PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
|---|---|---|---|
36,234,793 | biolog activ copaiba damag alveolar bone model periodont induc rat sever studi investig effect natur product treatment diseas tradit amazonian popul common use copaiba due well known anti inflammatori antibacteri heal properti studi aim investig effect system administr copaiba oleoresin copaifera reticulata duck ligatur induc periodont rat adult rat divid three group n control group ligatur induc periodont group ligatur induc periodont group treat copaiba oleoresin mgkgday ligatur remain day copaiba oleoresin administ via oral gavag last seven day day anim euthan mandibl collect histopatholog evalu microcomput tomographi analysi data show administr copaiba consider reduc inflammatori profil moreov copaiba oleoresin limit alveolar bone loss increas trabecular thick bone tissu volum ratio decreas number trabecula compar untreat experiment periodont group find provid pioneer evid support potenti copaiba oleoresin reduc periodont induc alveolar bone damag rat | D016301;D007887;D010518 | T047;T002 |
36,234,792 | object supervis machin learn base classif infer biolog neuron network classif biolog neuron type network pose challeng full understand human brain organis function paper develop novel object classif model biolog neuron morpholog electr type network base attribut neuron communic use supervis machin learn solut present advantag compar exist approach neuroinformat sinc data relat mutual inform delay neuron obtain spike train abund convent morpholog data construct two open access comput platform various neuron circuit blue brain project realist model name neurpi neurgen investig could perform network tomographi cortic neuron circuit morpholog topolog electr classif neuron extract simul data network topolog combin five layer morpholog type type cell electr type e type cell appli data sever differ classifi includ support vector machin svm decis tree random forest artifici neural network achiev accuraci infer biolog network structur use network tomographi reach accuraci object classif biolog network achiev cascad machin learn method use neuron communic data svm method seem perform better amongst use techniqu research contribut exist classif effort set road map futur usag brain machin interfac toward vivo object classif neuron sens mechan brain structur | D016571;D000069553 | T170;T066 |
36,234,790 | cis lobelin tran lobelin studi pharmacodynam isomer factor lobelin alkaloid deriv leav indian tobacco plant lobelia inflata prepar chemic synthesi classifi partial nicotin agonist long histori therapeut usag rang emet respiratori stimul tobacco smoke cessat agent presenc cis tran isom lobelin well known mani studi relationship structur pharmacolog activ lobelin analog report howev remark fact studi report differ pharmacolog activ two isom articl found differ degre isomer lobelin inject signific differ respiratori excitatori effect pentobarbit sodium anesthet rat compar cis lobelin inject respiratori excitatori effect signific reduc administr inject contain tran lobelin studi influenc factor isomer two isom shown isomer one way isomer convert cis tran temperatur catalyt factor ph key factor studi report new discoveri despit widespread use ventil first aid medicin nikethamid lobelin retir second line nonselect antagonist high affin ab ab nicotin acetylcholin receptor nachr recent year lobelin shown great promis therapeut drug mental addict nervous system disord depress alzheim diseas parkinson diseas therefor suggest differ two isom concern subsequ research paper applic | D000470;D029746;D009552;D011978;D019141 | T116;T002;T192;T131;T121;T109;T123 |
36,234,789 | integr luminesc porous aromat framework indic paper facil rapid select detect nitro compound porous aromat framework materi high stabil sensit select great potenti provid new sensor optoelectronicfluoresc probe devic work luminesc porous aromat framework materi lnu synthes via palladium catalyz suzuki cross coupl reaction tetrabromopyren bisphenyldibor pinacol ester result paf solid exhibit strong fluoresc emiss quantum yield show excel light heat stabil lowest unoccupi molecular orbit lumo lnu higher nitro compound energi transfer excit lnu analyt lead select fluoresc quench limit detect lod integr luminesc paf powder paper simpl dip method indic paper reveal fast fluoresc respons gaseous nitrobenzen within show great potenti outdoor fluoresc detect nitro compound | D009574;D010165 | T109;T196 |
36,234,788 | discoveri novel c jun n termin kinas inhibitor natur product integr artifici intellig structur base virtual screen biolog evalu c jun n termin kinas jnk current consid critic therapeut target type diabet recent year great interest naturopath molecul discoveri activ ingredi natur product specif target receiv increas attent base background research aim combin emerg artifici intellig technolog tradit comput aid drug design method find natur product jnk inhibitori activ first construct three machin learn model support vector machin random forest artifici neural network perform model fusion base vote stack strategi integr model better perform auc respect employ virtual screen natur product zinc databas drug like filter calcul bind free energi screen compound use molecular dock perform consensus analysi two methodolog subsequ identifi three promis candid lariciresinol tricin demethylepipodophyllotoxin accord obtain probabl valu relev report bind characterist preliminarili explor molecular dynam simul final perform vitro biolog valid three compound result show tricin exhibit accept inhibitori activ jnk ic natur product use templat molecul design novel jnk inhibitor | D001688 | T121;T123 |
36,234,787 | electr cell substrat imped sens eci conveni tool assess potenti low molecular fraction deriv medicin fungus cerrena unicolor action l ct cell line increas incid cancer contribut search new therapeut method recent year use prepar natur origin medic fungi increas one activ substanc extracellular low molecular activ fraction obtain medicin fungus cerrena unicolor studi aim monitor pharmacokinet differ concentr substanc isol medicin fungus cerrena unicolor ex lms use eci techniqu studi mous l fibroblast colon cancer ct cell line treat differ concentr activ fraction obtain cerrena unicolor c gml c gml c gml studi demonstr test prepar cerrena unicolor consider effect resist capacit imped l fibroblast cell indic signific effect physiolog process time paramet exhibit decreas colon cancer cell viabil follow previous current studi cerrena unicolor ex lms extract safe use anticanc therapi chemoprevent signific harm effect normal cell | D003110;D020072 | T191;T004 |
36,234,786 | composit studi phospholipid dri big head opossum shrimp mussel sea cucumb use p nmr spectroscopi content fatti acid composit plasmalogen herein present qualit quantit analysi composit plasmalogen phospholipid pls dri big head shrimp solenocera melantho opossum shrimp neomysi awatschensi mussel mytilus galloprovinciali sea cucumb apostichopus japonicus also analyz fatti acid composit extract lipid phosphatidyl cholin ptdcho plasmalogen cholin plscho sampl big head shrimp opossum shrimp mussel phosphatidyl cholin ptdcho abund pl mg g dri sampl respect wherea abund pl sea cucumb plscho mg g dri sampl four sampl plasmalogen ethanolamin plsetn higher phosphatidyl ethanolamin ptdetn content mg g dri sampl plscho highest mussel higher big head shrimp opossum shrimp sea cucumb content mg g dri sampl plsetn order mussel gt big head shrimp gt opossum shrimp gt sea cucumb analyz fatti acid sn posit plscho consecut treatment phospholipas solid phase extract thin layer chromatographi tlc gc fid appli abund fatti acid eicosapentaeno acid epa c n big head shrimp sea cucumb palmitol acid c n opossum shrimp docosadieno acid c n mussel | D049872;D012616 | T204 |
36,234,785 | inhibit morc mediat hdac promot cellular senesc pp signal axi background colorect cancer crc common gastrointestin malign account second largest gastrointestin tumor morc newli discov chromatin remodel protein play import role biolog process various cancer howev potenti mechanist role morc promot prolifer crc carcinoma remain unclear method cancer genom atlas databas analyz use bioinformat obtain gene express clinic prognosi data cell prolifer assess cck edu assay well xenograft sa beta gal stain western blot elisa assay use assess cell senesc potenti mechan result data show morc express elev crc patient deplet morc inhibit cellular prolifer vivo vitro studi show deplet morc enhanc p p express decreas hdac increas pro inflammatori factor il il thus promot cellular senesc conclus conclud increas morc express crc might play critic role tumorigenesi regul cellular senesc addit morc could novel biomark clinic outcom prognosi treatment target crc | D015850;D016159 | T123;T116;T129 |
36,234,784 | ration design fluoresc chromophor calcium receptor via dft multivari approach comput experiment approach adopt util chromophor diglycol function fluorescein deriv ca receptor fluorescein diglycol acid fl dga synthes use multivari determin ca k full structur comput show complex ca compar energi regardless addit interact lacton moieti initi format diglycol ca complex follow macrocycl thermodynam disfavor u shape pre organ allow ca interact simultan diglycol lacton motif motif activ particip ca recognit eleven methylen unit undecyl arm provid excel flexibl reorgan optimum interact princip compon analysi pca comput molecular properti reveal simpl method evalu motif cation recognit fragment model support full structur result negat charg caus signific structur chang reproduc full extent c bond break observ latter experiment optic respons show select toward ca discrimin k mg pca emiss intens afford distinct cluster mm ca k suggest applic techniqu simultan determin cation plant macronutri precis agricultur wide varieti applic | D002118;D044169 | T116;T192;T121;T123;T196 |
36,234,783 | valoris lignocellulos wast case studi eucalypt stump lignin bioadsorb remov cr vi main object work assess eucalyptus globulus lignin adsorb compar result kraft lignin previous demonstr effect adsorb eucalypt lignin extract dioxan techniqu characteris adsorpt properti cr vi ion evalu monomer composit type lignin indic high content guaiacyl g syringyl unit low content p hydroxyphenyl h h g ratio eucalypt lignin kraft lignin determin py gcms accord element analysi sulphur sodium found kraft lignin eucalypt lignin adsorpt capac eucalypt lignin notabl higher kraft lignin first h practic ion absorb eucalypt kraft lignin h respect cr vi adsorpt onto lignin fit well use langmuir adsorpt isotherm model capac mgg respect eucalypt kraft studi overal result demonstr great potenti eucalypt lignin biosorb cr vi remov aqueous solut | D002857;D014874 | T131;T196 |
36,234,782 | pollut exposur risk biogen amin can sea fish classif analyt method base carbon sphere quecher extract combin hplc studi investig pollut characterist exposur level health risk assess seven kind biogen amin bas eight varieti can sea fish product n chines market carbon sphere quecher mix dispers solid phase extract combin hplc use classif analysi batch sampl averag recoveri singl bas obtain method relat standard deviat differ varieti sampl differ degre pollut mass concentr singl bas rang mgkg total concentr bas rang mgkg concentr bas rang mgkg composit four bas main putrescin cadaverin histamin tyramin alway play import role exposur level risk assess sampl exposur level bas human bodi rang gkg health risk assess show gender trend exposur risk level bas male gt femal young age femal gt male middl old age age trend young age gt old age gt middl age region trend citi gt countrysid food safeti index bas sampl far less risk within control rang | D006632;D011700 | T121;T109;T123 |
36,234,781 | densiti function method studi cooper intermolecular h bond stack interact thymin c n mim br n microhydr explor ionic liquid mechan action nucleobas structur properti still limit work bind model alkyl methylimidazolium bromid c n mim br n ionic liquid thymin studi water environ pcm microhydr surround pcm w h geometri mono di tri tetra ionic thymin w h c n mim x br w x complex optim x g p level ir uv vis spectra qtaim nbo analysi stabl h br h c n mim br h c n mim br h c n mim br hydrat present great detail result show order arrang stabil thymin cation c n mim pcm stack gt perpendicular gt coplanar anion br front gt top stabil order differ microhydr follow h lt h br lt h c n mim br lt h c n mim br lt h c n mim br good linear relationship bind e b valu increas number x ion found indic cooper interact h bond stack vari increment grow ionic cluster stack model thymin c n mim cation accompani weaker hydrogen bond alway much less favor x br complex trend hold cluster size grow length alkyl chain imidazolium cation increas qtaim nbo analyt method support exist mutual reinforc hydrogen bond cooper system | D052578 | T103;T120 |
