplotyp whole genom sequenc two case control asd comparison genom dog various breed confirm homozyg status risk haplotyp uniqu clp case dog homozyg risk allel blue eye gene annot gene base associ studi show risk haplotyp encompass gene implic development neurodegen disord pathway analysi show enrich glycoprotein glycosaminoglycan biosynthesi play key role repair damag nerv conclus result suggest import role identifi candid region clp
|
D014826;D004283
|
T033;T047
|
36,292,692
|
develop snp marker gwas select seed coat aleuron layer brown rice oryza sativa l nineti five percent general nutrient rice concentr rice bran germ mani nutrient vitamin miner dietari fiber essenti fatti acid well antioxid tocopherol lost mill studi investig thick seed coat aleuron layer use rice core collect found candid gene relat thick seed coat aleuron layer perform genom wide associ studi gwas analysi use whole genom resequenc data two primer pair use high resolut melt hrm marker develop result genotyp bc f individu deriv cross samgwang seolgaeng use correspond hrm marker possibl final develop hrm marker select seed coat aleuron layer thick expect use basic data applic gene edit use crisprca technolog establish breed strategi high eat qualiti rice use molecular genet technolog
|
D012275
|
T168;T002
|
36,292,691
|
identif registr high yield strain st mlt curcuma caesia roxb jor lab kh high valu medicin plant background curcuma caesia roxb high valu crop extens use pharmaceut flavour fragranc c caesia recognis endang speci due extens collect wild human intervent therefor prevent speci extinct necessari conserv cultiv plant speci sustain avail raw materi method present plant breed programm multi year studi perform identif superior genotyp help conserv fulfil object total access c caesia collect differ region india set experiment select trial three year proper evalu genotyp base six agronom trait five high yield genotyp identifi underw multiloc trial two year stabil analysi use eberhart russel method ammi gge biplot use studi consist genotyp vari environ compar check varieti result analysi varianc indic signific genotyp environ interact yield trait ie dri rhizom recoveri rhizom yield essenti oil yield coeffici variat cv highest tiller per plant lowest plant height result clear demonstr jor lab kh highest yield stabl genotyp vari environ compar check varieti select genotyp conclus genotyp submit icar nbpgr new delhi germplasm registr receiv confirm vide registr number ingr genotyp great benefit breeder also help conserv endang speci first report identif registr high yield varieti c caesia
|
D010946;D009822
|
T002;T109
|
36,292,690
|
dna barcod speci classif morchella true morel morchella well known edibl fungi econom medicin import valu howev molecular identif speci taxonomi genus morchella long controversi due numer intermedi morpholog among speci studi determin identif effici dna barcod speci classif individu morchella speci basi multipl nuclear dna marker dna barcod analysi show individu dna fragment lower resolut speci identif combin multipl dna marker show highest level speci discrimin among individu genet marker interest combin dna marker signific increas resolut speci identif combin four dna gene ef rpb rpb show higher speci delimit combin two three marker phylogenet analysi suggest speci genus morchella could divid two larg genet clade elata clade esculenta clade lineag two lineag divid approxim mya hpd interv earli cretac period howev phylogenet speci morchella show inconsist evolutionari relationship tradit morpholog classif may result incomplet lineag sort andor introgress hybrid among speci find demonstr interspecif gene introgress may affect speci identif true morel combin dna marker signific improv resolut speci discrimin
|
D058893;D001203
|
T062;T087;T004
|
36,292,689
|
effect exogen k potassium applic plant hormon root tamarix ramosissima nacl stress abiot stress salt stress serious affect growth yield plant tamarix ramosissima lcdcb ramosissima wide cultiv halophyt salin alkali area world essenti element plant growth develop k play irreplac role improv toler plant salt stress howev report mechan k promot plant hormon reduc damag nacl stress ramosissima studi sequenc transcriptom root ramosissima treat exogen potassium k h h h nacl stress accord chang express level differenti express gene deg ramosissima root key candid gene metabol pathway relat plant hormon mine analysi verifi quantit real time pcr qrt pcr result show nacl stress h h larg number deg root ramosissima express level chang time particular found plant hormon relat gene annot kyoto encyclopedia gene genom kegg pathway increas time express level main regul involv relat metabol pathway resist nacl stress worth note deg relat abscis acid aba deg relat auxin deg relat ethylen et deg relat cytokinin ck ad within h exogen potassium involv allevi root damag ramosissima nacl stress play import role addit found plant hormon signal transduct pathway play import role resist nacl stress result studi molecular mechan plant hormon involv appli exogen potassium nacl stress understood result better understand exogen potassium allevi damag caus nacl stress ramosissima
|
D032363
|
T002
|
36,292,688
|
particip choic toward receiv potenti addit find australian nephrolog research genom studi choic particip nephrolog research genom studi receiv addit find af unclear particip factor might influenc choic method particip choic factor potenti impact decis af examin australian studi appli research genom test follow uninform diagnost genet test suspect monogen kidney diseas result particip chose receiv potenti af statist signific differ consent receiv af term gender p median age p person affect inherit kidney diseas interest p inherit pattern p particip like choos receiv af famili proband present adulthood p famili histori anoth genet disord p consent process undertaken adult nephrologist p conclus major particip nephrolog research genom studi chose receiv potenti af younger age famili proband famili histori altern genet disord consent multidisciplinari team member might impact upon particip choic
|
D009398;D007674
|
T047;T091
|
36,292,687
|
research werner syndrom trend past present futur prospect rare autosom recess prematur age disord werner syndrom ws character earli onset age associ diseas includ shorten statur alopecia bilater cataract skin ulcer diabet osteoporosi arteriosclerosi chromosom instabl well cancer predisposit wrn gene respons ws encod dna helicas exonucleas activ numer studi reveal wrn helicas involv mainten chromosom stabil action dna eg dna replic repair recombin epigenet regul via interact dna repair factor telomer bind protein histon modif enzym dna metabol factor howev although effort elucid cellular function helicas cell line link treatment diseas life expect improv ws patient past three decad hope fundament treatment diseas develop diseas specif induc pluripot stem ip cell establish expect use drug discoveri regen medicin ws patient articl review trend research date present perspect ws research regard applic pluripot stem cell furthermor elucid diseas mechan drug discoveri util vast amount scientif data accumul date discuss
|
D014898
|
T047
|
36,292,686
|
parent report social communic skill children q copi number variant sibl q delet qds q duplic qdup confer risk neurodevelopment difficulti character speech languag social skill qdup still limit therefor studi aim delin social communic skill school age children qdup n compar non carrier sibl n age match children qds n parent complet two standard questionnair children communic checklist ccc screen speech languag social skill social respons scale srs assess deficit social behavior parent report children qdup qds show social communic deficit general popul children qdup seem take intermedi posit sibl children qds compar qds demonstr less frequent less sever problem heterogen social communic profil fewer restrict interest repetit behavior sibl qdup milder social communic difficulti equal heterogen profil report might indic addit duplic factor broader genet context play role social communic outcom
|
D004062
|
T047
|
36,292,685
|
influenc parent origin intellectu outcom chromosom q delet syndrom learn intellectu disabl hallmark featur q delet syndrom data limit howev regard influenc full scale iq fsiq investig possibl q delet parent origin effect individu compar fsiq de novo inherit q delet subset data avail examin parent origin effect fsiq use linear regress model account covari median fsiq signific higher de novo vs inherit delet rang vs rang p lt result remain signific use regress model account age iq test sex cohort site signific parent origin differ fsiq observ de novo delet n matern p howev median fsiq signific lower matern patern inherit famili delet rang vs rang respect p regress model indic point decrement fsiq variabl p fsiq higher averag de novo inherit q delet regardless parent origin howev parent origin appear relev inherit delet result potenti clinic implic research need delin possibl action mechan
|
D004062;D008607
|
T047;T048
|
36,292,684
|
evolutionari diverg toona ciliata toona sinensi assay whole genom sequenc toona ciliata toona sinensi belong toona genus meliacea famili import timber speci china ciliata endang speci level ii due overcut low rate natur regener sinensi cultiv econom nutriti tree year two speci differ flower leaf morpholog trait reproduct system rang size natur distribut reveal potenti molecular basi diverg examin similar differ whole genom sequenc result indic ciliata higher number expand gene famili sinensi whole genom duplic wgd occur speciat long termin repeat ltrs insert earlier ciliata genom mya sinensi genom mya twenti five gene famili ciliata genom detect posit select compar background branch ten differ land speci ciliata genom high collinear sinensi genom low collinear genom distant speci genom evolutionari diverg potenti associ differ ciliata sinensi term reproduct system ecolog adapt
|
D000082982;D029582
|
T002
|
36,292,683
|
robust genet analysi x link anophthalm ie mous anophthalmia miss eye describ failur earli embryon ocular develop mutat relat small set gene account bilater anophthalmia case yet famili current left without molecular diagnosi report experiment work aim uncov development genet basi anophthalmia characteris x link ie eye ear reduct x ray induc allel mous first identifi histolog analysi embryon phenotyp show failur normal eye develop optic vesicl stage particular sever malform ventral retina linkag analysi map mutat mb region x chromosom short long read whole genom sequenc wgs affect unaffect male litterm confirm ie linkag identifi plausibl causat variant structur rearrang analys reduc critic candid interv reveal evid multipl variant within ancestr dna although none found alter code sequenc uniqu ie investig earli embryon event genet level generat mous es cell deriv male ie embryo wild type litterm rna seq access chromatin sequenc atac seq data generat cultur optic vesicl organoid reveal larg differ gene express access putat cis regulatori element ie wild type howev unbias tf footprint analysi access chromatin region provid evid genom wide reduct bind transcript factor associ ventral eye develop ie evid increas bind zic famili transcript factor includ zic locat within ie refin critic interv conclud refin ie critic region chrx contain multipl genet variant may link alter cis regul contain convinc causat mutat chang bind key transcript factor chromatin caus alter gene express develop possibl subtl mis regul zic present plausibl caus anophthalmia phenotyp observ ie work requir determin precis causat allel genet mechan
|
D000853
|
T019
|
36,292,682
|
associ gene variant mechan metabol muscl qualiti cardiorespiratori muscular variabl relat perform ski athlet ski popular outdoor sport pose differ requir musculoskelet cardiorespiratori function excel competit extent genotyp featur contribut develop perform year ski specif train remain elucid therefor test whether promin polymorph gene angiotensin convert enzym ace id rs tenascin c tnc rs actinin actn rs ptk rs rs associ differenti cellular hallmark muscl metabol contract high level skier
|
D012865
|
T056
|
36,292,681
|
phenotyp impact rare potenti damag copi number variat obsess compuls disord chronic tic disord recent studi report import previous underestim role rare variat risk obsess compuls disord ocd chronic tic disord ctd use data larg epidemiolog studi evalu distribut potenti damag copi number variat pdcnv ocd ctd examin associ pdcnv phenotyp proband includ consider earli vs late diagnos
