PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,233,268 | role paraventricular coerulear network program hypertens prenat undernutrit crucial etiolog compon fetal program earli nutrit inde earli undernutrit may caus chronic increas blood pressur cardiovascular diseas includ stroke heart failur regard current evid sustain sever patholog mechan involv chang central peripher target present review summar neuroendocrin neuroplast modif underli maladapt mechan relat chronic hypertens program earli undernutrit first analyz role glucocorticoid mechan long term program hypertens second discuss patholog plastic chang paraventricular nucleus hypothalamus contribut develop chronic hypertens anim model prenat undernutrit dissect neural network reciproc communic nucleus locus coeruleus final propos integr updat view main neuroendocrin central circuit alter support occurr chronic increas blood pressur prenat undernourish anim | D006973;D044342;D011297 | T047;T037 |
36,233,267 | genom wide identif character express analysi tubbi like protein tlp gene famili member woodland strawberri fragaria vesca tubbi like protein tlps play import role plant growth develop respons abiot stress howev tlps strawberri remain poor studi studi eight tlp identifi woodland strawberri fragaria vesca subspeci vesca ruegen protein structur analysi reveal structur fvtlps high conserv evolutionari gene structur analys reveal evolutionari pattern fvtlp famili member differ ortholog gene arabidopsi poplar appl subcellular local assay reveal fvtlps local nucleus plasma membran fvtlps show transcript activ yeast two hybrid assay reveal fvtlps interact specif fvskps express pattern fvtlp differ tissu various abiot stress salt drought cold heat hormon treatment aba abscis acid meja methyl jasmon determin express pattern fvtlp indic play role regul growth develop respons abiot stress f vesca gus beta glucuronidas activ fvtlp pro gus plant gus activ assay increas salt drought stress abscis acid treatment result studi provid new insight molecular mechan under function tlps | D017360;D031985 | T168;T002 |
36,233,266 | effect modul lacosamid cumul inhibit na high frequenc stimul recoveri na block condit puls train effect lacosamid lcs vimpat anti convuls analges voltag gate na current na investig lcs suppress peak transient na sustain late na l compon na ic valu found gh cell neuro cell respect gh cell voltag depend hysteresi persist na na p triangular ramp puls strike attenu decay time constant na na l train depolar puls shorten lcs recoveri time cours na block elicit preced condit train fit two exponenti process singl exponenti increas current recoveri without condit train adequ fit fast slow recoveri na block condit protocol aros presenc lcs neuro cell strength instantan window na na w rapid ramp puls reduc lcs reduct could revers tefluthrin moreov lcs acceler inactiv time cours na activ puls train stimul veratridin revers decreas decay valu current inactiv dock result predict capabl lcs bind amino acid residu sodium channel owe occurr hydrophob contact overal find unveil lcs interact sodium channel alter magnitud gate voltag depend hysteresi behavior use depend na excit cell | D012964;D015222 | T034;T123;T116;T196 |
36,233,265 | adsorpt characterist hair dye remov aqueous solut onto oak cupul powder coat zno three hair dye arianor madder red r arian straw yellow arianor eboni e remov aqueous solut batch mode use powder oak cupul coat zno coz coz adsorb materi character term xrd ft ir sem analysi best condit uptak hair dye coz investig dye best uptak estim g coz ph min e dye uptak requir min g coz ph e hair dye kinet data reveal pseudo first order model e hair dye pseudo second order model r equilibrium data exhibit consist langmuir isotherm model adsorpt e dye onto coz freundlich isotherm model adsorpt r hair dye onto coz isotherm model r temkin also examin thermodynam paramet g h demonstr remov hair dye coz spontan endotherm feasibl adsorpt capac coz r e uptak found mgg respect furthermor coz reusabl demonstr five cycl regener neglig declin adsorpt extent r e respect comparison initi capac | D006202;D029963;D014874;D015034 | T002;T131;T120;T121;T197 |
36,233,264 | nobiletin prevent galactos induc cc cell age improv mitochondri function age associ loss skelet muscl mass function one main caus loss independ physic incapacit geriatr popul studi use galactos induc cc myoblast age model explor whether nobiletin nob could delay skelet muscl age determin associ mechan result show nob intervent improv mitochondri function increas atp product reduc reactiv oxygen speci ros product inhibit inflamm prevent apoptosi well age addit nob improv autophagi function remov misfold protein damag organell clear ros reduc mitochondri damag improv skelet muscl atrophi moreov result illustr nob enhanc mitochondri function also enhanc autophagi function protein synthesi pathway inhibit skelet muscl atrophi therefor nob may potenti candid prevent treatment age relat muscl declin | D005690;D008928 | T026;T043;T109;T123 |
36,233,263 | mircorna extracellular vesicl patient pulmonari arteri hypertens alter endotheli angiogen respons pulmonari arteri hypertens pah character progress elev pulmonari pressur lead right ventricular dysfunct associ poor prognosi patient pah increas number circul extracellular vesicl ev alter express circul microrna mir studi aim evalu mir profil contain within purifi ev deriv plasma pah patient compar healthi control hc circul ev purifi platelet free plasma analyz use flow cytometri western blot electron microscopi total rna isol ev subject microarray analysi use genechip mirna array bioinformat tool overexpress inhibit mir conduct human pulmonari arteri endotheli cell hpaec incub previous either pah hc deriv ev cell prolifer mtt assay angiogenesi tube format assay test hpaec determin mir function mir profil reveal heat compar pah hc group found regul regul pah ev among alter mir mir p overexpress mir p downregul pah ev compar hc ev inhibit mir p overexpress mir p hpaec post exposur pah ev abrog proangiogen prolif effect pose pah ev contrari hc ev angiogen prolif effect mir pah ev observ mediat nuclear factor nf b activ pah ev carri present alter mir profil target restrict angiogenesi reduc pulmonari endothelium activ studi concern mir circul heterogen ev pah patient warrant understand potenti target treatment pah | D000067128;D035683;D000081029 | T026;T123;T047;T114 |
36,233,262 | regul mesotheli cell fate develop human diseas mesotheli cell mcs play classic role maintain homeostasi pleural periton pericardi caviti mcs work lubric reduc friction organ regul fluid transport regul defens mechan inflamm mcs differenti various cell exhibit epitheli mesenchym characterist mcs high potenti differenti embryon period tissu develop activ potenti decreas adulthood express wilm tumor suppressor gene wt one mc marker decreas uniform signific embryon period adulthood suggest play major role differenti potenti mcs wt delet embryon period result embryon lethal mice even wt knockout adulthood lead death rapid organ atrophi find suggest mcs express wt high differenti potenti contribut format mainten various tissu embryon period adulthood properti mcs dynam transform characterist tumor microenviron cancer associ mcs review focus relationship differenti potenti mcs wt includ recent report use lineag trace use cre loxp system | D054327;D010994 | T023;T167;T024 |
36,233,261 | emerg role catenin famili member catulin develop homeostasi cancer progress catulin togeth vinculin catenin belong vinculin famili protein best known actin filament bind properti crucial role cell cell cell substrat adhes past year array bind partner catulin surfac shed new light possibl function protein despit inform molecular basi catulin act cell control wide varieti signal morphogenesi tissu homeostasi cancer progress remain elus review aim highlight recent discoveri catulin involv broad rang divers biolog process emphasi cancer progress | D051177;D009369 | T191;T123;T116 |
36,233,260 | synergist antivir effect metal oxid carbon nanotub research synergist antivir effect carbon nanotub cnts metal oxid mo form novel hybrid structur mo cnts present raw cnts ni oh fe mno well ni oh cnt fe cnt mno cnt explor studi escherichia coli ms bacteriophag use virus surrog nano particl synthes character use field emiss scan electron microscopi fesem energi dispers x ray spectroscopi ed transmiss electron microscopi tem particl size analysi fourier transform infrar spectroscopi ftir x ray diffract xrd kinet paramet ld lethal dose kill popul time taken kill popul sgr specif growth rate ird initi rate deactiv popul also studi examin antivir efficaci nanomateri among nanomateri ni oh cnt effect antivir agent follow fe cnt mno cnt raw cnts ni oh fe mno compar metal oxid cnts raw cnts averag enhanc averag antivir activ enhanc mo cnts higher mo compar raw cnts averag enhanc mo cnts kinet studi show ld ni oh cnt lowest gml impli toxic compound studi ld ni oh fe mno time greater correspond hybrid cnts synergist mechan involv entrap phage virus nano structur cnts lead structur damag along toxic phage releas mo ion metal oxid cnt nano hybrid develop project promis candid applic antivir coat nanocomposit adsorb compon person protect gear | D037742 | T104;T073 |
36,233,259 | clone molecular character hsp gene anoplophora glabripenni respons cold stress anoplophora glabripenni agla import global quarantin pest due high destruct impact forest wide distribut mani countri asia europ north america surviv glabripenni larva facilit high adapt low temperatur insect subject temperatur stress heat shock protein hsps limit cell damag improv cell toler via protein fold local degrad activ howev temperatur adapt mechan glabripenni hsps remain unclear studi four glabripenni hsp gene aglahsp aglahsp aglahsp aglahsp clone sequenc analysi show four hsps specif conserv domain phylogenet analysi reveal hsps differ subfamili evolutionarili conserv aglahsp high similar coleoptera speci protein express vector peta aglahsp construct use express aglahsp e coli four protein express inclus bodi western blot analysi show aglahsp express rang temperatur c c aglahsp aglahsp show high express treatment c result facilit clarif molecular mechan under glabripenni respons environment stress | D058639;D001517 | T040;T204 |
36,233,258 | schedul depend treatment increas chemotherapi efficaci malign pleural mesothelioma malign pleural mesothelioma mpm rare aggress thorac malign limit treatment option one standard treatment mpm chemotherapi consist concurr treatment pemetrex cisplatin pemetrex limit tumor growth inhibit critic metabol enzym involv nucleotid synthesi cisplatin caus direct dna damag intra strand inter strand cross link repair nucleotid excis repair pathway depend relat high nucleotid level hypothes prolong pretreat pemetrex might deplet nucleotid pool therebi sensit cancer cell subsequ cisplatin treatment mpm cell line acc meso nci h treat h pemetrex three treatment schedul evalu initi h cisplatin treatment h concomit h h relat pemetrex treatment result either concomit administr pemetrex pretreat h h respect multicolor flow cytometri perform detect hax phosphoryl histon hax surrog marker activ dna damag respons pathway dapi stain dna use analyz cell cycl distribut forward side scatter intens use distinguish subpopul base cellular size granular respect studi reveal prolong pemetrex pretreat h prior cisplatin signific reduc long term cell growth specif pretreat h pemetrex induc cell cycl arrest main gm phase accumul persist dna damag induct senesc phenotyp present studi demonstr optim treatment schedul pretreat pemetrex increas efficaci pemetrex cisplatin combin therapi mpm show observ benefit associ persist treatment induc dna damag studi suggest adjust treatment schedul could improv efficaci standard chemotherapi regimen mpm might improv patient outcom | D008175;D008654;D000086002;D010997 | T191 |
36,233,257 | myoton dystrophi molecular pathogenesi therapeut current studi concern myoton dystrophi type dm process transit molecular investig preclin clinic trial | D009223 | T047 |
36,233,256 | role androgen human biolog metabol regul health androgen import divers group steroid hormon molecular speci play vari function role control metabol energi fate partit mainten skelet bodi protein integr develop brain capabl behavior setup includ factor defin male addit androgen precursor estrogen share extens control reproduct mechan sex review type androgen function signal tabul describ includ less known function close interrelationship corticosteroid androgen also analyz center adren cortex togeth main feedback control system hypothalam hypophysi gonad axi modul metabol environ sex age health testosteron singl high synthesi rate turnov also age relat hypogonad key signal biolog plan earli obsolesc men delay onset faster rate function loss women menopaus close collabor estradiol e activ mainten bodi metabol system also present parallel insuffici direct relat ravag senesc metabol syndrom constel disord clinic use correct hypoandrogen help maintain function core metabol limit excess fat deposit sarcopenia cognoscit frailti part effect due e generat effect use lipophil ester replac treatment analyz depth main problem deriv applic discuss | D000728;D013739 | T121;T109;T125;T039 |
