PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,234,685 | synthesi biolog evalu alo emodin coumarin hybrid potenti antitumor agent seri novel alo emodin coumarin hybrid design synthes antitumor activ deriv evalu five human tumor cell line sgc hepg mcf hct synthes compound exhibit moder good activ one cell line particular compound exhibit potent antiprolif activ refer drug etoposid test tumor cell line indic broad spectrum antitumor activ may provid promis lead compound develop antitumor agent structur modif furthermor structur activ relationship studi synthes compound also perform | D000504;D000970;D004642 | T121;T109;T123;T002 |
36,234,684 | recent progress techniqu detect aflatoxin b edibl oil mini review contamin agricultur product food aflatoxin b afb becom serious global problem presenc afb edibl oil frequent becom inevit especi underdevelop countri region afb result possibl degrad aflatoxin interact result toxic compound food compon could caus chronic diseas sever cancer increas morbid mortal therefor rapid reliabl detect method essenti check afb occurr foodstuff ensur food safeti recent new biosensor technolog becom research hotspot due characterist speed accuraci review describ various technolog chromatograph spectroscop techniqu elisa techniqu biosens techniqu along advantag weak afb control edibl oil provid new insight afb detect futur work although compar technolog biosensor technolog involv cross integr multipl technolog spectral technolog new nano materi great potenti challeng regard stabil cost etc need studi | D000348;D015374 | T059;T075;T109;T131 |
36,234,683 | mycobacterium time seri genom analysi identifi aac potenti drug target naloxon show potenti bait drug synerg world health organ put drug resist tuberculosi list signific threat critic emphasi resolv genet differ mycobacterium tuberculosi provid opportun better understand evolutionari progress lead anti microbi resist anti microbi resist great impact econom stabil global healthcar sector perform timelin genom analysi mycobacterium genom understand pattern under genom variat potenti drug target base function annot subject pharmacophor base screen fda approv phyto activ reaction search md simul metadynam studi perform total mutat transitiontransvers ratio observ top protein least number mutat high confid drug target aminoglycosid n acetyltransferas protein aac confer resist aminoglycosid shortlist potenti drug target base function role bait drug synerg gentamicin aac bind pose use pharmacophor templat screen phyto activ total potenti hit dock obtain naloxon lead activ dock score naloxon fda approv drug rapid revers opioid overdos classic case repurpos phyto activ naloxon consist amin group addit acetyl group unfavor reaction energi kcalmol gentamicin posit control molecular dynam simul studi perform ns check stabil bind metadynam base studi carri compar unbind energi gentamicin unbind energi found kcalmol naloxon gentamycin respect studi identifi naloxon potenti drug candid bait drug synergist approach mycobacterium tuberculosi | D009169;D014376 | T007;T047 |
36,234,681 | chrysomycin inhibit prolifer migrat invas u u mg glioblastoma cell exert anti cancer effect chrysomycin chr antibiot streptomyc report anti tumor anti tubercul activ anti glioblastoma activ possibl mechan clear therefor current studi investig mechan chr glioblastoma use u u mg human cell cck assay edu dna synthesi assay ldh assay carri detect cell viabil prolifer cytotox u u mg cell respect transwel assay perform detect invas migrat abil glioblastoma cell western blot use valid potenti protein chr treatment signific inhibit growth glioblastoma cell weaken abil cell migrat invas regul express slug mmp mmp furthermor chr also regul akt p akt gsk p gsk downstream protein catenin c myc human glioblastoma cell conclus chr may inhibit prolifer migrat invas glioblastoma cell aktgsk catenin signal pathway | D005909;D051176 | T191;T123;T116 |
36,234,680 | dusp silenc enhanc sensit breast cancer cell doxorubicin activ jnkc jun signal pathway doxorubicin dox limit effici breast cancer bc due drug acquir resist epitheli mesenchym transit emt play major role surviv drug resist cancer cell suggest jnk pathway implic respons dox regul emt duspor mkp well known regul jnk pathway found high express bc howev function signific yet fulli understood present studi possibl involv mkp dox induc emt investig breast cancer cell immunohistochemistri tissu obtain bc patient n reveal tissu stain posit mkp stain negat howev mkp protein express exhibit signific relationship bc prognost factor histolog grade histolog type hormon status ki marker express signific correl age mda mb cell dox induc phosphoryl jnk suffici enhanc mkp silenc cell result attenu dox induc emt cell cycl arrest ultim acceler apoptosi confirm acquisit dox sensit mkp silenc larg depend stimul jnk pathway inde result show overexpress mkp non tumorigen mcf cell dramat inhibit dox induc jnk activ subsequ cell death present studi knowledg first provid evid potenti role mkp chemoresist dox modul jnk pathway enhanc emt | D001943 | T191 |
36,234,679 | comprehens literatur review cardioprotect effect bioactiv compound present fruit aristotelia chilensi stuntz maqui fruit veget rich bioactiv compound polyphenol flavonoid anthocyanin may inhibit platelet activ pathway therefor reduc risk suffer cvd consum regular aristotelia chilensi stuntz maqui shrub tree nativ chile outstand antioxid activ associ high content anthocyanin polyphenol flavonoid previous studi reveal differ pharmacolog properti berri cardioprotect potenti littl studi despit abund composit rich bioactiv product antiplatelet role studi link berri antiplatelet activ review summar discuss relev inform cardioprotect potenti maqui base composit bioactiv compound main nutraceut antiplatelet agent articl publish follow bibliograph databas select pubm sciencedirect googl scholar search reveal maqui promis cardiovascular target sinc extract berri direct effect reduct cardiovascular risk factor glucos index obes diabet among other although studi antiplatelet activ fruit recent rich chemic composit clear show presenc chemic compound anthocyanin flavonoid phenol acid among other high antiplatelet potenti provid berri antiplatelet properti bioactiv compound antiplatelet effect multipl target platelet particular relat inhibit thromboxan thrombin adp gpvi receptor pathway receptor stimul platelet aggreg detail studi need clarifi gap literatur well specif evalu mechan action maqui extract due presenc phenol compound | D045467;D005638 | T168;T002 |
36,234,678 | natur product therapeut properti beyond ii histor natur product contribut drug discoveri sourc activ molecul due great divers structur complex | D001688 | T121;T123 |
36,234,676 | concurr determin tigecyclin tetracyclin epim deriv chicken muscl isol revers phase chromatographi system use tandem mass spectrometri quantit qualit method use high perform liquid chromatographi tandem mass spectrometri hplc msms detect approach develop valid analysi tigecyclin four tetracyclin three epim deriv chicken muscl sampl extract repeat moll na edta mcilvain buffer solut vortex centrifug solid phase extract evapor reconstitut aliquot separ use c revers phase column mm mm binari solvent system consist methanol moll trichloroacet acid aqueous solut typic valid paramet evalu accord accept criteria detail guidelin eu commiss decis ec us food drug administr bioanalyt method valid matrix match calibr curv linear concentr rang limit quantit loq gkg doxycyclin calibr graph tetracyclin chlortetracyclin oxytetracyclin epim deriv tigecyclin show good linear relationship within concentr rang loq gkg limit detect lod eight target rang gkg recoveri fortifi blank sampl rang within run precis run precis express relat standard deviat less respect applic success demonstr determin residu commerci chicken sampl purchas differ sourc approach provid novel option detect residu anim deriv food safeti monitor | D002751;D010118 | T109;T195 |
36,234,675 | new thiazol acet acid deriv studi screen cardiovascular activ use isol rat heart blood vessel cardiovascular diseas one major caus mortal worldwid present research new synthet deriv thiazol studi use isol heart blood vessel rat heart thorac aorta test six new synthes thiazol acet acid deriv smva smva smva smva smva smva data obtain statist analyz compar isol rat heart use record chang develop tension heart rate thorac aorta use measur contractil respons treatment analysi result indic signific p lt increas develop tension addit smva smva smva smva augment presenc adrenalin without affect heart rate hand acetylcholin signific decreas develop tension signific revers p lt presenc compound smva smva howev presenc smva smva acetylcholin induc bradycardia signific p lt reduc furthermor smva induc dose depend contractil respons isol blood vessel abolish presenc prazosin therefor conclud new synthes thiazol deriv exhibit promis result rais develop tension without chang heart rate blood vessel function could help fail heart condit howev research requir fulli comprehend function mechan effect compound | D019342;D013844 | T121;T109;T130 |
36,233,359 | hfr bhlh transcript regul arabidopsi thaliana improv grain yield shade osmot stress toler common wheat common wheat triticum aestivum wide grown stapl crop worldwid catch increas global popul cope chang climat valuabl breed wheat cultivar toler abiot shade stress densiti farm arabidopsi long hypocotyl far red athfr photomorphogenesi promot factor involv multipl light relat signal pathway inhibit seedl etiol shade avoid report overexpress athfr wheat inhibit etiol phenotyp various light shade condit lead shorten plant height increas spike number relat non transgen plant field ectop express athfr wheat increas transcript level tacab tach observ previous arabidopsi indic athfr transgen activ light signal transduct pathway wheat athfr transgen seedl signific exhibit toler osmot stress seed germin compar non transgen wheat athfr transgen repress transcript taft taco taco delay develop shoot apex head wheat furthermor athfr transgen wheat inhibit transcript level phytochrom interact factor like tapil tapil b tapil downregul target gene staygreen tasgr thus delay dark induc leaf senesc field grain yield three athfr transgen line higher non transgen wheat summari genet modif light signal pathway use photomorphogenesi promot factor posit effect grain yield due chang plant architectur resourc alloc enhanc toler osmot stress shade avoid respons | D017360;D029681;D010834 | T123;T116;T002 |
36,233,358 | lung tumor cell differ tn antigen express present distinct immunomodulatori properti lung cancer first lead caus cancer relat death world aberr glycosyl lung tumor lead express tumor associ carbohydr structur tn antigen consist n acetyl galactosamin galnac link serin threonin residu protein galnac serthr tn antigen recogn macrophag galactosegalnac lectin mgl mediat various immun regulatori tolerogen function main reprogram matur function dendrit cell dcs work generat two differ tn express variant lewi type lung murin cancer cell line show differ alter glycosyl pathway influenc interact mous mgl immunomodulatori properti dcs thus identif biolog program trigger tn cancer cell might contribut improv understand molecular mechan elicit mgl depend immun regulatori circuit | D005690;D008175 | T191;T109;T123 |
36,233,357 | decreas prosaposin progranulin cingul cortex associ schizophrenia pathophysiolog prosaposin psap progranulin pgrn two lysosom protein interact modul metabol lipid particular sphingolipid alter sphingolipid metabol found schizophrenia genet associ psap pgrn schizophrenia report clarifi role psap pgrn schizophrenia examin psap pgrn level postmortem cingul cortex tissu healthi control along patient suffer schizophrenia bipolar disord major depress disord found psap pgrn level reduc specif schizophrenia patient understand role psap cingul cortex use aav strategi knock psap neuron locat region neuron psap knockdown led downregul neuron pgrn level behavior abnorm cingul psap defici mice exhibit increas anxieti like behavior impair prepuls inhibit well intact locomot work memori depress like state behavior chang accompani increas earli growth respons protein egr activ depend cytoskeleton associ protein arc level sensorimotor cortex hippocampus region implic circuitri dysfunct schizophrenia conclus psap pgrn downregul cingul cortex associ schizophrenia pathophysiolog | D003865;D000077153;D049231;D012559 | T121;T123;T116;T048 |
