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biomedical-topic-categorization-validation

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36.4M
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101
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36,280,824
clinic characterist surviv outcom patient ovarian strumal carcinoid ovarian strumal carcinoid extrem rare ovarian malign tumor limit data clinic characterist surviv outcom
D002276;D010051;D013330
T191
36,280,823
dynam phosphotyrosin depend signal profil live cell two dimension proxim proteom tyrosin phosphoryl ptyr depend signal pathway play vital role various biolog process spatiotempor assembl dynam regul minut scale ptyr live cell studi ptyr mediat signal complex therefor challeng due high dynam natur protein complex low abund ptyr studi adopt minut resolut apex base proxim label pl live cell src sh superbind base ptyr peptid enrich simultan profil protein complex associ ptyr site affin purifi sampl upon differ time cours egf stimul live cell stabli express apex flag grb construct two dimension time cours curv interactom tyrosin phosphoproteom well annot ptyr signal complex egfr signal locat endosom quantifi tight correl time cours curv interact protein ptyr site import correl time cours curv egfr endosom hgs well valid target parallel reaction monitor prm ms analysi take advantag high sensit prm assay low abund ptyr peptid egfr py identifi data depend acquisit dda analysi could well quantifi collect two dimension proxim proteom strategi promis comprehens character ptyr mediat protein complex high sensit live cell
D040901;D001686
T070;T091;T038
36,280,822
qualit studi barrier facilit implement pilot school base toothbrush programm supervis toothbrush programm establish mani countri world littl known differ perspect implement aim studi explor stakehold barrier facilit implement school base toothbrush programm taiwan
D014099;D014100
T061;T122
36,280,821
preval metabol syndrom among adolesc india popul base studi india preval overweight among adolesc rise set stage increas metabol syndrom ms paper present nation preval ms adolesc india
D024821
T047
36,280,820
left side colorect cancer distinct indigen african patient compar ethnic group south africa larg proport indigen african ia colorect cancer crc patient south africa young year uniqu histopatholog molecular characterist anatom site well microsatellit instabl msi status shown associ differ clinicopatholog molecular featur studi aim ascertain key histopatholog featur microsatellit stabl mss low frequenc msi msi l patient provid insight mechan diseas
D005006;D015179
T098;T191;T102
36,280,819
develop feedback rich cultur academ medicin effect coach feedback physician leadership time unpreced chang healthcar physician task step varieti leadership role without receiv train need effect leader previous data demonstr effect leadership coach feedback tool foster physician well leadership growth proof concept studi explor combin effect two tool object studi examin effect brief physician leadership coach intervent percept profession dynam acquir leadership skill
D000071252;D010820
T065;T097
36,280,818
preval dental cari perman dentit amongst year old africa systemat review meta analysi dental cari dc high preval condit affect most young children systemat review done preval dc amongst year old africa although african countri report decreas dc preval other shown increas essenti measur current trend order identifi strategi programm could assist reduc dc africa aim systemat review determin preval dc condit amongst perman dentit year old children popul africa context
D019229;D003731
T033;T023;T047
36,280,817
implement evid manag pleural diseas insight territori wide survey clinician hong kong major advanc manag common pleural diseas taken place past decad howev pleural diseas often manag physician divers train background research implement new knowledg scanti aim evalu practic pattern pleural medicin among physician hong kong identif possibl gap clinic servic improv
D016066;D010995
T047
36,280,816
rethink ovari preserv adnex torsion revers adolesc case delay diagnosi articl discuss manag adolesc woman delay diagnosi adnex torsion whose ovari success preserv
D000291
T047
36,280,815
transesophag echocardiograph imag coronari sinus retrospect analysi mid esophag view novel transgastr view transesophag echocardiograph imag play import role assess coronari sinus anatomi prior placement retrograd cardioplegia cannula coronari sinus imag long axi advanc tee probe mid esophag chamber view use modifi mid esophag bicav view short axi view obtain mid esophag chamber view use transgastr view briefli mention literatur altern mid esophag view author common includ comprehens transesophag echocardiograph exam coronari sinus studi examin various imag strategi hypothes transgastr view offer compar coronari sinus imag mid esophag view
D054326
T023
36,280,814
psychometr properti public trust covid control prevent polici questionnair public trust crucial concept covid pandem determin public adher prevent rule success factor diseas manag studi aim develop valid tool measur public trust covid control prevent polici cov trust tool
D000086382
T047;T067
36,280,813
environment dna detect spawn habitat ephemer migrant fish anadrom rainbow smelt osmerus mordax anadrom rainbow smelt osmerus mordax experienc larg rang reduct recent decad status remnant spawn popul poor known main fish signific ecolog cultur commerci relev defin remnant rang anadrom smelt difficult mani declin fish speci adult ephemer present spawn small coastal stream night spring runoff period tradit assess unreli even hazard hypothes edna might facilit improv survey effort defin smelt spawn habitat detect could also face challeng adult edna quick flush small stream system combin daytim edna sampl nighttim fyke net ascertain potenti window edna detect conduct edna survey four stream vari abund hierarch occup model turn employ estim edna encount probabl relat number sampl event date sampl within event qpcr replic within sampl
D036441;D000080309
T114;T013
36,280,812
prospect random studi compar standard versus intens train strategi long term improv critic care ultrasonographi profici critic care ultrasonographi ccus becom daili diagnost tool intensivist effect train measur ultrasound novic discuss wide best curriculum novic retain long term profici yet determin
D002983;D003422;D014463
T060;T058;T080
36,280,811
base ct third lumbar spine level skelet muscl index psoa muscl index predict osteoporosi increas number studi osteoporosi muscl adipos tissu exist studi shown skelet muscl tissu adipos tissu close relat osteoporosi dual energi x ray absorptiometri dxa measur howev studi explor whether skelet muscl adipos tissu index measur lumbar spine l level close relat bone miner densiti bmd even predict osteoporosi therefor studi aim prove whether skelet muscl adipos tissu index measur comput tomographi ct imag base singl layer close relat bmd
D058866;D010024;D006620
T047;T037
36,280,810
nich differenti modul metabolit abund composit silicon fertil amend soil sugarcan growth one vital crop global sugarcan saccharum officinarum l one model crop conduct metabolom research although mani studi focus understand bioactiv compon specif sugarcan tissu crucial question left unansw respons metabolit nich differenti differ sugarcan tissu leaf stem root soil region rhizospher bulk silicon si amend soil nontarget metabolit profil method leverag assess similar differ abund communiti composit metabolit differ sugarcan soil compart identifi compart specif express pattern metabolit associ cane agronom trait edaph factor also investig respons sugarcan agronom trait edaph factor si amend soil
D031786
T002
36,280,809
effect ecd program caregiv parent knowledg attitud practic base cluster random control trial econom vulner area china first three year life critic sensit period format individu abil howev exist data indic earli childhood develop ecd econom vulner area china lag close relat lack parent knowledg poor parent practic
D016487;D017028
T099;T098;T097;T054
36,280,808
evalu feasibl communiti score card subsequ contracept behavior kisumu kenya women seek famili plan servic public sector facil low middl incom countri sometim face provid impos barrier care social account approach could address provid impos barrier empow communiti hold servic provid account servic qualiti yet littl known feasibl potenti impact effort context contracept care pilot social account intervent communiti score card csc three public healthcar facil western kenya use mix quantit qualit methodolog describ feasibl impact famili plan servic provis
D003268;D003267
T061;T055;T054
36,280,807
risk factor sudden cardiac arrest patient st segment elev myocardi infarct retrospect cohort studi sudden cardiac arrest sca critic complic acut myocardi infarct especi st segment elev myocardi infarct stemi studi identifi risk factor sca patient stemi receiv catheter
D000072657;D006323;D009203
T047;T046
36,280,806
decis make chang patient medic personnel manag acut append covid pandem acut append common caus acut abdomen pandem contain spread covid integr chang medic process base pandem prevent polici especi regard emerg surgeri studi conduct investig whether pandem also impact decis make patient medic personnel along treatment outcom
D001064;D000086382;D005244
T033;T047;T067;T031
36,280,805
