PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,235,012 | polydatin pharmacolog mechan therapeut target biolog activ health benefit polydatin natur potent stilbenoid polyphenol resveratrol deriv improv bioavail polydatin possess potenti biolog activ predomin modul pivot signal pathway involv inflamm oxid stress apoptosi various imper biolog activ suggest polydatin toward promis therapeut effect includ anticanc cardioprotect anti diabet gastroprotect hepatoprotect neuroprotect anti microbi well health promot role renal system respiratori system rheumatoid diseas skelet system women health present studi therapeut target biolog activ pharmacolog mechan health benefit polydatin review provid new insight research need develop clinic trial novel deliveri system polydatin also consid reveal new insight research | D059808;D013267 | T121;T109 |
36,235,011 | molecular structur analysi specif mutat saudi isol sar cov rna depend rna polymeras implic protein structur drug protein bind covid pandem caus sever acut respiratori syndrom coronavirus sar cov stress global health system signific level result high morbid mortal also pose threat futur pandem situat warrant effort develop novel therapeut manag sar cov specif emerg virus general studi focus sar cov rna depend rna polymeras rdrp mutat collect saudi arabia impact protein structur function saudi sar cov rdrp sequenc compar refer wuhan china rdrp use varieti comput biophys base approach result reveal three mutat av pi yc may affect protein stabil henc relationship protein structur function apo wild rdrp dynam stabl compact secondari structur element compar mutant wild type show stabl conform dynam interact network remdesivir net bind energi wild type rdrp remdesivir kcalmol stabl mutant find current studi might deliv use inform regard therapeut develop mutant rdrp may furnish understand sar cov biolog | D000086382;D000086402 | T047;T067;T005 |
36,235,010 | mass spectrometr proof predict peptid novel adipokinet hormon insect import insect ecosystem undeni indiscrimin use broad spectrum insecticid factor declin insect biomass identifi sequenc promin neuropeptid hormon insect overarch goal elucid related creat databas bioactiv peptid could inform possibl cross activ biolog assay identif biorat lead compound major task adipokinet hormon akh insect regul metabol event carbohydr lipid breakdown storag tissu intens muscular work genom andor transcriptom inform one may predict gene encod neuropeptid akh insect definit elucid primari structur matur peptid putat post translat modif need analyt chemic method use high resolut mass spectrometri coupl liquid chromatographi identifi unequivoc akh five insect speci one cockroach two moth two fli either genomictranscriptom inform avail sequenc relat speci confirm predict sequenc discov novel akh sequenc includ one post translat hydroxyprolin modif addit sequenc affirm evolutionari pattern dipteran akh conserv pattern crambid moth | D007301;D007306;D009036;D009479 | T116;T131;T109;T123;T125;T204 |
36,235,009 | biomimet target theranost nanoparticl breast cancer treatment develop biomimet drug deliveri system biomed applic attract signific research attent use cell membran surfac coat shown promis platform sever diseas treatment cell membran coat nanoparticl exhibit enhanc immunocompat prolong circul time herein human red blood cell rbc membran cloak nanoparticl enhanc target function design target nanotheranost cancer natur deriv human rbc membran modifi target ligand coat onto polymer nanoparticl core contain chemotherapi imag agent use epitheli cell adhes molecul epcam posit mcf breast cancer cell diseas model natur inspir target theranost human red blood cell membran coat polymer nanoparticl tt rbc nps platform capabl specif bind target cancer cell effect deliv doxorubicin dox also visual target cancer cell tt rbc nps achiev extend releas profil major drug releas occur within day tt rbc nps enabl enhanc cytotox efficaci epcam posit mcf breast cancer non target nps addit fluoresc imag target cancer cell incub tt rbc nps visual indic increas cellular uptak tt rbc nps insid breast cancer cell taken togeth tt rbc np platform set foundat next generat stealth theranost platform system cargo deliveri treatment diagnost cancer | D001943;D053758 | T191;T073 |
36,235,008 | new green approach nanoparticl synthesi overview nanotechnolog constant expand nanomateri use common commerci product defin modern life among type nanomateri nanoparticl nps occupi import place consid great amount produc nowaday divers applic convent techniqu appli synthes nps issu imped appreci safe environ health altern might use live organ biolog extract involv green approach synthesi nps process free harm chemic cost effect low energi consum sever factor includ biolog reduc agent concentr initi precursor salt concentr agit reaction time ph temperatur light influenc characterist biolog synthes nps interdepend reaction paramet explor main impedi implement biolog method industri scale aim present brief review focus current knowledg regard aforement factor control size shape green synthes nps also provid overview biomolecul found suitabl np synthesi work meant support research intend develop new green approach synthesi nps | D053768;D053758 | T073 |
36,235,007 | chemic profil cyperus laevigatus protect effect thioacetamid induc hepatoren toxic rat cyperus speci repres group cosmopolitan plant use folk medicin treat sever diseas current studi phytochem profil cyperus laevigatus ethanol extract clee assess use uplc qtof msms protect effect clee mg kg bodi weight bw evalu hepatoren injuri induc thioacetamid mgkg via investig extract effect oxid stress inflammatori marker histopatholog chang liver kidney uplc qtof msms analysi clee result identif compound includ organ phenol acid flavon auron fatti acid clee improv antioxid status liver kidney manifest enhanc reduc glutathion gsh coenzym q coq addit reduct malondialdehyd mda nitric oxid hydroxi deoxyguanosin ohdg moreov clee posit affect oxid stress paramet plasma thwart deplet hepatoren atp content thioacetamid taa furthermor treatment rat clee allevi signific increas plasma liver enzym kidney function paramet inflammatori marker protect effect clee confirm histopatholog studi liver kidney result propos clee may reduc taa hepatoren toxic via antioxid anti inflammatori properti suppress oxid stress | D029786;D047309 | T109;T002 |
36,235,006 | unveil antimicrobi antioxid composit differ dukkah zaatar via spme gcms hplc dad interest plant base diet rise recent year owe potenti health benefit individu compon notion plant base diet might reduc incid sever diseas egyptian dukkah syrian zaatar two histor famous middl eastern herbal blend use anti inflammatori hypolipidem antidiabet effect headspac spme gcms hplc dad adopt character aroma profil phenol compound herbal blend respect vapor phase minimum inhibitori concentr employ assess blend antibacteri potenti antioxid potenti estim via vitro antioxid assay spme headspac analysi indic abund ether monoterpen hydrocarbon hplc reveal presenc sever phenol includ rosmarin acid ferul acid rutin biolog investig affirm vapor phase test blend exhibit antibacteri activ gram posit gram negat pathogen antioxid potenti blend investig express trolox eqmg edta edta eqmg equival present studi offer first insight chemic profil biolog activ dukkah zaatar | D000890;D000975 | T121;T044;T123;T039 |
36,235,005 | interact fungal metabolit harzian acid rare earth cation pr eu ho tm rare earth element ree respect class new contamin may toxic effect organ microorgan inform interact natur ligand valu predict control diffus natur environ current studi investig interact triposit cation praseodymium europium holmium thulium harzian acid h l secondari metabolit produc select strain fungi belong trichoderma genus appli techniqu workflow previous employ analog studi concern lanthanum neodymium samarium gadolinium triposit cation therefor current studi hplc esi hrms experi circular dichroism cd uv vis spectrophotometr absorpt data well accur ph measur appli character bond interact harzian acid pr eu ho tm cation problem connect low solubl harzian acid water overcom employ naclo ch oh h w w mix solvent pr ho tm mono complex prl hol tml detect format constant determin eu form almost exclus bis complex eul correspond format constant report experiment condit mono complex eul irrelev combin result present previous studi pictur interact harzian acid rare earth cation extend ree compos order complement chemic inform toxicolog inform batteri bioassay appli evalu effect praseodymium europium holmium thulium triposit cation suit bioindic includ aliivibrio fischeri gram negat bacterium raphidoc subcapitata green alga daphnia magna microcrustacean median effect concentr ec valu pr eu ho tm test speci assess | D008674;D011221 | T196 |
36,235,004 | potenti role plantmacrofungialga deriv non starch polysaccharid coliti cure review possibl mechan action multipl vitro vivo model investig suggest broad spectrum potenti mechan plantmacrofungi deriv non starch polysaccharid may play role treatment inflammatori bowel diseas ibd articl review vivo vitro evid differ plant deriv polysaccharid ibd therapi under mechan particular molecular mechan associ protect effect treatment prevent idb well summar includ anti inflammatori epitheli barrier repair regul intestin flora emerg studi observ potent role probiot ibd particular abil modul gut microbiota well known key factor ibd summari plantmacrofungi deriv polysaccharid potenti promis agent adjuv treatment prevent ibd contribut design well design clinic intervent trial ultim improv therapi ibd | D003092;D015212;D019936 | T007;T047 |
36,235,003 | recent advanc mass spectrometri base structur elucid techniqu mass spectrometri ms becom central techniqu extens use analysi molecular structur unknown compound gas phase manipul molecul convert ion use various ionize sourc high resolut ms accur molecular weight mw intact molecular ion measur assign molecular formula high confid furthermor applic tandem ms enabl detail structur character break intact molecular ion proton deproton molecul key fragment ion approach use structur elucid small molecul mw lt da also crucial biopolym protein polypeptid therefor ms extens use multiom studi reveal structur function import biomolecul interact high sensit ms enabl analysi low level analyt complex matric also versatil techniqu coupl separ techniqu includ chromatographi ion mobil mani analyt instrument nmr review aim focus technic advanc ms base structur elucid method past five year provid overview applic complex mixtur analysi hope review interest wide rang audienc may extens experi ms base techniqu | D010455;D053719 | T121;T063;T116 |
36,235,002 | determin cyclaniliprol fruit veget use dispos pipett extract cleanup ultrahigh perform liquid chromatographi tandem mass spectrometri despit outstand agent control lepidoptera diamid insecticid cyclaniliprol cycp suspect carcinogen present studi analyt method develop determin cycp six fruit veget appl grape peach bell pepper lettuc tomato use ultrahigh perform liquid chromatographi coupl tandem mass spectrometri sampl prepar carri acetonitril salt extract follow simpl fast cleanup dispos pipett extract tip contain styren divinyl benzen andor graphit carbon black satisfactori linear r gt obtain calibr rang g ml matrix effect decreas cleanup recoveri cycp three spike level mg kg differ matric intra day n inter day n relat standard deviat lower limit quantif mg kg develop method provid good refer routin monitor cycp fruit veget | D007306;D010573 | T131 |
36,235,001 | simultan predict determin extract four polycycl aromat hydrocarbon environ use ucon nah po aqueous two phase extract system combin high perform liquid chromatographi ultraviolet detect paper new aqueous two phase extract system atp consist ucon poli ethylen glycol ran propylen glycol monobutyl ether nah po establish four trace polycycl aromat hydrocarbon pah fluoren anthracen pyren phenanthren water soil analyz high perform liquid chromatographi hplc ultraviolet detect multi factor experi central composit design ccd use determin optimum technolog condit final optim condit follow concentr ucon gml concentr nah po moll temperatur c recoveri four target relat standard deviat ucon recycl cyclic test design experi result show recoveri pah gradual increas three extract remain pah salt phase last extract recoveri pah ucon recycl test less extract test due wastag ucon addit two phase aqueous extract model establish base random forest rf model result obtain compar experiment data root mean squar error rmse correl coeffici r prove model robust reliabl | D010616;D011084;D014874 | T121;T109;T131 |
