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biomedical-topic-categorization-validation

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36,279,960
multi scale model lumen format via invers membran bleb mechan sprout angiogenesi process cancer one lead caus mortal morbid among peopl worldwid cancer appear solid tumor mani case angiogenesi growth blood vessel exist vasculatur one imper process tumor growth anoth vital phenomenon format function vasculatur network lumen format result recent studi indic import blood pressur mechan comput model studi process differ scale henc wide varieti model propos recent year research multi scale model develop angiogenesi process extracellular scale growth factor concentr calcul via reaction diffus equat cellular scale growth migrat adhes endotheli cell model pott cellular model intra cellular scale consid biochem signal boolean network model describ migrat divis apoptosi endotheli cell stochast model develop lumen format via invers membran bleb mechan cfd simul also use investig role pulsat blood pressur invers membran bleb mechan lumen format model show stochast behavior bleb expans lumen expans compar stochast model result cfd simul also show vital role pressur puls topolog bleb bleb retract
D042783;D001768
T033;T025
36,279,959
multi timescal analysi midbrain dopamin neuron fire activ midbrain dopamin da neuron exhibit spike burst pattern physiolog condit base data electrophysiolog record yu et al develop dimension mathemat model captur detail characterist da neuron fire activ use fit method simplifi origin model dimension model spike burst transit detect simpl robust mathemat condit physiolog condit balanc restor regen ion channel rest potenti geometr condit impos transcrit bifurc moreov combin singular theori singular perturb method captur geometri three timescal fire attractor univers unfold cusp singular particular planar descript correspond fire pattern generat correspond fire attractor analysi provid new idea understand fire activ da neuron specif mechan switch dynam regul among differ pattern
D004298;D008636
T123;T023;T121;T109
36,279,957
multifari explor synapt tag captur hypothesi synapt plastic develop integr mathemat model comput experi synapt tag captur stc hypothesi explain integr associ synapt activ also format learn memori synapt pathway involv synapt tag captur phenomenon call stc pathway stc hypothesi provid potenti explan neuron synapt process under synapt consolid memori sever mechan molecul propos explain process memori alloc synapt tag respect howev clear link stc hypothesi memori alloc still miss encod memori neural circuit main associ strong recurr connect group neuron explor mechan potenti synapt tag candid involv process memori alloc develop mathemat model singl dendrit spine base five essenti criteria synapt tag develop mathemat model attempt understand role potenti critic molecular network under stc essenti attribut synapt tag includ essenti memori molecul stc model identifi earlier studi crucial stc pathway camkii activ critic set initi tag howev coordin activ kinas biochem pathway necessari tag stabl pka modul nmdar mediat ca signal similar pka erk crosstalk essenti ca mediat protein synthesi l ltp theoret model explain quantit contribut tag protein synthesi l ltp synapt strength
D013569;D009473
T043;T042;T030
36,279,932
non genom uterorelax action corticosteroid hormon rat vitro vivo studi aim identifi short term effect glucocorticoid gc mineralocorticoid mc non pregnant late pregnant rat uterin contract estim tocolyt potenti
D015735;D014590
T121;T042;T109
36,279,894
dabigatran revers practic approach dabigatran direct oral anticoagul use prevent stroke system embol patient atrial fibril situat requir urgent revers anticoagul activ case sever bleed life threaten urgent emerg surgeri invas procedur signific bleed risk need thrombolysi patient ischem stroke sever measur taken includ use specif revers agent idarucizumab base guidelin use revers agent oral anticoagul clinic experi revers dabigatran practic guid present use clinic situat revers dabigatran anticoagul requir includ use idarucizumab adopt type guidelin contribut therapeut optim consequ greater revers effici better resourc manag
D001281;D000069604;D006470
T121;T047;T046;T109
36,279,893
role molecular allergen diagnosi cat pork syndrom unusu case report cat pork syndrom rare condit case report literatur syndrom justifi homolog serum albumin cat pork evid suggest primari sensit cat serum albumin fel occur follow allerg reaction ingest pork meat contain serum albumin sus due homolog mammalian serum albumin reaction meat also present report well document case report patient cat pork syndrom initi mild non specif manifest well cook pork overlook compon resolv diagnosi essenti establish diagnosi confirm involv fed sus less relev help defin avoid diet sinc sensit profil accord clinic manifest
D005512;D000080305;D000069466
T168;T046
36,279,892
treatment lymphorrhea associ amput stump lymphaticovenular anastomosi lower limb lymphorrhea condit consider impact qualiti life usual associ inguin lymph node dissect vascular procedur femor exposur case report describ patient underw knee amput two year later develop lymphorrhea stump prevent adapt prosthesi lymphoscintigraphi show delay lymphat progress failur conserv treatment underw lymphaticovenular anastomosi success outcom drainag cessat suggest lymphaticovenular anastomosi may effect treatment patient lymphorrhea amput stump although studi requir determin long term efficaci
D008209
T047;T046
36,279,891
cutan manifest pregnanc pregnanc period character complex signific skin chang major impact woman life cutan manifest associ period usual divid physiolog chang relat pregnanc pre exist dermatos modifi pregnanc pregnanc specif dermatos latter potenti associ signific fetal morbid diagnosi dermatos pregnanc challeng due variabl clinic present therefor complet detail clinic histori thorough physic examin essenti primari care clinician abl recogn entiti provid therapeut strategi well refer patient whenev risk mother fetus multidisciplinari team essenti evalu complex entiti includ dermatologist pediatrician obstetrician famili physician mother symptomat relief minim fetal risk achiev quick concurr
D011248;D012871
T047;T046
36,279,866
sexual transmit diseas std earli detect compet treatment sexual transmit diseas stds essenti maintain restor sexual health affect prevent transmiss context counsel sexual transmit infect sti particular import term prevent rapid diagnosi treatment sti rare germani syphili gonococc chlamydi infect even occur increas frequenc especi among msm risk popul msm sex worker peopl high preval region partner sti suffer offer sti screen sti present affect also activ screen stis furthermor partner also examin stis treat necessari syphili stis also occur complet unspecif symptom even asymptomat infect gonococci chlamydia mycoplasma hpv hbv hcv hpv lead serious complic late consequ sti hiv hbv syphili high effect post exposur prophylaxi pep avail case
D013587;D030361;D015658;D000072339;D012749;D002690
T047;T098
36,279,865
post covid matter definit preval post covid syndrom pcs yet conclus clarifi exist definit primarili reflect tempor aspect disregard function deficit well objectif symptom lead diagnost well therapeut ambigu pubm search systemat review deal impact sar cov infect under definit well tempor inclus criteria extract systemat review includ includ definit pcs individu studi analyz patient symptomatolog week thus accord definit pcs includ conclus clarif definit pcs necessari facilit diagnosi multimod treatment use scarc therapeut resourc accord
D000086382
T047;T067
36,279,864
use antifibrot drug interstiti lung diseas interstiti lung diseas ild heterogen group diseas often lead progress fibrosi lung correspond function impair nintedanib tyrosinkinas inhibitor angiokinas inhibitor well pirfenidon unfold effect among thing inhibit transform growth factor current approv antifibrot drug rapid progress idiopath pulmonari fibrosi ipf antifibrot drug nintedanib pirfenidon establish approv therapi sever year initi antifibrot therapi carri earli diagnosi multidisciplinari discuss mdd system scleroderma lung involv nintedanib use case relev fibrosi addit immunosuppress therapi recent nintedanib also becom new option treatment progress fibros ild pf ild describ cours various diseas entiti connect tissu diseas associ ild ctd ild fibros hypersensit pneumon fibros cours non ipf idiopath interstiti pneumon non ipf iip correspond fibros relat worsen respiratori symptom deterior lung function paramet diseas progress ct although pirfenidon also show posit signal group patient select studi use pf ild yet recommend particular gastrointestin side effect occur therapi antifibrot drug requir long term close interdisciplinari connect patient
D054990;D017563
T047
36,279,863
diagnost interstiti lung diseas practic instruct focus rheumatolog system diseas interstiti lung diseas ild etiolog heterogen unknown known caus like rheumatolog system diseas differ therapeut prognost consequ consensus pulmonologist rheumatologist radiologist pathologist develop practic instruct ild diagnosi rheumatolog system diseas particular ild present earli stage rheumat system diseas ild diagnosi base clinic assess result includ detail medic histori physic examin focus laboratori test radiolog high resolut comput tomographi lung function histopatholog also differenti cardiac infect associ lung diseas ild diagnosi made multidisciplinari discuss lead therapeut prognost consequ occurr acut exacerb especi critic often caus ild progress associ consider mortal
D017563;D012216;D003095;D001172