develop compet base clinic assess instrument exit level oral hygien student univers western cape semin process health scienc curriculum evalu period review clinic assess instrument measur compet assess qualiti facilit use well structur authent reliabl instrument process rest design measur instrument sound framework valid scientif merit paper document pedagogi process taken develop improv format compet base assess instrument final year student bachelor oral health program boh univers western cape uwc
D003479;D009910;D003162;D003756
T078;T055;T170;T097;T065
36,280,804
efficaci safeti adapt opioid free anesthesia regimen versus convent general anesthesia gynecolog surgeri low resourc set random pilot studi scarc data safeti efficaci opioid free anesthesia ofa resourc limit set due non avail dexmedetomidin refer ofa agent aim demonstr feasibl efficaci safeti practic ofa protocol contain dexmedetomidin adapt low resourc environ pain surgeri like gynecolog surgeri
D015742;D007649;D020927;D007530
T121;T109
36,280,803
suicid behavior associ factor among prison dessi town correct institut dessi ethiopia suicid promin caus death among inmat worldwid account death sever factor includ prison relat psychiatr disord stress life event substanc use relat factor believ associ increas risk suicid behavior correct facil present studi aim determin preval associ factor suicid behavior among prison dessi town correct institut ethiopia
D011329;D019966
T033;T098;T048
36,280,802
clca overexpress suppress epitheli mesenchym transit cervic cancer cell inactiv erkjnkp mapk signal pathway cervic cancer import malign tumor threaten physic mental health women world new calcium activ chlorid channel protein calcium activ chlorid channel clca play import role tumorigenesi develop role exact regulatori mechan cervic cancer still unclear studi found clca signific decreas cervic cancer cell overexpress clca inhibit prolifer migrat invas promot apoptosi cervic cancer cell clca inhibit emt epitheli mesenchym transit p jnk erk pathway result vivo consist vitro conclus overexpress clca inhibit progress cervic cancer vivo vitro may provid theoret basi clca new indic clinic diagnosi prognosi cervic cancer potenti target drug therapi
D058750;D002583
T191;T043
36,280,801
hyperlipidemia mortal patient periton dialysi new lipid lower therapi start dialysi measur lipid paramet follow period recommend dialysi patient seem unappropri clinic practic aim examin effect hyperlipidemia mortal patient undergo continu ambulatori periton dialysi capd
D010530;D006949;D006973;D007676
T061;T047;T033
36,280,799
neural basi psychedel action psychedel serotonin receptor agonist lead profound chang percept cognit mood review focus basic neurobiolog under action psychedel drug first discuss chemistri highlight divers psychoact molecul principl govern potenc pharmacokinet describ role serotonin receptor downstream molecular signal pathway emphas key element drug discoveri consid impact psychedel neuron spike dynam sever cortic subcort region along transcript chang sustain effect structur plastic final summar neuroimag result pinpoint effect associ cortic thalamocort function connect inform current theori psychedel action synthes knowledg across chemic molecular neuron network level hope provid integr perspect neural mechan respons acut endur effect psychedel behavior
D006213
T121;T131
36,280,798
cd cell induc interferon respons oligodendrocyt microglia white matter age hallmark nervous system age declin white matter volum function under mechan lead white matter patholog unknown present studi found age relat alter oligodendrocyt cell state reduct total oligodendrocyt densiti age murin white matter use singl cell rna sequenc identifi interferon ifn respons oligodendrocyt local proxim cd cell age white matter absenc function lymphocyt decreas number ifn respons oligodendrocyt rescu oligodendrocyt loss wherea cell checkpoint inhibit worsen age respons addit identifi subpopul lymphocyt depend ifn respons microglia vicin cd cell age white matter summari provid evid cd cell induc ifn respons oligodendrocyt microglia import modifi white matter age
D017628;D066127
T023;T025;T024
36,280,797
reciproc cortico amygdala connect regul prosoci selfish choic mice decis favor one interest versus interest anoth individu depend context relationship individu neurobiolog under selfish choic choic benefit other understood develop two choic social decis make task mice decid whether share reward conspecif prefer altruist choic modul familiar sex social contact hunger hierarch status emot state match fiber photometri record chemogenet manipul demonstr basolater amygdala bla neuron involv establish prosoci decis particular bla neuron project prelimb pl region prefront cortex mediat develop prefer altruist choic wherea pl project bla modul self interest motiv decis make provid neurobiolog model altruist selfish choic relev patholog associ dysfunct social decis make
D000679;D066272
T023
36,280,786
coinfect influenza virus respiratori syncyti virus produc hybrid virus particl interact respiratori virus infect affect transmiss dynam clinic outcom identifi character virus virus interact cellular level coinfect human lung cell influenza virus iav respiratori syncyti virus rsv super resolut microscopi live cell imag scan electron microscopi cryo electron tomographi reveal extracellular membran associ filament structur consist hybrid viral particl hvps found hvps harbour surfac glycoprotein ribonucleoprotein iav rsv hvps use rsv fusion glycoprotein evad anti iav neutral antibodi infect spread among cell lack iav receptor final show iav rsv coinfect primari cell bronchial epithelium result viral protein virus co local apic cell surfac observ defin previous unknown interact respiratori virus might affect virus pathogenesi expand virus tropism enabl immun evas
D009980;D018357;D060085;D018113
T005;T047
36,280,785
dual ancestri ecolog late glacial palaeolith britain genet investig upper palaeolith europ reveal complex transform histori human popul movement ancestri evid sever instanc genet chang across european contin period follow last glacial maximum lgm concurr genet shift post lgm period character seri signific climat chang popul expans cultur diversif britain lie extrem northwest corner post lgm expans earliest late glacial human occup remain unclear present genet data palaeolith human individu unit kingdom oldest human dna thus far obtain britain ireland determin late upper palaeolith individu gough cave probabl trace ancestri magdalenian associ individu close relat site el mirn cave spain troisim cavern goyet belgium howev individu kendrick cave show evid ancestri relat gough cave individu instead kendrick cave individu trace ancestri group expand across europ late glacial repres site villabruna itali furthermor individu differ genet ancestri profil also mortuari practic diet ecolog evidenc stabl isotop analys find mirror pattern dual genet ancestri admixtur previous detect iberia may suggest drastic genet turnov northwestern europ southwest
D059552;D004463
T090;T083
36,280,783
influenc social cue time anim migrat anim migrat play central role mani ecolog evolutionari process yet migratori popul worldwid increas threaten adjust migrat time match ecosystem phenolog key surviv dynam chang ecosystem especi era human induc rapid environment chang social cue increas recogn major compon migratori behaviour yet comprehens understand social cue influenc time anim migrat remain elus introduc framework assess role social cue rang explicit exampl activ cue implicit exampl competit play anim tempor migrat decis across rang scale appli theoret len systemat review publish literatur show broad rang social cue frequent mediat migrat time rang tempor scale across high divers migratori taxa highlight rare document sever social cue mechan exampl social learn densiti depend play import adapt role match migrat time ecosystem dynam thus social cue play fundament role migrat time potenti widespread ecolog consequ implic conserv migratori speci furthermor analysi establish theoret basi evalu futur find role conspecif interspecif social cue intersect behaviour ecolog global chang biolog
D025041;D017753
T053;T070;T082
36,280,778
develop ex vivo porcin lower urinari tract model evalu perform urinari cathet intermitt catheter gold standard method bladder manag individu urinari retent andor incontin therefor import understand perform urinari cathet especi paramet associ risk develop urinari tract infect may impact qualiti life urinari cathet user exampl paramet includ urin flowrat occurr flow stop residu urin left bladder flow stop reliabl vitro andor ex vivo laboratori model repres strong asset assess perform urinari cathet preced guid vivo anim studi andor human clinic studi exist laboratori model general simplifi cover portion catheter process poor reflect clinic procedur work develop ex vivo porcin lower urinari tract model better reflect catheter procedur human allow investig perform standard care cathet perform three standard care cathet investig develop model show signific differ term flowrat differ detect term residu volum bladder first flow stop also tune abdomin pressur mimic sit stand posit newli discov phenomenon name hammer detect measur last mucos suction observ measur standard care cathet rais concern microtrauma catheter need new improv urinari cathet design result obtain ex vivo model compar vivo studi highlight similar concern
