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biomedical-topic-categorization-validation

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36,280,401
recommend make editori board divers inclus lack divers editori board hinder multifacet perspect field ecolog evolut conserv outlin ten key action editori board promot equiti divers inclus benefit journal attract wider readership enhanc divers among author overcom bias editori decis
D004463
T090
36,280,387
intracerebr hemorrhag relat clinic condit associ outcom among saudi non saudi patient univers hospit retrospect studi object intracerebr hemorrhag ich second common subtyp stroke object studi identifi differ saudi non saudi patient regard demograph clinic condit associ ich outcom
D002543;D020521
T047;T046
36,280,378
pelvic floor rehabilit prostatectomi updat preoper pelvic floor physiotherapi common prescrib limit postop stress urinari incontin radic prostatectomi done differ way object work achiev descript object exist techniqu
D014549;D014550
T047;T046
36,280,377
endoscop papillari abnorm urinari stone recognit epsr purpos articl present endoscop papillari abnorm stone recognit epsr state certifi nurs ide ibod work oper room
D007669;D052878;D014545
T047;T031
36,280,376
connect apa tool prostat cancer literatur review experi feedback adapt physic activ apa appear essenti support care oncolog help reduc differ side effect inher treatment diseas eg fatigu sarcopenia balanc problem could impact patient surviv howev systemat implement daili practic still patient reach recommend physic activ new tool digit connect one develop overcom barrier implement daili practic physic activ eg distanc home hospit aim articl provid overview differ connect tool offer exercis train monitor programm prostat cancer
D011471
T191
36,280,371
intent geriatr intern train go privat practic geriatr recent medic specialti franc privat practic possibl still minor special studi diploma creat provid possibl complet semest internship privat practic accord studi geriatr intern train would consid semest outsid hospit would consid set privat practic proport vari accord year nation qualifi test taken internship subdivis
D007396;D005853
T065;T090;T091;T097
36,280,370
physic activ elder major neurocognit disord decad literatur skeptic feasibl motor rehabilit impact well physic activ pa subject major neurocognit disord mncd includ alzheim diseas author report sever benefit pa physic cognit promot brain perfus neurogenesi synapt plastic well decreas oxid stress inflamm pa recommend case tncm
D000544
T047;T048
36,280,369
enrich garden concept innov geriatr societ expect underlin import offer nurs home rsident environ favor health qualiti life experiment studi conduct enrich environ shown interest perspect without howev transpos live environ older person enrich garden innov concept geriatr result translat research could provid encourag answer question improv live environ psycho geriatr institut
D011788;D005853
T078;T090;T091
36,280,368
place support care support care context breast cancer elder part standard oncogeriatr care nevertheless multidisciplinari reinforc differ transvers team support global approach essenti qualiti care life cours evalu basi manag result evalu approach sexual health novelti often insuffici consid elder patient suffer breast malign
D011787;D001943
T058;T191;T169
36,280,367
place radiotherapi radiat therapi rt key compon manag elder breast cancer patient howev level evid elder patient limit patient select includ comorbid geriatr assess advanc radiat plan deliveri improv target coverag reduc toxic expand treatment elig altern techniqu treatment later prone posit may reduc risk toxic shorter cycl hypofraction whole breast rt safe effect case partial breast irradi may option
D001943
T191
36,280,366
medic oncolog treatment although patient year age repres major breast cancer patient limit data safeti efficaci medic oncolog treatment popul indic base primarili expert agreement literatur review discuss known data safeti efficaci main medic treatment breast cancer chemotherapi cytokin depend kinas inhibitor agent target human epiderm growth factor receptor novel antibodi conjug immunotherapi
D001943
T191
36,280,365
epidemiolog diagnosi extens breast cancer common cancer women elder whose number increas constitut popul right mani co morbid suffer epidemiolog breast cancer particular elder women describ well diagnosi assess extens differ rest popul
D001943
T191
36,280,362
structur guid comput screen approach predict plant enzym metabolit interact plant molecular factori spent million year evolv enzym need synthes divers primari special metabolit despit wealth metabolit plant produc mani enzym respons generat molecul yet identifi enzym known substrat extent substrat promiscu small molecul regul remain unexplor mani comput method identifi metabol enzym focus gene base approach reli transcriptom metabolom compar genom new ai base tool accur protein structur predict protein base strategi screen librari small molecul high qualiti protein model facilit identif substrat product inhibitor virtual screen use structur base drug design pharmaceut industri decad easili translat investig plant metabol enzym present method rapid user friend open sourc virtual screen use arabidopsi thaliana ugtf curat librari special metabolit herbicid autodock vina exampl method may appli broad metabol enzym compound librari easili adapt compound rank base relat bind affin result bind mode evalu use molecular visual program like pymol comput approach result virtual screen need valid use vitro vivo activ bind inhibit assay virtual screen may aid identifi substrat enzym unknown function revisit substrat select identifi natur synthet inhibitor
D011506;D006540
T123;T116;T131
36,280,361
lc msms assay enzymat character methylthioalkylmal synthas mam involv glucosinol biosynthesi brassicacea bless special metabolit call glucosinol gsls along degrad product benefici agricultur human health date gsl structur identifi most deriv amino acid methionin biosynthesi methionin deriv aliphat gsls start side chain elong step involv recurs three step cyclic process incorpor new methylen group oxo acid form seri elong oxo acid methylthioalkylmal synthas mam catalyz first commit step side chain elong methionin deriv gsls substrat specif mam differ oxo acid determin whether reaction product given cycl enter addit round chain elong enter core gsls structur format multipl mam encod gene present brassicacea speci known play central role shape divers profil aliphat gsls recent establish high sensit lc msms base methodolog quantifi mam activ estim amount next intermedi pathway malat deriv overal chapter describ protocol express purif steadi state kinet analysi recombin mam protein
D005961;D008293
T109
36,280,360
crispr cas mediat genom engin cyanobacteria past decad sever cyanobacteri strain emerg excit model system unravel import biolog process like photosynthesi nitrogen fixat parallel novel strain develop platform product various valu ad product meet either goal synthet biolog tool develop priorit among mani tool crispr mediat genom edit tool distinct hold potenti revolution cyanobacteri research chapter review current understand exist emerg crispr base technolog potenti applic advanc genom edit cyanobacteri strain interest crispr base tool gain traction cyanobacteri research abil target polyploid genom organ generat fulli segreg mutant remark short time discuss nativ cyanobacteri crispr system promis hold use precis tool cyanobacteri genom edit elabor methodolog develop crispr base markerless mutant cyanobacteria well discuss strategi larg scale regul genom silenc crispri also highlight emerg crispr tool shown promis prokaryot eukaryot system yet adapt cyanobacteri research
D064113;D000458
T040;T007
36,280,359
detect protein persulfid plant dimedon switch method hydrogen sulfid h well known signal molecul anim plant endogen produc cell involv wide varieti biolog function plant h regul wide rang essenti aspect plant life includ plant respons numer stress physiolog process import abscis acid aba depend stomat movement photosynthesi autophagi best studi molecular mechan respons sulfid signal protein persulfid post translat modif cystein residu thiol group p sh transform persulfid group p ssh way persulfid emerg new type cellular redox mechan regul protein structur function interest modif increas exponenti howev identif develop detect method challeng nevertheless basi chemic differ thiol persulfid group differ method implement plant differ high throughput proteom analyz perform use tag switch method first step thiol persulfid block second step persulfid select label use specif nucleophil chapter outlin new method previous describ mammal appli detect persulfid plant base chemic premis consist chemoselect persulfid label dimedon base probe provid detail workflow method includ procedur determin persulfid level protein extract visual quantifi fluoresc gel one side label purif persulfid protein identif mass spectrometri