36,233,255 | high effici reduc strain produc selenium nanoparticl isol marin sediment selenium nanoparticl senp import research exhibit higher degre absorpt lower toxic organ inorgan form present report marin strain reduc se iv generat se studi strain reduc sodium selenit senp high effici screen marin strain senp produc whole cell senp e produc extracellular extract character ftir uv raman xrd sem base result two kind senp exhibit obvious differ morpholog surfac cap differ biomacromolecul due differ shape surfac coat opposit result obtain antibacteri activ senp senp e gram posit gram negat bacteria senp senp e exhibit obvious cytotox concentr gml senp e retain lower cytotox concentr increas gml first report detail differ senp produc whole cell cell extract | D053758;D012643 | T121;T123;T073;T196 |
36,233,254 | first evid bacteri foci hair part dermal papilla scalp hair follicl pilot compar studi alopecia areata role microbiom hair follicl hf growth repres grow field research studi bacteri popul scalp hair follicl subject alopecia areata aa two healthi two aa subject respect year old enrol studi regard microbi communiti subepiderm scalp compart mean mm biopsi punch sampl examin sequenc histochem stain gram method transmiss electron microscopi tem bacteri foci observ aa subject follicl two adopt complementari approach electron microscopi gram stain signific p lt differ also found three layer biopsi sampl p lt regard bacteri popul particular deep epidermi dermi level signific p lt lower abund firmicut higher abund proteobacteria found aa sampl compar healthi control firmicut also show signific p lt lower abund hypodermi aa subject addit enterobacteriacea genera streptococcus gemella porphyromona granulicatella relat abund aa group deep epidermi level staphylococcus flavobacterium genera signific less abund aa sampl control three layer biopsi sampl p lt contrast veillonella neisseriacea relat abund healthi control group compar aa sampl therefor higher alpha divers observ three layer biopsi sampl aa patient compar control conclus data suggest taa could defin hair diseas associ dysregul microbiom immun axi hair follicl | D000506;D064307 | T001;T047;T032;T028 |
36,233,253 | influenc il tgfb promot polymorph serum cytokin level develop sever ra studi focus role immunosuppress cytokin tgf il ra particular influenc il ag rs tgfb ct rs promot polymorph level prerequisit ra diseas activ clinic featur found signific higher il lower tgf serum level women ra control patient carri aa ag genotyp signific higher level lnil compar gg contrast healthi women carri genotyp heterozyg ag genotyp less frequent ra case healthi women could protect factor ra develop domin model ci addit ra patient carri heterozyg ag genotyp less like anti ccp posit carri homozyg aagg genotyp vs ci p associ tgfb ct snp suscept ra relat system tgf level rs genotyp conclus il genotyp affect serum level il women ra differ way healthi women appear play role genet predisposit autoantibodi product bulgarian popul | D001172;D016753;D053773 | T047;T116;T121;T123;T129 |
36,233,252 | sphingolipid atherosclerosi chimera structur function atherosclerosi system inflammatori diseas number one caus mortal morbid worldwid prevent diseas progress global interest order reduc annual death signific scale atherosclerosi character plaqu format arteri result vascular event ischem stroke myocardi infarct better understand under pathophysiolog process cellular molecular level indispens identifi novel therapeut target may allevi diseas initi progress sphingolipid lipid class name chimer creatur sphinx consid play critic metaphor equal chimer regulatori role atherogenesi previous studi identifi six common sphingolipid name dihydroceramid dhcer ceramid cer sphingosin phosphat sp sphingomyelin sm lactosylceramid laccer glucosylceramid glucer carotid plaqu demonstr potenti induc plaqu inflamm review point specif role atherosclerosi focus differ cell type carrier molecul enzym receptor involv atherogenesi wherea assum main atheroprotect effect glucer laccer sphingolipid dhcer cer sm sp mediat chimer function initi studi demonstr success use intervent sphingolipid pathway prevent atherosclerosi howev atherosclerosi multifactori diseas varieti under cellular process imper futur research emphas circumst sphingolipid exert protect progress function evalu therapeut benefit spatiotempor manner | D050197;D058226 | T031;T047;T046;T020 |
36,233,251 | antibacteri activ allicin inspir disulfid deriv xanthomona amp nbsp axonopodi pv citri xanthomona axonopodi pv citri xac belong gram negat speci caus citrus canker serious affect fruit yield qualiti mani rutacea plant herein found compound butyldisulfanyl quinazolin h one exhibit remark anti x ac activ vitro half effect concentr ec gml posit control thiodiazol copper gml bismerthiazol gml compound show great anti citrus canker activ vivo activ compound also confirm reduc biofilm format increas level reactiv oxygen speci damag morpholog structur bacteria caus bacteri death proteom rt qpcr analysi result indic compound regul express enzym mep methyl erythritol phosphat pathway might achiev destruct abil xac overal studi indic deriv could promis scaffold develop novel bactericid control citrus canker | D002957;D014974;D053532 | T007;T168;T002 |
36,233,250 | famili linkag associ nrc gene type diabet depress comorbid impair hypothalam pituitari adren hpa axi cortisol pathway may major contribut factor common pathogenesi major depress disord mdd type diabet td signific player neuroendocrin hpa axi cortisol respons glucocorticoid receptor gr encod nuclear receptor subfamili group c member nrc gene variant nrc gene report patient mdd obes found confer reduc risk quantit metabol trait td cush syndrom variant report td mdd td comorbid patient studi origin italian famili rich famili histori td test singl nucleotid polymorph snps nrc gene linkag linkag disequilibrium ld td mdd across differ inherit model identifi total novel snps signific linkedin ld towith td rs rs rs rs rs rs snp rs signific link toin ld td mdd find expand understand role nrc variant play modul risk td mdd comorbid replic function studi need confirm find | D003865;D003924;D011965 | T047;T116;T048;T192 |
36,233,249 | novel insight floral thermogenesi vivo analys mitochondri dynam nelumbo nucifera flower anim like thermogen tm activ flower report sever famili seed plant associ mitochondria floral thermogenesi describ mitochondri dynam involv regul floral thermogenesi unclear studi morpholog function dynam mitochondria vivo assess nelumbo nucifera gaertn flower floral thermogenesi result show mitochondri biogenesi increas consider n nucifera flower thermogenesi accompani notabl morpholog chang mitochondria includ long ellipt rod shape dumbbel shape morpholog well increas mitochondri reactiv oxygen speci ros level tm cell increas express altern oxidas aox thermogenesi n nucifera flower also observ observ suggest rapid chang mitochondri morpholog increas densiti thermogenesi impli activ mitochondri fission combin elev level mitochondri ros trigger substanti increas aox within respiratori pathway tm n nucifera | D031653 | T002 |
36,233,248 | novel small molecul btb inhibit pro fibrot fibroblast behavior though inhibit rhoa activ idiopath pulmonari fibrosi ipf progress chronic interstiti lung diseas poor prognosi although specif anti fibrot medic avail median surviv time follow diagnosi remain low new therapi urgent need uncov novel therapeut target examin biochem properti fibrot lung differ healthi lung previous work identifi lactat metabolit upregul ipf lung tissu import inhibit enzym respons lactat product prevent fibrosi vivo studi reveal fibrot lesion lung experi signific declin tissu ph like due overproduct lactat entir clear cell lung respond chang extracellular ph famili proton sens g protein coupl receptor shown activ reduct extracellular ph work examin express profil proton sens gpcrs non fibrot ipf deriv primari human lung fibroblast identifi tdag proton sens gpcr upregul ipf fibroblast knockdown tdag dampen myofibroblast differenti surpris btb propos posit alloster modul tdag inhibit myofibroblast differenti data suggest btb requir tdag inhibit myofibroblast differenti rather inhibit myofibroblast differenti suppress rhoa mediat signal work highlight therapeut potenti btb anti fibrot treatment expand upon import rhoa mediat signal pathway context myofibroblast differenti furthermor work also suggest tdag inhibit may therapeut relev treatment ipf | D054990;D020742 | T047;T126;T116 |
36,233,247 | vitroin vivo translat synergist combin mdm mek inhibitor melanoma use pbpkpd model part ii develop vitroin vivo translat method synergist act drug combin need identifi effect therapeut strategi perform pbpkpd model siremadlin trametinib combin various dose level dose schedul xenograft mous model melanoma cell studi built model base vitro adm vivo pkpd data determin literatur estim simcyp anim simul v develop pbpkpd model allow us account interact siremadlin trametinib pk pd level interact pk level describ interplay absorpt tumour disposit level wherea pd interact base vitro result approach allow us reason estim synergist efficaci dose schedul dose level combin siremadlin trametinib mice pbpkpd model power tool allow research proper estim vivo efficaci anticanc drug combin base result vitro studi approach base vitro vivo extrapol may help research determin efficaci dose strategi allow extrapol anim pbpkpd model clinic set | D008545;D020929;D051736 | T191;T126;T116;T123 |
36,233,246 | lactat lactyl hand metabol reprogram immunosuppress immun evas metabol reprogram two fundament hallmark cancer interest lactat close link togeth howev lactat long recogn metabol wast product lactat acidif tumor microenviron tme promot key carcinogenesi process includ angiogenesi invas metastasi immun escap notabl histon lysin lactyl kla identifi novel post modif ptm provid new perspect mechan lactat function provid promis potenti therapi tumor target studi confirm protein lactyl essenti lactat function involv import life activ glycolysi relat cell function macrophag polar review systemat elucid role lactat immunosuppress molecul aspect lactat metabol effect histon lysin non histon lactyl immun cell provid new idea understand protein lactyl elucid lactat regul cell metabol immun function explor possibl target potenti target lactat metabol cancer treatment final promis propos combin strategi inhibit glycolyt pathway immunotherapi | D007153;D009369 | T191;T047 |
36,233,245 | intratumor treatment androsten diol reduc tumor size lung metastasi tripl negat experiment model breast cancer breast cancer treatment failur relat low respons rate high cost long term toxic thus necessari find less toxic cheaper effect treatment situ administr ensur drug deliveri tumor cell decreas system toxic effect androsten diol a reduc breast tumor cell prolifer ideal candid treat mammari tumor studi aim identifi vitro vivo effect a tripl negat mammari tumor model vitro biphas steroid effect observ mous human mammari tumor cell treat a sens cell treat higher dose show antiprolif effect a administr intratumor reduc averag tumor weight increas percentag natur killer cell nk plasmat plasmablast cell mice tumor note vegf level a treat tumor lower control vehicl group tumor situ increas respons reflect system higher anti igg concentr serum a treat mice associ system chang detect reduct tumor size local inject a associ anti prolif effect steroid lower local level vegf may relat impercept macroscop metastasi a treat mice suggest a may use clinic studi prove efficaci altern breast tumor treatment conjunct alreadi establish therapi | D001943;D008175 | T191 |
36,233,244 | divers biolog activ endophyt fungi flower medicin plant vernonia anthelmintica secondari metabolit produc endophyt fungi import sourc biolog activ compound current research focus biolog activ ethyl acet extract fungi isol identifi vernonia anthelmintica flower first time addit investig non polar chemic composit dichloromethan ethyl acet extract activ fungal strain carri isol includ ovatospora senegalensi nr chaetomium globosum nr thielavia subthermophila nr aspergillus calidoustus nr aspergillus keveii xjf aspergillus terreus xjf speci strain identifi rrna gene sequenc method regist genbank crude extract fungi display vitro biolog activ includ antimicrobi cytotox activ melanin content assay perform murin b cell ethyl acet extract senegalensi nr show high anticanc antimicrobi activ therefor also studi non polar chemic composit dichloromethan ethyl acet fraction identifi non polar compound differ medium investig discov secondari metabolit total extract endophyt fungi could potenti sourc altern natur antimicrobi cytotox melanin synthesi activ host plant isol bioactiv metabolit may provid lead new compound pharmaceut signific | D000890;D010946;D035741 | T121;T002 |
36,233,243 | diflubenzuron induc cardiotox zebrafish embryo diflubenzuron insecticid serv chitin inhibitor restrict growth mani harm larva includ mosquito larva cotton bollworm fli residu diflubenzuron often detect aquacultur potenti toxic aquat organ still obscur studi zebrafish embryo h h post fertil hpf expos differ concentr diflubenzuron mgl morpholog chang mortal rate hatchabl rate averag heart rate calcul diflubenzuron exposur increas distanc venous sinus bulbar arteri sv ba inhibit prolifer myocardi cell damag vascular develop addit diflubenzuron exposur also induc content reactiv oxygen speci ros malondialdehyd mda inhibit activ antioxid includ sod superoxid dismutas cat catalas moreov acridin orang ao stain show diflubenzuron exposur increas apoptot cell heart q pcr also indic diflubenzuron exposur promot express apoptosi relat gene bax bcl p caspas caspas howev express heart relat gene inhibit oxid stress induc apoptosi damag cardiac develop zebrafish embryo therefor diflubenzuron exposur induc sever cardiotox zebrafish embryo result contribut comprehens understand safeti use diflubenzuron | D004132;D007306;D014874 | T121;T109;T131 |