T047
36,279,861
generalist palliat care hospit first wave covid pandem research network german univers palliat care center pallpan part network univers medicin num recommend action develop regard care provid serious ill die patient pandem purpos experi need hospit staff work close patient outsid special palliat care unit first wave covid pandem also examin
D010166;D000086382
T061;T047;T067
36,279,860
univers dynam ridg filter pencil beam scan particl therapi novel concept ultra fast treatment deliveri objectivein pencil beam scan particl therapi short treatment deliveri time paramount effici treatment move target motion mitig techniqu breath hold rescan gate energi spot posit chang time limit factor reduc treatment time studi design univers dynam energi modul ridg filter rf broaden bragg peak reduc number energi spot requir cover target volum thus lower treatment timeapproach rf unit compris two ident rfs place isocent rfs move relat chang bragg peak characterist dynam simul differ bragg peak shape rf mont carlo simul code topa valid experiment deliv singl field plan gyfract differ geometr target water measur dose deliveri time use rf compar clinic settingsmain resultsalign rfs differ posit produc differ broaden bragg peak achiev maximum broaden cm rf reduc number energi field dose deliveri time geometr target investig without compromis dose distribut transvers distal fall offsignific novel univers dynam rf allow adapt bragg peak broaden spot andor energi layer base requir dose shape target volum signific reduc number energi layer spot cover target volum thus treatment time rf design ideal ultra fast treatment deliveri within singl breath hold effici deliveri motion mitig techniqu small anim irradi ultra high dose rate flash
D061766
T061
36,279,846
advanc applic capillari electromigr method analysi therapeut diagnost recombin protein review review provid comprehens overview methodolog advanc applic ce analysi character recombin therapeut diagnost protein past two decad first part review discuss various aspect biotechnolog protein product relat effect final product cover upstream process eg select transfect host cell scale cell cultur cultiv condit well downstream process discuss futur trend biotechnolog manufactur part essenti relat biotechnolog product analyt challeng requir order provid holist insight context influenc manufactur step qualiti final drug substanceproduct discuss term relat post translat modif target molecul major focus glycosyl pattern conform effect particular attent given host cell specif non human modif affect efficaci safeti recombin product endow propaedeut knowledg major part review discuss manifold contribut differ ce techniqu develop optim manufactur process evalu character final drug product role qualiti control differ ce techniqu cze capillari gel electrophoresi cge imag capillari isoelectr focus cief chipc ce western blot affin ce ace ce ms discuss includ brief introduct respect separ hyphen principl well applic analysi differ recombin biolog togeth recent strategi address analyt portfolio compris vast varieti recombin protein molecular mass kda mda recombin virus like particl pi rang antibodi explicit cover survey review complement compil valid aspect propos suitabl test order assur feasibl method industri pharmaceut need
D019075;D001688
T123;T121;T059
36,279,845
volumetr dri blood microsampl monitor imatinib mesyl therapi method develop clinic applic patient chronic myeloid leukemia chronic myeloid leukemia cml hematolog neoplasia character prolif diseas hematopoiet system imatinib mesyl im select tyrosin kinas inhibitor consid first line therapi cml indic adult pediatr patient present philadelphia chromosom ph howev patient treatment im may show differ respons due interindividu pharmacokinet variabl therapeut drug monitor routin perform identifi treatment respons profil adher treatment possibl drug interact thus support better treatment manag volumetr absorpt microsampl vam innov devic blood collect whose advantag includ possibl home collect patient physician offic assay fulli valid accord bioanalyt valid guidelin estim plasma concentr im statist differ group accord adher p median ng ml group level non adher versus ng ml group adher classifi moriski green questionnair studi includ patient cml treatment im patient answer socioeconom sociodemograph adher profil moriski green questionnair patient also receiv instruct home blood collect vam devic afterward sampl analyz lc msms mean age patient year ingest dose mgday major male im metabolit nim extract vam aqueous solut formic acid follow protein precipit acetonitril methodolog develop studi satisfactori determin im nim vam use hospit offic routin therapeut monitor patient cml
D053719;D015464
T063;T191
36,279,844
target protein identif andrographolid base isom approach target identif natur product one challeng issu standard applic tradit chines medicin wide recogn magnet nanoparticl mnps could function tool captur target protein activ molecul howev fals posit caus non specif adsorpt ignor report function mnps techniqu could enrich target protein andrographolid ag base isom approach design character mnps isom ag combin two could use ideal coupl provid feasibl method target protein enrich ag addit target protein identifi hplc msms moreov bioinformat analysi systemat comput dock perform search interact target protein ag six inflamm relat protein includ cd ikbkb pkn pkn ywhab ywhah prove anti inflammatori target ag result indic integr system could benefit target identif bioactiv natur product
D004224;D001688
T123;T121;T109
36,279,828
effect vitamin receptor gene polymorph risk chronic aggress periodont systemat review meta analysi chines popul explor whether vitamin receptor vdr gene polymorph associ risk chronic aggress periodont chines popul
D018167;D010520
T047;T116;T192
36,279,827
salivari metabolom burn mouth syndrom cross section studi lack systemat studi salivari metabolom profil burn mouth syndrom bms metabolom could help explor bms pathogenesi aim explor salivari metabolom profil patient bms use untarget metabolom techniqu
D002054
T047
36,279,826
chromatograph fingerprint base analysi extract green tea lemon balm linden ii simul chromatogram use global model medicin plant contain larg varieti chemic compound high variabl concentr qualiti control materi especi complex purpos regulatori institut accept chromatograph fingerprint valid tool perform analys order improv result separ condit maximis number detect peak chromatogram need work report extens simul strategi base global retent model previous develop select compound detect peak full chromatogram global model contain characterist paramet compon sampl paramet common compon describ combin effect column solvent approach begin detect measur automat posit peak chromatogram obtain prefer slowest gradient retent time detect compon fit find correspond solut paramet global model lead best agreement measur experiment valu process complet develop bandwidth model select compound use build global retent model base gradient data appli peak chromatogram use simul approach demonstr predict chromatograph fingerprint three medicin plant specif separ problem green tea lemon balm linden use sever multi linear gradient lead problemat predict
D031334;D010946
T002
36,279,825
current analysi strategi polychlorin naphthalen soil applic occurr distribut investig mini review new kind persist organ pollut polychlorin naphthalen pcns paid much attent owe environment health hazard sever countri announc move intensifi battl new pollut improv environment protect due matrix complex soil low level target pcns analysi requir ongo develop improv sensit accuraci effect extract techniqu allow separ interf substanc sensit analysi instrument possess low detect limit import part analyt procedur review focus dissemin latest advanc cover sampl pretreat instrument analysi method follow applic investig occurr homologu distribut pcns soil help reader quick understand pcns analysi method choos appropri one accord object laboratori condit may conduc supervis treatment new pollut
D012987;D004785
T131;T167
36,279,814
correl belief climat chang demograph ideolog belief system paper report two studi examin correl attitud climat chang acc first studi five hundr particip complet five questionnair intellig test well two relat measur acc use correl regress examin relationship acc demographi gender age educ ideolog polit religi belief intellig self belief belief world endors conspiraci theori one climat chang questionnair factor three factor label impact fatal person action consist find polit opinion strong relat climat chang belief conserv thinker deni individu could anyth second studi also particip ask one question concern serious took issu global warm examin relationship respons particip demographi ideolog self rate polit belief primarili relat global warm concern first studi result discuss term climat chang ideolog possibl chang belief limit like repres sampl singl item measur second studi acknowledg
D057231;D001290
T078;T055;T070;T041
36,279,789
exposur multipl trace element thyroid cancer risk chines adult case control studi incid thyroid cancer tc increas rapid last decad multipl trace element extern environ import effect thyroid function howev evid tc risk rare report total newli diagnos tc patient healthi control includ studi urinari element measur explain fix exposur effect tc risk condit logist regress use reflect multi element associ bayesian kernel machin regress bkmr appli show tendenc mix effect furthermor interact effect examin general linear model glm level lithium li cobalt co strontium sr zinc zn copper cu negat effect tc risk nevertheless lead pb arsenic chromid cr show posit effect bkmr glm model reflect effect fluctuat differ element slight interact effect li cr co zn pb studi requir confirm result futur