36,234,780 | intersystem cross methlypyrazin studi femtosecond photoelectron imag methylpyrazin excit high vibrat dynam state nm femtosecond laser light evolut excit state probe nm light unstabl state decay via intersystem cross triplet state may decay ground state via intern convers intersystem cross observ combin time resolv mass spectrometri time resolv photoelectron spectroscopi crossov time scale ps rydberg state identifi photoelectron spectral angular distribut indic accident reson state p rydberg state respect ionize | D011789;D014732 | T170;T070 |
36,234,779 | evalu anti cancer potenti rosa damascena mill callus extract human colorect adenocarcinoma cell line chemotherapi aggress form chemic drug therapi aim destroy cancer cell adjuv therapi may reduc hazard chemotherapi help destroy cell obtain natur product medic plant studi potenti therapeut effect rosa damascena callus crude extract produc vitamin enhanc media investig colorect cancer cell line caco two elicitor ie l ascorb acid citric acid concentr gl ad callus induct medium callus extract gc ms analysi methanol crude extract also determin cytotox clonogen prolifer migrat caco colorect cancer cell investig use mtt cytotox coloni form ki flow cytometri prolifer migrat scratch assay respect result indic l ascorb acid treatment enhanc callus growth paramet improv secondari metabolit content show least ic valu ugml compar ugml ugml citric acid treat control group conclud r damascena callus elicit l ascorb acid improv growth secondari metabolit content well effici antiprolif anti clonogen anti migratori effect caco cancer cell thus use adjuv anti cancer therapi | D000230;D015179;D027826 | T191;T002 |
36,234,778 | glycosyl format glycosyl neighbor group particip protect benzyol glycosyl format synthes one step correspond orthoest use formic acid sole reagent glucopyranosyl mannopyranosyl galactopyranosyl donor synthes glycosyl properti studi use model glycosyl acceptor vari steric bulk reactiv bismuth triflat prefer catalyst kpf use addit tran select result neighbor group particip excel glycosyl general high yield | D005561 | T109 |
36,234,777 | thermodynam properti crystallin cellulos allomorph studi dispers correct densiti function method phonon properti thermodynam four crystallin cellulos allomorph ii iii investig use dispers correct densiti function theori dft line experiment find free energi differ studi cellulos allomorph small less kjmol per atom calcul specif heat constant volum cv compar avail experiment data temperatur rang k quasiharmon approxim employ studi thermodynam specif heat constant pressur cp studi temperatur rang k specif heat cellulos allomorph show similar behavior calcul experiment specif heat agre well low temperatur k deviat theori experi increas temperatur may due increas phonon anharmon temperatur increas | D002482 | T109;T123;T122 |
36,234,776 | character triadica sebifera l small extract antifeed activ extract fraction seed oil isol compound plutella xylostella l effect detoxif enzym plutella xylostella l one world major pest crucifer crop indiscrimin use synthet insecticid led insecticid resist resurg harm non target organ environ botan insecticid best altern synthet pesticid manag pest organ agricultur integr manag sebifera invas speci good potenti insecticid due avail plant materi part india antifeed activ sebifera report p xylostella lepidopteron insect date therefor current studi target character leaf bark extract feed deterr synergist detoxif enzym activ leafbark ethanol extractsfract seed oil isol compound uhplc qtof im analysi show shikim acid xanthoxylin quercetin kaempferol methyl gallat stigmasterol common metabolit identifi leaf bark extract combin seed oil bark extract show higher deterr dc mgl compar leafbark extract alon gallic acid show higher deterr kaempferol quercetin n butanol fraction bark repel rc mgl base dc seed oil leaf extract ratio alon choic seed oil leaf bark extract without choic show synergist interact seed oil bark extract choic show addit interact ethanol extract leaf bark seed oil inhibit gst ach p xylostella leaf extract seed oil combin may recommend antifeed reduc damag p xylostella base persist antifeed phytotox safeti predatorsparasitoid etc field condit | D019665;D007306;D009036 | T131;T002;T204 |
36,234,774 | design synthesi biolog evalu novel dihydropyridin pyridin analog potent human tissu nonspecif alkalin phosphatas inhibitor anticanc activ ros dna damag induc apoptosi small molecul nitrogen contain scaffold gain much attent due biolog import develop new anticanc agent present paper report synthesi librari new dihydropyridin pyridin analog divers pharmacophor compound test human tissu nonspecif alkalin phosphatas h tnap enzym compound show excel enzym inhibit h tnap ic valu rang multi fold higher standard inhibitor levamisol h tnap enzym furthermor mtt assay carri evalu cytotox hela mcf cancer cell line among analog potent dihydropyridin base compound select investig pro apoptot behavior analysi demonstr compound play signific role induc apoptosi multipl mechan includ overproduct reactiv oxygen speci mitochondri dysfunct dna damag arrest cell cycl g phase inhibit cdk apoptosi induc effect compound studi stain agent microscop flow cytometri techniqu detail structur activ relationship sar molecular dock studi carri identifi core structur featur respons inhibit enzymat activ h tnap enzym moreov fluoresc emiss studi corrobor bind interact compound dna fluoresc titrat experi | D000970;D004095 | T121;T109 |
36,234,773 | akebia saponin inhibit inflammatori reaction inhibit il stat dnmtb axi activ nrf pathway akebia saponin asd deriv dipsacus asper wall ex henri tradit chines medicin common use treat rheumat arthriti ra howev depth mechan anti inflammatori effect asd still unclear studi aim preliminarili explor anti inflammatori effect asd under mechan perspect dna methyl inflamm relat pathway found asd signific reduc product multipl inflammatori mediat includ nitric oxid prostaglandin e pge lps induc raw cell express dna methyltransferas dnmt b induc nitric oxid synthas ino also obvious inhibit asd treatment protein mrna level interleukin il tumor necrosi factor tnf also signific inhibit asd asd inhibit macrophag phenotyp inhibit high level dnmtb downregul signal transduc activ transcript stat pathway exert anti inflammatori activ furthermor dnmtb sirna nrf sirna signific promot anti inflammatori effect asd studi demonstr first time asd inhibit il stat dnmtb axi activ nuclear factor e relat factor nrf signal pathway achiev inhibitori effect inflammatori reaction | D015850;D051267 | T123;T116;T129 |
36,234,772 | fate sulfonamid tetracyclin meat pan cook focus thermodegrad sulfamethoxazol although antimicrobi general found trace amount meat human health risk bear ignor ultim aim make better assess consum exposur studi explor effect pan cook sulfonamid tetracyclin meat screen antimicrobi cook meat first perform european union refer laboratori basi hplc msms analys proof concept approach use radiolabel carri cook sensit antimicrobi sulfamethoxazol assess thermal degrad could explain observ cook loss degrad product detect thank separ hplc monitor onlin radioact detect hplc orbitrap hrms analys complet nmr experi allow structur character degrad compound studi reveal cook could induc signific antimicrobi loss sulfamethoxazol six potenti degrad product c sulfamethoxazol detect cook meat thermal degrad pattern propos studi highlight import consid cook step chemic risk assess procedur impact level chemic contamin meat format potenti toxic breakdown compound | D006571;D013754 | T104;T109 |
36,234,771 | marker independ food identif enabl comb machin learn algorithm comprehens gc gctof ms reliabl method alway great desir practic food inspect current food inspect techniqu main depend identif special compon neglect combin effect differ compon often lead bias result use chines liquor exampl develop new food identif method base combin machin learn gc gctof ms sampl prepar method spme lle compar optim produc repeat high qualiti data two machin learn algorithm tri support vector machin svm algorithm final chosen better perform shown method perform well identifi geograph origin flavor type chines liquor high accuraci respect also reason propos combin machin learn advanc chromatographi could use food complex compon | D000465;D000069550 | T170;T066 |
36,234,770 | homocoupl sodium arenesulfin select access symmetr diaryl sulfid diaryl disulfid symmetr diaryl sulfid diaryl disulfid effici select construct via homocoupl sodium arenesulfin select product reli differ reaction system symmetr diaryl sulfid predomin obtain pd oac catalysi wherea symmetr diaryl sulfid exclus yield presenc reduct fehcl system | D004220;D013440 | T104;T109 |
36,234,769 | methylazanedyl bis methylen bis dimethylphenol induc autophag associ cell death mtor mediat autophagi lung cancer autophagi multistep mechan elimin damag organell misfold protein mechan preced may induc program cell death apoptosi studi unravel potenti pharmacolog effect md induc autophagi lung cancer cell result show md concomit autophagi induct indic autophagosom stain induct atg atg ubiquitin protein p express h treatment lc strong convers lc ii p downregul h treatment apoptosi induc activ found h treatment indic annexin v fitcpropidium iodid stain activ caspas mechanist perspect h treatment md substanti downregul p mtor meanwhil p pik p akt also suppress md concentr respect confirm tor mediat autophag activ compar effect md rapamycin potent standard mtor inhibitor western blot immunofluoresc assay although md could suppress p mtor much rapamycin combin rapamycin md could increas mtor suppress activ lc activ chang substitu group r group dimethylphenol ethylphenol emd chang methylazanedyl cyclohexylazanedyl cd could induc apoptosi activ autophag induc activ identifi md novel compound target autophag cell death affect mtor mediat autophagi | D000080549;D008175 | T191;T043 |
36,234,768 | role regul thromboxan signal cancer trojan hors misdirect last two decad increas awar role eicosanoid develop progress sever type cancer includ breast prostat lung colorect cancer sever process involv cancer develop cell growth migrat angiogenesi regul arachidon acid deriv thromboxan txa higher level circul txa observ patient multipl cancer accompani overexpress txa synthas tbxas txa andor txa receptor tbxar tp overexpress txa tp tumor cell general associ poor prognosi reduc surviv metastat diseas howev role txa signal stroma oncogenesi underappreci txa signal regul tumor microenviron modul angiogen potenti tumor ecm stiff host immun respons moreov product txa high mutagen oncogen ad overal phenotyp txa synthesi promot tumor format various level stabil synthet enzym receptor pathway cancer mutat report suggest txa signal viabl target adjunct therapi various tumor reduc immun evas primari tumor growth metastasi | D009369;D013930 | T191;T126;T116 |
36,234,767 | develop applic opto chemic tool zebrafish zebrafish one wide adopt anim model basic translat research popular zebrafish result sever advantag high degre similar human genom eas genet chemic perturb extern fertil high fecund transpar fast develop embryo relat low cost effect mainten particular bodi transluc uniqu featur zebrafish adequ obtain vertebr organ anim distinct optic clariti small size therefor make success model optic modul observ furthermor conveni microinject high embryon permeabl readili allow effici deliveri larg small molecul live anim final numer number sibl obtain singl pair anim offer larg replic improv statist analysi result review describ develop opto chemic tool base various strategi control biolog activ unpreced spatiotempor resolut also discuss report applic tool zebrafish highlight current challeng futur possibl opto chemic approach particular singl cell level | D015027 | T013 |
36,234,766 | folic acid antimetabolit antifol brief review synthet strategi applic opportun antimetabolit folic acid repres larg group drug drug candid includ cancer chemotherapi current review common method approach present synthesi therapeut signific antimetabolit folic acid methotrex mtx raltitrex tomudex zd pralatrex pemetrex tnp lometrexol addit applic use folic acid antimetabolit also discuss | D005493 | T121 |
36,234,765 | porous structur inspir lignocellulos biosorb medulla tetrapanaci effici adsorpt cation dye focus work develop green low cost effici biosorb base biolog structur properti mt appli remedi cation dye dye wastewat adsorpt perform mechan mt methylen blue mb crystal violet cv investig batch adsorpt experi result demonstr highest adsorpt valu mt mb mgg cv mgg great higher report valu biosorb addit adsorpt behavior methylen blue mb crystal violet cv mt spontan exotherm reaction close follow pseudo second order pso kinet langmuir isotherm deplet mt regener use pyrolysi mode convert deplet mt mt biochar mbc maximum adsorpt cu pb mbc mgg mgg respect conclus work present new option adsorpt cation dye wastewat new perspect treatment deplet biosorb | D004396;D014874 | T109;T131;T130;T197 |