|
D005879;D000067877;D013981;D009771
|
T047;T037;T048
|
36,292,680
|
mitochondri trna gln c gt mutat may contribut clinic express gt g induc deaf mitochondri gt g mutat play critic role aminoglycosid induc non syndrom hear loss ainshl previous studi suggest mitochondri secondari variant may modul clinic express gt g induc deaf molecular mechan remain larg undetermin studi investig contribut deaf associ trna gln c gt mutat clinic express gt g mutat interest three generat famili gt g mc gt mutat exhibit higher penetr hear loss anoth famili harbor gt g mutat molecular level mc gt mutat resid within conserv nucleotid trna gln form new base pair may affect trna structur function use tran mitochondri cybrid cell deriv three subject gt g mc gt mutat three patient gt g mutat three control subject without primari mutat observ cell gt g mc gt mutat exhibit sever impair mitochondri function gt g mutat furthermor mark decreas mitochondri rna transcript respiratori chain enzym observ cell harbor gt g mc gt mutat thus data suggest mc gt mutat may play synergist role gt g mutat enhanc mitochondri dysfunct contribut high penetr hear loss famili mtdna pathogen mutat
|
D003638;D034381
|
T033;T184;T047
|
36,292,679
|
profil genom wide dna methyl children autism spectrum disord children fragil x syndrom autism spectrum disord asd earli onset development disord whose genet caus heterogen complex total asd case due unknown etiolog among monogen caus asd fragil x syndrom fxs account asd case individu fxs present asd epigenet chang specif dna methyl modul gene express level play signific role pathogenesi disord thus studi use human methyl epic bead chip examin global dna methyl profil biolog sampl deriv age match male particip year old includ subject asd subject fxs asd fxsa typic develop td children control technic variat white blood cell composit use conservatori threshold fals discoveri rate fdr three comparison group td vs ad td vs fxsa asd vs fxsa identifi differenti methyl site dms differenti methyl region dmrs interest sever gene differenti methyl among three group among list sfari gene databas includ pak gtfi foxp gene import brain develop enrich analys identifi pathway involv sever function includ synapt plastic preliminari studi identifi signific role alter dna methyl patholog asd fxs suggest character dna methyl signatur may help unravel pathogen fxs asd may help develop improv diagnost classif children asd fxsa addit may pave way develop therapeut intervent could revers alter methylom profil children neurodevelopment disord
|
D005600;D000067877;D019474
|
T123;T047;T116;T048
|
36,292,678
|
qtl map stem rust resist popul durum wheat stem rinfectionust caus fungus puccinia gramini f sp tritici pgt one devast fungal diseas durum common wheat worldwid identif sourc resist valid qtls identifi genom wide associ studi paramount import reduc loss caus diseas wheat grain yield qualiti four segreg popul whose parent show contrast reaction pgt race assess present studi qtls identifi chromosom b region common differ segreg popul sever qtls map chromosom region coincid previous map stem rust resist loci howev reaction differ pgt race suggest novel gene allel could present chromosom b putat candid gene diseas relat function annot identifi qtl region base inform avail refer genom durum cv svevo
|
D014908;D001487
|
T168;T004;T002
|
36,292,677
|
phenotyp spectrum molecular find atr x syndrom italian patient new insight atr x syndrom rare x link congenit disord caus hypomorph mutat atrx gene typic phenotyp well defin cognit impair characterist facial dysmorph hypotonia gastrointestin skelet urogenit hematolog anomali characterist featur notabl except general phenotyp differ relat specif atrx protein domain well establish use least present time prognost purpos phenotyp spectrum genotyp correl gradual broaden main due rapid increas access ngs scenario import continu describ new patient illustr mode age onset typic non typic featur classic one tentat ad recent report well character most unreport patient expand atr x clinic spectrum emphas import better clinic delin condit compar find largest atr x seri report far discuss possibl explan differ drawn conclus
|
D004265;D009687
|
T123;T126;T116
|
36,292,676
|
cistanch speci mitogenom suggest divers complex lamial order mitogenom extrem divers complex angiosperm well known despit fact parasit plant angiosperm littl known parasit plant mitogenom divers complex evolut studi obtain character mitogenom three cistanch speci holoparasit plant china compar repeat segment duplic multi copi protein code gene pcgs clarifi phylogenet evolut relationship within lamial order identifi mitochondri plastid insert mtpt cistanch mitogenom result show mitogenom size three cistanch speci rang bp cistanch speci genom encod gene includ pcgs trna gene rrna gene compar lamial parasit speci cistanch speci show extrem high rate multi copi pcgs rang percent total number pcgs addit simpl sequenc repeat ssrs found three mitogenom major mononucleotid adeninethymin interspers repeat contain forward palindrom repeat furthermor segment duplic sequenc size rang bp account cistanch deserticola cistanch salsa cistanch tubulosa mitogenom respect furthermor kak analysi suggest atp ccmb ccmfc matr probabl posit select lamial evolut cistanch plastom suggest presenc mtpt moreov trna pcgs fragment rrna gene fragment cistanch mitogenom found mtpt region work report cistanch speci mitogenom first time invalu studi mitogenom evolut orobanchacea famili
|
D054629;D031671;D000068378
|
T002;T028
|
36,292,675
|
genet divers popul structur hemicult leucisculus basileski xinjiang tarim river hemicult leucisculus invas fish wide distribut xinjiang tarim river studi rad seq use explor genet divers popul subgroup structur h leucisculus tarim river develop relev simpl sequenc repeat ssr marker studi collect sampl distribut four differ site tarim river total singl nucleotid polymorph snps obtain genet divers result show popul genet divers level h leucisculus low popul pairwis f st valu rang indic moder genet differenti among popul amova show genet variat within popul account total variat princip compon analysi pca neighbor join nj tree reveal four popul could separ two cluster upper middl downstream popul individu taitema lake ttmh show differ bigger geograph distanc other probabl h leucisculus bosten lake enter taitema lake breed expand tarim river due water divers project locat addit ssrs loci detect ssr primer pair develop studi contribut provid valuabl molecular data manag wild popul marker assist select resourc exploit h leucisculus
|
D018895;D003531
|
T123;T114;T013
|
36,292,674
|
mitochondria dna variat biomark ad alzheim diseas ad preval form dementia character progress memori loss cognit declin under mechan ad fulli understood present method detect ad earli stage recent studi indic mitochondria dysfunct relat ad pathogenesi alter mitochondria function found ad influenc amyloid tau patholog variat mitochondria dna mtdna lead chang energi metabol brain contribut ad mtdna reflect status mitochondria therefor play essenti role ad review summar chang mtdna mtdna mutat ad patient discuss possibl mtdna biomark earli diagnosi ad
|
D000544
|
T047;T048
|
36,292,673
|
bta mir regul calcium influx bovin leydig cell associ sperm motil microrna mirna play key role sperm regulatori factor involv fertil subsequ earli embryon develop bta mir specif high enrich mirna low motil sperm previous studi investig mechan bta mir share target gene bta mir predict use two mirna target databas targetscan mirwalk accord kyoto encyclopedia gene genom kegg calcium camp signal pathway enrich target gene dual luciferas assay indic bta mir target atpa mrna bind code sequenc region bovin leydig cell bta mir overexpress affect intracellular calcium concentr restrain atpa express moreov observ high calcium concentr high atpa protein level high motil sperm compar low motil sperm furthermor high linkag singl nucleotid polymorph snps pre bta mir sequenc identifi relat sperm trait genotyp tctc bta mir show high sperm motil densiti low deform rate holstein bull howev mutat pre mir signific affect matur bta mir express sperm cell model result demonstr bta mir might involv sperm motil regul target atpa calcium signal pathway bovin spermatozoa
|
D002118;D035683
|
T123;T196;T121;T114
|
36,292,672
|
rearrang mitochondri gene centiped arthropoda myriapoda phylogenet analysi due limit taxon sampl differ result avail data phylogenet relationship myriapoda remain contenti therefor tri reconstruct analyz phylogenet relationship within myriapoda examin mitochondri genom mitogenom studi typic circular mitogenom mecistocephalus marmoratus scolopendra subspinip sequenc sanger sequenc bp bp length respect control region typic mitochondri gene annot sequenc result show pcgs start atn codon end tar codon singl interest gene order marmoratus extens rearrang compar myriapoda thus propos simpl duplicationloss model explain extens rearrang gene marmoratus hope provid insight mitogenom rearrang event myriapoda addit mitogenom phylogenet analys show main myriapod group monophylet support combin pauropoda diplopoda form dignatha within chilopoda suggest scutigeromorpha sister group lithobiomorpha geophilomorpha scolopendromorpha also identifi close relationship lithobiomorpha geophilomorpha result also indic mitogenom use effect mechan understand phylogenet relationship within myriapoda
|
D001181
|
T204
|
36,292,671
|
bioinformat experiment analys reveal mapk potenti marker gastric cancer gastric cancer remain preval high lethal diseas worldwid mapk member ste play import role various patholog includ cancer howev role gastric cancer yet fulli elucid therefor studi aim determin tumor promot role mapk gastric cancer whether use new reliabl biomark predict prognosi gastric cancer purpos divid sampl high low express group accord express level mapk associ mapk express prognosi assess use kaplan meier surviv analysi furthermor immun infiltr analysi use estim conduct evalu tumor immun score sampl
|
D013274;D035683
|
T123;T191;T114
|
36,292,670
|
optim oxford nanopor technolog sequenc workflow detect amplicon real time use ont dart tool optim well test valid target genom sequenc base high throughput assay current avail readi routin biodefens biosurveil applic earlier address gap develop establish baselin comparison multiplex end point polymeras chain reaction pcr assay follow oxford nanopor technolog ont base amplicon sequenc real time pcr custom data process expand upon effort identifi optim ont librari prepar method integr novel softwar platform ont dart ont detect amplicon real time ont dart docker real time amplicon sequenc analysi workflow use reproduc process filter read data support action amplicon detect call base align metric within sampl statist templat control data analysi pipelin use compar four ont librari prepar protocol use r flongl fl flow cell two primer method test requir shortest prepar time h librari provid lower fidel data nativ barcod ligat method requir longer prepar time h respect result higher overal data qualiti averag data deriv r flow cell produc true posit call target organ twice fast lower throughput fl flow cell result suggest util r flowcel ont nativ barcod amplicon librari method combin ont dart platform analyt provid best sequenc base altern current pcr base biodetect method
|
D058608
|
T082
|
36,292,669
|
singl nucleotid polymorph rs affect human scd promot activ associ diabet mellitus combin preval type tdm type tdm diabet mellitus worldwid constant increas pathophysiolog diseas includ disturb lipid metabol acyl coa desaturas play central role synthes unsatur fatti acid therebi provid protect lipotox stearoyl coa desaturas scd isoform receiv littl scientif attent aim investig scd promot polymorph vitro silico case control studi scd promot region determin luciferas report system hepg hekt sk n fi cell prove cell type specif insensit differ fatti acid effect scd promot polymorph rs rs test transfect cell allel rs singl nucleotid polymorph snp signific reduc activ scd promot vitro modifi sever transcript factor bind site silico statist signific associ rs snp tdm tdm also found thus support medic relev variat complex molecular mechan develop metabol disord conclus minor allel rs polymorph might contribut develop diabet influenc scd promot activ