36,233,242 | caspas cleav caspas express tumorogenesi correl prognosi head neck cancer systemat review meta analysi head neck cancer hnc ascend agress diseas search new molecular marker emerg solv difficulti diagnosi risk manag prognosi effect treatment protein relat apoptot machineri identifi potenti biomark caspas main effector caspas key role apoptosi object systemat review meta analysi review studi analyz chang caspas cleav caspas express oral premalign disord opmd well head neck cancer hnc studi also propos review prognost valu associ hnc accord express caspas medlin via pubm embas scopus cochran web scienc grey literatur databas screen incept june studi select includ prognost meta analysi result relat comparison caspas express demonstr similar express caspas hnc averag show highmoder express compar opmd interest cleav caspas result incres hnc compar opmd versus pool fix effect hr valu ci os relat caspas ihc express hnc patient ci also rate heterogen low reveal dfs ci dss show hr ci caspas cleav caspas express could link malign progress express caspas influenc prognosi patient hnc | D053148;D006258 | T191;T126;T116 |
36,233,241 | identif drug induc liver injuri biomark multipl microarray base machin learn bioinformat analysi drug induc liver injuri dili common advers effect numer drug lead caus drug withdraw market recent year incid dili increas howev diagnos dili remain challeng lack specif biomark henc use machin learn ml mine multipl microarray identifi use gene could contribut diagnos dili prospect studi screen six elig microarray gene express omnibus geo databas first differenti express gene deg identifi train set subsequ function enrich analysi deg perform use six ml algorithm identifi potenti use gene base receiv oper characterist roc four gene ddit gadda slca rbm identifi averag valu area curv auc four gene higher train test set addit result immun cell correl analysi show four gene high signific correl multipl immun cell studi reveal ddit gadda slca rbm could biomark contribut identif patient dili | D056486;D019295 | T047;T091;T037 |
36,233,240 | defect epigenet reprogram dox depend porcin ipsc porcin induc pluripot stem cell pipsc great signific anim breed human medicin howev import problem mainten pipsc main depend exogen express pluripot transcript factor tfs germlin transmiss compet pipsc yet success establish studi explor defect epigenet reprogram pipsc format includ chromatin access dna methyl imprint gene express high throughput sequenc atac seq wgbs rna seq seq method found somat featur success silenc connect close chromatin loci downregul gene dna methyl limit effect somat silenc howev incomplet chromatin remodel dna demethyl pluripot gene hinder pluripot activ result low express endogen pluripot gene addit express potenti imprint gene abnorm mani allel bias express gene porcin embryon fibroblast pef eras accompani establish new allel bias express gene pipsc studi reveal aberr epigenet reprogram dox depend pipsc format lay foundat research porcin ipsc reprogram genom imprint | D057026;D039904 | T025 |
36,233,239 | genom wide identif express profil analysi long chain acyl coa synthetas reveal potenti role wheat male fertil long chain acyl coa synthetas lac respons convers free fas acyl coa involv multipl pathway lipid metabol although lac gene arabidopsi well character detail inform concern famili avail wheat present studi systemat analysi carri wheat lac famili result putat talacss identifi express analysi reveal takac express wheat anther two ortholog atlac talac talac repress vacuol stage cold treat bs temperatur sensit genic male steril line thus talac talac may function like atlac wax biosynthesi anther repress gene may correl male steril bs talac ortholog atlac express exclus anther talac repress cold treat bs tetrad uninucl vacuol stage negat correl talac tagamyb b myb domain found promot sequenc suggest talac may negat regul tagamyb b particip wheat fertil find provid valuabl foundat understand wheat lac gene famili male fertil | D017360;D014908 | T168;T002 |
36,233,238 | role virul factor neonat sepsi caus enterobacteral systemat review neonat sepsi life threaten condit high mortal virul determin relev caus gram negat gn neonat sepsi still poor character better understand virul factor vfs associ gn neonat sepsi could offer new target therapeut intervent aim review assess role gn vfs neonat sepsi primarili aim investig main vfs lead advers outcom second evalu vfs associ increas invasivenesspathogen neonat medlin embas cochran librari systemat search studi report data role virulomevf bloodstream infect caus enterobacteral among neonat infant age day twenti studi fulfil inclus criteria studi report data associ pathogen virul determin neonat mortal wherea studi includ secondari analys qualiti report suboptim great major publish studi consist associ virul determin gn strain caus neonat sepsi identifi consider heterogen found term vfs analys report includ popul microbiolog method includ studi often show conflict data variabl hamper comparison result conclus pathogen respons neonat sepsi wide heterogen use differ pathway develop invas diseas recent genom wide approach need includ multicentr studi larger sampl size analys vf gene profil instead singl vf gene alongsid comprehens collect clinic inform better understand role virul gene neonat gn bacteraemia may offer new vaccin target new marker high virul strain inform potenti use screen prevent intervent well new target anti virul antibiot spare therapi | D016470;D020563;D016905;D000071074;D018805 | T007;T047;T046 |
36,233,237 | psoriasi microdamag sixth sens neurocentr view psoriasi consid multifactori heterogen system diseas mani under patholog mechan elucid howev pathomechan far entir known opinion articl demonstr potenti relev somatosensori piezo microinjuri induc quad phasic non contact injuri model psoriasi multidisciplinari approach primari injuri suggest piezo contain somatosensori affer termin merkel cell neurit complex concomit impair glutam vesicular releas machineri merkel cell part theori merkel cell neurit complex contribut propriocept henc stretch skin piezo channelopathi could result imbalanc control piezo keratinocyt cluster manner lead dysregul keratinocyt prolifer differenti furthermor author propos role mthsp leakag damag mitochondria somatosensori termin initi autoimmun autoinflammatori process psoriasi secondari phase harsher epiderm tissu damag due primari impair propriocept third injuri phase refer injuri sensit derail heal state part wound heal perman amp nbsp kept aliv due genet predisposit environment risk factor final quadric damag phase associ age process associ inflammag summari opinion piec postul primari microinjuri sixth sens piezo channelopathi somatosensori termin contribut propriocept could princip gateway patholog due encroach preprogram genet encod | D053447;D011565 | T047 |
36,233,236 | pink phosphoryl drp improv mitochondri fission inhibit progress hypertens induc hfpef background heart failur preserv eject fraction hfpef major subtyp hf effect treatment mitochondri dysfunct relev imbal fusion fission occur hfpef drp key protein regul mitochondri fission pink upstream activ drp relationship hf clarifi aim studi investig molecular mechan mitochondri dysfunct anim hypertens induc hfpef method result hypertens induc hfpef model establish feed dahlss rat high salt show risk factor hypertens mitochondri dysfunct physiolog biolog measur show decreas express mitochondri function relat gene atp product mitochondri fission index pink knockout hc cardiomyocyt show similar effect moreov pink myocardium specif overexpress activ drp phosphoryl enhanc mitochondri fission slow progress hypertens induc hfpef conclus pink could phosphoryl drps improv mitochondri fission reliev mitochondri dysfunct highlight potenti treatment hfpef | D034281;D006333;D006973;D011494 | T047;T046;T116;T126;T123 |
36,233,235 | fine regul hippocamp thyroid signal protect hypothyroid mice glial cell activ adult onset hypothyroid associ learn cognit dysfunct may relat alter synapt plastic local reduc level thyroid hormon ths may impair glia morpholog activ promot increas pro inflammatori cytokin level main hippocampus given neuroinflamm induc memori impair hypothyroid relat glia dysfunct may particip brain disord thus investig mechan link hypothyroid neuroinflamm protect perspect induc hypothyroid adult cblj wild deriv wsbeij male mice seven week propylthiouracil ptu treatment previous show wsbeij mice resist high fat diet hfd induc obes show neuroinflammatori respons adapt abil unlik cblj ptu hfd treatment known induc compar inflammatori respons hypothes wsbeij mice might also protect hypothyroid induc neuroinflamm show hypothyroid wsbeij mice depict hippocamp neuroinflammatori respons abl maintain hippocamp thyroid signal despit low circulatisng th level contrast cblj mice exhibit disturb hippocamp th signal accompani neuroinflamm memori impair result reinforc preponder hippocamp th regulatori system th circul level hippocamp glial reactiv | D007037;D011441 | T121;T047;T114 |
36,233,234 | longitudin assess multipl immunolog inflammatori paramet success daa therapi hcv monoinfect hivhcv coinfect subject direct act antivir daa era import understand immunolog chang hcv erad hcv monoinfect mhcv hivhcv coinfect hivhcv patient studi analyz sub popul monocyt dendrit cell dcs lymphocyt inflammatori biomark follow initi daa mhcv hivhcv patient effect antiretrovir therapi baselin sustain virolog respons week svr fifteen age sex match healthi donor hd enrol control group activ cd cd lymphocyt mdcs pdcs mdc classic non classic intermedi monocyt detect use flow cytometri ip scd scd assess elisa matrix metalloproteinas mmp measur zymographi baselin increas level ip scd mmp found hivhcv mhcv patient compar hd wherea scd increas hivhcv patient therapi ip scd scd decreas wherea mmp persist elev baselin activ cd cell high hivhcv mhcv patient compar hd decreas svr hivhcv patient activ cd cell higher hivhcv patient without modif daa therapi result suggest complex interact virus immun system partial revers daa treatment | D060085;D015658;D019698 | T047 |
36,233,233 | long last nociplast pain modul repeat administr sigma receptor antagonist bd fibromyalgia like mous model sigma receptor r ligand shown effect reliev neuropath inflammatori pain yet test experiment model fibromyalgia object studi evalu effect r antagonist bd compar pregabalin icr cd femal mice subject either six repeat inject reserpin caus reserpin induc myalgia rim acidifi salin intramuscular inject asi two model evalu effect bd pregabalin thermal hypersensit anxieti like depress like behavior spinal cord gliosi bd exert antinocicept effect reflex thermal hyperalgesia nonreflex anxieti depress like pain behavior reduc spinal astrogli microgli reactiv follow repeat treatment week interest effect bd long term last sever week treatment discontinu fibromyalgia like model similar result obtain pregabalin effect pain behavior last shorter length time pregabalin signific modul spinal glial reactiv inhibitori long last effect pharmacolog blockad rs sensori affect dimens nociplast like pain spinal cord gliosi two experiment model fibromyalgia support applic therapeut strategi treat fibromyalgia | D000700;D059350;D005356;D017480 | T047;T116;T192;T131;T121;T109;T123;T184 |
36,233,232 | promyelocyt leukemia protein potent restrict human cytomegalovirus infect endotheli cell pml nuclear bodi pml nbs dynam macromolecular complex mediat intrins immun virus differ famili includ human cytomegalovirus hcmv upon hcmv infect pml nbs target viral genom enter nucleus restrict viral immedi earli gene express epigenet silenc studi sever group perform human fibroblast cell shown major pml nb compon pml daxx sp atrx contribut repress cooper manner role hcmv restrict endotheli cell howev yet character although infect endothelium thought play crucial role hcmv dissemin develop vascular diseas vivo use condit immort umbil vein endotheli cell hec ltt cell cultur model elucid impact pml nb protein lytic hcmv infect deplet individu pml nb protein lentivir transduct show particular strong antivir effect pml hec ltt compar human fibroblast closer character antivir function reveal pml may effect inhibit hcmv immedi earli gene express also act later step viral replic cycl contrast surpris note antivir behavior daxx complementari approach deplet daxx result decreas viral gene express overexpress daxx promot hcmv infect summari data demonstr cell type specif effect pml nb compon lytic hcmv infect suggest import role pml inhibit hcmv dissemin infect endotheli cell | D003586;D006566;D000071156 | T047;T116 |