D006862
T131;T197;T130
36,280,358
identif mpk kinas interactom use turboid proxim label proteom arabidopsi thaliana turboid new effici proxim label system first develop live mammalian cell turboid modifi bacteri biotin ligas fuse bait protein modifi proxim interact protein biotin prey protein subsequ label biotin tag pull streptavidin coat bead identifi mass spectrometri base proteom turboid recent appli live plant cell provid promis result identif interact protein mitogen activ protein kinas mpk import plant growth develop defens howev molecular mechan under rang mpk function complet known use modern proteom togeth turboid proof concept studi profil mpk interactom uncov function mpk plant signal cascad
D017360;D029681
T116;T002
36,280,357
proteom phosphoproteom c cam transit common ice plant among post translat modif protein phosphoryl one common studi sinc plant sessil organ mani physiolog process surviv depend regul phosphoryl dephosphoryl understand extent plant proteom phosphoryl specif development stage andor certain environment condit essenti identifi molecular switch regul physiolog process respons phosphoproteom workflow propos literatur provid tool exclus analyz phosphoryl protein imper examin proteom phosphoproteom reveal true complex biolog process describ mass spectrometri base phosphoproteom workflow analyz total phosphoryl protein method includ phenol base protein extract well techniqu measur quantiti qualiti protein extract addit compar detail effici suitabl gel solut trypsin digest method metal oxid affin chromatographi techniqu rapid effici enrich phosphoryl peptid lc msms method analysi phosphoryl peptid describ final present discuss result generat appli workflow studi c cam transit common ice plant mesembryanthemum crystallinum overal workflow provid robust method identif phosphoprotein total protein broad appli mani organ sampl type result provid accur pictur molecular switch regul differ biolog process
D040901;D035723
T091;T002
36,280,356
soybean seed proteom method isol detect identif low abund protein salt solubl globulin glycinin globulin conglycinin globulin abund seed protein soybean seed togeth two group protein account total soybean seed protein proteom assess less abund soybean seed protein use general isol protocol challeng due overwhelm abund storag protein develop simpl fast inexpens method remov storag protein seed extract signific enhanc studi nonabund protein within seed develop two simpl method deplet abund seed protein result enrich low abund protein soybean seed provid detail procedur isol separ identif quantif low abund seed protein soybean
D013025;D005916
T168;T116;T123
36,280,355
modif g protein biochemistri effect plantenviron interact heterotrimer gtp bind protein compris g g g subunit key regul multitud signal pathway eukaryot plant g protein current focus intens research due involv modul mani agronom import trait seed yield organ size abscis acid aba depend signal stress respons plant defens respons symbiosi nitrogen use effici mechanist detail g protein biochemistri modul process plant remain larg unknown although core g protein compon activationdeactiv chemistri broad conserv throughout eukaryot evolut regul seem rewir plant meet specif need plant g protein may spontan activ andor regul phosphoryl depend chang activ lipid second messeng phospholipas may even nucleotid exchang independ regul regardless deviat establish norm biochem properti plant g protein key affect plant phenotyp respons detail character activ vitro planta pave way precis manipul protein futur agricultur need
D000040;D020962
T123;T121;T116;T109;T126
36,280,354
structur function engin plant polyketid synthas type iii polyketid synthas pkss catalyz sequenti condens acyl coa thioester generat varieti polyketid scaffold remark structur divers signific biolog activ enzym share similar thiolas fold use common catalyt triad polyketid chain elong cyclize reaction structur biochem analys type iii pkss reveal function divers high homolog enzym attribut subtl chang activ site volum architectur accumul knowledg detail catalyt versatil mechan provid platform enzym engin via structur guid approach generat unnatur novel polyketid chapter method identif biochem character structur guid engin polyketid synthas describ detail along brief overview structur function enzym
D048630;D061065
T121;T126;T116;T109
36,280,353
tag applic stabl isotop label lc ms identifi precursor special metabolit plant untarget liquid chromatographymass spectrometri lc ms contribut comprehens unbias pictur metabol space plant data use quantifi natur metabolit variat genom wide associ studi compar global metabol respons environment genet perturb identifi previous undescrib metabolit natur major limit untarget metabolom classif identif thousand metabolit featur detect singl analyt run isotop label improv inform valu dataset categor metabolit deriv specif upstream precursor andor known metabol pathway c label precursor fed either plant tissu downstream metabolit produc higher mz valu molecul pre exist pool generat mz peak pair specif identifi within ms data paper outlin method principl consid supplement untarget ms data isotop label includ choos appropri isotop label grow feed plant tissu maxim label uptak incorpor deriv optim lc ms method interpret result label data although focus annot amino acid deriv metabolit use lc ms anticip method general adapt precursor plant speci chromatograph approach
D055106;D053719
T063
36,280,352
use target metabolom elucid indol auxin network plant plant hormon auxin play import role throughout entir life span plant facilit adapt chang environ multipl metabol pathway intersect control level flux indol acet acid iaa primari auxin plant speci measur chang pathway repres import object understand core aspect auxin signal regul studi becom approach technolog encompass target metabolom monitor incorpor stabl isotop label precursor propos intermedi possibl trace pathway util character new biosynthet rout auxin chemic inhibitor target specif step entir pathway relat auxin synthesi aid techniqu describ method obtain stabl isotop label pathway intermedi necessari pathway analysi quantif compound describ use isotop dilut method employ either gas chromatographi high perform liquid chromatographi mass spectrometri techniqu sensit analysi iaa complet biosynthet pathway analysi seedl use multipl stabl isotop label precursor chemic inhibitor coupl high sensit liquid chromatographi mass spectrometri method describ allow rapid measur isotop flux biochem pool method prove use research studi aspect auxin metabol network vivo varieti plant tissu various environment condit
D010937;D007210
T125;T123;T116;T109
36,280,351
isopren measur assess plant hydrocarbon emiss methylerythritol pathway isopren abund non methan hydrocarbon emit atmospher target biotechnolog sourc biofuel chemic feedstock measur amount isopren rate product isopren import atmospher chemistri evalu biotechnolog process provid inform capac regul methyl erythritol phosphat pathway found plant bacteria chapter discuss techniqu strength weak method common use measur isopren mani sourc isopren measur includ emiss leav head space analysi reaction involv recombin enzym bacterialfung cultur similar varieti detect method includ sever mass spectromet method use examin rate label isopren carbon isotop use
D010420;D056804
T109
36,280,350
measur flux sulfat assimil use sulfat sulfur metabol provid number compound essenti plant surviv fit affect yield qualiti crop sulfur metabol dynam process respond number extern cue dynam rapid turnov steadi state level sulfur contain compound alway fulli reflect plant respons cue therefor measur flux sulfat assimil may give precis estim effect environment stimuli metabol disturb sulfur metabol flux determin feed plant sulfat label isotop tracer describ protocol use sulfat measur flux sulfat assimil arabidopsi protocol adapt plant speci growth condit requir special equip beyond standard high perform liquid chromatograph hope protocol support colleagu frequent use flux measur answer new biolog question plant sulfur metabol