|
D003922;D003924
|
T047
|
36,292,668
|
molecular evolut inherit pattern sox gene famili among bovida sox gene evolutionarili conserv famili transcript factor play import role cellular differenti numer complex development process vertebr sox protein requir cell fate decis morphogenesi control self renew embryon adult stem cell sox gene famili well studi multipl speci includ human scanti research bovida studi conduct detail evolutionari analysi gene famili bovida includ physicochem properti biolog function pattern inherit perform genom wide catalogu procedur explor sox gene famili use multipl bioinformat tool analysi reveal signific inherit pattern includ conserv motif critic abil sox protein interact regulatori region target gene orchestr multipl development physiolog process import report import conserv motif efdqyleldqyl found sox e sox f group sox group analysi reveal motif sequenc account bind transactiv potenti sox protein degre protein protein interact show signific interact among sox gene relat gene implic embryon develop regul cell differenti conclud sox gene famili uniqu evolv bovida exhibit import motif drive sever development physiolog process
|
D019143;D016678
|
T028;T038
|
36,292,667
|
genom wide survey analysi microsatellit waterlili potenti polymorph marker develop waterlili nymphaeacea diploid dicotyledon ornament aquat plant complet draft genom blue petal waterlili nymphaea colorata made avail genbank date genom wide mine microsatellit simpl sequenc repeat ssrs waterlili still absent present studi investig characterist genom wide microsatellit n colorata develop polymorph ssr marker across tropic hardi waterlili total ssrs identifi n colorata chromosom averag densiti ssrs per mb largest number ssrs present chromosom n ssrs per mb dinucleotid common type rich repeat prevail n colorata genom ssr occurr frequenc decreas number motif repeat increas among protein code region ssrs trinucleotid account abund gene ontolog term signal transduct eg go go lipoic acid metabol ko overrepres go kegg enrich analysi respect addit primer pair identifi novel polymorph ssr marker employ distinguish among nine waterlili cultivar ny ny inform ssr loci studi contribut first detail character ssrs n colorata genom deliv novel polymorph marker use molecular breed strategi genet divers popul structur analysi waterlili
|
D030721;D008063
|
T121;T127;T002;T109
|
36,292,666
|
integr bioinformat analysi reveal novel mirna biomark associ preeclampsia preeclampsia lead caus perinat matern foetal mortal morbid studi aim identifi key microrna mirna preeclampsia uncov potenti function download mirna express profil gse plasma gse placenta dataset consist five patient pe five control n technic point view analys count per million cpm dataset highlight mirna common uniqu plasma uniqu placenta time perform express differenti analysi logfc fdr evalu biolog impact mirna approach allow us highlight mirna common plasma placenta within four upregul plasma furthermor analysi reveal five mirna express exclus plasma also upregul conclus depth bioinformat analysi conduct studi allow us one hand verifi target nine identifi mirna hand use new non invas biomark therapeut target develop personalis treatment
|
D011225;D035683
|
T123;T046;T114
|
36,292,665
|
mutat analysi thin basement membran nephropathi thin basement membran nephropathi tbmn character observ microhematuria thin glomerular basement membran kidney biopsi specimen main caus heterozyg mutat cola cola also caus late onset focal segment glomerulosclerosi fsgs autosom domin alport syndrom ada thirteen tbmn case analyz use sanger sequenc multiplex ligat depend probe amplif mlpa exom sequenc ten heterozyg variant detect cola cola nine patient via sanger sequenc three novel variant diagnost rate like pathogen pathogen american colleg medic genet genom guidelin patient eight singl nucleotid variant seven glycin substitut collagen domain one splice site singl nucleotid variant two delet variant one patient digen variant cola cola mlpa analys show negat result exom sequenc identifi three heterozyg variant causat gene fsgs four patient appar variant sanger sequenc sinc patient heterozyg mutat cola cola show wide spectrum diseas tbmn ada care follow necessari patient
|
D005923;D009394
|
T047
|
36,292,664
|
genet divers diverg time extant primit mayfli siphluriscus chinensi ulmer use mitochondri genom studi mitochondri mt genom siphluriscus chinensi ephemeroptera siphluriscida evalu specimen collect two site china niutou mountain zhejiang provinc chinensi nts leigong mountain guizhou provinc chinensi lgs success sequenc length mt genom chinensi nts chinensi lgs bp bp respect howev depth comparison two mt genom show signific differ specimen collect two site detail analysi genet distanc chinensi nts chinensi lgs undertaken achiev accur delimit chinensi genet distanc chinensi nts three speci within siphluriscida high valu two mt genom use reconstruct phylogenet relationship estim diverg time result demonstr robust differ chinensi nts chinensi lgs reveal kind cryptic speci exist maximum likelihood ml bayesian infer bi analys produc well support phylogenet tree show evolutionari relationship siphluriscida chinensi hq chinensi mf chinensi lgs chinensi nts recent common ancestor mrca four speci within siphluriscida began diversifi neogen million year ago mya highest posterior densiti hpd mya chinensi nts first diverg branch chinensi lgs short base mitochondri genom result show specimen collect leigong mountain guizhou provinc chinensi lgs belong chinensi specimen collect niutou mountain zhejiang provinc chinensi nts cryptic speci chinensi
|
D054629;D065133
|
T204;T028
|
36,292,663
|
identif character lt gt knox lt gt gene famili activ regul leaf develop lt gt trifolium repen lt gt leav primari critic feed herbivor direct determin yield qualiti legum forag lt gt trifolium repen lt gt lt gt repen lt gt indispens legum speci wide cultiv temper pastur due nutrit valu nitrogen fixat although leav lt gt repen lt gt typic trifoli unusu pattern adapt herbivor feed number leaflet lt gt repen lt gt affect product util lt gt knox lt gt gene famili encod transcript regul vital regul develop leav identif character lt gt trknox lt gt gene famili activ regul leaf develop lt gt repen lt gt studi total lt gt trknox lt gt gene identifi repen genom databas classifi three subgroup class class ii class base phylogenet analysi nineteen gene identifi four conserv domain except lt gt knox lt gt lt gt knox lt gt belong class vari express level trknox gene observ differ development stage complex leav lt gt knox lt gt observ upregul leaf complex repen research lt gt trknox lt gt gene could novel assist explor function cultiv high qualiti lt gt repen lt gt varieti
|
D029921
|
T002
|
36,292,662
|
character mad box gene famili akebia trifoliata evolutionari event angiosperm largest clade modern plant flower plant evolv wide varieti flower fruit mad box gene play key role regul plant morphogenesi basal eudicot evolutionarili import posit act evolutionari bridg basal angiosperm core eudicot akebia trifoliata import member basal eudicot group studi earli evolut angiosperm identifi character mad box gene famili whole genom level trifoliata mad box gene type type ii gene trifoliata genom type gene greater gene length coeffici variat smaller exon number type ii gene total experienc whole segment genom duplic purifi select transcriptom analysi suggest three eight gene involv whole fruit seed develop respect diversif phylogenet analysi type ii mad box gene angiosperm speci provid clue indic whole genom triplic event eudicot possibl experienc two step process result valuabl improv trifoliata fruit trait theoret elucid evolutionari process angiosperm especi eudicot
|
D019684
|
T002
|
36,292,661
|
ancient compon recent expans eurasian heartland insight revis phylogeni chromosom central asia past two decad studi chromosom singl nucleotid polymorph snps short tandem repeat strs shed light demograph histori central asia heartland eurasia howev complex pattern migrat admixtur complic popul genet studi central asia sequenc analyz chromosom male individu kazakh kyrgyz uzbek karakalpak hazara karluk tajik uyghur dungan turkmen popul high divers admixtur peripher area eurasia observ among patern gene pool popul general pattern larg attribut activ ancient peopl four period includ neolith farmer indo european turk mongol import detect consist expans mani minor lineag past thousand year may correspond direct format modern popul region newli discov sub lineag variant provid basi studi contribut minor lineag format modern popul central asia
|
D041322;D005828
|
T026;T090
|
36,292,660
|
associ genet variant comt oprm gene pain percept among patient undergo total hip knee arthroplasti primari osteoarthr year approxim million total hip replac perform worldwid common indic choos procedur rest pain pain activ well function limit influenc daili activ experiment pain high variabl individu part due genet aim studi investig possibl associ catechol methyltransferas comt opioid receptor oprm genotyp pain percept patient undergo total hip replac total knee replac take account aspect age sex diabet studi includ patient femal male median age year rang qualifi surgic treatment total hip replac knee arthroplasti due osteoarthr pain sensit measur perform use standard algomet genom dna extract buccal cell singl locus analysi conduct use general linear model studi group find statist signific genet associ variant comt oprm pain thresholdspain toler analysi subject pain percept use visual analog scale show relationship oprm rsa amp gt g variant comt rs rs rs rs
|
D019645;D010003
|
T061;T047
|
36,292,659
|
novel singl nucleotid polymorph wnt promot affect transcript respons fsh chicken follicl signal pathway wingless type mous mammari tumor virus integr site wnt play import role ovarian follicular develop previous studi wnt shown involv select develop chicken follicl upregul express follicl stimul hormon receptor fshr stimul prolifer follicular granulosa cell increas secret steroid hormon fsh also stimul express wnt explor molecular mechan fsh upregul wnt character cis element regul wnt transcript studi determin critic regulatori region affect chicken wnt transcript identifi singl nucleotid polymorph snp region final analyz associ snp chicken product trait result show regulatori region wnt strongest activ greatest respons fsh stimul identifi one snp site segment g amp gt c affect bind nfat nuclear factor activ cell respon fsh stimul g replac c site elimin nfat bind mrna level wnt small yellow follicl chicken genotyp gg signific higher two genotyp moreov locus found signific associ comb length hen individu genotyp cc longer comb collect data suggest snp g amp gt c involv regul wnt gene express respond fsh affect bind nfat associ chicken comb length current result provid refer reveal respons mechan wnt fsh
|
D002645;D011962
|
T116;T012;T192
|
36,292,658
|
identif genom region candid gene associ bodi weight bodi conform trait karachai goat object studi identifi snps candid gene relat bodi weight seven bodi conform trait age month russian aborigin karachai goat n conduct genom wide associ studi gwas use genotyp generat goat snp beadchip illumina inc usa identifi snps signific associ studi trait includ genom wide snps p amp lt suggest snps p amp lt distribut among goat autosom except autosom fifti six snps common two trait snp six trait snps five trait snps four trait snps three trait snps two trait snps associ singl trait structur annot within window mb mb causal snps reveal candid gene largest number candid gene identifi chr candid gene five trait gene identifi studi previous report associ growth relat trait differ livestock speci signific gene bodi weight cradd hmga msrb max hacl rab regul growth process bodi size fat deposit averag daili gain among hmga gene well known candid prenat earli postnat develop msrb gene propos candid gene affect growth perform apob ptprk bcar aoah asah gene associ wither height rump height bodi length involv various metabol process includ fatti acid metabol lipopolysaccharid catabol addit wdr zbtb adipoq sorc gene link chest width kcng associ rump height bodi length chest perimet identifi candid gene propos molecular marker growth trait select genet improv karachai goat
|
D055106;D006041
|
T063;T015
|
36,292,657
|