36,233,356 | use urinari biomark assess bladder condit histopatholog patient interstiti cystitisbladd pain syndrom studi investig use urinari biomark assess bladder condit histopatholog patient interstiti cystitisbladd pain syndrom icbp retrospect enrol patient women men diagnos icbp control data clinic urodynam characterist visual analog scale vas score bladder capac cystoscop hydrodistent find hunner lesion glomerul grade maxim bladder capac mbc record urin sampl util assay inflammatori neurogen oxid stress biomark includ interleukin il c x c motif chemokin ligand cxcl monocyt chemoattract protein mcp brain deriv neurotroph factor bdnf eotaxin il macrophag inflammatori protein beta mip regul activ normal cell express secret rant tumor necrosi factor alpha tnf prostaglandin e pge hydroxi deoxyguanosin ohdg isoproatan total antioxid capac specif histopatholog find identifi via bladder biopsi associ urinari biomark level bladder condit histopatholog find evalu result reveal patient icbp signific higher urinari mcp eotaxin tnf pge ohdg isoprostan level control patient hunner ic hic signific higher il cxcl bdnf eotaxin il mip rant level non hunner ic nhic patient nhic mbc ml signific high urinari cxcl mcp eotaxin il mip rant pge isoprostan level total antioxid capac patient nhic higher glomerul grade signific high urinari mcp il rant ohdg isoprostan level signific associ observ urinari biomark glomerul grade mbc vas score bladder sensat howev bladder specif histopatholog find well correl urinari biomark level urinari biomark level use identifi hic differ nhic subtyp higher urinari inflammatori oxid stress biomark level associ icbp urinari biomark correl specif bladder histopatholog find nevertheless import assess bladder condit bladder histopatholog | D018856 | T047 |
36,233,355 | inflammatori prothrombot biomark dna polymorph microrna person medicin patient peripher arteri diseas classic risk factor play major role initi develop atherosclerosi howev estim risk cardiovascular event base risk factor often insuffici effort made identifi biomark indic ongo atherosclerosi among import circul biomark associ peripher arteri diseas pad inflammatori marker determin express differ gene epigenet process among proinflammatori molecul interleukin c reactiv protein sever adhes molecul cd ligand osteoprotegerin other associ presenc progress pad addit sever circul prothrombot marker predict valu pad genet polymorph signific albeit moder affect risk factor pad via alter lipoprotein metabol diabet arteri hypertens smoke inflamm thrombosi howev risk variant pad locat noncod region genom influenc gene express remain explor microrna mirna singl strand noncod rnas modul gene express post transcript level pattern mirna express extent vari differ atherosclerot cardiovascular diseas mirna appear use detect pad predict progress revascular outcom conclus take account one predisposit pad ie dna polymorph mirna togeth circul inflammatori coagul marker hold promis accur predict model person therapeut option | D050197;D035683;D058729 | T047;T046;T123;T114 |
36,233,354 | natur variat fatti acid desaturas gene affect linolen acid content starch past viscos rice grain rice one main food crop provid vital sourc dietari energi half world popul osfad gene encod fatti acid desaturas catalyz convers linol acid la alpha linolen acid ala rice howev genet character osfad role convers la ala remain elus valid effect two homolog gene osfad osfad ala laala ratio rice grain use near isogen line two major haplotyp osfad identifi differ effect ala laala ratio rice germplasm high express osfad associ high ala accumul eat qualiti rice grain overexpress osfad driven seed specif promot increas ala content fold endosperm diagnost marker design base bp insertiondelet osfad promot recogn osfad allel rice result indic osfad use target gene marker assist breed program improv varieti high ala appropri laala ratio brown rice | D012275;D017962 | T002;T121;T109;T123;T168 |
36,233,353 | circcsd regul prolifer differenti cc myoblast spong mir p growth develop skelet muscl regul mani factor recent studi shown circular rnas circrna particip process model porcin skelet muscl injuri construct search circrna regul growth develop skelet muscl pig use whole transcriptom sequenc bioinformat analysi novel circrna circcsd screen high express skelet muscl function studi cc cell demonstr circcsd could promot prolifer inhibit myoblast differenti oppos chang observ circcsd knockdown dual luciferas report assay reveal circcsd direct target mir p regul express downstream target gene cyclin depend kinas cdk moreov mir p could inhibit prolifer promot myoblast differenti cc cell opposit effect circcsd addit rescu experi offer evid circcsd target mir p work togeth regul myoblast prolifer differenti studi provid theoret basi understand regulatori mechan circrna | D035683;D000079962 | T123;T114 |
36,233,352 | biotechnolog advanc improv abiot stress toler crop major challeng agricultur face twenti first centuri increas drought water scarciti flood poorer soil extrem temperatur due climat chang howev crop toler extrem climat environ aim near futur world hunger increas popul breed andor engin crop toler abiot stress higher yield crop varieti display certain degre toler exploit plant breeder develop varieti thrive stress condit moreov long list gene involv abiot stress toler identifi character molecular techniqu overexpress individu plant transform experi nevertheless stress toler phenotyp polygenet trait current genom tool dissect exploit use acceler genet introgress use molecular marker site direct mutagenesi crispr cas review describ plant mechan sens toler advers climat condit examin discuss classic new molecular tool select improv abiot stress toler major crop | D018556;D000069600 | T040;T002 |
36,233,351 | erythropoietin receptor epor signal osteoclast lineag contribut epo induc bone loss mice erythropoietin epo pleiotrop cytokin classic drive erythropoiesi also induc bone loss decreas bone format increas resorpt delet epo receptor epor osteoblast b cell partial mitig skelet effect epo therebi implic contribut epor cell lineag studi design defin role monocyt epor epo mediat bone loss use two mous line condit delet epor monocyt lineag low dose epo attenu reduct bone volum bvtv cxcr cre epor ff femal mice compar control differ statist signific valid find increas epo dose lysm cre model mice model common use target preosteoclast signific reduct increas proport bone marrow preosteoclast cd observ follow high dose epo administr result bone loss lysm cre epor ff femal mice reduct bvtv compar control without interfer erythropoiet activ data suggest epor monocyt lineag least partial respons drive effect epo bone mass | D004921;D017467 | T121;T116;T125;T192 |
36,233,350 | label free enrich circul tumor plasma cell futur potenti applic dielectrophoresi multipl myeloma multipl myeloma mm circul tumor plasma cell ctpcs emerg prognost factor offer promis minim invas mean longitudin patient monitor recent advanc highlight complex biolog plasma cell traffick highlight phenotyp genet signatur intra extra medullari mm onset make ctpc enumer character new frontier precis medicin mm patient requir novel technolog platform standard harmon detect dielectrophoresi dep emerg label free cell manipul techniqu separ cancer cell healthi cell peripher blood sampl base phenotyp membran capacit could success test enumer isol ctpcs herein summar preclin data dep develop ctpc detect well clinic research potenti | D009101;D009360 | T191;T025 |
36,233,349 | nutraceut base nanoformul breast ovarian cancer treatment differ strategi investig satisfactori treatment advanc breast cancer includ adjuv use omega polyunsatur fatti acid pufa nutrit compound shown possess potent anti inflammatori antiangiogen activ capac affect transduct pathwaysreceptor involv cell growth reprogram tumor microenviron omega pufa contain nanoformul design drug deliveri breast cancer shown potenti effect enclos drug enhanc drug deliveri target site minim drug induc side effect critic analyz result recent studi investig effect omega pufa contain nanoformul breast cancer anti neoplast efficaci omega pufa also convinc demonstr use preclin vivo model ovarian cancer result obtain critic analyz seem provid suffici rational move still lack intervent clinic trial well evalu possibl advantag enclos omega pufa drug deliveri nanosystem ovarian cancer futur perspect area also provid | D001943;D015525;D010051 | T191;T109;T123;T121 |
36,233,348 | biomark periodont differenti dna methyl gene express immun cell systemat review characterist epigenet profil periodont found peripher leukocyt denot impact system immun fact profil stand periodont low grade inflammatori diseas system effect also import sourc potenti valuabl clinic biomark system effect suscept inflammatori condit thus aim identifi relev gene test epigenet system biomark patient periodont base dna methyl pattern rna express profil peripher immun cell detail protocol design follow prefer report item systemat review meta analysi prisma guidelin cross section case control studi report potenti system biomark periodont peripher immun cell type includ dna methyl analyz leukocyt gene express polymorphonuclear mononuclear cell hypermethyl found tlr regul gene mapk myd ilr ripk fadd irakbp ppara earli stage periodont advanc stage present hypomethyl gene tgfbi vnn hladrb cxcl gene differenti express lymphocyt monocyt subject poor control diabet mellitus dyslipidemia periodont comparison control dab gene differenti overexpress periodont dyslipidemia peripher blood neutrophil periodont show differenti express gene periodont show increas ceruloplasmin gene express polymorphonuclear comparison control sever gene highlight role epigenet peripher inflammatori cell periodont could explor blood sourc biomark routin test | D050171;D010518 | T047;T046 |
36,233,347 | methionin lyas daidzein combin propyl l cystein sulfoxid target prodrug enzym system malign solid tumor xenograft purpos studi determin anticanc effect dipropyl thiosulfin produc situ pharmacolog pair conjug daidzein ch methionin lyas ec ch mgl dz substrat propyl l cystein sulfoxid propiin various solid tumor type vitro vivo mtt test use calcul ic valu ht colo hct colon cancer panc mia paca pancreat cancer rv du pc prostat cancer promis effect colon cancer cell vitro observ ht ic ic valu mia paca panc respect among prostat cancer cell rv sensit ic vivo antitumor activ pharmacolog pair studi ht sw panc mia paca rv subcutan xenograft balbc nude mice applic ch mgl dz propiin demonstr signific reduct tumor volum panc tgi p mia paca tgi p ht tgi p rv tgi p xenograft result suggest combin ch mgl dzpropiin abl suppress tumor growth vitro vivo use pharmacolog pair consid new strategi treatment solid tumor | D003110;D010190;D011355;D011471 | T191;T120 |
36,233,346 | new saccharin salt chlordiazepoxid structur physicochem examin sinc format organ salt improv solubl bioavail stabil activ pharmaceut ingredi aim work prepar organ salt chlordiazepoxid saccharin achiev goal saccharin salt chlordiazepoxid obtain physic mixtur compon grind small volum solvent crystal complet evapor solvent result salt examin method powder x ray diffract pxrd singl crystal x ray diffract scxrd differenti scan calorimetri dsc thermogravimetr analysi tga fourier transform infrar ft ir raman spectroscopi result studi prove saccharin salt chlordiazepoxid crystal orthorhomb p bca space group one chlordiazepoxid cation one saccharin anion asymmetr unit crystal titl compound chlordiazepoxid cation saccharin anion interact strong n ho hydrogen bond weak c ho hydrogen bond disappear n h band ft ir spectrum saccharin may indic shift proton toward chlordiazepoxid disappear aromat bond band chlordiazepoxid ring raman spectrum may suggest format intermolecular hydrogen bond chlordiazepoxid molecul melt point salt differ start compound thermal decomposit salt begin c show least two overlap stage mass loss summari result research show crystallin salt saccharin chlordiazepoxid obtain various method grind addit acetonitril crystal acetonitril mixtur methanol methylen chlorid | D002707;D012439 | T121;T109 |
36,233,345 | occurr capnophil lactic ferment hyperthermophil anaerob bacterium thermotoga sp strain rq capnophil lactic ferment clf anaplerot pathway exclus identifi anaerob hyperthermophil bacterium thermotoga neapolitana member order thermotogal co activ pathway enabl non competit synthesi hydrogen l lactic acid high yield make econom attract process bioenergi product work discov character clf thermotoga sp strain rq natur compet strain open new avenu molecular investig pathway evalu ferment product express analys key clf gene rt pcr reveal similar clf phenotyp neapolitana sp strain rq absent non clf perform strain maritima key clf enzym pfor hyd ldh rnf nfn regul two clf strain anoth import find regul v atpas coupl atp hydrolysi proton transport across membran two clf perform strain fact v atpas absent maritima suggest enzym play key role maintain necessari proton gradient support high demand reduc equival simultan hydrogen lactic acid synthesi clf | D002245;D000084444 | T007;T123;T197 |
36,233,344 | lipid droplet format regul serthr phosphatas ppmd via dephosphoryl perilipin hypertrophi hyperplasia white adipocyt induc obes lead diseas type diabet hypertens even cancer hypertrophi white adipocyt attribut excess storag energi form triglycerid lipid droplet lds lds fat storag organell maintain whole bodi energi homeostasi import understand mechan ld format develop obes therapi howev regulatori mechan ld size format fulli understood studi demonstr ppm famili phosphatas ppmd regul ld format ppmd specif inhibitor sl signific decreas ld format via two differ pathway depend independ adipocyt differenti process matur white adipocyt differenti ld format found control ppmd via dephosphoryl ser perilipin found inhibit ppmd matur white adipocyt signific reduc size lds via dephosphoryl ser perilipin chang lipolysi sensit total amount lipid cell collect result studi provid evid ppmd play import role ld format matur adipocyt | D003924;D066292;D000071636 | T047;T026;T126;T116 |