D013431;D017360
T121;T196;T002;T197
36,280,349
programm chemic actuat control solubl membran bound enzymat catalysi enzym catalyz reaction start stop throttl regul ion concentr solut flow charg solut relat flow electron electr circuit use electrochemistri howev current electrochem method vari ionic concentr larg limit electrod surfac make impract exploit ionic concentr control variabl tradit enzym assay chapter present electrochem cell term programm chemic actuat pca use select electrochem redox reaction regul concentr ion control enzym catalyz reaction kinet pca polypyrrol polymer equilibr impart mg mn oh ion select work electrod duplex puls amperometri demonstr revers control ph depend kinet alkalin phosphatas solubl homodimer enzym spectrophotometr assay pcas also use extend electrochem control membran bound enzym complex rubber transferas modul mg mn concentr radiometr enzym assay pcas demonstr tunabl control rubber transferas activ rubber molecular weight without dislodg either elong rubber molecul irrevers inhibit rubber transferas complex chapter present method fabric oper pcas facilit insight role ion biochem pathway environment respons plant
D012408;D011108
T104;T122;T073;T109
36,280,348
biocatalyt system compar assess function associ monolignol cytochrom p monooxygenas redox partner lignin complex heterogen polym deriv oxid radic polymer three monolignol ie p coumaryl alcohol coniferyl alcohol sinapyl alcohol lignin monomer precursor structur differ methoxi group benzen ring phenylpropanoid monolignol biosynthet pathway endoplasm reticulum er resid cytochrom p monooxygenas cinnam hydroxylas coumaroyl ester hydroxylas ferul hydroxylas establish key structur characterist monolignol catalysi cytochrom p monooxygenas requir reduc power suppli er electron transfer chain compos cytochrom p oxidoreductas cpr cytochrom b reductas cbr andor cytochrom b protein cb cofactor nadph nadh nadph depend cpr serv typic electron donor p enzym case cbr cb cpr cb electron transfer system also transfer electron termin p enzym tremend studi focus discoveri character cytochrom p monooxygenas howev limit attent paid versatil role electron transfer compon p catalyt system due membran resid properti p enzym electron transfer compon challeng establish effect experiment system evalu function associ ps redox partner chapter describ yeast cell biocatalyt system relat experiment procedur compar assess function relationship monolignol biosynthet p enzym differ redox partner catalysi
D042966;D008031
T123;T126;T116;T109
36,280,347
plant metacaspas case studi microcryst structur determin analysi metacaspas high conserv plant play essenti role mediat program cell death biotic abiot stress respons damag induc innat immun ca signal induc plant damag lead activ metacaspas arabidopsi thaliana atmc subsequ process plant elicitor peptid trigger downstream immuno respons understand structur basi atmc activ ca previous determin crystal structur perform crystal ca treatment probe activ associ conform chang enabl structur determin crystal ca activ analysi use microcryst relat method essenti success approach describ detail method use determin atmc structur use singl wavelength isomorph replac anomal signal assembl microcryst also describ method crystal ca soak microcryst data collect data assembl analysi obtain activ structur atmc micro size crystal describ method may use studi plant metacaspas broad plant enzym structur determin crystal function character
D029681;D017360
T116;T002
36,280,344
bisulfit free singl base resolut detect epigenet dna modif methylcytosin methyltransferas direct label apobeca deamin sequenc dna methyl methylcytosin mc preval epigenet modif predomin found cg dinucleotid mammalian genom depth investig function mc heavili reli quantit measur mc singl base resolut genom propos methyltransferas direct label apobeca aa deamin sequenc mlad seq method singl base resolut quantit detect mc dna mlad seq mutant dna methyltransferas mmpei nk util select transfer carboxymethyl group posit cytosin cg dinucleotid form carboxymethylcytosin camc use carboxi adenosyl l methionin casam cofactor aa treatment camc resist deamin base pair guanin thus cytosin cg site read c sequenc contrari methyl group mc inhibit carboxymethylcytosin mmpei nk therefor readili deamin aa produc thymin pair adenin read sequenc differenti readout c mc mlad seq enabl singl base resolut map mc cg site dna develop mlad seq method observ hypermethyl promot region retino acid receptor rarb gene human nonsmal cell lung tumor tissu compar harsh reaction condit bisulfit sequenc could lead signific degrad dna whole procedur mlad seq carri mild condit avoid dna damag thus mlad seq suitabl scenario limit input dna avail taken togeth mlad seq offer valuabl tool bisulfit free singl base resolut quantit detect mc limit dna
D044503;D008780
T123;T126;T116;T114
36,280,341
advanc evalu treatment sever asthma part two provid care patient sever therapi resist asthma novel option treatment administr addit inhal corticosteroid time increas symptom strategi refer anti inflammatori rescu air prove effect reduc frequenc exacerb improv asthma relat qualiti life long act muscarin antagonist use combin long act beta agonist bronchodil addit bronchodil care patient sever asthma must also includ strategi help avoid sever life threaten asthma attack intens patient educ recommend surviv toolkit
D018927;D001249
T121;T047
36,280,340
advanc evalu treatment sever asthma part one mani patient asthma incomplet poor control asthma despit treatment inhal corticosteroid long act beta agonist bronchodil vulner burdensom symptom limit exercis capac asthma attack frighten potenti life threaten articl outlin systemat approach evalu attempt identifi remedi factor make asthma sever person asthma approach includ emphasi ensur correct diagnosi minim exposur stimuli worsen airway inflamm allevi modifi comorbid chronic rhinosinus gastroesophag reflux support regular medic adher effect techniqu administ inhal medic basic diagnost laboratori work recommend modifi amplifi accord individu patient need
D001249;D005764
T047
36,280,339
role long term noninvas ventil chronic stabl hypercapn chronic obstruct pulmonari diseas despit heterogen data role noninvas ventil niv sever stabl chronic obstruct pulmonari diseas chronic hypercapnia current evid support use niv select popul phenotyp center medicar medicaid servic reimburs criteria complex practic navig effici method initi niv therapi continu challeng patient optim requir referr medic center physician specif train pulmonari sleep medicin navig specif need use niv
D063087;D012131;D029424
T061;T047;T046
36,280,338
care serious ill patient sar cov late sar cov caus greatest global health crisi centuri impact aspect societi covid pandem evolv throughout multipl variant emerg contribut multipl surg case covid worldwid high effect vaccin becam avail although pandem continu tremend expans basic translat clinic knowledg sar cov covid sinc pandem onset treatment option rapid explor attempt repurpos preexist medic tandem develop evalu novel agent care serious ill patient examin
D000086402;D000086382
T005;T067;T047
36,280,337
test treat mycobacterium tuberculosi infect infect mycobacterium tuberculosi minor individu progress tuberculosi diseas tb risk higher among person well establish risk factor within first year infect test treat individu high risk progress maxim benefit tb prevent therapi avoid test low risk person limit potenti harm sever treatment option avail rifamycin base regimen offer best efficaci safeti balanc review present overview diagnosi treatment tb infect summar common clinic scenario
D014376;D012294
T047;T195;T109
36,280,336
surviv surviv sepsi campaign even well intent polici great potenti caus harm statement vivid illustr influenti yet controversi surviv sepsi campaign guidelin subsequ cms benchmark despit low qualiti evid tendenti industri tie rebuk infecti diseas societi america idsa benchmark continu eschew therapi driven clinician expertis individu patient need favor mandat arbitrari one size fit approach suspend clinic judgment promot indiscrimin use treatment potenti caus great harm