36,235,000 | applic hplc fingerprint combin chemic pattern recognit multi compon determin qualiti evalu echinacea purpurea l moench echinacea purpurea ep common medicin materi extract anti rsv compon howev effect simpl method comprehens reflect qualiti ep current studi qualiti echinacea purpurea l moench sampl six differ cultiv locat china evalu establish high perform liquid chromatographi hplc fingerprint combin chemic pattern recognit multi compon determin studi chemic fingerprint common peak obtain use similar evalu system chromatograph fingerprint tradit chines medicin edit among compon three phenol acid caftar acid chlorogen acid cichor acid identifi determin similar fingerprint batch echinacea purpurea l moench sampl rang similar fingerprint five batch commerci avail echinacea pupurea l moench standard fingerprint r rang prove success establish fingerprint pca hca perform relat peak area common peak peak refer peak variabl anhui shaanxi success distinguish four cultiv area addit index compon caftar acid chlorogen acid cichor acid rang mgg mgg mgg result multi compon index content determin show content shandong cultiv area higher follow gansu henan hebei lowest anhui shaanxi result consist pca hca prove qualiti echinacea purpurea l moench differ origin differ hplc fingerprint combin chemic pattern recognit multi compon content determin reliabl comprehens prospect method evalu qualiti echinacea purpurea l moench method provid scientif basi qualiti control evalu echinacea purpurea l moench | D020900 | T002 |
36,234,999 | evalu corioli micro air sampl detect volatil semi volatil organ compound sever analyt procedur avail monitor volatil organ compound voc air differ main sampl procedur corioli micro air sampler tool normal design biolog air sampl paper corioli micro bio collector use evalu abil sampl organ contamin sampl detect combin gc ms also compar use corioli micro standard sampl method use lung box nalophan bag result show corioli micro sampl method suitabl sampl organ contamin inde corioli micro allow sampl detect main semi volatil molecul lung boxnalophan bag allow sampl volatil molecul high volatil volatil result confirm control air lab slight differ field simultan use techniqu allow sampl detect larger number molecul specif physicochem properti sampl techniqu conclus corioli micro sampl detect volatil organ compound present air shown develop altern sampl method use non target analysi essenti comprehens risk assess moreov use corioli micro allow detect emerg molecul around thau lagoon | D055549 | T109 |
36,234,997 | toxic analysi mesopor polydopamin intestin tissu microflora promis therapi phototherm therapi ptt convert near infrar nir light heat effici phototherm agent ptas caus rapid increas local temperatur consid import ptas clinic applic ptt safeti ptas care evalu widespread use promis pta mesopor polydopamin mpda studi clinic applic tumor phototherm therapi drug deliveri given import role intestin microflora play health impact mpda intestin intestin microflora systemat evalu studi biolog anim experi found mpda exhibit excel biocompat vitro vivo moreov rrna analysi demonstr obvious differ composit classif intestin microflora differ drug deliveri group control group result provid new evid mpda safe use larg dose via differ drug deliveri mean lay foundat clinic applic | D000069196;D006979;D053758 | T007;T001;T061;T073 |
36,234,996 | polym support poli ethylen glycol phase transfer catalyst cross aldol condens isobutyroaldehyd formaldehyd immobil poli ethylen glycol peg ps use effect phase transfer catalyst synthesi hydroxypivaldehyd isobutyraldehyd iba formaldehyd presenc inorgan base studi influenc paramet cours reaction batch reactor show use peg ps catalyst allow one obtain hpa high effici iba convers gt select gt relat short time mild condit h c develop method enabl easi separ post reaction mixtur simpl phase separ immobil catalyst separ filtrat use five time without loss activ high activ stabil catalyst also confirm test carri flow reactor | D011092;D011108 | T122;T121;T109;T130;T104 |
36,234,995 | effect dri techniqu phytochem content biolog activ select bamboo leav therapeut potenti bamboo acquir global attent nonetheless biolog activ plant rare consid due limit avail refer sabah malaysia furthermor dri techniqu could signific affect retent degrad nutrient bamboo consequ current studi investig five dri method name sun shade microwav oven freez dri leav six bamboo speci bambusa multiplex bambusa tuldoid bambusa vulgari dinochloa sublaevigata gigantochloa levi schizostachyum brachycladum infus bamboo leav extract analys total phenol content tpc total flavonoid content tfc antioxid activ sampl determin via diphenyl picrylhydrazyl dpph azino bis ethylbenzothiazolin sulfon acid abt ferric reduc antioxid power frap assay wherea toxic evalu brine shrimp lethal assay bsla chemic constitu sampl determin use liquid chromatographi tandem mass spectrometri lc msms freez dri method exhibit highest phytochem content antioxid activ yield exclud b vulgari sampl microwav dri sampl record antioxid phytochem level tpc tfc result within mg gallic acid equival gae g mg quercetin equival qe g rang respect dpph abt ic half maxim inhibitori concentr gml respect indic high radic scaveng activ frap valu differ signific dri method within mg trolox equival te g rang phytochem content antioxid capac exhibit moder correl reveal tpc tfc slight respons antioxid activ toxic assess bamboo extract current studi demonstr toxic bsla base lc lethal concentr analysi gt gml lc ms analysi show alkaloid pharmaceut compound influenc antioxid activ found previous studi acquir inform might aid develop bamboo leav function food item bamboo tea could also investig medicin ingredi use discoveri potenti drug | D000975;D010936 | T121;T044;T123;T039 |
36,234,994 | synthesi novel benzimidazol base thiazol deriv multipot inhibitor amylas glucosidas vitro evalu along molecular dock studi studi hybrid analog benzimidazol contain thiazol moieti afford test abil inhibit amylas glucosidas compar acarbos standard drug recent avail analog show wide varieti inhibitori potenti rang amylas glucosidas posit control acarbos ic amylas ic glucosidas structur activ relationship sar studi carri analog base substitut pattern around ring b c respect conclud sar studi analog bear either substitu smaller size f cl substitu capabl form hydrogen bond oh catalyt residu target enzym enhanc inhibitori potenti therefor analog bear meta fluoro substitut para fluoro substitut ortho fluoro group show enhanc potenc evalu standard acarbos drug ic valu amylas glucosidas correspond hand analog bear substitu either bulki natur br incap form hydrogen bond ch found lower inhibitori potenti order investig bind site synthet analog interact activ area target enzym molecular dock studi also conduct potent analog result show analog adopt mani import interact activ area enzym precis structur newli synthes compound confirm use sever spectroscop techniqu nmr hrei ms | D000516;D000520 | T121;T126;T116 |
36,234,993 | microbi degrad spectral analysi toxicolog assess malachit green dye streptomyc exfoliatus malachit green mg dye common environment pollut threaten human health integr earth ecosystem aim studi investig potenti biodegrad mg dye actinomycet speci isol plant soil near industri water effluent cairo egypt streptomyc isol st select accord high effici laccas product identifi exfoliatus base phenotyp rrna molecular analysi deposit ncbi genbank gene access number ol growth kinet studi incub time h growth rate h duplic time td multipl rate mr h mg decolor valu h incub c eleven physic nutrit factor mannitol fri oil wast mgso nh nh cl dye concentr ph agit temperatur inoculum size incub time screen signific biodegrad mg exfoliatus use pbd eleven factor screen pbd five dye concentr fri oil wast mgso inoculum size ph shown signific decolor process central composit design ccd appli optim biodegrad mg maximum decolor attain use follow optim condit food oil wast mll mgso gl dye concentr gl ph inoculum size product degrad mg exfoliatus character use high perform liquid chromatographi hplc gas chromatographi mass spectrometri gc ms result reveal presenc sever compound includ leuco malachit green di tert butyl phenylethoxi silan benzenedicarboxyl acid bis ethylhexyl ester benzenedicarboxyl acid bis ethylhexyl ester benzenedicarboxyl acid di n octyl phthalat benzenedicarboxyl acid dioctyl ester moreov phytotox microbi toxic cytotox test confirm byproduct mg degrad toxic plant microb human cell result work implic exfoliatus novel strain mg biodegrad differ environ | D004785;D013302 | T007;T131 |
36,234,992 | journey diastereomer space design synthesi vitro vivo pharmacolog activ molecular model novel potent diastereomer mor agonist antagonist four set diastereomer c alkenyl phenylmorphan vari length c alkenyl chain design examin effect spatial distinct ligand opioid receptor function activ obtain forskolin induc camp accumul assay sever compound examin gtpgs assay assay respiratori depress four set similar differ observ depend length c alkenyl chain import stereochemistri three mor antagonist found potent naltrexon unlik naltrexon none mor kor dor agonist activ sever potent mor full agonist obtain particular interest partial agonist found exhibit less respiratori depress caus morphin effect stereochemistri length c alkenyl chain also explor use molecular model mor antagonist found interact inact dkl mor crystal structur agonist found interact activ ddf mor crystal structur comparison bind mode mous mor use gain insight structur basi stereochem induc pharmacolog differ | D009271;D012131 | T121;T047;T109;T046 |
36,234,991 | effect environment electr perturb pka thioredoxin cystein comput studi present theoret comput studi deal evalu pka cystein residu thioredoxin trx complex thioredoxin interact protein txnip free energi differ anion neutral form cystein evalu mean perturb matrix method classic perturb due environ exogen electr field provid molecular dynam md simul evalu free energi allow us show effect perturb term lower pka cystein cystein respect free amino acid hand complex trx txnip data show enhanc stabil neutral reduc form cys result suggest extern electr stimuli higher vnm modul cystein pka connect tight regul trx act antioxid agent | D000975;D003545 | T116;T121;T123;T044;T039 |
36,234,990 | adera drug repurpos workflow neuroimmunolog investig use neural network drug repurpos context neuroimmunolog ni investig still primari stage drug repurpos import method bypass lengthi drug discoveri procedur focus discov new usag known medic neuroimmunolog diseas alzheim parkinson multipl sclerosi depress includ various patholog result interact central nervous system immun system howev repurpos ni medic hinder vast amount inform need mine previous present adera capabl text mine pubm answer queri base question howev adera abl automat identifi chemic compound within relev sentenc challeng need repurpos known medic neuroimmunolog diseas built deep neural network name adera perform drug repurpos workflow use three deep learn network first network encod main task emb text matric second network use mean squar error mse loss function predict answer form embed matric third network constitut main novelti updat workflow also use mse loss function main usag extract compound name relev sentenc result previous network optim network function compar eight differ design found deep neural network consist rnn neural network leaki relu could achiev loss sensit addit valid adera abil predict ni drug usag drug repurpos hub databas result establish abil adera repurpos drug candid shorten develop drug cycl workflow could download onlin | D058492;D016571 | T061;T062;T170 |
36,234,988 | cyclen function cobalt substitut sandwich type tungstoarsen versatil remov methylen blue anti ros sensit tumor cell oxid degrad use reactiv oxygen speci ros effect method treat pollut synthesi artifici oxidas degrad dye hot spot molecular scienc studi nanoscal sandwich type polyoxometal pom basi tetra nuclear cobalt cluster trivac b keggin type tungstoarsen co c h n co h hasw h abbrevi caw c h n cyclen synthes structur examin infrar ir spectrum ultraviolet visibl uv vis spectrum x ray photoelectron spectrum xps singl crystal x ray diffract sxrd bond valenc sum calcul accord structur analysi princip element caw deriv modifi sandwich type polyanion co h hasw four co cyclen tetraazacyclododecan cyclen first appli modifi pom also demonstr caw capabl effici catalyz product ros synergist effect pom fragment co cyclen complex moreov caw interfer morpholog prolifer sensit cell produc ros exhibit abil specif elimin methylen blue mb dye solut system adsorpt catalyt oxid | D000080027;D004785 | T131;T109;T123 |