36,234,764 | isol mirificin bioactiv isoflavon glycosid kudzu root lyophilis use centrifug partit flash chromatograph techniqu pueraria lobata willd ohwi legum taxon nativ southeast asia wide use tradit medicin system region therapeut applic underground part speci known kudzu root relat high content isoflavon main characterist c glycosid deriv within group explor compound phytochem pharmacolog puerarin howev current scientif find document import anti biodegen effect minor isoflavon kudzu root therefor main object studi develop origin prepar method allow effici isol close relat hydrophil daidzein c glycosid includ mirificin vacuum dri aqueous ethanol extract kudzu root purpos combin centrifug partit cpc flash chromatograph fc techniqu elabor use optim biphas solvent system cpc ethyl acet ethanol water vv acet acid mobil phase modifi enabl purif separ polar fraction contain bioactiv isoflavon ultim isol mirificin hydroxi methoxypuerarin puerarin daidzin use fc ident isoflavon confirm use spectroscop uv absorpt nuclear magnet reson mass spectrometr method determin puriti isol mirificin | D007529;D029908 | T121;T109;T002 |
36,234,763 | ionize decamethylmanganocen insight dft assist laser spectroscopi metallocen repres one import class organometal wide prospect practic use various field chemistri materi scienc molecular electron biomedicin mani applic metal complex base abil form molecular ion report first result concern chang molecular electron structur decamethylmanganocen cp mn upon ionize provid high resolut mass analyz threshold ionize mati spectroscopi support dft calcul precis ionize energi cp mn determin ev dft model mati spectrum show main structur deform accompani detach electron consist elong mn c bond chang plane bend angl surpris dft calcul predict reduct electron densiti ed upon ionize associ hydrogen atom substitu despit metal charact ioniz orbit howev ed differ isosurfac reveal complex mechan charg redistribut involv also carbon atom molecul | D056831 | T104 |
36,234,762 | therapeut nutraceut effect polyphenol natur sourc preval cardiovascular diseas oxid stress relat complic chronic age relat ill gradual increas worldwid sever caus includ ineffect medicin treatment therapi toxic inabl provid radic solut diseas necess multipl drug therapi certain chronic diseas therefor necessari altern treatment method sought review polyphenol identifi classifi accord chemic structur sourc polyphenol molecul indic cardioprotect ros scaveng anti age anticanc properti polyphenol compound demonstr result mani studi natur antioxid molecul potenti altern therapeut agent | D000975;D059808 | T121;T109;T123;T044;T039 |
36,234,761 | effect chemic structur interact amin oxidas glucos lipid hydrogen peroxid handl human adipocyt benzylamin natur molecul present food edibl plant capabl activ hexos uptak inhibit lipolysi human fat cell effect depend oxid amin oxidas present adipocyt subsequ hydrogen peroxid product known exhibit insulin like action virtual substrat interact hydrogen peroxid releas enzym potenti modul lipid accumul adipos tissu inhibit enzym also report influenc lipid deposit therefor studi human adipocyt lipolyt lipogen activ pharmacolog entiti design interact amin oxidas high express cell type semicarbazid sensit amin oxidas ssao also known prao vap monoamin oxidas mao result show szv szv behav better substrat benzylamin releas hydrogen peroxid oxid reproduc even exceed insulin like metabol effect fat cell addit sever novel ssao inhibitor szv szv evidenc shown inhibit benzylamin metabol action taken whole find reinforc list molecul influenc regul triacylglycerol assemblybreakdown least vitro human adipocyt novel compound deserv deeper investig mechan interact ssao mao constitut potenti candid therapeut use obes diabet | D006631 | T126;T116 |
36,234,759 | phyto comput intervent diabet mellitus multipl stage use isoeugenol ocimum tenuiflorum combin pharmacokinet molecular model approach present studi anti diabet potenti ocimum tenuiflorum investig use comput techniqu glucosidas amylas aldos reductas glycat multipl stage aim elucid mechan phytocompound tenuiflorum treat diabet mellitus use concept druglik pharmacokinet molecular dock simul molecular dynam simul bind free energi studi isoeugenol phenylpropen propenyl substitut guaiacol found essenti oil plant molecular dock model isoeugenol found inhibit target enzym higher bind effici standard drug furthermor molecular dynam experi reveal isoeugenol stabl bind pocket standard drug use sinc aim discov singl lead molecul higher bind effici stabil isoeugenol select context studi stand contrast comput studi report one compound make difficult offer analys summar recommend isoeugenol potenti wide employ lead inhibitor glucosidas amylas aldos reductas glycat base result silico studi therefor reveal novel phytocompound effect treatment hyperglycemia diabet mellitus | D003920;D009822 | T047;T109 |
36,234,758 | integr system pharmacolog approach elucid multi target mechan solanum surattens hepatocellular carcinoma hepatocellular carcinoma hcc one common malign liver tumor high mortal chronic hepat b c virus aflatoxin alcohol among common caus hepatocellular carcinoma limit report data multipl spectra pathophysiolog mechan hcc make challeng task serious econom burden health care manag solanum surattens surattens herbal plant use mani region asia treat mani disord includ various type cancer previous vitro studi reveal medicin import surattens hepatocellular carcinoma howev exact molecular mechan surattens hcc still remain unclear vitro silico experi perform find molecular mechan surattens hcc studi network pharmacolog approach use multi target mechan surattens explor hcc activ ingredi potenti target surattens found hcc figur furthermor molecular dock techniqu employ valid success activ bioactiv constitu potenti gene hcc present studi investig activ constitu target pathway network determin tumor necrosi factor tnf epiderm growth factor receptor egfr mammalian target rapamycin mtor bcl like protein bcll estrogen receptor er gtpase hras hypoxia induc factor alpha hif harvey rat sarcoma virus also known transform protein p hras akt serinethreonin kinas akt found gene influenc activ ingredi surattens vitro analysi also perform check anti cancer activ surattens human liver cell result show surattens appear act hcc via modul differ molecular function mani biolog process potenti target implic differ pathway furthermor molecular dock employ valid success activ activ compound potenti target result show quercetin success dock inhibit potenti target hcc studi indic activ constitu surattens therapeut target respons pharmacolog activ possibl molecular mechan treat hcc last conclud activ compound surattens act potenti gene along influenc pathway give network analysi system pharmacolog vital role develop util drug current studi lay framework experiment research widen clinic usag surattens | D000348;D006528;D004365;D008113;D032322 | T002;T131;T191;T121;T109;T123 |
36,234,757 | molecular mechanist pathway target natur compound prevent treatment diabet kidney diseas diabet kidney diseas dkd one common complic diabet preval still grow rapid howev effici therapi kidney diseas still limit pathogenesi dkd involv glucotox lipotox inflamm oxid stress renal fibrosi glucotox lipotox caus oxid stress lead inflamm aggrav renal fibrosi review focus vitro vivo experi investig mechanist pathway natur compound exert effect progress dkd accumul collect data reveal natur compound could regul inflamm oxid stress renal fibrosi activ autophagi therebi protect kidney main pathway target review compound includ nrf signal pathway nf b signal pathway tgf signal pathway nlrp inflammasom autophagi glycolipid metabol er stress review present updat overview potenti benefit natur compound prevent treatment dkd progress aim provid new potenti therapeut lead compound refer innov drug develop clinic treatment dkd | D003920;D003928 | T047 |
36,234,756 | biogen synthesi silver nanoparticl use catharanthus roseus cytotox effect vero cell line background type diabet mellitus dm chronic sometim fatal condit affect peopl world nanotherapeut shown tremend potenti combat chronic diseas includ dm enhanc overal impact drug biolog system green synthes silver nanoparticl agnp catharanthus roseus methanol extract c agnp examin primarili cytotox antidiabet effect method character c agnp perform uv vis spectroscopi fourier transform infrar spectroscopi ftir x ray diffract xrd atom forc microscopi afm c agnp trial vero cell line afterward anim model rat result c agnp show standard structur function character reveal ftir xrd analys zetapotenti analysi indic stabil edx analysi confirm format composit cap ag metal cytotox effect ic c agnp vero cell line found gml anim model analys reveal signific differ water intak food intak bodi weight urin volum urin sugar test rat treatment aqueous extract c agnp moreov five group rat includ control diabet group nc pc dg dg dg investig blood glucos glycem control analysi conclus c agnp exhibit posit potenti vero cell line well experiment rat lipid profil diabet group dg signific increas compar control group p lt present studi reveal signific c agnp nanotherapeut | D030008;D003924;D053768 | T047;T073;T002 |
36,234,755 | develop novel pyridin thiazol hybrid molecul potenti anticanc agent novel pyridin thiazol hybrid molecul synthes subject physico chemic character screen cytotox action toward panel cell line deriv differ type tumor carcinoma colon breast lung glioblastoma leukemia normal human keratinocyt comparison high antiprolif activ fluorophenyl methyl pyridin ylamino thiazol yl propenon fluorophenyl methyl pyridin ylamino thiazol yl oxopropylsulfanyl acetylamino benzoic acid ethyl ester reveal ic compound hl cell acut human promyelocyt leukemia pseudo normal human cell line ic compound gt suggest compound might perspect anticanc agent detect select deriv cancer cell line inspir us studi mechan cytotox action shown preincub tumor cell fluzaparib inhibitor parp reduc cytotox activ deriv twice abil compound affect dna nativ caus chang nucleus morpholog allow suggest mechan action novel pyridin thiazol deriv might relat induc genet instabl tumor cell | D000970;D007938;D009369 | T121;T109;T191 |
36,234,754 | synthesi structur activ relationship studi pyrido e purin hh dion deriv target flavin depend thymidyl synthas mycobacterium tuberculosi new class thymidyl synthas ts involv de novo synthesi dtmp name flavin depend thymidyl synthas fdts encod thyx gene discov fdts present prokaryot pathogen human pathogen make attract target develop new antibacteri agent especi multi resist pathogen report herein synthesi structur activ relationship novel seri hitherto unknown pyrido e purin hh dion analogu sever synthet effort done optim regioselect n alkyl organopalladium cross coupl model potenti hit perform generat model interact activ pocket fdts understand guid synthet modif compound evalu hous vitro nadph oxidas assay screen well mycobacterium amp nbsp tuberculosi thyx highest inhibit obtain compound without signific cytotox cc gt pbm cell | D009169 | T007 |
36,234,753 | synthesi novel lipophil polyamin via ugi reaction evalu anticanc activ natur polyamin pas involv process prolifer differenti cancer cell lipophil synthet polyamin lpas induc cell death various cancer cell line current paper demonstr new method synthesi lpas via multicompon ugi reaction subsequ reduct amid group phsih anticanc activ obtain compound evalu mcf hct cancer cell line first time shown anticanc activ lpas piperazin fragment compar aliphat lpas presenc diglycerid fragment structur lpas appear key factor manifest high anticanc activ find studi strong support research field lpas deriv | D000970;D009369 | T121;T109;T191 |
36,234,752 | antiprotozo activ azabicyclo nonan link tetrazol sulfonamid core n aminoalkyl azabicyclo nonan possess antiplasmodi antitrypanosom activ seri termin tetrazol sulfonamido partial structur prepar structur new compound confirm nmr ir spectroscopi mass spectral data singl crystal structur analysi enabl distinct isom antiprotozo activ examin vitro strain plasmodium falciparum trypanosoma brucei rhodesiens stib activ sulfonamid tetrazol deriv show activ submicromolar rang | D000962;D000981 | T121 |
