PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,235,125 | ferment extract naringenin increas express estrogen receptor modul gene relat p signal pathway mir c mir human colon cancer cell expos bpa estrogen receptor beta er protect carcinogenesi stimul apoptosi bisphenol bpa relat promot cancer naringenin chemoprotect activ bind er naringenin colon metabol microbiota cancer involv genet epigenet mechan includ mirna object present studi evalu co exposur effect colon vitro ferment extract naringenin fen bpa elucid molecular effect ht colon cancer cell line quantifi gene relat p signal pathway well er mir c mir import result naringenin ic fen ic promot intrins pathway apoptosi phosphatas tensin homolog pten fold respect casp fold respect express bpa decreas express pten fold gene regul mir suggest co expos cell undergo greater stress forc mediat extrins apoptosi mechan associ death domain fasl turn find relat increas er fold naringenin fold fen gene express import inhibit carcinogen develop | D003110;D035683 | T191;T123;T114 |
36,235,124 | explor nitric oxid releas celecoxib deriv modul radiorespons pheochromocytoma cell cox consid clinic relev molecular target adjuv particular radiosensit treatment regard use select cox inhibitor eg combin radiotherapi endoradiotherapi repres interest treatment option base find nitric oxid releas celecoxib deriv cox inhibitor coxib show promis radiosensit effect vitro herein present develop seri eight novel coxib differ peripher substitut pattern chemic vitro character cox cox inhibit potenc found compar lead coxib releas properti demonstr main influenc substitu posit pyrazol cl vs h introduct n propionamid sulfamoyl residu potenti prodrug strategi lower lipophil mark abolish cox inhibit releas properti mark influenc coxib test vitro combin singl dose extern x ray irradi well lu lucl treatment hif posit mous pheochromocytoma mpc hifa tumor spheroid appli direct x ray irradi lu treatment coxib show radioprotect effect celecoxib use control radiosensit effect observ appli short x ray irradi overal coxib found radioprotect compar celecoxib warrant preclin studi coxib treatment pheochromocytoma howev evalu radioprotect agent healthi tissu could consid coxib develop especi use direct irradi | D000310;D010673;D011355;D011837;D011838 | T191;T120;T039;T121 |
36,235,123 | chemistri potenti antivir anticanc anti inflammatori activ cardioton steroid deriv toad cardioton steroid cts first document ancient egyptian year ago cardioton steroid group steroid hormon circul blood amphibian toad also extract natur product plant herb marin well known cardioton steroid reveal effect congest heart failur atrial fibril therefor term cardioton coin cardioton steroid divid two distinct group cardenolid plant deriv bufadienolid main anim origin cardenolid unsatur five member lacton ring attach steroid nucleus posit bufadienolid doubli unsatur six member lacton ring cancer lead caus mortal human world global cancer load expect million case would increas moreov virus inflamm also nebat impact human health lead mortal current review focus chemistri antivir anti cancer activ cardioton steroid natur deriv toad venom combat chronic devast health problem databas differ research engin googl scholar pubm scienc direct sci finder screen use differ combin follow term cardioton steroid anti inflammatori antivir anticanc toad venom bufadienolid poison chemic composit various cardioton steroid isol divers toad speci exhibit superior anti inflammatori anticanc antivir activ vivo vitro model marinobufagenin gammabufotalin resibufogenin bufalin steroid especi difficult identifi howev sever compound bioactiv identifi use differ molecular biotechnolog techniqu biotechnolog new tool fulli partial generat upscal quantiti natur product otherwis avail trace amount organ | D001688;D002018;D002301;D011042 | T121;T131;T109;T123 |
36,235,122 | synthesi biomed applic high porous metal organ framework review aspect synthesi framework topolog biomed applic high porous metal organ framework discuss term high porous metal organ framework hpmof use denot mof surfac area larger g compound suitabl encapsul varieti larg guest molecul rang organ dye drug protein henc address major contemporari challeng environment biomed field numer synthet approach toward hpmof develop discuss herein attempt made categoris success synthet strategi howev often independ combin differ paramet requir thorough consid synthesi stabl hpmof major hpmof review special interest high poros fascin structur also due capabl encapsul deliv drug protein enzym gene cell henc excel candid biomed applic involv drug deliveri enzym immobilis gene target etc encapsul strategi describ mof categoris accord type biomolecul abl encapsul research field hpmof wit tremend develop recent intrigu featur potenti applic attract research interest promis auspici futur class high porous materi | D000073396 | T109 |
36,235,121 | electrochem properti carbon fiber felt electrochem behavior individu carbon fiber come carbon felt investig use two differ redox coupl dimethanolferrocen potassium ferrocyanid electrochem respons examin differ oxid treatment simul interpret use kissa softwar exist model experi indic crude carbon fiber behav assembl site differ electrochem reactiv case butler volmer law appropri describ electron transfer kinet larg creat overpotenti oxid fiber eras effect increas kinet electron transfer probabl homogen increas reactiv fiber addit analysi signal show larg influenc convect affect electrochem respons even moder scan rate typic v | D002244 | T121;T196 |
36,235,120 | construct non biaryl atropisomer amid scaffold bear c n axi via enantioselect catalysi signific scaffold offer atropisomer amid c n chiral axi extens util pharmaceut agricultur scienc organ synthes result field atropisom synthesi attract consider interest within chemistri communiti date rang catalyt atroposelect approach report effici construct challeng scaffold howev great concis high use methodolog synthesi atropisomer compound focus transit metal chiral amin phosphor acid catalysi reaction etc still desir henc indispens succinct systemat present report mean disclos mechanist analysi applic well challeng issu associ establish atropisom review summar develop catalyt asymmetr synthet strategi access non biaryl atropisom rotat around c n chiral axi includ reaction method mechan late stage transform applic | D000577;D000588 | T109 |
36,235,119 | zeolit adsorb photocatalyst remov dye aqueous environ studi investig potenti zeolit nh beta nh zsm nay remov two frequent use dye methylen blue mb rhodamin b rb aqueous environ remov dye zeolit perform via two mechan adsorpt photocatalysi remov dye adsorpt achiev studi freundlich adsorpt isotherm photocatalyt remov dye perform uv irradi case remov experi conduct min two temperatur k k dye concentr determin spectrophotometr addit photodegrad miner analyz chemic oxygen demand comput analysi structur mb rb perform gain deeper understand obtain result comput analysi encompass densiti function theori dft calcul analysi two quantum molecular descriptor address local reactiv molecul experiment result indic consid zeolit effect remov dye mechan especi nh beta nh zsm due presenc activ acid center outer inner surfac zeolit lowest effici dye remov achiev presenc nay zeolit lower sio al ratio effici reduct complet rb dye agre comput obtain inform reactiv | D014874;D017641 | T131;T197 |
36,235,118 | preliminari structur activ relationship studi mmv pathogen box compound mmv diaminoquinazolin unveil novel inhibitor trypanosoma brucei brucei new drug urgent need treatment human african trypanosomiasi hat line quest novel inhibitor trypanosom small librari analog antitrypanosom hit mmv avail mmv solid materi screen antitrypanosom activ silico explor two potent antitrypanosom structur analog mmv mmv inhibitor dihydrofol reductas dhfr achiev togeth elucid antitrypanosom mode action addit assess vitro tentat inhibit dhfr crude trypanosom extract admet properti also predict use dedic softwar overal two diaminoquinazolin analog display approxim fold fold potenc select vitro parent hit respect mmv ic si mmv ic si analog also strong binder dhfr enzym silico access proton state interact key dhfr ligand recognit residu val asp ile also exhibit signific activ trypanosom protein isol mmv portray fast irrevers trypanosom growth arrest h ic analog induc vitro ferric iron reduct dna fragment apoptosi induct respect two potent analog endow predict suitabl physicochem admet properti good candid deciph potenti start point new drug develop hat | D014344;D014345;D014346;D014353 | T121;T047;T204 |
36,235,117 | engin peptid inhibitor hfe transferrin receptor complex protein hfe homeostat iron regul key regul iron metabol mutat hfe underli frequent form hereditari haemochromatosi hh type studi shown hfe interact transferrin receptor tfr homodimer type ii transmembran glycoprotein respons cellular uptak iron via iron load transferrin holo transferrin bind hypothesis hfetfr interact serv sensor level iron load transferrin circul mean competit mechan hfe iron load transferrin associ tfr investig seri peptid base helic bind interfac hfe tfr generat shown signific interfer hfetfr interact vitro proxim ligat assay helic conform one peptid correspond helic hfe stabilis introduct sidechain lactam stapl result increas abil peptid disrupt hfetfr interact peptid inhibitor protein protein interact hfe tfr potenti use tool analysi function role hfe regul hepcidin express | D006432;D064451 | T047;T123;T116;T125 |
36,235,116 | new triazinoindol bear benzimidazolebenzoxazol hybrid analog potent inhibitor ureas synthesi vitro analysi molecular dock studi twenti four analog base triazinoindol bear benzimidazolebenzoxazol moieti synthes util varieti spectroscop method includ h c nmr hrei ms newli afford compound analyz synthes analog test ureas enzym vitro compar standard thiourea drug triazinoindol base benzimidazolebenzoxazol analog exhibit moder excel inhibit profil ic valu evalu posit control thiourea standard drug better understand structur activ relationship synthes compound split two group b among categori analog analog bear tri hydroxi substitut posit aryl ring c bear di hydroxi substitut posit aryl ring c emerg potent inhibitor ureas enzym display mani time potenc standard thiourea drug besid analog hold di hydroxi substitut posit aryl ring analog bear ortho fluoro substitut show ten fold enhanc inhibitori potenti compar standard thiourea among categori b analog molecular dock studi activ analog categori perform result obtain reveal presenc hydroxi fluoro substitut differ posit aryl ring c play pivot role bind interact activ site target ureas enzym | D001583;D014510 | T109;T126;T116 |
36,235,115 | enhanc cytotox effect arenit combin activ bufadienolid compound human glioblastoma cell line u cytotox trival arsenic deriv arsenit iii combin arenobufagin gamabufotalin evalu human u glioblastoma cell synergist cytotox upregul intracellular arsenic level observ treat iii combin arenobufagin instead gamabufotalin apoptosi activ caspas induc iii strengthen arenobufagin magnitud increas activ caspas much greater caspas suggest intrins pathway play much import role apoptosi increas number necrot cell enhanc ldh leakag intensifi g phase arrest observ remark increas express level hax dna damag marker induc iii arenobufagin concomit activ autophagi observ suggest autophag cell death associ dna damag partial attribut cytotox iii arenobufagin suppress notch signal confirm combin regimen treat cell suggest inactiv jaggednotch signal would probabl contribut synergist cytotox effect iii arenobufagin given iii arenobufagin capabl penetr blood brain barrier find may provid fundament insight clinic applic combin regimen glioblastoma | D000970;D001151;D018053;D002018;D005909 | T131;T121;T191;T109;T196;T104 |
36,235,114 | factor influenc bioavail organ molecul bacteri cell mini review bioavail organ compound bacteri cell crucial vital activ includ compound desir cell eg sourc energi carbon nitrogen nutrient undesir compound toxic cell reason bioavail issu great import mani area human activ relat bacteria eg biotechnolog product bioremedi organ pollut use antibiot articl propos classif factor determin bioavail divid factor physicochem level ie relat solubl chemic compound transport aqueous solut factor microbiolog level ie relat adsorpt cell surfac relat transport cell awar import mechan govern factor describ allow use chang bioavail desir direct | D002244;D004785 | T121;T131;T196 |