36,234,987 | biodegrad petroleum hydrocarbon drechslera spicifera isol contamin soil riyadh saudi arabia current bioremedi petroleum hydrocarbon employ microbi biosurfact public accept biolog safeti low cost organ degrad detoxifi organ contamin area marin ecosystem current studi aim test oil biodegrad abil fungus drechslera spicifera isol contamin soil sampl riyadh saudi arabia use hydrocarbon toler scan electron microscopi dcpip drop collaps emulsif activ recoveri biosurfact germin assay assess biodegrad characterist spicifera kerosen crude diesel use mix oil result dcpip show highest oxid au induc crude oil th day contrast kerosen use oil highest measur emulsif activ drop collaps assay respect meanwhil crude use oil produc highest amount biosurfact acid precipit solvent extract assay furthermor biosurfact stimul germin tomato seed compar control find highlight biodegrad abil spicifera proven use petroleum oil sole sourc carbon might encourag research demonstr applic clean larg contamin area | D010578;D012989 | T109;T131 |
36,234,986 | neuroprotect effect polyphenol extract terminalia chebula retz cerebr ischemia reperfus injuri current therapi ischem stroke insuffici due lack specif drug studi aim investig protect activ polyphenol extract terminalia chebula cerebr ischemia reperfus induc damag polyphenol ethyl acet n butanol fraction extract chebula bv microgli cell expos oxygen glucos deprivationreoxygen mice subject middl cerebr arteri occlusionreperfus treat tpe tpb cell viabil cell morpholog apoptosi mitochondri membran potenti enzym activ signal pathway relat oxid stress observ found tpe tpb show strong antioxid activ vitro protect effect tpe tpb cerebr ischemia reperfus injuri demonstr enhanc antioxid enzym activ elev level nucleus transport nuclear factor erythroid relat factor express antioxid protein simultan reduct cell apoptosi reactiv oxygen speci level conclus tpe tpb exert neuroprotect effect stimul nrf signal pathway therebi inhibit apoptosi | D018696;D015427;D029766 | T121;T169;T002;T037 |
36,234,985 | applic singl molecul vibrat spectroscop techniqu structur investig amyloid oligom amyloid oligomer speci form misfold process believ play major role neurodegen metabol diseas deepen knowledg structur amyloid intermedi aggreg pathway essenti understand under mechan misfold cytotox howev structur investig challeng due low abund heterogen metast intermedi speci singl molecul techniqu potenti overcom difficulti review aim report recent advanc applic vibrat spectroscop techniqu structur analysi amyloid oligom special focus singl molecul studi | D000682;D000686 | T047;T123;T116 |
36,234,983 | supramolecular tool improv wound heal antioxid properti abiet acid biocompat microemuls emulgel abiet acid natur occur fir resin compound exhibit anti inflammatori wound heal properti formul biocompat emulgel base stabl microemuls addit carbam contain surfact carbopol gel various microemuls emulgel formul test antioxid wound heal properti chemiluminesc method shown composit contain abiet acid high antioxid activ use strat skin model membran found emulgel signific prolong releas abiet acid wistar rat shown microemuls emulgel contain wt abiet acid promot rapid heal incis wound twofold tissu reinforc compar untreat group document tensiometr wound sutur ruptur assay high heal effici associ combin antibacteri activ formul compon anti inflammatori action abiet acid | D000975;D014945 | T121;T123;T040;T044;T039 |
36,234,982 | effect ozon applic microbiolog stabil content sugar bioactiv compound fruit saskatoon berri amelanchi alnifolia nutt saskatoon berri fruit valuabl sourc micro macronutri sugar compound health promot properti properti chang storag studi present effect appli gaseous ozon ppm min microbiolog stabil sugar content bioactiv compound three cultivar three clone saskatoon berri fruit ozon process posit effect reduc microbi load fruit observ day storag two variant ozon time min compar control also sugar profil thiessen fruit well clone type h compar control sampl non ozon fruit saskatoon berri fruit analyz polyphenol compound identifi four belong anthocyanin group whose main repres glucosid cyanidin ascorb acid content antioxid activ determin dpph abt method vari accord cultivar clone saskatoon berri fruit analyz ozon exposur time | D010126;D027824 | T103;T002 |
36,234,981 | box behnken extract design hepatoprotect effect isol eupalitin galactopyranosid boerhavia diffusa linn object studi optim quantifi maximum percentag yield eupalitin galactopyranosidefrom boerhavia diffusa leav use respons surfac methodolog rsm well demonstr hepatoprotect benefit bioactiv compound box behnken experiment design util optim eupalitin galactopyranosid extract procedur also look extract durat temperatur solvent concentr independ variabl boerhaviadiffusa leav extract n hexan chloroform ethyl acet water use fraction dri extract dri ethyl acet fraction thorough mix hot methanol store overnight refriger cold methanol filter solid separ hot methanol use mani time crystal solid obtain pure eupalitin galactopyranosid w w propos hptlc method valid quantif eupalitin galactopyranosidewassuccess valid develop linear r detect limit ng quantif limit ng method well rang ng inter intraday precis rsd specif accuraci rsd valid satisfactori separ eupalitin galactopyranosid band achiev hptlc plate use toluen aceton water v v develop system box behnken statist design use determin best optim method found extract time min temperatur c solvent ratio methanol water v v eupalitin galactopyranosid standard silymarin rang gml gml term signific high hepatoprotect cell induc carbon tetrachlorid wherea isol eupalitin galactopyranosid rang gml gml recent sourc structur uniqu flavonoid compound may offer opportun develop novel semi synthet molecul | D039281;D012838 | T121;T109;T002 |
36,234,980 | camellia seed cake extract support hair growth abrog effect dihydrotestosteron cultur human dermal papilla cell autocrin paracrin factor play key role process androgenet alopecia aga secret bald dermal papilla cell dpcs dihydrotestosteron dht induct camellia seed cake orient oil extract byproduct extract tradit use wash hair china studi elucid hair growth promot effect camellia seed cake extract csce dht treat cultur dpcs under mechan effect csce cell viabil releas inflammatori factor il il perform human dermal papilla cell dpcs incub dht relat express bax bcl p androgen receptor ar reductas type ii srda determin pcr senesc associ examin galactosidas sa gal assay csce restor dht induc cell damag dose depend manner effect reduc product il il dht treat dpcs csce exhibit anti apoptot effect increas express bcl decreas express bax p dht incub dpcs csce also show anti androgen effect revers increas ar srda express dpcs driven dht incub addit csce inhibit galactosidas enzym activ slow cell senesc dpcs crucial aga progress studi found csce may potenti prevent allevi aga abrog effect dht cultur dpcs | D028244;D013196 | T002;T121;T109;T123;T125 |
36,234,979 | remov anion cation dye present solut use biomass eichhornia crassip bioadsorb discharg larg amount effluent contamin gentian violet gv phenol red pr threaten aquat flora fauna well human health effluent must treat discard studi seek remov dye use water lili eichhornia crassip adsorb differ pretreat pr gv analyz uv visibl spectrophotomet equilibrium experiment data show freundlich best model fit pr sip gv show adsorpt process dye heterogen favor chemic gv physic pr thermodynam analysi adsorpt process dye depend direct increas temperatur carri spontan pseudo first order pfo kinet model gv pr best fit dye adsorpt capac mgg respect character materi demonstr signific chang band lignin cellulos hemicellulos indic function group could particip captur dye togeth electrostat forc medium conclud adsorpt process carri sever mechan | D031806;D014874 | T131;T002 |
36,234,978 | recent progress identifi bacteria fluoresc probe develop new techniqu rapid accur detect bacteria drawn continu attent due potenti threat pose bacteria human health safeti recent novel strategi base fluoresc probe drawn consider interest detect bacteria due high select fast respons simpl oper review summar recent progress fluoresc probe specif recognit discrimin gram negat gram posit bacteria particular outlin current design strategi target differ surfac compon cell wall compon endogen enzym surfac charg hydrophob various kind bacteria develop various fluoresc sensor organ small molecul fluoresc probe nanoprob metal ion probe also emphas applic organ molecul probe recognit element hope review stimul research area bacteri detect imag futur | D001419;D005456 | T007;T130 |
36,234,977 | magnolol potenti anticanc agent propos mechanist insight cancer serious diseas high mortal morbid worldwid natur product serv major sourc develop new anticanc drug recent decad magnolol repres natur phenol lignan isol magnolia officinali attract consider attent anticanc properti recent year accumul preclin studi demonstr tremend therapeut potenti magnolol via wide rang pharmacolog mechan cancer review summar latest advanc preclin studi investig anticanc properti magnolol describ import signal pathway explain under mechan magnolol capabl inhibit cancer growth metastasi various cancer type magnolol exert anticanc effect inhibit prolifer induc cell cycl arrest provok apoptosi restrain migrat invas suppress angiogenesi multipl signal pathway also involv pharmacolog action magnolol cancer pikaktmtor signal mapk signal nf b signal base exist evid summar review conclus confirm magnolol multi target anticanc effect heterogen cancer diseas promis develop magnolol drug candid cancer therapi futur | D000970;D001688;D017705 | T121;T109;T123 |
36,234,976 | ph respons inorganicorgan nanohybrid system control nicotin acid drug releas although nicotin acid na sever clinic benefit potenc fulli util due sever undesir side effect includ cutan flush git associ symptom etc overcom issu improv na efficaci new inorgan organ nanohybrid system ration design make hybrid system na intercal ldh coprecipit techniqu coat eudragit make final drug deliveri system call eudragit coat na ldh made drug deliveri system improv na releas profil also exhibit good bio compat test l cell inorgan organ nanohybrid drug deliveri agent expect reduc undesir side effect associ na hope improv pharmacolog effect without induc undesir toxic | D009525 | T121;T109;T127 |
36,234,975 | electrolyt analysi blood serum laser induc breakdown spectroscopi use portabl laser fast reliabl analysi electrolyt k na ca human blood serum becom indispens tool diagnos prevent diseas laser induc breakdown spectroscopi lib demonstr power analyt techniqu element appli lib quantit analysi electrolyt element real time self develop portabl laser use measur blood serum sampl support glass slide filter paper work partial least squar regress plsr method employ predict concentr k na ca serum lib spectra great predict accuraci excel linear obtain serum sampl glass slide filter paper blood serum glass slide predict accuraci k na ca moreov blood serum filter paper correspond predict accuraci result show lib use portabl laser assist plsr use accur quantit analysi element blood serum real time work reveal handheld lib instrument excel tool real time clinic practic | D007834;D044967 | T031;T074;T073 |
36,234,974 | antimicrobi v shape copper ii pentaiodid insight bond pattern suscept antimicrobi resist amr major concern surviv mankind covid acceler anoth silent pandem amr uncontrol use antibiot biocid new generat antimicrobi agent need combat resist pathogen crown ether use model drug action similar antibiot iodin well known microbicid character instabl short term effect iodin stabil form polyiodid rich topolog depend immedi surround addit copper success use sinc begin histori biocid agent therefor combin iodin copper high select crown ether tetraoxacyclododecan crown morpholog composit new pentaiodid cu crown investig antimicrobi activ select pathogen studi found c albican wdcm high suscept cu crown addit compound good intermedi antimicrobi activ gram posit gram negat bacilli chain like pentaiodid structur v shape consist iodin molecul short coval bond connect triiodid halogen bond singl crystal structur arrang across lattic fring form ribbon honeycomb suscept microorgan toward polyiodid depend polyiodid bond pattern halogen coval non coval bond | D000890;D000086382;D043844;D004202;D007455 | T047;T167;T131;T121;T109;T123;T196;T067 |