36,233,231 | liver graft proteom reveal potenti incipi mechan behind earli renal dysfunct liver transplant acut kidney injuri aki frequent liver transplant lt correl later develop chronic kidney diseas etiolog multifactori combin pre intra postop factor addit liver graft seem import element develop aki yet detail mechan remain unclear hypothes graft lt recipi develop signific earli aki may show distinct proteom alter set identifi proteom differ lt recipi develop moder sever aki n lt recipi without earli renal injuri n liver biopsi obtain one hour reperfus assess histolog use quantit proteom sever cytokin serum amyloid saa analyz serum sampl obtain preoper h h graft reperfus respect lt induc mild histolog alter without signific differ group uniform alter liver function test peak postop day trend toward sever alter patient develop aki global quantit proteom analysi reveal protein differ signific express level p lt fc protein higher lower level aki group protein relat immun inflammatori respons host defens neutrophil degranul differ studi pro anti inflammatori cytokin saa group found moment result suggest graft lt patient develop earli aki reveal distinct proteom domin earli yet promin activ innat immun find support hypothesi aki lt may favor certain graft characterist | D058186;D016031 | T061;T047;T037 |
36,233,230 | function heterogen bone marrow mesenchym stem cell subpopul physiolog patholog bone marrow mesenchym stem cell bmscs multi potent cell popul capabl maintain bone bodi homeostasi stem potenti therapeut effect bmscs explor extens recent year howev divers cell surfac antigen complex gene express bmscs indic bmscs repres heterogen popul natur characterist bmscs make difficult identifi specif subpopul patholog process often obscur bulk analysi total bmscs meanwhil therapeut effect total bmscs often less effect part due heterogen therefor understand function heterogen bmsc subpopul differ physiolog patholog condit could major ramif global health summar recent progress function heterogen bmsc subpopul physiolog patholog target tissu resid singl bmsc subpopul offer potenti innov therapeut strategi improv bmsc effect clinic applic | D045164;D059630 | T061;T025 |
36,233,229 | structur electron effect interfac transit metal dichalcogenid monolay mos wse later heterojunct liquid water transit metal dichalcogenid tmdcs use optic energi convers materi catalyz water split reaction good catalyt perform requir well match semiconductor bandgap water redox potenti fluent energi transfer ii optim orient water molecul interfac kinet fast chemic reaction interact solid liquid interfac import impact two factor theoret studi employ semiconductor vacuum model work explor interfac form liquid water differ type tmdcs monolay mos wse later heterojunct use combin molecular dynam md densiti function theori dft approach strong interact water semiconductor confin adsorb water layer present structur pattern water molecul well connect bulk water hydrogen bond network structur fluctuat metal chalcogenid bond md simul result ev reduct band gap tmdcs result suggest design new tmdc semiconductor surfac hydrophob variat bandgap origin water semiconductor interfac need consid | D008982;D028561 | T123;T196 |
36,233,228 | nucleotid induc nanoscal chang mechan properti rat cerebellar astrocyt select stimul block purinerg receptor px member famili nucleotid receptor px receptor particular interest due uniqu structur pharmacolog characterist atp gate ionic channel px receptor activ elicit membran depolar extracellular calcium influx activ sever downstream intracellular signal pathway independ ionic channel activ interact px receptor cytoskeleton relat protein also confirm previous describ effect px receptor stimul morpholog rat cerebellar astrocyt present work use time laps video microscopi atom forc microscopi afm elucid effect px receptor stimul morpholog migratori capabl mechan properti rat cerebellar astrocyt vitro stimul px receptor select agonist bzatp specif caus increas cell size motil number membran protrus astrocyt cultur effect revert cell previous treat competit antagonist pxr afm analysi also show increas cell stiff viscos px receptor stimul surpris effect mechan properti cell block treatment antagonist fluoresc microscopi analysi actin cytoskeleton show increas actin stress fiber bzatp treatment effect block previous treatment antagonist confirm effect px receptor cytoskeleton astrocyt least part independ ionic channel activ | D001253;D009711 | T025;T114 |
36,233,227 | time effect therapi import determin surviv bloodstream infect caus vancomycin resist enterococcus spp enterococc bloodstream infect ebsi caus vancomycin resist enterococci vre associ signific rate unfavor outcom definit data report associ delay antibiot therapi mortal prospect observ studi three larg hospit itali august april consecut hospit patient confirm diagnosi hospit acquir monomicrobi bsi caus vre evid endocard analyz cox regress analysi show risk factor independ associ day mortal age hr ci p chronic kidney diseas hr ci p oncolog diseas hr ci p intens care unit admiss hr ci p lt convers earli effect therapi associ surviv hr ci p lt administr earli effect antibiot therapi within h blood cultur collect associ day mortal rate lower time blood cultur collect appropri therapi independ predictor day mortal patient ebsi caus vre base data clinician start effect antibiot therapi soon possibl prefer within first h blood cultur collect treatment strategi allow earli deliveri vitro activ antibiot urgent need especi critic ill patient risk vre bacteremia | D016470;D016908;D065507 | T007;T047 |
36,233,226 | design synthesi biolog evalu neocryptolepin deriv potenti anti gastric cancer agent natur product play import role drug develop lead compound synthesi neocryptolepin polycycl quinolin compound isol cryptolepi sanguinol cytotox neocryptolepin gastric cancer cell ag mkn hgc sgc strong also certain toxic gastric mucosa cell ges therefor seri neocryptolepin deriv synthes modif structur neocryptolepin cytotox evalu result show compound c c exhibit strong cytotox ag cell cell coloni format cell migrat experi suggest compound c c could inhibit prolifer cell migrat ag hgc cell cell cycl apoptosi experi show compound c c caus apoptosi ag hgc cell main caus cell necrosi compound c signific effect ag hgc cell cycl low concentr treatment ag cell h high concentr compound c could signific arrest ag cell cycl gm phase compound c signific effect ag hgc cell cycl result molecular dock western blot show compound c c might induc cytotox pikakt signal pathway therefor compound c c may promis lead compound treatment gastric cancer | D000970;D001688;D011804;D013274 | T121;T109;T123;T191 |
36,233,225 | spontan occurr various type hepatocellular adenoma liver metabol syndrom associ steatohepat model tsod mice male tsumura suzuki obes diabet tsod mice spontan metabol syndrom model develop non alcohol steatohepat liver tumor feed standard mous diet near liver tumor express glutamin synthetas gs marker hepatocellular carcinoma contrast approxim gs negat without promin nuclear structur atypia studi examin characterist gs negat tumor tsod mice twenti male tsod mice sacrif week total tumor analyz stain immunostain gs liver fatti acid bind protein l fabp serum amyloid saa beta catenin immunostain gs six tumor negat base histolog immunohistolog characterist six gs negat tumor classifi sever subtyp human hepatocellular adenoma hca one larg tumor show general similar find inflammatori hca contain small atyp foci gs stain partial nuclear beta catenin express suggest malign transform gs negat tumor tsod mice contain featur similar various subtyp hca differ hca subtyp occur liver report human howev divers patient background limit abil conduct detail multifacet analysi tsod mice may share similar mechan hca develop human time review pathogenesi hca genet environment perspect expect tsod mice make contribut regard | D018248;D006528;D003920;D008113;D024821;D065626 | T191;T047 |
36,233,224 | mes sv cell sensit lipopolysaccharid peptidoglycan poli c express il cytokin mesangi cell mc maintain architectur cellular communic indirect join glomerular filtrat rate correct function glomerulus consequ cell activ constant respons chang intraglomerular environ due metabol imbal infect il member il famili cytokin initi maintain inflamm differ tissu acut chronic patholog includ skin lung intestin kidney il describ develop tubulointerstiti lesion product inflammatori environ associ metabol mesangioprolif disord particip il function dysregul consequ generat inflammatori environ mcs presenc microbi stimul yet elucid work mes sv cell cultur stimul classic pathogen associ molecular pattern pamp mimick infect negat posit bacteria well viral infect lipopolysaccharid lps peptidoglycan pgn microbi wall compon viral mimic poli c use mrna protein express il member assess observ differenti dose depend il mrna protein express lps pgn poli c stimul il found cell treat lps il il favor pgn poli c stimul suggest microbi compon particip activ mcs lead product il specif member may particip origin mainten inflamm glomerular environ associ infect | D016207;D008070 | T109;T116;T129 |
36,233,223 | potenti protect mechan equol metabolit soy isoflavon gut microbiom cognit declin dementia equol metabolit soy isoflavon daidzein transform gut microbiom biolog potent among soy isoflavon metabolit soy isoflavon phytoestrogen exert action estrogen receptor epidemiolog studi east asia soy isoflavon regular consum show dietari isoflavon intak invers associ cognit declin dementia howev random control trial soy isoflavon western countri general show cognit benefit discrep result may attribut equol product capabl consum soy isoflavon east asian produc equol wherea western recent observ clinic studi japan show equol soy isoflavon invers associ multipl vascular patholog contribut cognit impair dementia includ arteri stiff white matter lesion volum equol better permeabl blood brain barrier soy isoflavon although affin estrogen receptor similar equol also potent antioxid among known soy isoflavon although equol avail dietari supplement long term trial human examin effect equol supplement arteri stiff cerebrovascular diseas cognit declin dementia | D060825;D003704;D000069196;D007529 | T007;T121;T001;T109;T048 |
36,233,222 | select crispr edit knock cell crispr technolog afford simpl robust way edit genom cell provid power tool basic research medicin use cas target genom site effici make specif mutat site much less depend endogen dna repair machineri various strategi develop increas effici knock mutagenesi often desir cell remain small percentag total popul improv effici strategi select edit cell develop applic select foreign gene link direct gene interest goi altern co edit goi edit along select gene enrich desir cell sinc cell success edit select gene like also edit goi minim perturb host genom scarless select strategi develop modifi cell mutat sole goi review discuss strategi employ improv specif genom edit mammalian cell focus way select success edit cell | D064113;D000072669 | T063;T040 |
36,233,221 | purif biochem kinet character novel alkalin sn regioselect triacylglycerol lipas penicillium crustosum thom strain p isol moroccan oliv mill wastewat novel extracellular lipas filament fungus ascomycota strain p isol oliv mill wastewat purifi character strain identifi penicillium crustosum thom base sequenc analys penicillium crustosum thom strain p lipas pcrl purifi fold homogen use ammonium sulfat precipit chromatographi q sepharos fast flow column total yield purifi pcrl molecular mass kda estim sds page nh termin amino acid residu show high degre homolog penicillium lipas specif activ pcrl ph c found umg oliv oil trioctanoin emuls respect pcrl exhibit clear regioselect toward sn posit surfac coat triglycerid esterifi eleostear acid sn posit pcrl complet inhibit orlistat mm phenylmethylsulfonylfluorid mm diiodopropyl fluorophosph suggest belong serin lipas famili pcrl show high activ stabil presenc water immisc organ solvent surfact oxid agent show consider compat commerci laundri deterg wash perform analysi reveal could effect remov oil stain henc pcrl sever attract properti make promis potenti candid deterg formul | D008049;D031658 | T116;T002;T121;T126;T168 |
36,233,220 | effect ino hepat warm ischaemia reperfus model mice rat systemat review meta analysi warm ischaemia usual induc pringl manoeuv pm hepatectomi current wide accept standard protocol minimis ischaemia relat injuri reduc ischaemia reperfus damag activ area research systemat review meta analysi focus induc nitric oxid synthas ino earli inflammatori respons hepat ischaemia reperfus injuri hiri mous rat liver model systemat search studi perform within three databas studi meet inclus criteria subject qualit quantit synthesi result perform meta analysi studi group differ hiri model ischaemia time addit investig possibl correl endotheli nitric oxid synthas eno nitric oxid regul ino express includ studi elig meta analysi reveal ino upregul almost hiri abl show increas ino regardless ischemia reperfus time addit found direct associ eno ino sex gap primarili male experiment anim use observ lead higher risk outcom translat human sex | D008107;D015427 | T047;T037;T033 |
36,233,219 | characterist cytotox taraxacum mongolicum taraxacum formosanum human breast cancer cell breast cancer high heterogen diseas clinic divid three main subtyp estrogen receptor er progesteron receptor pr posit human epiderm growth factor receptor posit tripl negat breast cancer tnbc high metastat potenti resist endocrin therapi target therapi chemotherapi tnbc repres enorm clinic challeng genus taraxacum use treat breast cancer tradit medicin appli aqueous extract two taraxacum speci mongolicum formosanum compar potenti antitumor effect three human breast cancer cell line mda mb er pr zr er pr mcf er pr result show mongolicum exert cytotox effect mda mb cell includ induct apoptosi reduct cell prolifer disrupt mitochondri membran potenti andor downregul oxygen consumpt rate mongolicum formosanum decreas cell migrat coloni format three cell line exert suppress effect mcf cell prolifer base metabol activ brdu incorpor enhanc prolifer zr cell base brdu incorpor formosanum induc ribotox stress mda mb zr cell mongolicum summari find suggest mongolicum show greater cytotox three test breast cancer cell line especi tnbc mda mb cell line | D001943;D031205;D064726 | T191;T002 |