multidisciplinari progress obes research obes chronic diseas endang human health recent year phenomenon obes becom common becom global epidem obes close associ mani advers metabol chang diseas insulin resist type diabet mellitus coronari heart diseas nervous system diseas malign tumor caus huge burden countri medic financ countri world incid cancer caus obes increas year year diabet associ obes lead secondari neuropathi treat obes secondari diseas becom urgent problem patient doctor societi articl summar multidisciplinari research obes complic
|
D003924;D007333
|
T047;T046
|
36,292,656
|
sex bias express olfact relat gene antenna api cerana hymenoptera apida olfactori system essenti honeybe adapt complex ever chang environ maintain cohes eastern honeybe api cerana nativ asia long histori manag beekeep china studi analys antenn transcriptom cerana worker drone use illumina sequenc total differenti express gene deg fold chang amp gt identifi two cast upregul downregul drone compar worker identifi candid olfact relat gene includ odour bind protein obp chemosensori protein csps odour receptor or gustatori receptor grs ionotrop receptor ir sensori neuron membran protein snmps putat odour degrad enzym ode olfact relat gene worker bias express drone bias express gene high express worker antenna gene high express drone antenna fpkm amp gt use real time quantit pcr rt qpcr verifi reliabl differenti gene infer transcriptom compar express profil or acor acor acor acor acor acor worker drone or express signific higher level antenna tissu p amp lt clear variat express level or differ age worker drone relat express level acor acor acor acor acor reach high peak day old drone result contribut futur research olfact mechan cerana help better reveal odour recept variat differ biolog cast honeybe
|
D018035;D006927
|
T116;T204;T192
|
36,292,655
|
crazi biolog sinc end advent molecular biolog begin sequenc whole genom modern tool never ceas amaz us provid answer question nt even dare ask eleph fewer cancer human human big brain eukaryot cell recogn foreign dna sequenc molecular crossroad incompat function cell count fascin question made biolog recent year almost crazi
|
D016678;D008967
|
T091;T028
|
36,292,654
|
integr histolog genom analysi predict hepatocellular carcinoma prognosi use deep learn cancer prognosi analysi essenti interest clinic practic order explor prognost power comput histopatholog genom paper construct multi modal prognost model surviv predict collect patient diagnos hepatocellular carcinoma hcc cancer genom atlas tcga patient whole slide imag wsis mrna express file wsis process multi instanc deep learn model obtain patient level surviv risk score mrna express data process weight gene co express network analysi wgcna top hub gene modul extract risk factor inform two modal integr cox proport hazard model predict patient outcom overal surviv predict multi modal model concord index c index confid interv ci outperform base histopatholog risk score hub gene respect furthermor predict year year surviv area curv model achiev conclus paper provid effect workflow multi modal prognosi hcc integr histopatholog genom inform potenti assist clinic prognosi manag
|
D006528;D008113;D000077321
|
T191;T066
|
36,292,653
|
associ comt rs gene polymorph person dimens anxieti patient diagnosi stimul depend research hypodopaminerg hypothesi addict show hypodopaminerg activ male predict number drug use associ drug seek behavior variant allel may caus hypodopaminerg function result reduc densiti dopamin receptor decreas respons dopamin increas dopamin clearanc metabol reward system catechol methyltransferas comt involv metabol dopamin person trait may mediat genet predisposit substanc use disord addit various motiv associ reward seek regul negat emot also relat self control environ select
|
D019966;D003042
|
T121;T109;T131;T033;T048
|
36,292,652
|
mine candid gene relat heavi metal matur melon cucumi melo l peel pulp use wgcna content metal ion fruit insepar plant intak trace element health effect human bodi understand metal ion content fruit pericarp melon cucumi melo l candid gene respons control process analyz metal ion content distinct part melon fruit pericarp perform rna seq result show content metal ion melon fruit tissu signific higher pericarp base transcriptom express profil found fruit pericarp contain elev level deg go function annot includ cell surfac receptor signal signal transduct organ substanc metabol carbohydr deriv bind hormon mediat signal pathway kegg pathway includ pectat lyas pentos glucuron interconvers h transport atpas oxid phosphoryl plant hormon signal transduct mapk signal pathway also analyz express pattern gene transcript factor involv hormon biosynthesi signal transduct use weight gene co express network analysi wgcna co express network construct identifi specif modul signific correl content metal ion melon gene express modul measur connect qrt pcr identifi five candid melon gene loc loc loc loc loc associ metal ion content studi provid theoret basi understand molecular mechan heavi metal ion content melon fruit peel provid new genet resourc studi heavi metal ion content plant tissu
|
D028463;D019662;D014131;D019216
|
T121;T123;T168;T196;T002
|
36,292,651
|
identif phylogeni diverg structur express analysi aan zinc finger domain contain stress associ protein sap gene jatropha amp amp nbsp curca l jatropha small woodi perenni biofuel produc shrub stress associ protein sap novel stress regulatori zinc finger protein main associ toler various environment abiot stress jatropha present studi jcsap gene famili analyz comprehens jatropha curca jcsap gene identifi phylogenet analysi classifi jcsap gene four group base sequenc similar similar gene structur featur conserv andor domain respons motif moreov diverg analysi evalu evolutionari aspect jcsap gene predict time diverg mya furthermor divers rang cis element includ light respons element hormon respons element stress respons element detect promot region jcsap gene mirna target site predict regul jcsap gene via candid mirna mediat post transcript regulatori network addit express profil jcsap gene differ tissu stress treatment indic mani jcsap gene play function development role differ tissu exhibit signific differenti express stress treatment result collect laid foundat function diversif jcsap gene
|
D031286;D035683
|
T123;T002;T114
|
36,292,650
|
compar mitogenom analys new insight phylogeni thamnocephalida branchiopoda anostraca thamnocephalida famili anostraca wide distribut contin world except antarctica current consist six genera approxim recogn speci relationship among genera thamnocephalida monophyli thamnocephalida determin use morpholog characterist gene marker remain controversi order address relationship within thamnocephalida sequenc branchinella kugenumaensi mitogenom conduct compar analysi reveal diverg across mitogenom b kugenumaensi use newli obtain mitogenom togeth avail anostracan genom sequenc present complet phylogenom understand anostraca date observ high diverg across mitogenom b kugenumaensi meanwhil phylogenet analys base amino acid nucleotid protein code gene pcg provid signific support non monophylet thamnocephalida within anostraca asian branchinella close relat streptocephalida australian branchinella phylogenet relationship within anostraca recov follow branchinectida chirocephalida basal group anostraca halophil artemiida sister clade thamnocephalida streptocephalida bayesian infer bi maximum likelihood ml base analys produc ident topolog
|
D033202;D054629
|
T028;T204
|
36,292,649
|
alpelisib efficaci hormon receptor posit negat pikca mutant advanc breast cancer post everolimus treatment real world cohort analysi assess efficaci alpelisib endocrin treatment et combin post everolimus set thirteen women start alpelisib et standard dose advanc breast cancer abc undergo cdki everolimus treatment elig studi entri primari endpoint progress free surviv pfs secondari endpoint object respons rate orr clinic benefit rate cbr differ molecular profil patient previous receiv median four rang system treatment includ cdki everolimus median pfs alpelisib month rang four women orr three stabl diseas month cbr similar byleiv studi cohort c notabl cohort includ patient long cbr everolimus treatment median month rang howev respons alpelisib everolimus correl pearson r p pikca p arid gata esr mutat associ month cbr despit heavi pre treatment includ everolimus alpelisib clinic relev cohort even among patient esr mutat best treatment sequenc pikcamtor inhibitor warrant examin futur trial pikca mutant inpati lumin abc
|
D001943
|
T191
|
36,292,648
|
genom wide identif analysi mad box gene famili almond reveal express featur differ flower period mad box gene famili import famili transcript factor involv multipl process plant growth develop stress particular flower time floral organ develop almond best sell nut intern fruit trade account world dri fruit trade one main econom fruit tree kashgar xinjiang addit almond contain varieti nutrient protein dietari fiber supplement nutrient peopl also function nourish yin kidney improv eyesight strengthen brain appli various diseas howev report mad box gene famili almond prunus dulci studi total pdmad gene distribut across chromosom identifi genom almond wanfeng pdmad member divid five subgroup mikc member subgroup conserv motif type exon intron number number exon pdmad member rang number intron rang number exon intron differ subfamili member vari great result gene duplic analysi show pdmad member pair segment duplic pair tandem duplic explor relationship mad box gene member almond arabidopsi thaliana oryza sativa malus domestica prunus persica base colinear gene evolutionari select pressur result cis act element show pdmad member extens involv varieti process almond growth develop hormon regul stress respons addit express pattern pdmad member across six floral transcriptom sampl two almond cultivar wanfeng nonpareil signific express differ subsequ fluoresc quantit express level pdmad gene high similar transcriptom express pattern gene express level increas sampl differ flower stage indic two almond cultivar express differ pdmad gene flower process worth note differ flower time wanfeng nonpareil may caus differ express activ pdmad pdmad dormanc period result differ process vernal identifi total target gene genom base mikc dna bind site go kegg enrich result show target gene play import role protein function multipl pathway summari conduct bioinformat express pattern studi pdmad gene famili investig six flower sampl two almond cultivar earli flower wanfeng late flower nonpareil quantit express level identif find lay foundat futur depth studi mechan pdmad gene regul flower differ almond cultivar
|
D000068181;D017360
|
T168;T002
|
36,292,647
|
genotyp phenotyp review kabuki syndrom kabuki syndrom ks rare neuro development disord caus variant gene histon modif includ kmtd kdma review assess current understand ks origin name niikawa kuroki syndrom aim guid surveil medic care affect individu well identifi gap knowledg unmet patient need ovid medlin embas databas search identifi report relat genotyp system base phenotyp character ks total articl retriev includ review repres total individu ks genotyp phenotyp development behavior profil ks review continu clinic phenotyp spectrum associ ks notabl variabl affect individu emerg genotyp phenotyp correl observ clinic variabl may attribut differ genotyp andor unknown genet epigenet factor clinic manag symptom orient fragment lack establish clinic care standard addit research focus enhanc understand burden ill impact qualiti life adult phenotyp life expect develop standard care guidelin
|
D011788;D056466
|
T078;T126;T116
|
36,292,646
|
central role telomer dysfunct format uniqu transloc within sub telomer region result duplic partial trisomi telomer play major role maintain genom stabil integr putat involv telomer dysfunct format various type chromosom aberr area activ research report case six month old boy chromosom gain encompass qq region identifi snp array analysi size duplic mb contain gene omim duplic result partial trisomi region question clinic consequ includ bilater renal dysplasia delay develop heart defect moreov karyotyp determin r band chromosom paint well hybrid specif sub telomer probe reveal presenc unbalanc p q transloc uniqu breakpoint involv sub telomer region short arm chromosom karyotyp parent normal telomer integr circul lymphocyt child parent assess use autom high throughput method base fluoresc situ hybrid fish telomer centromer specif pna probe follow fish multicolor karyotyp short telomer well increas frequenc telomer loss format telomer doublet detect child cell interest similar telomer profil found circul lymphocyt father moreov assess clonal telomer aberr identifi chromosom particular high frequenc aberr find strong suggest telomer dysfunct play central role format specif unbalanc chromosom rearrang via chromosom end end fusion breakag fusion bridg cycl