36,234,973 | mix micellar solubil naphthol green b follow remov synthet effluent micellar enhanc ultrafiltr optim condit manuscript applic cetyltrimethylammonium bromid ctab cetylpyridinium chlorid cpc remov naphthol green b ngb synthet effluent studi solubil ngb singl mix micellar system use triton x tx nonion surfact perform establish extent partit k x ngb ultim respect gibb free energi g p well appli methodolog micellar enhanc ultrafiltr meuf also studi differ micellar media cation surfact variat select paramet concentr surfact electrolyt pressur ph rpm obtain optimum condit result analyz uvvis doubl beam spectrophotomet g p found kjmol kjmol ctab cpc respect presenc nonion surfact maximum valu gibb free energi g p partit obtain cpc valu reject coeffici r permeat flux j also calcul maximum remov ctab cpc respect obtain observ surfact strong candid ngb remov | D008823;D014462 | T061;T109 |
36,234,972 | extract knoxia roxburghii spreng rau induc apoptosi human mcf breast cancer cell via mitochondri pathway knoxia roxburghii spreng rau kr plant clinic use tradit chines medicin tcm treatment cancer studi object examin effect kr extract petroleum ether pet ethyl acet etoac butanol n buoh h solubl fraction hsf etoh extract non small cell lung cancer hepg liver cancer hela cervic cancer mcf breast cancer l normal hepatocyt cell found hsf exhibit strongest cytotox activ mcf cell accompani reduc mitochondri transmembran potenti increas level intra cellular reactiv oxygen speci ros activ caspas upregul pro apoptot downregul anti apoptot protein lc ms analysi show hsf primarili consist calycosin alo emodin rein maackiain asperulosid orientin vicenin kaempferid most report anti tumor activ previous studi summari current studi illustr effect mechan potenti major activ compon kr breast cancer | D000972;D001943;D002289;D008175;D019666 | T121;T002;T191 |
36,234,971 | use cyclotid scaffold target biomolecular interact drug develop review provid overview properti cyclotid potenti develop novel peptid base therapeut select disrupt protein protein interact remain challeng interact surfac relat larg flat howev high constrain polypeptid base molecular framework cell permeabl properti cyclotid scaffold shown great promis target biomolecular interact use molecular techniqu epitop graft molecular evolut employ cyclotid scaffold shown high effect select bioactiv cyclotid | D047169 | T116 |
36,234,970 | synthesi graphen base nanocomposit environment remedi applic review term graphen coin use prefix graph taken graphit suffix ene cc bond boehm et al synthesi graphen done use various method synthes graphen oxid graphen oxid go use differ method enhanc multitud applic graphen oxid go oxid analog graphen familiar intermedi precursor obtain latter larg scale graphen oxid recent obtain enorm popular energi environ sensor biomed field handsom exploit water purif membran go uniqu class mechan robust ultrathin high flux high select foul resist separ membran provid opportun advanc water desalin technolog facil synthesi go membran open door ideal next generat membran cost effect sustain altern long exist thin film composit membran water purif applic mani type go metal oxid nanocomposit use erad problem metal ion halomethan organ pollut differ color water bodi make water fit use furthermor enhanc applic gomet oxid nanocomposit deposit polymer membran water purif due relat low cost clear pore form mechan higher flexibl compar inorgan membran along applic use nanocomposit prepar membran result excel foul resist also could possibl solut overcom trade water permeabl solut select henc gomet oxid nanocomposit could improv overal perform includ antibacteri properti strength rough pore size surfac hydrophil membran review highlight structur synthesi graphen well graphen oxid decor polymer membran applic | D004785;D052918;D006108;D053761 | T073;T131;T069;T109;T196 |
36,234,969 | effect substrat perform microstructur properti phosphat chemic convers coat metal surfac phosphat chemic convers pcc technolog attract extens attent abil regul surfac properti biomed metal howev titanium ti base alloy exhibit inertia nativ passiv layer wherea zinc zn base alloy show high activ acid pcc solut substrat perform affect chemic reaction phosphat solut lead divers coat properti work zinc phosphat znp coat prepar ti alloy ta zn alloy za substrat use pcc method respect coat prepar herein detect scan electron microscop sem x ray diffractomet xrd laser scan confoc microscop lscm univers test machin contact angl goniomet electrochem workstat system result show substrat perform littl effect phase composit signific affect crystal microstructur thick bond strength coat addit znp coat improv surfac rough substrat show good hydrophil electrochem corros resist format mechan znp coat reveal use potenti time curv indic metal solut interfaci reaction play domin role deposit process | D000497;D014025 | T196;T197 |
36,234,967 | impact control sugar size glycoconjug vaccin glycoconjug vaccin contribut enorm reduc control encapsul bacteri infect thirti year glycoconjug vaccin base carbohydr antigen coval link carrier protein necessari caus cell respons optim immunogen protect young children mani interdepend paramet affect immunogen glycoconjug vaccin includ size saccharid antigen examin discuss impact glycan chain length efficaci glycoconjug vaccin report method employ size polysaccharid antigen highlight under reaction mechan better understand impact key paramet immunogen glycoconjug critic develop new generat high effect vaccin | D006001;D000073893 | T121;T109 |
36,234,966 | discoveri novel boron contain n substitut oseltamivir deriv anti influenza virus agent overcom n hy oseltamivir resist address drug resist influenza virus neuraminidas inhibitor nai seri novel boron contain n substitut oseltamivir deriv design synthes target caviti neuraminidas na na inhibitori assay found new compound exhibit moder inhibitori potenc wild type nas among compound c bear boron acid benzyloxi benzyl group display weaker slight improv activ group nas hn hn hn hn hy compar oseltamivir carboxyl osc encourag c show time greater activ osc toward hn hy na moreov c exert equival potent antivir activ osc hn hn hn addit c demonstr low cytotox vitro acut toxic dose mgkg mice molecular dock c employ provid possibl explan improv anti hy na activ may due format key addit hydrogen bond surround amino acid residu arg gln val taken togeth c appear promis lead compound optim | D053118;D053124;D009980 | T005 |
36,234,965 | artemisia speci high biolog valu potenti sourc medicin cosmet raw materi artemisia speci play vital role tradit contemporari medicin among artemisia abrotanum artemisia absinthium artemisia annua artemisia dracunculus artemisia vulgari popular chemic composit bioactiv speci extens studi studi speci confirm tradit applic document new pharmacolog direct valuabl potenti applic cosmetolog artemisia ssp primarili contain sesquiterpenoid lacton coumarin flavonoid phenol acid essenti oil obtain speci great biolog import extract artemisia ssp scientif proven exhibit among other hepatoprotect neuroprotect antidepress cytotox digest stimul activ addit applic cosmet product current subject sever studi essenti oil extract differ part artemisia ssp character antibacteri antifung antioxid activ product artemisia extract essenti oil individu compound use skin hair nail artemisia product also use ingredi skincar cosmet cream shampoo essenc serum mask lotion tonic review focus especi elucid import popularimport speci artemisia genus cosmet industri | D019306;D031172;D003358;D009822 | T167;T109;T073;T002 |
36,234,964 | interact isoquinolin alkaloid transit metal iron copper data alkaloid interact physiolog import transit metal iron copper most lack literatur howev interact import consequ treatment alzheim diseas cancer isoquinolin alkaloid includ galanthamin approv drug alzheim diseas well potenti use compound cytostat potenti member categori alkaloid select complex screen interact iron copper four pathophysiolog relev ph non buffer condit dimethyl sulfoxid spectrophotometr method vitro except salt alkaloid abl chelat ferrous ferric ion non buffer condit five galanthin glaucin corydin corydalin tetrahydropalmatin evok signific chelat ph first two also activ ph contrast none test alkaloid chelat cuprous cupric ion alkaloid except protopin signific reduc ferric cupric ion stronger effect latter effect most depend number free aromat hydroxyl hydroxyl group potent reduct boldin alkaloid chelat reduc ferric ion addit experiment studi need elucid biolog relev result chelat expect block reactiv oxygen speci format reduct could opposit effect | D000544;D054697 | T121;T047;T048 |
36,234,963 | nano theranost construct terpyridin modifi pillar aren base supramolecular amphiphil applic cell imag cancer therapi theranost play import role cancer treatment due realiz real time track therapeut efficaci situ work design synthes terpyridin modifi pillar aren tp coordin terpyridin zn complex tp zn obtain supramolecular amphiphil construct use host guest complex polyethylen glycol contain guest pm tpzn combin fluoresc properti terpyridin group amphiphil system obtain tpznpm self assembl fluoresc particl diamet nm water obtain particl effect load anti cancer drug realiz live cell imag precis releas drug | D000970;D009369 | T121;T109;T191 |
36,234,962 | potenti kalancho pinnata cancer treatment adjuv epigenet regul cancer global public health problem relat differ environment lifestyl factor although combin screen prevent treatment cancer result increas patient surviv convent treatment sometim therapeut limit resist drug sever side effect orient cultur includ herbal medicin complementari therapi combin chemotherapi radiotherapi studi aim identifi bioactiv ingredi kalancho pinnata succul herb ethnomed applic sever diseas includ cancer reveal anticanc mechan molecular approach herb contain gallic acid caffeic acid coumar acid quercetin quercitrin isorhamnetin kaempferol bersaldegenin bryophyllin bryophyllin c bryophynol bryophyllol bryophollon stigmasterol campesterol element phytochem particip regul prolifer apoptosi cell migrat angiogenesi metastasi oxid stress autophagi potenti act epigenet drug revert acquir epigenet chang associ tumor resist therapi promot methyl suppressor gene inhibit dnmt dnmtb activ hdac regul methyl therebi regul express gene involv pikaktmtor nrfkeap mekerk wnt catenin pathway data support use k pinnata adjuv cancer treatment | D031962 | T002 |
36,234,961 | collis cross section predict molecular fingerprint use machin learn high resolut mass spectrometri promis techniqu non target screen nts monitor contamin emerg concern complex sampl current chemic identif strategi nts experi typic depend spectral librari chemic databas silico fragment tool howev small molecul identif remain challeng due lack orthogon sourc inform eg uniqu fragment collis cross section ccs valu measur ion mobil spectrometri im offer addit identif dimens increas confid level thank advanc analyt instrument increas applic im hybrid high resolut mass spectrometri hrms nts report recent decad sever ccs predict tool develop howev limit ccs predict method base larg scale chemic class cross platform ccs measur success develop two predict model use random forest machin learn algorithm one approach base chemic super class model direct ccs predict use molecular fingerprint ccs valu six differ laboratori pubchem use varieti ion mobil separ techniqu use train test model test accuraci predict model median relat residu around model appli differ im platform elimin fals posit small molecul identif | D000075663;D054852 | T059;T170 |
36,234,960 | prepar biocomposit natur reinforc effect nativ starch sugarcan bagass fiber biocomposit prepar poli lactic acid two natur reinforc nativ starch sugarcan bagass fiber strength interfaci adhes estim model calcul local deform process follow acoust emiss test result show two addit influenc properti differ strength interfaci adhes thus extent reinforc similar similar chemic structur larg number oh group reinforc relat strong interfaci adhes develop compon render coupl ineffici dissimilar particl characterist influenc local deform process consider smaller particl size starch result larger debond stress thus larger composit strength fractur bagass fiber lead larger energi consumpt increas impact resist although environment benefit prepar biocomposit similar overal perform bagass fiber reinforc pla composit better offer plastarch composit | D002482;D031786 | T002;T109;T123;T122 |
36,234,959 | inhibitori effect gras essenti oil plant extract growth aspergillus westerdijkia aspergillus carbonarius strain effect essenti oil obtain use hydrodistil plant extract ethanol aqueous hexan extract differ plant cultiv brazil test use diffus agar method object evalu inhibitori effect oil extract myceli growth aspergillus westerdijkia nrrl carbonarius rc unrc essenti oil plant extract analyz oregano essenti oil plant extract rosemari essenti oil clove ethanol extract best choic obtain growth paramet radial growth rate mm day lag phase h due good result present volum oilextract obtain compar essenti oil plant extract test growth paramet best result obtain clove ethanol extract strain assay result demonstr outstand potenti use product prevent fungal contamin food howev studi need conduct determin abil oil extract inhibit reduc ochratoxin product | D009822;D010936 | T121;T109;T123 |