36,233,218 | generat flagdykddddk epitop tag knock mice use gonad enabl detect endogen camkii protein specif antibodi necessari cellular tissu express biochem function analys protein complex howev generat specif antibodi often time consum effort intens epitop tag endogen protein appropri posit overcom problem investig epitop tag posit use alphafold protein structur predict develop flagdykddddk tag knock camkii camkii mice combin crispr cas genom edit electropor gonad gonad possibl insert small fragment bp genom target gene enabl effici conveni tag small epitop experi commerci avail anti flag antibodi could readili detect endogen camkii protein western blot immunoprecipit immunohistochemistri data demonstr generat flagdykddddk tag knock mice gonad use conveni choic especi specif antibodi unavail | D018274;D000072669 | T059;T063 |
36,233,217 | associ ngf mitochondri respir autism spectrum disord ngf molecul pleiotrop role affect neuro immun function energi homeostasi synapt plastic mechan ngf induc neuron differenti well establish effect mitochondria autism spectrum disord asd still unclear hypothes ngf induc neuron develop requir larg amount energi mitochondria asd overload meet new function requir | D000067877 | T048 |
36,233,216 | genom wide identif character banana ca atpas gene express analysi differ concentr ca treatment ca atpas confirm play import role plant growth develop stress respons howev studi banana musa acuminata ca atpas limit studi identifi ca atpas gene banana includ p iia er endoplasm reticulum type ca atpas maeac p iib auto inhibit ca atpas maaca maeac maaca could classifi two three subfamili respect classif well support gene structur encod protein motif distribut banana ca atpas predict plasma membran locat promot region banana ca atpas contain mani cis act element transcript factor bind site tfbs gene express analysi show banana ca atpas differenti express differ organ investig express pattern banana root differ concentr ca treatment found banana ca atpas member high express mm mm ca treatment express decreas mm mm ca treatment suggest downregul might close relat reduc ca accumul retard growth low ca ca defici condit studi contribut understand role ca atpas banana growth ca manag | D028521 | T168;T002 |
36,233,215 | investig intestin absorpt excret paracetamol streptozotocin induc hyperglycemia phenol drug molecul metabol among other small intestin enterocyt conjug reaction glucuronid sulfat show great import transform although oxid reaction signific process depend substitu phenol compound react function group hydroxyl carboxyl patholog condit eg perman hyperglycemia diabet alter activ conjug possibl oxid enzym thus form chang metabol pattern eventu provok oxid stress rat intestin perfus model use investig way experiment hyperglycemia affect paracetamol intestin elimin metabol hyperglycemia induc administr streptozotocin two hundr fifti paracetamol use intestin perfus solut quantit paracetamol major metabolit intestin perfus isocrat high perform liquid chromatographi method uv vis detect develop result reveal quantiti measur metabolit glucuronid sulfat cystein mercaptur acid conjug increas effect streptozotocin induc hyperglycemia also small intestin homogen glutathion level show decreas hyperglycemia level paracetamol administr contrast tissu level cystein lower streptozotocin induc hyperglycemia increas administr paracetamol chang activ intestin cyp cyp e cyclooxygenas cox enzym determin control hyperglycem case still signific observ enzym activ elev intestin cox enzym decreas amount activ intestin cypa enzym cype enzym activ practic changeless result cystein level intestin homogen least part explain regul function cystein occurr oxid stress | D000082;D006943 | T121;T047;T109;T033 |
36,233,214 | generat small shuttl vector effect genet engin methanosarcina mazei allow first insight plasmid replic mechan methanoarchaeon due role methan product methanoarchaea high ecolog relev genet system ever establish last two decad system protein express methanosarcina use comprehens shuttl vector establish howev detail replic mechan methanoarchaea remain unknown report signific optimis rather larg shuttl vector pwm kbp generat metcalf decreas size mean delet sever non code region ssra gene result plasmid prs still stabli replic mazei like due reduc size show signific higher transform effici compar pwm addit investig essenti gene repa code rep type protein repa heterolog express escherichia coli purifi characteris demonstr signific bind nick activ supercoil plasmid dna base find propos optimis shuttl vector replic via roll circl mechan repa initi replic protein methanosarcina basi bioinformat comparison propos presenc locat doubl strand singl strand origin need verifi | D005822;D017020 | T194;T114 |
36,233,213 | select anti leishmani strathclyd minor groov binder use n oxid tail group modif neglect tropic diseas leishmaniasi caus leishmania spp becom problemat due emerg drug resist strain therefor new drug treat leishmaniasi novel mechan action urgent requir strathclyd minor groov binder mgbs emerg class anti infect agent shown potent activ various bacteria virus fungi parasit herein shown mgbs potent activ l donovani n oxid deriv tertiari amin tail typic mgbs lead select anti leishmani activ addit use mgb n oxid deriv shown retain strong bind dna dimer find support studi anti leishmani mgbs novel therapeut | D007891;D010087 | T197;T204 |
36,233,212 | screen epigenet therapeut target non small cell lung cancer reveal padi kdmb promis candid despit advanc diagnost therapeut approach lung cancer new therapi target metastasi specif regul cancer gene need studi screen small librari epigenet inhibitor non small cell lung cancer nsclc cell line evalu epigenet target potenti role metastat nsclc potenti candid rank streamlin approach use silico vitro experi base public avail databas evalu real time qpcr target gene express cell viabil invas assay transcriptom analysi surviv rate patient lung adenocarcinoma invers correl gene express eight epigenet target systemat review literatur confirm four alreadi identifi target treatment nsclc use nontox dose remain inhibitor kdmb padi identifi potenti target affect invas migrat metastat lung cancer cell line transcriptom analysi kdmb padi treat cell show alter express import gene relat metastat process conclus show kdmb padi promis target inhibit metastasi lung adenocarcinoma cancer cell | D000077192;D002289;D056484;D008175;D000080002 | T191;T126;T116 |
36,233,211 | p selectin critic factor platelet mediat protect restraint stress induc gastrointestin injuri mice psycholog stress associ increas risk gastrointestin gi tract diseas evid indic platelet facilit gi tissu repair intestin anastomosi model howev whether platelet involv nativ mechan rescu stress induc gi injuri maintain gi homeostasi remain elus p selectin defici selp mice display higher stress induc gi injuri compar wild type selp mice p selectin specif express platelet hypothes p selectin express platelet play protect role rescu stress induc gi injuri goal clarifi putat protect role platelet gi system therebi develop feasibl intervent strategi platelet transfer overcom stress induc gi injuri monitor plasma level gi nonabsorb evan blue dye reveal progress cours gi injuri live mice found intraven treatment purifi platelet amelior stress induc gi leakag transfer platelet wild type mice potent selp mice rescu stress induc gi leakag recipi platelet transfer mediat rescu conduct p selectin depend manner addit platelet mediat protect associ correct stress induc aberr gi mrna express includ tight junction claudin occludin well stress induc gene activ transcript factor amp activ protein kinas transfer wild type platelet wild type selp mice furthermor stress induc apoptosi cd gi epitheli cell rescu transfer wild type p selectin defici platelet result suggest platelet play protect role maintain gi homeostasi stress vivo p selectin molecular target manag stress induc gi tract injuri | D055372;D051700 | T126;T116 |
36,233,210 | non code rna relat mapk signal pathway liver cancer advanc high throughput sequenc analysi evalu chromatin state map reveal eukaryot cell produc mani non code transcriptsrna strong associ observ non code rnas cancer develop mitogen activ protein kinas mapk belong serin threonin kinas famili primari signal pathway involv cell prolifer cell surfac nucleus play import role various human diseas non code rnas associ mapk signal pathway play signific role develop sever malign includ liver cancer review summar molecular mechan interact microrna lncrna non code rnas develop liver cancer associ mapk signal pathway briefli discuss therapeut strategi liver cancer relat ncrna mapk signal pathway | D008113;D035683;D062085 | T191;T123;T114 |
36,233,209 | aquacobalamin acceler orang ii destruct peroxymonosulf via transient format secocorrinoid mechanist studi besid use medicin vitamin b cobalamin deriv found numer applic catalyst howev studi relat activ oxid via cobalamin scant work show addit aquacobalamin h ocbl acceler destruct azo dye orang ii peroxymonosulf hso aqueous solut neutral weak alkalin media process initi modif corrin macrocycl hso requir preliminari deproton aqua ligand h ocbl give hydroxocobalamin produc dioxo secocobalamin isom dioxo secocobalamin acid solut concentr hydroxocobalamin neglig format dioxo seco speci observ reaction h ocbl hso result slow chromophor bleach use terephthal acid demonstr format hydroxyl radic mixtur h ocbl hso wherea generat sulfat radic prove compar effect ethanol nitrobenzen orang ii destruct use h ocblhso system reaction mechan includ bind hso co iii ion dioxo secocobalamin result deproton labil bond lead format sulfat hydroxyl radic react orang ii | D006879;D014805 | T121;T109;T127;T114 |
36,233,208 | mendelian random studi lifestyl relat risk factor osteoarthr prisma review meta analysi risk factor osteoarthr oa often exert effect protract time cours mendelian random mr studi therefor advantag convent observ studi studi causal effect long term lifestyl relat risk factor oa howev given heterogen design exist mr studi oa report causal estim effect remain inconsist thus obscur true extent biolog effect oa lifestyl risk factor conduct prisma systemat review specif includ mr studi investig causal effect lifestyl relat risk factor oa causal estim various lifestyl factor pool meta analysi qualiti studi assess accord strobe mr guidelin total studi evalu includ overal studi includ high qualiti low risk bias meta analysi demonstr posit causal effect bmi ivw random effect negat causal effect serum calcium ivw random effect ldl level ivw random effect oa despit heterogen design estim causal effect provid various mr studi meta analysi suggest lifestyl relat risk factor form bmi serum calcium ldl true biolog effect develop oa | D057182;D010003 | T047;T062 |
36,233,207 | current develop futur applic prospect plant deriv polyphenol bioactiv substanc curcumin novel feed addit livestock poultri curcumin cur kind natur orang yellow phenol compound main extract stem root turmer plant speci genus curcuma furthermor also import activ ingredi exert pharmacolog function turmer recent year cur frequent report attract widespread attent scholar world due numer biolog function good applic prospect anti inflammatori anticanc antioxid provid lipid lower effect etc addit ad certain dose cur livestock poultri feed import anim growth develop play key role anim metabol reproduct immun clinic health care review aim summar base publish paper observ physic chemic properti biolog function plant deriv bioactiv ingredi cur especi regard latest research progress regul intestin health well current develop futur applic prospect livestock poultri novel feed addit provid theoret practic refer studi applic cur novel feed addit potenti new antibiot substitut therebi improv research field plant deriv bioactiv ingredi promot healthi develop livestock poultri | D000970;D003474 | T121;T109;T130 |
36,233,206 | hair growth promot effect fish collagen peptid human dermal papilla cell cbl mice modul wnt catenin bmp signal pathway fish deriv collagen recent emerg altern collagen sourc bioactiv properti includ enhanc hair skin health also cost effect high bioavail addit fewer side effect compar collagen porcin skin bovin skin collagen peptid cps extract scale mozambiqu tilapia oreochromi mossambicus report promot hair skin health studi sought evalu effect cps hair growth use vitro vivo model cp signific enhanc hair regrowth prolifer human dermal papilla cell hdpcs vitro cp oral administ cbl mice week confirm hair growth promot effect mice divid four group negat control distil water posit control mgkg finasterid cp mgkg cp cp mgkg cp cp treatment signific enhanc prolifer hdpcs compar finasterid addit enhanc hair regrowth particular cp treatment achiev hair growth index similar pc h e stain cp group exhibit high ratio furthermor cp increas express hair growth factor igf vegf krt gprcd ki decreas growth inhibitori factor tgf furthermor cp signific upregul wnt catenin pathway downregul bmp pathway therefor result indic cp could use food supplement nutraceut hair loss prevent well hair regrowth alopecia | D019485;D003094;D006197;D051176 | T023;T116;T122;T121;T123 |
