PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
|---|---|---|---|
36,233,168 | bio nanohybrid gelatinquantum dot cellular imag biosens applic bio nanohybrid gelatin proteincadmium sulfid gelcd quantum dot qds design via facil one pot strategi amino acid group gelatin chelat cd grow cds qds without agglomer h nmr spectra indic process alter gelatin protein structur conform chemic function prepar gelcd qds character potenti system cellular imag electrochem sensor hydrogen peroxid h detect applic investig obtain result demonstr develop gelcd qds system could offer simpl conveni oper strategi class contrast agent cell label electrochem sensor purpos | D015374;D045663 | T059;T075;T073 |
36,233,167 | conform prefer pyridon adenin dinucleotid molecular dynam simul pyridon adenin dinucleotid ox nad redox inact deriv enzym cofactor substrat nicotinamid adenin dinucleotid nad carbonyl group c c c posit nicotinamid ring aberr cofactor analog accumul cell stress potenti inhibitor enzym use nad h studi conform landscap ox nad solut use molecular dynam simul compar nad nadh ox nad ox nad enhanc propens adopt anti conform pyridon ribos group wherea ox nad exhibit greater syn potenti consequ ox nad ox nad increas prefer fold compact conform wherea ox nad extend ox nad distinct prefer orient pyridon amid group driven intramolecular hydrogen bond steric interact conform prefer compar protein bound nad h result may help identifi enzym target ox nad | D056004;D009243 | T066;T121;T123;T114;T044 |
36,233,166 | mutat mybl gene associ purpl pigment brassica oleracea anthocyanin well known antioxid benefici plant consum dihydroflavonol reductas dfr key gene anthocyanin biosynthesi control multipl transcript factor express enhanc mutat negat regul anthocyanin biosynthesi myeloblastosi famili transcript factor like mybl express profil dfr gene examin purpl green varieti brassica oleracea l brassica napus l brassica juncea l brassica rapa l mybl gene express signific reduc purpl varieti b oleracea green varieti b juncea mybl gene sequenc screen mutat affect pigment express dfr gene cultivar specif general correl anthocyanin content higher purpl plant two singl nucleotid polymorphysm snps found begin dna bind domain mybl gene purpl varieti b oleracea mutat lead amino acid substitut format mononucleotid repeat signific affect rna structur noteworthi mutat found mybl gene green varieti b oleracea studi speci result bring new insight regul anthocyanin biosynthesi genus brassica provid opportun generat new purpl varieti precis mutat introduc via genet engin crisprca | D000872;D001937 | T121;T109;T168;T002 |
36,233,165 | sequenc genom analysi sorghum dna introgress variant line r recipi rice jin hui reveal repetit element variat transfer genom distant speci crop effici way creat new germplasm howev molecular mechan involv unclear studi new rice restor line r heat toler creat introgress genom dna sorghum recipi restor line jin hui assembl rice r jin hui genom perform use pacbio sequenc technolog compar genom analysi coverag statist show repetit sequenc atr candid introgress fragment sorghum dna sequenc similar analysi reveal atr distribut differ copi number telomer posit chromosom r jin hui sever rice varieti indic repetit sequenc sorghum high conserv rice repeat annot graminea indic ribosom dna loci exist atr may caus rearrang chromosom r genom result copi number variat end studi lay foundat elucid molecular mechan under heat toler sorghum dna introgress variant line r great signific guid crop genet breed | D012275;D045868 | T168;T002 |
36,233,164 | bio inorgan layer doubl hydroxid nanohybrid photochemotherapi mini review clay base bio inorgan nanohybrid layer doubl hydroxid ldh extens research various field biomedicin particular drug deliveri bio imag applic recent trend indic two dimension ldh hybrid varieti photo activ biomolecul select achiev anti cancer benefit numer photochemotherapi pct includ phototherm therapi photodynam therapi magnet hyperthermia combin therapi achiev best treatment regimen patient treat either surgeri radiat alon among novel two dimension clay base bio inorgan nanohybrid ldh could enhanc photo stabil drug releas control pct agent would turn improv overal phototherapeut perform review articl highlight recent advanc ldh base two dimension clay bio inorgan nanohybrid aforement applic | D006878;D010778 | T061;T197 |
36,233,163 | aggress women schizophrenia associ lower hdl cholesterol level studi assess associ serum lipid level aggress femal patient schizophrenia studi includ femal patient schizophrenia n particip subdivid two group aggress nonaggress particip group serum lipid cholesterol triglycerid high densiti lipoprotein hdl cholesterol low densiti lipoprotein ldl cholesterol determin clinic part studi includ evalu use psychiatr scale posit negat syndrom scale panss aggress subscal panss scale panss ag overt aggress scale oa signific differ observ hdl cholesterol level aggress subject signific lower valu hdl cholesterol p represent subject low cholesterol valu almost three time higher group subject aggress p compar nonaggress group nomin signific predictor hdl cholesterol nonaggress aggress particip total valu panss score subject aggress suicid signific associ hdl cholesterol level find suggest lower hdl cholesterol signific associ aggress women schizophrenia | D012559 | T048 |
36,233,162 | alter lipid profil liver impair lipophagi non alcohol fatti liver diseas nafld character excess lipid accumul liver various mechan increas uptak fatti acid de novo synthesi contribut develop steatosi progress sever stage furthermor shown impair lipophagi degrad lipid autophag process contribut nafld unbias lipidom analysi mous liver genet model impair lipophagi aim determin result alter lipidom observ chang overlap human diseas overal entir lipid content particular triacylglycerol concentr increas condit impair lipophagi addit detect reduct long chain polyunsatur fatti acid pufa increas ratio n pufa n pufa due deplet n pufa although abund major phospholipid class reduc ratio phosphatidylcholin phosphatidylethanolamin affect conclus studi demonstr impair lipophagi contribut patholog nafld associ alter lipid profil howev lipid pattern appear specif lipophag alter resembl main describ relat fatti liver diseas | D015525;D065626 | T121;T047;T109;T123 |
36,233,161 | mutat gene phenotyp relat movement disord ataxia clinic seri compris patient movement disord mds andor ataxia cerebellar atrophi ca mani show sign neurodegener brain iron accumul nbia ten nbia gene accept although isol case compat abnorm brain iron deposit known patient evalu use standardis clinic assess ataxia mds first nbia gene analys sanger sequenc patient achiev diagnosi includ detect founder mutat pank ptm romani peopl use custom panel movdisord andor exom sequenc case solv great genet heterogen differ mutat gene three patient present brain iron deposit fe sensit mri sequenc mutat fbxo glb kifa suggest nbia like phenotyp eleven patient show earli onset ataxia ca cortic hyperintens caus mutat itpr kifa sptbn plag pmpca prdx novel variant investig structur model luciferas analysi transcriptminigen studi immunofluoresc assay find expand phenotyp genet mds ataxia earli onset ca cortic hyperintens highlight abnorm brain iron accumul earli cerebellar gliosi may resembl nbia phenotyp | D009069;D019636 | T047 |
36,233,160 | design synthesi vitro evalu spirooxindol base phenylsulfonyl moieti candid anti sar cov mer cov implement combin studi search effect anti viral inhibit covid challeng special scientif research communiti work investig anti coronavirus activ spirooxindol base phenylsulfon cycloadduct singl combin protocol newli design anti sar cov therapeut spirooxindol synthes cycloaddit reaction repres effici approach one pot multicompon reaction phenyl vinyl sulfon substitut isatin amin afford high stereoselect anti sar cov therapeut spirooxindol three stereogen center herein newli synthes spirooxindol assess individu high pathogen human coronavirus prove high potent safer interest synergist effect combin potent test spirooxindol result improv antivir activ well better host cell safeti compound repres potent activ mer cov ic valu respect compound c e show equipot activ best ic sar cov valu respect compound k ic valu respect attent orient perform combin protocol anti sar cov best compound differ bind mode accompani differ pharmacophor combin compound k c combin compound k prove activ safer compound k display ic half maxim cytotox concentr cc md simul potenti compound well silico admet properti investig studi highlight potenti drug like properti spirooxindol cocktail anti coronavirus protocol | D000086382;D065207 | T047;T067;T005 |
36,233,159 | ribosom rack regul dendrit arbor repress fmrp activ fmrp rna bind protein repress translat specif mrnas neuron deplet determin exagger translat mrnas lead dendrit axon aberr develop two peculiar featur fragil x syndrom patient howev fmrp bind translat machineri regul translat mrna target yet fulli understood show fmrp local translat machineri interact ribosom bind protein receptor activ c kinas rack bind fmrp rack remov translat repress activ fmrp promot translat psd mrna one specif target fmrp bind also result reduct level fmrp phosphoryl also find morpholog abnorm induc fmr sirna cortic neuron rescu overexpress mutant form rack bind ribosom thus result provid new mechan under fmrp activ contribut alter develop fxs moreov data confirm role ribosom rack ribosom scaffold rna bind protein | D051860;D005600;D000075370 | T047;T123;T116;T192 |
36,233,158 | genom wide identif evolut analysi rr myb gene famili reveal subfamili rr myb transcript factor involv anthocyanin biosynthesi carrot taproot purpl carrot accumul rich anthocyanin non purpl carrot myb transcript factor tfs condit anthocyanin biosynthesi mani plant current genom wide identif evolut analysi rr myb gene famili role involv condit anthocyanin biosynthesi carrot still limit studi total carrot rr myb tfs identifi base carrot transcriptom genom databas classifi subfamili basi rr myb domain rr myb gene uneven distribut among nine chromosom ka ks analysi suggest evolv purifi select anthocyanin relat subfamili contain myb tfs isol rr myb tfs anthocyanin content rhizodermi cortex secondari phloem black nebula cultivar reach highest among solid purpl carrot cultivar day sow approxim fold higher deep purpl ziwei cultivar respect express level myb gene purpl carrot higher non purpl carrot among dcmyb dcar specif express rhizodermi cortex secondari phloem tissu purpl haze cultivar highest express level compar control dpp cultivar day sow dcmyb dcar detect purpl root tissu dpp cultivar express level rhizodermi cortex secondari phloem fold higher secondari xylem day sow result use determin precis role subfamili rr myb tfs particip anthocyanin biosynthesi carrot | D018552 | T168;T002 |
36,233,157 | protect effect nopal cactus opuntia ficus indica seed oil short term lipopolysaccharid induc inflamm peroxisom function dysregul mous brain liver exposur endotoxin lipopolysaccharid lps may lead potent inflammatori cytokin respons sever impair metabol caus tissu injuri protect effect provid cactus seed oil cso opuntia ficus indica evalu lps induc inflamm dysregul peroxisom antioxid oxid activ brain liver tissu short term lps exposur increas proinflammatori interleukin il induc nitroxid synthas ino interleukin il brain cso action reduc lps induc ino express liver cso attenu main hepat il il regard peroxisom antioxid function cso treatment oliv oil oo colza oil co treatment induc hepat peroxisom cat gene paradox show cso well oo co treatment time induc catalas activ prevent induct lps respect brain liver tissu hand cso co pretreat prevent lps associ acox gene activ decreas liver collect cso show effici neuroprotect hepato protect effect lps maintain brain peroxisom antioxid enzym activ catalas glutathion peroxidas restor hepat peroxisom antioxid oxid capac | D029747 | T002 |
36,233,156 | effect aflatoxin b tumor relat gene phenotyp charact mcf mcfa cell fungal toxin aflatoxin b ab reactiv intermedi aflatoxin b epoxid could caus liver cancer induc dna adduct ab exposur induc chang express sever cancer relat gene studi effect ab exposur breast cancer mcf normal breast mcfa cell line phenotyp epigenet level investig evalu potenti increas risk breast cancer develop hypothes even low concentr ab caus chang express import gene involv four pathway ie p cancer cell cycl apoptosi transcriptom level brca brca p cmyc bcl mcl ccnd wnta mapk mapk dapk casp casp determin mcf mcfa cell result illustr treat cell ab induc cytotox apoptosi reduct cell viabil concentr depend manner addit ab reduc reactiv oxygen speci level phenotyp ab caus cell cycl arrest g hypertrophi increas cell migrat rate chang express level sever tumor relat gene known contribut activ cancer pathway effect ab phenotyp epigenet mcf mcfa cell associ cancer develop observ studi suggest ab potenti risk factor develop breast cancer | D016604;D016159 | T116;T131;T109;T196;T123 |
