PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,233,068 | select calpain inhibit improv function histopatholog outcom canin spinal cord injuri model calpain activ implic various patholog includ neurodegener thus calpain inhibit could effect prevent spinal cord injuri sci associ neurodegener current studi dog sci model use evalu therapeut potenti select calpain inhibitor pd combin methylprednisolon sodium succin mpss anti inflammatori drug sci experiment induc sixteen mongrel dog epidur balloon compress techniqu dog alloc random four group control mpss pd mpsspd clinic evalu serum biochem somatosensori evok potenti histopatholog immunoblot analys perform assess treat dog studi current find reveal combin administr mpsspd demonstr consider lower neuron loss microgli cell infiltr group signific improv locomotor score increas level inflammatori marker gfap cd calcium bind protein iba signific reduc combin group lesser extent mpss pd treatment alon interest combin treatment effect inhibit calpain induc cleavag p limit cdk activ inhibit tau phosphoryl result suggest earli mpsspd therapi acut sci may prevent subsequ neurodegener via calpain inhibit | D008776;D013119 | T121;T109;T037;T125 |
36,233,067 | osnac regul toler zinc defici cadmium bind oszip oszip rice zinc zn defici cadmium cd stress sever threat growth develop plant increas zn content andor decreas cd content grain also import object rice breed howev molecular mechan zn defici toler zdt cd stress toler cdt larg unknown rice report namcuc like transcript factor osnac contribut zdt cdt rice knockout osnac reduc zdt cdt veget stage osnac express tissu differ development stage repress zn defici induc cd stress osnac function transcript factor transactiv dna bind activ express analysi rice zip famili gene suggest knockout osnac activ inhibit transcript zn defici cd stress condit yeast one hybrid assay transient transcript activ assay use dual luciferas report system electrophoret mobil shift assay demonstr osnac direct bind zinc defici respons element motif promot oszip oszip repress transcript osnac oszip modul essenti foundat studi regulatori mechan zdt cdt rice | D002104;D012275 | T131;T002;T196;T168 |
36,233,066 | therapeut approach age relat macular degener damag retin pigment epithelium bruch membran andor tissu under macula known increas risk age relat macular degener amd amd common categor two distinct type name nonexud dri form exud wet form current ideal treatment avail amd recommend standard treatment base use vascular endotheli growth factor vegf disadvantag requir repeat intravitr inject hinder patient complianc therapi recent year sever synthet natur activ compound propos innov therapeut strategi diseas grow interest develop formul base nanotechnolog import role manag posterior eye segment disord without use intravitr inject furthermor potenti prolong drug releas thus reduc advers effect way bioprint constitut altern regener therapi human retina restor function applic bioprint may chang current futur perspect treatment patient amd especi respond convent treatment monitor progress amd treatment diseas retin imag use work revis recent challeng encount treatment differ form amd innov nanoformul bioprint techniqu monitor progress | D008266;D008268 | T023;T047 |
36,233,065 | enhanc bdnf trkb activ enhanc gaba neurotransmiss cerebellum hyperammonemia hyperammonemia main contributor minim hepat encephalopathi mhe cirrhot patient hyperammonem rat reproduc motor incoordin mhe patient due enhanc gabaerg neurotransmiss cerebellum consequ neuroinflamm hyperammonem rat neuroinflamm increas bdnf activ tnfr spr ccr pathway identifi mechan enhanc gabaerg neurotransmiss hyperammonemia assess role enhanc activ trkb assess role tnfr spr ccr bdnf pathway cerebellum hyperammonem rat increas bdnf level enhanc trkb activ purkinj neuron lead increas gad gad gaba level enhanc trkb activ also increas membran express subunit gaba receptor kcc moreov enhanc trkb activ activ astrocyt increas membran express gat nkcc chang revers block trkb tnfr sppr ccl ccr bdnf trkb pathway hyperammonemia induc neuroinflamm increas bdnf trkb activ lead increas synthesi extracellular gaba amount gaba receptor membran chlorid gradient factor enhanc gabaerg neurotransmiss cerebellum block trkb tnfr sppr ccl ccr bdnf trkb pathway would improv motor function patient hepat encephalopathi like patholog associ neuroinflamm | D019208;D006501;D022124;D020813;D027981 | T047;T116;T192;T126;T123 |
36,233,064 | mechan cd induc cytotox normal human skin keratinocyt implic human health cadmium cd one toxic heavi metal found wide environ skin import target organ cd exposur howev advers effect cd human skin still well known studi normal human skin keratinocyt hacat cell studi chang cell viabil morpholog dna damag cycl apoptosi express endoplasm reticulum er stress relat gene xbp bip atf chop exposur cd h found cd decreas cell viabil concentr depend manner median lethal concentr lc dna damag induct evidenc upregul level hax furthermor cd induc gg phase cell cycl arrest apoptosi dose depend manner upregul mrna level er stress biomark gene xbp bip atf chop taken togeth result show cd induc cytotox dna damag hacat cell eventu result cell cycl arrest gg phase apoptosi addit er stress may involv cd induc hacat apoptosi data impli import reduc cd pollut environ reduc advers impact human skin | D002104;D059865 | T131;T196;T049 |