D014131;D013964
T123;T196;T121;T191
36,279,788
higher proport agricultur land use around resid associ higher urinari concentr ampa glyphos metabolit pesticid includ herbicid wide use agricultur sanitari reason concern rais various health effect littl research done extent agricultur land use residenti surround contribut intern exposur pesticid
D010575
T131
36,279,787
toxicolog exposur databas inventori review knowledg hazard exposur data chemic pollut essenti epidemiolog studi assess health risk prevent develop diseas access type inform clear need although numer databas dbs compil often extrem difficult find navig
D004785;D011084;D000393
T131;T109
36,279,750
vitro corros vivo behavior high strength mg zn mn alloy wire gastrointestin anastomosi nail applic ti alloy stapl retain human bodi long period excel corros resist thus requir revis surgeri remov studi biodegrad mg zn mn alloy stapl fabric use area reduct cold draw whose servic perform evalu vitro corros vivo test high strength mpa stapl main attribut format fine grain nanoparticl addit disloc moreov owe effect fine grain well high schmid factor prismat slip pyramid ca slip stapl also exhibit accept ductil vitro corros result indic stapl fractur occur immers h singl pbs solut addit gl bovin serum albumin bsa time requir maintain mechan integr stapl expand h main relat adsorpt chelat effect bsa mg matrix implant surgeri rabbit fulli recov normal oral intak mg ion generat degrad effect promot absorpt alimentari system therefor mg zn mn alloy stapl fabric studi exhibit desir effect excel clinic applic prospect
D008274;D000497
T123;T196;T197
36,279,749
suprachoroid inject polyzwitterion hydrogel treat glaucoma glaucoma primari caus irrevers blind worldwid current treatment primarili base drug usag surgic oper reduc intraocular pressur iop howev expens requir patient insist take medicin long time suprachoroid space scs space choroid sclera form part uveovortex pathway circul aqueous humor far still challeng realiz inject hydrogel scs long term durat work situ form polyzwitterion polycarboxybetain hydrogel design inject expand scs increas drainag aqueous humor eye via uveovortex pathway thus reduc iop least week commerci hyaluron acid hydrogel last week clinic ophthalmolog safeti assess examin show treatment polyzwitterion hydrogel well toler lead minim inflammatori reaction histopatholog assess demonstr scs expand inject hydrogel analysi ultrasound biomicroscopi reveal strong correl iop reduct scs expans short polyzwitterion hydrogel develop work prolong period iop reduct expand scs thus treat ocular hypertens glaucoma without resort drug regular surgeri
D005901;D020327;D000080324
T047;T074;T020;T030
36,279,748
develop characteris collagen gelatin base scaffold breast cancer research cultur present use tool cancer research fail replic tumor microenviron lack proper three dimension cell cellcel matrix interact often result exagger respons therapeut agent model aim overcom issu associ cultur research offer new frontier cancer research cell growth morpholog genet properti close match vivo cancer herein aim develop collagen base scaffold support attach prolifer breast cancer bc cell cultur model scaffold produc repeat basi use freez dri procedur construct high porous homogen pore size interconnect structur applic ethyl dimethylaminopropyl carbodiimid edac crosslink result scaffold elast moduli rang kpa mimick cancer breast tissu stiff furthermor incorpor gelatin scaffold enabl poros pore size mechan properti tailor result scaffold stiff valu accur replic stiff human bc extracellular matrix ecm kpa scaffold display high vitro stabil mass remain day cultur scaffold shown high biocompat capabl support attach infiltr prolifer mcf breast cancer bc cell day result confirm suitabl scaffold cultur model bc cell collagen base scaffold offer signific potenti explor aspect bc gene express profil pattern assess efficaci therapeut agent treat bc
D005780;D001943
T121;T191;T116
36,279,741
identif thienopyrimidin glycin select inhibitor h ntpdase h ntpdase essenti famili ectonucleotidas consist eight isozym various physiolog function undesir activ h ntpdase lead patholog condit cancer diabet inflamm thrombosi present studi seri thienopyrimidin synthes employ sequenti snar suzuki coupl synthes divers aryl substitut thienopyrimidin glycin deriv synthes compound constitut electron donat electron defici heteroaryl fluorin substitu thienopyrimidin screen h ntpdase determin effect activ h ntpdase compound j select block isozym h ntpdase compound e select inhibitor h ntpdase activ isozym h ntpdase select reduc inhibitor k wherea compound found activ inhibitor isozym h ntpdase molecular dock studi interpret interact potent inhibitor respect isozym import amino acid residu ie asp ser ser asp phe h ntpdase protein residu arg ala ala tye arg h ntpdase amino acid arg ser ala gli tyr h ntpdase wherea case h ntpdase residu val gln gli val involv interact inhibitor dock activ site isozym
D007527;D011743
T123;T126;T116;T114
36,279,740
biophys interact phenol acid yerba mate tea lipid membran yerba mate ilex paraguariensi tea well know sourc phenol antioxid compound caffeoyl deriv primari constitu account antioxid capac beverag propos interact polyphenol lipid bilay various cell type provid molecular rational hallmark antioxid anti inflammatori activ studi atomist molecular dynam md simul carri order outlin detail pictur molecular interact three caffeoyl acid deriv two differ lipid bilay show three phenol acid abl interact upper region lipid bilay confin action membran surfac moreov strength interact relay probabl metabolit proton insert bilay
D030019
T002
36,279,707
role insulin resist associ rest heart rate type diabet prospect studi elev rest heart rate rhr predictor incid type diabet td insulin resist thought play role associ howev extent insulin resist mediat associ unclear
D007333;D003924
T047;T046
36,279,706
trapezoid pile nuclear puls paramet identif method base deep learn transform model pile adjac nuclear puls unavoid actual detect process scholar tri appli deep learn techniqu identifi pile nuclear puls paramet howev tradit deep learn recurr neural network rnns suffer ineffici puls recognit poor recognit pile nuclear puls short interv adjac puls paper transform model attent mechan core recogn pile nuclear puls innov appli aim provid accur effici method pile nuclear puls recognit thus give better help spectrum correct high count rate
D000077321
T066
36,279,688
bcor variant associ x link recess partial epilepsi bcor gene encod corepressor bcl play import role fetal develop bcor mutat previous associ oculofaciocardiodent syndrom ofcd mcop omim bcor protein ubiquit express multipl area includ brain howev role bcor neurolog disord remain elus
D008850;D004828
T019;T047
36,279,655
interpret machin learn prognost system risk stratif oropharyng cancer optim manag oropharyng squamous cell carcinoma opscc includ surgic non surgic chemo radiotherapi treatment option combin approach carri risk specif treatment relat side effect hpv posit opscc report sensit chemo radiotherapi base treatment modal
D030361;D009959
T047;T191
36,279,654
general practition need wish clinic decis support system focus group studi share decis make sdm benefici patient healthcar profession often appli practic clinic decis support system cdss facilit sdm howev cdss accept rate rather low one context sdm general practition gp patient regard medic great valu older patient medic relat fall risk appli user center design optim tailor cdss need wish gps help overcom low cdss accept rate current studi aim learn gps need wish cdss focus diminish medic relat fall risk
D058005;D020000;D058006
T058;T170;T091;T097
36,279,642
transcriptom analysi show antifung mechan honokiol aspergillus flavus plant deriv substanc antifung agent receiv consider attent recent year reduc use chemic fungicid food preserv studi honokiol type phenol compound magnolia officinali found inhibit spore germin mycelia growth aspergillus flavus gml addit pathogen assay show honokiol potent antifung activ flavus corn flour suppress conidia product fluoresc stain transmiss electron microscopi biochem assay perform explor possibl inhibit mechan flavus result show destruct effect honokiol flavus appear relat increas plasma membran permeabl inhibit atpas activ mitochondri dysfunct accumul reactiv oxygen speci furthermor transcriptom analysi show honokiol treatment result differ express gene gen ontolog kyoto encyclopedia gene genom analysi reveal gene flavus relat spore develop integr cell wall membran oxid stress energi metabol signific downregul addit rna seq result valid quantit real time polymeras chain reaction find enhanc understand antifung activ honokiol under mechan action molecular level support honokiol potenti agent prevent contamin flavus
D001231;D017705
T004;T109
36,279,615
mixedmixotroph nitrogen remov effect sustain treatment wastewat treatment process microbi mechan biolog nitrogen remov bnr one import environment concern field wastewat treatment convent bnr process base heterotroph nitrogen remov henr suffer sever limit includ extern carbon sourc depend excess sludg product greenhous gas emiss mediat autotroph nitrogen remov aunr mixedmixotroph nitrogen remov mixnr offer viabl solut optim bnr process recent advanc characterist mixnr process guid sulfur driven autotroph denitrif sdad anammox summar review addit discuss function microorgan differ mixnr system shed light metabol mechan microbi interact signific mixnr carbon reduct bnr process also note knowledg gap futur research direct may facilit practic applic mixnr process highlight overal prospect mixnr process attract review provid guidanc futur implement mixnr process well deciph microbi metabol mechan