D014552;D016055
T033;T047
36,280,777
heterolog secret mbxa moraxella bovi induc membran bleb respons human host cell mani protein repeat toxin rtx protein famili toxin gram negat pathogen includ hemolysin hlya uropathogen e coli rtx protein secret via type secret system tss adopt nativ conform ca rich extracellular environ employ e coli hlya tss heterolog surrog system rtx toxin mbxa bovin pathogen moraxella bovi e coli hlya system success activ heterolog mbxa substrat acyl secret precursor prombxa activ mbxa allow purif speci quantiti suffici varieti investig activ e coli acyltransferas hlyc recogn acyl site mbxa unexpect differ acyl pattern endogen substrat hlya hlyc activ mbxa show host speci independ activ includ far unknown toxic human lymphocyt epitheli cell use live cell imag show immedi mbxa mediat permeabil rapid develop bleb plasma membran epitheli cell associ immedi cell death
D001426;D016955
T123;T007;T116
36,280,775
nestin marker unipot embryon adult progenitor differenti epitheli cell lineag hair follicl nestin intermedi filament protein transient express neural stemprogenitor cell previous demonstr outer root sheath or keratinocyt adult hair follicl hfs mice descend nestin express cell despit epitheli cell lineag studi determin exact stage nestin express or stemprecursor cell descend appear hf morphogenesi whether present adult hfs use nes crecag cat egfp mice enhanc green fluoresc protein egfp express follow cre base recombin driven nestin promot found egfp cell appear epitheli layer embryon hfs earli peg stage egfp cell hair peg posit keratin k k vimentin sox sox alpha trace tamoxifen induc egfp cell postnat nes creertcag cat egfp mice reveal label isthmus hf epitheli cell first anagen stage egfp cell adult hfs immunolabel k hf multipot stem cell marker howev hair depil nes creertcag cat egfp mice induc anagen stage tamoxifen inject major or keratinocyt depil induc anagen hfs label egfp find indic nestin express unipot progenitor cell capabl differenti or keratinocyt present hf primordia adult hfs
D004847;D018859;D064231
T123;T023;T116;T025
36,280,774
caveolin primari determin endotheli stiffen associ dyslipidemia disturb flow age endotheli stiff emerg major determin endotheli function analyz role caveolin cav determin stiff endotheli cell ec expos oxid low densiti lipoprotein oxldl static hemodynam condit vitro aortic endothelium vivo mous model dyslipidemia age elast moduli cultur ec endotheli monolay fresh isol mous aorta measur use atom forc microscopi afm found loss cav abrog uptak oxldl oxldl induc endotheli stiffen well endotheli stiffen induc disturb flow df also oxldl depend mechanist cav requir express cd cluster differenti scaveng receptor genet delet cav abrog endotheli stiffen observ df region aortic arch induc high fat diet week signific blunt endotheli stiffen develop advanc age effect independ stiffen sub endothelium layer addit cav express signific increas age differ elast modulus observ sex advanc age wild type cav knockout mice taken togeth studi demonstr cav play critic role endotheli stiffen induc oxldl vitro dyslipidemia disturb flow age vivo
D051242;D050171
T123;T116;T192;T047;T046
36,280,773
surviv analysi local prostat cancer deep learn recent year data driven deep learn base model shown great promis medic risk predict util larg scale electron health record data found us depart veteran affair largest integr healthcar system unit state develop autom person risk predict model support clinic decis make process local prostat cancer patient method combin repres power deep learn analyt interpret parametr regress model implement time depend static input data collect comprehens evalu model perform calcul time depend c statist formula see text year time horizon use either composit outcom prostat cancer mortal target event composit outcom combin prostat specif antigen psa test metastasi prostat cancer mortal longitudin model recurr deep surviv machin rdsm achiev formula see text cross section model deep surviv machin dsm attain formula see text year composit mortal outcom respect addit estim surviv probabl method quantifi uncertainti associ predict uncertainti score show consist correl predict accuraci find psa prostat cancer stage inform import indic risk predict work demonstr util data driven machin learn model prostat cancer risk predict play critic role clinic decis system
D000077321;D011471
T191;T066
36,280,772
size character plasmon nanoparticl dark field singl particl spectrophotometri plasmon nanoparticl wide use multipl scientif industri applic although mani synthesi method report literatur throughout last decad control size shape larg popul still remain challeng size shape variat strong impact plasmon properti need metrolog techniqu accur character morpholog featur peremptori present new optic method refer dark field singl particl spectrophotometri abl measur individu size thousand particl nanometr accuraci coupl minut method also featur easi sampl prepar straightforward experiment setup inspir custom optic microscop measur protocol simpl enough carri untrain technician proof concept thousand spheric nanoparticl differ size measur direct comparison metrolog gold standard electron microscopi discrep attest although feasibl demonstr spheric nanoparticl true strength method general also nanoparticl arbitrari shape geometri thus repres advantag altern gold standard electron microscopi
D053768
T073
36,280,771
habitu visual acuiti visual acuiti threshold demand nigerian school classroom studi design estim burden blind vision impair school children determin proport student meet visual acuiti va demand classroom primari secondari school classroom edo state nigeria habitu distanc near va student measur valu obtain compar calcul distanc va demand actual near va demand classroom measur use calcul va demand work distanc smallest text size learn materi distanc near also determin relationship age calcul va demand effect factor school ownership school type va demand habitu distanc vision impair found pupil includ met criteria blind averag va demand furthest nearest sit posit board logmar respect near work distanc student rang cm near va demand well actual near va demand use time acuiti reserv logmar respect logmar va demand increas size print decreas increas age distanc r p near r p va demand maximum distanc actual near va demand differ signific school ownership primari secondari school student va better student per class va poorer classroom demand although major student better va classroom demand student reduc vision learn could negat impact import continu screen student vision impair ensur prompt referr treatment find implic manag vision problem children well enabl appropri classroom arrang vision impair
D015354
T047
36,280,748
hpv genotyp versus convent cervic cytolog screen method detect dysplast cervic epitheli chang world health organ call coordin global action elimin cervic cancer ensur everi woman screen treat precancer lesion world health organ cervic cancer ncd overcom geneva http wwwwhointdirector generalspeechesdetailcerv cancer ncd overcometegi cytolog base screen decad convent method screen ancillari techniqu ad like immunocytochemistri pki l capsid method requir mainten complex infrastructur high train personnel well relat short screen interv hpv base screen method detect high risk group faster autom method need morpholog high qualifi person high social cost studi focus distribut cervic lesion age group concord detect hpv high risk subtyp hpv hr safeti screen method institut patholog cytolog schuettorf leer germani sampl women age year analyz begin begin case year old analyz sampl process convent cytolog techniqu molecular detect subtyp hpv hr accord advic measur bd manufactur studi studi histopatholog result tabl colposcopi accord age subgroup histopatholog result subdivid dysplasia cervic intraepitheli neoplasia cin cervic intraepitheli neoplasia ii cin ii cervic intraepitheli neoplasia iii cin iii squamous cell carcinoma sqcc adenocarcinoma situ ai endometri carcinoma endocerv adenocarcinoma case without biopsi colposcopi cob use muenchen classif iii tabl subgrad system cytolog specimen frequenc detect hpv higher detect hpv hpv age group year old year old year old hpv detect higher age group year old year incid high squamous intraepitheli lesion cin ii iii age group year age year age group year old age group year old age group year old signific p valu low grade cervic lesion cin statist signific p valu without dysplasia ys signific occurr cervic dysplasia without dysplasia despit detect hpv hr subtyp p valu use hpv subtyp secur method protect way women worldwid mani hpv posit case psycholog impair higher cost although cervic epitheli chang hpv infect mani hpv negat case studi case develop cervic cancer opinion convinc screen morpholog via cytolog examin may ad immunocytochemistri detect realli dysplast cervic lesion hpv subtyp may ad everi three year detect concomit subtyp
D030361;D018290;D002583;D002578
T047;T191
36,280,747