36,235,113 | synthesi character newli design high solvatochrom doubl squarain dye sensit select recognit toward cu synthesi character novel zwitterion doubl squarain dye dsq uniqu structur report contrari convent mono bis squarain dye molecular framework report far dsq dye demonstr strong solvatochrom allow multipl ion sens use singl probe judici select suitabl solvent system dsq dye exhibit larg solvatochrom shift nm color chang visibl nir region metal ion sensit util binari solvent consist dimethylformamid acetonitril v v high select detect cu ion linear rang nm detect limit success demonstr result benesi hildebrand job plot analysi reveal dsq cu ion interact molecular stoichiometri appreci good associ constant consid allow limit cu ion intak human bodi recommend propos dye conveni use simpl nake eye colorimetr monitor drink water qualiti | D060766;D005456 | T167;T130 |
36,235,112 | headspac solid phase micro extract versus hydrodistil volatil compound leav cultiv mentha taxa marker safe chemotyp various mint taxa wide cultiv use medicin purpos also cosmet industri applic develop new varieti cultivar mint generat difficulti correct identif safe use volatil organ compound voc leav seven differ taxa genus mentha obtain hydrodistil hd headspac solid phase microextract hs spme analyz use gas chromatographi mass spectrometri gc ms princip compon analysi pca also perform compar gc ms analysi obtain extract show similar major compound pca data allow separ two group chemotyp among analyz mint character abund piperitenon oxid carvon two seven analyz taxa previous examin voc profil one examin patent applic purpos six seven investig first time use hs spme techniqu present analysi provid new data abund qualit character voc studi mint plant safeti use relat possibl presenc potenti toxic compon hs spme valuabl method extend character voc profil obtain hydrodistil | D027541;D055549 | T109;T002 |
36,235,111 | chines cordycep bioactiv compon antitumor effect under mechan review chines cordycep valuabl sourc natur product various therapeut effect rich various activ compon adenosin cordycepin polysaccharid confirm signific immunomodulatori antitumor function howev under antitumor mechan remain poor understood review summar analyz chemic characterist main compon pharmacolog effect mechan immunomodulatori antitumor function analysi reveal chines cordycep promot immun cell antitumor function via upregul immun respons downregul immunosuppress tumor microenviron reset immun cell phenotyp moreov chines cordycep inhibit growth metastasi tumor cell death includ apoptosi autophagi induct cell cycl arrest angiogenesi inhibit recent evid reveal signal pathway mitogen activ protein kinas mapk nuclear factor kappab nf b cystein aspart proteas caspas serinethreonin kinas akt involv antitumor mechan conclus chines cordycep one type magic mushroom potenti develop immunomodul anticanc therapeut agent | D000970;D001688;D032661 | T121;T109;T123;T004 |
36,235,110 | carbazol deriv potenti antimicrobi agent microbi infect lead caus death worldwid result around million death annual due medicin chemist continu search new improv altern combat microbi infect among mani nitrogen contain heterocycl carbazol deriv shown signific biolog activ antimicrobi antifung activ studi review miscellan carbazol deriv antimicrobi activ discuss articl publish | D000890;D000935 | T121;T195 |
36,235,109 | easi fast product solket glycerol acet via heteropolyacid work present effect fast procedur valor main wast produc biodiesel industri ie glycerol acet glycerol aceton repres effect strategi produc valuabl solket fuel addit compon work catalyt effici differ commerci heteropolyacid hpaa compar solvent free system hpas use h pw pw h pmo pmo h siw siw influenc reaction paramet reactant stoichiometri catalyst concentr reaction temperatur investig order optim experiment condit increas cost effici sustain hpas demonstr high effici type reaction present high fast glycerol convers high select solket sustain condit solvent free system room temperatur medium activ hpas use glycerol weight glycerolaceton ratio follow order pw gt pmo gt siw result strong acid site min fact min reaction need achiev solket product presenc pw catalyst last system present effect select sustain catalyt system valor glycerol | D056804;D005990 | T121;T109;T123 |
36,235,108 | research progress posit negat regulatori effect rhein kidney review molecular target current acut kidney injuri aki chronic kidney diseas ckd consid lead public health problem gradual increas incid rate around world rhein monomer compon anthraquinon isol rhubarb tradit chines medicin anti inflamm anti oxid anti apoptosi anti bacteri pharmacolog activ well renal protect effect rhein exert nephroprotect effect main decreas hypoglycem hypolipidem play anti inflammatori antioxid anti fibrot effect regul drug transport howev latest studi show rhein also potenti kidney toxic case larg dosag long use time present review highlight rhein molecular target differ effect kidney base avail literatur clarifi rhein regul function kidney posit negat way help conduct studi make full use rhein kidney avoid kidney damag make effect kidney protect drug | D000975;D051436 | T047;T121;T123;T044;T039 |
36,235,107 | moco carrier bind protein molybdenum cofactor moco activ site prosthet group found numer vital import enzym mo enzym predomin catalyz electron transfer reaction moco synthes evolutionari old high conserv multi step pathway wherebi metal insert reaction ultim reaction step moco intermedi high sensit toward oxid damag consid believ perman protein bound synthesi also moco matur plant cellular moco transfer storag system identifi compris protein capabl moco bind releas possess moco depend enzymat activ first protein describ exhibit properti moco carrier protein mcp green alga chlamydomona reinhardtii howev mcps similar protein meanwhil describ various plant speci review summar current knowledg cellular moco distribut system | D016825;D008667 | T123;T116;T204 |
36,235,106 | screen characterist marin bacillus velezensi z proteas applic enzymat hydrolysi mussel prepar antioxid activ substanc bacillus velezensi type microorgan benefici human anim work proteas produc b velezensi strain z screen sludg sea area near qingdao deposit number cgmcc respons surfac methodolog use analyz proteas product optim temperatur c ph addit nacl result maximum proteas product uml optimum reaction temperatur ph proteas strain z c respect proteas good temperatur ph stabil good stabil solvent methanol ethanol tween ammonium nh mn signific promot enzym activ zn signific inhibit enzym activ proteas produc strain z use enzymolysi mussel meat mussel hydrolys exhibit good antioxid function dpph free radic remov rate hydroxyl free radic remov rate superoxid anion remov rate studi provid refer applic b velez proteas divers process applic mussel meat | D064751;D049872 | T104;T197;T204 |
36,235,105 | occurr characterist staphylococcus aureus strain along product chain raw milk chees poland chees produc unpasteur milk tradit product method may contain mani group microorgan includ staphylococcus aureus aim studi determin occurr aureus artisan chees product chain unpasteur milk investig preval aureus strain isol various stage artisan chees unpasteur milk product farm northeastern southern part poland character character includ antimicrobi suscept microbroth dilut biofilm format vitro assay among strain presenc enterotoxigen gene gene involv biofilm format antibiot resist screen pcr base method total sampl examin high percentag strain resist penicillin tobramycin test isol also show resist macrolid class antibiot azithromycin clarithromycin erythromycin respect among test isol also found phenotyp resist oxacillin cefoxitin bla z gene encod penicillin resist common gene encod antibiot resist among test strain isol show phenotyp resist cefoxitin possess mec gene studi also evalu preval biofilm associ gene eno frequent associ gene eighti nine aureus isol possess least one enterotoxin encod gene result studi show product raw milk chees may sourc antibiot resist virul aureus result suggest artisan chees produc better control product hygien | D002611;D013203 | T047;T168 |
36,235,104 | regioselect synthesi trifluoromethyl triazol via cycloaddit nitril imin cf cn herein describ general approach trifluoromethyl triazol via cycloaddit nitril imin generat situ hydrazonyl chlorid cf cn util trifluoroacetaldehyd aryl oxim precursor trifluoroacetonitril various function group includ alkyl substitut hydrazonyl chlorid toler cycloaddit furthermor gram scale synthesi common downstream transform prove potenti synthet relev develop methodolog | D007097;D009570 | T121;T109 |
36,235,101 | multivari statist analysi mutual depend assess select polyphenol organ acid metal cool climat wine polyphenol organ acid metal ion import group compound affect human health qualiti food beverag product includ wine known specif correl group exist wine come new world old world countri extens studi wine come cool climat countri rare discuss literatur one goal studi determin element composit wine sampl later togeth polyphenol organ acid content use input data chemometr analysi multivari statist approach appli order find specif correl select group compound cool climat wine featur distinguish differ red white wine ros wine moreov special attent paid resveratrol correl select wine constitu | D014920 | T168 |
36,235,100 | free esterifi tocopherol tocotrienol extract non extract tocochromanol relat molecul compendium knowledg futur perspect recommend chromatograph techniqu tool approach use tocochromanol determin free esterifi bound tocopherol tocotrienol tocochromanol relat compound often refer tocol lipophil antioxid great import health instanc tocopherol tocochromanol vitamin e activ tocotrienol posit impact health propos prevent therapi call modern diseas tocopherol tocotrienol plastochromanol well known tocochromanol turn knowledg tocodienol tocomonoenol rare tocochromanol relat compound limit due sever challeng analyt chemistri andor low concentr plant materi presenc free esterifi non extract tocochromanol plant materi well biolog function may great scientif agricultur medicin import also poor studi due lack modern protocol well equip tool instanc techniqu suitabl effici simultan chromatograph separ major minor tocochromanol topic requir attent new solut andor standard proper terminolog review discuss advantag disadvantag differ chromatograph techniqu tool approach use separ detect differ tocochromanol plant materi foodstuff sourc tocochromanol procedur obtain differ tocochromanol analyt standard also describ final futur challeng discuss perspect green techniqu tocochromanol determin propos along best practic recommend present manuscript aim present key aspect protocol relat tocochromanol determin correct identif interpret obtain result | D024508 | T121;T109;T127 |
36,235,099 | investig analysi pesticid residu four common veget risk assess dietari exposur ceram capit china order understand basic situat pesticid residu veget china porcelain capit four kind common veget market select studi detect analysi pesticid residu pesticid residu veget analyz sampl select optim instrument equip condit comparison detect pass rate sampl locat common veget purchas place larg medium size supermarket quecher method use sampl pretreat gas chromatographi gc msms use quantit analysi final exposur risk pesticid assess accord test result result show pesticid detect four kind veget detect pesticid exceed nation standard gb china moreov target risk coeffici thq risk index hi valu four veget less one indic combin toxic effect pesticid residu mix contamin smaller four veget therefor signific harm peopl use veget | D010573;D010575 | T131 |
36,235,098 | new biolog hybrid pharmacophor thiazolidinon base indol deriv synthesi vitro lpha amylas lpha glucosidas along molecular dock investig amylas glucosidas enzym primari harm sourc develop chronic condit known diabet mellitus main function enzym break macromolecul simpl sugar unit direct involv solubl blood henc increas blood glucos level overcom effect need potent effect inhibitor inhibit convers macromolecul sugar smaller unit regard synthes thiazolidinon base indol deriv synthes deriv evalu amylas glucosidas inhibitori activ differ substitut deriv found moder good potenti ic valu rang amylas glucosidas ic among vari substitut compound activ analog four five respect seri show fold better inhibitori activ standard drug acarbos ic respect moreov structur activ relationship sar establish bind interact analyz ligand protein amylas glucosidas molecular dock studi amp nbsp | D005959;D000520 | T121;T126;T116 |