36,233,343 | cas photosynthet organ carbon anhydras cas ubiquit enzym catalyz revers carbon dioxid hydrat reaction among eight differ ca class exist natur class largest one present anim bacteria protozoa fungi photosynthet organ although mani studi report enzym function biochem structur data current avail cas isol photosynthet organ give overview recent literatur topic higher plant enzym engag suppli co rubisco determin proton concentr psii membran alga cyanobacteria involv carbon concentr mechan ccm photosynthet reaction detect signal chang co level environ crystal structur avail three algal cas thus allow associ specif structur featur cellular local physiolog role therefor studi cas photosynthet organ strong need provid insight structur function relationship | D002256 | T126;T116 |
36,233,342 | rai promot melanoma progress regul fbxoc myc pathway melanoma origin malign transform melanocyt compar skin cancer melanoma higher fatal rate year surviv rate patient earli stage primari melanoma surgic resect reach howev year surviv rate patient metastat melanoma therefor accur assess melanoma progress critic previous studi found retino acid induc rai critic tumorigenesi howev biolog function rai develop melanoma unclear studi rai high express melanoma correl prognosi express rai affect prolifer migrat invas melanoma cell f box protein fbxo e ubiquitin ligas c myc found rai affect transcript express fbxo regul stabil c myc result suggest rai play import role growth melanoma expect therapeut target melanoma | D003598;D044783;D008545;D012878;D014157 | T191;T123;T116 |
36,233,341 | heme oxygenas therapeut target diabet foot ulcer diabet foot ulcer dfu one major complic diabet wound heal diabet condit often impair part due excess oxid stress prolong inflamm immun cell dysfunct delay epitheli decreas angiogenesi present wound site result multifactori impair heal pathway difficult develop effect therapeut strategi dfu heme oxygenas ho rate limit enzym heme degrad generat carbon monoxid co biliverdin bv convert bilirubin br iron ho potent antioxid act anti inflammatori prolif angiogen cytoprotect enzym due biolog function ho play import role wound heal part mediat biolog activ end product generat enzymat activ particular co bv br therapeut strategi involv activ ho topic applic biolog activ end product import diabet wound heal therefor ho attract therapeut target dfu treatment review provid overview discuss import ho therapeut target diabet wound heal | D003920;D017719 | T047 |
36,233,340 | sequenc characterist express analysi ghcipk gene upland cotton gossypium hirsutum l cipk calcineurin b like interact protein kinas kind serinethreonin protein kinas wide exist plant play import role plant growth develop stress respons better understand biolog function ghcipk gene upland cotton code sequenc cds ghcipk gene clone upland cotton protein sequenc evolutionari relationship subcellular local express pattern cis act element promot region analyz result show full length cds ghcipk bp encod protein amino acid molecular weight isoelectr point protein kda respect ghcipk protein contain conserv n termin protein kinas domain c termin regulatori domain cipk gene famili member phylogenet tree analysi demonstr ghcipk close relationship atcipk follow oscipk belong group atcipk oscipk subcellular local experi indic ghcipk locat plasma membran tissu express analysi show ghcipk highest express petal follow sepal lowest fiber stress express analysi show express ghcipk gene respons drought salt low temperatur exogen abscis acid aba treatment differ express pattern differ stress condit cis act element analysi show ghcipk promot region cis act element respons abiot stress phytohormon light result establish foundat understand function ghcipk breed varieti high stress toler cotton | D003368;D010937 | T125;T116;T002 |
36,233,339 | molecular biomark earli detect ovarian cancer ovarian cancer deadliest gynecolog cancer lead death year late diagnosi primari factor caus poor prognosi ovarian cancer often occur due lack specif symptom effect biomark earli detect current cancer antigen ca wide use biomark ovarian cancer detect approach limit low specif recent year multimark panel develop combin molecular biomark human epididymi secretori protein ultrasound result menopaus status improv diagnost efficaci risk ovarian malign algorithm roma risk malign index rmi ova assay also clinic use improv sensit specif ongo investig novel biomark autoantibodi ctdnas mirna dna methyl signatur continu aim provid earlier detect method ovarian cancer paper review recent advanc molecular biomark earli detect ovarian cancer | D035683;D010051 | T191;T123;T114 |
36,233,338 | nanomedicin treat muscl dystrophi opportun challeng futur perspect muscular dystrophi group genet muscular diseas character impair muscl regener lead patholog inflamm drive muscl wast eventu result weak function depend prematur death known caus death includ respiratori muscl failur due diaphragm muscl decay definit treatment muscular dystrophi convent therapi aim amelior muscl wast promot physiolog muscl regener growth howev effect muscl function remain limit illustr requir major advanc novel approach treatment nanomedicin nanomedicin rapid evolv field seek optim drug deliveri target tissu merg pharmaceut biomed scienc howev therapeut potenti nanomedicin muscular dystrophi poor understood review highlight recent work applic nanomedicin treat muscular dystrophi first discuss histori applic nanomedicin broader perspect second address use nanoparticl drug deliveri gene regul edit target duchenn muscular dystrophi myoton dystrophi next highlight potenti hindranc limit use nanomedicin context cell cultur anim model final futur perspect use nanomedicin clinic summar relev muscular dystrophi | D020388;D009223 | T047 |
36,233,337 | microsporum gypseum isol ailuropoda melanoleuca provok inflamm trigger th adapt immun respons microsporum gypseum caus dermatomycos giant panda ailuropoda melanoleuca studi aim investig immun respons gypseum follow deep infect degre damag heart liver spleen lung kidney evalu use tissu fungal load organ index histopatholog method quantit revers transcript polymeras chain reaction qrt pcr detect mrna express receptor cytokin lung immunofluoresc stain flow cytometri use assess immun cell lung result indic conidia main colon lung caus serious injuri gypseum infect furthermor dectin tlr tlr play role recogn gypseum cell numer inflammatori cell main macrophag dendrit cell polymorphonuclear neutrophil inflammatori cytokin tgf tnf il il il il il activ earli stage infect high express il il il f th pathway exert adapt immun respons gypseum infect result potenti aid diagnosi treatment diseas caus gypseum giant panda | D056704;D020381;D008864;D058504;D001503 | T015;T116;T192;T123;T040;T129;T025;T004;T039 |
36,233,336 | transcriptom profil hippocamp seizur network implic role wnt signal epileptogenesi mous model tempor lobe epilepsi mesial tempor lobe epilepsi mtle life threaten condit character recurr hippocamp seizur mtle develop exposur risk factor febril seizur trauma infect within latent period exposur onset epilepsi patholog remodel event occur contribut epileptogenesi molecular mechan respons current unclear use mous intrahippocamp kainit model mtle investig transcript dysregul ipsilater contralater dentat gyrus dg repres epileptogen zone ez peri ictal zone piz dg analyz day rna sequenc ez piz transcript dysregul dynam epileptogen period earli express gene repres cell signal migrat prolifer canon wnt signal upregul ez piz day express inflammatori gene differ ez piz earli express day piz delay express day ez suggest critic gene chang occur earli hippocamp seizur network wnt signal may play role within latent epileptogen period find may help identifi novel therapeut target could prevent epileptogenesi | D004833 | T047 |
36,233,335 | identif glu allel novel marker trait associ flour qualiti grain yield trait heat stress environ wheat line deriv divers access aegilop tauschii heat stress grain fill consid one major abiot factor influenc wheat grain yield qualiti arid semi arid region studi effect heat stress flour qualiti grain yield moder continu heat stress natur field condit use line wheat multipl synthet deriv msd contain aegilop tauschii introgress studi aim identifi marker trait associ mtas qualiti trait grain yield heat stress condit identifi stress resili germplasm combin trait good flour qualiti grain yield msd line show consider genet variat qualiti trait grain yield heat stress condit line perform better recurr parent norin identifi two msd line consist maintain relat perform rp valu grain yield dough strength found presenc three high molecular weight glutenin subunit hmw gss glu locus deriv ae tauschii associ stabl dough strength across four environ use studi hmw gss could potenti use applic futur improv end use qualiti trait target wheat sever heat stress total high qualiti snp marker use genom wide associ analysi mtas identifi genom confirm power msd panel platform mine explor gene ae tauschii identifi mtas dough strength heat stress simultan control grain yield relat perform dough strength heat stressoptimum condit studi prove ae tauschii inexhaust resourc genet mine identifi line pleiotrop mtas report studi consid good resourc develop resili wheat cultivar combin good flour qualiti grain yield stress condit use marker assist select | D000078065;D014908 | T168;T002 |
36,233,334 | interact corf fama two ciliari protein essenti photoreceptor surviv mutat corf caus bardet biedl syndrom bbs retin pigmentosa rp cone rod dystrophi crd manifest photoreceptor degener littl known protein corf interact contribut photoreceptor surviv determin protein potenti interact corf carri yeast two hybrid yh screen use corf bait fama microtubul bind protein local photoreceptor cilium requir photoreceptor surviv identifi one prey doubl immunofluoresc stain proxim ligat assay pla marmoset retin section show corf enrich co local fama ciliari base photoreceptor epitop tag corf fama express hek cell also found co local doubl immunofluoresc stain pla furthermor interact domain map assay identifi n termin region corf amino acid residu within pfam upf domain fama critic corf fama interact data suggest two photoreceptor surviv protein corf fama interact may contribut photoreceptor health | D005136;D011506;D012174 | T047;T123;T116 |
36,233,333 | microbiom nodul root soybean common bean search differ associ contrast perform symbiot nitrogen fixat biolog nitrogen fixat bnf key process n input agricultur outstand econom environment benefit replac chemic fertil howev symbios equal effect fix n major exampl reli high contribut associ soybean glycin max contrast low rate report common bean phaseolus vulgari crop worldwid understand differ repres major challeng help design strategi increas contribut bnf next generat sequenc ngs analys nodul root microbiom may bring new insight explain differenti symbiot perform studi three treatment evalu non steril soil condit investig legum non inocul control ii inocul host compat rhizobia iii co inocul host compat rhizobia azospirillum brasilens effici specif symbiosi soybean bradyrhizobium present high abund nodul increas inocul contrarili abund main rhizobium symbiont lower common bean nodul increas inocul may explain often report lack respons legum inocul elit strain co inocul azospirillum decreas abund host compat rhizobia nodul probabl competit among speci rhizospher increas root microbiom result show sever bacteria compos nodul microbiom legum includ nitrogen fix growth promot biocontrol agent whose contribut plant growth deserv investig sever genera bacteria detect root microbiom microbi communiti might contribut plant growth varieti microbi process howev massiv inocul elit strain better investig may affect root microbiom verifi relat abund divers indic might impact contribut microbi process plant growth | D064307;D027805;D012231 | T002;T007;T028;T001;T168;T032 |
36,233,332 | genom wide identif erf transcript factor famili function analysi drought stress respons gene melilotus albus import forag legum high valu feed medicin melilotus albus wide cultiv aperf transcript factor shown play import regulatori role plant drought resist report legum forag crop albus digger gene albus respons drought stress identifi analyz erf gene famili albus genom wide level total maerf gene contain singl ap domain sequenc identifi studi name maerf maerf bioinformat analysi perform collinear analysi indic segment duplic may play key role expans albus erf gene famili cis act element predict suggest maerf gene involv various hormon respons abiot stress express pattern indic maerf respond drought stress vari degre furthermor four regul erf maerf maerf maerf maerf drought stress overexpress yeast indic biolog function confer toler drought work advanc understand molecular mechan under drought respons albus studi promis potenti candid gene identifi studi provid valuabl resourc next step function genom studi improv possibl improv drought toler albus transgen approach | D055864;D029903 | T002;T070 |