mous tissu glycom atlas highlight inter organ variat major n glycan profil studi present mous tissu glycom atlas repres profil major n glycan mous glycoprotein may defin essenti function surfac glycocalyx mous organstissu serum deriv extracellular vesicl exosom cell surfac glycocalyx compos varieti n glycan attach coval membran protein notabl characterist n glycosyl pattern glycocalyx play critic role regul cell differenti cell adhes homeostat immun respons biodistribut secret exosom given integr cell surfac glycocalyx correl signific mainten cellular morpholog homeostat immun function dynam alter n glycosyl pattern normal glycocalyx caus cellular abnorm may serv high sensit promis biomark although believ inter organ variat n glycosyl pattern exist inform glycan divers mous organstissu remain elus communic first time n glycosyl pattern mous organstissu serum serum deriv exosom slc ddi mice use establish solid phase glycoblot platform rapid easi high throughput maldi tofm base quantit glycom present result elicit occurr organtissu characterist n glycosyl pattern discrimin basic machin learn analysi use n glycom dataset enabl classif mous organstissu highest f score neural network algorithm use preliminari examin demonstr machin learn analysi mous lung n glycom dataset random forest algorithm allow discrimin lung among differ mous strain outbr mous slc ddi inbr mous dbacrslc system lupus erythematosus model mous mrl lprlpr highest f score result strong implic import human organtissu glycom atlas understand crucial diversifi role glycocalyx determin organtissu characterist n glycosyl pattern discoveri research n glycom base diseas specif biomark therapeut target
D006023;D011134
T123;T121;T116;T109
36,280,746
model spatiotempor spread covid case recoveri death effect partial full vaccin coverag canada purpos studi map high risk area canada well quantifi effect vaccin intervent socio demograph factor transmiss rate infect recoveri death relat covid data research includ week number covid case recov dead individu canada health region provinci level data associ cumul rate partial full vaccin socio demograph factor appli spatio tempor suscept expos infect remov seir suscept expos infect remov vaccin seirv model result indic partial vaccin rate greater effect compar full vaccin rate decreas rate infecti case risk ratio rr cri rr cri respect increas rate recov case rr cri rr cri respect howev mortal risk reduct increas full vaccin rate signific associ rr cri addit result show region higher rate elder aborigin individu higher popul densiti lower socioeconom status ses contribut risk infect transmiss rate elder aborigin individu ses region signific associ recoveri rate howev elder individu rate region signific predictor mortal risk base result protect mild sever covid infect primari vaccin seri decreas
D000086382
T047;T067
36,280,724
clampfish enabl rapid scalabl amplifi rna detect situ rna label situ enorm potenti visual transcript quantifi level singl cell remain challeng produc high level signal also enabl multiplex detect multipl rna speci simultan describ clampfish method use invert padlock design effici detect mani rna speci exponenti amplifi signal also reduc time cost compar prior clampfish method leverag increas throughput afford multiplex signal amplif sequenti detect detect differ rna speci million cell also show clampfish work tissu section expect advantag offer clampfish enabl mani applic spatial transcriptom
D012313;D059467
T081;T114;T086
36,280,722
geometr engin organoid cultur enhanc organogenesi dish introduc facil scalabl engin approach enabl long term develop matur organoid redesign configur convent organoid cultur develop platform convert singl inject stem cell suspens radial array organoid maintain extend period without need passag use system demonstr acceler product intestin organoid signific enhanc structur function matur continu develop week furthermor present patient deriv organoid model inflammatori bowel diseas ibd interrog use singl cell rna sequenc demonstr abil reproduc key patholog featur ibd final describ extens approach engin vascular perfus human enteroid use model innat immun respons ibd work provid immedi deploy platform technolog toward engin realist organ like structur dish
D009940;D015212
T047;T024
36,280,721
multi purpos regener proteom scale human phosphoserin resourc phosphoproteom mass spectrometri base phosphoproteom becom indispens understand cellular signal complex biolog system despit central role protein phosphoryl field still lack inexpens regener divers phosphopeptid ground truth phosphoryl posit present iter synthet phosphoryl isom ispi proteom scale librari human deriv phosphoserin contain phosphopeptid inexpens regener divers precis known posit phosphoryl demonstr possibl use ispi includ use phosphopeptid standard tool evalu optim phosphoryl site local algorithm benchmark compar perform across data analysi pipelin also present ascorepro updat version ascor algorithm specif optim phosphoryl site local higher energi fragment spectra flr viewer web tool phosphoryl site local enabl communiti use ispi resourc ispi associ data constitut use multi purpos resourc phosphoproteom communiti
D020543;D010748
T123;T116
36,280,720
annot spatial resolv singl cell data stellar accur cell type annot spatial resolv singl cell crucial understand function spatial biolog basi tissu organ howev current comput method annot spatial resolv singl cell data typic base techniqu establish dissoci singl cell technolog thus take spatial organ account present stellar geometr deep learn method cell type discoveri identif spatial resolv singl cell dataset stellar automat assign cell cell type present annot refer dataset discov novel cell type cell state stellar transfer annot across differ dissect region differ tissu differ donor learn cell represent captur higher order tissu structur success appli stellar codex multiplex fluoresc microscopi data multiplex rna imag dataset within human biomolecular atlas program stellar annot million spatial resolv singl cell dramat time save
D059010
T059
36,280,719
coda quantit reconstruct larg tissu cellular resolut central challeng biolog obtain high content high resolut inform analyz tissu sampl volum relev diseas progress address coda method reconstruct except larg multicentimet cube tissu subcellular resolut use serial section hematoxylin eosin stain tissu section demonstr coda abil reconstruct three dimension distinct microanatom structur pancrea skin lung liver tissu coda allow creation readili quantifi tissu volum amen biolog research testb assess microanatomi human pancrea tumorigenesi within branch pancreat ductal system label ten distinct structur examin heterogen structur transform neoplast progress show pancreat precancer lesion develop distinct morpholog phenotyp pancreat cancer tend spread far bulk tumor along collagen fiber high align curv ductal lobular vascular neural structur thus coda establish mean transform broad structur studi human diseas explor exhaust label microarchitectur
D021621;D010190
T062;T060;T191;T073
36,280,718
resolut doubl light sheet microscopi via obliqu plane structur illumin structur illumin microscopi sim doubl spatial resolut fluoresc microscop without requir high laser power special fluorophor howev excit focus fluoresc acceler photobleach phototox contrast light sheet fluoresc microscopi lsfm larg avoid excit focus fluoresc therebi enabl volumetr imag low photobleach intrins optic section combin sim lsfm would enabl gentl three dimension imag doubl resolut howev multipl orient illumin pattern need isotrop resolut doubl sim challeng implement light sheet format show multidirect structur illumin implement obliqu plane microscopi lsfm techniqu use singl object excit detect straightforward manner demonstr isotrop later resolut nm combin lower phototox compar tradit sim system volumetr acquisit speed exceed hz
D021621;D008029
T062;T068;T060;T073
36,280,717
autom synaps level reconstruct neural circuit larval zebrafish brain dens reconstruct synapt connect requir high resolut electron microscopi imag entir brain tool effici trace neuron wire across volum generat resourc section imag larval zebrafish brain serial block face electron microscopi voxel size nm segment result dataset flood fill network algorithm autom detect chemic synaps valid result comparison transmiss electron microscop imag light microscop reconstruct neuron connect store form queryabl expand digit address book reconstruct network neuron involv visual motion process locat pretectum function character specimen two photon calcium imag moreov map presynapt postsynapt partner two superfici interneuron tectum resourc develop serv foundat synapt resolut circuit analys zebrafish nervous system
D015027;D013569
T030;T013
36,280,715
syconn dens synapt connect infer volum electron microscopi abil acquir ever larger dataset brain tissu use volum electron microscopi lead increas demand autom extract connectom inform introduc syconn open sourc connectom analysi toolkit work site high perform comput environ rentabl cloud comput cluster syconn test connectom dataset million synaps provid web base visual interfac make data amen complex anatom neuron connect queri
D063132
T017;T091
36,280,703
templat encapsul platinum base catalyst promot high temperatur stabil c stabl catalyst essenti address energi environment challeng especi applic harsh environ exampl high temperatur oxid atmospher steam condit support metal catalyst deactiv due sinter process initi small nanoparticl grow larger one reduc activ surfac area strategi stabil lead decreas perform report stabl catalyst prepar encapsul platinum nanoparticl insid alumina framework form deposit alumina precursor within separ prepar porous organ framework impregn platinum nanoparticl catalyst sinter c presenc oxygen steam condit convent catalyst sinter larg extent show similar reaction rate extend approach pd pt bimetal catalyst led small particl size maintain temperatur high c air steam strategi broad appli metal metal oxid applic sinter major caus materi deactiv