36,233,155 | gender differ hair length reveal crispr base product long hair mice dysfunct fgf mutat fibroblast growth factor fgf import molecul requir transit anagen catagen phase mammalian hair cycl previous report syrian hamster harbor bp delet fgf gene exhibit excess hair growth male herein generat fgf mutant mice use genom edit via oviduct nucleic acid deliveri gonad improv gonad gonad vivo genom edit system use target earli embryo present oviduct lumen studi gender differ hair length mutant mice two line fgfgo malc one bp delet cdel bp insert cinsa exon fgf success establish mutat predict disrupt part fgf domain frameshift mutat pgluvalfsx pgluargfsx fgfgo malc mice heterogen distribut longer hair wild type mice cblj notabl chang evid male femal p lt immunohistochem analysi reveal presenc fgf protein dermal papilla outer root sheath hair follicl cblj fgfgo malc mice histolog analysi reveal prolong anagen phase might caus acceler hair growth fgfgo malc mice | D051521;D006197;D012727 | T023;T123;T116;T032 |
36,233,154 | physiolog transcriptom analysi arabidopsi thaliana respons ailanthon potenti bio herbicid mani plant natur synthes secret secondari metabolit exert allelopath effect offer compel altern chemic herbicid natur herbicid high import sustain agricultur practic ailanthon chemic respons herbicid effect ailanthus altissima tree heaven molecular studi involv ailanthon effect plant growth limit current studi combin whole transcriptom physiolog analysi three arabidopsi thaliana ecotyp treat ailanthon identifi effect allelopath chemic gene plant growth physiolog result show reduc root growth high prolin accumul high reactiv oxygen speci accumul respons ailanthon stress deep transcriptom analysi reveal statist signific differenti express gene col cvi u ailanthon stress includ gene share among three access common gene includ upregul downregul gene vari express least twofold studi also reveal gene similar express pattern arabidopsi seedl subject herbicid differenti express gene signific induc respons ailanthon includ dtxl dtx abcc ndb ugt azi pathway stress develop hormon metabol signific alter ailanthon stress result suggest ailanthon trigger signific stress respons multipl pathway similar herbicid | D017360;D029681;D006540 | T131;T116;T002 |
36,233,153 | trypsinzn po hybrid nanoflow control synthesi excel perform immobil enzym immobil enzym signific technolog approach retain enzym activ reduc enzym catalyt cost work trypsin incorpor zn po hybrid nanoflow prepar via mild precipit coordin reaction control prepar hybrid nanoflow achiev systemat investig effect raw materi ratio materi concentr reaction temperatur product morpholog physicochem properti enzym content hybrid nanoflow maximum specif surfac area reach g hybrid nanoflow exhibit excel catalyt activ environment toler compar free trypsin attribut order accumul nanosheet proper anchor format enzym activ retent rate still higher repeat use therefor trypsinzn po hybrid nanoflow combin function excel heat resist storag stabil reusabl exhibit potenti industri applic prospect | D004800;D049329 | T073;T126;T116;T130 |
36,233,152 | dynam epigenet chang relaps recoveri cycl myalgic encephalomyelitischron fatigu syndrom myalgic encephalomyelitischron fatigu syndrom mecf complex diseas variabl sever patient experi frequent relaps symptom increas sever leav mark reduct qualiti life previous work investig molecular differ mecf patient healthi control dynam chang specif individu patient appli precis medicin map genom chang two select mecf patient period contain relaps recoveri cycl dna isol two patient healthi agegend match control regular interv captur patient relaps case reduc represent dna methyl sequenc profil obtain span relaps recoveri cycl patient show signific larger methylom variabl fold period sampl compar control relaps chang methylom profil two patient detect regulatori activ region genom associ respect downstream gene indic disturb metabol immun inflammatori function sever health relaps mecf patient result function import chang dna methylom differ two patient led similar compromis physiolog dna methyl signatur diseas variabl ongo mecf may practic applic strategi decreas relaps frequenc | D015673 | T047 |
36,233,151 | advanc mafld model human cell organoid model metabol dysfunct associ fatti liver diseas mafld one preval liver diseas approv therapeut high failur rate wit late phase mafld drug trial reflect complex diseas diseas develop progress remain fulli understood vitro human diseas model play pivot role mechanist studi unravel novel diseas driver drug test studi evalu human specif respons review focus mafld diseas model use human cell organoid model spectrum patient deriv primari cell immort cell line employ model various liver parenchym non parenchym cell type essenti mafld develop progress discuss divers form cell cultur platform util recapitul tissu level pathophysiolog differ stage diseas also review | D008107;D065626 | T047;T033 |
36,233,150 | quantit proteom analysi reveal yeast cell wall product influenc serum proteom composit broiler chicken ever grow market continu financi pressur associ prohibit antibiot growth promot poultri industri rapid develop non antibiot altern increas product yield possibl altern yeast deriv yeast cell wall ycw propos confer select benefici effect host anim effect ycw supplement broiler chicken investig use quantit proteom strategi wherebi serum obtain three group broiler fed distinct ycw base gut health product ghp control basal diet develop novel reagent enabl applic proteomin technolog sampl prepar subsequ compar quantit proteom analysi reveal protein show signific chang abund n individu protein p lt well protein uniqu identifi n absent n ghp fed treatment group versus control averag protein show chang abund ghp supplement sever effect ghps includ immunostimul via elev complement protein detect potenti alter oxid status anim eg glutathion peroxidas catalas stimul metabol process eg differenti abund glyceraldehyd phosphat dehydrogenas well evid possibl hepatoprotect effect attenu level serum glutathion transferas one ghp feed supplement observ propos specif protein detect may indic ghp efficaci stimul broiler immun status ie may biomark ghp efficaci summari work develop novel technolog prepar high dynam rang proteom sampl lc msms analysi part grow area livestock proteom import provid evidenti support benefici effect ghp supplement broiler chicken | D002645;D012441 | T012;T004 |
36,233,149 | systemat select repurpos drug candid covid sar cov caus covid pandem claim million live worldwid devast economi overwhelm healthcar system global develop new drug molecul vaccin play critic role manag pandem howev new variant concern still pose signific threat current vaccin prevent infect situat call collabor biomed scientist healthcar worker across world repurpos approv drug effect way fast track new treatment recent emerg diseas end assembl curat databas consist compound compound australia open drug collect develop set eight filter base indic efficaci safeti appli sequenti select drug show promis drug repurpos effort sar cov consider effort made evalu approxim assay data point sar cov fdatga approv drug provid averag activ score compound filter process identifi fda approv molecul establish safeti profil plausibl mechan treat covid diseas methodolog develop studi provid templat prioritis drug candid repurpos safe efficaci cost effect treatment covid long covid futur diseas present databas easi use interact interfac covirx also develop enabl scientif communiti access data potenti drug implement altern prioritis select strategi | D000086382 | T047;T067 |
36,233,148 | amyloid aggreg say long term potenti hippocampus activ stress induc phosphatas mitochondri na ca exchang search strategi strengthen synapt effici treat slice challeng compens amyloidosi relat patholog use record field excitatori postsynapt potenti fepsp nitric oxid imag measur serinethreonin protein phosphatas stpp activ detect function mitochondri paramet suspens brain mitochondria studi associ signal hippocampus aggreg shift kinas phosphatas balanc long term potenti ltp induct enhanc stpp activ ppppa inhibitor okada acid ppb blocker cyclosporin prevent depend ltp suppress simultan delay enzym blockad protocol stpp activ treat slice upregul revert relat control valu presenc ppppa presenc ppb blocker select inhibitor stress induc pp sephin ppa blocker cantharidin crucial mediat ltp suppress prevent mitochondri na ca exchang mncx blocker cgp also attenu induc ltp declin aggreg chang mitochondri transmembran potenti reactiv oxygen speci ros product affect ion transport ca depend swell organell stain hippocamp slice sensit fluoresc dye daf fm show stimul product pretreat slice dendrit contain region ca ca dentat gyrus dg cadg somata scaveng ptio nnos blockad select inhibitor br ni part restor induc ltp declin thus hippocamp product could anoth marker impair synapt plastic amyloidosi relat state kinas phosphatas balanc manag could promis strategi compens driven deterior | D000686;D017774 | T047;T042 |
36,233,147 | hydroxyvitamin serum level link singl nucleotid polymorph snps rs rs rs skelet muscl age institution elder men supplement vitamin sarcopenia sp loss skelet muscl mass associ age result involut muscl function strength vitamin defici common health problem worldwid especi among elder hypovitaminosi lead musculoskelet disord aim studi evalu impact presenc possibl linkag singl nucleotid polymorph snps cypr rs gc rs vdr rs serum ohd concentr link degre sarcopenia institution elder men supplement vitamin level oh vitamin quantifi commerci enzym link immunosorb assay kit snps genotyp kaspar assay signific differ ohd concentr determin bi allel combin rs rs detect statist signific weak posit correl aa rs rs tt rs allel ohd probabl higher ohd concentr fold higher howev gg allel snps show probabl optim hd concentr decreas rs rs rs show strong negat correl degre sarcopenia ohd level allel variat cypr rs gc rs vdr rs affect vitamin level decis influenc degre sarcopenia institution elder peopl | D053493;D000072467;D018167;D055948;D014808;D014809 | T047;T116;T192;T126;T123 |
36,233,146 | cellular senesc immun infect cellular senesc character irrevers cell cycl arrest respons differ trigger inflammatori secretom although origin describ fibroblast cell type solid organ cellular senesc affect tissu advanc age includ lymphoid tissu caus chronic inflamm dysregul innat adapt immun function besid normal occurr persist microbi challeng pathogen microorgan might also acceler activ cellular age induc prematur senesc immun cell therapeut strategi counteract detriment effect cellular senesc develop applic target immun cell might potenti improv immun dysfunct age reduc age depend suscept infect review discuss immun senesc influenc host abil resolv common infect elder detail differ marker propos identifi senesc cell mechan infecti agent increas extent immun senesc also review final avail senesc therapeut discuss context effect immun infect | D000375;D016922 | T043;T040;T033 |
36,233,145 | small heat shock protein collabor faim prevent accumul misfold protein aggreg cell tissu continu subject environment insult heat shock oxid stress caus accumul cytotox aggreg protein previous found fas apoptosi inhibitori molecul faim protect cell stress induc cell death prevent abnorm generat protein aggreg similar effect small heat shock protein hsps protein aggreg often associ neurodegen diseas includ alzheim diseas ad studi sought determin faim protein dynam chang cellular stress faim prevent format amyloid aggregatesfibril one patholog hallmark ad found major faim protein shift deterg insolubl fraction respons cellular stress similar shift insolubl fraction also observ small heat shock protein shsp famili molecul hsp stress demonstr faim recruit shsp contain complex cellular stress induct data suggest faim might prevent protein aggreg concert shsps fact observ addit effect faim hsp prevent protein aggreg use vitro amyloid aggreg model system work provid new insight interrelationship among faim shsps amyloid aggreg | D000544;D051017;D050888 | T047;T123;T116;T048 |
36,233,144 | physiolog transcriptom respons growth neolamarckia cadamba stimul exogen gibberellin phytohormon gibberellin gas play crucial role plant growth develop seed germin flower fruit stem elong although mani biolog role gas studi intens molecular mechan gas woodi plant still unclear studi investig effect exogen applic gas neolamarckia cadamba height biomass n cadamba increas day ga treatment especi second internod transcriptom analysi show although major gene involv ga signal pathway regul express ga oxidas gaox ga oxidas gaox regul day ga treat group compar ck group express cell elong relat basic helix loop helix gene bhlh bhlh regul ga treat group compar ck group transcript express level transcript factor involv hormon signal chang main includ bhlh ethylen respons factor erf wrki famili addit transcript express level key enzym engag phenylalanin pathway downregul ga treatment brief find reveal physiolog molecular mechan exogen ga treatment stimul n cadamba | D005875;D010937;D019666 | T116;T002;T109;T123;T125 |