36,233,331 | enhanc bioactiv tailor made glycolipid enrich manuka honey glycolipid synthet deep eutect solvent dess possess low water content allow revers lipas activ thus enabl ester format base principl honey also serv media glycolipid synthesi inde supersatur sugar solut compar term physicochem properti sugar base dess honey base product commerci avail therapeut applic appear interest enhanc bioactiv current work investig enrich medic grade honey situ enzymat synthet glycolipid improv antimicrobi properti mixtur test mixtur compos manuka honey enrich octano decano laurat myrist sugar ester respect dub goh gdh glh gmh character bioactiv mixtur first qualit screen use agar well diffus assay perform methicillin resist staphylococcus aureus bacillus subtili candida bombicola escherichia coli pseudomona putida confirm consider enhanc suscept micro organ differ glycolipid enrich honey mixtur design biosensor e coli strain display stress report system consist three stress specif induc red green blue fluoresc protein respect translat physiolog stress genotox cytotox use bioactiv therefor character six fold enhanc physiolog stress caus goh compar regular manuka honey v v concentr observ antibacteri agar well diffus assay e coli perform well demonstr improv inhibitori potenti goh upon v v concentr | D000890;D006722;D055624 | T121;T007;T168 |
36,233,330 | integr analysi nasal microbiota serum metabolit bovin respiratori diseas rrna sequenc gas chromatographymass select detector base metabolom bovin respiratori diseas brd continu pose serious threat cattl industri result substanti econom loss multifactori diseas pathogen infect respiratori microbi imbal import causat factor occurr develop brd integr analys rrna sequenc metabolom allow comprehens identif chang microbiota metabol associ brd make possibl determin pathogen respons diseas develop new therapeut strategi studi rrna sequenc metagenom analysi use describ compar composit divers nasal microb healthi cattl cattl brd differ farm yinchuan ningxia china found signific differ nasal microbi divers diseas healthi bovin notabl relat abund mycoplasma bovi pasteurella increas indic composit microbi communiti chang diseas bovin compar healthi one data also strong suggest reduc relat abund probiot includ pasteurellal lactobacillal diseas sampl contribut suscept bovin respiratori diseas furthermor serum metabolom analysi show alter concentr metabolit brd signific decreas lactic acid sarcosin may impair abil bovin generat energi immun respons pathogen bacteria base correl analysi microbi divers metabolom lactic acid tms posit correl gammaproteobacteria bacilli negat correl mollicut summari microbi communiti serum metabolit brd character integr analysi studi provid refer monitor biomark brd critic prevent treatment brd futur | D002418;D064307;D012120;D012140 | T001;T047;T032;T028 |
36,233,329 | nac transcript factor gmnac improv drought stress toler soybean nac transcript factor tfs could regul drought stress plant howev function nac tfs soybean remain unclear unravel nac tf function establish gmnac nac tf soybean glycin max involv manipul stress toler express gmnac signific upregul fold drought stress threefold abscis acid aba ethylen eth treatment order determin function gmnac drought stress condit generat gmnac overexpress knockout line present find show drought stress surviv rate gmnac overexpress line increas compar wild type plant surviv rate gmnac knockout line decreas least furthermor subcellular localis analysi show gmnac protein concentr nucleus tobacco cell addit use yeast two hybrid assay identifi protein interact gmnac gene ontolog go kegg analysi show gmnac interact protein relat chitin chlorophyl ubiquitin protein transferas peroxidas activ henc infer gmnac key gene could posit regul soybean toler drought stress | D055864;D013025 | T168;T070 |
36,233,328 | silver nanoparticl produc laser ablat irradi effect prevent peri implant multispeci biofilm format implant associ infect due biofilm format grow problem given silver nanoparticl ag nps shown antibacteri effect goal studi effect multispeci biofilm involv develop peri implant purpos ag nps synthes laser ablat de ioniz water use two differ laser lead product colloid suspens subsequ part suspens subject irradi one three time laser sourc obtain ag nps immobil surfac titanium disc result materi compar unmodifi titanium coupon nanoparticl physico chemic analys determin shape crystallin chemic composit mean diamet materi incub min h evalu bacteri adhes biofilm format respect staphylococcus aureus oral mix bacteri flora compos streptococcus orali actinomyc naeslundii veionella dispar porphyromona gingivali ag nps help prevent format biofilm aureus mix oral bacteri flora nanoparticl irradi three time show biggest antimicrobi effect modifi dental implant way could prevent develop peri implant | D015921;D053685;D053768;D057873;D000069475 | T061;T047;T074;T073 |
36,233,327 | group wrki gene tawrki negat regul drought resist transgen plant wrkys one largest transcript factor tf famili play import role plant resist various stress tawrki group wrki protein respond varieti abiot stress includ peg treatment tawrki protein locat nucleus tobacco epiderm cell n termin c termin domain exhibit transcript activ activ overexpress tawrki reduc drought toler arabidopsi thaliana reflect lower germin rate shorter root higher stomat apertur poorer growth lower antioxid enzym activ drought treatment moreov express level stress relat gene dreba rda rdb abf aba abi sod cuzn pod cat downregul transgen arabidopsi drought stress gene silenc tawrki enhanc drought toler wheat reflect better growth higher antioxid enzym activ higher express level stress relat gene includ dreb dreb abf erf sod fe pod cat pcs conclus result suggest tawrki might reduc drought toler plant regul express stress relat gene | D017360;D055864 | T002;T070 |
36,233,326 | crystal design photoact tio nanorod templat decor nanostructur bi visibl light sensit studi tio bi composit various morpholog synthes hydrotherm vulcan sputter deposit bi sacrifici layer method tio nanorod templat morpholog decor bi nanostructur tio nanorod templat control durat hydrotherm vulcan treatment bi crystal lumpi filament nanowir nanorod featur decor tio nanorod templat h hydrotherm vulcan respect compar tio bi composit bi nanowir exhibit best photocurr densiti lowest interfaci resist valu highest photodegrad effici toward rhodamin b solut possibl z scheme photoinduc charg separ mechan suitabl morpholog bi nanowir might account high photoact tio nanorod bi nanowir composit | D049329;D043942 | T073 |
36,233,325 | waterborn eco sustain sol gel coat base phytic acid intercal graphen oxid corros protect metal surfac past year corros protect metal materi becom global challeng due great econom import reason various method develop inhibit corros process surfac treatment approach employ corros inhibitor deposit opportun design function coat employ preserv corros damag metal substrat recent among techniqu order avoid toxic chromat base pre treatment coat silan base coat film load organ inorgan corros inhibitor wide use corros mitig water base surfac treatment studi synthet approach devot creat embed host waterborn eco friend matrix obtain use sol gel techniqu reaction function alkoxysilan cross link precursor name glycidyloxypropyl trimethoxysilan gptms aminopropyl triethoxysilan apt presenc graphen oxid go intercal natur non toxic phytic acid pa molecul matter fact experiment result ft ir spectroscopi uv vis analysi sem confirm pa molecul success decor go furthermor polar measur neutral salt spray test use evalu anticorros perform aluminum steel substrat thus show go pa nanofil improv barrier corros protect properti develop function silan base coat | D010833;D012821 | T121;T109;T127;T130;T104 |
36,233,324 | transcript metabol character feed rami growth enhanc combin applic gibberellin ethrel feed rami cultivar boehmaria nivea l import feedstock livestock increas biomass improv nutrit valu essenti anim feed gibberellin ga ethylen eth two plant hormon regul growth develop metabol plant herein report effect ga eth applic growth plant metabol feed rami field combin ga eth design spray new plant two hormon enhanc growth plant produc biomass meanwhil two hormon reduc content lignin leav stem increas content flavonoid leav understand potenti mechan behind result use rna seq base transcriptom uplc msms base metabolom character gene express metabolit profil associ treatment ga eth differenti express gene deg obtain leav stem treat versus control respect meanwhil differenti accumul metabolit dam annot treat versus control leav treat versus control stem respect data mine reveal deg dam associ multipl plant metabol especi plant secondari metabol specif focus plant phenylpropanoid pathway identifi candid deg dem associ lignin flavonoid biosynthesi shikim hydroxycinnamoyl transferas hct key enzym involv lignin biosynthesi gene encod b nivea hct downregul treat leav stem addit gene encod coumaryl coa ligas cl tran cinnam monooxygenas cypa two lignin pathway enzym downregul treat stem meanwhil reduct lignin treat leav led increas cinnam acid p coumaryl coa two share substrat flavonoid enhanc content taken togeth find indic appropri combin ga eth effect strategi enhanc plant growth via alter gene express plant secondari metabol biomass enhanc valu improv feed rami | D032402;D005875 | T109;T123;T002 |
36,233,323 | non coval interact crystal structur perbromin sulfonium deriv closo decabor anion new seri compound base perbromin disubstitut sulfonium deriv closo decabor anion n bu n b br sr r n pr pr n bu n c h n c h n c h obtain characteris modern physicochem method analysi accord result x ray diffract studi anion solvat molecul disord cation n bu n anion b br sr associ via c hbr hh contact addit brbr interact anion reveal role contact analys term hirshfeld surfac analysi qtaim theori nci method use quantum chemic calcul increas size alkyl r moieti led signific strengthen total energi hh interact case r n c h parallel mutual orient alkyl moieti establish similar pack salt fatti acid natur c hbr brbr interion interact found attract contrast repuls natur intermolecular brbr interact | D005227;D012492 | T104;T109;T123;T168 |
36,233,322 | desmin knock cardiomyopathi heart verg metabol crisi desmin mutat caus famili sporad cardiomyopathi addit perturb contractil apparatus desmin defici mutat desmin negat impact mitochondria impair myocardi metabol secondari mitochondri defect could conceiv exacerb cardiac contractil dysfunct perform metabol myocardi phenotyp left ventricular cardiac muscl tissu desmin knock mice analys reveal decreas mitochondri number ultrastructur mitochondri defect impair mitochondria relat metabol pathway includ fatti acid transport activ catabol glucos transport hexokinas express hexokinas activ increas mitochondri creatin kinas express reduc fetal creatin kinas express increas proteom analysi reveal reduc express protein involv electron transport main complex ii oxid phosphoryl citrat cycl beta oxid includ auxiliari pathway amino acid catabol redox reaction oxid stress thus desmin defici elicit secondari cardiac mitochondriopathi sever impair oxid phosphoryl fatti amino acid metabol increas glucos util fetal creatin kinas upregul like portray attempt maintain myocardi energi suppli may prudent avoid medic worsen mitochondri function metabol stressor therapeut intervent mitochondriopathi might also improv metabol condit desmin defici heart | D009202;D003893;D006593 | T126;T047;T123;T116 |
36,233,321 | polysaccharid isol herb bletilla striata combin methylcellulos form hydrogel via self assembl wound dress bletilla striata polysaccharid bsp natur polysaccharid deriv east asian terrestri orchid bletilla striata anti inflammatori antivir antioxid polysaccharid tradit use treat hemostasi wound heal studi bsp blend methylcellulos mc methylparaben mp creat hydrogel self assembl rout wound dress develop hydrogel design mb x mb x mb x stand mc number repres percentag wherea second letter b stand bsp x refer percentag variat bsp x develop mb hydrogel contain glucopyranosyl mannopyranosyl rheolog test tan valu pore size hydrogel decreas increas mc bsp content better properti respect water loss swell ratio evalu vitro vivo show develop mb hydrogel good cell viabil wound heal properti mb hydrogel group found superior other within develop mb hydrogel therefor believ mb hydrogel formul high potenti develop wound dress | D020100;D029595 | T002;T122 |