D010984;D053768
T196;T073
36,280,701
generic predict exocytosi rate constant size base surfac energi nanoparticl cell nanotechnolog bring benefit field biomedicin nanoparticl nps may also advers health effect effect surfac modifi nps cellular level major implic medicin toxicolog semi empir mechan base model aid understand cellular transport various nps implic quantit biolog exposur avoid larg scale experi hypothes relationship nps cellular elimin surfac function elimin pathway cell surfac free energi compon use character transport nps onto membran lipid vesicl cover influenc size hydrophob nps model built base properti neutral nps cell defin van de waal forc electrostat forc lewi acid base polar interact nps vesicl well vesicl cell membran yield generic model estim exocytosi rate constant various neutral nps cell base vesicl transport exocytosi pathway result indic model well fit r rang may provid good predict exocytosi rate constant nps differ surfac function predict error within time macrophag exocytosi rate differ cancer cell metastat potenti non cancer cell model provid refer cellular elimin nps intend medic applic risk assess
D058116;D053758
T197;T073
36,280,698
cytogenet molecular insight genet background disord sex develop seventeen cat genet background felin disord sex develop dsds poor understood perform comprehens cytogenet molecular histolog studi cat abnorm extern genitalia unusu behavior tricolor coat atyp male dsd phenotyp three cat associ sex chromosom abnorm xy transloc xx sri x xy mosaic xxxi leukocyt chimer remain affect cat classifi xy dsd sri posit group normal male analyz priori select candid gene sri tac cypb lhcgr previous report nonpathogen variant found sri moreov sri gene copi number determin three variant observ modal copi singl dsd case known variant tac cypb respons testicular hypoplasia persist primari dentit congenit adren hyperplasia found studi group nine novel polymorph identifi lhcgr gene one potenti regulatori indel variant utr signific associ p xy dsd report confirm abnorm sex chromosom import caus felin dsds also show indel variant lhcgr consid promis marker associ xy dsd phenotyp
D013252;D012734
T116;T019;T126;T054;T047
36,280,697
associ postpartum pain mood matern infant attach parent outcom pain depress interrel wors postpartum pain associ postpartum depress remain unclear whether improv pain mood deliveri also improv matern parent studi examin relationship postpartum pain negat mood anxieti depress effect parent infant relationship outcom purpos studi explor relationship postpartum pain mood parent infant attach parent self efficaci infant develop prospect longitudin observ pilot studi nullipar women enrol third trimest present labor deliveri term gestat baselin third trimest assess includ valid inventori pain brief pain inventori bpi depress edinburgh postnat depress screen epd anxieti state trait anxieti inventori stai multidimension scale perceiv social support perceiv social support scale mspss perceiv stress scale pss demograph labor characterist record week month postpartum self report assess includ epd stai bpi matern parent infant attach scale mpas perceiv matern parent self efficaci pmp se child develop outcom assess week month use age stage questionnair asq univari linear regress assess relationship pain parent outcom mpas pmp se includ potenti interact pain mood parent outcom general linear model use explor relationship postpartum pain parent outcom child develop outcom subject complet data parent infant attach parent self efficaci data month lower pain right score bpi postpartum day associ higher matern infant attach mpas week postpartum estim ci p month estim ci p higher depress epd score week also associ lower mpas score week estim ci p howev evid relationship pain mpas vari depress score week p pain score baselin six week three month correl parent outcom mpas pmp se six week three month result general linear model reveal relationship pain age anxieti stai depress epd predictor outcom parent mpas pmp se gross motor person social asq aspect infant develop pattern associ wors postpartum pain anxieti depress wors parent outcom depress pain may also affect infant develop futur work requir replic character potenti relationship
D016487;D019052
T054;T048
36,280,696
feel loneli covid specif health anxieti depress symptom first covid wave swiss person multipl sclerosi aim studi investig whether self report feel loneli fol covid specif health anxieti associ presenc depress symptom first coronavirus diseas covid wave questionnair person swiss multipl sclerosi registri smsr cross section analyz use descript multivari regress method survey respons rate depress symptom assess beck depress inventori fast screen bdi fs covid specif health anxieti fol measur use two item likert scale pertin question high score fol confid interv ci andor covid specif health anxieti ci signific associ depress symptom stratif analysi show impact fol depress symptom affect age group howev pronounc younger pwms wherea impact covid specif health anxieti depress symptom particular observ middl age pwms fol covid specif health anxieti age depend associ depress symptom first covid wave switzerland find could guid physician health author self help group better accompani pwms time public health crise
D000086382;D009103
T047;T067
36,280,695
protect status human disturb snow cover trap drive densiti declin wolverin popul canadian rocki mountain protect area import speci conserv high rate human caus mortal outsid border increas popular recreat negat affect wildlif popul quantifi wolverin gulo gulo popul trend km protect non protect habitat southwestern canada conduct wolverin multi speci survey use non invas dna remot camera base method develop bayesian integr model combin spatial captur recaptur data mark unmark individu occup data wolverin densiti occup declin annual popul growth rate densiti within protect area time higher outsid declin wolverin km wolverin km wolverin densiti detect probabl increas snow cover decreas near develop detect probabl also decreas human recreat activ annual harvest rate maximum sustain rate conclud human negat affect popul direct mortal sub lethal effect habitat impact studi exemplifi need monitor popul trend speci risk within protect area steep declin occur unnot key conserv concern identifi address
D045969
T015
36,280,694
comparison adipos anthropometr indic associ viscer fat level determin bioelectr imped analysi among diabet patient viscer fat vf effect metabol disord extens studi nevertheless need simpl reliabl index equal assess vf low resourc set multihospit base studi design compar five adipos anthropometr indic associ vf level determin bioelectr imped analysi refer standard among diabet patient pretest questionnair use collect anthropometr biochem hemodynam data diabet patient regress analysi perform determin associ five adipos anthropometr indic vf level receiv oper characterist roc curv use confirm predict capac five adipos anthropometr indic vf level waist height ratio whtr show greatest roc valu area curv auc p identifi diabet patient high vf level compar bodi mass index bmi auc p waist circumfer wc auc p hip circumfer hc auc p waist hip ratio whr auc p likewis regress analysi whtr vf level reveal strongest associ unadjust odd ratio uor p compar bmi uor p wc uor p hc uor p whr uor p whr whtr shown overpow bmi hc wc whr identifi diabet patient high vf level therefor ghana health servic could recommend whtr better diagnost index assess vf level due high predict capac
D050154;D003920
T047;T032
36,280,693
improv resnet sign languag recognit algorithm enhanc hand featur sign languag video hand region small resolut low motion speed fast cross occlus blur phenomena great impact sign languag recognit rate speed import factor restrict sign languag recognit perform solv problem paper propos improv resnet sign languag recognit algorithm enhanc hand featur aim highlight featur hand solv problem miss effect inform reli global featur improv accuraci sign languag recognit propos method two improv first algorithm detect left right hand region base improv efficientdet network use improv bi fpn modul dual channel spatial attent modul use enhanc detect abil network small target like hand second improv residu modul use improv resnet network extract sign languag featur global left hand right hand imag sequenc divid three branch featur extract fusion strengthen attent hand featur strengthen represent abil sign languag featur achiev purpos improv accuraci sign languag recognit order verifi perform algorithm seri experi carri csl dataset exampl experi hand detect algorithm sign languag recognit algorithm perform indic top n map flop parm appli find optim algorithm framework experiment result show top recognit accuraci algorithm reach higher cd pd resnet basic network perform indic top n map flop parm perform algorithm paper better sever algorithm recent three year idblstm bd resnet rescdrcnn result show hand detect network enhanc hand featur three dimension convolut neural network propos paper achiev higher accuraci sign languag recognit
D012813;D000465