36,235,097 | understand liquid state cyclic hydrocarbon contain n atom via rism kh molecular solvat theori refer interact site model rism molecular solvat theori combin kovalenko hirata kh closur extend seven heterocycl liquid understand liquid state test perform theori solvat free energi sfe calcul solut select solvent comput solvent site distribut profil compar atom molecular dynam md simul show compar perform comput result compar structur paramet liquid whenev avail well experiment sfes liquid found local order structur held togeth via weak interact rism md simul rism kh comput sfes good agreement benchmark valu tetrahydrothiophen dioxid show compar larger deviat case sfes tetrahydrofuran continuum | D006844;D056004 | T066;T109;T044 |
36,235,096 | effici oxid dearomatis substitut phenol use hyperval iodin iii reagent antiprotozo evalu result cyclohexadienon b rhodesiens p falciparum strain nf quinon quinol secondari metabolit higher plant associ mani biolog activ oxid dearomat phenol induc hyperval iodin iii reagent proven use synthet approach prepar compound also wide use organ synthesi medicin chemistri start sever substitut phenol naphthol seri cyclohexadienon naphthoquinon deriv synthes use differ hyperval iodin iii reagent evalu vitro antiprotozo activ antiprotozo activ assess plasmodium falciparum nf trypanosoma brucei rhodesiens stib cytotox compound toward l cell evalu respect select indic si calcul found benzyl naphthoquinon c activ select molecul brucei rhodesiens ic si furthermor antiprotozo assay reveal specif effect addit key physicochem paramet synthesis compound calcul | D000981;D007455;D016778;D009285 | T047;T121;T109;T123;T196 |
36,235,095 | urban grassland plant contribut phytoremedi soil contamin heavi metal main object studi investig whether common wild plant speci urban grassland use phytoremedi soil pollut heavi metal studi conduct citi varadin northern croatia content heavi metal cd cu fe mn ni pb zn determin soil sampl well unwash wash plant sampl taraxacum officinal plantago lanceolata trifolium repen result show pollut site railway station site pollut road traffic soil enrich pb cu zn cd bioconcentr factor three plant speci lt indic relat low capac phytoextract consider amount heavi metal found dust deposit plant surfac confirm statist signific differ wash unwash plant sampl addit biomass plant speci remov tha year mass specif heavi metal remov kgha year requir phytoremedi report conclus phytoremedi common plant speci urban grassland possibl within reason period time | D019216;D012989 | T131;T196 |
36,235,094 | intracellular enzym instruct self assembl peptid ieisap biomed applic despit remark signific encourag breakthrough intracellular enzym instruct self assembl peptid ieisap diseas diagnosi treatment comprehens review focus topic still desir articl care review advanc applic ieisap includ develop various bioimag techniqu fluoresc imag photoacoust imag magnet reson imag positron emiss tomographi imag radiat imag multimod imag success leverag visual cancer tissu cell bacteria enzym activ also summar util ieisap diseas treatment includ anticanc antibacteri antiinflamm applic among other present design action mode structur properti function perform ieisap materi nanofib nanoparticl nanoaggreg hydrogel final conclud outlook toward futur develop ieisap materi biomed applic believ review may foster futur develop ieisap better perform biomed field | D053758;D010455 | T121;T116;T073 |
36,235,093 | biopolym deriv materi supercapacitor recent trend challeng futur prospect supercapacitor may abl store energi maintain fast charg time howev need low cost sophist electrod materi develop innov effect carbon base electrod materi natur occur chemic compon thus critic supercapacitor develop context biopolym deriv porous carbon electrod materi energi storag applic gain consider momentum due wide access high poros cost effect low weight biodegrad environment friendli moreov carbon structur deriv biopolymer materi possess uniqu composit morpholog electrochem properti review aim emphas comprehens concept biopolym supercapacitor approach smart carbon base materi supercapacitor ii synthesi strategi biopolym deriv nanostructur carbon iii recent advanc biopolym deriv nanostructur carbon supercapacitor iv challeng futur prospect viewpoint green chemistri base energi storag studi like use scientif communiti interest design low cost effici green electrod materi supercapacitor well various type electrocatalysi energi product | D002244 | T121;T196 |
36,235,092 | chemic composit antioxid activ cytoprotect silico studi ethanol extract bougainvillea buttiana var orang rose bougainvillea buttiana plant wide use tradit mexican medicin part world treatment various health disord studi antioxid cytoprotect activ three ethanol extract b buttiana bxbo orang bxbr rose bxbr rose investig antioxid activ determin oxygen radic absorb capac orac dpph free radic scaveng activ radic scaveng effect nitric oxid vitro cytoprotect effect extract oxid stress induc hydrogen peroxid h model l cell also determin well uptak without h mtt assay result reveal differ compound present extract hydroxycinnam acid compound observ extract hydroxycinnam acid compound test silico predict biolog passonlin toxicolog osiri properti explor activ extract mgml inhibit activ radic cell expos mgml extract follow h exposur cell protect rang treatment cell extract prevent morpholog chang caus h hydroxycinnam acid compound show probabl silico antioxid cytoprotect activ greater respect therefor result demonstr bxb extract exert antioxid protect activ h induc oxid stress l cell | D032084;D039281;D027826 | T168;T002 |
36,235,091 | assess effect triticonazol soil human health triticonazol fungicid use control diseas numer plant commerci product racem contain r triticonazol residu found veget fruit drink water studi consid effect triticonazol soil microorgan enzym human health take account enantiomer structur applic experiment method appli assess effect triticonazol soil microorgan enzym effect stereoisom soil enzym human health assess use comput approach decreas dehydrogenas phosphatas activ increas ureas activ barley wheat seed treat various dose triticonazol sown chernozem soil least day necessari enzym recov activ consist diminut total number soil microorgan day sow stereoisom abl bind human plasma protein potenti inhibitor human cytochrom reveal cardiotox low endocrin disrupt potenti distinct effect r ttz caus skin sensit carcinogen respiratori toxic signific differ interact energi stereoisom soil enzym ttz expos higher interact energi plasma protein human cytochrom | D060766;D005659;D012989 | T167;T131 |
36,235,090 | christma tree bio wast power sourc bioactiv materi anti prolif activ oral care accord american cancer societi rough new case oral caviti oropharyng cancer detect unit state america caus death main therapi cancer manag surgeri radio chemotherapi benefit albeit often destruct surround tissu thus deep investig non surgic treatment oral caviti need biolog activ compound bac extract european spruce needl analyz determin total phenol flavonoid content use addit ingredi oral hygien product anti prolifer investig carri use extract contain bac use sever cell line cancer normal one esi ms studi bac show luteolin natur flavonoid compound anti tumorigen properti various type tumor predomin compon extract mtt brdu livedead studi demonstr bac extract obtain christma tree needl possess anticanc properti squamous cell carcinoma epitheli origin prove bac extract contain high amount luteolin induc cytotox toward cancer cell along high select robust nontox promis materi oral health applic | D047311;D014197 | T121;T109;T002 |
36,235,089 | semisynthet deriv pentacycl triterpen bear heterocycl moieti therapeut potenti medicin plant use human sinc ancient time treatment various diseas current repres main sourc varieti phytocompound triterpen pentacycl triterpen subject numer studi reveal various biolog activ anticanc antidiabet anti inflammatori antimicrobi hepatoprotect effect employ therapi howev due high lipophil consid exert signific influenc bioavail current use limit frequent approach employ overcom obstacl chemic derivat core structur differ type moieti includ heterocycl consid key element medicin chemistri present review aim summar literatur publish last year regard deriv pentacycl triterpen bear heterocycl moieti focus biolog activ deriv well structur activ relationship predomin target posit derivat triterpen skeleton c hydroxyloxo group c hydroxylcarboxyl group c allyl group extens main scaffold fuse various heterocycl ring phytocompound addit numer deriv also contain linker moieti connect triterpen scaffold heterocycl one linker triazol moieti stand key pharmacophor biolog effect studi support hypothesi triterpenoid conjug heterocycl moieti may repres promis candid futur clinic trial | D009828;D010946;D014315 | T109;T123;T002 |
36,235,088 | current research phytochem medicin non medicin use uncaria gambir roxb review uncaria gambir roxb plant southeast asia wide use altern medicin various applic plant wide use tradit medicin paper aim provid inform u gambir summari data phytochem medic nonmed activ phytochem studi reveal biolog activ constitu flavonoid phenol alkaloid various studi shown extract compound obtain u gambir medic use antioxid antibacteri anti helminth anticanc antifung anti inflammatori anti hyperglycem anti hyperuricem anti lipid peroxid antihyperlipidem properti addit extract use adsorb dye metal ion well corros inhibit thus u gambir common use tradit medicin potenti plant mani therapeut applic prospect drug develop well applic adsorb corros inhibit | D000470;D032070 | T002;T131;T121;T109;T123 |
36,235,087 | corros inhibit effect pyridin thiol brass acid environ studi inhibit perform pyridin thiol ad corros solut investig brass use potentiodynam polar electrochem imped spectroscopi x ray photoelectron spectroscopi electrochem experi perform differ inhibitor concentr h corros medium potentiodynam polar corr valu decreas signific inhibit solut contrast uninhibit solut pyridin thiol optimum inhibit concentr mm give corr valu acm compar acm blank solut ei data indic r p r ct valu increas substanti addit corros inhibitor corros inhibit effici achiev major inhibit solut scan electron microscopi show defect free less scale format inhibit surfac bare brass surfac larger amount scale format x ray photoelectron spectroscopi uv vis spectroscopi use investig surfac chemic composit inhibitor structur chang time | D002424 | T131;T197 |
36,235,086 | role endophyt combat fungal bacteri induc stress plant plant subject multifacet stress signific jeopard crop product pathogen microb influenc biotic stress plant ultim caus annual crop loss worldwid although use pesticid fungicid curb prolifer pathogen plant enhanc crop product pollut environ caus sever health issu human anim henc need altern biocontrol agent offer eco friend mode control plant diseas review discuss fungal bacteri induc stress plant caus various plant diseas role biocontrol defens mechan exampl product hydrolyt enzym secondari metabolit siderophor stress toler fungi bacteria combat plant pathogen observ benefici endophyt could sustain crop product resolv issu regard crop yield caus bacteri fungal pathogen collat literatur review indic futur research necessari identifi potenti biocontrol agent minim util synthet pesticid increas tenabl agricultur product | D060026;D005659 | T131;T004 |
36,235,085 | vitro anticanc screen molecular dock antimicrobi studi triazol base nickel ii metal complex herein describ synthesi seri nickel ii complex c c schiff base hl hl deriv amino mercapto methyl triazol orthometapara nitrobenzaldehyd composit ni l h obtain ligand complex character use physico chemic techniqu viz element analysi magnet moment studi spectral electron ft ir h nmr thermal analysi element analysi spectral analysi reveal schiff base behav monoanion bident ligand toward ni ii ion wherea magnet moment studi suggest octahedr geometri ni ii complex thermal behavior complex studi thermogravimetr analysi agre well composit complex biolog activ antimicrobi antifung studi schiff base ni ii complex screen bacteri speci staphylococcus aureus pseudomona aeruginosa fungal speci aspergillus niger candida albican activ mic method result reveal metal complex exhibit signific antimicrobi activ respect ligand test microbi speci furthermor molecular dock techniqu employ investig activ site select protein inde help us screen potenti anticanc agent among synthes ligand complex compound screen vitro anticanc activ use ovcar cell line result reveal complex activ ligand | D000890;D000970;D056831;D010051 | T121;T104;T109;T191 |