36,234,958 | gas phase observ solid state realiti identif isol trinuclear salicylaldoximato copper complex condit identifi phenol aldoxim ketoxim type use commerci solvent extract process doubli deproton generat polynuclear cu complex lower extract cu molar ratio found commerci oper electrospray mass spectrometri provid insight solut speciat extract experi identifi condit allow isol character polynuclear cu complex elev ph effect enhanc format trinuclear complex contain planar cu cu oh unit dft calcul suggest trinuclear complex stabl polynuclear speci solid structur complex form salicylaldoxim piperidino substitu ortho phenol oh group l h contain two trinuclear unit supramolecular assembl cu oh l h clo clo form h bond central cu oh unit oxygen atom ligand adjac complex whilst lower ligand cu molar ratio provid effici cu load solvent extract process requir rais ph aqueous phase achiev make impract commerci oper extract accompani precipit oxyhydroxid fe iii present signific quantiti feed solut generat acid leach cu ore | D003300;D005290 | T121;T104;T123;T196 |
36,234,957 | detect quantif alprazolam ad long drink near infrar spectroscopi chemometr present work fast relat cheap green analyt strategi identifi quantifi fraudul voluntari addit drug alprazolam api xanax alcohol drink larg consumpt name gin tonic develop use coupl near infrar spectroscopi nir chemometr approach use qualit quantit model built would allow highlight presenc alprazolam high accuraci quantifi concentr mani case accept error classif model built use partial least squar discrimin analysi pls da allow identifi whether drink spike drug predict accuraci valid phase often higher hand calibr model establish use partial least squar pls regress allow quantifi drug ad error order mgl | D000525;D019265 | T121;T109;T059 |
36,234,956 | polyphenol rich ginger zingib officinal iron defici anaemia clinic entiti associ alter iron metabol ginger zingib officinal rich natur polyphenol may potenti complement oral iron therapi treat prevent iron defici anaemia ida narrat review explor benefit ginger ida clinic entiti associ alter iron metabol vivo vitro limit human studi ginger supplement shown enhanc iron absorpt thus increas oral iron therapi efficaci also reduc oxid stress inflamm thus protect excess free iron ginger bioactiv polyphenol prebiot gut microbiota promot gut health reduc unwant side effect iron tablet moreov ginger polyphenol enhanc effect erythropoiesi case iron overload due comorbid chronic inflammatori disord ginger potenti revers advers impact restor iron balanc ginger also use synthesis nanoparticl sustain develop newer effect oral iron product function ingredi ida treatment prevent research still need explor applic ginger polyphenol iron balanc anaem condit specif long term well design control trial requir valid effect ginger adjuv treatment ida | D000740;D020939;D000090463;D019190 | T047;T002 |
36,234,954 | product biochem character kineticthermodynam studi inulinas aspergillus terreus urm inulinas enzym involv hydrolysi inulin use food industri produc high fructos syrup fructo oligosaccharid purpos differ aspergillus strain substrat test inulinas product solid state ferment among aspergillus terreus urm grown wheat bran show highest activ u ml inulinas produc strain exhibit optimum activ c ph detail kineticthermodynam studi perform inulin hydrolysi reaction enzym thermal inactiv inulinas shown high affin substrat evidenc low micha constant valu mm togeth low activ energi kj mol indic good enzym catalyt potenti moreov long half life min high valu min c suggest great thermost confirm thermodynam paramet thermal denatur name activ energi thermal denatur e kj mol gibb free energi g kj mol result indic terreus urm inulinas promis effici biocatalyst could fruit exploit long term industri applic | D006026;D007444 | T116;T121;T109;T126;T130 |
36,234,953 | isol structur character biolog activ two acid polysaccharid fruit elaeagnus angustifolia linnaeus elaeagnus angustifolia linnaeus medicin plant fruit pharmacolog activ antiinflammatori antiedema antinocicept muscl relax function etc two acid homogen polysaccharid eap h eap h isol fruit elaeagnus angustifolia l deae sephadex g column chromatographi physicochem structur properti biolog activ polysaccharid investig eap h eap h compos rha ara xyl glc gal molar ratio respect molecular weight kda kda respect result obtain fourier transform infrar spectroscopi ftir confirm polysaccharid natur isol substanc congo red assay confirm exist tripl helix structur scan electron microscopi sem x ray diffract xrd analysi reveal eap h eap h irregular fibrous filament like surfac crystallin amorph structur bioactiv analysi show crude polysaccharid eap h eap h clear dpph abt free radic scaveng activ could promot secret phagocyt activ raw thp cell show clear antioxid immuno regulatori activ result indic elaeagnus angustifolia l fruit acid polysaccharid may potenti valu pharmaceut function food industri | D031263;D005638 | T168;T002 |
36,234,952 | convers superoxid hydroperoxid cobalt iii depend structur electron properti azol base chelat ligand convers superoxid hydroperoxid ooh metal center oxygenas oxidas recogn key step generat activ speci substrat oxid studi reactiv cobalt iii superoxido complex support facial cap trident tris dimethyl x pyrazolyl hydrobor hb pz x tp x bident bis methyl imidazolyl methylbor b im n ly ligand toward h atom donat reagent hydroxi azaadamantan azadol explor oxygen cobalt ii precursor give correspond cobalt iii superoxido complex follow reaction azadol yield hydroperoxido speci character spectroscopi uv vis reson raman epr reaction cobalt iii superoxido speci reduc reagent co ii c h cobaltocen proton trifluoroacet acid tfa also yield correspond cobalt iii hydroperoxido speci kinet analys format rate cobalt iii hydroperoxido complex reveal second order rate constant depend structur electron properti cobalt support chelat ligand electron withdraw ligand opposit superoxid acceler hydrogen atom transfer hat reaction azadol due increas electrophil superoxid ligand shield cobalt center alkyl group boron center bis imidazolyl borat ligand hinder approach azadol superoxid although steric effect insignific | D003035;D013481 | T121;T109;T123;T196 |
36,234,951 | eco friend quaternari ammonium salt corros inhibitor carbon steel hcl solut theoret experiment investig corros industri materi cost problem associ global econom loss reach trillion us dollar repair failur inject corros inhibitor practic promis method deceler corros reaction protect surfac recent investig focus surfact corros inhibitor due amphiphil natur low cost simpl chemic prepar procedur studi aim investig perform environ friend quaternium q surfact wide use cosmet c steel corros inhibit hcl medium weight loss experi perform differ concentr immers time present maximum effici mmoll influenc q corros behavior c steel elucid use non destruct electrochem measur overal result reveal ad vari concentr q signific decreas corros rate c steel result reveal physisorpt natur q onto c steel surfac adsorpt follow freundlich isotherm had kjmol relat inhibit perform q also evalu sem afm analys last quantum chemic calcul base densiti function theori dft demonstr q promis molecular featur concern anticorros mechan | D002244;D013232 | T121;T196;T122 |
36,234,950 | quantif acipimox plasma tissu lc msms applic pharmacokinet comparison normoxia hypoxia studi aim evalu pharmacokinet acipimox rat simul high altitud hypoxia condit sensit reliabl lc msms method establish quantit acipimox rat plasma tissu homogen valid accord guidelin european medicin agenc ema us food drug administr fda western blot enzym link immunosorb assay elisa use investig express lipid metabol relat protein free fatti acid ffa level respect cell viabil detect use cell count kit assay cck method success appli pharmacokinet comparison normox hypox rat result indic signific differ main pharmacokinet paramet acipimox normox hypox rat hcar express hypoxia group upregul compar normoxia group level ffa decreas hypoxia group hypoxia condit prolifer hk cell inhibit increas concentr acipimox result provid import valuabl inform safeti efficaci acipimox indic dosag acipimox might adjust appropri clinic medic hypoxia | D005230;D012844 | T116;T121;T109;T123;T125 |
36,234,949 | chemic profil biolog activ essenti oil piper arboreum develop improv mouthwash studi show consum use natur health product modern world notic grow demand market profession communiti mouthwash contain natur compound object studi assess chemic character microbiolog potenti essenti oil piper arboreum eopa provid data enabl develop low cost mouthwash evalu antibacteri bacteri resist modul activ perform microdilut method determin minimum inhibitori concentr chemic compon character gas chromatographi coupl mass spectrometri identifi chemic constitu caryophyllen oxid one major compound eopa show mic gml bacteri strain use test evalu modul activ eopa combin chlorhexidin mouthwash antibiot bacteri resist oil limit synergist activ mic product test combin therefor recommend expand test greater variat eopa concentr product use well toxic assess vivo test purpos develop possibl low cost mouthwash base access vulner popul | D009822;D031701 | T109;T002 |
36,234,948 | cheminformat model gene silenc natur chemic modifi sirna design effect sirna specif mrna target critic import predict model potenc sirna none publish method character chemic structur individu nucleotid constitut sirna molecul therefor predict potenc gene silenc chemic modifi sirna cm sirna propos new approach predict potenc gene silenc cm sirna character nucleotid nt use bcut cheminformat descriptor describ charg distribut hydrophob polar properti thus nt sirna molecul describ descriptor result concaten bcut valu compos nucleotid partial least squar employ develop statist model huesken data natur sirna molecul use perform model build evalu natur sirna result compar superior huesken algorithm bramsen dataset cm sirna use build test model cm sirna predict r result model reach pearson r valu thus new method use success model gene silenc potenc natur chemic modifi sirna molecul | D000080911;D020868 | T045;T170 |
36,234,947 | elsholtzia ciliata thunb hyland review phytochemistri pharmacolog paper confus sourc medicin materi briefli expound differ among varieti point time chemic compon pharmacolog properti elsholtzia ciliata thunb hyland e ciliata review structur compound identifi list main includ flavonoid terpenoid phenylpropanoid alkaloid chemic compon antioxid anti inflammatori antimicrobi insecticid antivir hypolipidem hypoglycem analges antiarrhythm antitumor antiacetylcholinesteras immunoregul activ present mani research use essenti oil alcohol extract research antioxid anti inflammatori anti microbi pharmacolog activ relat matur paper aim summar exist research updat research progress regard phytochem pharmacolog e ciliat provid conveni subsequ research | D000890;D019686;D009822 | T121;T109;T002 |
36,234,946 | visibl light photoelectrochem sensor dopamin determin use iron vanad modifi electrod studi report facil approach construct low cost remark electroact iron vanad fe v semiconductor materi use photoelectrochem sensor dopamin detect structur morpholog iron vanad obtain success ionic adsorpt reaction process critic character photoelectrochem character show high photoelectroact photoanod visibl light irradi best condit dopamin detect chronoamperometri v vs agagcl achiev two linear respons rang mol l mol l limit detect quantif mol l respect besid accuraci propos electrod assess determin dopamin artifici cerebrospin fluid obtain recoveri valu rang select also evalu dopamin detect sever interfer speci demonstr good precis promis applic propos method furthermor dft base electron structur calcul also conduct help interpret domin dopamin speci determin accord experiment condit interact iron vanad photoanod propos improv light induc dop detect likewis evalu regard charg transfer process | D015374;D004298 | T059;T121;T075;T123;T109 |