D062065;D009584
T123;T083;T196;T069
36,279,614
enhanc oxid organ contamin mn vii water studi promot chemic oxid permangan mno mn vii viabl technolog water treatment environment purif quick accumul past decad various method activ mn vii propos efficaci destruct wide rang emerg organ contamin demonstr articl aim present state art review develop mn vii activ method includ photoactiv electr activ addit redox mediat carbonac materi chemic agent particular focus potenti activ mechan critic influenc factor differ reaction mechan involv activ mn vii oxid process includ generat reactiv intermedi deriv mn vii eg mn iii mn v mn vi activ eg intermedi redox mediat ru catalyst reactiv oxygen speci ros eg oh well electron transfer organ mn vii via catalyst electron mediat except oh generat one co oxid uvmn vii process reactiv speci relat mild oxid select toward organ substrat high toler toward various water matric eg inorgan ion natur organ matter compar strong oxid radic speci therefor activ mn vii oxid process show good prospect effici remov target contamin natur complex environment matric howev disput domin reactiv speci generat process identif method may appropri caus serious confus mechanist understand effort still need fill knowledg gap also address applic challeng technolog
D017895;D018508
T197;T052;T057
36,279,613
remov behavior key driver antibiot resist gene two full scale leachat treatment plant leachat critic reservoir antibiot resist gene arg proper treatment close relat human health ecosystem safeti use high throughput qpcr explor remov behavior arg two full scale leachat treatment plant ltps biolog treatment membran filtrat process integr total arg mobil genet element mges detect aminoglycosid multidrug mlsb resist gene preval abund anaerob digest found import pretreat process leachat anoxicaerob tank membran bioreactor mbr act incub arg due signific prolifer effect arg integr membran filtrat uf nf ro excel arg remov absolut abund reduc order magnitud copiesml raw leachat copiesml effluent result also show leachat treatment process signific alter composit arg bacteri communiti procrust analysi network analysi reveal strong associ microb arg sever hub gene bacteri genera identifi structur equat model sem indic bacteri composit mges basic water properti key driver shape arg dynam raw leachat biolog system filtrat system respect notabl sever pathogen eg klebsiella vibrio aeromona close correl arg raw leachat may amplifi dissemin risk arg moreov insert sequenc biolog system would acceler horizont gene transfer arg short studi provid new insight mechan arg remov dissemin behavior industri scale ltps
D000900;D005798
T121;T195;T028
36,279,612
hypersalin produc water clarif dissolv air flotat sediment ultrashort resid time treatment reus produc water made difficult due hypersalin high concentr myriad dissolv suspend compon special technolog requir modular portabl short resid time lack exist inform process work produc water contain mgl total dissolv solid permian basin coagul aluminum chlorohydr ach floccul anion high molecular weight organ polym prior dissolv air flotat daf sediment reduc turbid ntu iron remov case total coagul floccul sedimentationflot resid time min two advantag daf sediment note daf requir half dosag pre hydrolyz ach coagul remov turbid iron even without organ polymer floccul ii daf even oper success without ach coagul ie use organ polymer floccul evidenc lower chemic dose need daf attain water qualiti oper goal recycl ratio demonstr outperform sediment generat clean brine relat reduc excess energi necessari air satur higher daf recycl ratio reduc turbid iron remov possibl due floc breakag colloid effect destabil doubl layer compress due high water salin charg neutral via adsorpt al polyc enmesh precipit amorph aluminum floccul via interparticl bridg anion organ polymer floccul creat larg compact floc facilit ultrashort flotationsediment time direct evid individu coagul floccul mechan obtain use electrophoret mobil measur thermogravimetr analysi x ray diffract x ray photoelectron spectroscopi fourier transform infrar spectroscopi optic microscopi comput imag video analysi scan electron microscopi energi dispers x ray spectroscopi
D018508
T052;T057
36,279,611
perceiv multipl stressor effect depend sampl size stressor gradient length multipl stressor continu deterior surfac water worldwid pose mani challeng conserv restor combin effect type multipl stressor rang singl stressor domin complex interact identifi preval combin effect type critic environment manag help prioritis key stressor mitig howev remain unclear whether observ singl combin stressor effect reflect true ecolog process unbias sampl size length stressor gradient therefor examin role sampl size stressor gradient length pair stressor respons case sampl river lake transit marin ecosystem around world case split overal stressor gradient two partial gradient lower upper investig associ chang singl combin stressor effect sampl size influenc identifi combin effect type stressor interact less like case fewer sampl split gradient case show chang combin effect type chang show loss stressor effect find suggest identifi combin effect type may often statist artefact rather repres ecolog process case observ chang stressor effect direct gradient split suggest unimod stressor effect general non linear respons pronounc organ higher trophic level conclud observ multipl stressor effect sole determin ecolog process also strong depend sampl design observ effect like chang sampl size andor gradient length modifi studi highlight need improv monitor programm suffici sampl size stressor gradient coverag find emphas import adapt manag stress reduct measur ecosystem degrad may chang multipl stressor effect relationship requir associ chang manag strategi
D017753;D045483
T070;T082
36,279,603
breastmilk pufa strong associ matern dietari intak anthropometr paramet breastmilk carotenoid long chain polyunsatur fatti acid pufa optim n n fatti acid ratio essenti proper neurodevelop infanc studi aim evalu associ breastmilk fatti acid intak matern dietari intak anthropometr breastmilk carotenoid level
D008895;D015525
T123;T121;T109;T031
36,279,588
raman spectroscopi open world learn set use objectospher approach raman spectroscopi combin machin learn techniqu hold great promis mani applic rapid sensit label free identif method approach perform well classifi spectra chemic speci encount train phase speci known neural network howev real world set clinic applic alway substanc whose spectra yet taken neural network encount new speci test phase number fals posit becom uncontrol limit use techniqu especi public safeti applic overcom barrier implement recent introduc entrop open set objectospher loss function demonstr efficaci effici approach compil databas hyperspectr raman imag chemic speci separ three class categor known class consist biolog relev speci compris amino acid ignor class irrelev speci compris bio relat chemic never seen class various chemic speci neural network seen show approach enabl network effect separ unknown speci preserv high accuraci known one reduc fals posit also perform better current gold standard machin learn techniqu open door use raman spectroscopi combin novel machin learn algorithm varieti practic applic avail implement freeli avail web https githubcombalytskyijaroslawramanopensetgit
D013059;D000069550
T070;T059;T066
36,279,584
dog ear wound closur minim conic deform found apic incis wound closur repres tissu redund common known dog ear amount tissu excess relat geometri incis surround skin elast tension closur experi tissu handl show dog ear settl resolv time case occur local tissu high skin elast dog ear small height tension line closur low dog ear fall categori troublesom surgeon patient alik poor impact aesthet outcom lead secondari revis procedur therefor present pertin review mechan behind dog ear format varieti surgic techniqu use minim correct format
D004954
T090
36,279,583
youngest composit full face transplant model vascular composit allograft younger popul field face transplant continu evolv complex defect address time increas outcom expect given uniqu long term experi field consent one youngest patient undergo full face transplant
D064595;D054445
T061;T023
36,279,582
integr plastic surgeri resid applic percept virtual interview interview cycl integr plastic surgeri applic first held virtual covid pandem detail largest studi integr plastic surgeri applic percept virtual interview cycl
D007396;D013518;D000086382;D013337
T091;T067;T097;T065;T047
36,279,581
divis fasciocutan pedicl flap time chang practic prospect random control trial studi carri evalu safeti earli divis pedicl flap identifi optimum day divis
D019651;D014946
T061;T046
36,279,580
dual innerv free gracili muscl transfer facial reanim children facial palsi may deleteri effect pediatr patient common reconstruct stage free gracili muscl transfer fgmt cross face nerv graft cfng requir prolong period time surgeri smile new techniqu use cfng motor nerv masset mnm dual power sourc singl stage surgeri describ adult examin experi techniqu children
D000071976;D005158;D019651;D020330
T061;T184;T023;T047
36,279,579
use busi model disciplin execut improv consist effici length stay microvascular autolog breast reconstruct autolog free tissu transfer common method breast reconstruct unit state involv mani care team incur larg cost institut consist effici perform procedur improv method call disciplin execut dx