36,235,084 | natur synthet polym scaffold compris upconvers nanoparticl bioimag platform tissu engin modern biocompat materi natur synthet origin combin advanc techniqu process function provid basi tissu engin construct tec effect replac specif bodi defect guid tissu regener describ tec fabric use electrospin print techniqu base synthet polylact co glycol acid plga natur collagen col hyaluron acid ha polym impregn coreshel nayf yb er nayf upconvers nanoparticl ucnp vitro control tissuescaffold interact polymer structur impregn coreshel nayf yb er nayf nanoparticl visual high optic contrast use laser irradi nm found photoluminesc spectra impregn scaffold differ spectrum free ucnp could use control scaffold microenviron polym biodegrad cargo releas prove absenc ucnp impregn scaffold cytotox demonstr high effici cell attach prolifer colon also modifi col base scaffold fabric technolog increas tensil strength structur stabil within live bodi propos approach technolog platform smart scaffold develop fabric base bioresorb polym structur impregn ucnp provid desir photoluminesc biochem mechan properti intravit visual monitor behavior tissuescaffold interact real time | D053758;D023822 | T061;T073 |
36,235,082 | quercetin antioxid mechan antibacteri properti potenti applic prevent control toxipathi quercetin flavonol compound found plant varieti biolog activ wide present natur human diet power oxid properti biolog activ review antioxid mechan broad spectrum antibacteri properti quercetin reveal intervent effect quercetin pesticid poison pathway action investig toxic effect main mycotoxin collect detoxif process quercetin summar whether abl reduc toxic mycotoxin prove harm effect heavi metal poison collect prevent control quercetin evalu review expect enrich understand properti quercetin promot better applic clinic practic | D009183;D010575 | T109;T131 |
36,235,081 | optim microwav assist pectin extract cocoa pod husk optim pectin extract cocoa pod husk carri examin independ variabl affect qualiti pectin obtain determin best condit extract process studi three independ variabl thought contribut microwav assist pectin extract use name extract time min microwav power w citric acid concentr respons surfac methodolog appli use central composit design ccd examin effect independ variabl paramet measur among seven paramet measur name yield temperatur moistur content ash content equival weight methoxyl content galacturon acid content statist analysi test show model equat suitabl predict respons valu temperatur moistur content ash content therefor optim condit review three paramet optim result conclud factor signific effect temperatur moistur content ash content extract time microwav power optim condit pectin extract min extract time w microwav power solvent concentr result temperatur c moistur content ash content paramet valu measur condit yield equival weight mgmol methoxyl content galacturon acid content pectin extract cocoa pod husk use method potenti appli especi food pharmaceut industri | D002099;D010368 | T121;T109;T123;T002 |
36,235,080 | ratiometr fluoresc sensor base dyetb iii function uio high sensit detect tdga thiodiglycol acid tdga biomark monitor vinyl chlorid exposur explor facil rapid precis analysi technolog quantifi tdga great signific research demonstr fluoresc sensor base dual emiss uio tdga detect ratiometr fluoresc materi name c tb uio cooh design synthes introduc organ dye diethylamino methylcoumarin c tb uio cooh obtain c tb uio cooh sampl show high select recognit excel anti interfer rapid respons characterist recognit tdga detect limit mgml much lower threshold mgml healthi person addit mechan tdga induc fluoresc quench discuss detail sensor expect detect tdga content human urin | D014752 | T109;T131 |
36,235,079 | thermorespons dual structur gel emuls stabil glycyrrhiz acid nanofibril combin monoglycerid crystal respons dual structur emuls gel emuls attract attent due complex microstructur demand respons properti control releas activ cargo work effect monoglycerid mg base oil phase structur format stabil structur properti thermorespons cargo releas behavior gel emuls stabil glycyrrhiz acid ga nanofibril investig owe format ga fibrillar network aqueous phase mg crystallin network oil phase stabl dual structur gel emuls success develop microstructur dual structur gel emuls larg depend concentr mg oil phase low mg concentr wt larger form lamellar mg crystal may pierc interfaci fibrillar film induc format partial coalesc droplet contrast high mg concentr wt smaller mg crystal enhanc interfaci activ lead format bilay shell ga nanofibril mg crystal thus effici inhibit interfaci film damag form jam structur homogen distribut small droplet compar pure ga nanofibril gel emuls ga mg dual structur gel emuls show signific improv mechan perform well good thermorespons behavior moreov stabl ga mg gel emuls use food grade deliveri vehicl encapsul protect hydrophob hydrophil bioactiv cargo also great potenti novel effici aroma deliveri system show high control volatil releas dual structur emuls strategi expect broaden applic natur saponin ga base gel emuls food pharmaceut person care industri | D019695;D012503 | T121;T109 |
36,235,078 | introduc linear empir correl predict mass heat capac biomateri studi correl biomass heat capac cp chemistri sulfur ash content crystallin index temperatur various sampl five paramet linear correl predict biomass cp sampl four differ origin absolut averag relat deviat aard proport reduct error ree approv ash sulfur content enlarg correl littl effect accuraci furthermor ree show temperatur effect biomass heat capac stronger crystallin index consequ new three paramet correl util crystallin index temperatur develop model straightforward five paramet correl provid better predict aard propos three paramet correl predict heat capac four differ biomass class residu error jgk literatur relat biomass cp temperatur use quadrat linear correl ignor effect chemistri sampl quadrat linear correl predict biomass cp avail databas aard respect propos model first work incorpor sampl chemistri biomass cp estim | D001672;D006358 | T122;T070 |
36,235,077 | synthesi antifung activ new butenolid contain methoxyacryl scaffold order improv antifung activ new butenolid contain oxim ether moieti seri new butenolid compound contain methoxyacryl scaffold design synthes base previous report structur character h nmr c nmr hr ms spectra x ray diffract analysi vitro antifung activ evalu mycelium growth rate method result show inhibitori activ new compound sclerotinia sclerotiorum signific improv comparison lead compound ec valu v vi sclerotiorum mgl near seven time ec mgl scan electron microscopi sem transmiss electron microscopi tem observ indic compound vi signific impact structur function hyphal cell sclerotiorum mycelium posit control trifloxystrobin molecular simul dock result indic introduct methoxyacryl scaffold benefici improv antifung activ compound sclerotiorum use lead structur optim | D000935;D005659 | T121;T131;T195 |
36,235,076 | develop intellig data analysi approach marin sediment background chemic physicochem properti marin sediment close relat natur anthropogen event real challeng use specif assess indic environment pollut discharg method address studi collect intellig data analysi method cluster analysi princip compon analysi sourc apportion model appli assess qualiti marin sediment identif contribut pollut sourc format total concentr pollut speci studi sediment sampl carri sampl three differ area along coast varna gulf bulgaria perform determin effect pollut chemic descriptor indic toxic metal polyaromat hydrocarbon polychlorin biphenyl nutrient compon humid ignit loss use major goal present studi assess sediment qualiti three differ area along gulf varna bulgaria sourc apportion method result general pattern identifi three type pollut sourc area coastlin vari degre variat zone industri impact zone zone b recreat area zone c anthropogen industri wast conclus quantit apportion procedur made possibl determin contribut identifi pollut sourc zone form total pollut concentr | D019216;D011078;D014874 | T131;T109;T196 |
36,235,073 | biolog efficaci compound stingless honey sting honey two pathogen bacteria vitro silico studi honey inhibit bacteri growth due high sugar concentr hydrogen peroxid generat proteinac compound present studi antibacteri activ stingless sting honey foodborn pathogen bacteria isol spoil milk sampl examin isol bacteri strain confirm bacillus cereus listeria monocytogen morpholog biochem rna analysi physiochem character honey sampl reveal honey sampl acid ph low water content moder reduc sugar content higher prolin content disc diffus method antibacteri activ sampl assay better result observ mgdisc honey stingless sting honey show posit efficaci bacillus cereus therefor silico studi conduct bacterium common compound honey sever retriev constitu stingless sting honey dihydroxi dimethyl h furan one furan h pyran one dihydro sampl beta glucopyranos stingless reveal high ligand protein bind effici target protein dz hemolysin ii root mean squar deviat solvent access surfac area radius gyrat root mean squar fluctuat hydrogen bond use ensur bind stabil dock complex atomist simul confirm stabil combin effort wet dri lab base work support extent antimicrobi properti honey great potenti applic medicin well food industri | D000890;D006722 | T121;T168 |
36,235,072 | sirtuin activ compound discoveri class thiazol base deriv sirtuin sirt nad depend deacetylas implic various biolog patholog process includ cancer diabet cardiovascular diseas recent year sirt activ compound demonstr exert cardioprotect effect therefor enzym becom feasibl target treat cardiovascular diseas mani sirt activ natur synthet origin identifi present work develop thiazol base sirt activ show remark higher sirt activ potenc compar refer compound resveratrol test enzymat assay thiazol repres compound seri also subject pharmacolog investig proven reduc myocardi damag induc vivo occlusionreperfus event thus confirm cardioprotect properti addit cardioprotect effect compound signific higher resveratrol molecular model studi suggest bind mode deriv within sirt presenc p amc peptid promis result could pave way expand optim chemic class new potent sirt activ potenti cardioprotect agent | D002318;D013267 | T047;T109 |
36,235,071 | forens toxicolog aspect misoprostol use pharmacolog abort aim studi establish uhplc qqq msms method deter minat misoprostol acid biolog specimen case pharmacolog abort forens toxicolog examin perform three differ biolog sampl whole blood placenta fetal liver valid paramet method follow limit detect pgml limit quantif pgml coeffici determin gt r intra interday accuraci precis greater recoveri matrix effect rang respect toxicolog analysi mother blood collect two day pregnanc termin reveal abortifaci howev misoprostol acid found placenta pgg fetal liver pgg second case involv fetus found near garbag contain concentr misoprostol acid placenta pgg present studi extens literatur review misoprostol pharmacokinet studi perform knowledg uhplc qqq msms techniqu present paper first quantit method appli forens toxicolog purpos addit postmortem concentr misoprostol acid miscarri fetus due illeg abort report first time | D000019;D000020;D000028;D016595 | T093;T046;T061;T081;T121;T109;T039;T033 |
36,235,070 | amauroderma rugosum extract suppress inflammatori respons tumor necrosi factor alphainterferon gamma induc hacat keratinocyt keratinocyt form physic barrier skin play import role inflammatori process amauroderma rugosum edibl mushroom howev pharmacolog properti seldom studi although anti inflammatori effect organ solvent extract amauroderma rugosum previous report known whether aqueous extract similar effect addit effect amauorderma rugosum extract skin never explor therefor object present studi evalu anti inflammatori effect aqueous extract amauroderma rugosum hacat keratinocyt explor mechan action studi possibl activ ingredi involv result show aqueous extract amauroderm rugosum concentr mgml non toxic hacat cell inhibit releas cytokin interleukin chemokin interleukin monocyt chemoattract protein tumor necrosi factor tnf interferon ifn stimul hacat cell amauroderma rugosum extract reduc intracellular level reactiv oxygen speci addit amauroderma rugosum extract reduc total protein express nuclear factor kappa b nf b b cell inhibitor alpha hacat keratinocyt inhibit phosphoryl mitogen activ protein kinas kinas mek extracellular signal regul kinas erk protein kinas b akt mammalian target rapamycin mtor tnf inf stimul hacat keratinocyt chemic analysi reveal aqueous extract amauroderma rugosum contain polysaccharid triterpen phenol compound anti inflammatori compound gallic acid guanosin uridin also present anti inflammatori effect amauroderma rugosum could mimick combin gallic acid guanosin uridin conclus studi suggest aqueous extract amauroderma rugosum exert anti inflammatori effect keratinocyt antioxid inhibitori effect mekerk aktmtor nf b depend signal pathway | D014315;D014409 | T109;T116;T129 |