D012772;D018805;D003141
T047;T046
36,280,335
marijuana lung evolv understand human be use marijuana product centuri relat recent data show extens cannabinoid receptor particular brain help explain impact cannabinoid symptomsdiseas pain seizur major nervous system compon marijuana caus bronchiti moder bodi literatur suggest distal airwayparenchym lung diseas occur marijuana caus chronic obstruct pulmonari diseas probabl caus lung cancer distinct differ tobacco potenti cognit impair damag develop brain contextu import benefici use explor
D002188;D002186;D029424
T121;T167;T109;T047;T002
36,280,334
electron cigarett use misus harm electron cigarett e cigarett batteri power devic use heat aerosol liquid contain varieti substanc usual nicotin andor cannabinoid flavor glycerol propylen glycol base inhal e cigarett rapid evolv time true health effect e cigarett difficult studi remain larg unknown review effect e cigarett nicotin addict pulmonari diseas includ effect dual use switch combust cigarett e cigarett studi show e cigarett use increas risk nicotin depend combust tobacco use studi show associ e cigarett use pulmonari diseas studi suggest reduc harm e cigarett use compar smoke requir studi adult use e cigarett also smoke cigarett epidemiolog studi suggest combin e cigarett cigarett harm use either product alon
D000072137;D066300;D014029;D008171;D002186
T121;T073;T109;T055;T047;T048
36,280,333
initi pharmacolog treatment tobacco depend adult strong evid base use exist pharmacotherapi support tobacco cessat alon combin ideal concurr behavior intervent futur pharmacotherapi develop may assist refractori case incorpor current futur therapi longitudin chronic care model tobacco depend help divers rang patient achiev independ nicotin addict
D016540;D014029
T055;T048
36,280,332
hypersensit pneumon updat diagnost guid internist summari highlight updat definit terminolog classif system propos diagnosi hypersensit pneumon clinic present epidemiolog pathophysiolog review recent data radiograph histopatholog diagnost criteria present manner relev practic general medicin internist includ new guidelin recommend role adjunct test serum igg test bronchoalveolar lavag lymphocyt analysi pulmonari function test discuss context support diagnost confid hypersensit pneumon diagnosi final new diagnost algorithm synthes appli general intern medicin set
D000542
T047
36,280,331
lung cancer screen lung cancer screen low dose comput tomographi ldct reduc lung cancer death earli detect unit state prevent servic task forc recommend lung cancer screen ldct adult age year year least pack year smoke histori current smoke quit within past year implement lung cancer screen program complex high qualiti screen requir involv multidisciplinari team aim screen program find balanc mortal reduct avoid potenti harm relat fals posit find overdiagnosi invas procedur radiat exposur compon process high qualiti lung cancer screen program includ identif elig individu share decis make perform report ldct result manag screen detect lung nodul non nodul find smoke cessat ensur adher data collect qualiti improv
D055088;D008175
T060;T058;T191
36,280,330
dispar diseas burden treatment patient asthma chronic obstruct pulmonari diseas lung health reflect inequ societi asthma chronic obstruct pulmonari diseas lung condit common treat general clinic practic impos disproportion burden disadvantag patient numer factor mediat dispar lung health includ air pollut allergen exposur tobacco respiratori infect member racialethn minor low socioeconom status also inferior access high qualiti medic care compound dispar diseas burden physician work dispar practic wide rang polici reform achiev better air qualiti hous workplac safeti healthcar need achiev equiti lung health
D029424;D001249
T047
36,280,329
advanc surgic mechan manag chronic obstruct pulmonari diseas chronic obstruct pulmonari diseas copd third lead caus mortal unit state behind cardiovascular malign disord understand pathogenesi evolv led target mechan aspect diseas improv patient symptom qualiti life modern manag copd offer varieti mechan surgic treatment patient advanc diseas achiev benefit medic therapi alon treatment includ therapi aim lung volum reduct surgic bronchoscop techniqu techniqu establish proven benefit other still develop herein discuss techniqu aim improv clinician recognit patient may benefit intervent
D011788;D029424
T078;T047
36,280,328
cystic fibrosi high effect target therapeut impact sex racial dispar peopl cystic fibrosi cf live longer healthier live due part new therapi call cystic fibrosi transmembran conduct regul cftr modul howev dispar outcom still exist femal demonstr shorter life expect male oppos typic femal versus male life expect general unit state popul addit minor popul hispan ethnic african american less frequent elig new cftr modul mechan drive differ relat contribut cftr etiolog yet elucid
D019005;D003550
T123;T047;T116
36,280,326
respiratori tract microbiom pneumonia respiratori system like gut harbor vast varieti microorgan includ bacteria virus fungi advent next generat sequenc multi omic approach reveal divers function signific microorgan respiratori health identifi co evolut indigen respiratori microbiota human immun system howev immun respons usual generat homeostasi microbiota disturb respiratori microbiom identifi import shape respiratori immun gut microbiota oral microbiota also known pivot shape immun system respiratori tract influenc microbi dynam proteobacteria firmicut bacteroidet identifi predomin respiratori system streptococcus prevotella fusobacteria veillonella form major part potenti pathogen haemophilus neisseria also form small fraction healthi lung microbiom dysbiosi respiratori microbiom lead increas colon opportunist pathogen lead respiratori infect pneumonia chapter describ microbi divers respiratori system role respiratori microbiom respiratori infect like pneumonia chapter also discuss strategi prove effect prevent pneumonia
D064307;D011014;D012141
T032;T050;T028;T047;T001
36,280,325
gastrointestin microbiom context helicobact pylori infect stomach gastroduoden diseas infecti origin set sever gastroduoden diseas viz gastriti duoden ulcer gastric ulcer gastric adenocarcinoma gastric mucosa associ lymphoid tissu malt lymphoma appreci discoveri h pylori past two decad howev find mani laboratori suggest apart h pylori sever trillion microb popul human gastrointestin tract form microbiom respect nich like oral microbiom esophag microbiom gastric microbiom intestin microbiom may also particip maintain healthi state stomach duodenum dysbiosi lead alter relat abund key gastrointestin microb associ sever gastric diseas instanc increas abund genera like leptotrichia prevotella veillonella gastric microbiom decreas abund bifidobacterium intestin microbiom associ gastric cancer h pylori infect apart caus direct harm gastric epithelium virul protein like vacuol cytotoxin vaca cytotoxin associ gene caga also capabl trigger dysbiosi stomach intestin microbiom chapter discuss possibl role bacteria virus fungi archaea protozoa helminth human gastrointestin tract context h pylori infect stomach various gastroduoden diseas
D016481;D016480;D000069196;D013274
T047;T007;T191;T001
36,280,324
dysbiosi human microbiom infecti diseas sinc birth human bodi get colon various communiti symbiot commens microorgan persist till death individu human microbiom compris genom microorgan virus archaea eukaryot protozoa remark bacteria develop omic technolog gave way human microbiom project hmp aim explor collect microbi gene genom inhabit human bodi eubiosi ie healthi balanc composit microb contribut metabol function protect pathogen provid nutrient energi host wherea imbal divers microorgan term dysbiosi great influenc state health diseas chapter summar impact gut bacteria well human highlight protect role play human microbiota bacteri viral infect condit dysbiosi play role establish various infect metabol disord clostridioid difficil infect cfi inflammatori bowel diseas ibd cancer periodont obes describ detail treatment fecal transplant probiot prebiot phage therapi crisprca system target gut microbiota digest diseas also discuss
D000069196;D064307;D019936;D003141
T032;T007;T028;T047;T001
36,280,323