36,233,320 | anti c met fab grb gab fusion protein mediat interfer c met signal pathway induc methuosi tumor cell bio macromolecul potenti applic cancer treatment due high select effici hit therapeut target howev poor cell membran permeabl limit broad spectrum applic cancer treatment current studi develop high internaliz anti c met antibodi fab fusion protein intracellular epitop peptid chimera achiev dual intervent extracellular intracellular target tumor therapi vitro experi demonstr fusion protein could interfer diseas associ intracellular signal pathway inhibit uncontrol prolifer tumor cell import investig under mechan reveal protein chimera could induc vacuol treat cell thus interf normal extens arrang microtubul well mitosi lead induct methuosi mediat cell death furthermor vivo tumor model indic certain dose fusion protein could inhibit xenograft tumor nod scid mice studi thus provid new idea intracellular deliveri bio macromolecul dual intervent tumor cell signal pathway | D019859;D015398 | T116;T192;T126;T043;T044 |
36,233,319 | molecular character er allel confer resist erysiph pisi three chines pea pisum sativum l landrac powderi mildew caus erysiph pisi dc major diseas affect pea worldwid studi aim confirm resist gene contain three powderi mildew resist chines pea landrac suoshadabaiwan dabaiwandou guiwan develop function marker novel resist gene resist gene identifi genet map psmlo gene sequenc identif confirm inherit powderi mildew resist three landrac suscept cultivar bawan longwan chengwan cross suoshadabaiwan dabaiwandou guiwan produc f f f popul respect f plant suscept e pisi phenotyp segreg pattern f f popul fit suscept resist suscept homozygot heterozygot resist homozygot ratio respect indic powderi mildew resist three landrac control singl recess gene respect analysi er link marker genet map f popul suggest recess resist gene three landrac could er allel cdna sequenc homolog psmlo cdna clone contrast parent obtain known er allel er identifi suoshadabaiwan two novel er allel identifi dabaiwandou guiwan design er er respect novel allel character bp delet posit exon exon respect caus frame shift mutat result prematur termin translat psmlo protein co domin function marker specif er er kaspar er kaspar er develop effect valid popul pea germplasm two novel er allel character function marker valid result provid power tool marker assist select pea breed | D001203;D018532 | T168;T004;T002 |
36,233,318 | lipidom profil patient low bone miner densiti lbmd relationship lipid metabol bone miner densiti bmd still fulli elucid despit presenc investig use osteoporot anim model clinic studi human limit work untarget lipidom profil use liquid chromatographi mass spectrometri lc ms analysi human serum sampl perform identifi lipidom profil associ low bone miner densiti lbmd subsequ examin potenti biomark relat op risk predict progress total particip recruit cohort studi includ osteoporot group op n osteopenia group n control ctrl n lbmd group includ op patient lipidom effect confound factor age gender lipid profil bodi mass index bmd chronic diseas medic exclud dataset result show clear group separ cluster lbmd ctrl q r indic signific differ lipid profil addit putat identifi lipid molecul dysregul regul lbmd compar ctrl signific dysregul subclass phosphatidylcholin pc n dysregul lipid follow triacylglycerol tg n phosphatidylethanolamin pe n addit group glycerophospholipid includ lpc lpe pi also dysregul lbmd find provid insight lipidom alter involv bone remodel lbmd may drive develop therapeut target nutrit strategi op manag | D001851;D000081362 | T047;T091;T109 |
36,233,317 | antivir compound screen target hbx protein hepat b virus function cure hepat b virus hbv infect hb antigen loss rare achiev nucleo ide analog target viral polymeras hbx protein regulatori protein associ hbv replic thought identifi antivir compound target hbx protein analyz hbx bind activ recombin gst tag hbx protein appli fda approv drug librari chip includ compound determin bind affin surfac plasmon reson imag spri use plexarray ht system gst protein alon use control experi candid compound test anti hbv activ well cell viabil use hepg cell hbv infect human hepatocyt compound screen compound show bind hbx protein top compound high affin hbx protein tranilast found inhibit hbv replic without affect cell viabil use hepg cell tranilast also inhibit hbv infect use cultur human hepatocyt tranilast reduc hb antigen level dose depend overal thespri screen assay identifi novel drug candid target hbx protein tranilast relat compound warrant investig treatment hbv infect | D006509;D006515 | T047;T005 |
36,233,316 | molecular event rice aperf transcript factor apetalaethylen respons factor aperf wide found plant kingdom play crucial role transcript regul defens respons plant growth develop base research progress relat aperf gene paper focus classif structur featur aperf transcript factor review role rice aperf gene regul growth develop stress respons discuss rice breed potenti challeng taken togeth studi rice aperf gene may help elucid enrich multipl molecular mechan aperf gene regul spikelet determinaci floral organ develop flower time grain size qualiti embryogenesi root develop hormon balanc nutrient use effici biotic abiot respons process contribut breed excel rice varieti high yield high resist green organ manner | D012275;D014157 | T123;T168;T116;T002 |
36,233,315 | virus associ nephropathi narrat review viral infect caus mild symptom spontan favor resolut lead sever protract manifest specif immunocompromis host kidney injuri relat viral infect may multipl caus relat infect sever drug toxic direct indirect viral associ nephropathi review describ virus associ nephropathi order guid diagnosi strategi treatment case acut kidney injuri aki occur concomit viral infect occurr virus associ nephropathi depend multipl factor local epidemiolog virus abil infect renal cell patient under immun respons vari state immunosuppress clear comprehens pathophysiolog mechan associ summari describ direct indirect injuri help physician diagnos treat viral associ nephropathi | D058186;D016030;D014777 | T061;T047;T037 |
36,233,314 | target crosstalk immun respons vascular smooth muscl cell phenotyp switch arterioven fistula matur plaqu format thrombosi embol under caus acut cardiovascular event myocardi infarct stroke earli thrombosi stenosi common patholog matur failur arterioven fistula avf chronic inflamm common under pathogenesi mediat innat adapt immun respons involv infiltr immun cell secret pro anti inflammatori cytokin impair immun cell infiltr chang vascular smooth muscl cell vsmc phenotyp play crucial role under pathophysiolog howev chang phenotyp vsmcs microenviron immun cell infiltr increas secret cytokin investig sinc chang vsmc phenotyp regul vessel remodel intim injuri studi investig effect macrophag pro inflammatori cytokin il il tnf chang vsmc phenotyp vitro condit also investig express marker vsmc phenotyp arteri atherosclerot plaqu vsmcs isol control arteri found inhibit cytokin downstream signal may mitig effect cytokin chang vsmcs phenotyp result studi support regul target immun cell infiltr function might therapeut strategi mitig effect chronic inflamm attenu plaqu format earli thrombosi stenosi thus enhanc avf matur | D001164;D009131 | T024;T190 |
36,233,313 | involv smooth muscl striat muscl myocardium scleroderma review system sclerosi ssc complex autoimmun diseas character heterogen chang involv numer organ system current avail data indic muscl injuri smooth striat muscl widespread lead signific morbid either direct indirect consequ smooth muscl involv tunica media blood vessel level digest tract skelet myopathi may interpret strict context ssc overlap idiopath inflammatori myopathi muscular injuri scleroderma translat number notabl clinic manifest heart involv ssc heterogen depend definit use various studi major ssc patient experi silent form cardiac diseas present review summar certain import featur myocardi well smooth skelet muscl involv ssc research need fulli describ understand pathogen pathway implic muscl involv scleroderma | D009135;D012595 | T047 |
36,233,312 | ido modul sensit epitheli ovarian cancer cell cisplatin rosp depend apoptosi indoleamin dioxygenas ido heme contain dioxygenas may play part chemoresist ovarian cancer howev role cisplatin ddp resist unclear express level ido tumor platinum resist n sensit n ovarian cancer patient determin ido modul ddp resist explor vitro vivo ido express level platinum resist patient higher sensit patient higher ido level correl poor prognosi type ii cancer patient regul ido decreas ddp induc apoptosi skov cell via inhibit rosp cell death pathway therebi attenu cytotox ddp silenc ido enhanc p depend apoptosi increas ros accumul therebi enhanc ddp skov cell knock ido augment action ddp vivo data demonstr silenc ido enhanc efficaci ddp intensifi p depend apoptosi target ido strategi modul ddp base chemotherapi epitheli ovarian cancer | D000970;D050503;D010051 | T116;T121;T191;T109;T126 |
36,233,311 | choroid vasculatur chang age relat macular degener molecular clinic perspect contribut choroid vasculatur pathogenesi age relat macular degener amd long debat present narrat review aim discuss primari molecular choroid structur chang occur age amd brief overview princip multimod imag modal techniqu enabl optim vivo visual choroid modif molecular aspect target choroid amd main involv human leukocyt antigen hla express complement dysregul leukocyt interact bruch membran mast cell infiltr choroid mechanist link high risk genet loci amd mast cell recruit also recent demonstr recent advanc multimod imag allow detail visual choroid structur identifi alter may expand comprehens age amd develop | D002829;D008268 | T023;T024;T047 |
36,233,310 | short promot region contain conserv regulatori motif requir steroidogen acut regulatori protein star gene express mous testi testi leydig cell produc steroid hormon need masculin typic genet male fetal develop initi maintain spermatogenesi puberti adulthood respect steroidogenesi initi transfer cholesterol outer inner mitochondri membran action steroidogen acut regulatori protein star given import steroidogen process regul star gene express subject numer studi studi involv character key promot sequenc identif relev transcript factor nucleotid motif regulatori element bind work tradit reli vitro studi carri cell cultur along reconstruct promot sequenc approach use develop model gene might transcript regul one must ultim valid mode regul occur endogen context use crisprca genom edit modifi short region mous star promot contain subset regulatori element includ conserv cre cebp ap gata motif propos critic star transcript analysi result mutant mice show short promot region inde requir maxim star mrna protein level testi analysi also show basal hormon activ testosteron product matur mice unaffect despit signific chang star express result therefor provid first vivo valid regulatori sequenc requir star gene express | D010750;D011401;D012741;D013737 | T023;T116;T123;T040;T114 |
36,233,309 | ngatha like gene dpa sod requir stem cell specif embryo develop arabidopsi thaliana plant stem cell embed structur call meristem meristem form either embryogenesi plant life instanc axillari meristem regul stem cell popul establish meristem well describ initi newli form meristem less well understood recent two transcript factor ngatha like famili develop relat pcg target apex dpa ngal suppressor da sod ngal shown facilit de novo stem cell initi arabidopsi thaliana axillari meristem test whether dpa sod gene similar role stem cell format embryo shoot apic meristem use dpa sod report line character express pattern gene embryo develop reveal partial overlap stem cell popul addit show express stem cell report modifi dpa sod doubl mutant embryo compar wild type togeth observ suggest dpa sod requir stem cell specif embryo shoot apic meristem initi work stress differ regulatori network lead meristem format embryon post embryon phase | D017360;D029681 | T116;T002 |
36,233,308 | oocyt specif knockout histon lysin demethylas kdma compromis fertil block develop follicl oocyt methyl status histon play crucial role mani cellular process includ follicular oocyt develop lysin specif demethylas kdma report close associ gametogenesi reproduct perform specif function regulatori mechan poor character vivo found kdma high express grow follicl oocyt mice studi elucid physiolog role kdma zona pellucida cre zp cre loxp system use generat oocyt kdma condit knockout zp cre kdmafloxflox term kdma cko model result show number pup reduc approxim adult kdma cko femal mice mate wildtyp male control kdmafloxflox group analyz potenti caus ovari kdma cko mice subject histolog examin result indic obvious differ follicular develop kdma cko control femal mice partial arrest primari antral follicl stage gvbd matur rate oocyt also compromis condit knockout kdma morpholog abnorm oocyt increas furthermor level estradiol kdma cko mice counterpart hormon sensit decreas total number ovul matur oocyt decreas superovul delet kdma pattern hkme gvbd stage oocyt remark chang transcriptom sequenc show mrna express profil kdma cko oocyt signific differ numer differenti express gene involv pathway regul follicular oocyt develop taken togeth result indic oocyt specif knockout kdma gene led femal subfertil suggest crucial role kdma epigenet modif follicular oocyt develop | D006657;D056484 | T126;T123;T116 |