36,233,143 | pathophysiolog therapeut role fascial hyaluronan obes relat myofasci diseas myofasci diseas import complic associ obes one lead caus physic disabl global face limit treatment option burden myofasci disord predict increas along escal preval obes sever patholog process obes contribut modif fascial extracellular matrix mechan biolog properti function chang adipos tissu metabol chronic inflammatori phenotyp oxid stress mechan obes may alter physiochem biomechan properti fascial hyaluronan understand pathophysiolog import hyaluronan compon fascial connect tissu matrix obes may shed light etiolog associ myofasci disord inform treatment strategi given uniqu favor pharmacolog properti hyaluronan found broad rang clinic applic notabl orthoped condit osteoarthr tendinopathi share import pathophysiolog mechan implic myofasci diseas howev exist clinic studi uniform affirm therapeut valu hyaluronan myofasci disord extens studi broader pharmacolog clinic context need firm valid therapeut adapt | D005205;D006820 | T023;T122;T121;T109;T123 |
36,233,142 | impact loss function variant hsdb hepat decompens mortal cirrhot patient common splice variant hsdb rs ta recent found associ reduc risk develop chronic liver diseas nafld patient reduc risk progress advanc fibrosi cirrhosi studi aim evalu prognosi cirrhot patient harbor variant perform retrospect analysi prospect recruit patient four differ hospit spain follow least year collect clinic demograph biochem data perform genotyp analysi common variant previous associ liver diseas risk hsdb rs ta pnpla rs patient homozyg ta allel show higher meld score p child turcott pugh score p inr level p well decreas albumin p baselin multivari analysi patient protect variant inde increas risk hepat decompens ahr p liver relat mortal ahr p specif patient increas risk develop ascit log r p lt hepat encephalopathi log r p lt higher mortal log r p lt year follow interact etiolog cirrhosi variant rs pnpla also describ find suggest variant rs ta hsdb protect effect inde increas risk decompens death patient advanc chronic liver diseas | D015067;D065626;D020641 | T047;T126;T116;T086 |
36,233,141 | mechan stress improv fat graft surviv promot adipos deriv stem cell prolifer cell assist lipotransf cal defin co transplant aspir fat enrich adipos deriv stem cell asc novel techniqu cosmet reconstruct surgeri overcom low surviv rate tradit fat graft howev clinic approv techniqu increas potenc asc cal develop yet clinic applic method use mechan stress reinforc potenc asc mechan stress appli inguin fat pad needl morpholog cellular chang adipos tissu examin flow cytometr analysi day procedur prolifer adipogenesi potenc asc evalu cal asc treat mechan stress sham control perform engraft determin week post oper flow cytometri analysi reveal mechan stress signific increas number well frequenc asc prolifer fat prolifer assay adipocyt specif marker gene analysi reveal mechan stress promot prolifer potenti affect differenti capac asc moreov cal cell deriv mechan stress treat fat increas engraft result indic mechan stress may simpl method improv efficaci cal enhanc prolifer potenc asc | D000273;D006085 | T042;T024;T201 |
36,233,140 | definit acceptor substrat bind specif plant xyloglucan endotransglycosylas use comput chemistri xyloglucan endotransglycosylas xet play key role remodel reconstruct plant cell wall enzym catalys homo transglycosyl reaction xyloglucan deriv donor acceptor substrat hetero transglycosyl reaction varieti structur divers polysaccharid work describ basi acceptor substrat bind specif non specif tropaeolum majus tmxet specif populus tremula x tremuloid pttxeta xet use molecular dock molecular dynam md simul combin bind free energi calcul data indic enzym donor xyloglucan heptaoligosaccharid xg os acceptor complex linear acceptor backbon consist glucos glc moieti link via glycosid linkag bound stabli activ site tmxet pttxeta convers acceptor link glc moieti bound stabli tmxet pttxeta link glc contain acceptor saccharid moieti replac mannos xylos bound stabli tmxet lack stabil pttxeta md simul xet donoracceptor complex acceptor deriv glucan highlight import glycosid linkag side chain posit acceptor substrat find explain differ acceptor bind specif non specif specif xet associ theoret experiment data | D000080486;D047071 | T121;T091;T109 |
36,233,139 | effect transglutaminas post treatment stabil swell behavior casein micro particl casein microparticl produc floccul casein micell due volum exclus pectin subsequ stabil film dri transglutaminas post treatment alter stabil swell behavior intern structur untreat particl sediment due size disintegr complet addit sodium dodecyl sulfat fact transglutaminas treat microparticl sediment compar rate condit show structur integr lost due deterg transglutaminas treat particl reach equilibrium final size swell instead decompos complet choos long treatment time swell also complet suppress experi ph show addit deswel effect also occur within swell curv enhanc increas transglutaminas treatment time ascrib elast network cross link casein propos structur model transglutaminas treat microparticl consist core uncross link shell cross link casein dynam model describ swell curv consid casein fraction parallel characterist correl length intern structur swollen casein microparticl ph independ decreas increas transglutaminas treatment time observ also equilibrium swell valu uncross link casein | D002364;D011503 | T121;T126;T123;T116 |
36,233,138 | b lymphoid blast phase chronic myeloid leukemia current therapeut blast crisi bc one dread complic chronic myeloid leukemia cml fortun incid bc diminish mark bcr abl tyrosin kinas inhibitor tki era primari object initi treatment bc achiev second chronic phase cp proceed allogen stem cell transplant sct elig patient clinic outcom patient cml bc remain unsatisfactori even high potent tkis remiss short live unmet need novel therapi provid comprehens summari review current manag lymphoid bc | D018380;D015464 | T191;T061 |
36,233,137 | omop cdm facilit data driven studi cancer predict systemat review current generat sequenc technolog led signific advanc identifi novel diseas associ mutat generat larg amount data high throughput manner data conjunct clinic routin data proven high use deriv popul level patient level predict especi field cancer precis medicin howev data harmon across multipl nation intern clinic site essenti step assess event outcom associ patient current adequ address observ medic outcom partnership omop common data model cdm intern establish research data repositori introduc observ health data scienc informat ohdsi communiti overcom issu address need cancer research genom vocabulari extens introduc support standard subsequ data analysi review evalu current potenti omop cdm applic cancer predict comprehens genom vocabulari extens omop serv current need ai base predict systemat screen literatur articl use omop cdm predict analys cancer investig under predict modelstool interest found articl use omop harmon data make use predict algorithm omop base data fulfil criteria studi present multicentr investig omop play essenti role discov optim machin learn ml base model ultim use omop cdm lead standard data driven studi multipl clinic site enabl solid basi util eg ml model reus combin earli predict diagnosi improv person cancer care biomark discoveri | D008490;D009369 | T191;T091;T066 |
36,233,136 | adenosin schizophrenia cancer purinerg system offer pathway treatment centuri complex relationship schizophrenia diagnosi develop mani cancer observ find epidemiolog studi mix report increas reduc differ cancer incid schizophrenia patient howev risk factor cancer includ elev smoke rate substanc abus common associ patient popul surpris cancer incid higher various factor may account propos reduct cancer incid rate includ pathophysiolog chang associ diseas perturb adenosin system hypothes contribut neurobiolog schizophrenia convers hyperfunct adenosin system found tumor microenviron cancer target adenosin system therapeut promis area research diseas outlin current biochem pharmacolog evid hypofunct adenosin system schizophrenia role increas adenosin metabol tumor microenviron context relat limit literatur patient popul discuss whether hypofunct system schizophrenia may counteract immunosuppress role adenosin tumor microenviron also highlight import studi examin adenosin system subset patient potenti insight may offer complex disord | D009369;D012559 | T191;T048 |
36,233,135 | serpin dna methyl level quantifi blood cell five year age associ adipos plasma pai level five year age plasminogen activ inhibitor pai express associ higher risk develop obes dna methyl dnam epigenet mechan regul gene transcript like involv fetal program childhood obes studi aim assess associ pai gene serpin dnam plasma pai level adipos five year age analyz dnam anthropometr data girl boy geng prospect birth cohort assess adipos use bmi z score waist circumfer total skinfold percentag total android trunk fat measur dual energi radiographi dxa estim blood cell dnam level cpg site within serpin use methylationep array correct multipl test found lower dnam serpin intron cg associ greater adipos level girl waist circumfer r p skinfold r p android fat r p bmi z score r p lt lower dnam serpin promot cg associ higher plasma pai level boy r p studi suggest dnam level serpin gene locus negat correl adipos plasma pai level young girl | D050154;D063766;D017395 | T047;T116;T123;T032;T033 |
36,233,134 | role zntd neurodevelop pathogenesi alzheim diseas drosophila melanogast model zinc fundament trace element essenti numer biolog process zinc homeostasi regul zrt irt like protein zip zinc transport znt famili znt main local golgi apparatus endoplasm reticulum er transport zinc organell although previous studi report role zinc anim physiolog littl known import zinc golgi apparatus er anim develop neurodegen diseas studi demonstr zntd drosophila ortholog znt play pivot role neurodevelop pathogenesi alzheim diseas ad zntd silenc neuron embryo adult surviv rate locomotor activ lifespan dramat reduc toxic phenotyp accompani abnorm neurogenesi neuron cell death furthermor knockdown zntd neuron drosophila ad model increas apoptosi exacerb neurodegener without signific chang deposit amyloid beta plaqu suscept oxid stress taken togeth result suggest appropri distribut zinc golgi apparatus er import neuron develop neuroprotect znt potenti protect factor ad | D000544;D027682;D014131 | T047;T116;T121;T123;T196;T048 |
36,233,133 | aggregatibact actinomycetemcomitan cytoleth distend toxin induc cell cycl arrest glycogen synthas kinas gsk depend manner oral keratinocyt cytoleth distend toxin cdt produc divers group pathogen one cdt produc organ aggregatibact actinomycetemcomitan play critic role pathogenesi uniqu form periodont former refer local aggress periodont activ cdt subunit cdtb potent phosphatidylinositol pi triphosph phosphatas capabl induc pi kinas signal blockad requisit cdt induc toxic lymphocyt studi extend observ includ oral keratinocyt respons aa cdt use cell line primari gingiv keratinocyt three exhibit gm arrest expos aa cdt toxin within h toxin treat cell exhibit reduc level pakt pgsk within h pre treatment gsk kinas inhibitor ly chir tideglusib abrog cdt induc gm arrest none oral epitheli cell exhibit evid apoptosi cell remain arrest gm phase least h without evid dna damag respons activ hax phosphoryl cdt treat cell display increas phosphoryl cyclin depend kinas cdk moreov gsk inhibitor block increas reduc total cdk level studi clarifi potenti mechan contribut cdt toxic toxin mediat pathogenesi | D016976;D010520 | T007;T047 |
36,233,132 | epitranscriptom mechan metal toxic carcinogenesi metal common toxic environment pollut acut chronic exposur metal pollut caus sever advers health effect anim human development retard abnorm metabol disord cardiovascular neurolog respiratori reproduct urolog system moreov sever metal arsenic cadmium chromium nickel classifi potent group carcinogen caus various type cancer human although toxic carcinogen metal pollut well recogn under mechan clear defin epitranscriptom includ kind chemic modif form rna molecul insid cell recent progress demonstr revers pattern rna modif role physiolog pathogenesi repres breakthrough field rna biolog function studi epitranscriptom studi excit emerg field toxicolog research studi conduct far determin epitranscriptom effect metal pollut offer novel insight understand mechan metal toxic carcinogenesi goal review discuss recent studi epitranscriptom effect metal propos thought futur studi field | D001151;D004785 | T121;T131;T196 |
36,233,131 | toward sustain carbon return wast industri via c type molecular unit general possibl sustain cycl carbon return high valu ad product discuss turn wast acetylen pyrolyz solid municip wast pyrolyz use cation exchang wast carbon sourc studi view design sustain cycl produc calcium carbid acetylen yield calcium carbid carbon wast high industri fossil raw materi coke charcoal etc convers carbon contain wast calcium carbid provid excel opportun make acetylen direct compat modern industri overal process return carbon contain wast back sustain cycl produc high valu ad product involv c type molecul calcium carbid acetylen calcium carbid may store transport demand acetylen generat easi realiz upon incorpor wast process rout calcium carbid may effici carbon reservoir quick industri uptak | D002244;D003077 | T121;T167;T196 |