vagin microbiom dysbiosi preterm birth environment expos surfac human bodi harbor ecolog distinct microbi communiti mutualist benefici relationship depend bodi site microb may provid metabol function protect pathogen signal molecul modul host physiolog reduc diseas suscept recent understand vagin microbiom base cultur independ rrna gene sequenc indic lactobacillus domin microbi communiti healthi women play import role decreas suscept sever urogenit diseas includ bacteri fungal viral infect find shotgun sequenc vagin microbiom suggest microbi deriv lactic acid bacteriostat bactericid molecul lower vagin ph mediat protect regul bacteri speci domin compon vagin microbiom also play key role determin gestat period birth outcom reproduct age women presenc lactobacillus crispatus speci vagin milieu reduc risk preterm deliveri women asian ancestri deeper knowledg vagin microbiota role success develop newborn gut bacteria would also benefici microbiom mother chang throughout pregnanc link microbiom newborn chapter highlight updat inform new opportun human microbiom research focus assess risk preterm birth
D047928;D064307
T001;T032;T046;T028
36,280,322
human gut microbiota parkinson diseas bidirect communic gut brain come fascin recent year mani studi report onset gastrointestin issu appear long actual manifest parkinson diseas pd symptom disturb gut brain axi found link pd pd link neuropatholog chang enter nervous system signific alter gut microbiota suggest vital role gut microbiota pd pathogenesi studi also suggest aggreg synuclein one major protein associ pd neuropatholog might start gut move central nervous system cns vagus nerv olfactori bulb inflamm gut suggest associ pd initi progress flush healthi gut microbiota replac pathogen induc gut inflamm promot neuroinflamm cns therefor intrigu understand mechan gut brain communic associ develop pd review shed light pd patholog gut dysbiosi associ pd medic alter gene express pathway microbi metabolit pd
D000069196;D010300
T047;T007;T001
36,280,321
human microbiom cardiovascular diseas number microorgan co evolv host among bacteria predomin organ colon site human microbiota contribut various physiolog function includ digest degrad food compon harvest inaccess nutrient immun system regul mainten gut barrier function regul brain function behavior microb gut produc wealth metabolit exogen dietari substanc endogen metabol compound produc host resid microorgan microbi deriv metabolit major factor host microbiota cross talk influenc host cardiometabol health direct indirect depend structur function microbi communiti evid suggest perturb composit function gut microbiota refer gut dysbiosi associ develop sever diseas condit gastrointestin tract colorect cancer metabol diseas obes diabet immun disord eg asthma allergi depress anxieti cardiometabol diseas sever patholog condit gastrointestin tract may impair intestin barrier allow transloc bacteria metabolit remot organ heart may ultim associ system inflamm develop cvds chapter discuss various gut microbiota depend metabolit signific role cardiovascular diseas patholog process risk factor final discuss therapeut potenti gut metabolit heart axi novel target treatment cvd highlight current updat excit direct futur research
D002318;D000069196
T047;T007;T001
36,280,320
gut microbiom dysbiosi malnutrit malnutrit global health issu lead caus childhood morbid mortal year old malnutrit compris undernutrit stunt wast underweight overweight obes infanc child malnutrit substanti influenc number variabl insuffici nutrient earli birth intestin inflamm gastrointestin tract microbiota varieti environment factor identifi modul structur divers newborn gut microbiom long term health signific data demonstr function potenc composit divers microbiom differ differ type malnutrit diverg gut microbiom composit malnourish healthi children observ age young month focus variat gut microbiom may influenc adult obesityhealth status begin earli year life therapeut potenti support healthi microbiom malnourish children studi techniqu aid fight malnutrit goal chapter determin makeup gut microbiota obes undernourish children age year
D000069196;D044342
T047;T007;T001
36,280,319
gut microbiom dysbiosi inflammatori bowel diseas inflammatori bowel diseas ibd complex multi factori chronic relaps diseas digest tract dysbiosi autochthon intestin microbiota environment factor host genet implic diseas develop sever cours treatment outcom two clinic well defin form ibd crohn diseas cd ulcer coliti uc cd affect local immun respons entir gastrointestin tract wherea inflamm uc main restrict colon mucosa prolong progress inflamm due cd uc often lead colon cancer healthi individu enorm taxonom divers function potenc gut microbiota includ member bacteri fungal microbiota tune host immun keep gastric environ benefici protect howev expans pathobiont autochthon microb potenc pathogen dysbiot condit gastrointestin tract subsequ enrich inflammatori microbi product gastrointestin milieu attract differ immun cell activ aberr host immun respons lead excess product secret differ cytokin damag colon epitheli cell manifest chronic inflammatori digest diseas current chapter provid updat understand differ bacteri fungal pathobiont genom metabol signatur geo specif divers gut microb link ibd across globe molecular resolut improv understand ibd factor associ diseas boost therapeut develop diseas manag
D000069196;D015212
T047;T007;T001
36,280,318
diarrheal diseas gut microbiom diarrheal diseas remain great public health problem mani countri enter infect caus sever viral bacteri parasit speci affect host also alter gut microbiom host physiolog dictat intestin milieu decid composit rich gut microbiota form homeostat ecosystem numer function provid protect invad pathogen diarrheal infect patient affect gut microbi dysbiosi benefit pathogen pro inflammatori bacteria enhanc colon prolifer gut microb associ sever pathophysiolog mechan includ distort motil intestin barrier dysfunct malabsorpt immun disord system inflamm chang gut organ axi sever abiot factor childhood malnutrit negat influenc gut microbiota includ antibiot lead antibiot associ diarrhea persist infect dna sequenc bioinformat analys enhanc percept gut microbiota network metabol interdepend role health diseas howev precis function microbiota gut homeostasi well defin chapter recapitul impact gut microbiota diarrheal pathogen import immun system reshap gut microbiota help recoveri phase addit discuss impedi influenc beyond diarrhea particular nutrit status children
D000069196;D064307
T032;T007;T028;T001
36,280,317
gut microbiom dysbiosi neonat sepsi sepsi high heterogen life threaten organ dysfunct primarili caus dysregul immun respons counter bacteri viral fungal infect result haemodynam chang signific morbid mortal across age recent time becom one foremost caus morbid mortal among newborn global neonat particular preterm neonat due immatur immun system non canon microbi communiti acquisit gastrointestin tract bodi habitat advers affect compar elder immunocompromis condit neonat could acquir microbiota utero deliveri mother genit tract postnat contact hospit personnel immedi hospit environ birth factor may enhanc risk includ earli colon microbiota pathogen trigger dysbiosi gut microbiom accompani dysregul immun respons organ dysfunct potenti death sepsi link mortal could prevent time diagnosi select antibiot therapi support postnat care infect due antibiot resist bacteria sever restrict possibl therapeut option thus extend hospit stay comprehens analysi infect pathogen cognat host respons microbiota present would certain help formul appropri intervent
D000069196;D000071074;D018805
T047;T007;T001;T046
36,280,316
gut microbiom emerg antibiot resist bacteri pathogen human gastrointestin tract home complex dynam communiti microorgan known gut microbiota provid host import metabol signal immunomodulatori function commens pathogen member gut microbiom serv reservoir antimicrobi resist gene arg caus potenti health threat host transfer arg suscept microb environ antimicrobi resist becom major burden human health wide recogn global challeng divers abund arg gut microbiom variabl depend exposur healthcar associ antibiot usag antibiot veterinari agricultur migrat popul transfer frequenc arg horizont gene transfer hgt help mobil genet element mges like plasmid transposon phage much higher among bacteria live gi tract compar microbi ecosystem hgt gut bacteria facilit multipl gene transfer mechan includ transform conjug transduct vesicl fusion need hour implement strict polici limit indiscrimin antibiot usag need develop rapid diagnost test resist determin altern antibiot like vaccin probiot bacteriophag therapi highest prioriti research develop sector collect action sustain develop resist pathogen promot endogen gut microbi growth divers interdisciplinari research find key overcom current antimicrobi resist crisi