T171;T170
36,280,692
rockmlc inhibit induc decay viral mrna bpxv infect cell rho associ coil coil contain protein kinas rock intracellular cell signal pathway regul cell morpholog polar cytoskelet remodel observ activ rockmyosin light chain mlc signal pathway buffalopox virus bpxv infect vero cell rock deplet sirna specif small molecul chemic inhibitor thiazovivin result reduc bpxv replic evidenc reduct viral mrnaprotein synthesi genom copi number progeni virus particl demonstr rock inhibit promot deadenyl viral mrna mrna decay mediat via inhibit interact pabp poli bind protein enhanc express ccr multi protein complex play import role deadenyl mrna addit rockmlc mediat cell contract perinuclear accumul p mlc shown posit correl viral mrnaprotein synthesi final demonstr long term sequenti passag p bpxv presenc thiazovivin select drug resist virus variant conclus rockmlc cell signal pathway facilit bpxv replic prevent viral mrna decay inhibitor target pathway may novel therapeut effect buffalopox
D054460;D014616
T005;T126;T116
36,280,691
chang spatial tempor characterist china arid region background enso arid region sensit chang precipit el nio southern oscil strong influenc worldwid hydrometeorolog process tempor spatial chang characterist includ precipit annual mean temperatur area china arid region analyz use daili precipit temperatur data meteorolog station result show arid region get warmer wetter past year precipit arid region shown increas trend annual quarter precipit exist cycl year negat correl area arid region annual mean temperatur signific level area arid region downward trend sinc mutat three main cycl year year year area arid region studi period spatial center arid region precipit move north east respons precipit enso differ eastern western arid region el nio event increas area china arid region el nio year la nia event increas precipit china arid region la nia year respons china arid region enso first half follow year opposit respons spring signific sum el nio year eastern arid region increas area precipit la nia year western arid region decreas area eastern arid region increas precipit relat eastward movement spatial center precipit
D059000
T070
36,280,690
genet polymorph bin rather apo associ poor recognit memori among men without dementia although sever genet polymorph link risk alzheim diseas less known impact cognit perform among cognit healthi individu aim investig associ genet variant rs bridg integr gene bin strongest genet risk factor alzheim diseas apo allel differ cognit domain among non dement older men cognit function measur use cogstat brief batteri assess cognit perform across four domain psychomotor function visual attent recognit memori work memori linear regress analysi reveal individu bin risk allel perform poor recognit memori task compar without risk allel howev contrast individu harbour apo risk allel display better perform recognit task comparison without risk allel best knowledg first studi demonstr genet variat bin better predictor recognit memori apo remain biggest genet risk factor alzheim diseas
D000544
T047;T048
36,280,687
comput pharmacogenom screen identifi drug potenti anti breast cancer activ statin statin famili fda approv cholesterol lower drug inhibit rate limit enzym mevalon metabol pathway demonstr anticanc activ evid show dipyridamol potenti statin induc cancer cell death block restor feedback loop trigger statin treatment leverag knowledg develop integr pharmacogenom pipelin identifi compound similar dipyridamol level drug structur cell sensit molecular perturb overcom complex polypharmacolog dipyridamol focus pharmacogenom pipelin mevalon pathway gene name mevalon drug network fusion mva dnf valid top rank compound nelfinavir honokiol identifi low express canon epitheli cell marker e cadherin associ statin compound synergi analysi remain priorit hit led valid addit compound clotrimazol vemurafenib thus comput pharmacogenom approach identifi action compound pathway specif activ
D019161;D001943
T121;T191;T109
36,280,685
ribosom mediat biosynthesi pyridazinon oligom vitro ribosom macromolecular machin catalyz sequenc defin polymer l amino acid polypeptid catalysi peptid bond format amino acid substrat base entropi trap wherein adjac transfer rna trna coupl acyl bond p site amino group site align substrat coupl plastic catalyt mechan observ remnant evolut genet code modern effort reprogram genet code eg ribosom incorpor non canon amino acid ribosom ester format howev limit ribosom mediat polymer underexplor rather peptid bond demonstr ribosom mediat polymer pyridazinon bond via cyclocondens reaction activ keto hydrazino ester monom addit demonstr ribosom catalyz synthesi peptid hybrid oligom compos multipl sequenc defin altern pyridazinon linkag result highlight plastic ribosom ancient bond format mechan expand rang non canon polymer backbon synthes ribosom open door new applic synthet biolog
D012270;D012343
T026;T123;T114
36,280,684
induc pluripot stem cell endang avian speci number endang avian relat speci increas japan recent applic new technolog induc pluripot stem cell ipsc may contribut recoveri decreas number endang anim conserv genet resourc establish novel ipsc three endang avian speci okinawa rail japanes ptarmigan blakiston fish owl seven reprogram factor mo sox klf c myc nanog lin klf ipsc pluripot marker express pluripot relat gene differenti three germ layer vivo vitro three endang avian ipsc display differ cellular characterist even though reprogram factor use japanes ptarmigan deriv ipsc differ biolog characterist observ avian deriv ipsc japanes ptarmigan ipsc contribut chimera part chicken embryo best knowledg find provid first evid potenti valu ipsc resourc endang avian speci conserv
D057026
T025
36,280,682
pretreat terahertz absorpt curv narrow undul constraint quick implement suggest convex hull work method pretreat thz absorpt curv propos lead minim rang absorpt reserv necessari undul curv identif convolut neural network kernel thought propos method confin undul curv pair narrow parallel line solv optim posit consecut rotat normal curv two fix point fast algorithm propos base featur convex hull whose procedur describ detail algorithm involv definit import point set calcul compar slope determin best choic potenti rotat ration search critic point illustr geometr way addit adapt method discuss real exampl given show capac method extract nonlinear inform curv studi suggest method regard comput graphic also contribut featur extract respect thz curv pattern recognit
D000465;D016571
T170
36,280,678
estim best correct visual acuiti base deep neural network studi investig convolut neural network cnn base framework estim best correct visual acuiti bcva fundus imag first collect fundus photograph gyeongsang nation univers changwon hospit fundus photograph categor level retrospect medic chart review design bcva estim scheme use transfer learn pre train resnet efficientnet b model regress classif base predict taken account accord result studi predict bcva cnn base scheme close actual valu predict accuraci achiev level differ toler predict mean squar error formula see text score measur respect result indic bcva predict accur extrem case ie level bcva close either moreov use guid grad cam confirm macula blood vessel surround macula main util predict bcva valid ration cnn base bcva estim scheme sinc area also exploit retrospect medic chart review final appli distribut stochast neighbor embed examin characterist cnn base bcva estim scheme develop bcva estim scheme employ obtain object measur bvca well medic screen peopl poor access medic care smartphon base fundus imag
D016571;D008266
T023;T170
36,280,677
de novo transcriptom assembl differenti express analysi catharanthus roseus respons salicyl acid anti cancer vinblastin vincristin alkaloid natur found periwinkl catharanthus roseus alkaloid accumul known influenc salicyl acid sa transcriptom data reveal induct effect sa howev seem restrict time studi de novo approach transcriptom assembl perform rna sequenc rna seq data c roseus outcom demonstr sa treatment boost express gene terpenoid indol alkaloid tia pathway produc vinblastin vincristin alkaloid outcom support time cours measur vincristin alkaloid end product tia pathway demonstr sa spray posit impact transcript alkaloid synthesi addit abund transcript factor famili includ bhlh ch ch myb myb relat ap erf nac bzip wrki suggest role varieti transcript famili respons sa stimuli di nucleotid tri nucleotid ssrs preval ssr marker microsatellit analys make ssr marker respect total ssrs discov
D030008;D046948
T123;T121;T002;T109
36,280,676
signal strength sting activ determin cytokin plastic cell death human monocyt cyclic gmp amp synthas cgas stimul interferon gene sting pathway cytosol sensor microbi host deriv dna play key role innat immun activ sting cyclic dinucleotid cdn ligand human monocyt induc type interferon respons product pro inflammatori cytokin associ induct massiv cell death studi evalu effect signal strength sting activ cytokin plastic human monocyt cdn c gamp non cdn diabzi msa sting ligand rang ec concentr c gamp nm diabzi msa induc ifn ip larg amount il tnf il il interest lps induc product il il abolish presenc diabzi msa wherea il tnf inhibit surpris observ tenfold lower msa ie fold lower diabzi ie nm concentr strong stimul secret anti inflammatori il il littl il tnf induct il associ regul prdm blimp cytokin secret stimul higher concentr accompani apoptosi shown cleavag caspas parp low concentr trigger overt cell death yet induc cleavag gasdermin result reveal previous unrecogn plastic human monocyt signal strength depend product pro versus anti inflammatori cytokin upon sting activ