36,233,307 | bioactiv phytochem salix pseudolasiogyn twig anti adipogen effect acetylsalicortin l cell salix pseudolasiogyn salicacea willow tree use medicin herb korea treat pain fever part ongo studi identifi bioactiv natur product potenti anti adipogen compound investig use ethanol etoh extract pseudolasiogyn twig phytochem investig etoh extract use liquid chromatographi mass spectrometri lcms led separ two compound oregonin acetylsalicortin structur isol identifi use nuclear magnet reson spectroscopi lcms analysi best knowledg first report identifi oregonin twig pseudolasiogyn found isol compound oregonin acetylsalicortin show anti adipogen effect l cell differenti notabl acetylsalicortin concentr signific suppress lipid accumul moreov mrna protein level lipogen adipogen transcript factor reduc acetylsalicortin treat l cell taken togeth result indic acetylsalicortin isol pseudolasiogyn twig potenti appli therapeut agent effect control adipocyt differenti critic stage progress obes | D032108 | T002 |
36,233,306 | wrki transcript factor oswrki involv salt toler rice salt stress critic limit factor rice growth product although numer salt toler gene identifi mechan under salt stress toler rice remain unclear studi report need uncharacter wrki transcript factor oswrki rice salt toler salt stress result rapid induct oswrki express root immunostain analysi show main express stele loss oswrki result greater na accumul shoot enhanc sensit rice plant salt stress real time quantit pcr qrt pcr transcriptom analysi reveal oswrki regul express essenti gene relat salt toler osnhx oshkt furthermor oswrki found regul oshkt express direct bind w box motif promot thus result indic oswrki critic regulatori factor salt toler rice | D012275;D055049 | T168;T040;T002 |
36,233,305 | dpagt missens variant caus degen retinopathi without myasthen syndrom mice congenit disord glycosyl cdg heterogen group primarili autosom recess mendelian diseas caus disrupt synthesi lipid link oligosaccharid transfer protein cdgs usual affect multipl organ system vari present even within famili current cure treatment aim amelior symptom improv qualiti life describ chemic induc mous mutant tvrm earli onset photoreceptor degener recess mutat map chromosom associ missens mutat dpagt gene encod udp n acetyl glucosamin dolichyl phosphat n acetyl glucosaminephosphotransferas ec mutat predict caus substitut aspart acid glycin residu dpagt repres first viabl anim model dpagt mutat novel phenotyp cdg increas express ddit elev level hspa bip suggest presenc earli onset endoplasm reticulum er stress chang associ induct photoreceptor apoptosi tvrm retina mutat human dpagt caus myasthen syndrom sever form congenit disord glycosyl type ij contrast dpagttvrm homozyg mice present congenit photoreceptor degener without overt muscl muscular junction involv result suggest possibl dpagt mutat human patient present primarili retin pigmentosa littl muscl diseas variant dpagt consid evalu case non syndrom retin degener | D018981;D012164 | T047 |
36,233,304 | advanc fungal elicitor trigger plant immun array pathogen fungi natur environ plant produc molecul includ pathogen associ molecular pattern pamp effector infect molecul recogn plant specif receptor activ plant immun includ pti pamp trigger immun eti effector trigger immun call elicitor undoubt identif novel fungal elicitor plant receptor comprehens understand fungal elicitor trigger plant immun great signific effect control plant diseas great progress occur fungal elicitor trigger plant immun especi signal pathway pti eti recent year recent advanc fungal elicitor trigger plant immun summar import contribut enlighten plant diseas control also discuss | D000069452;D057865 | T085;T123;T039 |
36,233,303 | saposin c key regul alpha synuclein degrad mediat lysosom lysosom dysfunct propos one import pathogen molecular mechan parkinson diseas pd signific evid lie gba gene encod lysosom enzym glucocerebrosidas gcase consid main genet risk factor sporad pd loss gcase activ result format synuclein deposit present studi aim determin activ main lysosom enzym cofactor prosaposin psap saposin c pd healthi control contribut synuclein syn aggreg pd patient age match healthi control includ studi first analyz gcase galactosidas gal hexosaminidas hex b cathepsin catd activ white blood cell also measur gba gal hex ctsd psap saposin c syn protein level western blot found reduc gcase gal activ pd patient compar control psap saposin c protein level signific lower pd patient correl increas level synuclein catd contrast show signific increas activ protein level pd patient compar control increas ctsd protein level pd patient correl intrigu higher concentr syn find suggest lysosom dysfunct sporad pd due least part alter saposin c deriv reduc psap level would lead signific decreas gcase activ result accumul syn accumul monohexosylceramid might act favor ctsd activ therefor increas enzymat activ evalu lysosom activ peripher blood patient expect promis approach investig patholog mechan novel therapi aim restor lysosom function sporad pd | D010300;D051844 | T047;T123;T116 |
36,233,302 | cadmium zinc interact mus musculus fibroblast work aim evalu effect zinc zn relat cadmium cd induc toxic role play mtf transcript factor regul express gene encod metallothionein mts zn transport heavi chain glutamylcystein synthetas reason two cell line mous fibroblast use wild type strain knockout strain studi effect cell expos complet medium contain znso zn cdcl cd cdcl cd znso cdcl zncd znso cdcl zncd h follow exposur cell viabil intracellular content metal glutathion gsh mt gene express two isoform mt evalu result obtain suggest lower cd content co treatment respons protect offer zn due probabl competit common transport furthermor zn determin increas gsh co treatment compar treatment cd alon final mtf factor essenti express mt mt probabl heavi chain glutamylcystein synthetas | D002104;D002105 | T131;T196;T037 |
36,233,301 | calcium bound sp protein promiscu bind partner four helic cytokin protein multifunct calcium bind protein vertebr act intracellular extracellular engag progress mani social signific diseas extracellular action typic mediat recognit specif receptor protein recent studi indic abil protein affect cytokin signal direct interact cytokin sp shown protein activ involv interact four helic cytokin assess select sp protein bind four helic cytokin probe interact ca bound recombin human sp panel four helic human cytokin cover structur famili fold use surfac plasmon reson spectroscopi total cytokin famili four helic cytokin sp binder equilibrium dissoci constant kd rang nm kd valu sp complex v domain convent receptor receptor advanc glycat end product rage molecular dock mutagenesi studi reveal presenc sp molecul cytokin bind site overlap rage bind site sinc bind four helic cytokin inhibit signal case reveal abil sp protein interact ca four helic cytokin indic sp may serv poor select inhibitor action | D002118;D002135;D016207 | T116;T192;T121;T123;T196;T129 |
36,233,300 | synovi extracellular vesicl structur role synovi fluid tribolog perform qualiti lubric cartilagin joint surfac impact joint mechanist properti studi defin biochem ultrastructur tribolog signatur synovi fluid sf patient degen osteoarthr oa inflammatori rheumatoid arthriti ra joint patholog comparison sf healthi subject phospholipid pl concentr sf increas patholog context proport pl relat overal lipid decreas subtl chang pl chain composit attribut inflammatori state transmiss electron microscopi show occurr larg multilamellar synovi extracellular vesicl ev fill glycoprotein gel healthi subject synovi extracellular vesicl structur alter sf oa ra patient ra sampl systemat show lower viscos healthi sampl hydrodynam lubric regimen wherea oa sampl show higher viscos turn boundari regimen cartilag surfac patholog situat show high wear friction coeffici thus found differ biochem tribolog ultrastructur properti synovi fluid healthi peopl patient osteoarthr arthriti joint larg multilamellar vesicl essenti good boundari lubric ensur ball bear effect limit destruct lipid layer cartilag surfac | D002358;D000067128;D010003 | T026;T024;T047 |
36,233,299 | bioinformat assess factor affect correl protein abund elong effici prokaryot protein abund crucial major genet regul cell function act proper prokaryot organ therefor develop bioinformat method assess effici differ stage gene express great import predict actual protein abund one step evalu translat elong effici base mrna sequenc featur codon usag bias mrna secondari structur properti studi evalu correl coeffici experiment measur protein abund predict elong effici characterist prokaryot includ non model organ belong divers taxonom group algorithm assess elong effici take account codon bias also number energi secondari structur mrna demonstr impact predict elong effici ribosom protein gene result show number organ secondari structur better predictor protein abund codon usag bias bioinformat analysi reveal sever factor associ valu correl coeffici first factor elong effici optim type organ whose genom optim codon usag signific higher correl coeffici second factor taxonom ident bacteria belong class bacilli tend higher correl coeffici among analyz set third growth rate shown higher organ higher correl coeffici protein abund predict translat elong effici obtain result use improv method protein abund predict | D019295;D014176 | T091;T044 |
36,233,298 | plasma campesterol posit associ carotid plaqu asymptomat subject increas cholesterol absorpt reduc synthesi process associ cardiovascular diseas risk controversi way howev studi involv marker cholesterol synthesi absorpt includ condit obes diabet dyslipidemia confound factor present studi aim investig relationship plasma cholesterol synthesi absorpt marker cardiovascular diseas cvd risk factor cimt carotid intima media thick presenc carotid plaqu asymptomat subject | D002318;D010840;D058226 | T047;T046;T020;T121;T109;T123;T031 |
36,233,297 | portabl plasmon paper base biosensor simpl rapid indirect detect ceacam biomark via metal enhanc fluoresc rapid simpl sensit analysi relev protein crucial mani research area clinic diagnosi biomark detect particular clinic data cancer biomark show great promis form reliabl predict earli cancer diagnost although current analyt system difficult implement region limit recours paper base biosensor particular recent receiv great interest meet criteria point care poc devic main drawback devic low sensit effici perform quantit measur work design low cost paper base nanosensor plasmon calligraphi direct draw individu plasmon line filter paper use ballpoint pen fill gold nanorod aunr colloid ink plasmon array success coat negat posit charg polyelectrolyt layer employ dielectr spacer promot enhanc emiss carboxyl function quantum dot qd previous conjug specif antibodi indirect detect carcinoembryon antigen relat cell adhes molecul ceacam effici sensit well specif portabl nanosensor valid record luminesc qd ab complex differ concentr ceacam ad dropwis onto calligraph plasmon array | D015374;D043942 | T059;T075;T073 |
36,233,296 | divers role conserv dna methyltransferas entomopathogen bacterium xenorhabdus bacteria dna methyltransferas respons dna methyl specif motif genom methyl usual occur high rate present studi studi mtase encod gene found entomopathogen bacteria xenorhabdus one persist mtase identifi various speci genus mtase also broad conserv numer gram negat bacteria call dam dna adenin mtase methylom analysi confirm gatc motif recogn dam methyl rate gt studi strain observ enrich unmethyl motif putat promot region x nematophila f strain suggest possibl epigenet regul overexpress dam mtase respons addit motif methyl associ impair two major phenotyp motil caus downregul flagellar gene hemolysi howev result suggest dam overexpress modifi virul properti x nematophila studi increas knowledg divers role play mtase bacteria | D015265;D020593 | T007;T126;T116 |
36,233,295 | nemalin myopathi brazilian patient molecular clinic character nemalin myopathi nm structur congenit myopathi present signific clinic genet heterogen compil molecular clinic data brazilian patient unrel famili next generat sequenc abl genet classifi patient sixteen famili mutat neb five acta two klhl one tpm tpm neb relat famili differ variant novel identifi splice site frame shift mutat common mutat c g gt c recurr three unrel patient region suggest common ancestor clinic typic form frequent caus mutat differ nm gene phenotyp heterogen observ among patient mutat gene respiratori involv common often proport limb weak muscl mri pattern show variabl within form gene relat sever weak consid high frequenc neb mutat complex gene ngs tool combin cnv identif especi patient like non identifi second mutat | D017696;D009224 | T047 |