36,235,068 | electrochem shell isol nanoparticl enhanc raman spectroscopi imidazol ring function monolay smooth gold electrod imidazol ring im histidin side chain play uniqu role function protein coval bond metal ion hydrogen bond interact adjust biomolecul water biolog interfac interact modifi presenc electr field self assembl monolay sam function im group mimic histidin side chain electrifi interfac studi appli situ shell isol nanoparticl enhanc raman spectroscopi shiner probe structur hydrogen bond im function sam smooth au electrochem interfac self assembl molecul au induc proton shift n atom tautom domin form im bulk sampl n atom tautom ii impact electrod potenti hydrogen bond interact strength im ring identifi shiner temperatur raman measur densiti function theori dft analysi reveal spectral marker im ring pack mode near cm allow us associ confin strong hydrogen bond interfaci im group electrod polar v reflect adsorpt ir rair spectra sam without im reveal bulki ring prevent format strong hydrogen bond amid group network | D006046;D053758 | T121;T196;T073 |
36,235,067 | giant dielectr properti w dope tio ceram effect sinter temperatur dope level concentr microstructur dielectr respons electr properti w dope tio wto prepar via solid state reaction method investig high dens microstructur pure rutil tio homogen dispers dopant element observ ceram sampl mean grain size increas dope concentr sinter temperatur increas presenc oxygen vacanc studi giant dielectr permitt low tan obtain wto ceram sinter c h respons low temperatur improv increas dope level concentr giant respons wto ceram describ interfaci polar interfac semiconduct insul part support imped spectroscopi | D002516;D014025 | T196;T073 |
36,235,065 | innov chiral uplc msms method enantioselect determin dissip soil fenpropidin enantiom chiral piperidin fungicid fenpropidin wide use control plant diseas howev rare studi investig fenpropidin enantiom level studi singl factor analysi combin box behnken design use obtain optim enantio separ paramet fenpropidin enantiom ultra perform liquid chromatographi tandem mass spectrometri absolut configur two fenpropidin enantiom confirm first time use electron circular dichroism optic activ lux cellulos column fenpropidin flow r fenpropidin enantio separ mechan reveal molecular dock modifi quecher method develop trace determin fenpropidin enantiom seven food environment substrat averag recoveri intra day inter day relat standard deviat method success verifi enantioselect dissip fenpropidin soil field r fenpropidin dissip faster fenpropidin half live studi establish brand new effect chiral analysi method fenpropidin enantiom provid basi accur residu monitor risk assess fenpropidin | D005659;D012989 | T131 |
36,235,064 | catalyt deoxygen hydrolyz oil chlorella vulgari microalga lanthanum embed hzsm zeolit catalyst produc bio fuel microalga one import sourc green hydrocarbon contain high percentag lipid like reduc relianc fossil fuel sever zeolit base catalyst short lifetim due coke format deactiv studi lanthanum modifi hzsm zeolit catalyst convers crude oil non oxygen compound hydrocarbon oxygen compound investig crude oil chlorella vulgari microalga extract use soxhlet convert hydrolyz oil ho transesterif reaction experi conduct batch reactor c rpm bar n catalyst algal ho ratio wt h result organ three group product yield chemic composit carbon number distribut liquid product investig includ element composit higher heat valu hhv atom ratio oc hc degre deoxygen dod load lanthanum hzsm zeolit differ load percentag enhanc acid site need algal ho convers among synthes catalyst lahzsm produc highest convers algal ho highest yield hydrocarbon highest hhv highest dod mjkg respect enhanc catalyt convers due presenc lanthanum alter activ site desir reaction catalyt deoxygen main effect modif parent hzsm zeolit lanthanum led adjust acid site need increas convers algal ho catalyt deoxygen process thus increas hydrocarbon yield turn led increas hhv dod propos la base zeolit composit promis differ energi applic due uniqu benefit compar expens less stabl catalyst | D048408;D003077;D058086;D010578;D017641 | T002;T167;T109;T197;T204 |
36,235,062 | effect differ extract method gelatin retrograd properti highland barley starch purpos studi compar gelatin retrograd properti highland barley starch hbs use differ extract method obtain hbs three method includ alkali extract hbs ultrasound extract u hbs enzym extract e hbs investig carri use rapid viscos analyz rva textur profil analysi tpa differenti scan calorimetri dsc x ray diffract xrd fourier transform infrar spectrometri ftir shown differ extract method chang crystallin type hbs e hbs lowest damag starch content highest relat crystallin valu p lt meanwhil hbs highest peak viscos indic best water absorpt p lt moreov e hbs higher g g valu also highest gel hard valu reflect strong gel structur p lt result confirm e hbs provid better past stabil rheolog properti u hbs provid benefit reduc starch retrograd | D001467;D013213 | T002;T121;T109;T123;T168 |
36,235,061 | design synthesi anti varicella zoster antimicrobi activ isoxazolidin yl phosphon conjug n functionalis quinazolin dion dipolar cycloaddit n substitut c diethoxyphosphonyl nitron n allyl n benzylquinazolin dion produc mixtur diastereoisomer diethoxyphosphonyl isoxazolidin n benzylquinazolin dion unit c obtain compound assess antivir antibacteri activ sever compound show moder inhibitori activ vzv ec valu rang mixtur isoxazolidin cis c tran c found activ b cereus pcm show mic valu mgml also mutagen concentr | D006562;D063065 | T047;T109;T131 |
36,235,059 | fulleren perylenediimid c pdi base system overview synthesi versatil platform anchor engin overview differ coval bond synthet strategi two electron acceptor lead fulleren perylenediimid c pdi base system essenti dyad triad present well import applic go develop electron photoact assembl origin aromat platform benzyloxi formylbenzo acid synthes graft pdi dye fulleren c new c pdi dyad exhibit free anchor phenol function could use attach third electro photoact unit studi cascad electron andor energi transfer process obtain unpreced side chain polym c pdi dyad attach pendant moieti onto main polym chain c pdi dyad fulli character cyclic voltammetri show concomit reduct process onto c pdi moieti ident potenti quasi quantit quench fluoresc demonstr c pdi dyad intramolecular energi transfer suggest two unit deprotect benzyloxi group free hydroxyl function group platform use anchor reach new side chain methyl methacryl base polym pdi c dyad unit locat pendant main polym chain polym associ two complementari acceptor could find interest applic optoelectron particular organ solar cell | D037741 | T104 |
36,235,058 | character polyphenol compound bacopa procumben effect wound heal process wound repres medic problem contribut import patient morbid healthcar cost sever patholog hidalgo mexico bacopa procumben plant tradit use wound heal care sever generat vitro vivo experi design evalu effect bioactiv compound obtain b procumben aqueous fraction determin key pathway involv wound regener bioactiv compound character hplcqtof ms prolifer migrat adhes differenti studi conduct niht fibroblast polyphenol compound bacopa procumben pb regul prolifer cell adhes enhanc migrat reduc artifici scratch area modul cell differenti pb compound includ hydrogel topic administr rat excis wound model histolog histochem mechan analys show pb treatment acceler wound closur least h reduc inflamm increas cell prolifer deposit organ collagen earlier time chang result format scar better tensil properti immunohistochemistri rt pcr molecular analys demonstr treatment induc overexpress transform growth factor beta tgf ii phosphoryl smad erk suggest central role pb compound enhanc wound heal modul tgf activ | D034681;D000068377 | T002 |
36,235,056 | lichen extract cetrarioid clade provid neuroprotect hydrogen peroxid induc oxid stress oxid stress involv pathophysiolog mani neurodegen diseas lichen antioxid properti attribut secondari metabolit phenol group studi delv protect capac lichen base antioxid properti action mechan present studi evalu neuroprotect role dactylina arctica nephromopsi stracheyi tuckermannopsi americana vulpicida pinastri methanol extract hydrogen peroxid h oxid stress model neuroblastoma cell line sh syy cell cell pretreat differ concentr lichen extract h h h result show arctica gml n stracheyi gml americana gml v pinastri gml prevent cell death morpholog chang moreov lichen signific inhibit reactiv oxygen speci ros product lipid peroxid increas superoxid dismutas sod catalas cat activ glutathion gsh level furthermor attenu mitochondri membran potenti declin calcium homeostasi disrupt final high perform liquid chromatographi hplc analysi reveal secondari metabolit gyrophor acid lecanor acid artica usnic acid pinastr acid vulpin acid v pinastri alectoron acid americana conclus arctica v pinastri promis lichen prevent treat oxid stress relat neurodegen diseas | D006861;D008011 | T121;T002;T130;T197 |
36,235,055 | ph respons drug deliveri imag studi hybrid mesopor silica nanoparticl system ph respons imag nanocarri develop use mesopor silica nanoparticl msns gadolinium gd dope situ dope gd msn sodium algin sa attach surfac amino group msns nh gd msn electrostat adsorpt amino group carboxyl group format hybrid sa gd msn nanoparticl nps sa coat nps spheric near spheric shape averag size near nm vitro drug releas experi model rhodamin b rhb cargo perform differ ph valu result confirm ph respons nanocarri result cytotox studi indic sa gd msn nps cytotox result vivo safeti evalu hemolysi assay confirm system high biocompat noteworthi contrast system signific enhanc gd indic result mr imag studi confirm synthes hybrid nanosystem promis ph respons drug deliveri mr imag cancer diagnosi treatment | D053758;D012822 | T073;T197 |
36,235,054 | photoluminesc mechan carbon dot trigger multipl color emiss control degre proton carbon dot cds excel optic properti low toxic easi prepar led wide use biomedicin sens optic devic howev although great progress made prepar cds detail explor photoluminesc pl mechan still debat due complex structur surfac function propos singl chang ph synthesi condit effect cds intrins core state avoid mutual influenc multipl pl origin phenylenediamin pd serv carbon sourc whose proton degre determin surfac state result cds accompani fluoresc characterist obtain cds materi appli chemic sensor anti counterfeit field target manner therefor work contribut explan cds pl mechan also obtain seri cds materi control pl properti | D002244;D045663 | T121;T196;T073 |
36,235,052 | discoveri e ligas ligand target protein degrad target protein degrad emerg promis strategi discoveri novel therapeut last decad proteolysi target chimera protac har cellular ubiquitin depend proteolysi system effici degrad protein interest protac consist target protein ligand e ligas ligand enabl target protein degrad owe induc proxim ubiquitin ligas although great number protac develop far use previous report ligand protein degrad e ligas ligand most limit either crbn vhl ligand protac show limit due cell type specif express e ligas recent report resist toward protac crbn ligand vhl ligand overcom hurdl discoveri various e ligas ligand spotlight improv current protac technolog review focus current report e ligas ligand applic develop protac | D025801;D044767 | T126;T123;T116 |