36,233,130 | dock molecular dynam base identif interact various beta amyloid isoform rage receptor beta amyloid peptid ligand associ rage advanc glycosyl end product specif receptor transloc complex rage blood brain across blood brain barrier bbb transcytosi isoform import factor alzheim diseas ad pathogenesi howev interact rage previous studi isoform present studi direct identifi key interact interfac rage isoform phosphoryl isomer isoform ps isod two interfac identifi dock repres extend area junction rage domain v c smaller area link c c domain molecular dynam md simul shown isoform form stabl tight bound complex indic isoform potenti transport cell part complex rage model rage interact interfac indic chemic compound potenti capabl block interact impair associ pathogen cascad abil three rage inhibitor rap fps zm rp disrupt rage interact probe dock subsequ complex stabil verifi md rp interact area coincid therefor inhibitor promis rage interact inhibit | D000544;D016229 | T047;T116;T048 |
36,233,129 | linear nonlinear regress analysi adsorpt remazol dye romanian breweri wast product saccharomyc cerevisia earth water balanc economi becom increas fragil due overpopul global warm sever environment pollut surfac groundwat pollut therefor essenti find solut problem water scarciti water pollut research experi design optim techniqu adsorpt remazol red fb rr dye lyophil breweri yeast wast ferment process moreov prove breweri yeast great adsorb batch adsorpt experi carri optim differ initi paramet initi dye concentr mgl amount yeast g ph temperatur c furthermor structur element composit adsorb analyz sem ed ftir biosorpt best fit mathemat isotherm model case linear form langmuir freundlich model r r nonlinear form khan model r best fit pseudo second order kinet model show best fit linear plot tq vs nonlinear form calcul q e valu similar experiment data | D014874;D018508 | T057;T131;T052 |
36,233,128 | supramolecular deconstruct bamboo holocellulos via hydrotherm treatment high effici enzymat convers low enzym dosag hydrotherm pretreat htp long consid effici green treatment process lignocellulos biomass bioconvers howev variat cellulos supramolecular structur htp well effect subsequ enzymat convers less understood work bamboo holocellulos well connect cellulos hemicellulos polysaccharid hydrotherm treat various temperatur chemic morpholog crystal structur determin perform systemat seri advanc character xylan degrad xylooligosaccharid hydrolyz accompani reduc degre polymer cellulos cellulos crystallit found swell anisotrop despit limit decrystal htp hydrogen bond linkag cellulos molecular chain weaken due chemic crystal variat therefor swell loosen separ condens cellulos microfibril sampl htp present notabl increas surfac area favor adsorpt subsequ hydrolysi cellulas enzym satisfi enzymat convers yield gt rather low cellulas enzym dosag fpug glucan obtain would indic new understand green effici bioconvers process lignocellulos biomass | D002480;D008031 | T116;T121;T109;T126;T123 |
36,233,127 | endoplasm reticulum homeostasi regul tlr express signal mast cell endoplasm reticulum er dynam organell respond demand secretori protein undergo expans mechan control homeostasi er size function involv activ unfold protein respons upr upr play role various effector function immun cell mast cell mcs high granular tissu resid cell key driver allerg inflamm divers secretori function respons activ high affin receptor ige fcri suggest role upr function use human cord blood deriv mcs found fcri trigger elev express level induc activ upr transduc ire perk accompani expans er mous bone marrow deriv mcs periton mcs er underw moder expans upr induc follow mc activ delet ire mous mcs affect prolifer surviv degranul cytokin stimul follow fcri trigger diminish surfac express tlr consequ respons lps similar phenotyp observ human mcs use ire inhibitor data indic er mcs primarili human undergo rapid remodel respons activ promot respons tlr suggest ire inhibit strategi inhibit hyperactiv mcs lps cours allerg respons | D004721;D004722;D017346;D051197 | T026;T126;T116;T192 |
36,233,126 | model studi interact subleth dose zinc oxid nanoparticl environment benefici bacteria bacillus thuringiensi bacillus megaterium zinc oxid nanoparticl zno nps due antibacteri effect common use various branch economi affect rhizobacteria promot plant growth describ effect zno nps two model bacteria strain b thuringiensi b megaterium play import role environ mic minimum inhibitori concentr valu determin h incub zno nps mgml strain test mbc minimum bactericid concentr mgml test effect zno nps concentr mic mgml mgml mgml equal mic respect order identifi mechan activ bacillus speci presenc nanoparticl zno nps subleth concentr inhibit plankton cell growth stimul endospor format reduc decolor evan blue addit zno nps caus oxid stress measur use nitroblu tetrazolium nbt reduc activ catalas confirm zinc oxid nanoparticl subleth concentr chang metabol process bacillus bacteria import effect environ b thuringiensi treatment zno nps decreas indol acet acid iaa product increas biofilm format wherea b megaterium decreas iaa product invers increas biofilm format comparison differ bacillus speci singl experi made possibl better understand mechan toxic zinc oxid nanoparticl individu reaction close relat bacteri speci | D001410;D001413;D053768;D053758;D015034 | T007;T073;T197;T121 |
36,233,125 | conup bsa seq rna seq reveal molecular pathway gene associ plant height foxtail millet setaria italica foxtail millet setaria italica play import role c crop research agricultur develop arid area due short growth period drought toler barren toler explor dwarf mechan dwarf gene foxtail millet provid refer dwarf breed dwarf research c crop studi genet analysi perform use phenotyp data candid gene screen bulk segreg analysi sequenc bsa seq differenti express gene metabol pathway differ strain high sampl analyz rna sequenc rna seq associ analysi bsa seq rna seq narrow candid rang result total three quantit trait loci qtls nine candid gene relat plant height obtain chromosom ix base function predict candid gene propos hypothet mechan format millet dwarf metabol mapk signal play import role format foxtail millet plant height | D032983 | T002 |
36,233,124 | target phospholipas pharmacolog prevent phagocyt function loss retin pigment epithelium cell expos high glucos level previous describ particip canon phospholipas isoform pld pld inflammatori respons retin pigment epithelium rpe cell expos high glucos concentr hg studi role pld pathway rpe phagocyt function purpos arp cell expos hg mm normal glucos concentr ng mm phagocytosi measur use phrodo green bioparticl photoreceptor outer segment pos hg exposur h reduc phagocyt function arp cell loss function prevent cell treat pld vu pldi pld vu pldi select inhibitor furthermor pldi pldi affect rpe phagocytosi physiolog condit prevent oxid stress induc hg addit demonstr pld pld express abc cell novel human rpe cell line physiolog condit pldi pldi affect abc cell viabil partial silenc plds affect abc cell pos phagocytosi conclus pldi pldi prevent loss phagocyt function rpe cell expos hg without affect rpe function viabil non inflammatori condit | D010739 | T126;T116 |
36,233,123 | pinc tool non code rna identif plant base autom machin learn framework evid non code rnas play signific role regul nutrient homeostasi develop stress respons plant accur identif ncrnas first step determin function number machin learn tool develop ncrna identif dedic tool develop ncrna identif plant autom machin learn tool pinc present identifi ncrnas plant use rna sequenc first extract featur sequenc second combin f test varianc threshold featur select find featur autogluon framework use train model robust identif non code rnas dataset construct four plant speci last process combin tool call pinc identif plant ncrnas valid nine independ test set accuraci pinc rang compar cpc cpat cppred cnit pinc outperform tool least five eight evalu indic pinc expect contribut identifi annot novel ncrnas plant | D000069550;D022661 | T066;T114 |
36,233,122 | cthh regul lps induc inflamm il signal mac cell hydrogen sulfid h endogen gaseous signal molecul play import role inflammatori process previous studi found cystathionin lyas cth h correl occurr develop clinic mastiti cm holstein cow howev function regulatori mechan cthh still unknown studi inflammatori mammari cell model base mac cell line establish lipopolysaccharid lps induc manner explor function regulatori mechan cthh cow cm inflammatori mac cell cth express h product repress lps dose depend manner demonstr cthh relat progress inflamm inhibit cthh use select cth inhibitor cyano l alanin bca promot lps induc inflamm respons express inflammatori cytokin howev revers h donor nah demonstr h protect cell inflammatori damag intrigu interleukin il show invers express pattern correl h mediat cell protect effect inflamm process inhibit test use select il receptor antagonist sb show il signal play critic role mediat endogen h synthesi cthh exert anti inflamm via il mediat signal studi provid support prevent treatment cm develop novel anti inflammatori strategi | D006862;D008070 | T109;T131;T130;T197 |
36,233,121 | perspect use fucoidan clinic oncolog fucoidan natur sulfat polysaccharid wide rang biolog function regard promis antitumor agent activ various fucoidan deriv demonstr vitro tumor cell differ histogenesi experi mice graft tumor howev experiment model show low level antitumor activ clinic trial prove class compound could serv antitumor drug nevertheless anti inflammatori antiangiogen immunostimul anticoagul properti fucoidan well abil stimul hematopoiesi cytostat base antitumor therapi suggest effect fucoidan base drug could design support care symptomat therapi cancer patient use fucoidan cancer patient chemotherapi radiat therapi might promot rapid improv hematopoiesi anti inflammatori immunomodulatori anticoagul effect potenti improv qualiti life patient advanc cancer | D054697;D009369 | T121;T191 |
36,233,120 | spermin suppress adipocyt differenti exert anti obes effect vitro vivo endogen polyamin putrescin put spermidin spd spermin spm affect adipocyt differenti studi investig effect exogen supplement polyamin mous adipocyt differenti anti obes action vitro vivo preadipocyt cell line l cultur put spd spm lipid accumul cell measur oil red stain lipid accumul signific suppress spm suppress ccaatenhanc bind protein mrna spm suggest decreas lipid accumul due delay cell differenti bodi weight fat obes mice induc high fat diet reduc oral ingest spm conclus oral supplement spm abil prevent obes inhibit adipocyt differenti | D019440;D013096 | T121;T109;T123 |
36,233,119 | nestin mesenchym precursor generat distinct spleen stromal cell subset immunomodulatori function mesenchym stromal cell mscs known widespread mani tissu possess broad spectrum immunoregulatori properti use treatment varieti inflammatori diseas howev therapeut effect still inconsist owe heterogen spleen stromal cell evolv regul immun respons mani level bath complex inflammatori milieu infect therefor unknown whether stronger immunomodulatori effect counterpart deriv tissu use transgen mous model express gfp driven nestin nes promot nes gfp cell bone marrow spleen collect artifici lymphoid reconstruct vivo perform cell phenotyp inhibit cell inflammatori cytokin vivo therapeut effect assess observ nes gfp cell coloc splenic stromal cell demonstr nes gfp cell abil establish ectop lymphoid like structur vivo moreov show nes gfp cell possess characterist mscs spleen deriv nes gfp cell exhibit greater immunomodulatori abil vitro remark therapeut efficaci inflammatori diseas especi inflammatori bowel diseas ibd bone marrow deriv nes gfp cell overal data show nes gfp cell contribut subset spleen stromal popul possess biolog characterist mscs stronger immunoregulatori function therapeut potenti bone marrow deriv nes gfp cell | D013154;D017154 | T023;T025 |
36,233,118 | inflamm driven secret potenti upregul osteoarthrit fibroblast like synoviocyt osteoarthr oa one common joint patholog major caus disabl among popul develop countri manifest gradual degener cartilag subchondr part bone lead joint damag recent studi indic cell make articular cartilag also synoviocyt build membran surround joint contribut develop oa therefor aim studi determin respons inflammatori factor osteoarthrit synoviocyt identifi protein secret may influenc progress oa studi demonstr fibroblast like synoviocyt oa patient fls oa respond strong pro inflammatori stimul cell obtain control patient fls chang observ transcriptom level subsequ confirm protein analysi fls oa stimul pro inflammatori factor lipopolysaccharid lps tumor necrosi factor alpha tnf shown secret signific chemokin cxcl cxcl cxcl growth factor angiopoietin like protein angptl fibroblast growth factor fgf insulin like growth factor igf control cell moreov translat proteolyt enzym matrix metalloproteas mmp cathepsin k ctsk cathepsin ctss fls oa increas inflammatori condit data indic fls oa patient function alter result enhanc respons presenc pro inflammatori factor environ manifest increas product previous mention protein may promot diseas progress | D010003;D013002;D000070918 | T047;T025;T116;T125 |