D000069196
T007;T001
36,280,313
psychiatr hospit search extra soul evoc mean patient suffer quest appeas refocus reflect mission psychiatr hospit around recept accompani remind us role carer psychiatri avail listen benevol mainten link caregiv patient atmospher trust essenti care qualiti accompani must forget
D006778;D011570
T097;T091;T073;T093
36,280,312
psychiatr nurs work psychiatr sector nurs built know rich multipl sector sinc specif disappear belong common cultur anoth concept care emerg respond general trend rather specif territori need today hope knowledg know built pass refer area exchang yet invent
D011568
T091
36,280,311
practic psychiatri tomorrow come within start nurs career choos work psychiatr sector matter audac curios opportun like choic two nurs end third year nurs train institut laxou manon casucci mlusin leh baroncini testifi retrain bring alreadi clear object vision futur profession psychiatri ting optimist spirit believ contagi cross interview
D011570
T091;T097
36,280,310
meet lever toward exercis nurs care psychiatri nurs train provid nurs train institut multidisciplinari teach team cours nurs student forg profession ident howev psychiatri field popular student social represent apprehens lack knowledg disciplin crisi sector go work choic especi sinc young nurs ill equip develop suffici good postur line expect health care team nevertheless chosen work psychiatri emphas notion encount determin factor profession orient encount base three stage encount oneself specif knowledg clinic
D013338;D011570
T091;T097
36,280,309
advanc practic nurs psychiatri mental health advanc practic nurs psychiatri mental health apn pmh graduat new profess shake code interprofession function care peopl suffer mental disord seem import shed light issu involv implement apn also present train role certain theoret inspir make apn pmh multicultur actor care
D057179;D011570;D001523
T091;T097;T048
36,280,307
profession commit work psychiatri practic care psychiatr servic whether outpati inpati appear ever person commit conceiv despit difficulti profess make new profession hesit join open talk crisi psychiatri profession leav profess howev mani observ caregiv manag give mean demand profess crossroad disciplin institut activ constant evolv shape much advent multipl theoret framework societ movement number peopl use disciplin also call mental health care constant increas time player struggl recruit profession howev patient becom user testifi qualiti caregiv
D011570
T091;T097
36,280,306
work psychiatri st centuri chronicl psychiatricid sever year psychiatri confront unpreced crisi say persist malais context psychiatri yoke neurosci focus symptom thus reduc psych brain new situat undermin valu nurs care order continu deal patient suffer serious mental patholog team precious necessari unavoid resourc must also take account advanc practic nurs profession recent becom establish healthcar landscap possibl work psychiatri today still possibl provid care other
D011570
T091;T097
36,280,303
nurs student disabl guid provid accommod number nurs student disabl enter nurs school continu rise along critic need nurs accord feder law accommod must implement classroom clinic area nurs student disabl faculti administr must protect civil right disabl address barrier student success establish accommod use adapt equip servic anim accommod nurs student disabl success provid safe effect care patient add divers inclus nurs profess
D013338;D006233
T101;T097
36,280,302
innov pedagog approach teach advanc forens nurs forens nurs specialti nurs uniqu knowledg skill found theoret framework identifi three pillar knowledg legal principl forens scienc forens nurs concept context content uniqu specialti care patient trauma background intersect legal system forens nurs educ subsequ certif today requir educ technolog transform learn take demonstr activ chang interact dynam opportun teach metacognit activ provid complex trauma inform care aftermath violenc forens nurs
D053604
T091
36,280,301
interprofession simul digit world teach collabor practic web base environ interprofession educ ipe difficult implement mani reason excel interprofession simul educ effect person ipe program pivot teleconferenc format conduct simul student repres nurs advanc practic nurs medicin respiratori therapi occup therapi physic therapi pharmaci medic dietet speech languag patholog social work academ year month care plan recreat aspect person activ web base environ creat role duti conduct simul dress rehears necessari success student particip rate simul high effect
D033183;D057179
T062;T091;T054
36,280,300
futur perspect nurs polici technolog educ practic articl address relationship government law regul privat sector polici nurs practic integr polici process nurs educ curricula discuss relationship potenti effect sustain equit polici chang prepar nurs readi assum leadership role nurs input select use evalu technolog educ practic polici frame within leadership role basic advanc nurs
D007857;D003479
T078;T065;T170;T054
36,280,299
nurs ethic educ think feel technolog health care ethic educ focus four principl approach although relev import dimens insuffici emot cultur spiritu relat aspect ethic must also address ethic case import ethic educ includ everyday ethic scenario messi emot situat occur regular nurs practic make microeth particular relev nurs art song film literatur provid stori allow explor everyday ethic technolog facilit promot ethic comport work need demonstr best
D004993;D004506
T078;T065
36,280,298
disast prepared keep nurs staff student readi human face increas threat life properti due increas disast disast occur littl warn last hour month current literatur reveal nurs prepar disast communiti continu readi requir engag staff nurs student disast plan develop review implement develop educ train program ongo easili access engag realist best skill compet acquisit technolog virtual simul show great potenti prepar health care profession incorpor disast prepared plan
D004190;D004189;D013338;D009740
T097;T064;T052;T067
36,280,297
teach strategi onlin nurs practition physic assess telehealth educ physic assess cours nurs typic includ didact educ compon physic skill laboratori hand practic skill instruct focus head toe assess bodi system includ inspect palpat percuss auscult compar learn outcom achiev onlin tradit classroom telehealth educ need includ physic assess instruct telehealth servic expand provid greater access health care articl provid strategi incorpor educ onlin physic assess cours nurs suggest onlin resourc effect telehealth integr clinic practic
D009722;D017216
T058;T097
36,280,296
framework technolog triangul feedback support learn nurs educ student partner co creation classroom cultur assess learn rather assess learn three essenti sourc feedback instructor feedback peer feedback self reflect contribut develop metacognit skill necessari nurs practic triangul feedback multipl sourc develop skill peer evalu profession account emot regul lifelong learn feedback process support creativ use learn technolog learn manag system survey tool videographi use institut equip student person devic social annot strategi applic audienc respons system
D002983;D013672
T090;T080
36,280,295
best practic facilit mentor experi nurs student color need increas divers profess nurs requir innov approach recruit retain graduat nurs divers racial popul mentorship proven effect retent success strategi nurs student articl describ best practic mentor nurs student color aim increas awar impact mentorship role increas divers within profess nurs role technolog play facilit flexibl effect mentorship program explor
D013338;D000071252
T065;T097
36,280,294
influenc technolog support qualiti safeti nurs educ despit unpreced obstacl creat covid pandem nurs profession develop practition nurs educ success har educ technolog dissemin extraordinari amount vital inform need provid care societi crisi agil adopt educ technolog allow rapid access dissemin inform carri institut unchart water pandem creat roadmap mass educ techniqu guid futur disast prepared crisi intervent also applic nurs educ arena