D016207;D007370
T129;T121;T116
36,280,674
enhanc gasdermin induc tumor pyroptosi prevent escrt depend cell membran repair augment antitumor immun respons pore form gasdermin protein induc pyroptosi tumor cell promot anti tumor immun respons releas pro inflammatori cytokin immunogen substanc cell ruptur howev endosom sort complex requir transport escrt iii mediat cell membran repair signific diminish tumor cell pyroptosi repair subsequ remov gasdermin pore show block calcium influx trigger escrt iii depend membran repair biodegrad nanoparticl mediat sustain releas calcium chelat ei np strong enhanc intracellular deliv gsdmd induc tumor pyroptosi via bacteria base deliveri system vnp gd inject hydrogel lyophil hydrogel base cell patch develop peritumor administr treat primari metastat tumor implant treat inoper tumor respect hydrogel function local therapeut reservoir sustain releas vnp gd effect trigger tumor pyroptosi ei np prevent escrt iii induc plasma membran repair boost pyroptosi effect work synergist augment anti tumor immun respons
D000069292;D056827
T123;T116;T043
36,280,670
univers glycoenzym biosynthesi pipelin enabl effici cell free remodel glycan abil reconstitut natur glycosyl pathway prototyp entir new one scratch hamper limit avail function glycoenzym mani membran protein fail express heterolog host describ strategi topolog convert membran bound glycosyltransferas gts water solubl biocatalyst express high level cytoplasm live cell retent biolog activ demonstr univers approach facil product difficult express gts predomin human origin across sever common use express platform use subset water solubl enzym perform structur remodel free protein link glycan includ found monoclon antibodi therapeut trastuzumab overal strategi ration redesign gts provid effect versatil biosynthet rout larg quantiti divers enzymat activ gts find use structur function studi well biochem biomed applic involv complex glycomolecul
D016695;D011134
T121;T126;T116;T109
36,280,669
comparison copd primari care england scotland wale northern ireland current nation asthma copd audit programm nacap undertak audit copd primari care wale due near complet data coverag aim determin qualiti copd primari care uk nation compar wale found english scottish northern irish practic signific wors welsh practic record code lung function paramet use copd diagnosi or respect refer appropri patient pulmonari rehabilit or respect complet nation audit primari care wale may led improv care least improv record care wale occur elsewher uk highlight potenti import audit improv care qualiti accur record care
D011320;D029424
T058;T047
36,280,667
function bidirect sensit otolith organ establish transcript factor emx otolith organ inner ear innerv two parallel affer project brainstem cerebellum innerv propos segreg across line polar revers lpr within otolith organ divid organ two region hair cell hc opposit stereociliari orient relationship function signific anatom featur known show region express emx otolith organ establish lpr mediat neuron segreg across lpr constitut bidirect sensit function condit knockout cko emx hcs lack lpr tmie cko mechanotransduct abolish select hcs within emx express domain also lack bidirect sensit analys mutant indic lpr specif requir mice swim comfort travers balanc beam effici lpr requir mice stay rotat rod
D040542;D010037;D014157;D018398
T123;T023;T116;T044
36,280,666
microgli debri clear astrocyt via cb facilit phagocytosi degrad via rubicon depend noncanon autophagi mice microglia import immun cell central nervous system cns undergo turnov throughout lifespan microgli debri remov time manner accumul debri may influenc cns function clearanc microgli debri crucial cns homeostasi howev under mechan remain obscur investig dead microglia remov find although microglia phagocytos microgli debri vitro territori depend competit hinder microglia microgli debri engulf vivo contrast microgli debri main phagocytos astrocyt brain facilit cb opson engulf microgli fragment degrad astrocyt via rubicon depend lc associ phagocytosi lap form noncanon autophagi interfer cb mediat engulf subsequ lap disrupt remov degrad microgli debri respect togeth elucid cellular molecular mechan microgli debri remov mice extend knowledg mainten cns homeostasi
D017628;D001253
T025
36,280,663
dynam regul kif phosphoryl acetyl promot focal adhes disassembl pancreat cancer pancreat cancer pc prone distant metastasi earli stage attribut strong migrat abil tumor cell focal adhes turnov essenti cancer cell metastasi integrin recycl process key activ pathway focal adhes depolymer identifi key motor protein involv integrin recycl screen kinesin protein involv integrin recycl use kinesin famili sirna librari identifi kinesin famili kif key regul kif upregul metastasi pc tissu promot pc cell migrat invas identifi kif key compon mediat integrin fak signal acceler fa disassembl fak depend manner kif recruit pik c promot integrin fak signal fa disassembl raba depend manner c termin tail kif requir pik c interact raba activ addit also found sirt mediat acetyl kif essenti kif phosphoryl key activ event motor protein function togeth find indic kif interact pik c promot fa turnov pc cell control endosom recycl integrin sirt acetyl modif depend manner eventu promot focal adhes turnov distant metastasi pc
D022001;D010190
T026;T191
36,280,649
exopolysaccharid lactobacillus plantarum reduc cadmium uptak mitig cadmium toxic rice seedl exopolysaccharid epss use effect exogen substanc allevi toxic effect cadmium cd rice crop thus improv plant growth characterist stress condit reduc accumul cd grain under mechan still unclear present work effect epss lactobacillus plantarum effici cd absorpt distribut rice seedl cd stress investig result reveal growth rice seedl sever inhibit exposur cd result decreas plant height leaf length biomass inhibit phenomenon allevi addit epss l plantarum lpc under mechan might epss could facilit accumul effici cd rice root reduc transport rate cd root leav therefor decreas cd content leav research show cd content cell wall fraction rice seedl root increas addit epss proport cd cell organell cell solubl compon reduc applic epss promot proport pectat protein integr cd rice root content water solubl cd toxic plant decreas continu root leav studi clear confirm posit effect epss allevi cd toxic decreas cd transloc rice ground part furthermor subcellular distribut chemic form cd differ rice seedl part also affect addit epss might import potenti mechan epss respect allevi cd toxic rice find provid foundat applic exogen substanc improv growth perform crop heavi metal stress
D012275;D048191
T168;T007;T002
36,280,644
occup cancer urinari tract incid report behavior administr procedur tumor urinari tract among common type occup cancer signific proport may occup etiolog suspicion occup genesi subject mandatori report howev epidemiolog analys show number report receiv accid insur compani employ liabil insur associ signific lower expect final econom administr effort survey patient occup histori hinder adequ report routin systemat use structur questionnair part clinic routin hospit signific improv detect justifi suspect case theoret expect valu achiev sinc addit improv medic care adequ compens recognit occup diseas diseas relat care subject extra budgetari remuner germani uv go
D009784;D014571
T047;T191
36,280,642
halt random open label phase ii studi crofelem prevent chemotherapi induc diarrhea patient posit breast cancer receiv trastuzumab pertuzumab taxan assess whether crofelem would prevent chemotherapi induc diarrhea cid diarrhea patient posit stage breast cancer receiv trastuzumab h pertuzumab p taxan docetaxel paclitaxel withwithout carboplatin c alway combin docetaxel rather paclitaxel
D001943;D000970
T121;T191;T109
36,280,622
screen saikosaponin ssd produc endophyt fungi bupleurum scorzonerifolium willd saikosaponin ssd import bioactiv compound tradit chines medicin plant bupleurum scorzonerifolium willd exhibit mani effect anti tumor anti inflamm immunomodulatori sinc endophyt fungi possess natur capac produc similar secondari metabolit host plant promis altern sourc plant bioactiv natur product studi order search ssd produc strain endophyt isol b scorzonerifolium authent sequenc translat elong factor alpha gene tef sequenc analysi profil metabolit present crude exact carri ultra perform liquid chromatographi time flight mass spectrometri uplcq tof ms analysi result show two strain chs chs b scorzonerifolium could produc ssd uplcq tof ms analysi amount ssd produc strain chs chs gml respect chs chs show close phylogenet relationship fusarium oxysporum fusarium acuminatum respect accord concern endophyt fungi capabl produc ssd b scorzonerifolium found clear intent isol identifi endophyt fungi produc import activ secondari metabolit studi strain produc compound larg scale ferment even genet studi provid feasibl conveni way product ssd
D029972;D010946;D001688
T123;T121;T002
36,280,614