36,233,117 | associ marc adci bco variant lipid profil suggest addit effect hypertriglyceridemia mexican adult men epidemiolog studi report mexican popul high suscept dyslipidemia marc adci bco gene recent involv lipid abnorm studi aim analyz associ singl nucleotid polymorph snps rs rs rs marc adci bco gene respect lipid profil cohort mexican adult includ mexican adult health worker cohort studi demograph clinic data collect structur questionnair standard procedur genotyp perform use predesign taqman assay genet risk score grs creat basi three genet variant associ analysi estim use linear logist regress result show rs rs allel risk associ hypertriglyceridemia p p respect rs c allel trend low hdl c p men grs reveal signific associ hypertriglyceridemia p find provid evid aggreg effect marc adci bco variant risk hypertriglyceridemia mexican men knowledg could repres tool identifi risk male might benefit earli intervent avoid secondari metabol trait | D000262;D015228;D050559 | T047;T126;T116 |
36,233,116 | high conserv interact profil clinic relev mutant cytomegalovirus cdk like kinas pul human cyclin function signific cyclin h complex host interact network human cytomegalovirus hcmv involv regulatori protein kinas pul repres viral cyclin depend kinas cdk ortholog pul interact three human cyclin type h b wherebi bind region cyclin pul oligomer region assign amino acid address question whether hcmvs harbor mutat orf ul ie short delet resist confer point mutat affect interact human cyclin viral replic end clinic relev ul drug resist confer mutant analyz whole genom sequenc use genet marker transfer experi recombin hcmvs indic conserv pul cyclin interact sinc viral ul point mutant continu interact analyz cyclin type exert wild type like replic fit comparison recombin hcmvs ul also smaller delet lost interact cyclin h show impair replic effici also exhibit reduc kinas activ moreov cellular knock cyclin b alter hcmv replic phenotyp pul kinas activ possibl indic altern compensatori pul cyclin interact contrast howev cyclin h knock similar virus delet mutant pul cyclin h bind region exhibit strong defect phenotyp hcmv replic support reduc pul kinas activ cyclin h depend coexpress set thus cyclin h prove relev determin pul kinas activ viral replic effici conclus result provid evid function import pul cyclin interact high select pressur format pul cyclin complex identifi use clinic relev mutant | D056748;D003587;D014764 | T005;T123;T116 |
36,233,115 | circul redox biomark diagnost signific alcohol intox peopl toxic properti ethanol inextric link oxid stress despit mani report effect alcohol depend blood redox homeostasi data oxid stress profil alcohol poison case also data diagnost use redox biomark determin post mortem various biolog fluid work investig util enzymat non enzymat antioxid barrier redox status oxidativenitros stress biomark differ biolog fluid blood urin vitreous humor cerebrospin fluid post mortem studi patient acut alcohol intox studi group includ die due acut ethanol intox n research show signific increas glutathion peroxidas activ total antioxid status ferric reduc antioxid power tryptophan concentr studi group urin compar control circul fluid antioxid enzym activ glycoxid product concentr signific differ individu die alcohol overdos compar die sudden also observ connect oxid reduct balanc amount alcohol consum death unexpect observ may caus irrevers post mortem chang occur cellular level due autolysi putrefact summari use circul bodi fluid assess redox homeostasi limit post mortem analysi result indic increas stabil urin collect post mortem compar circul bioliquid studi need assess intens oxid carbonyl stress ethanol damag organ effect post mortem process cellular redox balanc | D000435;D000437 | T048 |
36,233,114 | aqp ac polymorph affect aqp promot methyl quantiti aquaporin protein neutrophil granulocyt associ human sepsi surviv c allel aquaporin aqp ac polymorph shown associ decreas aqp express shown relev context lead toward improv outcom sepsi date under mechan c allel lead lower aqp express unknown know detail mechan depict crucial step target intervent genotyp depend regul aqp express might mediat epigenet mechan promot methyl treatment epigenet drug could mayb provid benefit henc test hypothesi aqp promot methyl differ genotyp specif type immun cell aqp promot methyl quantifi cell septic patient control methyl specif polymeras chain reaction quantifi standard curv cell line model aqp express analyz demethyl determin impact promot methyl aqp express c allel aqp ac promot polymorph associ five fold increas promot methyl neutrophil p four fold increas monocyt p lymphocyt p septic patient healthi control well addit decreas aqp promot methyl accompani increas aqp express hl p reh cell p c allel associ lower gene express sepsi accompani higher methyl level aqp promot henc aqp promot methyl could depict key mechan genotyp depend express | D051402;D019175;D011401;D018805 | T047;T046;T116;T123;T114;T044 |
36,233,113 | imatinib mesyl induc necroptot cell death impair autophag flux human cardiac progenitor cell receptor tyrosin kinas inhibitor imatinib improv patient cancer surviv link cardiotox studi investig imatinib effect cell viabil apoptosi autophagi necroptosi human cardiac progenitor cell vitro imatinib reduc cell viabil vs concentr compar peak plasma level imatinib reduc cell tmrm fluoresc vs consist mitochondri depolaris imatinib increas lysosom autophagosom content indic lamp express fold acridin orang fluoresc vs respect although imatinib increas express autophagi associ protein also impair autophag flux shown proxim ligat assay stain lamp lcii autophagosom marker h imatinib treatment reduc visibl puncta cell punctacel control cell viabil partial recov autophagosom inhibit wortmannin viabil increas imatinib wortmannin co treatment imatinib imatinib induc necroptosi associ fold increas mix lineag kinas domain like pseudokinas activ imatinib induc toxic rescu rip inhibit vs control imatinib appli human cardiac progenitor cell depolaris mitochondria induc cell death necroptosi recover rip inhibit partial role autophagi | D000165;D001343 | T043;T109;T130 |
36,233,112 | aryl cap lysin dehydroamino acid dipeptid supergel potenti drug releas system employ amino acid peptid molecular build block provid uniqu opportun generat supramolecular hydrogel owe inher biolog origin bioactiv biocompat biodegrad howev suffer proteolyt degrad short peptid lt amino acid attach aromat cap group particular attract altern minimalist low molecular weight hydrogel peptid low critic gelat concentr cgcs especi desir low weight percentag requir gelat make cost effect reduc toxic work three dehydrodipeptid studi self assembl properti result show three dehydrodipeptid form self stand hydrogel low critic gelat concentr wt use ph trigger hydrogel three dehydrodipeptid characteris scan tunnel emiss microscopi stem rheolog fluoresc spectroscopi circular dichroism cd spectroscopi molecular model perform probe structur pattern interact cytotox new compound test use human keratinocyt hacat cell line general result suggest three compound non cytotox although one peptid show small impact cell viabil sustain releas assay effect charg model drug compound rate cargo releas hydrogel network evalu hydrogel provid sustain releas methyl orang anion ciprofloxacin neutral methylen blue cation retain network | D004151;D008239 | T121;T123;T116 |
36,233,111 | diversifi effect covid consequ differenti metabol phospholipid lipid peroxid evalu plasma survivor deceas patient upon admiss hospit result sar cov infect inflamm develop promot oxid stress lead modif phospholipid metabol therefor aim studi compar effect covid level phospholipid free polyunsatur fatti acid pufa metabolit produc respons reaction reactiv oxygen speci ros enzym cyclooxygenas cox lipoxygenas lox plasma patient either recov pass away within week hospit plasma covid patient especi survivor action ros phospholipas pla caus decreas phospholipid fatti acid level increas free fatti acid especi arachidon acid despit increas cox lox activ accompani increas level lipid peroxid product malondialdehyd isoprostaglandin f lipid mediat generat enzym also increas eicosanoid pro inflammatori follow thromboxan b prostaglandin e anti inflammatori follow deoxi prostaglandin j hydroxyeicosatetraeno acid well endocannabinoid anandamid aea arachidonylglycerol ag observ plasma patient recov moreov express tumor necrosi factor interleukin il il increas patient recov howev group patient die elev level n oleoylethanolamin n palmitoylethanolamin found sinc lipid mediat may differ function depend onset pathophysiolog process stronger pro inflammatori respons patient recov may result defens respons sar cov survivor associ specif chang phospholipid metabol could also consid prognost factor | D000086382;D063388 | T047;T109;T123;T067 |
36,233,110 | site specif glycan microheterogen evalu aflibercept fusion protein glycopeptid base lc msms map evalu protein glycosyl state sampl aflibercept obtain three differ region conduct site specif n link glycan microheterogen profil glycopeptid base nano lc msms map tryptic digest sampl aflibercept lot provid site specif inform glycan microheterogen five n glycosyl site two site vegfr region two site vegfr region one site human igg fc region next glycopeptid map result obtain three differ aflibercept lot compar evalu similar sampl three aflibercept lot show high degre similar glycan composit fucosyl level sialyl level branch five n glycosyl site assess togeth group hand notic variat lot glycan type sialyl level two site vegfr domain observ five n glycosyl site assess use glycopeptid base method presenc n glycolylneuramin acid neugc glycan may mediat advers immun reaction antibodi therapeut also detect site vegfr vegfr domain igg fc domain site result impli analys glycosyl profil fusion protein contain multipl n glycosyl site aflibercept done part qualiti control therapeut manufactur process biosimilar develop done applic outcom assess site separ | D059451;D006020 | T121;T116 |
36,233,109 | safeti tepotinib challeng capmatinib induc pneumon patient non small cell lung cancer harbor met exon skip mutat case report target agent capmatinib tepotinib provid new treatment patient non small cell lung cancer nsclc met exon skip mutat metex howev drug induc pneumon uncommon threaten advers effect found patient treat capmatinib tepotinib safeti treat patient met inhibitor drug induc pneumon anoth met inhibitor remain unclear present case patient nsclc harbor metex treat standard dose tepotinib advanc capmatinib induc pneumon present pneumon relaps tepotinib may safe option medic profession consid switch met inhibitor patient experi pneumon | D002289;D008175;D011014 | T191;T050;T047 |
36,233,108 | ration design thermost deoxyribosyltransferas nelarabin product predict disulfid bond engin site one major drawback industri implement enzymat process low oper stabil enzym tough industri condit respect use thermost enzym industri gain ground last decad herein report structur guid approach develop novel thermost deoxyribosyltransferas ndts base comput design disulfid bond hot spot posit end small librari ndt variant lactobacillus delbrueckii ld ndt introduc cystein pair creat among ld ndt sc retain activ chosen thermost variant display six two fold enhanc long term stabil store c amp nbsp c h c amp nbsp c h respect moreov biochem character reveal ld ndt sc show gt relat activ across broad rang temperatur c ph final studi potenti applic ld ndt sc industri catalyst enzymat synthesi nelarabin success carri differ substrat condit differ reaction time experiment condit product nelarabin increas fold convers compar wild type ld ndt | D004800;D010430 | T126;T116;T130 |
36,233,107 | review defat strategi non alcohol fatti liver diseas non alcohol fatti liver diseas huge caus chronic liver failur around world condit becom preval rate metabol syndrom type diabet obes also escal unfortun outcom mani peopl liver cirrhosi warrant transplant unabl receiv transplant sinc mani liver discard due high level steatosi past sever year howev great deal work gone understand pathophysiolog diseas well possibl treatment option review summar various defat strategi includ vitro use pharmacolog agent machin perfus extract liver genom approach target specif protein goal field reduc number necessari transplant expand pool organ avail use | D003924;D016031;D065626 | T061;T047 |