|
D014314;D014178
|
T049;T019
|
36,292,645
|
singl cell rna seq identifi immun relat prognost model key signatur spp pancreat ductal adenocarcinoma reliabl biomark earli diagnosi prognosi evalu pancreat ductal adenocarcinoma pdac multipl scrna seq dataset pdac retriev onlin databas combin scrna seq result previous studi malign ductal cell identifi calcul copi number variat cnv score robust marker malign ductal cell pdac found five immun relat signatur includ spp linc snhg linc casc use develop risk score formula predict overal surviv pdac patient also construct easi use nomogram combin risk score n stage margin status express level spp relat prognosi immun regul found spp main express ductal cell macrophag pdac conclus construct promis prognost model base immun relat signatur pdac use scrna seq tcgapaad dataset
|
D021441;D010190
|
T191
|
36,292,644
|
use sequenc similar base cksnp featur graph neural network model identifi mirna diseas associ among mani machin learn model analyz relationship mirna diseas predict result optim establish differ machin learn model less attent paid featur inform contain mirna sequenc studi focus impact differ featur inform mirna sequenc relationship mirna diseas found graph neural network use mirna featur base k spacer nucleic acid pair composit cksnap featur adopt better graph neural network predict model mirna diseas relationship could built auc greater best model literatur base benchmark dataset optim model also use predict mirna relat lung tumor esophag tumor kidney tumor top mirna relat three diseas predict separ model consist descript wet experi valid databas dbdemc
|
D035683;D004938
|
T123;T191;T114
|
36,292,643
|
learn bias microbiom studi analyz data mock communiti known data shotgun metagenom studi subject bias caus observ relat abund taxa differ true valu model communiti analys relat abund taxa sampl known construct seem offer hope bias measur howev unclear whether bias measur mock communiti analysi measur sampl taxa spike known relat abund bias measur spike sampl bias would measur real eg biolog sampl consid question context rrna measur three set sampl commerci avail zymo cell model communiti zymo model communiti mix swedish snus smokeless tobacco product virtual bacteria free set commerci avail smokeless tobacco product set sampl subject four differ extract protocol goal analysi determin whether pattern bias observ set sampl ie learn bias commerci avail smokeless tobacco product studi zymo cell model communiti
|
D064307
|
T001;T032;T028
|
36,292,642
|
unravel tumour microenviron melanoma singl cell level challeng checkpoint immunotherapi melanoma known one immunogen tumour often characteris high mutat burden neoantigen load immun infiltr applic immunotherapi led impress improv clinic outcom advanc stage melanoma patient standard care immunotherapi leverag host immunolog influenc tumour cell entail complex interact among tumour stroma immun cell tumour microenvironment level howev cancer patient achiev long term durabl respons immunotherapi signific proport patient develop resist still die diseas owe multi facet problem tumour microenvironment heterogen identifi key factor under tumour progress immunotherapi resist pose great challeng review outlin main challeng current cancer immunotherapi research pose tumour heterogen microenviron complex includ genom transcriptom variabl select outgrowth tumour subpopul spatial tempor tumour heterogen dynam state host immun microenviron orchestr also highlight opportun dissect tumour heterogen use singl cell sequenc spatial platform integr analys larg scale dataset enabl depth explor biolog question facilit clinic applic translat research
|
D059016;D008545
|
T070;T191
|
36,292,641
|
conceal substrat brugada syndrom isol channelopathi associ cardiomyopathi brugada syndrom brs inherit autosom domin genet disord respons sudden cardiac death malign ventricular arrhythmia term channelopathi nowaday use classifi brs pure electr diseas main occur secondarili loss function mutat subunit cardiac sodium channel protein nav set arrhythm manifest diseas report absenc appar structur heart diseas cardiomyopathi last year howev consist amount evid grown support myocardi structur function abnorm patient brs detail abnorm ventricular dimens either systol diastol dysfunct region wall motion abnorm myocardi fibrosi activ inflammatori foci frequent describ point altern mechan arrhythmogenesi challeng definit channelopathi present review aim depict status art conceal arrhythmogen substrat brs often result advanc multimod diagnost workup foster futur preclin clinic research support cardiomyopath natur diseas
|
D053840;D009202
|
T033;T047
|
36,292,640
|
integr studi differenti express fox gene famili cancer respons chemotherapi drug forkhead box fox transcript factor one largest gene famili human play key role cancer although studi suggest sever fox transcript factor signific impact cancer function fox gene cancer remain elus studi express fox gene kind cancer diseas includ mani subtyp cancer respons chemic substanc obtain gene express atlas databas european bioinformat institut base high degre overlap foxo famili member differenti express various cancer particular respons chemotherapeut drug data disclos fox gene play import role develop progress cancer import predict role one sever combinatori fox gene diagnosi prognost assess specif cancer evalu potenti certain anticanc drug therapi type cancer integr pattern fox gene express anticanc drug sensit
|
D009369
|
T191
|
36,292,639
|
pre administr plx r cell protect mice radiat induc hematopoiet failur lethal acut radiat syndrom ar syndrom involv damag multipl organ caus exposur high dose ioniz radiat short period time even low dose radiat damag radiosensit hematopoiet system caus h ar placenta expand plx r expand placenta deriv stromal cell product design treatment hematolog disord cell shown vitro secret hematopoiet protein stimul coloni format induc bone marrow migrat previous studi mice show plx r cell respond radiat induc hematopoiet failur transient secret hematopoiesi relat protein enhanc reconstitut hematopoiet system assess potenti effect prophylact plx r treatment h ar plx r cell administ intramuscular cbl mice day ld total bodi irradi plx r treatment signific increas surviv irradi p amp lt addit peripher blood bone marrow bm cellular monitor sever time point day plx r treatment signific increas number coloni form hematopoiet progenitor femor bm signific rais peripher blood cellular plx r administr attenu biomark bone marrow aplasia epo fltl sepsi saa system inflamm sp selectin e selectin attenu radiat induc inflammatori cytokineschemokin growth factor includ g csf mip mip b il il mcp addit plx r also amelior radiat induc upregul pakt taken togeth prophylact plx r administr may serv protect measur mitig bone marrow failur symptom system inflamm h ar model
|
D054508;D006413
|
T022;T037
|
36,292,638
|
homozyg invers chromosom involv sgcg detect short read whole genom sequenc patient suffer limb girdl muscular dystrophi new techniqu molecular genet diagnost allow accur diagnosi larg proport patient muscular diseas nevertheless mani patient remain unsolv although clinic histori andor muscl biopsi give clear indic involv gene mani case strong suspicion caus must lie unexplor gene area deep intron non code region order find chang next generat sequenc ngs method constant evolv make possibl sequenc entir genom reveal previous uninvestig region present young woman strong suspect far genet unsolv sarcoglycanopathi base clinic histori muscl biopsi use short read whole genom sequenc wgs homozyg invers chromosom involv sgcg linc detect breakpoint intron sgcg led absenc sarcoglycan result manifest autosom recess limb girdl muscular dystrophi lgmdr young woman
|
D049031;D049288
|
T026;T123;T047;T116
|
36,292,637
|
effect glucan synthas gene ffgs overexpress stress respons fruit bodi develop flammulina filiformi glucan synthas key enzym glucan synthesi play vital role cell wall cross link fungi howev role glucan synthas gene develop fruit bodi stress respons macrofungi larg unknown studi four overexpress transform glucan synthas gene ffgs success obtain gene function studi flammulina filiformi overexpress ffgs increas width mycelium cell improv toler abil mechan injuri oxid stress moreov ffgs gene express fluctuat regul recoveri process mycelium injuri show negat correl ho concentr fruit bodi phenotyp test show mycelia recoveri abil scratch improv ffgs gene overexpress howev primordia format stipe elong abil signific inhibit find indic ffgs involv regul myceli cell morpholog myceli stress respons fruit bodi develop f filiformi
|
D048690;D005638
|
T168;T004;T002
|
36,292,636
|
biomark monitor renal damag due fabri diseas patient treat migalastat review nephrologist nephropathi major fabri diseas complic kidney biopsi reveal glomerulosclerosi even pediatr patient main manifest fabri nephropathi includ reduc glomerular filtrat rate proteinuria oral pharmacolog chaperon approv treat fabri patient amen mutat fabri diseas rare disord frequent caus kidney damag ii new therapeut current avail necessari review wich biomark use nephropathi follow among fabri amen patient receiv migalastat literatur search conduct medlin embas scopus cochran googl academ prospect studi renal biomark depend variabl criterion least month follow includ final record relev inform ad hoc databas summar main result date main use biomark nephropathi monitor among fabri amen patient receiv migalastat glomerular filtrat rate estim equat includ serum creatinin
|
D000795;D007674
|
T047
|
36,292,635
|
splice variant myh gene causat famili isol left ventricular noncompact cardiomyopathi variant myh gene associ number primari cardiac condit includ left ventricular noncompact cardiomyopathi lvnc case myh relat diseas associ variant type missens substitut frame indel thus truncat variant myh myhtv associ mechan haploinsuffici usual consid pathogen disord howev recent larg scale studi demonstr evid signific myhtv lvnc gave rise assumpt haploinsuffici may causal mechan lvnc articl present famili isol lvnc heterozyg splice variant myh gene analyz possibl consequ variant conclud variant predict truncat realli act haploinsuffici studi highlight import precis assess myh splice variant particip develop lvnc
|
D056830;D009202
|
T047
|
36,292,634
|
compar analysi evolut flower gene sugar pathway brassicacea sugar play import role regul flower plant howev studi gene relat flower regul sugar pathway brassicacea plant scarc studi perform comprehens compar genom analysi flower gene sugar pathway seven member brassicacea includ arabidopsi thaliana arabidopsi lyrata astelia pumila camelina sativa brassica napus brassica oleracea brassica rapa identifi flower gene sugar pathway plant categor nine group protein domain analysi demonstr idd show strike structur variat differ brassicacea speci select pressur analysi reveal sugar pathway gene relat flower subject strong purifi select collinear analysi show identifi flower gene expand vari degre sus absent genom astelia pumila camelina sativa brassica napus brassica oleracea brassica rapa tissu specif express apadg indic function differenti sum genom wide identif reveal expans contract divers flower gene sugar pathway brassicacea evolut studi lay foundat studi evolutionari characterist potenti biolog function flower gene sugar pathway brassicacea
|
D001937;D017360;D029741;D029688
|
T168;T002
|
36,292,633
|