melodi workshop effect spatial tempor variat dose deliveri key activ melodi organis annual european meet scientif result futur direct strategi relev research discuss annual meet previous organis sole auspic melodi sinc joint organis european platform refer european radiat protect week erpw addit erpw meet melodi organis financ annual workshop dedic specif topic output recommend meet publish review articl workshop focuss one cross cut topic effect spatial tempor variat dose deliveri diseas risk current issu reb includ five review articl workshop effect spatial tempor variat dose deliveri editori short summari content
D011835
T061
36,280,608
antifung antibiofilm activ bee venom load chitosan nanoparticl novel approach combat fungal human pathogen preval opportunist human fungal pathogen increas worldwid antimicrobi resist one greatest medic challeng world face therefor studi aim develop novel agent control fungal pathogen honeybe product honey royal jelli propoli bee bread bee venom screen unicellular fungal ucf pathogen cryptococcus neoforman kodamaea ohmeri candida albican bee venom exhibit inhibitori effect protein content crude bee venom separ use gel filtrat techniqu eight fraction visual sodium dodecyl sulfat polyacrylamid gel electrophoresi sds page confirm presenc five band molecular weight kda bee venom bv api mellifera load chitosan nanoparticl prepar ionotrop gelat method encapsul effici averag size zeta potenti surfac appear transmiss electron microscop tem evalu prepar nanoparticl minimum inhibitori concentr mic crude bv bv load chitosan nanoparticl bv cnps evalu offer mention ucf mic valu crude bv mic valu case bv cnps decreas mgml c neoforman k ohmeri c albican respect also result show bv cnps suppress biofilm format well yeast hyphal transit form examin ucf result reveal bv cnps promis natur compound fungal pathogen treatment
D048271;D001514;D011429;D053758;D003455
T121;T123;T116;T073;T109;T131;T004
36,280,569
util central venous arteri co differ predict advers outcom liver transplant test whether develop abnorm venous arteri co differ pco earli phase postop care liver transplant lt relat multi organ dysfunct outcom
D002245;D016031
T061;T123;T197
36,280,564
neutral respons elicit homolog heterolog prime booster vaccin ancestr sar cov b p c b variant heterolog covid vaccin strategi aros due interrupt vaccin program plus delay shortag vaccin suppli analys neutral respons ancestr sar cov b p c b variant elicit homolog heterolog protocol combin gam covid vac chadox ad ncorv bbibp corv mrna vaccin homolog mrna heterolog scheme non replic viral vectorinactiv virus base vaccin combin mrna induc signific broader greater neutral antibodi respons moreov serum particip vaccin combin chadox sad ncorv bbibp corvnon replic viral vector base vaccin show higher equival neutral respons compar homolog protocol point good altern platform bbibp corv use second dose exhibit signific lower neutral respons compar protocol demonstr recommend second dose inform provid herein valuabl redesign vaccin strategi especi low incom countri still struggl low percentag immun popul vaccin suppli shortag
D000086382;D014765
T129;T047;T121;T067
36,280,558
impact rotavirus vaccin seizur hospit children systemat review previous studi found conflict result effect rotavirus rv vaccin seizur hospit children younger year old
D012400;D012401;D022243
T129;T121;T116;T005;T047
36,280,557
introduct text analyt educ educ often find possess larg amount text base materi student reflect narrat feedback assign materi provid critic insight topic interest also requir substanti amount time read interpret use purpos articl describ provid recommend text analyt
D057225;D004512
T065;T066
36,280,556
develop pharmacist compet saudi arabia propos nation compet framework support initi educ profession develop current acceler chang pharmacist role saudi arabia evid base development tool requir guid initi pharmaci educ defin compet earli career foundat level pharmacist progress studi aim develop profess wide compet framework foundat level pharmacist saudi arabia use intern pharmaceut feder fip global compet framework gbcf sourc framework
D010595;D004512
T065;T097
36,280,422
treatment acut unstabl proxim clavicular fractur hook plate sternoclavicular joint investig clinic effect sternoclavicular hook plate treat acut proxim clavicl fractur
D013247;D050723
T037;T030
36,280,421
height control shoulder hemiarthroplasti treatment proxim humerus fractur evalu method reduct use fragment greater tuberos determin clinic efficaci humer head replac prosthesi height proxim humerus fractur
D062785;D012784
T061;T037
36,280,420
arthroscop subscapulari augment treatment recurr disloc shoulder sever glenoid injuri investig method clinic effect treatment recurr shoulder disloc sever glenoid injuri arthroscop subscapulari augment
D012783;D007593;D012785;D004204
T030;T033;T023;T037;T047
36,280,419
finit element analysi arthroscop repair rotat cuff injuri differ transoss techniqu compar analyz biomechan differ differ transoss techniqu arthroscop repair rotat cuff injuri finit element analysi
D000070636
T033;T047;T037
36,280,418
studi diagnosi treatment lumbar disc herniat relat factor base dynam electromyographi analyz dynam electromyographi characterist relat factor lumbar back muscl activ patient lumbar disc herniat clarifi clinic signific dynam electromyographi diagnosi treatment patient lumbar disc herniat ldh
D007405
T047
36,280,417
combin use prefabr rib lock titanium plate ultrasound guid thorac paravertebr nerv blockad treatment multipl rib fractur among elder paper aim investig efficaci combin intern fixat use prefabr rib lock titanium plate ultrasound guid thorac paravertebr nerv blockad treat multipl rib fractur among elder
D012253;D009407
T061;T037
36,280,415
effect total arthroscop rotat cuff repair pain degre complic elder patient rotat cuff injuri within hour oper analyz clinic effect rotat cuff repair small incis rotat cuff repair total arthroscopi elder patient rotat cuff injuri
D000070636;D012785
T030;T033;T023;T037;T047
36,280,414
comparison multislic spiral ct mri diagnosi occult fractur knee joint meniscus ligament injuri investig diagnost valu multislic spiral ct msct mri occult fractur knee joint meniscus ligament injuri
D000070600;D005596;D007718;D000072600;D050723;D000070598
T023;T037
36,280,413
research progress lower limb align correct prosthesi posit angl unicompartment knee arthroplasti angl lower extrem forc line posit unicondylar prosthesi import factor affect long term surviv rate clinic outcom unicondylar replac prosthes insuffici lower limb align acceler wear prosthesi reduc surviv rate prosthesi excess lower limb align acceler progress contralater interventricular arthriti general believ lower limb forc line correct mild varus unicompartment knee arthroplasti howev scholar believ lower limb align effect function score prosthesi surviv rate unicompartment knee arthroplasti poor posit femor tibial prosthesi caus unexplain pain even prosthesi wear optim posit femor tibial prosthesi controversi general believ posterior tibial slope correct rang unicompartment knee arthroplasti scholar believ excess chang posterior tibial slope also affect balanc knee joint space knee joint rang motion studi show correct lower limb align mild varus still best lower limb align unicompartment knee arthroplasti best posit femor tibial prosthesi need confirm biomechan research correct tposterior tibial slope chang accord specif origin dissect angl patient oper
D019645;D007720;D020370
T061;T047;T074
36,280,412
kinesio tape combin electroacupunctur treatment bigliani typesubacromi imping syndrom investig clinic effect kinesio tape combin electroacupunctur treatment bigliani typesubacromi imping syndrom
D015671;D055052;D019534
T061;T047;T074
36,280,411
compar studi two elast fixat system singl segment lumbar disc herniat surgeri nucleus pulposus extract investig clinic applic two elast pedicl intern fixat system singl segment lumbar disc herniat fenestr
D007405;D013123;D000070614;D065289
T061;T047;T074;T023
36,280,410
clinic efficaci obliqu lumbar interbodi fusion combin unilater pedicl screw fixat via wilts approach treatment lumbar spinal stenosi evalu efficaci obliqu lumbar interbodi fusion combin unilater pedicl screw fixat via wilts approach treatment lumbar spinal stenosi
D013130;D065289;D013123;D017116
T061;T184;T020;T047;T074
36,280,409
case control studi endplat injuri lumbar spine two differ intervertebr fusion method summar compar endplat injuri occurr characterist clinic result transforamin intervertebr fusion combin pedicl screw fixat intermuscular approach obliqu later intervertebr fusion combin pedicl screw fixat treatment lumbar diseas
D013168;D013123;D016103;D010024
T061;T047;T037
36,280,408
clinic therapeut strategi refractur bone transport tibial bone defect explor clinic therapeut strategi refractur ilizarov bone transport techniqu treatment tibial bone defect
D013978;D018889
T061;T037
36,280,407
nrd assist ilizarov techniqu treatment infect bone soft tissu defect tibia investig clinic effect nrd assist ilizarov techniqu treatment infect bone soft tissu defect tibia
D018889;D013978
T061;T037
36,280,406
effect freshen techniqu dock site tibial bone transport manag studi effect freshen techniqu dock site tibial bone transport manag
D013978
T037
36,280,405
compar studi monolater circular fixat treatment infecti tibial nonunion compar treatment effect monolater circular extern fixat infecti tibial nonunion explor extern fixat structur better osteogen abil fewer complic
D013978
T037