36,233,106 | chemoenzymat synthesi optic activ ether analog iso moramid novel potenti power analges develop potent safer analges design synthes novel enantiomer enrich ether analog r iso moramid name r morpholin yl propoxi diphenyl pyrrolidin yl ethan one titl activ agent potenti serv power synthet opiat improv affin select toward opioid receptor or hypothesi postul base dock studi regard respect complex design ligand key step elabor asymmetr synthesi novel analog involv lipas catalyz kinet resolut racem morpholin yl propan ol accomplish g scale via enantioselect transesterif employ vinyl acet irrevers acyl donor tert butyl methyl ether mtbe co solvent next obtain homochir morpholino alcohol gt ee function correspond chloro deriv use thionyl chlorid socl appel reaction condit transform n diphenylacetyl pyrrolidin phase transfer catalysi ptc condit use satur dmsonaoh mixtur oxid furnish desir levorotatori isom titl product isol total yield three step ee absolut configur key intermedi r iso moramid determin use modifi form mosher methodolog prepar optic activ dextrorotatori isom titl product ee carri essenti rout util r morpholin yl propan ol ee key intermedi spectroscop character ether analog iso moramid enantioselect retent relationship enantiom use hplc cellulos base chiral stationari phase perform moreov proof principl singl crystal x ray diffract xrd analysi synthes r morpholin yl propoxi diphenyl pyrrolidin yl ethan one report | D004987;D053610 | T121;T109;T131 |
36,233,105 | epigenet modul opioid receptor drug abus chronic exposur drug abus produc profound chang gene express neural activ associ drug seek take behavior dysregul opioid receptor gene express common observ across varieti abus substanc includ opioid cocain alcohol earli studi cultur cell show spatial tempor gene express opioid receptor regul epigenet mechan includ dna histon modif non code rnas accumul evid indic drug abus modul opioid receptor gene express target various epigenet regulatori network base current cellular anim model substanc use disord clinic evid review summar chronic drug exposur alter gene express mu delta kappa nociceptin receptor via dna histon modif influenc drug abus epigenet modul non code rnas transcript factor also present final therapeut potenti manipul epigenet process avenu treat substanc use disord discuss | D003042;D019966 | T131;T121;T109;T048;T033 |
36,233,104 | physiolog transcript analysi reveal respons mechan camellia vietnamensi huang drought stress drought stress consid main obstacl restrict camellia vietnamensi huang c vietnamensi yield hainan southernmost distribut region c vietnamensi china experi drought period annual studi drought stress respons mechan c vietnamensi treat seedl drought toler hd drought sensit wh cultivar peg peg simul drought stress compar physiolog transcriptom leav posttreat drought stress growth c vietnamensi inhibit relat water content rwc leav decreas content malondialdehyd mda antioxid enzym activ osmot regulatori substanc secondari metabolit increas compar wh leaf rwc osmot regul substanc content prolin solubl protein solubl sugar antioxid enzym activ superoxid dismutas peroxidas catalas hd signific increas relat electr conduct mda content signific decreas compar wh differenti express gene deg detect hd posttreat respect number deg increas increas treatment time detect deg involv drought stress respons c vietnamensi main plant hormon signal transduct lignin flavonoid biosynthesi pathway drought stress signific activ express sever lignin flavonoid biosynthesi gene hd moreov total flavonoid total polyphenol content hd signific increas suggest accumul flavonoid may key factor drought stress respons c vietnamensi addit deg associ code transcript factor tfs studi provid insight molecular mechan drought stress respons c vietnamensi provid theoret basi develop cultiv new drought resist cultivar | D028244;D055864 | T002;T070 |
36,233,103 | first molecular detect aed albopictus sudan associ increas outbreak chikungunya dengu part survey invas malaria vector anophel stephensi four sudanes state includ north south kordofan sennar white nile collect larva morpholog identif confirm collect mosquito sampl anophel speci name gambia sl stephensi aed specimen ae luteocephalus ae aegypti ae vexan ae vittatus ae africanus ae metalicus ae albopictus consid serious threat ae albopictus emerg public health area limit resourc priorit ae albopictus sampl genom analysi extract dna three specimen subsequ sequenc cytochrom oxidas co gene confirm ident aed albopictus potenti origin phylogenet haplotyp analys aed albopictus origin southeast asia invas key vector chikungunya dengu first report molecular character ae albopictus sudan sequenc cluster popul central african republ la runion worri find associ major increas chikungunya dengu outbreak rural area studi region might link mosquito spread across region emerg ae albopictus sudan serious public health concern urg improv vector surveil control system implement integr molecular xenosurveil threat major arbovir diseas region underlin need institution one health strategi prevent control futur pandem | D000330;D000852;D065632;D003715;D008288 | T047;T204 |
36,233,102 | comput qsar molecular dock vitro cytotox studi novel thiouracil base drug anticanc activ human dna topoisomeras ii comput chemistri molecular dock drug design approach combin biochem evalu antitumor activ select deriv thiouracil base dihydroindeno pyrido pyrimidin topoisomeras ii ic cell line includ normal human lung cell line w lung cancer cell line breast cancer cell line mcf cervic cancer hela liver cancer cell line hepg evalu use biochem method global reactiv descriptor physicochem paramet comput show good agreement lipinski veber rule drug criteria molecular dock studi ligand topoisomeras protein provid bind site bind energi deactiv constant inhibit pocket various biochem method use evalu ic cell line qsar model develop colorect cell line hct case studi four qsar statist model predict ic colorect cell line hct correl anticanc activ comput physicochem quantum chemic global reactiv descriptor predict power model indic good correl observ predict activ | D000970;D015179 | T121;T109;T191 |
36,233,101 | ecg marker acut melatonin treatment porcin model acut myocardi ischemia myocardi ischemia melatonin confer antiarrhythm action electrocardiograph express unclear aim evalu effect melatonin treatment electrocardiogram ecg paramet reflect major arrhythmogen factor test associ paramet ventricular fibril vf incid myocardi ischemia induc min coronari arteri occlus anesthet pig induct ischemia anim given melatonin placebo respect twelv lead ecg record durat qrs qt tpeak tend interv extrasystol burden measur baselin occlus ischemia vf episod cluster earli delay phase lt gt min respect qrs durat associ vf incid qt interv extrasystol burden differ group tpeak tend interv progress prolong prolong less pronounc treat anim qrs durat increas demonstr two maxima min respect melatonin group earlier maximum blunt vf develop period prevent thus acut melatonin treatment prevent excess prolong qrs tpeak tend interv porcin myocardi infarct model qrs durat use assess antiarrhythm action melatonin | D008550;D017202 | T121;T047;T109;T125 |
36,233,100 | solubl epoxid hydrolas associ postprandi anxieti decreas healthi adult women metabol bioactiv oxylipin solubl epoxid hydrolas seh play import role inflamm seh may risk modifi various human diseas disord relationship seh risk factor diseas remain elus herein seh protein express activ white blood cell character high fat meal healthi women hw women anorexia nervosa seh express seh activ signific correl increas group two hour consumpt studi meal fast seh express activ posit associ bodi mass index bmi group invers associ age found p valu lt seh associ anxieti depress either group fast timepoint anxieti score decreas eat group higher fast seh associ lower postprandi anxieti decreas hw p valu lt seh character use direct measur verifi relationship protein express vivo activ import oxylipin modul well control food challeng studi design use hw clinic control group women disord eat elucid seh role health adult women | D004851;D054883 | T109;T126;T116 |
36,233,099 | import toll like receptor express monocyt dendrit cell context epstein barr virus infect immunopathogenesi primari glomerulonephr toll like receptor tlr activ unmethyl cytosin phosphat guanosin cpg dinucleotid found genom pathogen epstein barr virus ebv aim studi determin role tlr immunopathogenesi iga nephropathi igan membranoprolif glomerulonephr mpgn context epstein barr virus ebv infect purpos frequenc tlr posit monocyt dendrit cell dcs ie bdca myeloid dendrit cell bdca plasmocytoid dendrit cell studi quantit analysi concentr tlr serum patient diagnos igan mpgn undertaken higher frequenc tlr posit dcs monocyt igan mpgn patient observ compar control group patient diagnos gn exhibit higher percentag bdca cd bdca cd dcs patient control group moreov serum tlr concentr shown signific correl ebv dna copi numberg dna igg igm serum albumin total protein h urin collect test frequenc bdca cd dcs peripher blood find confirm tlr may involv develop igan mpgn | D020031;D005922;D015432;D051217 | T047;T192;T116;T129 |
36,233,098 | first report streptococcus gallolyticus bovi biotyp dsm exopolysaccharid structur streptococcus gallolyticus subspeci gallolyticus known streptococcus bovi biotyp facult pathogen caus bacteraemia infect endocard sepsi link colorect cancer crc correl still unclear bacteri surfac structur major sugar antigen expos outsid microorgan potenti virul factor one primari sugar antigen loos attach cell surfac biofilm compon exopolysaccharid ep epss bovi poor character molecul one macedonicus sc ep structur known entir bovi group gallolyticus dsm ep investig chemic analysi mass spectrometri nuclear magnet reson nmr spectroscopi hexasaccharid repeat unit ep contain four glc two rha residu one phosphat group describ glc p l rha p glc p glc p l rha p glc p p | D016470;D013290 | T047 |
36,233,097 | special issu raman spectroscopi chemic structur character biolog raman spectroscopi popular non invas spectroscop techniqu molecular character imag high spatial resolut | D003952;D013059 | T059;T060;T070 |
36,233,096 | overexpress eucommia ulmoid aquaporin eupip promot leaf growth flower bolt stress toler arabidopsi plasma membran intrins protein pip one largest subfamili aquaporin aqp play import role plant growth develop resist abiot stress studi full length eupip cdna clone eucommia ulmoid use rapid amplif cdna end race method eupip gene induc drought treatment express test tissu highest express level fruit subcellular local show eupip locat plasma membran constitut overexpress eupip arabidopsi thaliana could promot leaf growth develop acceler bolt flower six gene relat growth flower atpif attcp atcri atcri atfca atft signific regul transgen line eupip gene improv resist drought salt stress transgen arabidopsi drought salt stress treatment transgen line higher germin rate accumul osmot substanc lower membran damag could maintain ion homeostasi result suggest eupip play essenti role plant growth develop respons drought salt stress | D020346;D017360;D031283 | T123;T116;T002 |
36,233,095 | novel vivo cometchip reveal ndma induc dna damag repair multipl mous tissu comet assay versatil assay detect dna damag eukaryot cell assay measur level various type damag includ dna strand break abas site alkali sensit site furthermor assay also modifi includ purifi dna glycosylas alkyl oxid base detect cometchip higher throughput version tradit comet assay use studi cultur cell test util studi dna damag present vivo show cometchip effect detect dna damag multipl tissu mice expos direct act methyl agent methylmethan sulfon mms metabol activ methyl agent n nitrosodimethylamin ndma found contamin food water drug specif result mms expos mice demonstr dna damag detect cell liver lung kidney pancrea brain spleen result ndma show dna damag detect metabol compet tissu liver lung kidney dna repair vivo monitor time addit found dna damag persist mani day exposur furthermor glycosylas success incorpor assay reveal presenc damag base overal work demonstr efficaci vivo cometchip reveal new insight format repair dna damag caus mms ndma | D045647;D004128 | T131;T109;T126;T116 |
36,233,094 | magnet micellar nanovehicl prospect multifunct hybrid system precis theranost hybrid nanoarchitectur magnet polymer micell mpms among promis nanotechnolog enabl materi biomed applic combin benefit polymer micell magnet nanoparticl within singl bioinstruct system mpms form self assembl polym amphiphil critic micell concentr generat colloid structur hydrophob core hydrophil shell incorpor magnet particl mnps one segment mpms investig promin contrast agent magnet reson imag mri heat generat hyperthermia treatment magnet suscept nanocarri deliveri releas therapeut agent versatil mpms constitut power rout ultrasensit precis multifunct diagnost therapeut vehicl treatment wide rang patholog although mpms signific explor mri cancer therapi mpms multipurpos function unit widen applic less expect field research bioengin regen medicin herein aim review publish report last five year mpms concern structur fabric method well current foreseen expect advanc biomed applic | D006979;D008823 | T061;T109 |