36,234,751 | essenti oil sourc ecofriend insecticid drosophila suzukii diptera drosophilida potenti non target effect spot wing drosophila drosophila suzukii one main invas pest small fruit world thus essenti oil eo select analyz effect toxic repel oviposit suzukii adult addit lethal subleth effect pupal endoparasitoid trichopria anastrepha evalu eo c flexuosus mentha spp highest toxic observ topic applic bioassay suzukii contrast eo c verum c citratus qt citratus c winterianus show highest toxic ingest bioassay suzukii dri residu c verum c citratus qt citratus reduc oviposit suzukii repel bioassay eo analyz repel suzukii femal eo evalu use lc valu product provid mortal less anastrepha adult caus reduct parasit surviv anastrepha femal conclud eo evalu potenti use manag suzukii also serv select activ ingredi formul synthesi new biopesticid | D006927;D007306;D009822 | T109;T131;T204 |
36,234,749 | magnet torus microreactor novel devic sampl treatment via solid phase microextract coupl graphit furnac atom absorpt spectroscopi rout arsenic pre concentr work studi feasibl use novel microreactor base torus geometri carri sampl pretreat analysi graphit furnac atom absorpt miniatur retent total arsenic perform surfac magnet sorbent materi consist mg magnetit fe confin small space insid l polyacryl devic fill intern lumen insid space use geometr design simul theoret studi demonstr notabl improv analyt adsorpt process solid extract surfac compar singl layer geometri torus microreactor geometri brought flow turbul within liquid along curvatur insid devic channel improv effici analyt extract contact therefor lead high preconcentr factor accord design magnet solid phase held intern surfac bed use mm diamet cylindr neodymium magnet allow pass fix volum arsenic aqueous standard solut preconcentr factor found reduc typic characterist mass sensit paramet determin direct measur pg pg show essenti improv arsenic signal sensit absorpt atom spectrometri methodolog emul miniatur micro solid phase extract system flow water pretreat sampl chemic analysi coupl techniqu employ reduc sampl volum graphit furnac atom absorpt spectroscopi | D001151;D006108;D059627 | T059;T131;T121;T109;T196 |
36,234,748 | first phosphoryl triazolyl nucleosid analogu uracil quinazolin dion moieti synthesi antivir evalu seri phosphoryl dialkyl phosphat diaryl phosphat phosphoramid h phosphon phosphat triazolyl nucleosid analogu triazol yl ribofuranos fragment attach via methylen group butylen chain n atom heterocycl moieti uracil quinazolin dion synthes compound evalu antivir activ influenza virus apr hn antivir assay reveal three compound b b show moder activ influenza virus hn ic valu respect first two compound quinazolin dion moieti attach via methylen butylen linker respect triazol yl ribofuranosyl fragment possess diphenyl phosphat substitu compound uracil moieti attach via methylen unit triazol yl ribofuranosyl fragment possess phenyl methoxi l alaninyl phosphat substitu remain compound appear inact influenza virus apr hn result molecular dock simul indirect confirm literatur data inhibit viral replic carri nucleosid analogu triphosph deriv | D053118;D063065 | T109;T131;T005 |
36,234,747 | optim solid phase mesh enhanc sorption headspac spmesh rapid sub ngkg measur isobutyl methoxypyrazin ibmp grape parallel extract headspac volatil multiwel plate use sorbent sheet hs spmesh follow direct analysi real time high resolut mass spectrometri dart hrms use rapid altern solid phase micro extract spme gas chromatographi mass spectrometri gc ms trace level volatil analys howev earlier valid studi spmesh dart ms use isobutyl methoxypyrazin ibmp grape juic show poor correl spmesh dart ms gold standard spme gc ms around compound odor detect threshold lt ngkg grape juic lack suffici sensit detect ibmp concentr grape homogen work report develop valid improv spmesh extract approach lower limit detect lod lt ngkg regul crosstalk well lt calibr rang ngkg optim spmesh dart ms method valid use cabernet sauvignon merlot grape sampl harvest commerci vineyard central valley california n achiev good correl agreement spme gc ms r nativ rang ibmp lt ngkg coupl spmesh lower resolut tripl quadrupol qqq ms via new jumpshot hts dart sourc also achiev low ngkg detect limit throughput improv posit stage optim reduc time spent intra well spmesh area | D027843 | T168;T116;T002;T129 |
36,234,746 | develop uplc msms method studi pharmacokinet interact sorafenib dapagliflozin rat sorafenib sor inhibitor multipl kinas classic target drug advanc hepatocellular carcinoma hcc often coexist type diabet mellitus tdm dapagliflozin dapa sodium glucos cotransport inhibitor sglti wide use patient tdm notabl co administr sor dapa common clinic set uridin diphosph glucuronosyltransferas famili member ugta involv metabol sor dapagliflozin dapa sor inhibitor ugta ugta vitro therefor chang ugta activ caus sor may lead pharmacokinet interact two drug object current studi develop ultra perform liquid chromatographi tandem mass spectrometri uplc msms method simultan determin sor dapa plasma evalu effect co administr sor dapa individu pharmacokinet properti mechan involv rat divid four group sor mgkg alon co administ dapa mgkg seven day dapa mgkg alon co administ sor mgkg seven day liquid liquid extract lle perform plasma sampl prepar chromatograph separ conduct water xselect hss column gradient elut formic acid mm ammonium acet phase acetonitril phase b level ugta messeng rna mrna determin rat liver intestin use quantit real time polymeras chain reaction qrt pcr method success appli studi pharmacokinet interact dapa caus signific decreas maximum plasma concentr cmax area plasma concentr time curv auc sor respect appar volum distribut v zf appar clearanc cl zf signific increas fold respect co administ dapa sor auc elimin half life z dapa signific increas fold respect wherea cl zf signific decreas result qrt pcr show compar control seven day sor pretreat decreas ugta express liver intestin tissu contrast seven day dapa pretreat decreas ugta express liver tissu therefor pharmacokinet interact exist long term use sor dapa ugta may target mediat interact activ surveil treatment outcom advers reaction requir | D006528;D003924;D008113;D000077203 | T191;T047;T109;T121 |
36,234,745 | drug inclus inorgan organ hybrid system control releas osteoporosi drug zoledron bisphosphon bps common pharmaceut treatment use calcium bone relat disord princip one osteoporosi antiresorpt action relat high affin hydroxyapatit main inorgan substitu bone hand phosphon group backbon make excel ligand metal ion combin properti find potenti applic util system control drug releas system crss work third generat bp drug zoledron zol combin alkalin earth metal ion eg sr ba effort synthes new materi metal zol compound oper crss expos appropri experiment condit low ph human stomach thus releas activ drug zol crs network contain sr ba zol physicochem structur character evalu abil releas free zol drug acid driven hydrolysi process various releas kinet paramet determin initi rate releas plateau valu base drug releas result studi attempt correl zol releas effici structur featur crss | D050071;D010024 | T121;T047 |
36,234,744 | select review virtual screen analysi natur product inhibitor nlrp inflammasom nlrp inflammasom current excit target drug discoveri due role various inflammatori diseas howev date nlrp inhibitor reach clinic sever studi use natur product hit compound facilit design novel select nlrp inhibitor review select natur product report literatur nlrp inhibitor particular focus target gout complement survey also report virtual screen zinc natur product databas predict favor chemic featur aid design novel small molecul nlrp inhibitor | D001688;D006073 | T121;T047;T123 |
36,234,743 | discoveri novel pik inhibitor base p crystal structur pik key mediat b cell receptor signal play import role pathogenesi certain hematolog malign chronic lymphocyt leukemia idelalisib target pik specif first approv pik inhibitor cancer therapi recent carri virtual screen cell base assay adapta kinas assay molecular dynam analysi discov novel pik inhibitor identifi nsc lead pik inhibitor nsc excel dock score potent pik inhibitori activ antitumor effect various cancer cell line favor bind mode activ site pik moreov structur modif nsc discov comp form h bond val lys atp bind pocket pik favor conform bind pik addit found n n n trimethyl n methyl h benzo imidazol yl methyl ethan diamin might potenti scaffold structur thus result studi provid far effici approach discov novel inhibitor target pik | D000970;D019869 | T121;T109;T126;T116 |
36,234,742 | evalu nutrit health valu select polish mushroom consid fatti acid profil lipid indic imleria badia boletus eduli cantharellus cibarius popular mushroom econom import poland sinc physic mental develop person mainten good health entail provid bodi adequ nutrient includ plant anim fat aim studi determin fatti acid profil three mushroom speci poland assess nutrit health valu use lipid indic studi mushroom favor fatti acid composit due high percentag polyunsatur fatti acid low valu atherohen index ai thrombogen index ti prove consumpt fungi may decreas risk coronari heart diseas product high hypocholesterolemichypercholesterolem ratio hh health promot index valu assum benefici human health grant possibl use mushroom nutrit peopl hypertens prevent cardiovascular diseas | D000363 | T004 |
36,234,741 | hybrid quinon quinolin deriv synthesi biolog activ molecular dock dt diaphoras nqo hybrid quinon quinolin obtain connect two activ structur oxygen atom strategi allow obtain new compound high biolog activ suitabl bioavail newli synthes compound character various spectroscop method enzymat assay use show compound suitabl dt diaphoras nqo substrat evidenc increas enzymat convers rate relat streptonigrin hybrid test vitro panel human cell line includ melanoma breast lung cancer show also high cytotox activ depend type quinon moieti appli tumor cell line found cytotox activ studi hybrid increas cell line higher nqo protein level breast mcf td lung cancer select hybrid test transcript activ gene encod prolifer marker h histon cell cycl regul p p apoptosi pathway bcl bax molecular dock use examin probabl interact hybrid nqo protein | D000970;D006912;D011804 | T121;T109 |
36,234,739 | oxymatrin allevi gentamicin induc renal injuri rat gentamicin aminoglycosid antibiot common use treat gram negat bacteri infect possess consider nephrotox oxymatrin phytochem abil counter gentamicin toxic investig effect protect mechan oxymatrin rat experiment group follow control oxymatrin group mgkgd gentamicin group mgkgd gentamicin mgkgd plus oxymatrin mgkgd group n rat treat seven continu day result indic oxymatrin allevi gentamicin induc kidney injuri decreas rat kidney indic nag n acetyl beta glucosaminidas bun blood urea nitrogen cre creatin serum level oxymatrin treat group sustain less histolog damag oxymatrin also reliv gentamicin induc oxid nitrat stress indic increas sod superoxidas dismutas gsh glutathion cat catalas activ decreas mda malondialdehyd ino induc nitric oxid synthas nitric oxid level caspas activ also decreas oxymatrin treat group oxymatrin exhibit potent anti inflammatori effect gentamicin induc kidney injuri regul bcl ax nf b mrnas upregul bcl ho nrf mrnas kidney tissu investig reveal renal protect effect oxymatrin gentamicin induc kidney injuri first time effect achiev activ nrfho pathway studi underlin potenti clinic applic oxymatrin renal protect agent gentamicin therapi | D005839;D051267 | T116;T195;T121;T109;T123 |
36,234,738 | electrospun poli hydroxybutyr co hydroxyvaler oliv leaf extract fiber mesh prospect bio base scaffold wound heal polyhydroxyalkano phas famili biopolyest synthes various microorgan due biocompat biodegrad phas propos biomed applic includ tissu engin scaffold oliv leaf extract ole obtain agri food biowast sourc polyphenol remark antioxid properti studi aim incorpor ole insid poli hydroxybutyr co hydroxyvaler phbhv fiber via electrospin obtain bioactiv bio base blend use wound heal phbhvole electrospun fiber size obtain fourier transform infrar chemic analysi show uniform surfac distribut hydrophil oh group confirm presenc ole electrospun fiber main ole phenol releas fiber within day biodegrad scaffold phosphat buffer salin investig demonstr adequ stabil presenc metalloproteinas mmp enzym produc chronic wound scaffold preliminarili test vitro hfff fibroblast hacat keratinocyt suggest adequ cytocompat phbhvole fiber mesh hold promis featur wound heal includ treatment ulcer due long period durabl inflam tissu environ adequ cytocompat | D054813 | T109 |
36,234,737 | herbal arsenal skin ailment review support silico molecular dock studi maintain healthi skin import healthi bodi present skin diseas numer repres major health problem affect age neonat elder worldwid mani peopl may develop diseas affect skin includ cancer herp cellul long term convent treatment creat complic disord vital organ bodi also impos socioeconom burden patient natur treatment cheap claim safe use plant old mankind mani medicin plant part frequent use treat diseas also suitabl raw materi product new synthet agent review plant famili viz fabacea asteracea lamiacea etc use treatment skin diseas provid common compound silico studi summar recent data collect area | D010946;D012871 | T047;T002 |