36,235,051 | util novel immunofluoresc instrument prototyp determin herbicid glyphos enzym link fluoresc immunoassay elfia method develop quantit analyt determin herbicid activ ingredi glyphos environment matric surfac water soil plant tissu glyphos ubiquit agricultur pollut xenobiot substanc exposur aquat terrestri ecosystem due extrem high worldwid applic rate immunoassay develop project aquafluosens part fluoresc base instrument setup situ determin sever characterist water qualiti paramet well micropl base competit immunoassay method appli fluoresc signal detect concentr rang ngml glyphos applic fluoresc signal provid limit detect ngml fold lower obtain visual absorb signal besid improv limit detect determin fluoresc provid wider steeper dynam rang glyphos detect matrix effect appear undilut surfac water sampl plant tissu soil sampl requir dilut rate respect cross reaction determin main metabolit glyphos n aminomethylphosphon acid relat compound | D004785;D006540 | T131 |
36,235,050 | qspr model experiment determin antioxid activ polycycl compound radic chain oxid reaction organ substrat present work address quantit structur antioxid activ relationship seri sulfur contain alkylphenol natur phenol chroman betulon betulin acid hydroxyecdyson use gusar softwar statist signific valid model construct predict paramet logk k rate constant oxid chain termin antioxid molecul result use search new potenti effect antioxid virtual librari databas adequ predict logk test sampl combin mna qna descriptor three whole molecul descriptor topolog length topolog volum lipophil use develop six statist signific valid consensus qspr model satisfactori accuraci predict logk train test set structur r tr gt q tr gt r ts gt theoret predict logk antioxid ao ao base consensus model agre well experiment valu measur paper thus descriptor calcul algorithm implement gusar softwar allow us model kinet paramet reaction under liquid phase oxid organ hydrocarbon | D011083;D021281 | T109;T081 |
36,235,049 | essenti role peroxiredoxin iv inflamm cancer peroxiredoxin iv prx cystein peroxidas ubiquit express human tissu prx scaveng hydrogen peroxid particip oxid protein fold endoplasm reticulum addit prx secret outsid cell prx upregul sever cancer potenti therapeut target summar histor recent advanc structur function biolog role prx focus inflammatori diseas cancer oxid stress known activ pro inflammatori pathway chronic inflamm risk factor cancer develop henc redox enzym prx import player crosstalk inflamm cancer understand molecular mechan regul prx express associ signal pathway normal physiolog diseas condit reveal new therapeut strategi thus although prx promis therapeut target inflammatori diseas cancer research need conduct bridg gap clinic applic | D006861;D009369 | T121;T130;T197;T191 |
36,235,048 | imperatorin posit regul melanogenesi signal pathway involv pkacreb erk akt gsk catenin present studi investig melanogen effect imperatorin isoimperatorin under mechan imperatorin use mous melanoma bf model interest treatment either imperatorin isoimperatorin despit structur differ produc differ melanin content intracellular tyrosinas activ imperatorin also activ express melanogen enzym tyrosinas tyr tyrosinas relat protein tyrp tyrp mechanist imperatorin increas melanin synthesi cyclic adenosin monophosph camp depend protein kinas pka camp respons element bind protein creb depend upregul microphthalmia associ transcript factor mitf key transcript factor melanogenesi furthermor imperatorin exert melanogen effect downregul extracellular signal regul kinas erk upregul phosphatidylinositol kinas pik protein kinas b akt glycogen synthesi kinas gsk moreov imperatorin increas content catenin cell cytoplasm nucleus reduc content phosphoryl catenin p catenin final test potenti imperatorin topic applic primari human skin irrit test test perform normal skin upper back volunt determin whether imperatorin irrit sensit potenti test imperatorin induc advers reaction taken togeth find suggest regul melanogenesi imperatorin mediat signal pathway involv pkacreb erk akt gsk catenin imperatorin could prevent pathogenesi pigment diseas use topic agent | D008546;D051739 | T191;T050;T123;T116 |
36,235,047 | identif quantif character phenol fraction brunfelsia grandiflora vitro antioxid capac brunfelsia grandiflora ancient plant wide use promis medicin properti although littl explor scientif despit rich sourc phenol compound respons part proven anti inflammatori activ character carri date present work deal exhaust identif quantif phenol fraction along antioxid activ decoct result bark fine powder filter lyophil polyphenol extract result product aqueous organ solvent seventi nine polyphenol identifi use lc ms n hydroxycinnam abund group compound follow hydroxycoumarin lignan flavonol phenol simpl gallat flavanol flavanon character phenol glycosyl form quantif phytochem lc qtof show medicin plant contain mg phenol compound g dri matter evid great antioxid potenc determin abt dpph assay therefor brunfelsia grandiflora repres import sourc polyphenol support therapeut properti scientif proven | D044950;D017705 | T121;T109 |
36,235,046 | green prepar durian rind base cellulos nanofib applic aerogel studi green high effici low energi consumpt prepar method cellulos nanofib cnf develop use agricultur forestri wast durian rind raw materi power ultrason treatment success reduc w low molecular weight liquid dmso obtain durian rind base cnf diamet nm length sever micromet good dispers stabil water could spontan cross link form hydrogel room temperatur concentr microscop morpholog compress properti cnf aerogel composit cellulos aerogel prepar durian rind base cnf evalu found cnf could effect prevent volum shrinkag aerogel concentr cnf signific effect microstructur mechan properti aerogel cnf aerogel cnf exhibit sheet structur brace fiber strongest compress perform poros cnf aerogel high compress strength composit cellulos aerogel durian rind base cnf effect enhanc | D035161;D057139 | T073;T002 |
36,235,045 | methan product characterist anaerob co digest pig manur ferment liquid feed methan product characterist anaerob co digest pig manur pm ferment liquid feed flf investig continu digest mesophil condit experi follow three phase pm alon digest phase phase ii iii pm flf mix ratio v v respect specif methan yield smys phase ii iii mlch gvs ad respect due effect balanc feedstock carbon nitrogen ratio ad flf improv also attribut readili biodegrad compound flf higher smi obtain studi show posit synergist effect anaerob co digest pm flf result also indic ad flf posit affect maintain constant ph level avoid volatil fatti acid accumul ammonia inhibit anaerob digest ad thus studi provid valuabl inform regard usag unus wast flf co substrat practic ad pm product ferment liquid addit flf improv methan product ad pm potenti novel altern food wast recycl japan besid compost anim feed | D008372;D012037 | T167;T057 |
36,235,044 | monitor shelf life refin veget oil market storag condit kinet chemofoodmetr approach physicochem sensori properti edibl veget oil stabl time one main caus qualiti deplet veget oil oxid influenc sensori accept nutrit valu could even lead toxic compound negat influenc affect intern refin oil price varieti culinari applic model qualiti deplet veget oil establish shelf life general accept time rancid becom evid alreadi remain challeng industri henc paper show promis chemofoodmetr methodolog easi straightforward tool estim current shelf life refin veget oil base comprehens characteris qualiti deplet relat chang storag time real market condit methodolog build multivari kinet age base model describ take account time relat physicochem paramet chemometr process tool particular age state multiparametr model abl reliabl infer expect storag time veget oil remain consist accept requir result studi point accuraci multivari shelf life model regard univari model discrep found oxid rate oil extract differ plant seed | D010938;D012639 | T002;T109;T123;T168 |
36,235,043 | product marin chines lotus root slice use high pressur process altern tradit thermal soak procedur marin veget tradit cold dish long histori special flavor chines deli market howev tradit thermal soak ts procedur often result unreproduc flavor qualiti properti marin veget wast brine time product novel green sustain techniqu high pressur process hpp caught attent food industri studi effect hpp ts treatment visual flavor textur microbiolog qualiti chines marin lotus root slice investig compar ts product lighter color varieti volatil compound crunchier textur detect hpp product throughout c c c shelf life challeng hpp product retain origin color crunchi better ts one wherea signific differ found total viabl count tvcs first half shelf live arrhenius model first order reaction tvc deterior show good fit shelf life hpp marin lotus root slice studi demonstr hpp may assist make best use brine time effici manner improv visual flavor textur qualiti tradit chines marin lotus root slice | D012492;D014675 | T104;T168 |
36,235,042 | detect hydrogen sulfid sewer use erbium dope fiber amplifi diod laser gold plate photoacoust cell photoacoust detect modul base gold plate photoacoust cell report manuscript measur hydrogen sulfid h gas sewer nm distribut feedback dfb diod laser employ excit light sourc photoacoust sensor oper pressur within photoacoust cell laser modul depth optim room temperatur long term stabil photoacoust sensor system analyz allan werl deviat analysi experiment result show atmospher pressur room temperatur condit photoacoust detect modul exhibit sensit vppm h reach minimum detect limit ppb h integr time sensor test field measur sampl gas sewer near shanxi univers canteen level h ppm measur ppm limit report chines sewer bid document | D006862 | T131;T130;T197 |
36,235,041 | experiment examin solubl lipophil pharmaceut relev point novel bioactiv hybrid compound import physicochem properti three novel bioactiv hybrid compound differ group ch f cl studi includ kinet thermodynam solubl pharmaceut relev solvent buffer solut octanol well partit coeffici system octanolbuff ph aqueous solubl chemic poor rang moll compound studi solubl buffer ph simul gastrointestin tract environ order magnitud buffer ph model plasma blood solubl octanol signific higher specif interact compound solvent predict solubl behaviour hybrid compound use hansen three paramet approach show accept result experiment solubl potenti drug success correl mean two common known equat modifi apelblat va nt hoff temperatur depend partit coeffici new hybrid model system octanolbuff ph surrog lipophil measur shake flask method found compound demonstr lipophil natur optim valu partit coeffici oral absorpt bioactiv assay manifest prepar compound show antifung activ equal greater fluconazol addit thermodynam aspect dissolut partit process examin bioactiv assay manifest prepar compound show antifung activ equal greater refer drug | D000935;D015725 | T121;T109;T195 |
36,235,040 | g protein coupl receptor human sperm silico approach identifi potenti modulatori target g protein coupl receptor gpcrs involv sever physiolog process repres largest famili drug target date howev presenc function receptor poor describ human spermatozoa aim identifi character gpcrs present human spermatozoa perform silico analysi understand potenti role sperm function human sperm proteom includ proteom studi criteria use protein identif set lt fdr minimum peptid match per protein cross list gpcrs retriev glass gpcrdb databas total gpcrs identifi human spermatozoa select express male tissu epididymi semin vesicl testi associ male infertil defect mice addit adraa agtr agtr fzd glpr alreadi associ sperm specif function sperm capacit acrosom reaction motil repres potenti target modul improv sperm function final protein protein interact network human sperm gpcrs reveal gpcrs interact protein involv crucial process sperm format matur fertil approach allow identif relev gpcrs adgr adgrl glpr agtr celsr fzd celsr gabbr present human spermatozoa subject investig use even potenti modulatori target treat male infertil develop new non hormon male contracept | D003272;D007248 | T121;T047;T184;T033 |
36,235,039 | clay catalyz ozon hydrotalcit extract lactic acid potenti applic prevent milk ferment inhibit unpreced rout mitig inhibitori effect lactic acid la milk ferment achiev lactat adsorpt hydrotalcit ht simul lactat extract regener ozon ht display catalyt activ appear increas addit montmorillonit mt chang ph zeta potenti catalyst particl size la ozon found strong influenc la la la catalyst catalyst catalyst interact latter determin lactat proton deproton clay dispers aqueous media activ mt appear involv hydrophob adsorpt non dissoci la molecul silica rich area low ph lewi acid base electrostat interact higher ph pka hydrotalcit promot hydrophob interact anion exchang hydrotalcit smectit mixtur found enhanc clay dispers catalyt activ research allow demonstr natur clay miner act adsorb la extract ferment broth catalyst adsorb regener result obtain herein provid valuabl use find envisag seed free milk clot dairi technolog | D001546;D010126 | T121;T103;T197 |