D000086382;D004506
T065;T047;T067
36,280,293
student respons system onlin nurs educ student respons system srss use onlin nurs cours promot student engag cours content classmat instructor overview challeng opportun srss onlin nurs educ describ exampl implement srs onlin synchron nurs cours provid recommend best practic use srss nurs educ summar
D020375;D004506;D013338
T065;T097
36,280,292
power presenc virtual teach practic environ articl examin concept telepres use video chat platform facilit famili nurs presenc hospit set ethic technic logist challeng use video chat platform bedsid address addit communiti inquiri model use explor human presenc facilit distanc access nurs educ special focus use technolog meet challeng presenc virtual nurs instruct
D004506;D020375
T065
36,280,291
address challeng develop deliveri evalu continu educ nurs continu educ essenti profession nurs meet challeng today dynam health care environ nurs profession develop practition need stay abreast latest method best practic develop deliveri evalu continu educ need compet base continu educ program base principl adult learn contribut cultur autonomi empower use educ technolog collabor among emerg clinic role facilit opportun profession nurs stay engag lifelong learn
D001291;D004509
T065;T041
36,280,290
go strategi enhanc resili self care use technolog creat healthi work cultur profession burnout signific occup hazard result lower job commit poor patient outcom reduc perform lower job satisfact frequent absente model exist provid guidanc address burnout improv resili well advanc evid base multidisciplinari solut improv patient care care caregiv cornerston increas resili well empathi gratitud develop resili health care includ wide array technolog method facilit well digit journal mood track medit app habit track lifestyl app wearabl technolog strategi deal stress compass fatigu
D055500;D000068376;D002055
T055;T048
36,280,287
music meter induc interbrain synchron interperson coordin music induc peopl coordin one anoth conduct two experi examin under mechan interbrain synchron ib induc interperson coordin peopl expos music beat meter experi brain signal frontal cortex record simultan two particip dyad use function near infrar spectroscopi fnir hyperscan tap finger aural feedback partner coordin task independ task without music meter result show enhanc ib left middl frontal cortex case coordin task music beat meter ib signific correl particip perform term coordin experi examin ib particip coordin behavior various metric context strong weak meter ie highlow loud acoust accent beat result show strong meter elicit higher ib middl frontal cortex weak meter find reveal music beat meter affect brain brain coupl action coordin peopl provid insight interbrain mechan under effect music cooper
D009146;D043183
T047;T170
36,280,258
neurofila light chain level predict clinic convers radiolog isol syndrom evalu predict valu serum neurofila light chain snfl csf nfl cnfl patient radiolog isol syndrom ris evid diseas activ eda clinic convers cc
D020274;D003711
T047;T046
36,280,256
manag psychiatr cognit complic parkinson diseas neuropsychiatr symptom npss affect disord psychosi behavior chang cognit impair common parkinson diseas pd howev npss remain recogn treat often lead advers outcom epidemiolog present risk factor neural substrat manag strategi incomplet understood psycholog psychosoci factor may contribut hallmark pd neuropathophysiolog chang plus associ exposur dopaminerg medic occurr symptom suggest neurobiolog basi mani npss rang psychotrop medic psychotherapeut techniqu stimul therapi non pharmacolog treatment studi use clinic benefici manag npss pd appropri manag npss critic comprehens pd care recogn present time throughout diseas cours incorpor differ therapeut strategi ie pharmacolog non pharmacolog util multidisciplinari approach
D010300;D011618;D060825
T047;T048
36,280,249
quest greater equiti nation cross section studi experi black canadian medic student black medic student consist underrepres canadian medic school data impact discrimin medic educ remain limit cross section studi aim investig experi black medic student black medic student associ canada bmsac
D013337;D063505
T054;T097
36,280,248
matern neonat outcom pregnanc type diabet first nation manitoban peopl popul base studi first nation peopl live canada experi high preval type diabet pregnanc studi aim describ matern neonat outcom first nation femal type diabet live manitoba canada
D003924;D011248
T047;T046
36,280,247
determin sar cov vaccin willing among peopl incarcer canadian feder prison cross section studi maxim uptak sar cov vaccin among peopl prison essenti mitig futur outbreak aim determin factor associ willing receiv sar cov vaccin vaccin avail
D007252;D007251;D000086382;D011329
T129;T121;T098;T067;T109;T047
36,280,245
nt job help explor respons medic school across canada address anti black racism protest polic brutal anti black racism catalyz murder georg floyd black racial peopl spring address anti black racism histor minim institut prioriti across canadian medic school mani swift releas statement broad condemn racism given littl document institut respond action sought explor black medic student senior faculti perspect canadian medic school effort address anti black racism
D063505;D013337
T097;T054
36,280,243
factor contribut mental health black youth black peopl grow popul canada limit data avail factor contribut mental health black youth canada sought explor factor contribut mental health black youth alberta canada
D008603;D063505
T054;T041
36,280,233
global matrix physic activ report card grade children adolesc result analys countri global matrix physic activ pa children adolesc develop achiev comprehens understand global variat children adolesc pa relat measur key sourc influenc object articl summar find global matrix report card compar indic across countri explor trend relat human develop index geo cultur region
D015444;D000086382
T061;T056;T067;T047
36,280,232
promot physic activ among children adolesc disabl translat polici practic intern physic inact among children adolesc disabl cawd global public health issu polici effort promot physic activ pa among cawd increas studi summar intern polici trend promot pa among cawd behavior polici insight specif cawd countryregion indic activ healthi kid global allianc matrix physic activ children adolesc determin polici translat practic
D015444;D006233
T061;T056;T101
36,280,231
activ healthi kid global allianc global matrix resourc physic activ research brief report provid overview activ healthi kid global allianc ahkga introduct global matrix explan valu opportun ahkga effort asset provid physic activ research polici practic advocaci communiti outlin seri paper relat global matrix issu journal physic activ health invit futur involv
D015444;D006291
T061;T056;T089
36,280,230
associ physic activ indic human develop index nation level inform global matrix physic activ report card children adolesc aim studi explor associ key indic global matrix project human develop index hdi nation level accord sex age area resid abil level
D015444;D013177
T061;T056
36,280,229
recent secular trend child adolesc physic activ sedentari behavior intern analys activ healthi kid global allianc global matric examin recent global secular trend indic child adolesc physic activ sedentari behavior overal physic activ organ sport physic activ activ play activ transport sedentari behavior influenc famili peer school communiti environ govern
D057185;D013177
T033;T056;T079
36,280,228
econom freedom climat culpabl physic activ indic among children adolesc report card grade global matrix macrolevel factor econom climat factor associ physic activ indic studi explor pattern relationship econom freedom climat culpabl report card grade physic activ relat indic among countriesjurisdict particip global matrix
D015444;D058028
T061;T056;T170
36,280,092
evalu viscer adipos index cardiovascular risk factor biomark postmenopaus women predict cardiovascular diseas year studi viscer adipos index vai report benefici predict cardiovascular diseas cvd metabol syndrom met howev long term studi analyz efficaci vai predict cvd risk limit relationship vai electrolyt unclear studi aim determin vai use predictor cvd provid earli diagnosi possibl futur cvd patient moreov impact biomark electrolyt vai therefor indirect relat cvd analyz