36,234,736 | applic maldi msms base proteom biomed research matrix assist laser desorptionion maldi mass spectrometri ms one wide use techniqu proteom achiev structur identif character protein peptid includ varieti proteoform due post translat modif ptms protein protein interact ppis maldi ms maldi tandem mass spectrometri msms develop analyt techniqu studi small larg molecul offer picomol femtomol sensit enabl direct analysi biolog sampl biofluid solid tissu tissuecel homogen cell cultur lysat minim procedur sampl prepar last decad structur identif peptid protein achiev maldi msms help research clinician deciph molecular function biolog process cellular compon relat pathway gene product well involv pathogenesi diseas review highlight applic maldi ionize sourc tandem approach ms analyz biomed relev peptid protein furthermor one relev applic maldi msms provid molecular pictur offer situ inform molecular weight protein without label potenti target histolog direct maldi mass spectrometri imag msi use maldi toftof maldi tandem mass spectromet accur sequenc analysi peptid biomark biolog activ compound direct tissu assur complementari essenti spatial data compar obtain lc esi msms techniqu | D035843;D040901 | T091;T062 |
36,234,735 | novel famili cage like culi cuna cuk phenylsilsesquioxan complex hydroxyquinolin ligand synthesi structur catalyt activ first exampl metallasilsesquioxan complex includ ligand hydroxyquinolin famili synthes structur establish singl crystal x ray diffract use synchrotron radiat compound tend form type sandwich like cage cu nuclear li na k complex includ two cisoid pentamer silsesquioxan ligand two hydroxyquinolin ligand latter coordin copper ion correspond alkalin metal ion via deproton oxygen site characterist size alkalin metal ion variat characterist nitrogen ligand hydroxyquinolin vs chloro hydroxyquinolin vs dibromo hydroxyquinolin vs diiodo hydroxyquinolin high influenti format supramolecular structur complex cu na base compound exhibit high catalyt activ toward oxid hydrocarbon h activ hno ii alcohol tert butyl hydroperoxid studi kinet select led us conclud hydroxyl radic play crucial role process | D056831;D015125 | T121;T104;T109;T130 |
36,234,734 | discoveri new vegfr inhibitor design synthesi anti prolif evalu dock md simul studi four new nicotinamid base deriv design antiangiogen vegfr inhibitor congen synthes possess pharmacophor essenti featur bind correct vegfr activ pocket member evalu cytotox vegfr inhibitori potenti compound potent showing valu hct hepg cell respect ic nm regard vegfr enzym inhibit compound arrest growth hct cell pre g g phase induc earli late apoptosi addit compound caus signific decreas tnf il respect consid compound similar dock perform sorafenib vegfr pdb id oh correct bind compound vegfr valid use md simul mm gpsa calcul | D000970;D040301 | T121;T109;T116;T192 |
36,234,733 | bioavail celecoxib formul mesopor magnesium carbon vivo evalu attract approach increas aqueous appar solubl poor solubl drug formul amorph state present studi celecoxib poor solubl drug success load mesopor magnesium carbon mmc amorph state via solvent evapor method crystal celecoxib suppress reaction carrier detect mmc formul evalu vitro vivo term oral bioavail celebra commerci avail formul use refer two celecoxib formul oral administr male rat averag n anim per group blood sampl plasma taken anim differ time point administr statist differ p gt auc inf two formul result show mmc may promis drug deliveri excipi increas bioavail compound solubl limit absorpt | D005079 | T120;T122 |
36,234,732 | comparison protein bioaccess soymilk gel induc glucono lacton lactic acid bacteria studi protein bioaccess soymilk gel produc addit glu cono lacton gdl ferment lactic acid bacteria lab examin use vitro gastrointestin simul digest model vitro protein digest solubl protein content free amino acid content degre hydrolysi electrophoret pattern peptid content measur result suggest acid induc soymilk gel generat gdl sg show consider reduc vitro protein digest compar soymilk gel induc lab sl p lt gastric digest stage dramat higher p lt solubl protein content observ sg mgml sl mgml howev later intestin digest phase result opposit end gastrointestin digest phase content small peptid signific differ p gt sl mgml sg mgml sl show higher content free amino acid gl sg gl general soymilk gel induc lab higher protein bioaccess soymilk gel coagul gdl | D056546;D041942 | T007;T168 |
36,234,731 | effect nanoparticl dox mir b dna damag repair glioma u cell under mechan glioma common primari craniocerebr malign tumor aris cancer glial cell brain spinal cord qualiti life prognosi patient diseas still poor doxorubicin dox one tradit econom chemotherapeut drug treatment glioma toxic effect normal cell resist tumor cell dox make applic dox treatment glioma gradual less effect solv problem co encapsul dox endogen tumor suppressor mir b nanoparticl nps nanoprecipit method passiv target glioma cell vitro experi show mir b dox effect encapsul nanoparticl differ ratio target yes proto oncogen yes affect adenosin monophosph amp activ protein kinas ampk p pathway induc brain glioma cell apoptosi also affect dna damag repair process inhibit cell prolifer obtain data suggest co deliveri dox mir b could achiev synergist effect tumor suppress nanosystem base co deliveri tumor suppress mirna chemotherapeut agent may promis combin therapeut strategi enhanc anti tumor therapi | D005910;D035683;D053758 | T191;T123;T073;T114 |
36,234,730 | synthesi molecular dock preclin evalu new succinimid deriv cardioprotect hepatoprotect lipid lower effect cardiac hepatotox major concern develop new drug better altern treatment sought protect vital organ toxic pharmaceut regard preclin studi design investig histopatholog effect new succinimid deriv comp myocardi liver tissu biochem effect select cardiac biomark hepat enzym lipid profil initi lethaltox dose determin follow group select albino rat five group group n control group receiv daili oral salin day fu fluorouracil group receiv oral salin daili day ad administr singl dose fu mgkg ip day studi atenolol group receiv oral atenolol mgkg day fu mgkg ip day protocol similar two group rat treat test compound comp administ mgkg ip mgkg ip day follow fu mgkg ip day toxic induc fu manifest increas serum creatinin kinas myocardi band ck mb troponin ctni lactat dehydrogenas ldh lipid profil select liver enzym includ alp alkalin phosphatas alt alanin transaminas ast aspart aminotransferas bt bilirubin total bd direct bilirubin biomark high signific decreas administr mention dose test compound mgkg mgkg similar histolog examin reveal cardiac hepat tissu toxic fu howev toxic effect also signific recoveredimprov administr comp said dose deriv show dose depend effect effect dose mgkg bodi weight bind energi data comput via dock simul reveal compound interact toward human beta adrenerg g protein coupl receptor kcalmol slight stronger affin calcium channel type kcalmol conclus histolog biochem result show test compound comp promin cardioprotect hepatoprotect lipolyt effect fu induc toxic subject anim model | D000469;D019210 | T126;T116;T123 |
36,234,729 | multicompon molecular system base porphyrin triazin carboran synthesi character trichloro triazin cyanur chlorid excel coupl reagent prepar high structur multifunct molecul three compon system base porphyrin cyanur chlorid carboran cluster prepar one pot stepwis amin cyanur chlorid aminophenyl triphenylporphyrin follow replac remain chlorin atom carboran n nucleophil variant triazin deriv contain porphyrin carboran residu biolog activ compound maleimid glycin methyl ester well thioglycol acid mercaptoethanol hexafluoroisopropanol also prepar care control reaction temperatur substitut reaction allow synthesi desir compound good high yield structur synthes compound determin uv vis ir h nmr b nmr maldi tof lc ms spectroscop data dark photocytotox well intracellular local photoinduc cell death compound evalu | D001880;D011166 | T104;T123;T109 |
36,234,728 | fast detect cadmium chocol solid sampl electrotherm vapor atom absorpt spectrometri applic dietari exposur risk assess work rapid detect method use solid sampl electrotherm vapor atom absorpt spectrometri ss etv aa establish cadmium chocol instrument system includ solid sampl etv unit catalyt pyrolysi furnac aa detector gas suppli system air pump hydrogen generat herein mgo materi mm particl size first employ replac kaolin filler previous use shorten peak width therebi improv sensit mlmin air chocol sampl heat c remov water organ matric suppli mlmin hydrogen turn air mlmin n h mixtur gas form acceler cd vapor chocol residu c optim condit detect limit lod obvious lower pgg vs previous pgg r gt relat standard deviat rsd repeat measur real chocol sampl rang indic favor precis cd recoveri rang prove satisfi accuraci thus total analysi time less min without sampl digest process thereaft chocol sampl differ brand produc countri china market collect measur propos method base measur cd concentr dietari exposur assess perform chines resid target hazard quotient thq valu less prove signific health risk intak chocol cadmium chines resid | D002104;D000069956 | T131;T196;T168 |
36,234,727 | biowast deriv carbon dot perspect biomed potenti today sustain natur resourc includ biowast consid attract start materi fabric biocompat biodegrad carbon dot cds due benefit avail low cost biorenew environment benign attribut carbonac nanomateri wide explor field sensingimag optoelectron photocatalysi druggen deliveri tissu engin regen medicin cancer theranost design multifunct biowast deriv cds high efficaci toxic ratio sustain target drug deliveri along imag potenti open new window opportun toward theranost applic howev crucial challeng regard absorptionemiss wavelength convers emissionmultiphoton fluoresc mechan phosphoresc cds still need address attain maximum function efficaci futur studi ought focus optim synthesi techniquescondit evalu influenc nucleationgrowth process structuresproperti control morphologys find photoluminesc mechan reproduc synthesi techniqu anoth critic import factor need address futur herein recent develop relat biowast deriv cds respect biomed applic deliber focus import challeng futur perspect | D002244;D045663 | T121;T196;T073 |
36,234,726 | electrochem spectroscop character oxid intermedi form vitamin e vitamin e collect lipophil phenol compound base chroman ol rich fascin oxid chemistri involv rang intermedi form propos import biolog function review avail electrochem spectroscop data oxid intermedi summar along discuss lifetim chemic stabil either typic similar phenol chroman ol deriv compound atyp uniqu specif oxid isomer form vitamin e overal electrochem oxid mechan vitamin e summar involv loss two electron one proton although electron transfer chemic step control progress along differ pathway prolong lifetim discreet intermedi modifi experiment condit appli electrochem potenti aqueous non aqueous solvent ph depend environ electrochem reaction involv singl electron transfer set proton coupl electron transfer pcet well homogen disproportion comproportion step intermedi speci produc via chemic electrochem oxid includ phenol phenol cation radic phenoxyl neutral radic dicat diamagnet cation phenoxenium para quinon methid cation radic tocopherol atyp long live compar cation radic phenol due relat weak acid diamagnet cation deriv tocopherol except long live compar diamagnet cation isom vitamin e compar phenoxenium cation deriv phenol compound contrast lifetim phenoxyl radic deriv tocopherol consid critic biolog reaction typic expect compound structur featur longer time via hydrolysi reaction hydroxi para quinon hemiket quinon form oxid intermedi undergo reduct process form intermedi anion radic dianion method generat oxid intermedi chemic photochem electrochem method discuss along summari final product vari depend method use oxid sinc intermedi main surviv solut often monitor use uv vis spectroscopi ftir raman spectroscopi epr spectroscopi spectroscop techniqu sometim combin fast photoiniti excit time resolv spectroscopi detect short live speci | D019800;D014810 | T121;T109;T127 |