36,233,205 | omega polyunsatur fatti acid protect high fat diet induc morpholog function impair brown fat transgen fat mice role omega polyunsatur fatti acid n pufa regul energi homeostasi remain poor understood studi use transgen fat mous model produc n pufa endogen investig n pufa regul morpholog function brown adipos tissu bat found high fat diet hfd induc remark morpholog chang bat character whiten due larg lipid droplet accumul within bat cell associ obes wild type wt mice wherea chang bodi fat mass bat morpholog signific allevi fat mice express thermogen marker lypolyt enzym signific higher fat mice wt mice fed hfd addit fat mice signific lower level inflammatori marker bat lipopolysaccharid lps plasma compar wt mice furthermor fat mice resist lps induc suppress ucp pgc express lipid deposit bat data demonstr high fat diet induc obes associ impair bat morpholog whiten function amelior elev tissu status n pufa possibl suppress effect lps inflamm thermogenesi | D002001;D015525 | T121;T024;T123;T109 |
36,233,204 | assess ddah ddah contribut psychiatr disord via silico method contribut nitric oxid synthas noss pathophysiolog sever neuropsychiatr disord recogn role regul dimethylarginin dimethylaminohydrolas ddah less understood studi object estim ddah ddah associ biolog process implic major psychiatr disord use public access express databas sinc co express gene like involv biolog process investig co express pattern ddah ddah dorsolater prefront cortex psychiatr patient control subject signific differ ddah ddah express level schizophrenia bipolar disord patient compar control meanwhil data suggest patient ddah ddha undergo function shift mirror chang co express gene pattern disarrang appear loss express level correl ddah ddah gene associ psychiatr disord reduc function similar ddah ddah co express gene patient group find evid possibl involv ddah ddah neuropsychiatr disord develop under mechan need experiment valid | D000581;D001688;D001523 | T116;T121;T126;T123;T048 |
36,233,203 | triphenylphosphonium modifi mesopor silica nanoparticl enhanc algicid efficaci cyclohexyl dichlorobenzyl amin mesopor silica nanoparticl msnps wide use deliveri differ hydrophil hydrophob drug owe larg surfac area eas chemic alter hand triphenylphosphonium cation tpp high lipophil great mitochondri home properti stimul intern drug cell therefor design tpp modifi msnp enhanc algicid activ new algicid agent cyclohexyl dichlorobenzyl amin dp studi algicid activ evalu assess growth rate inhibit two harm algal bloom hab heterosigma akashiwo heterocapsa circularisquama treatment dp load msnp tpp msnp dp dmso control h akashiwo ic valu tpp msnp msnp respect wherea valu control h circularisquama ic valu tpp msnp msnp respect wherea valu control result indic tpp msnp effici enhanc algicid activ dp signifi prospect use dp load tpp msnp algicid agent superior manag hab | D004141;D053758 | T073;T204 |
36,233,202 | antitumor effect timosaponin c myc inhibit colorect cancer cell combin treatment effect fu doxorubicin timosaponin ta extract rhizom anemarrhena asphodeloid bung report affect various diseas cancer alzheim diseas allergi howev under molecular mechan impact larg unknown present studi hypothes ta induc apoptosi inhibit c myc express via cnot midip hct mtt assay coloni format assay use measur cell viabil prolifer protein express apoptot marker oncogen measur use immunoblot immunofluoresc assay interact midip c myc confirm perform immunoprecipit assay ta mark inhibit colon cancer cell prolifer consist ta regul apoptot protein pro parp caspas ta inhibit half life c myc suppress express respons serum stimul addit ta enhanc apoptot effect doxorubicin fu colon cancer cell altogeth result reveal mechan ta induc apoptosi inhibit c myc express via cnot midip hct may help develop new therapi colon cancer base ta futur | D003110;D015179 | T191 |
36,233,201 | endocrin disrupt chemic effect children know need learn thousand natur manufactur chemic defin endocrin disrupt chemic edc interfer hormon activ endocrin system summar discuss know still need learn edc pathogen mechan action well effect common edc endocrin system health childhood medlin databas pubm search may filter edc endocrin diseas children edc group compound high heterogen usual disrupt endocrin system mimick interf natur hormon interf bodi hormon balanc mechan individu edc studi detail human cocktail effect still unclear utero earli postnat life andor pubert develop high suscept period exposur human epidemiolog studi suggest edc affect prenat growth thyroid function glucos metabol obes puberti fertil sever mechan studi need clarifi edc main act epigenet process better understand edc effect human health crucial develop futur regulatori strategi prevent exposur ensur health children today futur generat environ | D052244 | T131;T039 |
36,233,200 | prenat treatment induc chang brain monoamin express gene relat monoamin metabol mous model social hierarchi depress probabl via epigenet mechan reduct level monoamin serotonin dopamin brain report patient anim depress univers methyl donor epigenet modul success use adjunct treatment depress previous found prenat treatment submiss sub mice serv model depress allevi mani behavior depress symptom present studi treat pregnant sub mice mgkg day gestat studi level monoamin express gene relat monoamin metabol prefront cortex pfc age month data compar normal salin treat sub mice exhibit depress like symptom increas level serotonin pfc femal sub mice male level hiaa chang increas level dopamin dopac male femal increas level hva femal level norepinephrin metabolit mhpg unchang treatment chang express sever gene involv metabol monoamin also sex relat manner increas sever monoamin induc pfc may explain allevi depress like symptom moreov chang gene express month treatment probabl reflect benefici effect epigenet modul treatment depress | D004298;D012701 | T121;T109;T123 |
36,233,199 | hippo yki signal pathway posit regul immun respons vibrio infect shrimp hippo pathway activ hippo wart wts kinas result phosphoryl yorki yki prevent nuclear transloc shrimp aquacultur threaten vibrio genus bacteria studi examin role hippo pathway immun defens vibrio parahaemolyticus pacif white shrimp penaeus vannamei show v parahaemolyticus infect promot express yki facilit dephosphoryl nuclear transloc yki indic inhibit hippo signal upon bacteri infect complex regulatori relationship hippo pathway compon hippo wts yki immun relat transcript factor dorsal relish stat silenc hippo wts weaken hemocyt phagocytosi silenc yki enhanc suggest posit regul shrimp cellular immun hippo signal activ vivo silenc hippo wts decreas surviv rate v parahaemolyticus infect shrimp elev bacteri content tissu silenc yki show opposit result suggest activ hippo signal inhibit yki enhanc antibacteri immun shrimp | D033561;D014735;D014736 | T007;T047;T204 |
36,233,198 | mutant ataxin express age anim aggrav neuropatholog featur associ spinocerebellar ataxia type spinocerebellar ataxia type sca rare autosom domin inherit diseas affect individu diseas onset around third life decad molecular mechan under sca yet complet understood hypothes age play role sca molecular pathogenesi studi perform striatal inject mutant ataxin mediat lentivir vector young age anim twelv week post inject analyz striatum sca neuropatholog featur specif age hallmark result show age anim higher number mutant ataxin aggreg neuron marker loss compar young anim apoptosi marker cleav caspas cresyl violet stain also indic increas neuron death age anim group addit mrna level microtubul associ protein light chain b lc sequestosom sqstmp alter age anim group suggest autophag pathway dysfunct work provid evid age anim inject expand ataxin aggrav sca diseas phenotyp suggest age play import role sca diseas onset diseas progress | D000067698;D020754 | T047;T123;T116 |
36,233,197 | atr ftir biosensor antibodi detect analysi qualiti control drug product paramount import pharmaceut world ensur product safeti effici consist case complex biomolecul therapeut protein small variat bioprocess paramet induc substanti variat term structur impact drug product qualiti condit obtain high reproduc graft mercaptoundecano acid determin basi develop easi use cost effect timesav biosensor base atr ftir spectroscopi abl detect immunoglobulin product germanium crystal use intern reflect element ire ftir spectroscopi coval coat immunoglobulin bind protein therebi function surfac could bind immunoglobulin present complex media cultur media biopharmaceut product potenti subsequ analysi structur atr ftir spectroscopi make biosensor power tool monitor product biotherapeut assess import critic qualiti attribut cqas high order structur aggreg level | D001688;D015374;D005857 | T059;T121;T075;T123;T196 |
36,233,196 | nod signal circuitri allergen sensit worsen experiment neutrophil asthma promot thth profil asthma patient healthi subject nucleotid bind oligomer domain nod recogn pathogen associ develop asthma moreov nod adjuv use vaccin design boost immun respons muramyl di peptid mdp nod ligand abl promot thth respons furthermor polymorph nod receptor associ allergi asthma develop studi aim evalu mdp given adjuv allergen sensit may worsen develop thth respons use mous model thth type allerg neutrophil airway inflamm aai dog allergen vitro polar human naiv cell dendrit cell dc healthi dog allerg asthma subject mous model intranas co administr mdp modifi aai paramet includ thth type lung inflamm human mdp co stimul allergen prime dc chang polar profil cell healthi subject elicit thth profil asthma subject compar mdp alon result support idea nod may involv infect relat develop asthma care taken asthma patient nod adjuv might use non sensit individu | D000485;D001249;D053473 | T047;T123;T116;T129 |
36,233,195 | candid modifi gene penetr leber hereditari optic neuropathi leber hereditari optic neuropathi lhon matern transmit diseas caus mitochondria dna mtdna mutat character acut subacut visual loss predomin affect young men mtdna mutat transmit matern lineag howev approxim men women harbor pathogen mtdna mutat develop optic neuropathi reflect incomplet penetr unexplain male preval patient male nuclear modifi gene presum affect penetr lhon convent genet method prior studi fail solv under pathogenesi whole exom sequenc wes new molecular techniqu sequenc protein code region gene whole genom perform wes five famili member sampl divid proband group proband acut onset lhon n control group carrier includ mother relat carrier mtdnsa mutat without clinic manifest lhon n whole exom analysi found mani mitochondria relat mt relat nuclear gene high percentag variant either proband group control group mt gene differ mutat percentag proband control group includ ak nsun rdh coq fahd addit pathway analysi reveal gene associ cofactor metabol pathway famili base analysi show sever candid mt gene includ metapd cg gt acacb cdel cg gt c nipsnapb cg gt c cc gt g nsun ca gt g involv penetr lhon gwas genom wide associ studi perform found adgrg chra g pole chrt g ermap chra g pigr chrc g cdcbpb chra g prok chra g bcan chr c nes chra gt c c may involv incomplet penetr male preval still major unexplain issu lhon whole exom analysi found sever mt gene high percentag variant involv famili base analysi pathway analysi suggest differ mutat burden mt gene underlin biosynthesi metabol pathway addit gwas analysi also reveal sever candid nuclear modifi gene new technolog wes contribut provid high effici candid gene screen function molecular genet | D005768;D029242;D042662 | T047;T123;T116;T125 |
36,233,194 | identif candid gene breast cancer induc estrogen plus progestogen use bioinformat analysi menopaus hormon therapi mht wide use treat menopaus relat symptom menopaus women howev mht therapi controversi increas risk breast cancer differ estrogen progestogen combin molecular basi behind phenomenon current understood address issu identifi differenti express gene deg estrogen plus progestogen treatment ept estrogen treatment et use gene express omnibus geo cancer genom atlas tcga data result total upregul deg first identifi seven deg relat cell cycl ccne cdca rad tcf kntc mcm neil valid rt qpcr specif seven deg increas ept compar et p lt higher express level breast cancer adjac normal tissu p lt next found estrogen receptor er posit breast cancer patient higher cnne express shorter overal surviv time p lt effect observ six deg p gt interest molecular dock result show ccne might bind estradiol kcalmol progesteron kcalmol medroxyprogesteron acet kcalmol relat strong bind affin respect import cnne protein level could upregul ept attenu estrogen receptor antagonist acolbifen interact cancer driver gene akt kras high mutat frequenc gene tp pten breast cancer patient conclus current studi show ccne cdca rad tcf kntc mcm neil might contribut ept relat tumorigenesi breast cancer ccne might sensit risk indic breast cancer risk women use mht | D001943;D011372 | T191;T039;T125;T121 |