D002318;D024821
T047
36,280,091
wast syndrom associ factor hospit older peopl wast syndrom ws character clinic import unintent weight loss six month syndrom respons signific portion hospit throughout world import indic serious diseas especi individu year age older aim present studi investig ws associ factor hospit older peopl observ cross section studi develop univers hospit brazil male femal patient year age ws consid occurr unintent weight loss month six month three month data collect sociodemograph clinic lifestyl nutrit biochem characterist studi receiv approv local institut review board particip sign statement inform consent sampl compos older peopl mean age year preval ws ws associ follow clinic variabl conserv ckd p dysphagia p dementia p anorexia p fatigu p function depend measur use barthel index p medic caus malabsorpt p follow nutrit variabl bodi mass index p low calf circumfer p low muscl strength p low muscl mass p undernourish risk malnutrit evalu use mini nutrit assess follow biochem variabl high crp p hypoalbuminemia p anemia p preval ws high among hospit older peopl present sampl associ clinic biochem aspect well nutrit variabl analyz contrast lifestyl sociodemograph characterist associ wast syndrom
D044342;D019282
T047
36,280,027
ketamin use anesthesia induct increas perfus index mean arteri pressur induct random doubl blind placebo control trial abnorm peripher perfus postinduct hypotens associ postop advers outcom ketamin may stimul blood circul activ sympathet nervous system studi aim identifi whether ketamin may improv hemodynam profil relat salin
D015742
T121;T109
36,280,019
guggulsteron commiphora mukul potenti anti glioblastoma efficaci temozolomid vitro vivo via regul egfrpikakt signal nf b activ myrrh aromat oleo gum resin extract stem commiphora myrrha nee engl efficaci promot blood circul remov blood stasi myrrh main use treatment chronic diseas includ cancer guggulsteron major activ steroid extract myrrh found inhibit cancer cell growth glioblastoma common malign central nervous system prognosi remain poor main due chemotherapeut resist activ status egfrpikakt nf b signal glioblastoma contribut poor respons chemotherapi block signal antagonist sensit glioblastoma cell chemotherapi
D016328;D005909
T129;T191;T116
36,280,018
antifung annona muricata l soursop extract target cell envelop multi drug resist candida albican annona muricata l soursop tradit use treatment inflammatori diseas cancer infect caus fungi therapeut activ explor medicin use general associ phytoconstitu acetogenin alkaloid howev potenti antifung bioactiv well mechan action remain establish
D031041
T002
36,280,015
hedychium flavum flower essenti oil chemic composit anti inflammatori activ relat mechan vitro vivo hedychium flavum ornament edibl medicin plant extens cultiv sourc aromat essenti oil eo flower tradit chines medicin treat inflamm relat diseas like indigest diarrhea stomach pain particular h flavum flower eo use cosmet aromat stomach treat chronic gastriti china
D009822;D030521
T002;T109
36,279,991
microplast malaysian bottl water brand occurr potenti human exposur world health organ note grow need determin occurr microplast bottl water potenti risk human health thus present studi analyz microplast eight major bottl water brand avail malaysia estim potenti human exposur membran filtrat method follow visual polym identif util identifi microplast particl eight major bottl water brand microplast concentr bottl water sampl rang particlesl averag particlesl particl size rang domin account approxim bottl water brand fragment identifi microplast bottl water transpar color preval polyethylen terephthal pet polypropylen pp polym type found studi consist prior result microplast bottl water main deriv packag materi bottl cap estim dietari intak edi adult particlekgday edi children particlekgday although consumpt bottl water estim low edi valu potenti risk human health heed due presenc numer plastic addit residu monom particl potenti increas inflammatori reaction cytotox human bodi futur studi concentr understand microplast particl less associ factor bottl materi qualiti consumpt behaviour bottl water storag condit frequenc bottl open close understand effect microplast particl human toxicolog aspect
D060766;D014874
T131;T167
36,279,990
effect corn stover hydrochar anaerob digest perform associ wastewat hydrotherm carbon htc effect method enhanc fuel qualiti biomass subcrit water environ generat larg amount wastewat htcww convert anaerob digest ad methan studi howev toxic refractori substanc contain htcww tend caus oper instabl ad system solid product htc corn stover cs name cs hydrochar modifi koh immers ad ad reactor improv methanogen perform result show optimum dosag modifi hydrochar mch gl cod remov rate increas methan yield increas mlg cod pore oxygen contain function group mch provid colon point microorgan also enhanc electron transfer effici among methanogen archaea addit increas alkalin mch due alkalin modif increas ph buffer capabl acceler consumpt acet acid butyr acid earli ad stage day propion acid late ad stage day allevi organ acid accumul reduc lag period day advers effect toxic refractori substanc htcww ad perform also decreas due adsorpt mch begin ad process latter adsorb substanc could degrad microorgan colon mch surfac find studi show ad feasibl method recov organ energi contain htcww associ hydrochar use effect promot ad htcww
D062065;D003313
T168;T083;T069;T002
36,279,984
opto extinct threat memori mice memori past experi guid futur behaviour spars ensembl neuron known engram thought store memori brain neuron involv particular engram engram neuron necessari subsequ memori express memori retriev thought initi extern sensori cue reactiv engram neuron howev condit environ dynam futur behaviour flexibl role engram mediat flexibl behaviour understood examin question use one type flexibl behaviour extinct threat respons initi neutral tone first pair avers footshock tone alon induc defens freez subsequ repeat tone present without footshock rodent longer freez tone tone cue thought reactiv engram induc memori retriev examin whether possibl induc extinct like behaviour effect optogenet reactiv later amygdala compon engram alon without tone exposur similar tone induc extinct mice show decreas freez optogenet stimul later amygdala engram extinct train session moreov opto extinguish mice show decreas freez tone subsequ test retriev extinct train context suggest opto extinct transfer actual sensori stimulus howev unlik tone extinct mice show renew tone induc freez test novel context opto extinguish mice continu show deficit tone induc freez extinct character new learn inhibit origin memori phenomenon origin memori unlearn find suggest opto extinct may silenc origin engram unlearn origin memori
D005239;D008568
T041
36,279,980
insight c c assimil pathway type methanotroph bacterium co product propanediol lactat methanotroph bacteria attract host mine metabol pathway c assimil produc valu ad product herein type methanotroph methylotuvimicrobium alcaliphilum z employ explor carbon flux methan methanol via emp pathway produc propanediol pdo product pdo methan found main restrict lower carbon flux toward emp pathway co util c substrat glycerol c could contribut enhanc pdo lactat co produc much higher amount pdo unexpect product probabl deriv lactaldehyd inher aldehyd dehydrogenas pdo product without increas accumul lactat observ via establish acetol base pathway propan util overexpress pmod first studi provid experiment insight oper metabol rout pdo lactat co product c c compound methanotroph
D019946;D019344
T121;T123;T109
36,279,979
remodel metabol high level resveratrol product yarrowia lipolytica resveratrol polyphenol numer applic food pharma cosmet lack precursor low titer main problem hinder industri scale resveratrol product base previous prescreen express combin fjtal pccl vvsts achiev best resveratrol titer improv mgl engin shikim acid pathway appli modular enzym assembl pccl vvsts enhanc p coumar acid suppli divert glycolyt flux toward erythros phosphat titer increas mgl follow two round multicopi integr resveratrol biosynthesi malonyl coa suppli respect titer reach gl yield glucos mgg use optimum fed batch strategi l bioreactor morpholog control research highest report de novo product resveratrol yarrowia lipolytica find lay solid foundat produc polyphenol
D025062
T004