D016462
T061
36,279,578
close incis negat pressur therapi prevent major abdomin donor site complic autolog breast reconstruct outcom autolog breast reconstruct continu improv refin microsurg techniqu howev donor site morbid remain concern close incis negat pressur therapi cinpt shown reduc wound complic limit evalu abdomin donor site shown promis result hypothes cinpt reduc abdomin donor site complic
D054843;D000072836;D016462
T061;T074;T037
36,279,577
breast reconstruct free flap failur platelet count matter microvascular free tissu transfer increas popular modal autolog tissu breast reconstruct howev flap failur remain omin risk continu plagu surgeon patient even set meticul surgic techniqu monitor venous arteri thrombos lead caus free flap failur purpos studi determin whether thrombocytosi associ breast free flap failur
D058752;D016462;D006490
T061;T121;T024
36,279,576
predictor infect benefit antibiot gunshot wound face gunshot wound gsws face high risk infect due extent tissu injuri often observ violat oral sinus caviti given ambigu data antibiot benefit gsw face purpos studi character antibiot usag infect detail risk factor associ higher infect rate gsw face
D014948
T037
36,279,575
clinic applic modifi local transposit flap parallelogram flap surgeri repair fingertip defect parallelogram flap perform transvers finger amput loss distal pulp nail bone studi aim compar clinic effect parallelogram flap antegrad homodigit island flap revers digit arteri island flap fingertip reconstruct
D005383;D019651
T061;T037
36,279,574
lower trapezius myocutan propel flap base dorsal scapular arteri pedicl lower trapezius myocutan flap general transfer recipi site subcutan tunnel portion flap buri tunnel need de epitheli thus consider amount normal skin sacrif redund tissu buri tunnel caus bulg deform believ transfer lower trapezius myocutan flap propel fashion avoid aforement issu
D064171;D019651;D017695;D064827;D061525
T061;T023;T024;T037
36,279,573
prepector breast reconstruct reduc opioid consumpt pain mastectomi head head comparison submuscular reconstruct acut pain mastectomi increas concurr breast reconstruct one postul advantag prepector breast reconstruct less postop pain howev comparison partial submuscular reconstruct made date examin postop pain experienc patient prepector subpector breast reconstruct mastectomi
D019928;D001943;D016462;D018427
T061;T191;T074
36,279,572
postop clinic radiolog analysi deviat nose anatom deform great alter nasal function larg correct septoplasti septorhinoplasti oper studi aim object measur result septoplasti surgeri deviat nose radiolog analysi compar result clinic evalu
D009667;D012225;D015508
T061;T047;T033;T020
36,279,571
master degre among academ plastic surgeon plastic surgeri resid trend plastic surgeri clinician pursu advanc degre strive becom stronger physician scientist object understand degre influenc career becom import hypothes master degre associ higher scholar activ research fund academ progress leadership appoint
D013518;D066231
T091;T097
36,279,566
fear covid relat factor affect mother breastfeed self efficaci pandem studi aim determin breastfeed self efficaci level mother pandem period compar accord various characterist examin relationship fear covid breastfeed self efficaci
D001942;D000086382
T067;T055;T040;T058;T047
36,279,565
prevent measur pressur injuri structur social represent nurs team analyz structur social represent prevent measur pressur injuri nurs team
D036301
T062
36,279,558
realiti inadequ patient care need global action framework organ donat transplant transplant therapi consid best often avail treatment thousand patient organ failur result communic noncommunic diseas number annual organ transplant insuffici worldwid need
D009927;D016377
T061;T073;T055;T033;T058
36,279,553
captur heterogen circul tumor cell colorect cancer patient immunomagnet anti nonspecif adsorpt platform circul tumor cell ctc repres differ phenotyp due epitheli mesenchym transit emt epitheli ctc e ctc mesenchym ctc ctc mix epitheli mesenchym ctc em ctc limit work systemat discuss associ ctc number especi proport e ctc ctc em ctc total ctc colorect cancer crc progress via simpl method high perform achiev goal paper present fabric novel anti nonspecif adsorpt immunomagnet platform call fe sio ptmao aptam obtain modifi polymer trimethylamin n oxid ptmao magnet fe sio link dual aptam epitheli cellular adhes molecul epcam cell surfac vimentin csv target differ ctc phenotyp result demonstr abund coat ptmao fe sio improv anti nonspecif adsorpt noncel adhes abil immunomagnet particl could captur heterogen ctc higher effici within min excel perform fe sio ptmao aptam allow us inspect correl number e ctc ctc em ctc proport total ctc clinic inform crc patient detail data innov clear reveal captur ctc especi ctc proport display close associ progress diagnosi surgeri chemotherapeut effect crc patient overal believ approach bring new understand ctc base liquid biopsi cancer diagnosi treatment
D009360;D015179
T191;T025
36,279,548
intramolecular c c bond format link anthraquinon enediyn scaffold tiancimycin biosynthesi first discov anthraquinon fuse enediyn class dna cleav bacteri natur product compos dna intercal anthraquinon moieti member enediyn warhead howev recent lack genet amen host sequenc biosynthet gene cluster avail solv biosynthet question surround molecul herein identifi biochem structur character tnmk member hydrolas fold superfamili respons c c bond format link anthraquinon moieti enediyn core togeth tiancimycin tnm biosynthesi two intermedi tnm h tnm anthraquinon fuse enediyn biosynthesi contain unpreced cryptic c aldehyd group identifi aldehyd play key role tnmk catalyz c c bond format via michael addit repres first exampl chemistri hydrolas fold superfamili addit tnm show sub nanomolar cytotox select cancer cell line indic new mechan action compar previous known anthraquinon fuse enediyn togeth find studi expect impact enzymolog natur product biosynthesi futur effort enediyn discoveri drug develop
D053281;D001688
T123;T121;T109
36,279,540
protocol crisprca mutagenesi orient fruit fli bactrocera dorsali orient fruit fli bactrocera dorsali high invas adapt pest speci caus damag citrus fruit crop worldwid sinc adult fruit fli great flight capac femal lay egg skin fruit insecticid requir direct contact pest usual perform poor field develop molecular biolog tool high throughput sequenc technolog mani scientist attempt develop environment friend pest manag strategi includ rnai gene edit base pesticid downregul silenc gene molecular target olfactori gene involv search behavior various insect pest adapt strategi orient fruit fli control effect method function gene research need gene critic function surviv reproduct b dorsali serv good molecular target gene knockdown andor silenc crisprca system reliabl techniqu use gene edit especi insect paper present systemat method crisprca mutagenesi b dorsali includ design synthesi guid rnas collect embryo embryo inject insect rear mutant screen protocol serv use guid generat mutant fli research interest function gene studi b dorsali
D007306;D033621
T131;T204
36,279,539
flow cytometri analysi murin bone marrow hematopoiet stem progenitor cell stromal nich cell bone marrow bm soft tissu found within bone hematopoiesi process new blood cell generat primarili occur contain hematopoiet stem progenitor cell hspcs well support stromal cell contribut mainten regul hspcs hematolog bm disord disrupt hematopoiesi affect hematopoiet cell direct andor alter bm nich describ method studi hematopoiesi health malign phenotyp analysi murin bm hspcs stromal nich popul flow cytometri method detail requir step enrich bm cell endost central bm fraction well appropri gate strategi identifi two key nich cell type involv hspc regul endotheli cell mesenchym stem cell phenotyp analysi propos may combin mous mutant diseas model function assay character hspc compart nich
D001853;D055153
T022;T023;T024
36,279,537
infrar thermographi detect chang brown adipos tissu activ measur brown adipos tissu bat activ positron emiss tomographi comput tomographi pet ct via accumul f fluorodeoxyglucos fdg meal obes diabet patient fail method choic main reason f fdg compet postprandi high glucos plasma concentr glucos transport membran bat cell addit bat use fatti acid sourc energi well visibl pet ct could chang along glucos concentr obes diabet patient therefor estim physiolog import bat anim human new infrar thermographi method use recent public appli overnight fast bat activ measur infrar thermographi meal human volunt femal wild type mice camera softwar calcul object temperatur use distanc object skin emiss reflect room temperatur air temperatur relat humid mice shave area bat region interest averag maxim temperatur measur phase estrous cycl femal mice determin experi vagin smear stain cresyl violet stain solut healthi volunt two skin area neck select supraclavicular area collarbon bat cell present interclavicular area collarbon bat tissu detect bat activ determin subtract two valu also averag maxim temperatur skin area could determin anim human particip chang bat activ meal measur infrar thermographi non invas sensit method shown sex age phase estrous cycl depend laboratori anim part diet induc thermogenesi bat activ human also proven sex age bodi mass index depend determin pathophysiolog chang bat activ meal great import particip high glucos plasma concentr obes diabet mellitus type well differ laboratori anim knock mice method also variabl tool determin possibl activ drug could rejuven bat activ
D002001;D019788