36,235,038 | polysorb versus hydroxypropyl beta cyclodextrin hpcd compar studi excipi stabil stabil benefit monoclon antibodi polysorb ps ps wide use surfact biopharmaceut formul protect protein denatur aggreg surfac adsorpt date around market therapeut antibodi contain either ps ps formul howev polysorb chemic divers mixtur prone degrad oxid hydrolysi produc peroxid fatti acid turn induc protein oxid aggreg insolubl particl format negat impact protein qualiti stabil thus polysorb degrad emerg one major challeng develop commerci therapeut protein product kleptos hpcd hydroxypropyl beta cyclodextrin new multifunct excipi shown provid protein stabil function biopharmaceut downstream process final formul studi aim evalu hpcd new molecul class polysorb stabil biolog formul studi chemic stabil kleptos hpcds compar polysorb various stress condit subject heat stress hpcds show littl chang product recoveri recoveri differ hpcds polysorb show signific degrad undegrad product remain respect subject chemic stressor name autoclav light oxid stress hpcd remain almost stabl polysorb show sever degrad remain polysorb remain polysorb profil character degrad analysi reveal chemic structur hpcds remain intact polysorb undergo signific hydrolyt degrad oxid last physicochem stabil monoclon antibodi formul investig subject light stress adalimumab model mab formul presenc hpcd show signific decreas protein aggreg superior monom total protein recoveri compar ps contain formul hpcd also reduc agit thermal stress induc protein aggreg prevent subvis particl format compar ps | D000074322;D001688;D047392 | T116;T121;T109;T123;T129 |
36,235,037 | panchromat absorb tether bioconjug surfac attach synthes two triad report triad compos two perylen monoimid link porphyrin via ethyn unit bridg perylen posit porphyrin posit triad also contain singl tether compos alkyno acid isophthal unit triad provid panchromat absorpt nm fluoresc emiss near infrar region nm fluoresc quantum yield synthes reli prepar tran ab porphyrin bear one site tether attach aryl group b two open meso posit ab porphyrin prepar condens diformyldipyrromethan dipyrromethan instal two perylen monoimid group achiev upon dibromin porphyrin subsequ copper free sonogashira coupl accomplish attach tether synthes provid relat straightforward access panchromat absorb use bioconjug surfac attach process | D010569;D011166 | T123;T109;T131;T130 |
36,235,036 | jnd new type ii trk inhibitor overcom trk xdfg mutat resist vitro vivo tropomyosin receptor kinas trks valid effect target anticanc drug discoveri two first generat trk inhibitor approv market display encourag therapeut respons cancer patient harbor trk fusion protein howev acquir resist mediat secondari trk mutat especi xdfg motif remain unsolv challeng clinic herein report preclin pharmacolog result jnd new type ii pan trk inhibitor overcom trk mutant resist includ xdfg mutat vitro vivo low nanomolar level jnd display strong activ wild type trkabc secondari mutat involv xdfg motif substitut kinas assay cellular model occupi trk protein extend time slower dissoci rate trk inhibitor moreov intraperiton inject jnd exhibit tumor growth inhibit tgi dose mgkg baf cd trka gc mice xenograft model therefor jnd consid lead compound drug discoveri overcom resist trk inhibitor drug mediat xdfg mutat | D000970;D009369 | T121;T109;T191 |
36,235,035 | tradit health chemic bioactiv character five tradit plant sever scientif studi prove bioactiv effect mani aromat medicin plant associ presenc high number bioactiv compound name phenol compound antioxid anti inflammatori antimicrobi capac molecul arous high interest industri sector includ food pharmaceut cosmet work aim determin phenol profil infus hydroethanol extract five plant carpobrotus eduli genista tridentata verbascum sinuatum cytisus multiflorus calluna vulgari employ mani tradit prepar addit antioxid antimicrobi anti inflammatori anti tumor activ differ prepar evalu use vitro assay hplc dad esim profil reveal presenc eighti phenol compound belong seven differ famili compound regard antioxid properti hydroethanol extract c eduli show potent effect tbar assay ic gml g tridentata hydroethanol extract achiev better result oxhlia test ic gml cytotox anti inflammatori result v sinuatum infus stood signific gi gml ic gml respect final c eduli hydroethanol extract display relev antibacteri activ show mbc valu mgml g tridentata hydroethanol extract exert greatest antifung effect mfc mgml result studi deepen knowledg phenol profil also provid evid bioactiv properti speci select could consid high valuabl option research applic sever sector name food cosmet pharmaceut | D000975;D010936 | T121;T044;T123;T039 |
36,235,034 | barium titan function organosilan effect particl compat permitt nanocomposit barium titan bt recent gain new interest prepar dielectr piezoelectr lead free materi applic sensor electron energi harvest storag field barium titan nanocomposit achiev attract perform provid compat ceram particl polymer matric enhanc benefit physic properti final composit tune particl matrix interfac particl function repres viabl solut work surfac function bt nanoparticl nps obtain hydrotherm synthesi glycidyloxypropyltrimethoxysilan acetoxi polyethyleneoxi propyl triethoxysilan triethoxysilylpropoxi polyethyleneoxi dodecano perform optim hydroxyl process nps improv surfac reactiv increas yield graft solid state nuclear magnet reson thermogravimetr analysi use quantifi molecul graft onto ceram nanoparticl bare function particl employ realize epoxi polydimethylsiloxan pdms base nanocomposit function proven benefici particl dispers effect particl align pdms matrix moreov dielectr constant measur reveal potenti pdms base nanocomposit applic field dielectr elastom | D053761;D017646 | T109;T073 |
36,235,033 | redox trigger switch conform state tripl decker lanthanid phthalocyanin doubl tripl decker lanthanid phthalocyanin exhibit uniqu physic chemic properti particular singl molecul magnet among factor magnet properti sandwich depend conform state determin via skew angl phthalocyanin ligand thus present work report comprehens conform studi substitut terbium iii yttrium iii trisphthalocyanin solut depend substitu peripheri molecul redox state natur solvent conjunct uv vis nir spectroscopi quantum chemic calcul within simplifi time depend dft tamm dancoff approxim provid spectroscop signatur stagger gauch conform trisphthalocyanin altogeth allow us demonstr butoxi substitut complex behav molecular switcher control conform state crown substitut tripl decker complex maintain stagger conform regardless extern factor analysi noncoval interact within reduc densiti gradient approach allow shed light natur factor stabil certain conform | D028581 | T196 |
36,235,032 | saccorhiza polyschid sourc natur activ ingredi greener skincar formul grow knowledg harm effect caus synthet ingredi present skincar product led extens search natur bioactiv thus studi aim investig dermatolog potenti five fraction f f obtain sequenti extract procedur brown seawe saccorhiza polyschid antioxid dpph frap orac tpc anti enzymat collagenas elastas hyaluronidas tyrosinas antimicrobi staphylococcus epidermidi cutibacterium acn malassezia furfur anti inflammatori nitric oxid tumor necrosi factor interleukin interleukin photoprotect reactiv oxygen speci properti fraction evalu ethyl acet fraction f display highest antioxid photoprotect capac reduc ros level uvab expos fibroblast highest anti enzymat capac tyrosinas ic valu gml solid water insolubl fraction f reveal greatest antimicrobi activ c acn growth ic valu gml furthermor fraction demonstr anti inflammatori potenti reduc tnf il level raw macrophag induc lipopolysaccharid chemic analysi polyschid fraction nmr reveal presenc differ class compound includ lipid polyphenol sugar result highlight potenti polyschid incorpor new natur base skincar product | D000890;D000459 | T121;T204 |
36,235,031 | multinuclear mri drug discoveri continu develop magnet reson imag broaden rang applic newer area use mri visual also track pharmaceut substanc label cell vivo vitro test h wide use mri method determin high content human bodi potenti mri method make excel tool imag morpholog examin object also enabl registr chang level metabol sever report scientif public use clinic mri vitro track use multinuclear mri great potenti scientif research clinic studi tune mri scanner larmor frequenc given nucleus allow imag without tissu background heavi nuclei compon drug contrast agent molecular complex implement hyperpolar techniqu allow better mri sensit aim review present use multinuclear mri investig drug deliveri | D003287;D008279 | T059;T060;T170;T130 |
36,235,030 | post function organometal complex via click reaction cuaac cu catalyz azid alkyn cycloaddit click reaction simpl power method post synthet modif organometal complex transit metal approach allow select introduct addit donor site function group peripheri ligand environ especi import metalloligand free donor site natur primari site coordin primari metal creat concept post synthet modif organometal complex click reaction relat recent current avail experiment materi yet allow us identifi trend formul recommend address specif problem present studi appli cuaac reaction post synthet modif diimin mononuclear complex pt ii ir iii cc bond peripheri ligand environ demonstr click chemistri power tool tunabl chemic post synthet modif coordin compound | D001386;D057930 | T070;T104;T062 |
36,235,029 | synthesi dock studi pharmacolog evalu serotoninerg ligand contain norbornen carboxamid nucleus new seri norbornen carboxamid deriv prepar affin ht ht ht c receptor evalu compar previous synthes seri deriv character exo n hydroxi norbornen dicarboximidenucleus order identifi select ligand mention subtyp receptor arylpiperazin repres one import class ht r ligand recent research concern new deriv focus modif one portion pharmacophor combin structur element heterocycl nucleus propyl chain substitut piperazin known critic affin ht receptor proper select substitu led compound high specif affin toward serotoninerg receptor activ compound select vivo assay determin function activ final ration obtain result molecular dock studi perform result pharmacolog studi show norbo norbo activ promis deriv serotonin receptor consid studi | D011985;D012701 | T109;T123;T116;T192 |
36,235,028 | c spinosa l subsp rupestri phytochem profil effect oxid stress normal cancer cell spice wide use improv sensori characterist food contain sever bioactiv compound well includ polyphenol carotenoid glucosynol act multipl pathway bioactiv molecul affect wide varieti cellular process involv molecular mechan import onset progress human diseas cappari spinosa l aromat plant characterist mediterranean diet previous studi report differ part aerial part root seed c spinosa exert various pharmacolog activ flower bud c spinosa contain sever bioactiv compound includ polyphenol glucosinol two differ subspeci c spinosa l name c spinosa l subsp spinosa c spinosa l subsp rupestri report studi carri c spinosa l subsp rupestri aim studi investig phytochem profil floral bud less investig speci c spinosa subsp rupestri moreov investig effect extract bud c spinosa subsp rupestri cse cell prolifer intracellular ros level express antioxid anti apoptot enzym paraoxonas pon normal cancer cell cell caco cell select model advanc stage human bladder cancer human colorect adenocarcinoma respect immort human urotheli cell line urotsa human dermal fibroblast hude chosen normal cell model untarget metabolom approach base ultra high perform liquid chromatographi quadrupol time flight mass spectrometri uhplc qtof ms result demonstr c spinosa subsp rupestri flower bud contain polyphenol glucosinol abl exert higher cytotox effect higher intracellular reactiv oxygen speci ros product cancer cell compar normal cell moreov upregul express enzym pon observ cancer cell conclus data demonstr normal cancer cell differenti sensit cse differ effect pon gene express well overexpress pon cell treat cse could repres mechan tumor cell protect apoptot process induc glucosinol polyphenol | D031484;D009369 | T191;T168;T002 |