36,233,294 | bioinformat experiment analys reveal immun relat lncrna mrna pair ac ccr biomark therapeut target ischem cardiomyopathi ischem cardiomyopathi icm increas along age lead caus heart failur current immun respons believ critic icm wherea role immun relat lncrnas remain vagu studi aim systemat analyz immun relat lncrnas age relat diseas icm download public avail rna seq data ischem cardiomyopathi patient non fail control gse weight gene co express network analysi wgcna perform identifi key icm relat modul immun relat lncrnas key modul screen co express analysi immun relat mrnas compet endogen rna cerna network includ lncrnas mrnas construct use lncrna mrna pair share regulatori mirna signific correl among lncrna mrna pair one pair ac ccr verifi anoth public avail icm dataset gse ischem cell model immun cell infiltr analysi gse dataset reveal proport monocyt cd cell negat correl express ac ccr plasma cell posit correl indic ac ccr may particip occurr develop icm immun cell infiltr togeth find reveal lncrna mrna pair ac ccr may novel biomark therapeut target icm | D009202;D035683;D062085 | T047;T123;T114 |
36,233,293 | interact mrpl ggct promot cell prolifer migrat activ mapkerk pathway papillari thyroid cancer thyroid cancer remain common endocrin malign worldwid incid steadili increas past four year papillari thyroid cancer ptc common differenti thyroid cancer account thyroid cancer mitochondri protein mrps import part structur function integr mitochondri ribosom complex report mrpl high express liver cancer promot cell prolifer migrat report ptc present studi found mrpl high express ptc tissu cell line lentivirus mediat overexpress mrpl promot prolifer migrat abil ptc cell wherea knockdown mrpl opposit effect interact mrpl ggct glutamylcyclotransferas found immunofluoresc co immunoprecipit experi co ip addit ggct high express ptc tissu cell line knockdown ggctmrpl vivo inhibit growth subcutan xenograft nude mice inhibit format lung metastas mechanist found knockdown ggctmrpl inhibit mapkerk signal pathway conclus studi found interact ggct mrpl modul mapkerk pathway affect prolifer migrat ptc cell therefor ggctmrpl may serv potenti biomark ptc monitor ptc treatment | D020935;D013964;D005722 | T191;T044;T126;T116 |
36,233,292 | clone maiz ted transposon escherichia coli reveal polychromat sequenc landscap refractorili propag plasmid mudr founder member mutat superfamili mura transcript identifi toxic sequenc escherichia coli e coli heavili hinder elucid biochem featur mura transposas confin broader applic mutat system organ har less constrain system altern attempt clone ted jitteri two recent isol autonom mutat like element mule maiz respect full length transcript genom copi success clone incub time bacteria recov heat shock extend appropri prior plate howev prolifer e coli ted transform plasmid unstabl evidenc deriv frameshift delet mutat transposon insert readili detect result suggest neither leaki express transposas presenc termin invers repeat tir respons clone barrier ascrib presenc shine dalgarno like sequenc instead intern sequenc ted bp especi exon region like causer find provid novel insight properti function mutat superfamili shed light dissect toxic effect clone mule | D004926;D003313 | T007;T168;T002 |
36,233,291 | multifunct interleukin resolv neuroretina autoimmun via divers mechan il multifunct cytokin regul immun cell epitheli cell although elev associ number autoimmun diseas tolerogen properti autoreact cell recent reveal anim model central nervous system cns autoimmun inhibit pathogen th respons explor potenti il therapeut agent cns autoimmun induc experiment autoimmun uveiti eau wildtyp mice intravitr inject il inflam eye diseas onset found progress ocular inflamm signific inhibit il treat eye compar control eye import il treatment suppress cytokin product ocular infiltr pathogen th th cell vitro experi confirm il suppress th th differenti regul master transcript factor bet rort respect addit found intravitr inject il suppress product proinflammatori cytokin chemokin retina eau inflam eye observ appear applic human il similar inhibit human retin pigment epithelium cell arp conclus report il multifunct cytokin capabl resolv ocular inflamm eau mice target uveitogen cell rpe cell studi shed new light il potenti therapeut candid autoimmun uveiti | D001327;D014605 | T047 |
36,233,290 | singl oral vitamin bolus reduc inflammatori marker healthi saudi male vitamin defici increas general popul public health issu vitamin play import role regul immun system eg modul product inflammatori cytokin countri recommend maxim daili dose vitamin iu g per day studi investig whether singl vitamin bolus reduc level inflammatori marker interleukin il il tumor necrosi factor tnf within one month fifti healthi saudi male recruit local communiti jeddah citi oral supplement singl dose iu vitamin serum sampl collect time point day serum level il il tnf parathyroid hormon pth hydroxyvitamin oh triglycerid cholesterol calcium ca phosphat po determin averag vitamin bolus result signific increas vitamin status well signific decreas level inflammatori cytokin even one month supplement without chang serum ca po lipid level conclus singl high dose vitamin supplement safe reduc inflamm marker may lead updat current recommend vitamin intak order prevent critic health problem | D002762;D014808 | T121;T047;T109;T127 |
36,233,289 | gut microbiota therapi metastat melanoma focus mapk pathway inhibit gut microbiom gm either pro tumorigen anti tumorigen role intrigu constitut evolv landscap translat oncolog suggest microorgan may involv carcinogenesi cancer treatment respons resist well predisposit advers effect melanoma patient one immunogen cancer immun checkpoint inhibitor ici mapk target therapi brafmek inhibitor revolution prognosi studi microbiom modul factor thus appeal although brafmek inhibitor constitut one main backbon treatment melanoma littl known impact gm might correl immun induct contrari ici relationship gm becom interest field research due alreadi known impact immunotherapi modul immun system immun reprogram tumor microenviron establish one main target microbiom sinc induc immunosuppress phenotyp promot inflammatori respons conduct anti tumor respons result ongo clinic trial evalu role fecal microbiota transplant fmt well impact use dietari supplement antibiot probiot predict respons therapi review provid overview gm link cancer relationship immun system may impact respons treatment melanoma patient also discuss insight novel therapeut approach includ fmt chang diet use probiot prebiot symbiot final hypothes possibl pathway gm may impact anti tumor efficaci melanoma patient treat target therapi appeal subject littl known | D000069196;D008545;D016609 | T007;T001;T191 |
36,233,288 | benefit sodium glucos co transport inhibit heart failur role kidney essenti homeostat role kidney two intraren mechan promin glomerulotubular balanc drive process na water reabsorpt proxim tubul tubuloglomerular feedback sens na concentr filtrat juxtaglomerular apparatus provid negat feedback glomerular filtrat rate essenc two mechan regul renal oxygen consumpt renal hyperfiltr driven increas glomerular filtrat pressur glucos diuresi affect renal consumpt unleash detriment sympathet activ sodium glucos co transport inhibitor sglti rebal reabsorpt na coupl glucos restor renal demand diminish neuroendocrin activ larg random control studi perform diabet subject heart failur popul chronic kidney diseas without diabet concord address effect action heart failur exacerb renal advers outcom | D003920;D003928;D006333;D000077203 | T121;T047;T046;T109 |
36,233,287 | mot c recent mitochondri deriv peptid human age age relat diseas mot c amino acid mitochondri deriv peptid encod rrna region mitochondri genom stress condit mot c transloc nucleus regul wide rang gene respons metabol dysfunct coloc mitochondria various tissu found plasma level declin age sinc mot c import cellular function well possibl hormon role shown benefici effect age relat diseas includ diabet cardiovascular diseas osteoporosi postmenopaus obes alzheim age character gradual loss mitochondri metabol balanc decreas muscl homeostasi eventu diminish physic capabl potenti revers mot c treatment review examin latest find biolog effect mot c nuclear regulatori peptid focus role mot c age age relat disord includ mechan action therapeut potenti | D008928;D024101 | T043;T026;T123;T116 |
36,233,286 | molecular character vitellogenin receptor spodoptera frugiperda j e smith function reproduct femal fall armyworm spodoptera frugiperda high polyphag invas pest strong reproduct capac import factor rapid colon expans frugiperda vitellogenin vg vitellogenin receptor vgr play import role insect reproduct precursor vitellin vn vg provid essenti nutrit embryon develop vgr mediat uptak vg oocyt context clone character two gene frugiperda sfvg sfvgr evalu express profil differ development stage tissu rna interfer experi use investig function vitellogenesi orf valu sfvg sfvgr bp encod amino acid residu respect qrt pcr result reveal sfvg sfvgr high express femal adult sfvg specif express fat bodi wherea sfvgr high express ovari addit deplet either sfvg sfvgr hinder oocyt matur ovarian develop lead signific decreas fecund present studi reveal import sfvg sfvgr vitellogenesi frugiperda lay theoret foundat develop pollut free pest control strategi sfvg sfvgr new target | D014818;D014819 | T042;T123;T116 |
36,233,285 | predict recurr gastric cancer use textur featur perigastr adipos tissu f fdg petct studi aim assess relationship histopatholog textur featur perigastr adipos tissu deoxi f fluoro glucos f fdg positron emiss tomographycomput tomographi petct evalu prognost signific perigastr textur featur predict recurr free surviv rfs patient gastric cancer sixti nine patient gastric cancer underw stage f fdg petct subsequ curat surgeri retrospect review textur featur perigastr extract pet imag histopatholog analysi cd cd cd cell infiltr matrix metalloproteinas interleukin il express perigastr grade degre cd cell infiltr perigastr signific correl mean standard uptak valu suv suv histogram entropi grey level co occurr matrix glcm energi glcm entropi perigastr degre il express perigastr signific correl mean median suv perigastr multivari surviv analysi glcm entropi glcm dissimilar glcm homogen perigastr signific predictor rfs textur featur perigastr f fdg petct signific correl inflammatori respons perigastr signific prognost factor predict rfs patient gastric cancer | D019788;D013274 | T191;T109;T130 |
36,233,284 | contract band necrosi dephosphoryl connexin rat myocardium daili cocain administr contract band necrosi cbn common abnorm found myocardium cocain abus rare report experiment model cocain abus connexin cx essenti cardiac intercellular communic propag cbn stress injuri cardiac cx dephosphoryl relat cardiomyocyt dysfunct pathogenesi wherea adiponectin exert benefici effect myocardium studi explor effect cocain cardiac cx vivo rat administ cocain via tail vein mgkgday day show widespread cbn microfoc myocard myocardi fibrosi correspond dysfunct cardiac mitochondria increas oxid stress increas dephosphoryl cardiac cx negat correl myocardi distribut cbn cocain administr determin addit apoptosi necroptosi well increas adiponectin level observ myocardium cocain exposur accord found alter profil cardiac cx cbn negat correl dephosphoryl cardiac cx possibl involv adiponectin myocardium day cocain administr latter might play protect role cardiotox cocain current find would benefici establish novel therapeut strategi cocain induc cardiac consequ | D003042;D018031 | T116;T131;T121;T109;T123 |
36,233,283 | select ligand non canon dna structur futur medicin chemistri win war cancer repres major goal current | D002626;D009369 | T191;T091 |
36,233,282 | cytokin immun cell profil differ tissu rodent induc environment enrich systemat review environment enrich ee base promot socio environment stimuli mimic favor environment condit practic physic activ health object present systemat review evalu influenc ee pro anti inflammatori immun paramet also cell activ relat innat acquir immun respons brain peripher tissu rodent three databas pubm articl scopus articl scienc direct articl research appli elig criteria articl select peer review independ identifi septemb protocol systemat review regist prospero articl found select systemat review brain ee promot reduct proinflammatori cytokin chemokin blood ee promot higher percentag leukocyt increas cd b lymphocyt prolifer natura killer nk cell bone marrow increas number cd cdb matur nk cell reduct cd cdb immatur natur killer cell conclus ee immun modul approach play key role prevent numer chronic diseas includ cancer pro inflammatori respons immunosuppress condit part pathophysiolog | D016207;D012377 | T015;T116;T129 |
36,233,281 | novel detect method breast cancer simpl panel biomark circul tumor cell ctcs identifi respons spread tumor organ bodi sens develop sensit specif assay detect import reduc number death due metastas assess whether detect ctcs peripher blood serv construct panel diagnosi monitor treatment breast cancer bc focus express marker epitheli mesenchym transit analyz blood women without breast alter control women benign alter women breast cancer without chemotherapi women breast cancer chemotherapi identifi best marker transcript level determin three profil ctcs mesenchym intermedi epitheli flow cytometri combin use diagnosi therapi monitor sensit specif therefor develop method detect breast cancer base analysi ctc profil epitheli mesenchym transit marker combin use diagnosi monitor therapi | D001943;D009360 | T191;T025 |