36,233,093 | recent advanc invert perovskit solar cell design fabric invert perovskit solar cell pscs extens studi reason neglig hysteresi effect easi fabric flexibl pscs good stabil certifi photoelectr convers effici pce achiev owe form lead sulfur pb bond surfac sulfid process perovskit film gradual approach perform tradit upright structur pscs indic industri applic potenti howev fabric devic sever affect moistur high temperatur ultraviolet light due applic organ materi depend nitrogen cost protect may increas especi industri product futur addit invert pscs found seri issu compar tradit upright pscs nonradi recombin carrier inferior stabil cost charg transport materi thus develop invert pscs systemat review paper design fabric charg transport materi perovskit materi enhanc strategi eg interfac modif dope develop inorgan invert devic discuss present indic develop effici stabl invert pscs | D012993 | T070 |
36,233,092 | integr qtl map whole genom sequenc identifi candid gene alkalin toler rice oryza sativa soil alkalin import stressor impair crop growth develop result reduc crop product unlik salin stress research effort understand mechan plant adapt alkalin stress limit rice major stapl food world popul evalu popul recombin inbr line ril develop cross cocodri n alkalin stress seedl stage use linkag map consist snp marker addit qtls identifi seven genom region two qtls multipl trait coloc three import qtl cluster target sever candid gene identifi base high impact variant use whole genom sequenc wgs parent differenti express respons alkalin stress gene includ two express protein gene glucan endo beta glucosidas precursor f box domain contain protein doubl strand rna bind motif contain protein aquaporin protein receptor kinas like protein semialdehyd hydrogenas nad bind domain contain protein gene toler alkalin stress cocodri like due low na k ratio result reduc accumul na ion higher accumul k root shoot studi demonstr util integr qtl map wgs identifi candid gene qtl region qtls candid gene origin toler parent cocodri target introgress improv alkalin toler rice elucid molecular basi alkali toler | D044602;D006864;D012275 | T116;T002;T126;T168;T169 |
36,233,091 | neuron agrin promot prolifer primari human myoblast age depend manner neuron agrin heparan sulphat proteoglycan secret motor neuron promot format mainten neuromuscular junction bind lrp activ muscl specif kinas musk neuron agrin also promot myogenesi enhanc differenti matur myotub effect prolifer human myoblast often consid unrespons agrin remain unclear use primari human myoblast determin neuron agrin induc transient dephosphoryl erk c abl stat focal adhes kinas unrespons gene silenc lrp musk mark reduc brdu incorpor suggest function import lrpmusk complex myoblast prolifer acut chronic treatment neuron agrin increas prolifer human myoblast old donor affect prolifer myoblast young donor c termin fragment agrin lack lrp bind site activ musk similar age depend effect indic age depend signal pathway activ neuron agrin involv lrpmusk receptor complex well lrpmusk independ pathway remain unknown collect result highlight age depend role neuron agrin promot prolifer human myoblast | D000367;D018171;D026502 | T123;T116;T079 |
36,233,090 | moder risk gene hereditari ovarian cancer involv homolog recombin repair pathway approxim case epitheli ovarian cancer eoc hereditari share mani causat gene breast cancer lower frequenc eoc compar breast cancer make challeng estim absolut relat risk verifi efficaci risk reduc surgeri individu harbor germlin pathogen variant gpv eoc predisposit gene particular relat low penetr review molecular featur hereditari tumor risk associ sever moder penetr gene eoc involv homolog recombin repair pathway ie atm brip nbn palb radcd understand molecular mechan under express function gene may elucid trend develop progress hereditari tumor includ eoc fundament understand gene drive eoc help us accur estim genet risk develop eoc select appropri prevent treatment strategi hereditari eoc therefor summar function candid predisposit gene eoc discuss clinic manag individu carri gpv gene | D001943;D010051 | T191 |
36,233,089 | pharmacogenom profil cisplatin resist sensit human osteosarcoma cell line multimod target next generat sequenc cisplatin cddp drug high grade osteosarcoma hgos treatment sever germlin pharmacogenet studi reveal associ singl nucleotid polymorph snps cddp base therapi respons cddp relat toxic patient hgos whether variant could play biolog role hgos cell studi far aim studi explor snps gene cddp resist drug sensit human hgos cell line innov multimod target next generat sequenc mmngs approach custom primer design common report snps gene belong dna repair cddp transport detoxif associ cdpp relat toxic appli mmngs approach valid taqman genotyp assay emerg innov reliabl tool detect genet polymorph dna rna level allel chang three snps ercc rs rs ercc rs identifi dna rna deriv librari associ cddp resist chang gstp rs polymorph aa ag genotyp observ rna six cddp resist variant snps emerg causal associ cddp resist hgos cell | D001859;D012516 | T191 |
36,233,088 | hypoxia regul tumor deriv exosom tumor progress focus immun evas tumor cell express high quantiti exosom packag uniqu cargo hypoxia import characterist featur solid tumor hypox tumor deriv exosom crucial involv interact cancer cell microenviron facilit immun evas increas cell growth surviv enhanc angiogenesi epitheli mesenchym transit emt therapeut resist autophagi pre metastasi metastasi paper explor tumor microenviron tme remodel effect hypox tumor deriv exosom toward facilit tumor progress process particular modulatori role factor tumor cell immun evas suppress immun cell express surfac recognit molecul secret antitumor solubl factor tumor express exosom educ immun effector cell includ macrophag monocyt cell natur killer nk cell dendrit cell dcs lymphocyt regulatori cell treg myeloid deriv suppressor cell mdscs mast cell b cell within hypox tme releas factor regul recruit phenotyp function thus hypoxia tumor deriv exosom modul immun cell growth factor cytokin receptor molecul solubl factor togeth collabor form immun suppress milieu tumor environ explor contribut exosom cargo rnas protein indispens player cross talk within hypox tumor microenvironment provid potenti target antitumor immun subvert immun evas enhanc tumor therapi | D055354;D009369 | T191;T026 |
36,233,087 | need jak inhibitor system lupus erythematosus system lupus erythematosus sle chronic multifactori autoimmun diseas complex pathogenesi character imbal pro inflammatori anti inflammatori cytokin janus kinas jak intracellular non receptor tyrosin kinas essenti signal pathway mani cytokin jak signal transduc activ transcript stat pathway consist four jak kinas seven stat famili member dysregul jak stat pathway repres import process pathogenesi sle thus use therapi target specif signal pathway would challeng sle well known jak inhibitor real potenti treatment rheumat diseas efficaci treatment sle remain determin jak inhibitor current investig phase ii iii trial consid becom next stage sle therapi review report current data regard efficaci jak inhibitor sle develop clinic use kinas inhibitor might improv upon tradit therapeut strategi | D000075242;D008180 | T121;T047 |
36,233,086 | hepatocyt specif defici dax protect mice acetaminophen induc hepatotox activ nrf signal acetaminophen apap wide use analges antipyret drug overdos caus acut liver failur dosag sensit sex revers adren hypoplasia congenita critic region x chromosom gene dax nrb orphan nuclear receptor act transcript co repressor various gene studi identifi role dax apap induc liver injuri use hepatocyt specif dax knockout dax lko mice mous primari hepatocyt use compar vitro studi apap overdos led decreas plasma alanin aminotransferas aspart aminotransferas level dax lko mice compar cblj wt control accompani reduc liver necrosi express gene encod enzym catalyz glutathion gsh synthesi metabol antioxid enzym increas liver apap treat dax lko mice rapid recoveri gsh level mitochondri fraction apap treat dax lko mice led reduc reactiv oxygen speci level result inhibit prolong jnk activ hepatocyt specif dax defici increas protein express nuclear factor erythroid relat factor nrf compar wt control apap administr result indic dax defici hepatocyt protect apap induc liver injuri nrf regul antioxid defens | D058633;D056486;D057137;D051267 | T047;T116;T037;T192;T121;T123;T039 |
36,233,085 | develop two innov perform base object measur felin osteoarthr reliabl respons firocoxib analges treatment metrolog properti two perform base outcom measur felin osteoarthr oa name effort path path stair assay complianc stair test cat natur affect oa n random distribut four group b c mg firocoxibkg bodyweight assess baselin treatment recoveri period path elev walk platform cat land pressur sensit mattress jump onto second elev platform analysi includ veloc time complet peak vertic forc pvf vertic impuls stair number step time complet record step min period reliabl moder good path poor good stair differ normal method describ manuscript placebo group remain stabl within time path wherea treat cat trot faster ramp p lt improv pvf p lt complet task quicker p percentag cat complet stair finish line higher treatment p lt huge effect size placebo group result stabl within time promis perform base outcom measur better diagnos manag felin oa pain | D010003 | T047 |
36,233,084 | mini review molecular interpret igfigf r axi cancer treatment stem cell base therapi regen medicin addit fundament role insulin like growth factor igf igf receptor igf r signal dysregul cancer initi prolifer igfigf r signal also play import role mainten stem cell characterist enhanc stem cell base therapeut efficaci review focus role igfigf r signal preclin igf target therapi includ igf r monoclon antibodi igf r tyrosin kinas inhibitor neutral antibodi igf multipl tumor endocrin disord hand function igfigf r signal stem cell self renew pluripot therapeut efficaci regen medicin outlin final review summar ongo studi igfigf r signal blockad multipl cancer highlight igf r signal modif stem cell potenti strategi improv stem cell base therapeut regen medicin | D009369;D013002 | T191;T116;T125 |
36,233,083 | cancer three dimension spheroid mimic vivo tumor featur display inner extracellular vesicl vasculogen mimicri role extracellular vesicl ev mediat cell cell communic cancer progress wide recogn vitro studi routin perform cultur model recent studi suggest cultur could repres valid model human ovarian cancer cell caba cultur hang drop method form tumor spheroid move low adhes support observ morpholog scan electron microscopi sem isol ev ev releas verifi sem ident confirm morpholog transmiss electron microscopi tem size distribut nanoparticl track analysi marker cd cd tsg calnexin caba form spheroid clinic relev size releas ev extern surfac also trap inner ev also produc vasculogen mimicri like tubul bulg spheroid compos hollow lumen delimit tumor cell caba grown multicellular spheroid easili isol ev presenc featur typic vivo tumor inner entrap ev vasculogen mimicri suggest use faith experiment model screen therapeut drug target pro tumorigen process | D000067128;D010051 | T191;T026 |
36,233,082 | reveal tune photophys cn contain phototherm molecul excit state dynam simul molecular phototherm convers materi recent attract increas attent phototherapi applic herein investig excit de excit process phototherm molecul cti among recent develop class small molecul base phototherm imin superb phototherm convers effici ptces molecul construct replac amino group cti h atom via excit state dynam simul base time depend densiti function theori td dft simul reveal fast lt fs averag time nonradi decay lowest excit singlet state conic intersect ci ground state high yield cti fast decay driven cn bond rotat perpendicular structur configur found barrierless slight structur differ cti lead drastic differ energi surfac especi featur relat much lower ci ev energi much decay energi ev approach ci work provid insight de excit mechan perform tune cn enabl phototherm materi | D007097 | T109 |
36,233,081 | event relat potenti studi recoveri conscious forc awaken slow wave sleep rapid eye movement sleep work aim studi recoveri conscious forc awaken slow wave sleep sws rapid eye movement sleep rem healthi volunt track chang degre awar stimuli transit wake event relat potenti erp motor respons mr auditori local global paradigm analyz result show awaken sws rem first alpha activ restor eeg rem sws awaken respect alpha onset mr target stimuli recov rem awaken alpha rhythm mr conscious awar stimuli recov faster sws awaken moreov pre attent process local irregular emerg earlier even alpha rhythm onset sws awaken local effect regist alpha restor p like respons global local irregular found accur mr restor thus appear eeg predomin alpha activ insuffici either conscious awar extern stimuli generat mr work may help understand pathophysiolog sleep disord well condit character dissoci behavior various aspect conscious | D012895;D000077310 | T042;T039;T041 |