36,233,193 | safe effici sigma ligand potenti drug candid multipl sclerosi multipl sclerosi ms autoimmun demyelin neurodegen diseas central nervous system cns current manag strategi suppress modul immun function consequ known side effect demonstr high level success limit new relaps howev neurodegen process still affect grey white matter central nervous system sigma sr ligand regul chaperon implic mani biolog process various cns target diseas act neural plastic myelin neuroinflamm among protein involv ms sr therefor emerg promis new target standard robust method adopt analyz adsorpt distribut metabol excret adm properti safeti pharmacolog toxicolog previous synthet simpl benzamid deriv compound nanomolar affin sr high select cytotox good metabol stabil compound also character agonist base well valid assay prior vivo investig interest found oral administr compound result overal signific reduct clinic progress ms experiment model effect mediat sr action result suggest potenti use compound treatment ms | D002493;D009103;D019636;D017480 | T047;T116;T192 |
36,233,192 | crosstalk cxcrackr egfr signal breast cancer cell better understand complex crosstalk among key receptor signal pathway involv cancer progress need improv current therapi investig cell model repres major subtyp breast cancer bc interplay chemokin cxclcxcrackr egf receptor egfr famili signal cascad cell line display high heterogen express profil cxcrackr chemokin receptor predomin intracellular local differ proport cell surfac cxcr ackr doubl posit cell subpopul display overal modest activ oncogen pathway respons exogen cxcl alon interest find mda mb lumin b subtyp overexpress mcf lumin mda mb tripl negat cell cxcrackr egfr receptor famili share signal compon crosstalk mechan concurr promot erk activ key involv g protein coupl receptor kinas grk signal hub cytosol tyrosin kinas src find suggest certain bc subtyp relev cooper cxcrackr growth factor receptor take place integr concurr signal eman tumor microenviron foster cancer progress | D001943;D054387;D019718 | T191;T129;T116;T192 |
36,233,191 | polyphyllin ii induc protect autophagi apoptosi via inhibit pikaktmtor stat signal colorect cancer cell polyphyllin ii ppii natur steroid saponin occur rhizoma paridi demonstr exhibit anti cancer activ varieti cancer cell howev anti colorect cancer crc effect mechan action ppii rare report present studi show ppii inhibit prolifer hct sw cell moreov ppii induc gm phase cell cycl arrest apoptosi well protect autophagi crc cell found ppii induc autophagi associ inhibit pikaktmtor signal western blot result reveal ppii lower protein level phospho src tyr phospho jak tyr phospho stat tyr stat target molecul crc cell overactiv stat attenu cytotox ppii hct cell indic involv stat inhibit anti crc effect ppii ppii mgkg mgkg ip everi day suppress hct tumor growth nude mice align vitro result ppii inhibit prolifer induc apoptosi lower protein level phospho stat phospho akt phospho mtor xenograft data suggest ppii could potent therapeut agent treatment crc | D015179;D012503 | T191;T109 |
36,233,190 | lifestag sex specif genet effect metabol disord adult popul korea korean genom epidemiolog studi although mani genom wide associ studi gwass evalu associ metabol disord current studi first attempt analyz genet risk factor various metabol disord accord sex age group life cours korean adult total popul peopl includ gwas genet trait eight metabol phenotyp investig peri postmenopaus women compar younger group men correspond age group metabol phenotyp includ general obes abdomin obes hypertens type diabet hypercholesterolemia hypertriglyceridemia hypo high densiti lipoprotein cholesterolemia metabol syndrom total particip gwas result eight metabol phenotyp found signific loci loci first report associ risk metabol disord interest signific loci present associ various phenotyp present correl phenotyp addit analyz divid gender age young adult peri menopaus group older adult specif identifi specif loci peri menopaus women meanwhil sever genet factor associ metabol disord newli report studi particular sever gene signific associ one metabol phenotyp singl specif group find suggest menopaus transit rather age potenti influenc genet risk metabol disord addit genet loci low frequenc may play role metabol disturb specif sex age group genet trait deriv studi may contribut understand genet risk factor metabol disord korean popul | D003924;D024821 | T047 |
36,233,189 | deciph mechan action sortilinneurotensin receptor prolifer regul colorect cancer purpos review deciph mechan pathway lead complex role neurotensin nts receptor also call sortilin solubl counterpart ssortilinntsr larg amount physiolog patholog function particular cancer progress metastasi sortilinntsr belong famili type transmembran protein shed releas extracellular domain cell express protein sinc discoveri extens investig role form sortilinntsr membran bound solubl form demonstr involv mani pathophysiolog process cancer develop cardiovascular diseas alzheim diseas diabet major depress review focus particular implic membran bound solubl sortilinntsr colorect cancer tissu cell depend abil associ either neurotrophin nts nts receptor well cellular compon integrin end review hypothes suggest counteract deleteri effect protein order develop effect anti cancer treatment | D033942;D015179;D018028 | T191;T123;T116;T192 |
36,233,188 | plasmon conduct structur tco film embed cu nanoparticl cu nanoparticl produc use solid state dewet dri nm cu layer laser ablat cu solid target wet aceton methanol morpholog chemic composit nanoparticl investig function synthesi method key paramet anneal temperatur c liquid environ ablat cu nanoparticl embed transpar conduct oxid tco film aluminum dope zinc oxid azo zirconium dope indium oxid izro tco bott cu nanoparticletco top structur synthes combin azo izro top bottom layer goal achiev plasmon conduct structur photovolta applic via comparison involv method fabric structur particular solid state dewet produc facet spheric depend anneal temperatur nanoparticl averag size nm laser ablat produc spheric nanoparticl nm dri wet plasmon conduct structur function tcos employ temperatur anneal could reach sheet resist sq energi band gap e gap absorb transmitt reflect plasmon conduct structur investig uv vis nir rang show depend sequenc top bottom tco best transmitt dri plasmon conduct structur wet plasmon conduct structur latter show higher diffus transmitt visibl rang | D053758;D015034 | T121;T073;T197 |
36,233,187 | improv hplc quantif mercaptopurin metabolit red blood cell monitor data literatur analysi thiopurin drug azathioprin aza mercaptopurin mp use extens pediatr adult patient inflammatori neoplast diseas metabol thioguanin nucleotid tgn methyl mercaptopurin nucleotid mmpn balanc tgn mmpn high variabl monitor recommend benefit outcom give rise conflict result potenti increas differ quantifi mp metabol aim report hplc uv procedur use laboratori quantifi red blood cell rbcs tgn mmpn deriv mmp patient treat thiopurin addit test sometim confirmatori improv method standard comparison two method count rbcs show metabolit concentr slight lower wash resuspend rbcs whole blood perchlor acid dithiothreitol dtt final sampl concentr min hydrolysi select acid hydrolysi monitor data patient receiv aza mp show steadi state tgn mmpn recommend therapeut rang method discuss light technic condit sampl stabil data public identifi sinc first analyt report monitor data demonstr requir inter patient variabl tgn mmpn concentr high sampl treat patient | D015212;D015122 | T121;T047;T114 |
36,233,186 | promot melanoma cell prolifer cyclic strain regulatori morphogenesi genotyp phenotyp acral melanoma obvious differ uv radiat induc melanoma base clinic data mechan stimul believ potenti caus acral melanoma case desir clarifi role mechan stimul progress acral melanoma howev patholog process cyclic strain stimul acral melanoma still unclear studi influenc cyclic strain melanoma cell prolifer analyz use specif design cell cultur system result cyclic strain could promot melanoma cell prolifer ineffici disrupt cytoskeleton organ therefor mechanotransduct mechan promot prolifer explor myosin actin polymer demonstr relat cyclic strain influenc morphogenesi melanoma cell addit activ mechanosens transcript factor yap relat regulatori morphogenesi furthermor express level melanoma involv gene regul cyclic strain final acceler dna synthesi result studi provid supplementari inform understand acral melanoma | D008545;D012878 | T191 |
36,233,185 | lpcat knockdown alter barrier integr cellular bioenerget human urothelium urothelium transit stratifi epithelium line lower urinari tract provid tight barrier urin whilst retain capac stretch rapid resolv damag role glycerophospholipid urotheli barrier function larg unknown despit import membran structur integr protein complex assembl master regulatori role ppar urotheli differenti perform lipidom transcriptom characteris urotheli differenti reveal metabol switch signatur fatti acid synthesi lipid remodel includ fold upregul lpcat lpcat knockdown urotheli cultur exhibit impair prolifer rate develop elev tran epitheli electr resist upon differenti associ reduc delay capac restitut barrier function wound specif reduct pc fatti acyl chain upon knockdown consist lpcat specif unlik elicit broad barrier function chang howev transcriptom analysi lpcat knockdown support lpc induc reduct dag avail predict limit pkc activ tspo abund predict limit endogen atp phenotyp confirm pkc tspo inhibit togeth data suggest integr role lipid mediat urotheli barrier function highlight strength combin lipidom transcriptom analys characteris tissu homeostasi | D008243;D047495;D019459 | T024;T126;T116;T192 |
36,233,184 | holm oak quercus ilex subsp ballota desf samp bark aqueous ammonia extract control invas forest pathogen holm oak quercus ilex subsp ballota desf samp bark common use remedi treat gastrointestin disord throat skin infect hemorrhag dysenteri also previous report methanol extract possess antibacteri activ relat rich quercus spp extract phenol compound flavonoid tannin howev inform antifung includ oomycet properti bark q ilex subspeci ilex ballota work report character aqueous ammonia extract bark ftir gc ms result vitro ex situ inhibit test three phytopathogen main phytochem compon identifi inositol tran squalen butoxi butanol gulopyranos lyxos dimethyl benzo h quinolin catechol methoxyphenol efficaci extract control forest phytopathogen test vitro fusarium circinatum respons pitch canker pinus spp cryphonectria parasitica caus chestnut blight phytophthora cinnamomi caus root crown rot varieti host includ castanea conif eucalyptus fagus juglan quercus etc obtain ec valu gml respect much lower attain commerci strobilurin fungicid azoxystrobin extract test ex situ p cinnamomi artifici inocul excis stem garnem almond rootstock attain complet protect dose gml result suggest holm oak bark extract may promis sourc bioactiv compound invas forest pathogen includ oomycet caus declin call seca spain | D031329;D005659;D010838;D029963;D011804 | T109;T131;T002;T204 |
36,233,183 | updat current microbiolog techniqu pathogen identif infecti endophthalm infecti endophthalm vision threaten medic emerg requir prompt clinic diagnosi initi treatment howev achiev precis endophthalm manag remain challeng review provid updat overview recent studi repres current trend clinic microbiolog techniqu infecti endophthalm | D009877 | T047 |
36,233,182 | evalu dri blood cerebrospin fluid filter paper spot store transport clinic materi molecular diagnosi invas meningococc diseas improv storag transport clinic specimen diagnosi neisseria meningitidi nm infect resourc limit set evalu perform dri blood spot dbs dri cerebrospin fluid spot dcs assay dbs dcs prepar filter paper liquid specimen previous test nm unit kingdom nm detect genogroup real time pcr perform crude genom dna extract dbs n dcs n specimen target whole genom sequenc perform subset specimen dbs n dcs n overal agreement analysi liquid dri specimen ci blood ci cerebrospin fluid relat liquid specimen refer dbs dcs assay sensit ci ci respect assay specif genogroup identifi dri specimen analysi confirm meningococc infect near full length nm genom sequenc gt obtain ten specimen test allow determin sequenc type clonal complex presenc antimicrobi resist meningococc genotyp dri blood csf filter spot assay offer practic altern liquid specimen molecular genom characteris invas meningococc diseas low resourc set | D000890;D008589;D009345 | T121;T007;T047 |
36,233,181 | data integr possibl molecular clinic data fusion exampl thyroid cancer diagnost background data independ gene express sourc may integr purpos molecular diagnost cancer far multipl approach describ investig impact differ data fusion strategi classif accuraci featur select stabil allow cost diagnost test reduc method use molecular featur gene express combin featur extract independ clinic data describ patient sampl consid depend select featur two data fusion strategi earli fusion late fusion compar classif model base molecular featur compar best accuraci classif model term number featur connect potenti cost reduct diagnost classifi result show thyroid cancer extract clinic featur correl redund molecular data usag data fusion allow model obtain similar even higher classif qualiti statist signific accuraci improv p valu reduct molecular dimension featur space depend featur select method conclus strategi give compar qualiti result earli fusion method provid better featur select stabil | D013964 | T191 |