rare heterozyg pcsk variant human obes contribut pyh variant literatur review recent report heterozyg pcsk variant caus partial pc defici result signific increas risk obes effect almost exclus generat rare pyh rs grchp nm ct amp gt c variant affect pc matur enzymat capac identifi individu heterozyg pyh variant belgian origin perform follow studi popul children adolesc obes lean individu identifi three obes four lean pyh carrier p sanger sequenc high result melt curv analysi indic associ obes haplotyp analysi perform pyh carrier non carrier obes lean two pyh famili show ident haplotyp heterozyg carrier p amp lt likewis state art literatur concern role rare heterozyg pcsk variant impli rare associ monogen obes first degre carrier relat patient pc defici most report obes furthermor recent meta analys indic robust associ scarc disrupt heterozyg pcsk variant obes clinic signific less sometim lack nonsynonym variant
|
D009765;D045664
|
T047;T126;T116
|
36,292,632
|
combin gene mutat express candid gene improv diagnosi escobar syndrom escobar syndrom rare autosom recess disord affect musculoskelet system skin mutat chrng tpm gene associ patholog studi conduct clinic genet investig five patient also explor via silico gene express analysi phenotyp variabl detail identifi patient novel composit heterozyg variant chrng gene two recurr mutat chrng tpm rest patient clinic particular report list modifi gene patient suffer myopathi moreov identifi decreas express igf could relat short statur escobar patient increas express polg specif patient tpm mutat studi identifi genet spectrum escobar syndrom tunisian popul allow set genet counsel prenat diagnosi famili risk addit highlight relev biomark could differenti patient differ genet defect
|
D007334;D011978
|
T123;T116;T192
|
36,292,631
|
de novo assembl transcriptom analysi reveal preliminari molecular mechan primordium format pleurotus tuoliensi primordium format extrem import yield pleurotus tuoliensi howev molecular mechan under primordium format larg unknown studi investig transcript properti primordium format p tuoliensi compar transcriptom clean read assembl transcript unigen total differenti express gene identifi deg alter stage go kegg enrich analysi show deg involv oxidoreductas activ glycolysisgluconeogenesi mapk signal pathway ribosom result support understand transcript chang molecular process under primordium format differenti p tuoliensi
|
D020076
|
T004
|
36,292,630
|
identif cdk cdknd new prame target gene c like embryon stem cell embryon stem cell esc present characterist pluripot heterogen correspond specif metast recent demonstr retino acid ra induc increas specif c like metast mark target gene specif two cell embryo stage preimplant prame preferenti express antigen melanoma one princip actor pluripot stage specif role ra respons addit prame overexpress varieti cancer molecular function poor understood investig prame downstream target use chromatin immunoprecipit sequenc chip seq assay ra enrich c like metast identifi two specif target gene cdk cdknd bound prame two target involv cancer dedifferenti pluripot valid ra resist esc observ first time prame control cdk cdknd gene esc ra treatment shed light regulatori network behind establish nave pluripot
|
D000951;D008545
|
T129;T191;T116
|
36,292,629
|
classif protein sequenc novel align free method bacteri virus famili classif protein sequenc provid valuabl insight bioinformat exist method base sequenc align algorithm becom time consum size databas increas therefor need develop improv method effect classifi protein sequenc paper propos novel accumul natur vector method cluster protein sequenc lower time cost without reduc accuraci method project protein sequenc point dimension space accord amino acid distribut thus biolog distanc two protein easili measur euclidean distanc correspond point dimension space convex hull analysi classif perform robust virus bacteria dataset effect verifi method
|
D000596;D001419
|
T123;T121;T116;T007
|
36,292,628
|
exom sequenc identifi biallel galn variant paspasn caus mucopolysaccharidosi type iva pakistani consanguin famili mucopolysaccharidos mps type iva lysosom storag diseas main affect skelet system caus defici enzym n acetylgalactosamin sulfatas galn condit mistaken diagnos primari skelet dysplasia spondylo epiphys dysplasia share mani similar phenotyp featur utilis whole exom sequenc make diagnosi mps iva resourc poor countri report first time identif biallel galn missens variant cg amp gt paspasn pakistani popul highlight potenti contribut academ institut make rare diseas diagnosi absenc develop clinic genet servic
|
D009085;D002811
|
T047;T126;T116
|
36,292,627
|
map retrotransposon line sequenc two cebida speci homo sapien genom short review primat work focus distribut line long interspers nuclear element primat role evolut constitu architectur primat genom pinpoint line repeat distribut role among primat line probe map onto chromosom homo sapien hominida catarrhini sapajus apella cebus capucinus cebida platyrrhini use fluoresc situ hybridis fish choic platyrrhin speci due fact taxa characteris high level rearrang reason could use model studi line chromosom evolut line accumul found two cebida centromer almost acrocentr chromosom bi arm chromosom line pattern similar two speci chromosom due intrachromosom rearrang agreement previous hypothesis g band line interstiti accumul found human x chromosom chromosom signal also centromer posit agreement recent complet molecular sequenc analysi human chromosom acrocentr one thus hypothesi regard link line centromer well link rearrang discuss inde data analysi lead us support link line inter intrachromosom rearrang well link line structur function centromer primat
|
D002427
|
T015
|
36,292,626
|
develop genom resourc mexican bursera section bullockia burseracea genom assembl annot marker discoveri three copal speci bursera compris tropic shrub tree speci center speci diversif mexico genom resourc develop genus scarc limit studi gene flow local adapt hybrid dynam studi base million illumina pair end read per speci perform de novo genom assembl annot three bursera speci bullockia section bursera bipinnata bursera cuneata bursera palmeri total length genom assembl mb b cuneata b palmeri b bipinnata respect assembl b palmeri retriev complet singl copi busco relat b cuneata b bipinnata ab initio gene predict recogn protein code gene genom featur simpl sequenc repeat ssrs also detect use de novo genom assembl refer identifi singl nucleotid polymorph snps set bursera individu moreov map filter read bursera speci chloroplast genom five burseracea speci obtain consensus sequenc rang kb length work contribut generat genom resourc import understudi genus tropic dri forest speci
|
D031233;D029403
|
T002
|
36,292,625
|
rna seq reveal protect mechan mongolian medicin molor dabo acut indomethacin induc gastric ulcer rat studi aim appli transcriptom determin molor dabo md protect healthi rat indomethacin ind induc gastric ulcer identifi mechan behind protect effect rat pretreat md gkg per day day induc gastric ulcer oral administr indomethacin mgkg unulcer untreat healthi rat use control effect treatment assess base ulcer index histolog patholog examin indic inflamm determin enzym link immunosorb assay transcriptom analysi perform identifi potenti pharmacolog mechan eventu identifi potenti target gene latter valid quantit revers transcript polymeras chain reaction qrt pcr pretreat md gastric ulcer along histopatholog featur reduc md signific p amp lt increas superoxid dismutas sod level ulcer reduc pepsin tnf il level rna seq analysi identifi number target gene md could potenti act mani gene involv pathway link anti inflammatori antioxid respons protect mechan gastric mucosa qrt pcr show alter express select gene srm ryr eno prkag eefa consist transcriptom result md exert protect effect ind induc gastric ulcer reduc inflammatori cytokin pepsin increas express sod level downregul srm ryr eno prkag eefa gene involv regul arginin prolin metabol calcium signal pathway hif signal pathway oxytocin signal pathway legionellosi possibl involv md mediat protect gastric ulcer
|
D013276
|
T047
|
36,292,624
|
ilf express earli sign oxid stress induc cytotoxicityapoptosi interleukin f ilf found involv various inflammatori patholog recent becom target therapeut purpos contrast ilf secret immun cell focus studi describ trigger ilf releas non immun cell particular focus ilf induc fibrosi ilf induct examin human lung epitheli bea b myeloid cell line well peripher blood mononuclear cell vitro exposur aqueous cigarett smoke extract cse inorgan mercuri cadmium apoptosi induc brefeldin fibrosi examin vitro evalu transit human primari dermal fibroblast myofibroblast observ stressor abl induc ilf gene express regardless cell type interest induct associ cytotoxicapoptot sign inhibit oxid stress n acetylcystein abrog cse induc cytotox ilf induc effect induct ilf accompani ilf protein express transit fibroblast myofibroblast influenc either recombin ilf supernat cse expos bea b addit ilf secret special activ immun cell underscor cell type independ induct ilf mechan inhibit oxid stress induc cytotox howev ilf involv dermal fibrosi condit use studi
|
D000111;D008628
|
T121;T116;T109;T131;T196
|
36,292,623
|
combin serum plasma biomark could improv predict perform alzheim diseas alzheim diseas ad predict either serum plasma biomark combin may increas predict power due high complex machin learn may also incur overfit problem paper investig whether combin serum plasma biomark featur select could improv predict perform ad patient normal control ncs enrol serum test patient ncs enrol plasma test among ad ncs serum plasma sampl common time repeat fold cross valid model featur select method use overcom overfit problem serum plasma biomark combin first test see simpli ad serum plasma biomark improv predict perform also caus overfit employ featur select algorithm develop overcom overfit problem last test predict perform time repeat fold cross valid model train test set found combin biomark improv ad predict also caus overfit featur select base combin serum plasma biomark solv problem produc even higher predict perform either serum plasma biomark combin featur select serum plasma biomark may critic implic understand pathophysiolog ad develop prevent treatment
|
D000544
|
T047;T048
|
36,292,622
|
transcriptom analysi reveal hormon pathway bzip gene respons decapit sunflow decapit essenti agricultur practic typic method analyz shoot branch howev unclear exact decapit control branch studi decapit sunflow plant led develop later bud accompani decreas indol acet acid iaa abscis acid aba level increas cytokinin ck level addit member habzip famili discov categor group use phylogenet conserv domain analysi intronexon structur motif composit habzip member also investig base tissu specif express express analysi follow decapit deriv transcriptom sever habzip member may involv control decapit induc bud outgrowth therefor hypothes dynam variat hormon level conjunct particular habzip gene led develop axillari bud sunflow follow decapit
|
D049248;D006368
|
T002;T037
|
36,292,621
|
anoctamin ano muscl disord narrat review anoctaminopathi refer group hereditari skelet muscl bone disord due mutat anoctamin ano encod gene ano ano amino acid protein anoctamin famili function predomin phospholipid scrambl play key role sarcolemm repair process monoallel mutat ano give rise autosom domin skelet dysplast syndrom gnathodiaphys dysplasia gdd biallel mutat underli continuum four autosom recess muscl phenotyp limb girdl muscular dystrophi type r lgmdr miyoshi distal myopathi type mmd metabol myopathi like pseudometabol phenotyp asymptomat hyperckemia ano muscl disord rare preval relat high northern european popul founder mutat cdupa weak general asymmetr begin proxim muscl lgmdr distal muscl mmd patient pseudometabol asymptomat hyperckemia phenotyp weak convers lgmdr mmd phenotyp may occur diseas progress clear genotyp phenotyp correl muscl biopsi display broad spectrum patholog rang normal sever dystroph chang intramuscular interstiti amyloid deposit observ approxim half patient symptomat support strategi remain mainstay treatment recent develop anim model ano muscl diseas could help achiev better understand under pathomechan provid invalu resourc therapeut discoveri
|
D049288;D009135
|
T047
|
36,292,620
|
associ aldh rs polymorph athlet perform japanes power strength athlet rs polymorph associ enzymat activ aldehyd dehydrogenas aldh weaken allel east asian recent report associ polymorph athlet status athlet cohort muscl strength non athlet cohort therefor hypothes associ aldh rs polymorph perform powerstrength athlet aim clarifi relationship aldh rs polymorph perform powerstrength athlet particip compris powerstrength athlet men women healthi control men women investig powerstrength athlet divid classic powerlift n weightlift n differ genotyp allel frequenc aldh rs polymorph associ perform aldh rs genotyp observ weightlift howev relat valu per bodi weight total record lower powerlift ga aa genotyp gg genotyp vs p partial result collect indic role aldh rs polymorph strength perform powerlift