36,233,280 | resveratrol improv digest abil intestin health siberian sturgeon lack detail inform nutrit requir result limit feed siberian sturgeon studi resveratrol versatil natur extract supplement daili diet digest abil microbiom evalu duodena valvular intestin siberian sturgeon result show resveratrol increas activ pepsin amylas lipas posit associ increas digest abil influenc final bodi weight resveratrol improv digest abil probabl distinct enhanc intestin villus height microbiom analysi reveal resveratrol chang abund composit microbi communiti intestin princip duodenum random forest analysi found resveratrol signific downregul abund potenti pathogen citrobact freundii vibrio rumoiensi brucella melitensi suggest resveratrol may also improv intestin health summari studi reveal resveratrol improv digest abil intestin health contribut develop function feed siberian sturgeon | D000821;D010434 | T126;T168;T116;T121 |
36,233,279 | tomato microrna function microrna mirna defin essenti class non code small rnas function posttranscript modul gene express code mir gene sever hundr exist genom arabidopsi rice model plant function analysi arabidopsi rice mirna indic mirna regul wide rang process includ develop reproduct metabol stress tomato serv major model crop studi fleshi fruit develop ripen recent inform ident mir gene code mirna limit occasion contradictori result major tomato mirna remain uncharacter recent comprehens annot tomato mir gene carri sever lab us review curat organ result partial overlap mir annot exhaust non redund atlas tomato mir gene candid valid mir gene atlas code high conserv solanacea specif tomato specif mirna respect furthermor critic review function studi tomato mirna present highlight valid possibl function creat use resourc futur tomato mirna research | D017360;D018551;D035683;D012275 | T123;T168;T002;T114 |
36,233,278 | comparison flavonoid biosynthesi mechan dendrobium speci analyz transcriptom metabolom dendrobium huoshanens dendrobium officinal dendrobium moniliform precious chines medicin materi varieti medicin properti flavonoid import medicin compon dendrobium accumul rule biosynthesi mechan remain unclear explor similar differ flavonoid accumul biosynthesi three dendrobium speci perform flavonoid content determin wide target metabolom transcriptom sequenc year old dendrobium speci result show differ growth year huoshanens stem highest flavonoid content second year growth officinal moniliform stem highest flavonoid content third year growth total differenti accumul metabolit dam differenti express gene deg identifi metabolom transcriptom analysi found dam deg enrich general pathway flavonoid biosynthesi also multipl sub pathway flavon biosynthesi flavonol biosynthesi isoflavonoid biosynthesi accord combin transcriptom metabolom analysi express level f h gene loc two f h gene loc loc may main gene respons differ flavonoid accumul result studi determin optim harvest period three dendrobium plant also identifi key gene involv flavonoid biosynthesi provid basi studi molecular mechan flavonoid synthesi | D031667;D047309 | T109;T002 |
36,233,277 | mir target squamosa promot bind protein pmsbp transcript factor regul flower time bind promot suppressor overexpress co pmsoc prunus mume prunus mume famous perenni ornament plant fruit tree asia bloom winter earli spring yangtz river area flower time direct determin ornament econom valu great signific studi molecular mechan flower time squamosa promot bind protein sbp often regul mir import flower regul although function unknown p mume mir precursor analyz locat five chromosom p mume genom express pattern show pmsbp negat correl mir promot pmsbp specif express apic meristem overexpress pmsbp tobacco promot flower chang length ratio pistil stamen moreov pmsbp also affect number vital pollen reduc fertil transgen tobacco furthermor ectop express pmsbp caus regul express endogen suppressor overexpress co ntsoc yeast one hybrid assay show pmsbp bond promot pmsoc conclus mir pmsbp pmsoc pathway form particip regul flower time p mume provid refer molecular mechan flower time regul molecular breed p mume | D035683;D027861 | T123;T002;T114 |
36,233,276 | multi omic analysi reveal signific alter critic metabol pathway due sorafenib resist hepb cell line hepatocellular carcinoma hcc second promin caus cancer associ death worldwid usual hcc diagnos advanc stage wherein sorafenib multipl target tyrosin kinas inhibitor use first line treatment unfortun resist sorafenib usual encount within six month treatment therefor critic need identifi under reason drug resist present studi investig proteom metabolom alter accompani sorafenib resist hepatocellular carcinoma hepb cell employ ultra high perform liquid chromatographi quadrupol time flight mass spectrometri uhplc qtof ms bruker human metabolom databas hmdb librari use identifi differenti abund metabolit metaboscap softwar bruker protein annot identif uniprot proteom homo sapien human databas util maxquant result reveal metabolit protein signific dysregul due sorafenib resist hepb cell compar parent phenotyp alanin l prolin tyrosin succin acid phosphatidylcholin pc among signific alter metabolit ubiquitin carboxyl termin hydrolas isozym l mitochondri superoxid dismutas udp glucos dehydrogenas sorbitol dehydrogenas calpain small subunit among signific alter protein find reveal resist hepb cell demonstr signific alter amino acid nucleotid metabol pathway energi product pathway pathway relat cancer aggress migrat prolifer drug resist joint pathway enrich analysi unveil uniqu pathway includ antifol resist pathway import pathway maintain cancer cell surviv growth prolifer collect result identifi potenti biomark sorafenib resist hcc gave insight role chemotherapeut drug resist cancer initi progress aggress may contribut better prognosi chemotherapeut outcom | D000970;D006528;D005493;D008113 | T121;T109;T191 |
36,233,275 | synerg effect earli administr probiot adipos deriv mesenchym stem cell allevi inflamm induc chronic neuropath pain rodent studi investig hypothesi probiot enhanc therapeut effect adipos deriv mesenchym stem cell admsc allevi neuropath pain np due chronic constrict injuri cci main regul microbiota rat sd rat n categor group sham control group np group np probiot ie billion cfudayrat oral h np procedur follow qod time group np admsc cell h cci procedur follow qod six time ie seven time total ie mimic clinic set drug use group np probiot admsc cell euthan day np induct day np induct flow cytometr analysi show circul level earli v pi late v pi apoptot three inflammatori cdb c lyg mpo cell lowest group signific progress reduc group p lt day cci threshold thermal paw withdraw latenc pwl mechan paw withdraw threshold pwt highest group signific progress increas group p lt number pain conniv cell navperipherin p erkperipherin p pperipherin p pnf protein express inflammatori p nf b il tnf mmp apoptot cleav caspas cleav parp oxid stress nox nox dna damag hax mapk famili p p p jnk p erk biomark well protein level nav nav nav l l dorsal root ganglia display opposit pattern mechan pwt among group p lt conclus combin probiot admsc therapi superior mere one allevi cci induc np main suppress inflamm oxid stress | D059630;D009437;D019936 | T007;T025;T184;T047 |
36,233,274 | rsttg wd protein interact bhlh transcript factor rstt regul anthocyanin proanthocyanidin biosynthesi raphanus sativus mbw complex consist myb basic helix loop helix bhlh wd protein regul multipl trait plant includ anthocyanin proanthocyanidin pa biosynthesi determin epiderm cell fate wd gene raphanus sativus design transpar testa glabra rsttg clone function character heterolog express rsttg arabidopsi thaliana mutant ttg background restor accumul anthocyanin pa mutant rescu trichom develop radish rsttg abund express root leaf tissu independ anthocyanin accumul mbw partner rsmyb transpar testa rstt express higher level pigment accumul tissu yeast two hybrid analysi full length rsttg protein interact rstt moreov transient protoplast co express assay demonstr rsttg local cytoplasm nucleus move cytoplasm nucleus presenc rstt co express rsmyb rstt rsttg stabli activ promot anthocyanin biosynthesi gene chalcon synthas rschs dihydroflavonol reductas rsdfr transient express rsttg tobacco leav exhibit increas anthocyanin accumul due activ express anthocyanin biosynthesi gene simultan express rsmyb rstt result indic rsttg vital regul pigment trichom develop function homolog atttg | D017360;D044945;D031224 | T121;T109;T002 |
36,233,273 | develop hallmark pathway relat gene signatur associ immun respons lower grade glioma although biomark use predict prognosi lower grade glioma lggs pathway relat signatur associ immun respons develop key signal pathway determin accord lowest adjust p valu among hallmark pathway least absolut shrinkag select oper lasso stepwis multivari cox analys perform construct pathway relat gene signatur somat mutat drug sensit predict immunotherapi analys conduct reveal valu signatur target therapi studi allograft reject ar pathway consid crucial signal pathway construct ar relat five gene signatur independ predict prognosi lggs high ar lgg patient higher tumor mutat burden tmb immunophenscor ip immuno predict score impr cell inflam gene express profil gep score mhc associ immunoscor mia low ar patient import signatur valid four immunotherapi cohort furthermor ic valu six classic chemotherapeut drug signific elev low ar group compar high ar group signatur might regard under biomark predict prognosi lggs possibl provid therapeut strategi futur clinic research | D015972;D005910 | T191;T045 |
36,233,272 | gene network involv plant heat stress respons toler global warm environment problem ignor high temperatur serious affect normal growth develop plant threaten develop agricultur distribut surviv speci risk plant evolv complex effici mechan sens respond high temperatur involv activ numer function protein regulatori protein non code rnas mechan consist larg regulatori network regul protein rna structur stabil induc ca hormon signal transduct mediat sucros water transport activ antioxid defens maintain normal metabol pathway articl review recent research result molecular mechan plant respons high temperatur highlight futur direct strategi promot plant heat toler therebi help identifi regulatori mechan heat stress respons plant | D053263;D010940 | T044;T116 |
36,233,271 | facilit insulin effect ranolazin astrocyt primari cultur ranolazin rn drug use treat persist chronic coronari ischemia also shown therapeut benefit central nervous system anti diabet effect lower blood glucos level howev effect rn cellular sensit insulin in demonstr yet present studi aim investig permiss effect rn action in astrocyt primari cultur in rn in rn respect ad astrocyt h comparison control cell rn andor in caus modif cell viabil prolifer rn increas protein express cuzn sod pro inflammatori protein cox upregul in contrari signific chang found protein express nf b ib presenc rn produc increas p erk protein signific decreas cox protein express furthermor rn signific increas effect in express p akt p eno p erk mn sod ppar addit rn in produc signific decreas cox express conclus rn facilit effect insulin p akt p eno p erk mn sod ppar signal pathway well anti inflammatori antioxid effect hormon | D001253;D007328 | T121;T025;T116;T125 |
36,233,270 | genom wide predict analysi oryza speci nrp gene rice blast resist member n rich protein nrps gene famili play import role plant endoplasm reticulum stress respons trigger plant pathogen infect previous studi nrp gene famili limit plant soybean arabidopsi thaliana thus evolutionari characterist oryza speci biolog function rice defens pathogen fungus magnaporth oryza remain unexplor present studi demonstr nrp gene famili may origin earli stage plant evolut strong conserv evolut oryza speci domain organ nrps found high conserv within subgroup osnrp nrp gene oryza sativa japonica group specif regul earli stage rice oryza interact inhibit oryza infect predict protein protein interact network transcript factor bind site reveal candid interactor bzip may involv osnrp mediat rice resist oryza infect taken togeth result establish basi futur studi nrp gene famili provid molecular insight rice immun respons oryza | D017360;D020082;D012275 | T168;T004;T002 |
36,233,269 | molecular mechan target therapi advanc basal cell carcinoma among human cutan malign basal cell carcinoma common solid advanc unveil molecular mechan basal cell carcinoma emerg recent year gorlin syndrom show basal cell carcinoma predisposit identif patch gene ptch mutat dramat breakthrough understand carcinogenesi basal cell carcinoma ptch play role hedgehog pathway dysregul pathway known crucial carcinogenesi mani type cancer includ sporad well hereditari basal cell carcinoma review summar clinic featur patholog featur hedgehog pathway appli basal cell carcinoma crucial molecul p melanocortin receptor also discuss due recent advanc therapeut strategi base precis molecular mechan basal cell carcinoma emerg target therapi biomark also discuss | D002280;D018295;D012878 | T191 |
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