36,234,945 | enrich quercetin winemak residu diatomac earth via tailor made imprint adsorb residu diatomac earth rde winemak activ rich current underexploit sourc phenol compound ought recycl perspect circular bioeconomi work demonstr feasibl molecular imprint polym mip enrich quercetin flavonoid fair high content residu diatomac earth mip synthes free radic polymer ftir confirm integr function monom polymer chain batch adsorpt experi use assess retent select mip toward quercetin commerci resin compar synthes materi use procedur adsorpt experi allow select best perform mip valor rde extract treatment consist satur select mip extract desorb retain compound use solvent select composit desorb fraction analyz use liquid chromatographi result demonstr increas quercetin fraction area rde extract fraction rough eightfold enrich quercetin moreov flavonoid close chemic structur quercetin rather retain enrich mip | D054802;D011794 | T121;T109;T127;T063 |
36,234,944 | recombin thaumatin like protein rtlp chitinas rchi viti vinifera model wine haze format cross link net aggreg thermolabil thaumatin like protein tlps chitinas chis primari sourc haze white wine although bentonit fine still routin use winemak altern method select remov haze protein without affect wine organolept properti need avail pure tlps chis would facilit research identif technolog advanc therefor propos usag recombin tlp rtlp chi rchi express komagataella phaffii haze protein model sinc show similar characterist aggreg potenti melt point function glycosyl level bentonit adsorpt nativ haze protein viti vinifera henc rtlp rchi appli studi haze format mechan molecular level explor altern fine method screen proteolyt enzym ideal adsorpt resin | D002688;D027843;D014920 | T116;T002;T126;T168;T129 |
36,234,943 | polygonum capitatum hmong medicin flora comprehens review phytochem pharmacolog pharmacokinet characterist polygonum capitatum known tou hua liao chines name crucial sourc hmong medicin plant benefit human health long time folk medicin plant wide distribut south west china treatment various urolog disord includ urinari tract infect pyelonephr urinari calculus purpos paper provid systemat comprehens overview tradit usag botani phytochemistri pharmacolog pharmacokinet clinic applic flora end least compound report p capitatum main cover class flavonoid lignanoid phenol compon compound extract isol p capitatum exhibit wide rang pharmacolog activ anti inflammatori antioxid antimicrobi anticanc analges hypotherm diuret pharmacolog effect qualit quantit chemic analys also cover furthermor possibl develop trend perspect futur research medicin plant also discuss | D010946;D028502 | T002 |
36,234,942 | evalu antimicrobi anticanc anti inflammatori antioxid activ silver nanoparticl synthes leaf extract madhuca longifolia util quantit qualit method current decad nanoparticl synthes use solvent environment friend number nanoparticl synthes room temperatur use water solvent gold au silver ag nanoparticl part nanotechnolog nanoparticl synthes biolog process biolog method prefer method synthesi inorgan nanoparticl agnp result simpl non hazard natur nanoparticl silver use varieti applic includ catalyst spectral select coat solar absorpt optic object pharmaceut constitu chemic biolog sens antimicrobi agent among top use silver nanoparticl current studi silver nanoparticl biolog manufactur madhuca longifolia antibacteri activ pathogen microorgan anticanc anti inflammatori antioxid activ assess uv vis spectroscopi xrd x ray diffract transmiss electron microscopi zeta potenti ftir use character silver nanoparticl current work describ cheap environment friend method synthes silver nanoparticl silver nitrat solut use plant crude extract reduc agent | D000890;D032128;D053768 | T121;T073;T002 |
36,234,941 | structur insight ksiii ketoacyl acp synthas like acyltransferas chlb biosynthesi chlorothricin chlorothricin chl belong spirotetron antibiot famili produc streptomyc antibioticus inhibit pyruv carboxylas malat dehydrogenas biosynthesi chl chlb play crucial role introduc methylsalicyl acid msa moieti chlb acyl carrier protein acp howev structur insight catalyt mechan chlb unclear current studi crystal structur chlb solv resolut catalyt mechan propos basi conserv residu structur relat enzym chlb dimer activ site cerj structur homolog enzym use ksiii like fold work acyltransferas relax substrat specif chlb defin catalyt effici k cat k non acp tether synthet substrat msa snac acetyl snac cyclohexonyl snac chlb success detach msa moieti msa snac substrat hydrolyt activ demonstr chlb potenti catalyz non acp tether substrat structur comparison indic chlb belong fabh famili show root mean squar deviat rmsd structur homolog enzym molecular dock dynam simul implement understand substrat activ site structur behavior open close conform chlb protein result catalyt substrat recognit mechan suggest chlb potenti use non nativ substrat minim labor express acp protein versatil acyltransferas activ may pave way manufactur chl variant may help hydrolyz sever thioester base compound | D015099;D000213 | T126;T116;T123 |
36,234,940 | spice volatilom fingerprint comprehens approach explor authent bioactiv properti volatil organ metabolit vom present differ spice provid distinct analyt biosignatur relat organolept properti health benefit studi aim establish volatilom fingerprint six consum spice world saffron crocus sativus l cinnamon cinnamomum verum cumin cuminum cyminum l black pepper piper nigrum l sweet paprika capsicum annuum l curri mix differ herb spice base headspac solid phase microextract hs spme follow gas chromatographi mass spectrometri gc ms analysi power strategi explor establish spice volatil pattern unravel potenti health benefit relat import vom identifi spice comprehens knowledg help definit authent simultan protect potenti fraud adulter total vom identifi semi quantit assess reveal terpenoid sesquiterpenoid amount major volatil class investig spice except cinnamon carbonyl compound major group studi spice compris key characterist aroma health bioactiv compound eg dihydrojuneol saffron cinnamaldehyd cinnamon cuminaldehyd cumin curri caryophyllen black pepper princip compon analysi pca partial least squar discrimin analysi pls da success discrimin investig spice cubeben methyl butan patchoulen selinen import vom highest vip contribut discrimin moreov vom high influenc spice bioactiv potenti help prevent certain diseas includ cancer inflammatori relat diseas diabet cardiovascular diseas | D002212;D027622;D028527;D029222;D055549 | T109;T168;T002 |
36,234,939 | function control porous glass produc radic free hyperpolar liquid overhaus dnp overhaus dynam nuclear polar odnp use tool nmr signal enhanc happen short time scale therefor odnp well suit measur fast flow sampl even compact magnet benefici real time monitor chemic reaction process odnp requir presenc unpair electron sampl usual accomplish addit stabl radic howev radic affect nuclear relax time hamper nmr detect circumv immobil radic pack bed allow measur radic free sampl use ex situ dnp techniqu dnp build nmr detect happen differ place flow induc separ hyperpolar liquid radic therefor synthesi robust chemic inert immobil radic matric mandatori present work accomplish immobil radic glycidyloxi tetramethylpiperidinyloxyl polyethyleneimin pei linker surfac control porous glass cpg poros cpgs also size pei linker vari result set distinct radic matric continu flow odnp studi show cpgs pei linker provid robust inert effici odnp matric | D008279;D011094 | T059;T060;T170;T109;T130 |
36,234,938 | mini review molecul induc caspas independ cell death new rout cancer therapi anticanc treatment trigger tumor cell death apoptosi initi proteolyt action caspas protein basic need certain circumst apoptosi prevent apoptosi inhibitor protein survivin hsp sever drug focus classic program death cell report low anti tumorogen potenc due mutat protein involv caspas depend program cell death intrins extrins pathway review concentr role anti cancer drug molecul target altern pathway cancer cell death treatment provid molecular basi new strategi novel anti cancer treatment condit activ agent target altern cell death pathway consid potent chemotherapeut drug mani natur compound small molecul inorgan synthet compound includ sever repurpos drug report caus caspas independ cell death system howev molecul indic caspas depend well caspas free cell death specif cancer line cancer cell altern method caspas independ program cell death equal promis target small molecul small molecul may use lead ration therapeut drug design potenti interest futur cancer prevent strategi | D000970;D009369 | T121;T109;T191 |
36,234,937 | phytochem analysi acacia ehrenbergiana hayn grown qatar identif activ ingredi biolog activ acacia ehrenbergiana hayn also known salam high drought resist shrub distribut north east africa arabian peninsula plant gather gum fiber import legum speci indigen popul studi phytochem analysi antibacteri antioxid properti various alcohol aqueous extract acacia ehrenbergiana grown qatar investig qualit phytochem screen speci exhibit presenc glycosid tannin flavonoid terpenoid saponin phenol anthraquinon various extract agar diffus method perform check antibacteri activ aceton ethanol extract show antibacteri activ control gram negat e coli aceton extract activ bacillus gram posit speci highest activ staphylococcus aureus butanol extract antioxid capac evalu dpph method various extract exhibit antioxid activ similar higher standard antioxid highest percent inhibit aceton ethanol extract aceton extract purifi revers phase combiflash chromatographi follow hplc three pure compound isol subject ms ftir nmr spectral analysi found stigmasterol spinasterol theogallin conclus observ antibacteri antioxid activ well presenc secondari metabolit potenti medicin activ make acacia ehrenbergiana potent valuabl endem medicin plant | D000045;D012503 | T109;T002 |
36,234,935 | torularhodin allevi hepat dyslipidemia inflamm high fat diet induc obes mice via ppar signal pathway torularhodin caroten like compound sporidiobolus pararoseus protect effect high fat diet hfd induc hepat dyslipidemia inflamm investig compar mice cblj fed hfd addit torularhodin hfd hfd signific reduc bodi weight serum triglycerid tg total cholesterol tc low densiti lipoprotein ldl inflammatori mediat tnf il il lipopolysaccharid lps signific increas high densiti lipoprotein cholesterol hdl c benefici cholesterol clearanc also observ hfd group proteom analysi show hdl c c high correl protein eg cpta cypa involv lipid oxid bile acid synthesi wherea phenotyp paramet tc tg ldl inflammatori cytokin high associ protein eg slca involv lipid uptak regul anti inflamm protein fas bax icam ocln gstp faf lrp apex rock manf stat insr regul pro inflammatori protein optn ptkb fadd mif casp yap dnml nampt demonstr occurr hfd induc hepat inflamm also prove anti inflammatori properti torularhodin kegg signal pathway analysi reveal ppar signal pathway like fundament health function torularhodin regul gene relat fatti acid oxid cholesterol excret hdl cc format anti inflamm torularhodin new food resourc may act therapeut agent prevent hepat dyslipidemia relat inflamm improv health | D059305;D050171 | T061;T047;T046 |
36,234,934 | croargoid g eudesman sesquiterpen bark croton argyratus seven new sesquiterpen name croargoid g isol bark croton argyratus compound first exampl eudesman sesquiterpen lacton contain c oh group compound high degrad eudesman sesquiterpen possess rare eleven carbon skeleton structur stereochemistri main elucid nmr analys combin ms ecd data cytotox inhibit isol evalu compound show moder inhibitori activ | D029802;D012717;D045787 | T109;T002 |
36,234,932 | effect heat treatment durat electr properti textur color polymer whey protein research effect heat treatment durat electr properti zeta potenti conduct textur color polymer whey protein pwp analyz whey protein solut heat min obtain singl heat polymer whey protein spwp cool room temperatur process repeat obtain doubl heat polymer whey protein dpwp largest agglomer demonstr min singl heat zeta potenti record mv singl heat decreas conduct next heat cycl heat time increas signific increas firm heat solut zeta potenti polymer whey protein correl firm consist index viscos latter higher zeta potenti r particl size r increas howev correl zeta potenti color research implic futur use pwp dairi industri improv syneret textur sensori properti dairi product | D000081206;D006358 | T079;T070 |
36,234,931 | protect effect orang sweet pepper juic prepar high speed blender low speed mastic juicer uvb induc skin damag skh hairless mice sweet pepper fruit capsicum annuum l contain various nutrient phytochem enhanc human health prevent pathogenesi certain diseas report oral administr orang sweet pepper juic prepar high speed blender low speed mastic juicer reduc uvb induc skin damag skh hairless mice sweet pepper juic reduc uvb induc skin photoag regul gene involv dermal matrix product mainten collagen type matrix metalloproteinas administr sweet pepper juic also restor total collagen level uvb expos mice addit sweet pepper juic downregul express pro inflammatori protein cyclooxygenas interleukin il il il like via inhibit nf b pathway moreov primari antioxid enzym skin enhanc oral supplement sweet pepper juic evidenc increas express catalas glutathion peroxidas superoxid dismutas immunohistochem stain show sweet pepper juic reduc uvb induc dna damag prevent ohdg format result suggest sweet pepper juic may offer protect effect photoag inhibit breakdown dermal matrix inflammatori respons dna damag well enhanc antioxid defens lead overal reduct skin damag | D002212;D015595 | T042;T168;T002;T033 |