|
D020641;D054874
|
T055;T086
|
36,292,619
|
epigenet epitranscriptom gene regul plasmodium falciparum use malaria malaria caus plasmodium parasit still one biggest global health challeng p falciparum deadliest speci human review discuss parasit develop adapt complex heterogen environ two host thank vari chromatin associ epigenet mechan first one small famili transcript factor apiap protein function master regul spatio tempor pattern gene express parasit life cycl addit chromatin plastic determin variabl parasit cell phenotyp link parasit growth virul transmiss enabl parasit adapt within host condit recent year epitranscriptom emerg new regulatori layer gene express present evid varieti trna mrna modif character plasmodium spp dynam chang abund parasit develop cell fate end outlin new biolog system like mosquito model deciph unknown epigenet mechan vivo novel methodolog studi function rna modif need discov achill heel parasit new knowledg futur strategi manipul epigenet epitranscriptom machineri parasit potenti provid new weapon malaria
|
D016778;D008288;D010961
|
T047;T204
|
36,292,618
|
mycobacterium tuberculosi genotyp drug suscept test result timor lest pilot studi tuberculosi tb preval major public health problem timor lest govern timor lest prioritis surveil tb drug suscept test dst understand burden tb tb drug resist countri moreov littl known origin mycobacterium tuberculosi mtb timor lest studi report mtb dst sequenc timor lest pilot studi carri conveni sampl tb isol mucopurul sputum collect presumpt tb patient capit dili juli decemb test phenotyp genotyp evid drug resist standard mtb cultur perform timor lest nation health laboratori nhl mtb isol sent victorian infecti diseas refer laboratori vidrl australia dst sequenc overal mtb isol detect nhl isol recov sub cultur vidrl isol suscept rifampicin isoniazid pyrazinamid ethambutol genotyp marker resist identifi sequenc lineag common result studi provid small snapshot mtb divers resist sampl region high tb incid futur invest whole genom sequenc capac timor lest make possibl undertak repres analys may use evalu transmiss dynam epidemiolog genotyp marker resist
|
D009169
|
T007
|
36,292,617
|
integr system biolog analysi transcriptom respons drought stress soybean glycin max l drought major abiot stressor caus yield loss limit grow area crop soybean import legum crop sensit water deficit condit suffer heavi yield loss drought stress improv drought toler soybean cultivar breed necessari understand mechan drought toler soybean studi appli sever transcriptom dataset obtain soybean plant drought stress comparison grown normal condit identifi novel drought respons gene under molecular mechan found signific updownregul differenti express gene deg core modul use gene co express analysi predict biolog role drought toler gene ontolog kegg analys reveal key biolog process metabol pathway involv drought toler photosynthesi glyceraldehyd phosphat dehydrogenas cytokinin dehydrogenas activ regul system acquir resist genom wide analysi plant cis act regulatori element cres transcript factor tfs perform identifi deg promot soybean furthermor ppi network analysi reveal signific hub gene main transcript factor regul express drought respons gene modul among four modul associ respons drought stress result indic glymag glymag glymag glymag glymag high degre interconnect thus could consid potenti candid improv drought toler soybean taken togeth find could lead better understand mechan under drought respons soybean may use engin drought toler plant
|
D055864;D007887
|
T070;T002
|
36,292,616
|
novel strategi construct integr linkag map f hybrid popul populus deltoid populus simonii genet linkag map tradit f popul inbr line estim frequenc recombin event parent provid full genet inform genet genom studi howev outbr forest tree almost imposs generat f popul high heterozygos long generat time propos novel strategi construct integr genet linkag map contain parent recombin inform restrict site associ dna sequenc radseq data f hybrid popul populus deltoid populus simonii select larg number specif rad tag construct linkag map contain two snps one heterozyg femal parent heterozyg male consequ integr map contain total rad tag linkag group total length cm averag genet distanc cm meanwhil two parent specif linkag map also construct snps heterozyg one parent homozyg found integr linkag map consensus genom sequenc p simonii p deltoid addit likelihood marker order linkag group integr map greater parent map integr linkag map accur parent specif linkag map construct f hybrid popul provid power genet resourc identifi quantit trait loci qtls domin effect assembl genom sequenc perform compar genom relat populus speci import novel strategi use outbr speci build integr linkag map
|
D032107
|
T002
|
36,292,615
|
meta analysi snps determin litter trait pig near snps associ pig litter size trait report base genom wide associ studi gwass aim studi gather integr previous report associ snps five litter trait total number born tnb number born aliv nba number stillborn sb litter birth weight lwt corpus luteum number cln order evalu common genet background perform meta analysi gwass total number born tnb record anim five pig popul studi gene largest number associ evalu litter trait gabrg rbp prkd stxbp gene associ evalu litter trait report one popul one trait base evalu interest candid gene prkd associ sb tnb trait base go term analysi prkd shown involv angiogenesi well result two new genom region previous report found associ tnb trait one snp locat sus scrofa chromosom ssc intron famc gene second snp locat ssc within intron agmo gene function analysi reveal strong candid causal gene under qtl ssc third best hit promis candid gene litter size found within sostdc gene associ lower male fertil rat show litter trait studi across pig popul genom region common base candid gene comparison prkd could interest candid gene wider associ fertil identifi new genom region ssc ssc associ tnb function analysi indic promis gene sostdc confirm affect male fertil mammal import find litter trait default link femal rather male
|
D055106;D020641
|
T063;T086
|
36,292,614
|
impact methionin synthas reductas polymorph chronic myeloid leukemia patient introduct metabol methionin folat play vital function cellular methyl reaction dna synthesi epigenet processhowev polymorph methionin receiv much attent recent medic genet research object ascertain whether common polymorph mtrr methionin synthas reductas ag gene could play role affect suscept chronic myeloid leukemia cml sudanes individu method case control studi extract analyz dna cml patient healthi control subject pcr rflp method result found signific differ age orgend patient group control mtrr ag genotyp distribut base hardi weinberg equilibrium p amp gt variat mtrr ag less signific frequent case cml control ci p amp lt addit ag gg genotyp g allel reduc cml risk odd ratio ci p ci p ci p ci respect p conclus data demonstr heterozyg homozyg mutant genotyp mtrr polymorph associ decreas risk develop cml sudanes popul
|
D020022;D015464
|
T032;T191
|
36,292,613
|
target anti mitochondri therapi futur oncolog like live organ cancer cell requir energi surviv interact environ mitochondria main organell energi product cellular metabol recent investig demonstr cancer cell hijack mitochondria immun cell behavior shed light pivot piec cancer puzzl depend normal cell articl illustr benefit new function mitochondria cancer cell urg hijack mitochondria describ function mitochondria help cancer cell surviv harsh tumor microenviron immun evas progress treatment resist recent evid put forward pivot role mitochondria metabol cancer stem cell cscs tumor compon respons cancer recurr metastasi theori highlight mitochondria cancer biolog explain target mitochondria may improv oncolog outcom
|
D008928;D009369
|
T026;T191;T043
|
36,292,612
|
co treatment erythroid cell thalassemia patient crispr cas base globin gene edit induct fetal hemoglobin gene edit ge effici strategi correct genet mutat monogen hereditari diseas includ thalassemia elsewher report crispr cas base gene edit employ effici correct thalassemia mutat hand robust evid demonstr increas product fetal hemoglobin hbf benefici patient thalassemia aim studi verifi whether de novo product adult hemoglobin hba use crispr cas gene edit combin hbf induct protocol gene edit globin mutat obtain use crispr cas base experiment strategi correct gene sequenc transcript correct gene analyz allel specif droplet digit pcr rt qpcr respect relat content hba hbf studi high perform liquid chromatographi hplc western blot hbf induct repurpos drug rapamycin use data obtain conclus demonstr maxim product hba hbf obtain ge correct rapamycin induc erythroid progenitor isol thalassemia patient conclus ge hbf induct might use combin order achiev de novo product hba togeth increas induc hbf
|
D017086;D013789
|
T047
|
36,292,611
|
gene panel sequenc identifi novel ryr pserpro variant candid malign hyperthermia multi minicor myopathi malign hyperthermia mh rare autosom domin pharmacogenet disord skelet muscl calcium regul trigger sevofluran suscept individu report korean mh multi minicor myopathi function support ryr mediat intracellular ca releas test b lymphocyt year old boy admit evalu progress torticolli accompani cervicothorac scoliosi preoper drape patient releas sternocleidomastoid muscl general anesthesia wrist ankl observ sever flexion contractur bodi temperatur c treat mh patient administ bolus dantrolen intraven mgkg sodium bicarbon minut muscl rigid tachycardia etco resolv next generat panel sequenc hereditari myopathi identifi novel ryr heterozyg missens variant nm ct amp gt c pserpro map mh domain protein hot spot mh mutat ex vivo ryr mediat intracellular ca releas test b lymphocyt show hypersensit ca respons isofluran caffein result abnorm ca releas proband famili member find expand clinic patholog spectra inform associ mh multi minicor myopathi
|
D008305;D007530
|
T121;T037;T109
|
36,292,610
|
prognost clinicopatholog function key cuproptosi regul fdx clear cell renal cell carcinoma clear cell renal cell carcinoma ccrcc common histolog subtyp renal cancer cuproptosi suggest novel therapi target cancer treatment howev function cuproptosi key regul fdx ccrcc remain unclear studi adequ explor prognost factor clinicopatholog characterist function fdx ccrcc found express fdx signific downregul ccrcc sampl patient higher fdx express signific better prognosi includ overal surviv os hazard ratio hr confid interv ci p amp lt diseas specif surviv dss hr ci p amp lt progress free surviv pfs hr ci p amp lt fdx clinic predictor stratifi patient high low risk poor surviv independ convent clinic featur area roc curv auc predict year os dss pfs nomogram model base fdx greater predict power individu prognost paramet fdx main particip oxid relat process mitochondri respir relat process associ immun infiltr level conclus cuproptosi key regul fdx could serv potenti novel prognost biomark ccrcc patient
|
D002292;D007680
|
T191
|
36,292,609
|
evolutionari comparison complet chloroplast genom convallaria speci phylogenet studi asparagacea genus convallaria asparagacea compris three herbac perenni speci wide distribut understori temper decidu forest northern hemispher although convallaria speci high medicin horticultur valu studi relat phylogenet analysi genus present studi assembl report five complet chloroplast cp sequenc three convallaria speci two c keiskei miq two c majali l one c montana raf use illumina pair end sequenc data cp genom high similar overal size bp consist pair invert repeat ir region bp separ larg singl copi lsc bp small singl copi ssc region bp cp genom contain uniqu gene includ protein code gene transfer rna gene ribosom rna gene gene content gene order content irsc boundari structur near ident among convallaria cp genom howev length vari due contractionexpans irlsc border simpl sequenc repeat ssr analys indic richest ssrs mononucleotid three high variabl region peta psbj psbi trns ccsa ndhd identifi valuabl molecular marker phylogenet analysi famili asparagacea use cp genom sequenc support monophyli convallaria form sister clade genus rohdea studi provid robust phylogeni asparagacea famili complet cp genom sequenc contribut studi molecular identif genet divers phylogeni convallaria