36,233,180 | mitochondri endoplasm reticulum alter case amyotroph later sclerosi caus tdp mutat amyotroph later sclerosi common form motor neuron diseas mutat tardbp gene encod rna bind protein tdp respons famili al report clinic biolog featur al patient pat mutat tpd protein diseas began right hand muscl weak equal involv upper lower motor neuron classic phenotyp without cognit impair famili histori neurolog diseas report evid famili frontotempor dementia cultur fibroblast patient character profound alter cell proteom impact particular mitochondri metabol pathway endoplasm reticulum tdp level similar control healthi fibroblast higher fraction local mitochondria mitochondri network appear fragment organell smaller spheric agreement impair proteom morpholog mitochondria basal cell respir reduc mitochondri dna level appear normal howev higher amount mitochondri dna present cytosol suggest pronounc mitochondri dna misplac promot pro inflammatori respons mediat cgasst thus case report expand clinic patholog phenotyp mutat | D000690 | T047 |
36,233,179 | effect dietari koumin growth perform intestin morpholog microbiota intestin transcript respons cyprinus carpio gelsemium elegan amp nbsp benth geb tradit medicin plant china act growth promot pig goat koumin km abund alkaloid geb produc analges anti cancer immunomodulatori effect km use aquat immun stimul growth promot effect transcript mechan investig diet contain km mgkg fed cyprinus carpio day investig effect growth perform intestin morpholog microflora biochem indic transcript mechan cyprinus carpio fed km growth promot number intestin crypt intestin microbi popul influenc km concentr km increas abund coloni afipia phyllobacterium mesorhizobium labri associ compound decomposit prolifer decreas abund coloni pathogen bacteria methylobacterium methylorubrum total differenti express gene deg among four experiment group enrich transform growth factor small mother decapentapleg tgf smad mitogen activ protein kinas mapk janus kinas signal transduc activ transcript jakstat signal pathway particular tgfbr acvrl rreb statb smad cbp c fos regul posit correl km dose km growth promot effect relat cell prolifer driven tgf smad mapk jakstat signal pathway km mgkg optim growth perform c carpio higher concentr km mgkg may induc apoptosi without signific damag fish intestin structur therefor km low concentr great potenti develop aquat growth promot addit | D002347;D064307 | T001;T032;T013;T028 |
36,233,178 | structur direct interplay tetrel halogen bond co crystal lead ii diethyldithiocarbam tetraiodoethylen co crystal lead ii complex pb cnet tetraiodoethylen c gave co crystal pb cnet c whose x ray structur exhibit small chang crystal paramet parent pb cnet supramolecular organ co crystal larg determin interplay pbs tetrel bond teb halogen bond hab compar contribut non coval contact teb observ parent complex pb cnet remain unchang co crystal analysi theoret calcul data perform crystal cluster model pb cnet c reveal non coval natur pbs teb kcalmol hab kcalmol interact indic co crystal non coval forc similar energi | D004050;D006219 | T121;T109;T196 |
36,233,177 | target epigenet regul cardiomyocyt develop therapeut cardiac regener heart failur cardiovascular diseas lead caus death global cure current therefor dire need understand mechan aris heart failur notori adult mammalian heart limit abil regener function cardiac cell cardiomyocyt injuri howev neonat mammalian heart window regener allow repair renew cardiomyocyt injuri specif timelin interest field cardiovascular regen biolog potenti target adult cardiomyocyt repair recent mani neonat cardiomyocyt regener mechan associ epigenet regul within heart review summar current promis epigenet mechan neonat cardiomyocyt regener specif emphasi potenti target mechan adult cardiac model repair injuri | D006333;D032383 | T047;T046;T025 |
36,233,176 | foxo transcript factor applic novel immun cell regul therapeut target oxid stress relat diseas forkhead box transcript factor foxo play import role maintain normal cell physiolog regul surviv apoptosi autophagi oxid stress develop matur b lymphocyt secret inflammatori cytokin cell type whose function regul foxo includ keratinocyt mucos dermi neutrophil macrophag dendrit cell tumor infiltr activ regulatori treg cell b cell natur killer nk cell foxo play crucial role physiolog patholog immun respons foxo control develop function foxp treg treg cell th cell subset cd cell play essenti role immun homeostasi infect dysregul thtreg cell balanc implic develop progress sever disord autoimmun diseas inflammatori diseas cancer addit foxo stimul mitogen activ protein map kinas pathway inhibit pi kinaseakt pathway downstream target gene foxo includ pro inflammatori signal molecul toll like receptor tlr tlr interleukin il tumor necrosi factor tnf chemokin receptor ccr cxcr b cell regul april blys regulatori modul foxp ctla dna repair enzym gadd review recent progress understand foxo key molecul involv immun cell differenti role initi autoimmun diseas caus dysregul immun cell balanc addit various diseas foxo act cancer repressor reviv activ foxo forc treg egress various tissu howev foxo regul cytotox cd nk cell tumor cell aid restor redox inflammatori homeostasi repair damag tissu activ immun cell better understand foxo regul may help develop novel potenti therapeut treat immuneoxid stress relat diseas | D001327;D009369 | T191;T047 |
36,233,175 | dp point mutat induc protein aggreg loss nuclear lamina integr impair braf ibraf function neuron cell dystrophin dp abund product duchenn muscular dystrophi gene nervous system mutat impair function associ neurodevelopment symptom present third dmd patient dp requir cluster neurotransmitt receptor neuron differenti cultur cell nonetheless precis role neuron cell remain poor understood studi analyz effect two pathogen dmd gene point mutat dp function neuron engin cy edel mutat express gfp tag dp protein variant ne sh syy neuron cell unexpect ectop express dp mutant result protein aggreg may mechanist caus effect mutat dp structur predict protein model molecular dynam simul interest dp mutant variant acquir domin negat function turn dramat impair distribut differ dp protein partner includ dystroglycan nuclear lamin ac b high mobil group hmg contain protein braf braf famili member inhibitor braf ibraf analysi dp mutant provid evid show role dp modul heterochromatin marker hkme organ neuron gene express via interact ibraf braf | D016189;D009447 | T191;T123;T116 |
36,233,174 | dynam evalu natur killer cell subpopul covid patient aim studi evalu dynam chang total natur killer nk cell differ nk subpopul accord differenti express cdcd covid patient blood sampl edta analyz day admiss moment day day nk subtyp least singlet collect sampl white blood cell gate cdssc cdcd dot plot fresh human blood lymphocyt singlet nk cell subpopul analyz base differenti express surfac marker classifi follow cd cd cd cd cd cd cd cd examin cd versus cd flow cytometri dot plot found four distinct nk sub popul nk subtyp correspond differ nk phenotyp secretori cytolyt one differ total nk percentag differ diseas form howev total number decreas signific survivor non survivor addit cd cd phenotyp observ differ pattern gradual decreas survivor gradual increas fatal outcom despit differ proport cd cd nk cell survivor vs non survivor main cytokin produc gradual declin studi period surviv group underl import adequ ifn product earli stage sar cov infect persist circul cd nk cell may prognost valu patient fatal outcom total nk cell cd cd nk subtyp exhibit signific decreas trend across moment survivor non survivor | D000086382;D007694 | T047;T025;T067 |
36,233,173 | normal aberr tale class homeobox gene activ pro b cell b cell precursor acut lymphoblast leukemia homeobox gene encod transcript factor regul basic development process arrang accord sequenc similar conserv homeobox class includ tale recent report call tale code gene signatur describ physiolog express pattern activ tale class homeobox gene cours hematopoiesi tale code allow evalu deregul tale homeobox gene leukemialymphoma extend tale code includ stage pro b cell pre b cell earli b cell develop detail analysi complet lineag b cell differenti reveal express tale homeobox gene irx mei exclus pro b cell furthermor identifi aberr express irx irx mei patient b cell precursor acut lymphoblast leukemia bcp origin earli b cell progenitor data show correl activ deregul tale class member particular bcp subtyp marker name irx tcfea fusion irx etvtel fusion mei kmtamll fusion correl also detect bcp cell line serv experiment model perform sirna mediat knockdown experi report gene assay analyz regulatori connect result show mutual activ irx tcf contrast irx direct repress wild type tcf fusion gene tcf pbx lost bind site irx remain unalt irx mutual activ fusion gene etv runx activ aberr express transcript factor klf final kmta activ mei turn support express irx summari reveal normal tale homeobox gene express earli b cell develop identifi aberr activ irx irx mei particular subtyp bcp thus tale homeobox gene may serv novel diagnost marker therapeut target | D015452;D054198 | T191 |
36,233,172 | transcript epigenom marker arteri venous micromacro vascular endotheli heterogen within umbil placent bed umbil placent vessel endotheli cell ec common model studi placent function vascular program arterio venous differ present umbil endothelium howev heterogen small placent vessel express potenti micro vs macro vascular mmv marker poor describ perform meta analysi transcriptom dna methyl data placent umbil ec express methyl profil compar use hierarch cluster dimension reduct ie tsne mds phate enrich analysi determin occurr arterio venous avh micro macro heterogen mmh cpg site correl gene express transcript marker mmh avh select lasso regress use ec discrimin general transcript profil result clear segreg ec specif origin mm avh group also observ microvascular marker appli altogeth meta analysi provid cogent evid regard transcript epigenom profil differenti among ec propos novel marker defin phenotyp base mm level | D042783;D010920 | T018;T025 |
36,233,171 | neuroprotect effect azithromycin follow induct optic nerv crush wild type immunodefici mice studi evalu potenti neuroprotect effect azithromycin az intraperiton inject male cbl wild type wt femal nod scid gamma nsg mice subject optic nerv crush onc model optic neuropathi histolog reduc apoptosi improv retin ganglion cell rgc preserv note az treat mice shown tunel stain wt mice nsg mice increas microgli activ follow onc reduc az treatment molecular analysi wt nsg mice similar trend detect regard apoptosi well stress relat inflammatori marker examin bcl associ x bax heme oxygenas ho interleukin beta il superoxid dismutas sod nuclear factor kappa b nfkb level optic nerv az increas level express sod nfkb wt mice decreas nsg mice retina wt nsg mice bax ho level express decreas follow az treatment sod nfkb express decreas wt mice remain stabl near baselin nsg mice il remain baselin wt mice decreas toward baselin az treat nsg mice neuroprotect effect demonstr reduc rgc apoptosi az treat wt mice retina optic nerv stress relat inflammatori gene express increas occur immunodefici nsg mice az modul inflammatori reaction microgli activ lack effect nsg mice support assumpt az act immunomodul known play role onc damag find implic develop repurpos drug preserv rgcs acut optic neuropathi | D018696;D020221 | T121;T169;T037 |
36,233,170 | regul airway smooth muscl cell prolifer diacylglycerol kinas relev airway remodel asthma airway remodel asthma involv hyperprolifer airway smooth muscl asm cell howev molecular signal regul asm growth complet understood gq coupl g protein coupl receptor receptor tyrosin kinas signal regul asm cell prolifer via activ phospholipas c generat inositol triphosph ip diacylglycerol dag diacylglycerol kinas dgk convert dag phosphatid acid pa termin dag signal promot pa mediat signal function herein hypothes pa pro mitogen second messeng asm dgk inhibit reduc convers dag pa result inhibit asm cell prolifer assess effect pharmacolog inhibit dgk pro mitogen signal prolifer primari human asm cell pretreat dgk inhibitor dgki signific inhibit platelet deriv growth factor stimul asm cell prolifer anti mitogen effect dgki associ decreas mtor signal express cyclin exogen pa promot pro mitogen signal rescu dgki induc attenu asm cell prolifer final hous dust mite hdm challeng wild type mice promot airway remodel featur attenu dgk mice propos dgk serv potenti drug target mitig airway remodel asthma | D056151;D001249 | T047;T046;T033 |
36,233,169 | short term mild hypoxia modul na k atpas maintain membran electrogenesi rat skelet muscl na k atpas play import role adapt hypoxia prolong hypoxia result loss skelet muscl mass structur perform howev hypox precondit known protect varieti function impair studi test possibl mild hypoxia modul na k atpas improv skelet muscl electrogenesi rat subject simul high altitud sea level hypobar hypoxia hh h use hypobar chamber isol diaphragm soleus muscl test diaphragm muscl hh increas na k atpas isozym electrogen activ stabli hyperpolar extrajunct membran h chang accompani steadi increas product thiobarbitur acid reactiv substanc well decreas serum level endogen ouabain specif ligand na k atpas hh also increas na k atpas membran abund without chang total protein content plasma membran lipid order phase chang soleus muscl hh protect disus hindlimb suspens induc sarcolemm depolar consid na k atpas critic maintain skelet muscl electrogenesi perform find may implic countermeasur disus induc patholog hypox therapi | D010042;D000254 | T121;T109;T126;T116 |
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