36,234,930 | qualiti control oleum cinnamomi assist network pharmacolog strategi oleum cinnamomi tradit medicin use hmong essenti oil obtain fructus cinnamomi treatment coronari heart diseas inform regard effici qualiti control marker lack becom bottleneck restrict develop util integr qualit analysi approach base gc ms network pharmacolog strategi appli explor qualiti control marker assess oleum cinnamomi first compound oleum cinnamomi detect gc ms total chemic compon identifi main monoterpen sesquiterpen account total essenti oil compon second network pharmacolog adopt explor compound link target gene coronari heart diseas fifti two compound found indic effect oleum cinnamomi treatment coronari heart diseas among compound includ eucalyptol chosen potenti effect compound oleum cinnamomi third establish gc ms sim method valid appli simultan determin content compound use sampl batch oleum cinnamomi preliminarili found content compound differ oleum cinnamomi differ origin final quantit analyt data analyz use multivari statist analysi determin oleum cinnamomi qualiti four compound eucalyptol p cymen sabinen pinen identifi chemic marker qualiti control accord studi provid new strategi explor qualiti control marker develop novel method qualiti assess oleum cinnamomi | D003327;D004365;D009822 | T121;T047;T109;T123 |
36,234,929 | antifung agent wood protect review biodegrad wood wood product caus fungi recogn one signific problem worldwid extend servic life wood product wood treat preserv often inorgan compound synthet pesticid negat impact environ therefor develop new environment friend wood preserv carri research center around world search natur plant anim deriv well obtain synthet compound safe human pollut environ time present biolog activ crucial term environment protect review paper present inform literatur substanc chemic compound natur origin plant anim deriv synthet compound low environment impact show antifung properti use research ecolog protect wood review includ literatur report potenti applic various antifung agent includ plant extract alkaloid essenti oil compon propoli extract chitosan ionic liquid silicon compound nanoparticl well combin | D048271;D052578;D009822;D010575;D011429 | T131;T120;T121;T109;T123;T103 |
36,234,928 | cobalt ferrit particl produc sol gel autocombust embed polysilan innov rout magnet induc fluoresc composit fluoresc detect current one common use techniqu worldwid work prepar optic properti interest composit materi discuss shown encapsul cobalt spinel ferrit cofe obtain sol gel autocombust method poli diphenyl co methyl h silan matrix lead fluoromagnet particl psco intrigu optic properti transmiss electron microscopi combin energi dispers x ray analysi show nm larg spheric structur contain core around nm diamet compos magnet ferrit particl surround thin layer semiconduct fluoresc polym obtain materi exhibit ferrimagnet properti ftir spectrum confirm si h function polysilan preserv uv spectroscopi combin molecular model studi indic magnet core strong influenc intramolecular electron transit characterist conjug polysilan analysi steadi state fluoresc spectroscopi reveal intern magnet field strong enhanc polysilan emiss properti investig futur order develop new detect devic | D003035;D012821 | T104;T123;T196 |
36,234,927 | biomed antioxid potenti chilli perspect way forward worldwid sinc age nowaday tradit medicin well known owe biodivers immens contribut advanc develop complementari altern medicin wide rang spice herb tree known medicin use chilli pepper veget cum spice crop bestow natur bioactiv compound flavonoid capsaicinoid phytochem phytonutri pharmacolog activ compound potenti health benefit compound manifest function solo treatment oper synergi consortium co action compound nutrient make potenti effect coagul obes diabet inflamm dread diseas cancer microbi diseas alongsid good anti oxid scaveng abil free radic oxygen recent time capsaicinoid especi capsaicin amelior import viral diseas sar cov addit capsaicin provid abil chilli pepper ramifi topic agent pain relief also benefit man potenti effect anesthet agent phytochem involv make use much econom substitut wonderartifici drug exploit obscen drug product novel stuff respons trpv receptor associ capsaicin mitig chronic diseas also justifi studi nonetheless medicin studi pertain consumpt chilli pepper limit demand confirm find anim studi artifact effort made address access format nutrit biomed perspect chilli pepper could precis upgrad enrich pharmaceut industri toward human well | D000086382;D002212 | T047;T168;T067;T002 |
36,234,926 | synthesi diversifi pyrazolo b pyridin framework aminopyrazol alkynyl aldehyd via switchabl cc bond activ approach cascad endo dig cyclize reaction develop switchabl synthesi halogen non halogen function pyrazolo b pyridin aminopyrazol alkynyl aldehyd via cc bond activ silver iodin nbs addit wide substrat scope reaction show good function group toler well excel region select new protocol manipul three natur product aryl alkynyl alkenyl selen iodin function product reaction demonstr potenti applic new method | D001688;D007455 | T121;T123;T196 |
36,234,925 | applic causal model predict molecular properti textil dye degrad lpmo textil industri one largest water pollut industri world due increas applic chromophor frequent presenc wastewat need ecolog favor dye degrad process emerg predict decolor rate textil dye lytic polysaccharid monooxygenas lpmo develop valid util molecular descriptor structur causal model scm base decis tree algorithm dtm combin mathemat model theori decolor experi elucid import molecular properti dye confirm accuraci scm model result besid potenti util develop model treatment textil dye contain wastewat model good base predict molecular properti molecul import select chromophor reagent determin lpmo activ dye azo triarylmethan group good candid colorimetr lpmo assay determin lpmo activ adequ methodolog lpmo activ determin import step character lpmo properti therefor scmdtm model valid dye molecul power tool select adequ chromophor reagent lpmo activ determin could reduc experiment screen experi | D006899;D062065 | T083;T069;T126;T116 |
36,234,924 | quantif chemic group quantit hplc fingerprint poria coco schw wolf object studi quantit analysi chemic group triterpenoid water solubl polysaccharid acid polysaccharid quantit high liquid perform chromatographi hplc fingerprint poria coco schw wolf pc qualiti control develop amp nbsp methodolog first three main chemic group includ triterpenoid water solubl polysaccharid acid polysaccharid batch pc evalu ultraviolet spectrophotometri afterward quantit fingerprint pc establish alcohol extract pc evalu method involv establish batch pc fingerprint hplc evalu similar differ batch pc identifi eight bioactiv compon includ porico acid b pab dehydrotumulos acid dta porico acid paa polyporen acid c pac epidehydrotumulos acid ea dehydropachym acid dpa dehydrotrametenol acid dta dehydroeburico acid dea pc comparison refer substanc combin quantit analysi multi compon singl marker qam six bioactiv ingredi includ pab dta pac ea dpa dea pc differ place establish addit multivari statist analys princip compon analysi heatmap hierarch cluster analysi intuit visual analysi strategi use evalu content bioactiv compon batch pc final analysi strategi three main chemic group pc combin quantit fingerprint strategi reduc error caus singl method amp nbsp result establish method quantif chemic group quantit hplc fingerprint pc achiev demonstr quantif six triterpen pc singl marker amp nbsp conclus qualit quantit chemic character multi direct simpl effici routin evalu method pc qualiti establish result reveal strategi provid analyt method qualiti evalu pc chines medicin materi | D004365;D055441;D014315;D000070660 | T121;T109;T123;T004 |
36,234,923 | toxic assess binari mixtur aquat organ base differ hypothet descriptor modern industri led creation wide rang organ chemic especi form multicompon mixtur thus make evalu environment pollut difficult normal method paper attempt use forward stepwis multipl linear regress mlr nonlinear radial basi function neural network rbfnn establish quantit structur activ relationship model qsar predict toxic binari mixtur aquat organ use differ hypothet descriptor search proper mixtur descriptor mixtur rule perform test base preliminari model result statist paramet best deriv mlr model n train r rms f q loo q pred train set n test r rms f q ext extern test set rbfnn model gave follow statist result n train r rms f q loo q pred train set n test r rms f q ext extern test set qualiti model assess valid relev paramet final result show develop model predict use toxic predict binari mixtur within applic domain | D059001;D021281 | T001;T081 |
36,234,922 | optim ultrasound oper condit extract quantif fructooligosaccharid garlic allium sativum l via high perform liquid chromatographi refract index detector dietari intervent captur attent nutritionist due health promot aspect addit medic connect supplement nutraceut consid ration approach allevi various metabol disord among novel strategi prebiot supplement food encourag trend address issu present investig prebiot fructooligosaccharid fos extract garlic allium sativum l powder use ultrasound assist extract uae respons surfac methodolog rsm use optim independ sonic variabl ie extract temperatur et c amplitud level al sonic time st min maximum fos yield obtain sonic condit et c al st min minimum yield fos obtain high oper temperatur time optim fos yield obtain et c al st min model valid influenc sonic paramet ie et al st fos yield evalu vari code level respect independ variabl high perform liquid chromatographi refract index detector hplc rid detect quantif indic sucros present high amount g g follow fructos glucos total fos fraction includ nystos present maximum concentr mg g follow kestos mg g fructosylnystos mg g conclus garlic good sourc potenti prebiot fos extract use optim sonic paramet use ultrasound assist techniqu maximum yield percentag | D005737 | T168 |
36,234,921 | biosynthesi dna alkyl antitumor natur product dna alkyl natur product play import role drug develop due signific antitumor activ usual show high affin dna differ mechan aid uniqu scaffold high activ function group therefor biosynthesi natur product extens studi especi construct pharmacophor meanwhil produc strain evolv correspond self resist strategi protect promot function character biosynthet pathway lay foundat discoveri ration design dna alkyl agent summar herein progress research dna alkyl antitumor natur product includ biosynthesi mode action auto resist mechan | D001688 | T121;T123 |
36,234,920 | activ peracet acid cufe rhodamin b degrad activ cu contribut acetylperoxyl radic advanc oxid process aop demonstr great micropollut degrad effici studi cufe success use activ peracet acid paa remov rhodamin b acetyl per oxyl radic domin speci novel system addit hexadien hd methanol meoh signific inhibit degrad effici rhodamin b cu cu redox cycl domin paa activ therebi produc organ radic r includ ch c ch c oo account degrad rhodamin b increas either concentr cufe mgl paa mgl promot remov effici potent system addit weak acid weak alkali ph condit suitabl pollut remov addit humid acid ha hco small amount cl mmoll slight inhibit degrad rhodamin b howev degrad acceler inclus high concentr mmoll cl four iter catalyst recycl degrad effici remain stabl addit function group characterist peak observ take consider reaction condit interf substanc system stabil pollut remov effici cufe paa system demonstr great potenti degrad rhodamin b | D010463;D014874 | T109;T131;T130 |