T130;T024;T109
36,279,536
construct cyclic peptid use tether sulfonium center recent year cyclic peptid attract increas attent field drug discoveri due excel biolog activ consequ use clinic therefor critic seek effect strategi synthes cyclic peptid promot applic field drug discoveri paper report detail protocol effici synthesi cyclic peptid use resin intramolecular intermolecular bisalkyl use protocol linear peptid synthes take advantag solid phase peptid synthesi cystein cys methionin met coupl simultan resin cyclic peptid synthes via bisalkyl met cys use tunabl tether tether sulfonium center whole synthet rout divid three major process deprotect cys resin coupl linker cyclize cys met trifluoroacet acid tfa cleavag solut furthermor inspir reactiv sulfonium center propargyl group attach met trigger thiol yne addit form cyclic peptid crude peptid dri dissolv acetonitril separ purifi high perform liquid chromatographi hplc molecular weight cyclic peptid confirm liquid chromatographi mass spectrometri lc ms stabil cyclic peptid combin reduct confirm use hplc addit chemic shift cyclic peptid analyz h nuclear magnet reson h nmr spectra overal protocol aim establish effect strategi synthes cyclic peptid
D010456;D003545
T123;T121;T116
36,279,535
isol character therapeut applic extracellular vesicl cultur human mesenchym stem cell extracellular vesicl ev heterogen membran nanoparticl releas cell type increas recogn physiolog regul organism homeostasi import indic patholog meantim immens potenti establish access control diseas therapeut emerg mesenchym stem cell mscs releas larg amount ev cultur shown promis jumpstart effect tissu regener facilit extens therapeut applic good scalabl reproduc grow demand simpl effect protocol collect appli msc ev detail protocol provid base differenti centrifug isol character repres ev cultur human mscs exosom microvesicl applic adapt method shown seri downstream approach label local transplant system inject implement procedur address need simpl reliabl msc ev collect applic translat research
D000067128;D059630;D055354
T026;T025
36,279,534
ex vivo analysi mechan activ ca transient urotheli cell mechan activ ion channel biolog transduc convert mechan stimuli stretch shear forc electr biochem signal mammal mechan activ channel essenti detect extern intern stimuli process divers touch sensat hear red blood cell volum regul basal blood pressur regul sensat urinari bladder full function mechan activ ion channel extens studi vitro set use patch clamp techniqu assess function nativ environ remain difficult task often limit access site express channel eg affer termin merkel cell baroreceptor kidney tubul difficulti appli patch clamp techniqu eg apic surfac urotheli umbrella cell protocol describ procedur assess mechan evok ca transient use fluoresc sensor gcampg ex vivo urotheli prepar techniqu could readili adapt studi mechan evok ca event nativ tissu prepar
D002118;D018862
T123;T196;T121;T025
36,279,533
integr workflow identif quantif fdr control base untarget metabolom untarget metabolom techniqu wide use recent year howev rapid increas throughput number sampl creat enorm amount spectra set challeng qualiti control mass spectrometri spectra reduc fals posit fals discoveri rate fdr qualiti control necessari recent develop softwar fdr control untarget metabolom identif base target decoy strategi name xy meta demonstr complet analysi pipelin integr xy meta metax togeth protocol show use xy meta generat decoy databas exist refer databas perform fdr control use target decoy strategi larg scale metabolom identif open access dataset differenti analysi metabolit annot perform run metax metabolit peak detect quantit order help research also develop user friend cloud base analysi platform analys without need bioinformat skill comput languag
D055442;D055432
T039;T070;T091
36,279,531
bridg technolog divid covid era use virtual outreach expos middl high school student imag technolog increas divers student choos career scienc technolog engin mathemat stem field area intens focus across usa especi kindergarten th grade k focus pipelin program medic school divers stem workforc contribut better problem solv equiti health care two mani major barrier rural student lack suffici stem role model limit access technolog classroom medic school often serv import resourc student local communiti easili gain access stem profession modern technolog campus sponsor event stem outreach local classroom howev underrepres minor urm student often live socioeconom distress part rural state arkansa access stem role model technolog limit virtual learn covid era proven imag technolog resourc medic school har reach wider audienc especi student live rural area far medic school campus
D000086382
T047;T067
36,279,530
phage mediat genet manipul lyme diseas spirochet borrelia burgdorferi introduc foreign dna spirochet borrelia burgdorferi almost exclus accomplish transform use electropor process notabl lower effici lyme diseas spirochet relat better character gram negat bacteria rate success transform high depend upon concentr amount high qualiti dna specif background subject signific strain strain variabl altern mean introduc foreign dna ie shuttl vector fluoresc report antibiot resist marker b burgdorferi could import addit armamentarium use tool genet manipul lyme diseas spirochet bacteriophag well recogn natur mechan movement dna among bacteria process call transduct studi method develop use ubiquit borreli phage bb transduc dna b burgdorferi cell differ genet background transduc dna includ borreli dna heterolog dna form small shuttl vector demonstr suggest potenti use phage mediat transduct complement electropor genet manipul lyme diseas spirochet report describ method induct purif phage bb b burgdorferi use phage transduct assay select screen potenti transduct
D025065;D001435;D008193
T005;T007;T047
36,279,529
electromagnet control close head model mild traumat brain injuri mice high reproduc anim model traumat brain injuri tbi well defin patholog need test therapeut intervent understand mechan tbi alter brain function avail multipl anim model tbi necessari model differ aspect sever tbi seen peopl manuscript describ use midlin close head injuri chi develop mous model mild tbi model consid mild produc structur brain lesion base neuroimag gross neuron loss howev singl impact creat enough patholog cognit impair measur least month injuri step step protocol induc chi mice use stereotax guid electromagnet impactor defin paper benefit mild midlin chi model includ reproduc injuri induc chang low mortal model tempor character year injuri neuroimag neurochem neuropatholog behavior chang model complementari open skull model control cortic impact use impactor devic thus lab model mild diffus tbi focal moder sever tbi impactor
D001924;D001930;D000070642
T037
36,279,528
mous model transit streptococcus pneumonia colon pathogen upon viral co infect recapitul age exacerb ill streptococcus pneumonia pneumococcus asymptomat colon nasopharynx individu progress pulmonari system pathogen upon influenza virus iav infect advanc age enhanc host suscept secondari pneumococc pneumonia associ worsen diseas outcom host factor drive process well defin part due lack anim model reproduc transit asymptomat colon sever clinic diseas paper describ novel mous model recreat transit pneumococci asymptomat carriag diseas upon viral infect model mice first intranas inocul biofilm grown pneumococci establish asymptomat carriag follow iav infect nasopharynx lung result bacteri dissemin lung pulmonari inflamm obvious sign ill progress lethal degre diseas depend bacteri strain host factor import model reproduc suscept age compar young mice old mice display sever clinic ill succumb diseas frequent separ carriag diseas distinct step provid opportun analyz genet variant pathogen host pneumoniaeiav co infect model permit detail examin interact import pathobiont host differ phase diseas progress model also serv import tool identifi potenti therapeut target secondari pneumococc pneumonia suscept host
D011018;D060085;D009980;D009976;D011008
T047;T005
36,279,527
isol small preantral follicl bovin ovari use combin fragment homogen serial filtrat understand full process mammalian folliculogenesi crucial improv assist reproduct technolog livestock human endang speci research most limit antral larg preantral follicl due difficulti isol smaller preantral follicl especi larg mammal bovin speci work present effici approach retriev larg number small preantral follicl singl bovin ovari cortex individu bovin ovari slice cube use tissu chopper homogen min rpm use mm probe larg debri separ homogen use chees cloth follow serial filtrat cell strainer content retain strainer rins search dish follicl identifi collect drop medium viabil collect follicl test via trypan blue stain method enabl isol larg number viabl small preantral follicl singl bovin ovari approxim min import method entir mechan avoid use enzym dissoci tissu may damag follicl follicl obtain use protocol use downstream applic isol rna rt qpcr immunoloc specif protein vitro cultur
D006080;D010053
T023
36,279,519
guidelin treatment follow patient q fever q fever queri fever zoonot infecti diseas worldwid distribut transmit intracellular gram negat bacterium coxiella burnetii common identifi sourc human infect farm anim sheep goat cattl diseas endem mainland portug case notifi central southern region q fever complex pleomorph diseas affect present wide rang manifest acut self limit flu like symptom good prognosi persist local form may harbor poor prognosi case might occur isol fashion follow outbreak great public health repercuss seen recent netherland given complex infect univers consensus date best strategi manag q fever patient guidelin provid recommend regard treatment follow patient base studi author experi opinion intern expert aim harmon manag patient take account clinic manifest also risk factor host order reduc diseas associ morbid mortal