36,234,725 | advocaci medicin plant artabotri hexapetalus yingzhao antimalari yingzhaosu endoperoxid medicin plant artabotri hexapetalus synonym uncinatus odoratissimus known yingzhao chines extract plant long use asian folk medicin treat various symptom diseas includ fever microbi infect ulcer hepat disord health problem particular extract root fruit plant use treat malaria numer bioactiv natur product isol plant main aporphin artabonatin artacinatin benzylisoquinolin hexapetalin alkaloid terpenoid artaboterpenoid flavonoid artabotrysid butanolid uncinin artapetalin small seri endoperoxid known yingzhaosu natur product confer antioxid anti inflammatori antiprolif properti plant extract lead compound yingzhaosu display mark activ malaria parasit plasmodium falciparum p berghei total synthes develop access yingzhaosu compound analogu potent compound c epi yingzhaosu simpler molecul dioxan unit mechan action yingzhaosu point iron ii induc degrad lead format two alkyl speci unsatur keton cyclohexyl radic react vital parasit protein bioreduct activ yingzhaosu endoperoxid also occur heme iron complex mechan action yingzhaosu endoperoxid discuss promot chemic pharmacolog studi neglect high interest bioactiv compound yingzhaosu ac repres use templat design novel antimalari drug | D029061;D000962;D001060;D044182;D005493;D008288;D010946;D012717 | T121;T047;T109;T002 |
36,234,724 | antioxid effect picein neuroprotect potenti review literatur neurodegen diseas ndds main caus dementia elder cure date current avail therapi focus symptom remiss ndds progress despit treatment eventu result death patient sever year burden patient caregiv therefor necessari investig agent tackl diseas pathogenesi effici slow halt diseas progress hope cure patient prevent burden mortal accord recent research focus diseas modifi treatment neuroregen neuroprotect effect purpos necessari understand pathogenesi ndds shown oxid stress play import role damag central nervous system progress neurodegen disord furthermor mitochondri dysfunct accumul unfold protein includ beta amyloid tau protein synuclein suggest accord cellular molecular studi investig efficaci sever natur compound herb nutrit agent neuroprotect antioxid properti popular herb suggest treatment andor prevent ndds includ withania somnifera ashwagandha ginseng curcumin resveratrol baccopa monnieri ginkgo amp nbsp biloba herb ginseng preclin clinic evid avail support effect howev other cellular anim studi avail line scant literatur term effect herbal compound ndds also herbal agent disregard picein one herbal agent investig studi picein activ ingredi sever herb thus extract differ type herb make avail shown anti inflammatori properti cellular plant studi howev date one studi suggest neuroprotect properti furthermor cellular studi shown anti inflammatori effect picein therefor review avail literatur requir summar result studi picein date review studi seem address issu thus present studi gather avail inform antioxid potenti neuroprotect properti picein possibl effect treat ndds also summar plant picein extract order guid research futur investig | D003474;D019636;D018696;D005894;D032341 | T047;T002;T121;T109;T130;T169 |
36,234,723 | analysi protein protein interact intermolecular bond predict protein protein interact often involv complex system intermolecular interact residu atom bind site comprehens explor interact help reveal key residu involv protein protein recognit obvious use protein analysi techniqu paper present extend diffbond novel method identifi classifi intermolecular bond appli standard definit bond chemic literatur explain protein interact diffbond predict intermolecular bond four protein complex barnas barstar rapa raf smad smad subset complex form three finger toxin nachr base valid manual literatur search comparison two protein complex skempi dataset diffbond abl identifi intermolecular ionic bond hydrogen bond high precis recal identifi salt bridg high precis diffbond predict bond exist also strong correl observ gibb free energi chang electrostat complementar mutat experi diffbond power tool predict character influenti residu protein protein interact predict support research mutat experi drug design | D006860 | T070 |
36,234,722 | ascorb primari antioxid mammal ascorb vitamin c primat function cofactor number enzymat reaction repres prolyl hydroxylas antioxid due abil donat electron most accomplish non enzymat reaction mammal ascorb direct react radic speci convert ascorbyl radic follow dehydroascorb ambigu physiolog relev ascorb observ vivo situat could attribut part presenc redox system pro oxid properti ascorb mammal abl synthes ascorb glucos also consid obstacl verifi action addit anim natur defici ascorb synthesi guinea pig od rat three strain mice genet remov respons gene gulo rgn akra ascorb synthesi establish use investig physiolog role ascorb studi use mice along ascorb transport svct defici mice larg support abil protect oxid insult combin action ascorb regul epigenet antioxid appear effect prevent cancer develop pharmacolog dose ascorb dehydroascorb may exert tumoricid activ redox depend mechan | D000975;D001205 | T121;T109;T127;T123;T044;T039 |
36,234,721 | comparison antihypertens activ phenol acid phenol acid found cereal legum veget fruit various biolog function aim compar antihypertens potenti differ phenol acid evalu ace inhibitori activ cytoprotect capac eahi endotheli cell addit explor mechan under antihypertens activ sinap acid phenol acid studi sinap acid caffeic acid coumar acid ferul acid signific inhibit ace activ moreov gallic acid sinap acid ferul acid signific enhanc intracellular product base result gsh deplet ros product mda level analys sinap acid select studi mechan under antihypertens effect sinap acid decreas endotheli dysfunct enhanc express antioxid relat protein sinap acid increas phosphoryl eno akt dose depend manner find indic potenti sinap acid treatment hypertens | D000959;D003373 | T121;T109;T123 |
36,234,720 | content determin releas characterist six compon differ phase glycyrrhiza glabra nux vomica decoct uplc msms decoct turn complex multiphas system follow exposur high temperatur complex chemic environ howev differ concentr key activ ingredi differ phase state releas drug sedimentari phase yet elucid simpl ultra perform liquid chromatographi tandem mass spectrometri uplc msms method develop valid simultan quantit determin brucin strychnin liquiritin isoliquiritin isoliquiritigenin glycyrrhiz acid concentr appli compar content differ phase measur releas characterist sedimentari phase glycyrrhiza glabra nux vomica decoct ngd result show method select precis intraday interday matrix effect recoveri stabil result accept accord guidelin method sensit reliabl content determin result show toxic strychnin sedimentari phase account total compon differ compon exhibit differenti releas differ media compon releas artifici intestin fluid h sever compon conform primari kinet model ritger peppa model toxic compound exhibit slow releas thus conform ritger peppa model studi provid standard refer studi investig reduct toxic combin glycyrrhiza glabra glycyrrhiza glabra l nux vomica strychno nux vomica l | D031461 | T002 |
36,234,719 | compar metabolom analysi moromi ferment use differ aspergillus oryza strain aspergillus oryza oryza import starter ferment koji moromi howev effect differ oryza strain qualiti moromi rare studi reason studi analyz physicochem properti enzym activ sensori qualiti metabolit profil moromi sampl ferment use two strain oryza kccmp moromi kccmp moromi newli isol ferment soy food compar commerci oryza strain control amino type nitrogen content moromi moromi sampl higher control moromi amylas proteas activ also higher moreov metabolit profil moromi signific alter accord strain particular level mani amino acid peptid nucleotid acid compound alter result chang sensori qualiti moromi although volatil compound investig result suggest qualiti moromi signific differ newli isol strain especi oryza kccmp superior commerci strain term tast relat substanc therefor strain could use good starter produc moromi soy sauc good sensori qualiti | D001236;D045730 | T168;T004 |
36,234,718 | target hydroxybenzo acid mitochondria strategi delay skin age vitro approach target antioxid mitochondria consid promis strategi prevent cellular senesc skin age studi investig whether four hydroxybenzo acid base mitochondria target antioxid mitoben mb could use potenti activ ingredi prevent senesc skin cell first evalu chemic stabil cytotox genotox mitochondri toxic compound follow test antioxid protect capac two less toxic compound human skin fibroblast assess effect best hit senesc inflamm mitochondri remodel skin cell model also test mutagen potenti cytotox mitochondri toxic rank produc mb lt mb mb lt mb mb lt mb lt mb lt mb respect result suggest pyrogallol base compound mb mb lower cytotox pyrogallol deriv mb contain carbon spacer show potent antioxid protect activ hydrogen peroxid cytotox skin cell model mb also decreas transcript relat senesc sum mb biolog safeti profil good chemic stabil lack mutagen combin anti senesc effect convert mb good candid develop activ ingredi skin anti age product | D000975;D015595 | T121;T042;T123;T044;T039;T033 |
36,234,717 | phosphatidylcholin cation tyrosin complex motif membran bind bacteri phospholipas c phosphatidylinositol specif phospholipas c pi plc enzym virul factor mani gram posit organ specif activ bacillus thuringiensi pi plc signific increas ad phosphatidylcholin pc vesicl compos substrat phosphatidylinositol part inclus pc reduc appar k vesicl bind much fold compar pc rich vesicl pi vesicl review summar experiment work local site bt pi plc pc bound pc cholin cation tyr complex ii comput work includ atom molecular dynam simul refin origin complex found second persist pc cation tyr complex complex critic vesicl bind result led model pc function alloster effector enzym alter protein dynam stabil open activ site conform | D010738;D014443 | T121;T126;T116;T123 |
36,234,716 | polyphenol character antioxid antihyaluronidas antimicrobi activ young leav stem extract rubus caesius l fruit main food part european dewberri rubus caesius l known sourc polyphenol antioxid littl attent paid leav stem especi young first year stem purpos work analyz first time water ethanol extract obtain young fresh develop leav stem european dewberri determin antioxid biolog activ wherea paper describ biolog properti leav collect summer autumn phytochem profil chang grow season quantit qualit content flavonoid glycosid flavonoid aglycon analyz use revers phase liquid chromatographyelectrospray ionize tripl quadrupol mass spectrometri lc esi msms multipl reaction monitor mrm abil inhibit hyaluronidas well antioxid activ diphenyl picrylhydrazyl dpph ferric antioxid power frap estim extract also analyz gram posit gram negat bacteria result qualit phytochem analysi indic presenc flavonoid aglycon flavonoid glycosid highest amount tilirosid hyperosid isoquercetin astragalin rutin catechin ethanol extract dpph frap test prove high antioxid activ extract leav stem antihyaluronidas assay reveal first time water ethanol extract obtain stem exhibit abil inhibit hyaluronidas activ result ic gml respect antimicrobi activ never analyz european dewberri highest clostridium bifermentan clostridium sporogen anaerob sporul rod well enterococcus faecali water ethanol extract | D002392;D065856 | T002;T121;T109;T168;T129 |
36,234,715 | identif photocatalyt alkaloid coptidi rhizom offlin hplcccscd approach natur product continu valuabl sourc activ metabolit howev research natur product most focus biolog effect chemic util less explor furthermor low throughput bottleneck classic natur product research work new offlin hplcccscd high perform liquid chromatographi follow co crystal singl crystal diffract workflow develop great expedit discoveri activ compound crude natur product extract photoact total alkaloid herbal medicin coptidi rhizom first separ hplc individu peak collect suitabl coform screen ad individu peak solut observ precipit redissolv use co crystal seven new co crystal obtain singl crystal subject x ray diffract analysi molecular structur seven alkaloid milligram crude extract resolv within three day nds great decreas requir crystal amount alkaloid nanoscal enabl rapid stoichiometr inclus major alkaloid full occup typic without disord afford well refin structur noteworthi anomal scatter coform sulfur atom enabl reliabl assign absolut configur stereogen center moreov identifi alkaloid first found photocatalyst green synthesi benzimidazol studi demonstr new green phytochem workflow great acceler natur product discoveri complex sampl | D000470;D001600;D001688;D004365 | T121;T131;T109;T123 |
36,234,714 | comparison differ volatil extract method identif fishi odor fish product studi conduct analyz volatil odor compound key odor activ compound fish soup use fish scarp bone five extract method includ solid phase microextract spme dynam headspac sampl dhs solvent assist flavor evapor safe stir bar sorptiv extract sbse liquid liquid extract lle compar spme final select best extract method studi volatil odor compound analyz gas chromatographi olfactometri mass spectrometri gc ms comprehens two dimension gas chromatographi olfactometri mass spectrometri gc gc ms techniqu key odor activ compound identifi via aroma extract dilut analysi aeda relat odor activ valu r oav calcul total volatil compound identifi gc ms among declar odor activ compound wherea volatil compound identifi gc gc ms among declar odor activ compound studi result reveal octen one pentylfuran e octen octen one hexan octen ol methylhept en one e z nondien ethyl dimethylpyrazin key odor activ compound fish soup | D009812;D055549 | T109;T120;T070 |