36,233,080 | metabolit content post cultur medium tree fern cyathea delgadii sternb cell suspens cultur presenc bap aim studi demonstr metabol profil post cultur medium express cell suspens metabol activ tree fern cyathea delgadii sternb molecular profil tree fern cell cultur never describ accord knowledg cell suspens establish use ms medium supplement various concentr bap optim concentr mgl mgl respect cell suspens initi show organ system cell divis later unorgan cell prolifer lc ms gc ms use identifi chemic composit post cultur medium lc ms analysi result suggest color liquid medium could due presenc flavonoid deriv group compound repres eight compound gc ms analysi base retent index thank mass spectra comparison natur product recogn belong various class primari secondari metabolit | D001688;D029624;D064028 | T121;T123;T002 |
36,233,079 | therapeut potenti natur occur peptid counteract sh syy cell injuri peptid reveal larg rang biolog activ high select effici develop new drug includ neuroprotect agent therefor work investig neuroprotect properti natur occur peptid endomorphin em endomorphin em rubiscolin r rubiscolin r aim answer question whether well known opioid peptid counteract cell injuri common vitro model parkinson diseas pd antioxid activ four peptid evalu diphenyl picrylhydrazyl radic dpph scaveng activ oxygen radic absorb capac orac ferric reduc antioxid power frap assay neuroprotect effect assess neurotox model induc hydroxydopamin ohda human neuroblastoma cell line sh syy mechan associ neuroprotect investig determin mitochondri membran potenti mmp reactiv oxygen speci ros product caspas activ among test peptid endomorphin signific prevent neuron death induc ohda treatment decreas mmp em caspas activ em meanwhil r show antioxid potenti frap assay exhibit highest capac recov neurotox induc ohda via attenu ros level mitochondri dysfunct general hypothes peptid abil suppress toxic effect induc ohda may mediat differ cellular mechan protect effect caus endomorphin result antiapoptot effect mitochondri protect decreas caspas activ r potenc increas cell viabil seem mediat reduc oxid stress result may provid new insight neurodegener support short peptid potent drug candid treat pd howev studi conduct detail mechan test peptid could suppress neuron injuri | D009447;D018696;D020258;D010300 | T047;T037;T191;T121;T169 |
36,233,078 | pharmacogenet variat clinic relev latin american rural popul latin american popul larg underrepres genom studi drug respons diseas suscept paper present genom wide chilean dataset talca base illumina global screen array let us compar frequenc gene variant involv respons drug among popul other take data genom project found four singl nucleotid polymorph low preval chilean compar african amerindian east south asian european popul rs ryr rs slca rs hla g rs tp moreov two marker show signific differ lower higher proport mapuch ancestri group rs locat intergen region chromosom p valu bonferroni correct p valu rs nonsynonym gene variant pnpla gene p valu bonferroni correct p valu polymorph shown associ divers patholog asthma cancer chronic hepat b involv differ respons drug metformin hmg coa reductas inhibitor simvastatin present work provid pharmacogenet landscap understudi latin american rural popul support notion pharmacogenet studi admix popul consid ancestri higher accuraci result studi stress relev pharmacogenom research provid guidanc better choic best treatment individu popul admix ancestri | D019161;D008687 | T121;T109 |
36,233,077 | sulfon pentablock copolym coat polypropylen filter dye metal ion effect remov integr adsorpt filtrat process work coat polypropylen pp fibrous filter sulfon pentablock copolym pbc layer test remov cation organ dye methylen blue mb heavi metal ion fe co water adsorpt filtrat experi coat filter irradi uv light expos contamin water test unirradi filter adsorpt filtrat experi polym coat filter show high effici remov mb aqueous solut absorpt filtrat process remov respect hand heavi metal ion fe co coat filter show better remov perform filtrat process adsorpt one fact adsorpt process control interact time allow ionic speci interact surfac filter lead format releas new speci solut filtrat ionic speci easili trap filter particular uv modifi filter observ fe ion total remov gt singl filtrat process co ion larger remov respect untreat filter mechan involv remov contamin process investig character filter use mean scan electron microscopi sem combin energi dispers x ray edx analysi fourier transform infrar spectroscopi ft ir | D019216;D014874 | T131;T196 |
36,233,076 | methionin determin factor select inhibit histon deacetylas hdac l shape inhibitor hdac import target sever indic area includ childhood neuroblastoma sever isozym select inhibitor hdac l shape structur develop theoret studi suggest methionin would act switch control transient bind pocket induc upon bind l shape inhibitor hypothesi experiment examin studi thermost function hdac wildtyp mutant variant exchang analyz use biophys method furthermor bind kinet l shape linear refer inhibitor hdac variant determin order elucid mode interact exchang consider impact enzym activ decis factor select recognit hdac l shape inhibitor | D056572;D009447 | T121;T126;T116;T191 |
36,233,075 | hotairmir cav crosstalk influenc prolifer migrat invas breast cancer cell recent year malign breast cancer metastasi caus great increas mortal research genet molecular mechan malign breast cancer continu deepen target therapi becom general trend among compet endogen rna cerna relat molecul receiv much attent homeobox transcript antisens rna hotair report function extens cerna breast cancer notabl mir caveolin cav also found play role breast cancer howev relationship three remain unclear studi present new mechan bioinformat tool basic experi hotair mir cav axi complement role network hotair cerna thus provid novel potenti idea breast cancer research therapi | D001943;D051242;D035683;D062085 | T116;T192;T191;T123;T114 |
36,233,074 | select target breast cancer stem cell quinolinol niclosamid cancer mainten metastat dissemin drug resist sustain cancer stem cell cscs tripl negat breast cancer tnbc breast cancer subtyp highest number cscs poorest prognosi aim identifi potenti drug target cscs employ combin standard chemotherapi tnbc treatment anti csc efficaci small drug test tnbc cell line use cell viabil assay differenti cancer cell cscs effect select drug quinolinol q niclosamid ncs cancer stem featur evalu use mammospher growth cell invas migrat anchorag independ growth assay chang express stem gene q ncs treatment also evalu moreov potenti synerg q ncs ptx csc prolifer stem relat signal pathway evalu use tnbc cell line csc report sublin csc enrich mammospher final efficaci ncs combin ptx analyz vivo use orthotop mous model mda mb cell among test drug candid q ncs show remark specif anti csc activ term csc viabil migrat invas anchorag independ growth reduct vitro moreov specif qptx ncsptx ratio drug display synergist effect differ tnbc cell line identifi sole use ptx increas relat presenc cscs tnbc cell wherea combin q ncs counteract pro csc activ ptx signific reduc cell viabil vivo combin ncs ptx reduc tumor growth limit dissemin diseas reduc circul tumor cell incid lung metastasi combin q ncs ptx establish ratio inhibit prolifer differenti cancer cell viabil cscs pave way efficaci tnbc treatment | D064726 | T191 |
36,233,073 | putat transcript factor gene associ regul carotenoid biosynthesi chili pepper fruit reveal rna seq coexpress analysi ripen process pericarp chili pepper capsicum spp fruit accumul larg amount carotenoid although carotenoid biosynthesi pathway capsicum genus wide studi differ perspect transcript regul gene encod carotenoid biosynthet enzym elucid fruit analyz rna seq transcriptom data fruit access capsicum annuum growth develop ripen process use r packag name salsa perform coexpress analys standard express gene encod carotenoid biosynthet enzym target gene tgs gene express transcript factor tfs addit analyz promot region biosynthet gene identifi putat bind sequenc select tf candid select tfs putat regul carotenogen structur gene putat bind site promot carotenoid biosynthesi relat structur gene found tfs result could guid search transcript factor involv regul carotenogen pathway chili pepper fruit might facilit collect correspond experiment evid corrobor particip regul biosynthet pathway capsicum spp | D002212 | T168;T002 |
36,233,072 | genom wide identif dof gene famili involv fruitlet absciss areca catechu l fruitlet absciss frequent occur areca catechu l caus consider product loss howev induc mechan fruitlet absciss remain mysteri studi observ cell architectur absciss zone az distinct surround tissu vari obvious absciss transcriptom analysi abscis non abscis az perform catechu gene encod plant specif dof dna bind one finger transcript factor show uniform regul az suggest role dof transcript catechu fruitlet absciss total member dof gene famili distribut chromosom identifi catechu genom acdof gene classifi nine subgroup base phylogen analysi six show az specif express pattern express level vari accord absciss process total nine type phytohormon respons cis element five type abiot stress relat cis element identifi promot region acdof gene addit histochem stain show lignin accumul vascular bundl az signific lower pedicel mesocarp indic specif characterist cell architectur az data suggest dof transcript factor might play role fruitlet absciss regul catechu | D018506;D010937 | T045;T116;T125 |
36,233,071 | protect effect rutin triethylen glycol dimethacryl induc toxic inhibit caspas activ reactiv oxygen speci generat macrophag rutin also call quercetin rhamnosyl glucosid natur flavonol glycosid present mani plant rutin use treat various diseas inflamm diabet cancer polymer biomateri triethylen glycol dimethacryl tegdma common use monom serv restor resin dentin bond agent sealant bone cement compon overal tegdma induc various toxic effect macrophag includ cytotox apoptosi genotox aim studi investig protect mechan rutin allevi tegdma induc toxic raw macrophag treatment rutin assess cell viabil apoptosi tegdma induc raw macrophag use methylthiazol tetrazolium mtt assay annexin v fitcpropidium iodid assay respect subsequ assess level genotox use comet micronucleus assay assess cysteinyla aspart specif proteinas caspas antioxid enzym aoe activ use commerci kit evalu generat reactiv oxygen speci ros use dichlorodihydrofluorescein diacet dcfh da assay evalu express heme oxygenas ho express nuclear factor erythroid relat factor nrf phosphoryl amp activ protein kinas ampk use western blot assay result indic rutin substanti reduc level cytotox apoptosi genotox tegdma induc raw macrophag rutin also block activ caspas caspas caspas tegdma stimul raw macrophag addit decreas tegdma induc ros generat aoe deactiv macrophag final found tegdma inhibit slight ho express nrf express ampk phosphoryl would rever rutin addit ho express nrf express ampk phosphoryl enhanc rutin find indic rutin suppress tegdma induc caspas mediat toxic effect ros generat antioxid system deactiv nrf ampk pathway therefor rutin potenti serv novel antitox agent tegdma raw macrophag | D055372;D012431 | T121;T109;T126;T116 |
36,233,070 | exfoli reassembl rout geruo nanocomposit anod advanc lithium ion batteri geruo nanocomposit success fabric anod materi lithium ion batteri use ruo nanosheet gegeo nanoparticl nps x ray diffract xrd x ray absorpt spectroscopi xas analys show element ge nanoparticl distribut onto rutil type ruo transmiss electron microscopi imag show well dispers ge nanoparticl embed rutil type ruo geruo nanocomposit maintain higher discharg capac h g th cycl g h g gegeo nanoparticl geruo nanocomposit exhibit higher capac retent gegeo nps result suggest well dispers ge nanoparticl within ruo matric enhanc cycl stabil capac retent anod materi | D008094;D053761 | T121;T196;T073 |
36,233,069 | driman sesquiterpen aldehyd control candida yeast isol candidemia chilean patient drimi winteri jr winteracea produc driman sesquiterpenoid activ candida yeast work drimenol polygodi isotadeon new driman unsatur dialdehyd name winterdi purifi bark winteri oxid drimenol produc monoaldehyd drimen four aldehyd sesquiterpenoid evalu six candida speci isol candidemia patient chilean hospit result show display fungistat activ yeast gml irrit effect eye skin wherea non pungent epim fungistat fungicid activ gml respect hand compound less activ molecular dynam simul suggest compound capabl bind catalyt pocket lanosterol alpha demethylas similar bind free energi thus suggest potenti mechan action inhibit ergosterol synthesi accord find compound appear valuabl molecular scaffold pursu futur develop potent drug candidiasi fewer side effect polygodi outcom signific broaden altern treat fungal infect increas preval worldwid use natur compound primari sourc activ compound | D058387;D005659;D012717 | T047;T109;T131 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.