D011778;D012757;D016997
T047;T007
36,279,518
sar cov antibodi preval portugues municip vila nova de gaia first wave pandem assess sar cov seropreval may detect real spread virus antibodi data provid long last measur infect exist serolog studi portug test new serolog method albeit small sampl size lack focus geograph region high rate infect case aim studi estim serolog preval sar cov vila nova de gaia popul municip north portug one affect first pandem wave
D058873;D000086382
T047;T067
36,279,511
prepar high concentr uniform size silver nanoparticl via use thermorespons zwitterion surfact despit popular use citrat reduct silver ion process suffer slow crystal growth broad size distribut rapid effect synthesi high concentr stabl spheric silver nanoparticl agnp confin surfact rich phase thermorespons alkyldimethylammonio propyl sulfat surfact obtain reaction citrat ion high temperatur describ present approach use zwitterion surfact offer altern rapid approach product agnp situ phase separ step serv extract concentr agnp surfact rich phase almost synthet yield extract effici synthes agnp diamet nm incorpor phase separ surfact rich phase ph capac maximum concentr particlesml agnp stabl upon long term storag least month
D012834;D053768
T196;T073
36,279,510
elucid role local nonloc rate enhanc mechan plasmon catalysi plasmon metal nanoparticl eg ag au cu constitut class materi interact light via excit local surfac plasmon reson lspr numer studi report substanti enhanc rate chemic reaction illumin plasmon nanoparticl catalyst compar correspond system absenc illumin two mechan propos explain lspr induc chemic reactiv one mechan assum local plasmon induc hot charg carrier mediat activ reactant assum lspr induc equilibrium heat catalyst lead energi transfer chemic reaction adsorb reactant contribut develop setup amen accur situ catalyst temperatur kinet reaction rate measur employ setup studi lspr induc rate enhanc case studi co oxid reaction plasmon monometal ag nanoparticl catalyst support al explor various ag load cluster level data show equilibrium heat catalyst fulli explain illumin induc plasmon rate enhanc case even high load cluster ag nanoparticl equilibrium heat signific increas base analysi propos local effect relat plasmon induc activ adsorb reactant via electron excit reactant phototherm heat reactant high local individu nanoparticl play critic role drive lspr induc chemic reaction
D053768
T073
36,279,508
develop vitro system emul vivo subcutan environ small molecul drug assess reliabl vitro system support guid develop subcutan sc drug product although sever vitro system develop limit may hinder get engag sc drug product develop studi sought develop novel vitro system name e mulat ub c utan bsorption r eleas escar better emul vivo sc environ predict fate drug sc deliveri escar design use comput aid design cad softwar fabric use three dimension print techniqu escar design two acceptor chamber repres blood uptak pathway lymphat uptak pathway respect although blood uptak pathway investig small molecul studi via conduct doe factor screen studi use acetaminophen solut relationship output drug releas sc chamber blood circul chamber input paramet could model use varieti method includ polynomi equat machin learn method mont carlo simul base method result suggest hyaluron acid ha concentr critic paramet wherea influenc inject volum inject posit substanti vitro vivo correl ivivc studi develop use griseofulvin suspens explor feasibl appli escar formul develop bioequival studi develop level ivivc model demonstr vivo pk profil could correl vitro releas profil therefor use model new formul vitro studi need conduct escar vivo studi might waiv conclus escar import implic research develop qualiti control sc drug product futur work would focus optim escar expand applic via assess type molecul formul
D040521
T024
36,279,506
elucid molecular structur hydrophob modifi polyethylenimin nanoparticl potenti implic dna bind structur properti polyethylenimin pei polym general tune select modifi reinforc potenti broad spectrum appli domain medicin healthcar materi design sens electron optim select modif polym bring chang interfaci characterist behavior current work involv synthesi naphthalimid conjug polyethylenimin organ nanoparticl npei onp interfaci molecular structur npei onp explor aqueous medium ph use surfac tensiometri sum frequenc generat vibrat spectroscopi sfg vs hydrophob function render concentr depend surfac coverag npei onp sfg vs analysi exhibit molecular rearrang hydrophob group interfac interact npei onp doubl strand dna dsdna carri observ relev synthes nanocomposit biomed domain bulk specif studi ie thermal denatur viscometri zeta potenti atr ftir reveal condens dsdna presenc npei onp make structur compact interfac sensit sfg vs showcas impact dsdna npei onp interact interfaci molecular behavior npei onp air aqueous interfac result exhibit potenti hydrophob function onp promis candid develop biomed sealant substrat coat biomed domain
D011094;D053758
T130;T073;T109
36,279,500
asymmetr synthesi methoxyl ether lipid total synthesi n polyunsatur docosahexaeno acid like methoxyl ether lipid first total synthesi docosahexaeno acid dha like methoxyl ether lipid mel report compound constitut cis methylen skip hexaen framework ident present dha well known omega polyunsatur fatti acid polyen c hydrocarbon chain bear methoxyl group posit r configur result chiral center attach ether linkag pro hydroxymethyl group sn posit glycerol backbon asymmetr synthesi high converg base polyacetylen approach involv iter copper promot coupl reaction propargyl bromid termin alkyn semihydrogen result hexayn start enantiopur r solket racem epichlorohydrin target mel accomplish yield eight step longest linear sequenc involv enantio diastereopur glyceryl glycidyl ether key c build block polyyn construct
D004281;D004986
T123;T121;T109
36,279,494
clinic nurs specialist transit practic qualiti improvementevid base practic project identifi critic compon clinic nurs specialist cns transit practic ttp need base experi percept entri level cnss n experienc cnss n director nurs n employ tertiari healthcar center structur minut face face discuss conduct
D009720
T097
36,279,493
nurs percept clinic nurs specialist role implement high special univers hospit spain qualit studi explor nurs percept clinic nurs specialist practic implement high special univers hospit spain
D009720
T097
36,279,492
nurs knowledg regard nurs surveil septic patient sepsi remain life threaten condit lead caus death unit state despit vast effort understand treat success sepsi treatment requir time implement sepsi bundl avoid multipl organ system failur key compon sepsi care nurs surveil purpos studi explor nurs knowledg nurs surveil relat patient sepsi describ barrier implement nurs surveil sepsi sepsi bundl
D009726;D018805
T047;T046;T097
36,279,491
pregnant covid chao insight women use inform perinat period pandem gain insight women use technolog address health inform need prenat postpartum time frame
D058873;D000086382
T047;T067
36,279,483
acquir diplopia adult heavi eye syndrom heavi eye syndrom condit result acquir progress strabismus due extrem myopia long axial length under pathogenesi condit due prolaps supero tempor aspect myopic globe caus displac later superior rectus muscl inferior nasal respect treatment heavi eye syndrom often target anatom defect seek place globe within extraocular muscl cone review discuss current theori pathogenesi treatment heavi eye syndrom
D004948;D013285;D015835
T033;T184;T047
36,279,482
clinic characterist acquir diplopia adult describ common caus symptomat strabismus treatment requir resolv diplopia adult patient seen one orthoptist
D004948;D013285
T047
36,279,481
evalu manag diverg insuffici type esotropia diverg insuffici type et common caus distanc diplopia elder adult recent prospect multicent data collect studi provid addit guidanc manag either base prism glass strabismus surgeri found high success rate base patient report diplopia health relat qualiti life domain score conclud either prism surgeri reason initi treatment strategi although alloc bias preclud formal comparison prism versus surgeri evid baselin differ group hint surgeri may yield superior outcom surgeri common approach bilater medial rectus recess high success assess week month postop unclear whether adjust sutur help vast major adjust case addit recess time adjust perform suggest larger standard surgic dose need
D004948;D013285
T047
36,279,480
evalu manag converg insuffici adult search perform literatur publish peer review journal disciplin relat eye care rehabilit purpos discov new think topic evalu manag converg insuffici adult nineti one paper review summar etiolog identif evalu manag converg insuffici popul report literatur present paper mani public address rehabilit traumat head injuri address manag converg insuffici consensus import complet patient examin includ complet sensorimotor examin care refract prior initi therapi chronic issu continu pauciti larg placebo control studi provid clear best practic provid addit healthcar profession eye care profess work patient converg insuffici without signific interprofession collabor
D015835
T033;T184;T047
36,279,479