36,234,713 | direct vitro comparison anti leishmani activ differ oliv oil total polyphenol fraction assess combin effect miltefosin bioactiv compound present edibl product oliv tree extens studi favor effect various diseas risk factor demonstr aim studi perform compar analysi anti leishmani effect total phenol fraction tpfs deriv extra virgin oliv oil differ phenol content divers quantit pattern moreov present studi investig associ miltefosin standard anti leishmani drug extracellular promastigot intracellular amastigot viscerotrop dermotrop leishmania strain chemic composit tpfs determin high perform liquid chromatographi diod array detect hplc dad analysi parasit growth kinet reactiv oxygen speci product apoptot event determin microscopi flow cytometri result reveal presenc oleacein olea oleocanth oleo secoiridoid enhanc anti leishmani effect tpf associ tpfs miltefosin suggest addit leishmania infantum leishmania major promastigot antagonist intracellular amastigot evalu modifi isobologram method obtain data verifi tpfs bioactiv dietari extract strong anti leishmani activ highlight fraction richer olea oleo phenol compound possess stronger inhibitori effect parasit studi may contribut improv therapeut approach leishmaniasi | D000981;D018320 | T121;T204 |
36,234,712 | myricetin discoveri novel natur human enpp inhibitor virtual screen molecular dock molecular dynam simul mmgbsa studi recent reveal natur occur myricetin inhibit ectonucleotidas ectonucleotid pyrophosphatasephosphodiesteras enpp turn treat ischem cardiac injuri howev due myricetin poor druggabl develop relat limit necessit discoveri novel enpp inhibit myricetin analog altern studi bind model myricetin enpp elucid molecular dock molecular dynam studi subsequ virtual screen self develop flavonoid natur product databas fnpd led identif two flavonoid glycosid cas potenti enpp inhibitor dock score mmgbsa bind energi predict might higher inhibitori effect myricetin studi provid strong foundat futur develop ischem cardiac injuri drug | D001688;D056004 | T121;T066;T044;T123 |
36,234,711 | silver catalyz site select c sp h bond amin secondari primari c sp h bond sulfam widespread numer pharmacolog activ molecul paper silverbathophenanthrolin catalyz intramolecular select amin primari c sp h bond secondari c sp h bond sulfam ester produc cyclic sulfam good yield high site select dft calcul reveal interact sulfam l make molecul firm attach catalyst benefit catalysi reaction vitro anticanc activ final product evalu mcf breast cancer cell | D004952;D012834 | T109;T196 |
36,234,710 | bio guid screen antioxid anti inflammatori hypolipidem potenti support non target metabolom analysi crepi spp studi design evalu chemic fingerprint antioxid anti inflammatori hypolipidem activ select crepi speci collect greec name c commutata c dioscoridi c foetida c heldreichiana c incana c rubra phitosia crocifolia former known crepi crocifolia phytochem analys sampl measur carri use nuclear magnet reson nmr spectroscopi liquid chromatographi coupl mass spectrometri lc ms extract evalu vitro radic scaveng activ dpph assay total phenol content folin ciocalteu vivo paw edema reduct hypolipidem activ experiment mous protocol among test extract c incana present highest gallic acid equival gae mgml highest antioxid activ ic mgml vitro well highest anti inflammatori activ edema reduct vivo moreov hypolipidem protocol extract increas plasma total antioxid capac tac decreas cholesterol well triglycerid accord fraction extract phytochem result biolog effect may associ rich phenol composit caffeoyl tartar acid deriv cichor caftar acid regard promin bioactiv special metabolit present studi contribut knowledg regard phytochem pharmacolog profil crepi spp | D000975;D027468 | T002;T121;T123;T044;T039 |
36,234,709 | improv isotop label method quantifi deamid cobratid use high resolut quadrupol orbitrap mass spectrometri protein deamid sever alter physicochem characterist biolog function protein therapeut cobratid non addict analges wide clinic accept howev asn residu posit n terminus cobratid amino acid sequenc n tend degrad purif storag transport characterist could sever affect drug safeti clinic efficaci cobratid tradit method quantit deamid report previous research characteris low effici accuraci qualiti control cobratid via method limit herein develop improv label method base detect uniqu peptid ie protein fragment cobratid contain n deamid hotspot enzymolysi use orbitrap high resolut mass spectromet quantifi deamid cobratid limit detect quantif method reach respect inter intra day precis valu method lt accuraci label strategi valid use sampl contain synthesis peptid known ratio deamid impur also compar final total deamid result previous develop capillari electrophoresi method recoveri deamid asp deamid isomeris iso asp total deamid respect robust method confirm verifi chromatograph paramet result demonstr applic label strategi detect protein deamid lay robust foundat protein therapeut studi drug qualiti consist evalu | D000577;D010455 | T121;T109;T116 |
36,234,708 | physicochem properti vitro digest starch trace rutinosidas varieti tartari buckwheat manten kirari recent develop novel tartari buckwheat varieti manten kirari trace rutinosidas activ use manten kirari enabl us make rutin rich food product low bitter studi intend evalu physicochem properti vitro digest starch isol manten kirari comparison repres common buckwheat varieti kitawasesoba tartari buckwheat varieti hokkai japan also use lowest content amylos found manten kirari starch highest kitawasesoba starch manten kirari starch exhibit larger median granul size higher valu peak viscos rvu breakdown rvu other valu onset temperatur gelatin c kitawasesoba c manten kirari c hokkai manten kirari hokkai starch digest slowli kitawasesoba starch result provid fundament inform concern expand use manten kirari function food | D019612;D064028 | T168;T002 |
36,234,707 | hplc ms analysi chlorophyl green tea establish differ among varieti green tea nonfer tea qualiti measur green color howev categori encompass high number tea varieti differ cultiv process exampl leaf stembubbl tea plant cultiv light shadow regim powder unpowd tea etc variabl determin differ qualiti among green tea matcha sencha gyokuro etc consequ differ valu market purpos determin variabl exert influenc chlorophyl profil establish characterist profil specif green tea aim analyz chlorophyl profil differ green tea varieti via hplc hr esiapci ms identifi differ chlorophyl compound first time hydroxi chlorophyl hydroxi pheophytin hydroxi lacton pheophytin identifi green tea shadow tea matcha sencha light regimen green tea statist differenti total chlorophyl content b ratio howev matcha tea contain higher proport chlorophyl b among green tea varieti analyz justifi higher qualiti price varieti chlorophyl metabolit pheophytin pyropheophytin oxid chlorophyl indic various process storag condit | D010674;D013662 | T109;T123;T168 |
36,234,704 | iodin mediat alkoxyselenyl alken dien element selenium one pot synthesi linear cyclic alkoxyselenid develop iodin mediat three compon reaction element selenium alken dien alcohol selenyl hexadien give di methoxymethyl tetrahydroselenophen methoxi methoxymethyl tetrahydro h selenopyran via exo trig endo trig cyclize octadien afford linear adduct two termin doubl bond cyclooctadien result one diastereom dialkoxi selenabicyclo nonan via exo trig cyclize diethenyl tetramethyldisiloxan first ring substitut repres rare class heterocycl oxaselenadisilinan obtain high yield | D007455;D012643 | T121;T123;T196 |
36,234,703 | effect germin avenanthramid content oat vitro antisensit activ studi method base ultraperform liquid chromatographi coupl high field quadrupol orbitrap high resolut mass spectrometri uhplc qe hf hrms platform establish trace determin three major avenanthramid avn ms condit determin avn optim crack method avenanthramid analyz linear rang result correl coeffici gl gt respect establish method employ determin avn content oat differ germin time result indic avn content zaohua bayou oat increas time respect germin total avn content oat varieti reach maximum fifth day germin gg zaohua bayou oat respect furthermor studi investig antiallerg antioxid activ germin oat via hyaluronidas inhibit diphenyl picrylhydrazyl dpph scaveng assay antiallerg dpph scaveng abil ungermin form oat varieti weaker howev fifth day germin inhibit rate anthranilamid hyaluronidas reach zaohua bayou oat varieti respect antiallerg abil oat increas signific fifth day germin term antiallerg capac dpph clearanc zaohua bayou oat respect two indic exhibit similar trend find demonstr avn exhibit good antisensit antioxid properti antisensit effect correl posit avn content | D018926;D018554 | T121;T002 |
36,234,702 | ellag acid increas stress resist via insulinigf signal pathway caenorhabd elegan ellag acid natur polyphenol found various fruit veget numer studi shown ellag acid benefici effect human health studi investig stress resist action ellag acid caenorhabd elegan c elegan notabl ellag acid prolong lifespan c elegan ultraviolet radiat stress heat stress oxid stress pseudomona aeruginosa infect stress respect furthermor mechan ellag acid reduc damag caus ultraviolet radiat c elegan explor ellag acid could signific induc nucleus transloc daf therebi activ seri target gene resist ultraviolet radiat stress moreov ellag acid also signific increas express sod time activ superoxid dismutas time clean harm reactiv oxygen speci c elegan expos ultraviolet radiat stress daf mutant daf daf doubl mutant worm expos ultraviolet radiat ellag acid could longer prolong lifespan result indic ellag acid play import role resist ultraviolet radiat stress c elegan probabl insulinigf signal pathway depend way | D017173;D029742 | T116;T204 |
36,234,701 | character differenti fresh orang juic varieti base convent physicochem paramet flavonoid volatil compound use chemometr present studi focus possibl differenti fresh unprocess orang juic accord botan origin varieti base use convent physico chemic paramet flavonoid volatil compound combin chemometr purpos orang seven differ varieti collect harvest year central southern greec physico chemic paramet determin includ electr conduct acid ph total solubl solid flavonoid hesperidin neohespseridin quercetin naringin naringenin determin use high perform liquid chromatographi hplc dad final volatil compound determin use headspac solid phase micro extract combin gas chromatographi mass spectrometri hs spmegc ms statist treatment data multivari techniqu show orang juic varieti signific p lt impact analyt paramet classif rate differenti orang juic accord orang varieti use multivari analysi varianc manova linear discrimin analysi lda base cross valid method | D032084;D006569;D055549 | T002;T121;T109;T127;T168 |
36,234,700 | safeti assess food drink consum peopl gluten free diet natur gluten free food process food contain inform potenti presenc gluten pose hypothet threat peopl food allergi celiac diseas patient follow strict gluten free diet alway therefor aim research analyz certifi gluten free natur gluten free product without label may contain gluten inform term content gluten protein enzym immunoassay agraqu gluten g elisa test kit use analysi product use research found contain gluten ppm one product label gluten free contamin gluten ppm cider cake addit research also examin gluten content commerci beer contain barley malt label gluten free research shown sampl safe strict gluten free diet research clear show mani manufactur although monitor product presenc gluten offer safe product although recommend gluten free diet therefor strong need increas frequenc test food manufactur presenc gluten product number product approv peopl gluten free diet continu increas | D002446;D019648 | T047;T168 |