36,235,027 | pllan ii induc cell death cervic cancer squamous epitheli cell via unfold protein accumul endoplasm reticulum stress due lack chemotherapeut drug select affect cervic cancer cell natur sourc snake venom current investig molecul antitumor potenti pllan ii phospholipas type asp porthidium lansbergii lansbergii snake venom induc cell death cervic cancer cell line ca ski relat dysfunct abil resolv endoplasm reticulum stress evidenc sub express gene perk ero pdis hsp chop western blot analysi valid last two gene sub express protein level addit pllan ii present dose depend cytotox effect cancer cell insignific effect healthi endotheli cell huvec addit pllan ii inhibit cancer cell adhes migrat capac induc cell cycl arrest gm phase induc apoptosi stimul possibl extrins rout result demonstr first time pllan ii antitumor effect squamous epitheli cervic cancer cell line repres possibl biotechnolog tool design promin antitumor agent | D000970;D001859;D001943;D002294;D002583 | T121;T109;T191 |
36,235,026 | effect hydrophil polym releas rate pharmacokinet acyclovir tablet obtain wet granul vitro vivo assay studi aim evalu feasibl produc acyclovir contain modifi releas matrix tablet wet granul method base type concentr two pharmaceut grade hydrophil matrix polym ie hydroxypropyl methylcellulos hpmc carbom combin common use biomed applic mechan properti tablet vitro vivo perform studi physicochem properti raw materi correspond physic mixtur character differenti scan calorimetri show hydrophil polym influenc physicochem properti drug wet granul process improv flow compress properti obtain granul method enabl prepar matrix tablet acyclovir appropri mechan properti concern hard friabil drug releas kinet govern type concentr hydrophil polym compos matric studi proven hpmc compos tablet superior modifi drug releas properti compar carbom hpmccarbom base tablet mathemat analysi releas profil determin medium adjust ph follow ph reveal drug releas hydrophil tablet follow non fickian first order kinet optim hpmc base formul submit acceler stabil studi c rh stabl three month complet cross bioavail studi select acyclovir load sustain releas tablet market immedi releas tablet compar six healthi male volunt extent drug absorpt sustain releas tablet signific greater immedi releas pill may improv drug antivir properti attribut lower elimin rate enhanc acyclovir half life | D005079;D011108 | T104;T120;T122 |
36,235,025 | antioxid antimicrobi activ thai edibl plant extract prepar use differ extract techniqu studi investig antioxid antimicrobi activ six thai edibl plant leaf extract includ cashew cn chamuang cm monpu mp thurianthet tt kradon kd pakliang pl extract use ethanol extract ee microwav assist extract mae ultrason assist extract uae leaf extract character percentag yield total phenol content tpc total flavonoid content tfc diphenyl picrylhydrazyl dpph ferric reduc antioxid power frap activ antimicrobi activ spoilag mae produc highest percentag yield among mae extract mp exhibit highest yield furthermor highest tpc tfc obtain mae mae extract kd cn show highest tpc tfc respect among sampl highest dpph frap valu seen mae process cn kd mp extract inhibit zone pathogen bacteria minimum inhibitori concentr minimum bacteri concentr determin sampl except tt find indic compar ee uae mae improv antioxid antimicrobi efficaci leaf extract aforement extract could employ natur food addit prevent chemic microbi spoilag food | D000975;D010945 | T121;T123;T168;T044;T039 |
36,235,024 | allogen bone impregn biodegrad depot deliveri system local treatment joint replac infect vitro studi although progress evid effect treatment joint replac relat infect still remain serious issu orthoped exampl local applic antibiot impregn bone graft suppli high drug level without system side effect howev antibiot powder solut form could risk local toxic allow sustain drug releas present studi evalu use antibiot gel water oil emuls plga microparticul solid dispers depot deliveri system impregn bone graft treatment joint replac relat infect result rheolog bioadhes test reveal suitabl formul impregn bone graft moreov negat effect prolifer viabil bone marrow mesenchym stem cell detect ex vivo dissolut test vancomycin hydrochlorid gentamicin sulphat impregn bone graft show reduc burst prolong drug releas plga base formul prove particular promis one day burst releas drug follow sustain antibiot releas zero order kinet result studi basi develop new product tissu section univers hospit treatment bone defect infect joint replac | D019643;D018380 | T061 |
36,235,023 | metallo drug cancer therapi past present futur cancer treatment includ convent chemotherapi proven success cure human malign failur treatment modal includ inher resist system toxic sever side effect patient administr chemotherapi surviv reason identif new drug design therapeut strategi could target cancer cell leav normal cell unaffect still continu challeng despit advanc led develop new therapi treatment option still limit mani type cancer review provid overview platinum copper ruthenium metal base anticanc drug clinic trial vitroin vivo studi presum copper ruthenium complex greater potenti pt ii complex show reduc toxic new mechan action differ spectrum activ possibl non cross resist focus discuss toward past present futur aspect | D000970;D056831;D009369;D012428 | T121;T191;T109;T196;T104 |
36,235,022 | binuclear triphenylantimoni v catechol n donor linker structur featur redox properti seri binuclear triphenylantimoni v bis catecholato complex type cat ph sb linker sbph cat prepar reaction correspond mononuclear catechol cat sbph neutral bident donor linker ligand pyrazin pyr dipyridyl bipi bis pyridin yl disulfid pysspi diazobicyclo octan dabco dri toluen cat di tert butyl catechol dbcat linker pyr pysspi bipi dabco cat di tert butyl catechol dbcat linker bipi dabco cat piperazin diyl di tert butylcatechol pip dbcat linker bipi dabco cat dichloro di tert butylcatechol cl dbcat linker bipi dabco cat dimethoxi di tert butylcatechol meo dbcat linker bipi reaction cl dbcat sbph dabco open atmospher result format coordin polym cl dbcat sbph h dabco n bis catechol complex ph sb cat spiro cat sbph react bipi yield rare macrocycl tetranuclear compound ph sb cat spiro cat sbph bipi molecular structur crystal state establish singl crystal x ray analysi complex demonstr differ type relat spatial posit mononuclear moieti natur chemic bond charg distribut energi sb n interact investig exampl complex electrochem behavior complex depend coordin n donor ligand coordin pyrazin bipi pysspi antimoni atom chang mechan electrooxid instead two success redox stage catsq sqcat one multielectron stage observ coordin dabco ligand accompani signific shift oxid potenti catechol ligand cathod region v compar initi complex | D000965;D009795 | T131;T109;T196 |
36,235,021 | involv arsenic atom asf five pnicogen bond differ x ray structur theoret model bond within asf crystal analyz via quantum chemic method identifi quantifi pnicogen bond present structur finit crystal segment contain nine molecul compar fulli optim cluster size geometri qualit differ much larger bind energi within optim nonam although total interact energi central unit remain peripher molecul compar two structur bind peripher one anoth far larger optim cluster distinct much stronger total bind within optim cluster limit nonam repeat smaller aggreg well averag bind energi cluster rise quick size asymptot approach valu near tripl dimer | D001151;D010758 | T121;T131;T196;T197 |
36,235,019 | essenti oil composit tradit use salvia dentata poor known medicin plant namaqualand south africa south africa rich histori medicin plant speci document use tradit medicin also home three well known blue flower sage speci ethnobotan import namaqualand bloublomsali salvia dentata far remain unstudi appar overlook studi first report essenti oil chemistri medicin relev speci provid comparison two well studi close relat cape bloublomsali salvia africana chamelaeagnea data generat three geograph isol popul compris individu plant dentata reveal diagnost high level camphor pinen camphen cineol eucalyptol bornyl acet provid distinct chemic profil two speci | D009822;D010946;D027544 | T109;T002 |
36,235,018 | simpl enzym immobil flow chemistri assess avail strategi acetaldehyd depend aldolas enzym immobil technolog enabl bio catalyst appli continu flow system howev plethora immobil method avail individu advantag disadvantag assess influenc simpl readili avail method respect perform deoxi ribos phosphat aldolas dera continu flow condit investig immobil strategi cover unspecif attach carrier via epoxid affin base attach via metal ion affin streptag streptactin interact well coval affin attach enzym matrix tether halotag metal ion affin base approach outperform method term immobil activ stabil appli condit enzym examin today alreadi histag purif purpos effect immobil may appli simpl standard purif need | D000079;D005634 | T109;T126;T116 |
36,235,017 | high effici biomass compound aerosol suppress purifi radioact cesium droplet aerosol nuclear accid decommiss nuclear industri would releas larg number radioact aerosol endang natur environ health worker therefor urgent need environ friend aerosol suppress control handl environment pollut problem caus radioact aerosol paper sodium algin sa type polyphenol materi tp alkyl glycosid apg select compon compound aerosol suppress optim proport generat via method optim mixtur design furthermor cesium aerosol sediment effect optim compound aerosol suppress evalu via sediment effici chang particl concentr cumul concentr fraction cesium aerosol sediment process result show aerosol sediment effici much higher natur settlement water spray sediment moreov spray compound suppress display good effect settl cesium aerosol particl diamet less concentr particl reduc final sediment mechan compound aerosol suppress cesium aerosol particl coagul effect analyz use particl size distribut | D002586;D059808 | T121;T109;T196 |
36,235,015 | hydrotherm method generat carbon quantum dot wast bone detect laundri powder surfact one major pollut laundri powder impact environ human health carbon quantum dot cqds spheric zero dimension fluoresc nanoparticl great potenti fluoresc probe electrochem biosens ion sens herein bottom approach develop synthesi cqds biomass detect laundri deterg laundri powder wast chicken bone use carbon precursor dri crush react pure water c h generat cqds exhibit monodispers quasi spheric structur averag particl size nm function group includ oh co cc c identifi surfac prepar cqds optim fluoresc excit wavelength yellow brown cqds nm correspond emiss peak nm cqds signific increas cell death multipl cell line concentr gml fluoresc enhanc cqds observ addit sodium dodecyl benzen sulphon major anion surfact laundri powder linear relationship fluoresc enhanc cqds concentr laundri powder establish thus hydrotherm method develop generat cqds wast biomass may use fluoresc probe detect laundri powder | D004785;D045663 | T131;T073 |
36,235,014 | transcriptom metabolom analys provid insight flavonoid accumul peel citrus reticulata chachi qualiti chines medicin materi depend content bioactiv compon affect environment factor differ plant region research integr analysi transcriptom metabolom c reticulata chachi perform two region three orchard includ analysi total compound found fresh peel among differenti accumul flavonoid metabolit flavonoid enrich peel xinhui plant region total gene regul peel xinhui includ chs gst gene involv salt stress respons overal base correl analysi flavonoid content gene express peel c reticulata chachi conclud authent gcrp xinhui may close relat higher content naringin narirutin increas content may due high salin environ xinhui region | D002957 | T168;T002 |
36,235,013 | chemic composit antioxid antiprolif activ taraxacum officinal essenti oil taraxacum officinal histor use medicin purpos due biolog activ specif disord investig antioxid antiproliferativepotenti essenti oil vitro vivo chemic composit essenti oil analyz gc ms vivo antioxid capac assess liver kidney homogen sampl mice subject acetaminophen induc oxid stress treat essenti oil mgkg bw day vitro scaveng activ assay use diphenyl picrylhydrazyl dpph reduc power method cytotox effect hela cancer cell line analyz gc ms analysi show presenc compound identifi major constitu essenti oil protect mice liver kidney acetaminophen induc oxid stress enhanc antioxid enzym catalas superoxid dismutas glutathion lower malondialdehyd level vitro essenti oil demonstr low scaveng activ dpph ic mgml modest reduc power ec mgml growth hela cell also reduc essenti oil inhibit rate gml current result reveal signific antioxid antiprolif effect dose depend manner suggest taraxacum officinal essenti oil could use formul cancer therapi | D009822;D031205 | T109;T002 |
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