evalu manag symptomat vertic strabismus diplopia evalu manag vertic strabismus challeng nuanc horizont strabismus vertic strabismus often result varieti restrict paret caus character either acquir congenit case identifi correct etiolog strabismus mean uncov potenti life threaten condit brain tumor stroke key identifi correct diagnosi first foremost care histori second detail examin characterist etiolog evalu vertic strabismus review
D004172;D013285
T033;T184;T047
36,279,477
lumi hof tb probe multipl ratiometr fluoresc chemiluminesc sens glucosidas innov assembl luminesc hydrogen bond organ framework hof multifunct optic sensor great signific develop advanc materi herein report facil room temperatur synthesi strategi luminol hof modifi tb lumi hof tb featur sensit chemiluminesc fluoresc characterist lumi hof tb pioneer dual signal sensor select detect glucosidas type enzym play crucial role digest carbohydr screen inhibitor sensor construct combin dual optic characterist luminol hof lanthanid ion assist hydrolysi glucosidas nitrophenyl glucopyranosid pngp substrat emerg fluoresc luminol p nitrophenol pnp complex nm chang inner filter absorpt recov tb characterist fluoresc nm luminol also produc chemiluminesc signal driven h addit glucos oxidas catalyz hydrolysi glucos fluoresc chemiluminesc assay glucosidas activ therefor establish exhibit detect limit low u l respect studi present possibl ln hof base sensor intellig optic materi integr fluoresc chemiluminesc techniqu also demonstr great potenti futur applic biosens
D000520;D008165
T121;T116;T109;T126;T130
36,279,475
combin enzym photoredox catalysi construct aminoalkyl chromon herein report practic effici strategi combin photoredox enzym catalysi construct aminoalkyl chromon hydroxyaryl enaminon n arylglycin ester varieti aminoalkyl chromon synthes good yield mild condit one pot synthet protocol consist sequenti enzymat hydrolysi photoredox decarboxyl n arylglycin ester oxid aminoalkyl radic mannich reaction intramolecular nucleophil cyclize afford conveni pathway prepar various substitut chromon
D002867;D004952
T109
36,279,474
recurr hippocampo neocort sleep state diverg human sleep assum unitari global state human anim coordin execut center brain stem hypothalamus basal forebrain howev common observ unihemispher sleep bird marin mammal well recent discov nonpatholog region sleep rodent call question whether whole human brain might also typic exhibit differ state brain area time analyz sleep state independ simultan record hippocamp depth electrod cortic scalp electrod eight human subject implant depth electrod pharmacolog intract epilepsi evalu found neocortex hippocampus could nonsimultan state averag one third night hippocampus often led asynchron state transit nonsimultan bout length vari min result call question conclus studi across phylogeni measur surfac cortic state seek assess function driver sleep state throughout brain
D019579
T023;T024
36,279,473
tnf ifn cooper effici pro anti inflammatori transit macrophag muscl regener ifn tradit known proinflammatori cytokin divers role antimicrobi antitumor immun yet find regard sourc function regener process follow steril injuri conflict show natur killer nk cell main sourc ifn regener muscl beyond cell popul ifn product limit small popul cell show nk cell play major role muscl regener follow acut injuri dystroph mice surpris absenc ifn per se also effect muscl regener follow acut injuri howev role ifn partial unmask tnf also neutral suggest compensatori mechan use transgen mice show condit inhibit ifngr signal muscl stem cell fibro adipogen progenitor play major role muscl regener contrast common belief found ifn present earli inflammatori phase regener process rather peak macrophag acquir anti inflammatori phenotyp transcriptom analysi suggest ifn cooper tnf regul transit macrophag pro anti inflammatori state absenc cooper effect cytokin macrophag howev result signific regener impair like due presenc compensatori mechan find support aris view ifn pleiotrop inflammatori regul rather induc inflammatori respons
D014409;D008264
T129;T116;T025
36,279,472
mechan voltag gate voltag sens phosphatas ci vsp conform chang voltag sens domain vsds driven transmembran electr field act protein charg yet overal energet detail mechan process fulli understood determin free energi displac charg landscap well major conform visit complet function gate cycl isol vsd phosphatas ci vsp ci vsd compris four transmembran helic segment molecular dynam simul highlight extent movement addit crystallograph determin activ rest state simul predict two ci vsd conform deeper rest state minus extend activ plus state addit conform experiment probe via systemat cystein mutagenesi metal ion bridg engin proton conduct mutant hyperpolar voltag present result show four state visit sequenti stepwis manner voltag activ step transloc one arginin equival e across membran electr field yield transfer e charg total complet process
D015640;D011522
T196;T043
36,279,471
topolog gelat reconnect polym dna recombin ubiquit process ensur genet divers contrari textbook pictur dna recombin well generic dna transloc occur confin high entangl environ inspir observ investig solut semiflex polym ring undergo generic cut reconnect oper spheric confin setup may realiz use engin dna presenc recombinas protein consid micell like compon abl form live revers breakabl polym ring find system topolog gelat transit trigger increas either stiff concentr ring flexibl dilut polym break ensembl short unlink segreg ring wherea suffici stiff dens polym self assembl network long link mix loop mani knot predict two phase behav qualit differ elut experi monitor escap dynam permeabil contain besid shed light biophys topolog genom undergo dna reconnect vivo find could leverag vitro design polymer complex fluid eg dna base complex fluid live polym network desir topolog
D011108;D008823
T104;T122;T109
36,279,470
intrins nonlinear dynam drive singl speci system import oscil determinist chao natur biolog system discuss sever decad origin base discret time popul growth model may recent type nonlinear dynam shown experiment communiti sever speci interact yet data exhibit whole rang nonlinear dynam singl speci system without trophic interact ecolog experi model ignor intracellular dimens includ multipl nonlinear process even within one cell type show dynam singl speci system protist continu experiment chemostat system correspond continu time model reveal typic characterist nonlinear dynam even determinist chao rare discoveri automat cell registr enabl continu undisturb analysi dynam behavior high tempor resolut simpl general model consid cell cycl exhibit remark spectrum dynam behavior chao like dynam shown continu singl speci popul experiment model data level singl type cell without extern forc studi demonstr complex process occur singl cell influenc dynam popul level nonlinear consid import phenomenon cell biolog singl speci dynam also mainten high biodivers natur prerequisit natur conserv
D017711;D056890
T077;T170;T204
36,279,469
hippocamp gamma sharp waverippl mediat bidirect interact cortic network sleep hippocampus neocortex interact sleep critic memori process hippocamp initi replay contribut memori consolid neocortex hippocamp sharp waverippl modul cortic activ yet spatial tempor pattern interact unknown voltag imag electrocorticographi laminar resolv hippocamp potenti character cortico hippocamp signal anesthesia nonrapid eye movement sleep observ neocort activ transient statist suggest quasi critic regim may help communic across remot brain area activ transient identifi data driven fashion three function network network overlap default mode network center retrospleni cortex associ hippocamp activ hippocamp slow gamma rhythm strong associ neocort transient even rippl fact neocort activ predict hippocamp slow gamma follow rippl suggest consolid process reli bidirect signal hippocampus neocortex
D019579;D000069077
T041;T023;T024
36,279,467
larg effect loci mediat rapid adapt salmon bodi size river regul understand potenti natur popul adapt alter environ becom increas relev evolutionari research current understand adapt human alter environ hamper lack knowledg genet basi trait lack time seri littl inform chang optim trait valu use time seri data span near centuri investig bodi mass atlant salmon salmo salar adapt river regul found chang bodi mass follow chang waterflow decreas origin valu allel frequenc chang two loci region vgll six predict observ bodi mass reduct model adapt dynam reveal popul mean lag behind optimum catch approxim six salmon generat initi waterflow reduct result demonstr rapid adapt mediat larg effect loci provid insight tempor dynam evolutionari rescu follow human disturb
D020317
T013
36,279,466
experiment test nicotin hypothesi covid pathophysiolog mechan under constel symptom character covid incomplet understood effort fill gap nicotin hypothesi posit nicotin acetylcholin receptor achr act addit sever acut respiratori syndrom coronavirus sar cov receptor recent put forth key featur propos potenti clinic ramif suggest competit virus spike protein small molecul cholinerg ligand receptor orthoster bind site notion reminisc well establish role muscl achr rabi virus infect address hypothesi direct perform equilibrium type ligand bind competit assay use homomer human achr express intact cell receptor radio label bungarotoxin bgtx orthoster site compet ligand test differ sar cov spike protein peptid domain entir ectodomain found none appreci outcompet bgtx specif manner furthermor patch clamp record show clear effect domain achr mediat current conclud bind sar cov spike protein human achr orthoster site thus competit ach cholin nicotin unlik relev aspect complex diseas
D000086382;D011978
T047;T116;T067;T192