36,234,699 | ad mealworm tenebrio molitor l powder wheat bread effect physicochem sensori microbiolog qualiti end product entomophagi consumpt insect gain popular research carri far use edibl insect food industri shown valuabl sourc protein signific affect function sensori properti food edibl insect also contribut sustain environ friend food product take account influenc ad insect powder physicochem properti sensori characterist microbiolog qualiti wheat bread evalu studi aim partial replac wheat flour bread mealworm powder molitor produc protein fortifi bread bread contain mealworm powder show similar densiti water activ compar control wheat bread addit mealworm powder negat affect properti bread total color differ increas signific p lt insect flour share bread formul rang protein content bread fortifi mealworm powder increas compar control bread wherea fat content increas result sensori evalu reveal modif recip depend mealworm powder addit level signific p lt affect bread color odor flavor overal sensori qualiti research show optim enrich level use mealworm flour bread recip moreov obtain variant bread character good microbiolog qualiti bake bread yeast mold found period day storag number yeast mold bread variant relat low conclud result confirm use insect powder make protein fortifi bread good qualiti compar tradit wheat bread | D001939;D013712 | T168;T204 |
36,234,698 | andrographi paniculata dosag form advanc nanoparticul deliveri system overview andrographi paniculata well known asian medicin plant major phytoconstitu diterpen lacton andrographolid deoxyandrographolid neoandrographolid world health organ monograph select medicin plant show paniculata extract major diterpen lacton promis anti inflammatori antidiabet antimalari anticanc antifung antibacteri antioxid hypoglycem activ howev activ phytochem poor water solubl bioavail deliv convent dosag form biolog barrier mitig extract isol compound deliv nanoparticl review discuss exist studi market product paniculata solid liquid semi solid gaseous dosag form either extract isol pure compound well deficit reach maximum bioavail pharmaceut pharmacolog activ paniculata nano deliveri system also discuss | D035685;D000962;D004224;D010946 | T121;T109;T002 |
36,234,697 | nanolipogel load tea tree oil manag burn gc ms analysi vitro vivo evalu gc ms analysi tea tree oil tto reveal volatil compon sesquiterpen hydrocarbon alcohol major detect class tto efficaci mask hydrophob nanoencapsul address drawback result show tto load solid lipid nanoparticl sln compos glyceryl monostear ww poloxam ww spheric shape core shell microstructur tto sln show high entrap effici small particl size nm low polydispers index high negat zeta potenti mv moreov exhibit faster activ agent releas almost complet within h compar formul tto slns well plain oil tto sln incorpor cellulos nanofib gel isol sugarcan bagass form tto load nanolipogel shear thin behavior second degre thermal injuri induc wistar rat burn skin area treat daili day tto load nanolipogel compar unmed nanolipogel tto load convent gel normal salin control measur burn contract prove tto load nanolipogel exhibit signific acceler skin heal confirm histopatholog examin well quantit assess inflammatori infiltr studi highlight success propos nanotechnolog approach improv efficaci tto use repair skin damag induc burn | D002056;D031786;D020947 | T121;T002;T109;T037 |
36,234,696 | evalu differ extract method phenol profil antioxid potenti ceratonia siliqua l pod extract present work design investig effect differ extract process name ultrason assist supercrit fluid microwav assist soxhlet appli carob pod total phenol quantif antioxid activ assess mean rapid vitro spectrophotometr assay phenol profil identifi use ultra high perform liquid chromatographi coupl mass spectrometri result reveal phenol compound antioxid capac vari signific natur extract process content total phenol compound rang mg gaeg dw content total flavonoid vari mg qeg dw content condens tannin fluctuat mg ce g dw extract perform differ antioxid activ determin dpph assay produc dose depend respons ic extend gml hplc analysi enabl identif nine compound function studi extract method phenol compound content posit correl antioxid activ | D007887;D044945 | T121;T109;T002 |
36,234,695 | analyt approach offici food safeti control lc orbitrap hrms screen method multiresidu determin antibiot cow sheep goat milk presenc unauthor substanc residu veterinari medicin chemic contamin food repres possibl health concern reason complet legisl framework establish european union eu defin maximum limit allow food carri surveil program control presenc substanc offici food control laboratori order ensur high level consum protect must respond challeng improv harmon perform analyt method use analysi residu author unauthor prohibit pharmacolog activ substanc laboratori must also consid state art analyt methodolog perform requir current legisl aim work develop multiresidu method determin antibiot milk compliant criteria procedur establish commiss implement regul eu method use lc orbitrap hrms determin molecul antibiot activ antibacteri substanc belong differ chemic class beta lactam tetracyclin sulfonamid quinolon pleuromutilin macrolid lincosamid bovin ovin goat milk sampl provid simpl quick sampl pretreat subsequ identif phase analyt concentr equal lower maximum residu limit mrl complianc commiss regul eu valid paramet select stabil applic detect capabl cc agreement requir commiss implement regul eu demonstr effect method detect veterinari drug residu target screen concentr mrl level fals posit rate less method repres effect solut detect antibiot milk success appli routin analys offici food control plan | D015363;D019155 | T121;T109 |
36,234,694 | fluorin nitrogen codop carbon dot fluoresc switch probe select fe iii ascorb acid sens live cell high qualiti fluoresc probe base carbon dot cds promis applic mani field owe good stabil low toxic high quantum yield low raw materi price fluorin nitrogen dope fluoresc cds nfcds blue fluoresc success synthes use aminophenol difluorobenzo acid raw materi hydrotherm method nfcds probe use direct indirect detect fe detect rang detect limit ascorb acid aa detect rang detect limit nfcds base probe show except select strong anti interfer fe ascorb acid aa addit examin respons nfcds fe aa live cell show time use aa reduc effect iron poison import biolog signific mean use nfcds fluoresc probe benefici fe aa detect observ dynam chang live cell thus work may contribut studi fe aa relat diseas | D002244;D045663 | T121;T196;T073 |
36,234,692 | pasteur akkermansia muciniphila reduc fat accumul via nhr mediat nuclear hormon signal pathway caenorhabd elegan pasteur akkermansia muciniphila p akk relat lipid metabol help control obes main goal studi investig role mechan p akk lipid metabol use caenorhabd elegan result show p akk increas healthi lifespan nematod help maintain exercis abil age suggest potenti increas energi expenditur overal fat deposit triglycerid level signific decreas p akk anti oxid stress help regul fatti acid composit addit transcriptom result show p akk increas express lipo hydrolas fatti acid oxid relat gene includ lipl nhr ac acdh decreas express fat synthesi relat gene includ fat elo men result partial explain mechan under fact p akk decreas fat accumul c elegan via nhr ac mediat signal involv fatti acid oxid synthesi | D017173;D029742 | T116;T204 |
36,234,691 | caryophyllen therapeut altern intestin barrier dysfunct caus obes obes excess accumul fat exacerb metabol inflammatori process studi associ process condit dysregul intestin tract increas concentr lipopolysaccharid lpss blood differ abund intestin microbiota product secondari metabolit short chain fatti acid caryophyllen bcp natur sesquiterpen anti inflammatori properti potenti purpos fight metabol diseas diet induc obes model perform week old cbl mice administ bcp mgkg reduct express claudin observ group high fat diet hfd caus administr bcp besid bcp phyla akkermansia bacteroidet decreas group standard diet std vs hfd nevertheless use bcp std increas express phyla respect fatti acid similar effect observ hfd group decreas concentr restor use bcp level endotoxemia serum leptin increas hfd group hfd bcp group similar valu found std group attribut abil reduc condit obes | D005767;D012717;D012749 | T047;T109 |
36,234,690 | nanohybrid thymol simonkolleit enhanc inhibit bacteri growth biofilm format free radic due current concern opportunist pathogen challeng antimicrobi resist worldwid altern control pathogen growth requir sens work offer new nanohybrid compos zinc layer hydroxid salt simonkolleit thymol prevent bacteri growth materi character xrd diffract ftir uv vis spectra sem microscopi dynam light scatter confirm simonkolleit structur obtain thymol adsorb hydroxid web like manner concentr mg thymolmg znlhs absorpt kinet describ non linear model pseudo second order equat best fit antibacteri test conduct escherichia coli h staphylococcus aureus strain produc inhibit halo mm respect mgml solut thymol znlhs moreov biofilm format pseudomona aeruginosa inhibit test inhibit nanohybrid exhibit antioxid activ abt dpph evalu confirm presenc biomolecul inorgan matrix result use develop thymol protect vehicl applic food pharmaceut odontolog biomed industri | D000975;D013943 | T121;T109;T123;T044;T039 |
36,234,689 | effect limonen nanoemuls edibl film banana musa sapientum linn post harvest preserv limonen isopropenyl methylcyclohexen import compound sever citrus essenti oil orang lemon tangerin lime grapefruit use flavor agent food preserv agent general recogn safe gras status limonen well studi anti inflammatori antioxid anti cancer antibacteri properti antibacteri activ limonen food born pathogen investig studi prepar limonen nanoemuls limonen solut nanoemuls prepar six concentr v v respect antibacteri activ test four food born pathogen staphylococcus aureus listeria monocytogen salmonella enterica escherichia coli result show limonen nanoemuls good nanoscal overal particl size uniform particl size nm found limonen solut nanoemuls minim inhibitori concentr mgml could inhibit growth microorgan effici data indic limonen nanoemuls antibacteri abil microorgan limonen essenti oil banana treat limonen nanoemuls coat water loss banana storag percentag weight loss reduc inhibit activ pectinas applic biocoat provid good degre antibacteri activ air moistur barrier properti help extend shelf life banana | D002957;D000080122;D028521;D009822 | T109;T168;T073;T002 |
36,234,688 | chemoenzymat synthesi select intermedi natur product desferrioxamin e siderophor pathway nis synthetas famili enzym respons biosynthesi siderophor increas associ bacteri virul protein class repres outstand potenti drug target assum basic biochem structur character complet toward goal mate improv synthesi non commerci amino acid n hydroxi n succinylcadaverin hsc isotherm titrat calorimetri itc assay profil iter stage hsc trimer macrocycl nis synthetas desd streptomyc coelicolor hsc synthesi begin multigram scale gabriell tert butyl n benzyloxi carbam alkyl bromo chloropentan follow prior literatur end game report herein two advantag greater materi throughput hydrogenolysi benzyl ether cbz block group best accomplish pearlman catalyst psi h purif neutral zwitterion hsc effect simpl flash chromatographi silica gel meoh hsc subsequ shown substrat nis synthetas desd catalyz three success amid bond synthes via adenyl monophosph ester intermedi quantifi present iter overal enzym kinet constant associ format cyclotrimer siderophor desferrioxamin e dfoe | D001688;D017262 | T121;T109;T123 |
36,234,687 | protect effect polyphenol rich blueberri extract adult human neural progenitor cell age process impact neural stem cell caus signific declin neurogenesi contribut neuron dysfunct lead cognit declin blueberri rich polyphenol shown improv cognit memori older human previous studi shown blueberri supplement increas neurogenesi age rodent clear whether find extrapol human thus investig effect blueberri treatment adult hippocamp human neural progenitor cell ahnp involv neurogenesi potenti memori brain function cultur ahnp treat blueberri extract differ concentr viabil prolifer differenti evalu without presenc cellular oxid stressor dopamin potenti cellular mechan also investig data show blueberri extract signific increas viabil prolifer rate control hippocamp ahnp also revers decreas viabil prolifer induc cellular stressor dopamin effect may associ blueberri anti inflammatori antioxid calcium buffer properti polyphenol rich berri extract thus confer neuroprotect effect human hippocamp progenitor cell vitro | D029798;D058953;D018696 | T002;T121;T168;T169;T025 |
36,234,686 | structur activ relationship studi around db potent select inhibitor clk kinas three seri lead clk inhibitor db design synthet test clks dyrka kinas cytotox subsequ measur seven repres cancer cell line guid dock experi focus less constrain part scaffold show drastic differ substitu toler work end discoveri anoth promis deriv g ic inhibit hs clk ic inhibit hs dyrka sar result discuss light extens molecular model analys final kinom scan human kinas confirm outstand select lead compound db suggest scaffold promin interest select clk inhibitor altogeth result pave way develop inhibitor novel select famili kinas | D047428 | T121;T116 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.