36,234,919 | high endogen synthes n polyunsatur fatti acid fat mice attenu high fat diet induc insulin resist inhibit nlrp inflammasom activ via aktgsk txnip pathway high fat hf diet low grade chronic inflamm contribut develop insulin resist type diabet td wherea n polyunsatur fatti acid pufa due anti inflammatori effect protect insulin resist interleukin il implic insulin resist yet n pufa modul il secret attenu hf diet induc insulin resist remain elus studi hf diet activ nlrp inflammasom via induc reactiv oxygen speci ros generat promot il product primarili adipos tissu preadipocyt adipocyt induc insulin resist wild type wt mice interest endogen synthes n polyunsatur fatti acid pufa revers process hf diet fed fat transgen mice although hf diet induc higher weight gain fat mice compar control diet mechanist palmit acid pa main satur fatti acid hf diet inactiv ampk led decreas gsk phosphoryl least partial reduc akt activ ultim block nrftrx antioxid pathway induc txnip cytoplasm transloc nlrp inflammasom activ wherea docosahexaeno acid dha abund n pufa fat adipos tissu revers process via induc akt activ gsk shrna knockdown studi reveal gsk play pivot role upstream ampkakt pathway downstream nrftrxtxnip pathway given nlrp inflammasom implic develop inflammatori diseas result suggest potenti n pufa prevent adjuv treatment nlrp inflammasom driven diseas | D003924;D015525;D007333 | T047;T046;T121;T109;T123 |
36,234,918 | green chemic approach iodin pyrimidin deriv mechan grind solvent free condit iodin pyrimidin usual carri use toxic reagent acid condit sulfur acid nitric acid avoid toxic reagent develop simpl eco friend approach iodin pyrimidin deriv solvent free condit use solid iodin agno electrophil iodin reagent advantag method relat short reaction time min simpl set procedur high yield environment friend reaction condit novel approach iodin pyrimidin well varieti deriv contribut develop nucleobas relat drug candid | D054879;D007455 | T068;T121;T123;T196;T070;T067 |
36,234,917 | differ effect quercetin glycosid quercetin kidney mitochondri function uncoupl cytochrom c reduc antioxid activ flavonol found plant aglycon glycosid antioxid activ flavonol may occur via sever mechan within cell mitochondria target may play import role lack inform influenc sugar moieti biolog activ flavonoid glycosid aim studi investig effect quercetin glycosid mitochondri respir rate various metabol state evalu antioxid potenti use chemic biolog approach mitochondri function measur use oxygraph method cytochrom c reduct spectrophotometr h generat mitochondria fluorimetr antioxid activ flavonoid use hplc post column system data reveal quercetin glycosid isoquercitrin rutin hyperosid uncoupl kidney mitochondri respir increas state respir rate signific reduc cytochrom c moreov quercetin glycosid decreas product mitochondri h possess radic scaveng ferric reduc capac highest activ characterist quercetin show sugar moieti signific diminish activ conclus result show effici radic scaveng ferric cytochrom c reduc capac uncoupl properti quercetin glycosid well import sugar residu structur regul kidney mitochondri function | D000975;D011794 | T121;T109;T127;T123;T044;T039 |
36,234,916 | resveratrol maltol resveratrol thiophen hybrid cholinesteras inhibitor antioxid synthesi biomet chelat capabl crystal structur new resveratrol thiophen resveratrol maltol hybrid synthes cholinesteras inhibitor antioxid photost experi biolog test also found remark differ properti behavior thiophen maltol hybrid resveratrol thiophen hybrid excel inhibitori antioxid properti similar activ refer drug galantamin maltol proven weaker inhibitor antioxid molecular dock select activ ligand gave insight structur dock enzym enabl identif interact ligand activ site cholinesteras maltol prove activ cholinesteras inhibitor abl coordin fe ion form complex composit format constant determin spectrophotometri similar lgk suggest fe bind common hydroxi pyranon moieti hard affect aromat part ligand accord characterist band individu absorpt spectra uniform red shift relat free ligand crystal structur two new resveratrol maltol hybrid record give addit inform molecul intermolecular hydrogen bond pack way sever function new resveratrol hybrid examin necessari approach find effect drug complic neurodegen diseas | D000544;D014131 | T047;T121;T123;T196;T048 |
36,234,913 | violin varnish microstructur nanomechan analysi aim current work twofold demonstr applic situ non invas imag portabl atom forc microscopi afm surfac violin integr composit mechan analysi nano scale level model sampl varnish wood sampl prepar accord tradit recip italian lute maker famili well practis art sampl oil spirit base varnish mapl wood natur acceler light age studi afm use measur nanomechan properti model sampl establish spirit base varnish stiffer oil base synchrotron radiat micro fourier transform infra red analysi layer structur reveal stiffer spirit base varnish show less penetr wood oil base peakforc quantit nanomechan map qnm demonstr differ adhes valu oil spirit base sampl | D018625 | T059 |
36,234,912 | molecular dynam structur poli methyl methacryl chain graft barium titan nanoparticl core shell nanocomposit compris barium titan batio bto poli methyl methacryl pmma chain graft surfac vari graft densiti prepar bto nanocryst high k inorgan materi obtain nanocomposit exhibit enhanc dielectr permitt compar neat pmma relat low level loss tangent wide rang frequenc impact molecular dynam structur interact bto surfac polym chain investig nanocomposit character broadband dielectr vibrat spectroscopi ir raman transmiss electron microscopi differenti scan calorimetri nuclear magnet reson presenc ceram nanoparticl core shell composit slow segment dynam pmma chain increas glass transit temperatur concurr increas thermal stabil organ part also evidenc addit segment dynam local relax affect graft densiti influenc self organ interact within pmma phase affect organ smaller size scale polymer chain explain interact expos surfac nanoparticl polym chain | D053758;D019904 | T109;T073;T122 |
36,234,911 | enhanc resist starch content high amylos rice starch heat moistur treatment industri applic object present studi enhanc resist starch rs content high amylos rice starch heat moistur treatment hmt industri applic optim hmt condit achiev highest rs content establish use respons surfac methodolog rsm temperatur c moistur content time h upon hmt rs content increas nativ starch hmt starch optim condit hmt starch reduc solubl swell power surfac hmt starch granul irregular nativ starch x ray diffract xrd peak intens great reduc hmt peak merg hmt increas gelatin temperatur reduc gelatin enthalpi hmt provid method product high yield rs high amylos rice starch industri applic | D000688;D012275 | T109;T168;T002 |
36,234,910 | silico evalu natur flavonoid potenti inhibitor coronavirus diseas recent coronavirus diseas covid outbreak wuhan china led million infect death approxim one million peopl target therapeut current avail effici treatment option access mani research investig activ compound natur plant sourc may inhibit covid prolifer flavonoid general present diet well tradit medicin effect various diseas thus review potenti flavonoid crucial protein involv coronavirus infecti cycl fundament coronavirus structur sar cov mechan entri host bodi also discuss silico studi success employ studi interact flavonoid covid pro spike protein pl pro interact site possibl inhibit recent studi show mani flavonoid hesperidin amentoflavon rutin diosmin apiin mani flavonoid higher affin pro lower bind energi current use drug hydroxylchloroquin nelfinavir ritonavir lopinavir thus compound develop specif therapeut agent covid need vitro vivo studi valid compound pave way drug discoveri | D000086382;D004145;D006569 | T047;T121;T109;T127;T067 |
36,234,909 | current progress chemoenzymat synthesi natur product natur product array structur complex divers biolog activ inspir generat chemist driven advanc techniqu total synthes field natur product synthesi continu evolv develop methodolog improv stereoselect yield scalabl substrat scope late stage function andor enabl novel reaction one interest uniqu techniqu emerg last thirti year use chemoenzymat reaction synthesi natur product review highlight recent exampl progress chemoenzymat synthesi natur product | D001688 | T121;T123 |
36,234,908 | synthesi molecular dock studi cytotox evalu novel thiadiazol well thiazol deriv bear pyridin moieti pyridin thiadiazol thiazol deriv various biolog activ antimicrobi analges anticonvuls antitubercular well anticip biolog properti includ anticanc activ start cyano dimethyl oxopyridin h yl phenylthiourea prepar react various hydrazonoyl halid h haloketon chloropentan dion ethyl chloro oxobutano b afford aryl substitut thiadiazol h phenyl arylthiazol methyl phenyl substitut thiazol b respect structur synthes product confirm spectral data compound also show remark anticanc activ cell line human colon carcinoma htc well hepatocellular carcinoma hepg compar harmin refer vitro condit thiadiazol h found promis excel perform cancer cell line ic respect better refer drug ic respect order check bind mode thiadiazol deriv molecular dock studi perform establish bind site egfr tk | D000970;D013830 | T121;T109 |
36,234,907 | compatibil polylactidepoli ethylen furano plapef blend sustain bioderiv packag despit advantag polylactid pla inadequ uv shield gas barrier properti undermin wide applic flexibl packag film perish item issu address work investig properti melt mix fulli bioderiv blend polylactid pla poli ethylen furano pef function pef weight fraction wt amount commerci compatibilizerchain extend joncryl adr j phr j mitig immisc two polym phase decreas homogen pef domain size blend contain wt pef pef domain size drop uncompatibil blend phr j moreov increas complex viscos pla plapef blend j content evid effect j chain extend dual posit contribut j reflect mechan properti plapef blend wherea uncompatibil blend wt pef show lower mechan perform neat pla compatibil blend show higher tensil strength strain break retain high elast moduli effect pef uv oxygen barrier properti pla also remark ad wt pef make blend excel barrier uv ray transmitt nm drop neat pla sampl wt pef keep good transpar visibl region pef also respons sensibl decreas oxygen transmiss rate decreas ccm day neat pla ccm day wt pef work emphas synergist effect pef j enhanc thermal mechan uv shield gas barrier properti pla result bioderiv blend promis packag applic | D011091;D020959 | T109;T122 |
36,234,906 | la effect surfac anatas methylen blue dye remov dft studi densiti function theori dft wide use method studi matter quantum level studi surfac tio anatas phase consid develop dft calcul explain effect lanthanum ion la electron properti adsorpt capac photocatalyt activ semiconductor due presenc la ion bandgap energi valu latio ev lower obtain tio ev tdos analysi demonstr presenc hybrid level latio compos main p la orbit chemic natur la bond estim pdos analysi bader charg analysi elf function result polar coval type due combin coval ionic bond general adsorpt methylen blue mb molecul surfac latio energet favor surfac tio thermodynam stabil dope tio lanthanum deduc negat heat segment valu obtain evid theoret studi support experiment result report literatur suggest semiconductor latio potenti catalyst applic requir sunlight | D007811;D008751 | T121;T109;T196;T130 |
36,234,905 | high pressur metal free catalyz one pot two compon synthet approach new arylazopyrazolo b pyridin deriv appropri effici q tube assist ammonium acet mediat protocol assembl hitherto unreport arylazopyrazolo b pyridin demonstr methodolog compris cyclocondens reaction amino phenyl h pyrazol one assort arylhydrazon nh oacacoh buffer solut oper q tube reactor versatil protocol exhibit sever outstand merit easi work mild condit scalabl broad substrat scope safeti q tube kit simpli press seal high atom economi consequ perform reaction elev pressur util q tube reactor seem prefer achiev requir product comparison convent condit divers spectroscop method x ray singl crystal techniqu appli confirm propos structur target compound | D011725 | T109 |
36,234,904 | photon trimethin cyanin dye probe biomolecul cyanin dye wide use fluoresc probe biophys medic biochemistri due uniqu photophys photochem properti photon review focus subclass widespread studi cyanin dye trimethin cyanin serv potenti probe biomolecul work devot studi noncoval interact trimethin cyanin dye biomolecul chang properti dye upon interact review addit spectral fluoresc properti elementari photochem properti trimethin cyanin consid includ photoisomer back isomer photoisom generat decay triplet state quench oxygen quencher influenc dna nucleic acid protein biomolecul properti cover interact monom dye molecul biomolecul usual lead fluoresc growth damp photoisomer increas intersystem cross triplet state sometim aggreg dye molecul biomolecul observ quench dye triplet state complex biomolecul molecular oxygen usual occur rate constant much lower diffus limit allow spin statist factor practic applic trimethin cyanin biophys medic biochemistri also consid conclus prospect studi cyanin dye biomolecul system develop new effect dye probe includ probe new type biomolecul discuss | D005456;D011804 | T109;T130 |
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