|
D054628;D031405;D000070357
|
T002;T028
|
36,292,608
|
ddt resist anophel pharoensi northern cameroon associ high cuticular hydrocarbon product despit contribut secondari vector malaria transmiss still enough inform suscept status insecticid present studi assess resist profil anophel pharoensi ddt tube test use screen mosquito popul collect far north region cameroon suscept ddt high ddt resist pharoensi popul maga simatou yangah mortal rate rang record direct sequenc sanger vgsc gene undertaken search kdr lfs mutat howev kdr allel detect resist sampl look cuticl alter chc identif quantit undertaken use gc ms gc fid high product cuticular hydrocarbon record popul yangah simatou ng chcsmg dri weight respect present find first ever describ develop cuticl resist pharoensi data suggest need expand surveil activ vector speci
|
D000852;D007306;D011722
|
T131;T204;T109
|
36,292,607
|
long read transcriptom equin bronchoalveolar cell use pacif bioscienc long read isoform sequenc generat full length transcript sequenc equin bronchoalveolar lavag fluid balf cell dataset consist hifi read compris mb polish sequenc inform result equin balf transcriptom consist full length transcript isoform origin uniqu gene gene consist previous annot gene novel gene identifi novel transcript addit previous known transcript includ transcript absent exist genom annot transcript map putat novel unannot gene fusion transcript incorpor exon multipl gene provid transcript level data equin balf cell resourc scientif communiti
|
D059467;D016678
|
T081;T028;T086
|
36,292,606
|
compar cross platform analysi identifi potenti biomark gene evalu teratozoospermia azoospermia male infertil global public health concern teratozoospermia qualit anomali spermatozoa morpholog contribut signific male infertil wherea azoospermia complet absenc spermatozoa ejacul thus serious need unveil common origin andor connect diseas studi aim identifi common potenti biomark gene two diseas via silico approach use meta analysi microarray data studi differenti express analysi gene perform four public avail rna microarray dataset two teratozoospermia gse gse azoospermia gse gse analysi deg found common teratozoospermia azoospermia interest sperm autoantigen protein spa found possess highest fold chang valu among deg coil coil domain contain b ccdcb coil coil domain contain ccdc gene found common among three analys ie network analyst exatla geor observ indic spa ccdcb ccdc gene might signific role play potenti biomark teratozoospermia azoospermia thus studi open new window research area provid import theoret basi diagnosi treatment diseas
|
D000072660;D053713;D007248
|
T033;T184;T047
|
36,292,605
|
character chloroplast genom argyranthemum frutescen comparison speci anthemidea argyranthemum frutescen belong anthemidea asteracea wide cultiv ornament plant studi complet chloroplast genom frutescen obtain base sequenc generat illumina hiseq chloroplast genom frutescen base pair bp length contain pair invert repeat ir bp region separ small singl copi ssc bp sequenc larg singl copi lsc bp sequenc genom contain gene consist code dna sequenc trna gene rrna gene nineteen gene duplic ir region comparison chloroplast genom analysi among ten speci tribe anthemidea reveal chloroplast genom size vari genom structur gene content oligonucleotid repeat high conserv high diverg region eg ycf trnk psbk petn psbm intron detect phylogenet analysi support argyranthemum separ genus find studi help explor phylogenet relationship tribe anthemidea contribut breed improv frutescen
|
D054628;D019659
|
T002;T028
|
36,292,604
|
molecular clone express respons jaridb high temperatur treatment nile tilapia oreochromi niloticus nile tilapia gsd te genet sex determin temperatur effect fish high temperatur treatment critic thermosensit period tsp induc sex revers nile tilapia genet femal brain transcriptom reveal upregul jarid jumonji rich domain contain express c high temperatur treatment day tsp shown jarid form complex polycomb repress complex prc catalyz hkme strong associ transcript repress studi jaridb clone character nile tilapia high conserv among analyz fish speci express jaridb upregul gonad dpf xx genet femal day high temperatur treatment reach similar level male similar respons high temperatur treatment also appear brain heart liver muscl eye skin tissu interest jaridb express respons high temperatur treatment methyltestosteron mt letrozol treatment although treatment also induc sex revers genet nile tilapia femal studi reveal jaridb respond rapid th hour high temperatur treatment consid jarid recruit prc establish hkme specul might upstream gene particip regul nile tilapia gsd te regul hk methyl level locus mani sex differenti relat gene
|
D023681
|
T013
|
36,292,603
|
genom wide identif membran bound fatti acid desaturas gene three peanut speci express arachi hypogaea drought stress crop irrig primarili rain qualiti yield peanut signific limit drought date mani studi indic fatti acid desaturas fad gene enhanc plant toler drought stress studi fad identifi arachi duranensi arachi ipaensi arachi hypogaea respect fad divid four subfamili relat conserv gene structur motif domain synteni relationship chromosom posit analysi show fad subgenom pair duranensi hypogaea aa ipaensi hypogaea bb homolog physic locat consist kak result indic nine fad gene underw purifi select ahfad experienc posit select tetraploid peanut speciat various cis act element relat hormon signal stress respons promot predict mirna target ahfad suggest gene play crucial role drought toler express profil ahfad tissu drought toler sensit cultivar drought stress suggest fad putat gene relat oil accumul drought respect find help provid insight potenti function role fad gene may aid deal plant drought stress
|
D010367;D035683
|
T123;T002;T114
|
36,292,602
|
methyl jasmon induc gene involv linalool accumul increas content phenol two iranian coriand coriandrum sativum l ecotyp medicin herb coriand coriandrum sativum l high linalool lin content wide recogn therapeut benefit novel report goal studi determin methyl jasmon meja affect total phenol content tpc lin content flavonoid content tfc chang gene express involv linalool biosynthesi pathway cstrps cslin find show comparison control sampl meja treatment substanti enhanc tpc lin tfc content ecotyp addit iranian coriand ecotyp treatment induc increas cstrps cslin express connect lin accumul treatment h treatment meja substanti increas lin content mashhad zanjan ecotyp time greater untreat plant accord gas chromatographi mass spectrometri gc ms analysi find demonstr meja signific affect accumul lin tpc tfc iranian c sativum treat meja like consequ gene activ monoterpen biosynthesi pathway discoveri improv understand molecular mechan behind lin synthesi coriand plant
|
D028526
|
T168;T002
|
36,292,601
|
temperatur chang implant osteotomi prepar human cadav tibia compar mis straight drill densah bur background sever studi show sustain temperatur c c one minut result vascular stasi bone resorpt limit bone regrowth week heal period purpos present studi evalu temperatur chang occur prepar dental implant osteotomi use mis straight drill versus densah bur clockwis cut drill protocol method two hundr forti osteotomi two differ system drill prepar mm depth revolut per minut rpm fresh unembalm tibia obtain femal cadav calcul subtract baselin temperatur tibial surfac maximum temperatur insid osteotomi tmax tbase variabl evalu individu synergist effect use one two three four way interact result independ three way interact drill design drill width rpm found three rpm densah bur rpm mis straight drill densah bur diamet increas decreas aforement pattern seen rpm mis straight drill usag drill time implant manufactur recommend signific affect stereoscop examin specimen confirm find conclus independ synergist effect drill diamet design rpm signific effect human tibia never exceed critic threshold c
|
D015921
|
T074
|
36,292,600
|
relationship substantia nigra neuromelanin imag dual alpha synuclein label labial minor salivari gland isol rapid eye movement sleep behavior disord parkinson diseas investig presenc misfold alpha synuclein syn minor salivari gland biopsi relat substantia nigra par compacta snc damag measur use magnet reson imag patient isol rapid eye movement sleep behavior disord irbd parkinson diseas pd compar healthi control sixti one particip pd irbd control underw minor salivari gland biopsi scan use tesla mri deposit syn found pd irbd control use anti aggreg syn clone g antibodi pd irbd control use purifi mous anti syn clone antibodi snc damag obtain use neuromelanin sensit imag differ particip versus without syn deposit irrespect antibodi diseas group studi indic syn detect minor salivari gland biopsi lack sensit specif correl snc damag suggest use predict effect biomark pd
|
D020187;D010300
|
T047;T048
|
36,292,599
|
tweak tnf tnf ligand famili member multipl sclerosi relat cytokin induc distinct gene respons human brain microvascular endotheli cell tumor necrosi factor like weak induc apoptosi tweak member tnf ligand famili involv various diseas includ brain inflammatori patholog multipl sclerosi demonstr tweak induc cerebrovascular permeabl vitro model blood brain barrier molecular mechan play role tweak versus tnf signal cerebr microvascular endotheli cell well defin therefor aim identifi gene express chang cultur human brain microvascular endotheli cell hcmecd address chang initi tweak exposur taken togeth studi highlight gene involv leukocyt extravas notabl claudin differenti modul tweak tnf identifi differenti gene express hcmecd cell three timepoint follow tweak versus tnf stimul also found distinct modul sever canon pathway includ actin cytoskeleton vascular endotheli growth factor vegf rho famili gtpase phosphatas tensin homolog pten pathway knowledg first studi interrog compar effect tweak versus tnf gene express brain microvascular endotheli cell
|
D009103;D014409
|
T129;T047;T116
|
36,292,598
|
dissect regulatori network maiz phase chang zmepc mutant transcriptom analysi development phase chang maiz close associ life span environment adapt plant height diseas resist plant eventu determin grain yield qualiti maiz natur mutant earli phase chang zmepc select inbr line kn compar wild type plant zmepc mutant exhibit deceas plant statur acceler development stage decreas leaf size transcriptom sequenc analysi leaf sampl flower stage total differenti express gene deg screen mutant wild type includ regul gene regul gene go enrich kegg enrich analysi reveal deg main involv hormon respons hormon signal transduct autophagi ja respons signal respons photosynthesi bioticabiot stress circadian rhythm rt qpcr result reveal test deg display consist express alter v ft stage howev sever gene show opposit express alter strike ja biosynthesi signal pathway relat gene display diametr express alter v ft stage mir key regul plant phase transit exhibit signific regul express v ft stage express two mir target gene signific differ mutant wild type conclus zmepc identifi main involv regul ja mediat signal pathway hormon respons signal possibl confer development phase chang mir spls pathway
|
D003313;D018506
|
T045;T168;T002
|
36,292,597
|
tierra del fuego left precoloni male lineag similar south american region tierra del fuego admix popul character distinct ancestor nativ american first occupi contin european settler arriv late th centuri onward sub saharan african brought america slave labor disclos patern lineag current popul tierra del fuego unrel male genotyp strs snps haplotyp haplogroup divers high indic absenc strong founder drift event high frequenc eurasian haplogroup detect follow nativ american african one haplogroup r abund sub haplogroup r take quarter total dataset compar analys latin american popul show similar admix popul argentina regard eurasian popul tierra del fuego present similar italian iberian popul depth analysi haplogroup r subtyp tierra del fuego display close proxim iberian peninsula result studi line histor record reflect sever demograph chang led main male newcom patern european origin
|
D044469;D020641
|
T098;T086
|
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