36,233,063 | rybp sensit cancer cell parp inhibitor regul atm activ ring yy bind protein rybp member non canon polycomb repress complex prc like prc member best describ transcript regul previous show rybp along prc member also involv dna damag respons rybp inhibit recruit breast cancer gene brca complex dna damag site bind k link ubiquitin chain addit ataxia telangiectasia mutat atm kinas serv import sensor kinas earli stage dna damag respons report overexpress rybp result inhibit atm activ recruit dna damag site cell express rybp show less phosphoryl atm substrat chk dna damag due abil inhibit atm activ find rybp sensit cancer cell poli adp ribos polymeras parp inhibitor although find synergist effect parp inhibitor atm inhibitor cancer cell synergi lost cell express rybp also show overexpress rybp hinder cancer cell migrat least part atm inhibit provid new mechan rybp express may sensit cancer cell dna damag agent inhibit cancer metastasi | D064007;D009369;D000067856;D012097 | T116;T191;T121;T126;T123 |
36,233,062 | aplast anemia roadmap bone marrow failur overview clinic workflow recent year becom increas appar bone marrow bm failur myeloid malign predisposit syndrom character wide phenotyp spectrum diseas must consid differenti diagnosi children adult unexplain hematopoiesi defect clinic hypocellular bm failur still repres challeng pathobiolog guid treatment three fundament topic emerg review exist data exogen stressor immun defect constitut genet defect fuel vicious cycl hematopoiet stem cell immun nich stroma compart wide phenotyp spectrum exist inherit acquir bm failur predisposit myeloid malign order effect manag patient crucial establish right diagnosi new theragnost window reveal explor bm failur pathomechan | D000741;D001855;D010198 | T047 |
36,233,061 | cardiolipin enhanc cellular uptak cytotox thermosensit liposom encapsul daunorubicin toward breast cancer cell line daunorubicin dnr cardiolipin cl co deliv use thermosensit liposom tsls dipalmitoyl sn glycero phosphocholin dppc myristoyl stearoyl sn glycero phosphocholin mspc cholesterol distearoyl sn glycero phosphoethanolamin n methoxi polyethylen glycol dspe mpeg cl use formul liposom molar ratio respect cl form raft like microdomain may reloc chang lipid organ outer inner mitochondri membran transbilay lipid movement eventu lead membran permeabil tsls prepar thin film hydrat drug lipid ratio dnr encapsul within aqueous core liposom cl act compon lipid bilay liposom exhibit high drug encapsul effici gt small size nm narrow size distribut polydispers index rapid releas profil influenc mild hyperthermia liposom also exhibit fold higher cytotox mda mb cell compar dnr liposom similar daunoxom p lt studi provid basi develop co deliveri system dnr cl encapsul liposom treatment breast cancer | D001943;D008081 | T191;T109 |
36,233,060 | ncapg promot pulmonari arteri smooth muscl cell prolifer promis therapeut target idiopath pulmonari hypertens bioinformat analysi experi verif idiopath pulmonari arteri hypertens ipah diseas complex etiolog current ipah treatment limit patient prognosi poor studi aim explor new therapeut target ipah bioinformat two data set gse gse meet requir obtain gene express omnibus geo databas differenti express gene deg identifi analyz networkanalyst platform enrich gene ontolog go kyoto encyclopedia gene genom kegg examin function deg protein protein interact ppi network construct identifi central gene use cytonca plug final four central gene aspm cenp ncapg topa screen select ncapg protein level verif establish anim model pah found express ncapg signific increas lung tissu pah rat vitro experi show express ncapg signific increas prolif pulmonari arteri smooth muscl cell pasmc ncapg pasmc knock cell prolifer inhibit suggest ncapg relat prolifer pasmc therefor result may provid new therapeut target ipah | D018797;D032389;D000081029 | T025;T123;T116;T047 |
36,233,059 | inhibit high temperatur requir protein proteas activ repress myogen differenti via uprmt skelet muscl requir muscl satellit cell musc differenti facilit replenish repair muscl fiber key step process call myogen differenti differenti abil musc decreas age result sarcopenia although mitochondria report involv myogen differenti promot bioenerget remodel littl known interplay mitochondri proteostasi myogen differenti high temperatur requir protein htraomi proteas regul proteostasi mitochondri intermembran space im mice defici htra proteas activ show distinct phenotyp sarcopenia investig role im proteostasi myogen differenti treat cc myoblast ucf specif inhibitor htra differenti process key step process call myogen differenti differenti abil musc decreas age result sarcopenia chop p eif mitochondri unfold protein respons uprmt relat protein upregul therefor suggest imbal mitochondri im proteostasi act via retrograd signal pathway inhibit myogen differenti via uprmt pathway novel mechanist insight may implic develop new strategi treatment sarcopenia | D000074923;D024101;D055948 | T047;T126;T116;T123 |
36,233,058 | role small heat shock protein protein misfold associ motoneuron diseas motoneuron diseas mnds neurodegen condit associ death upper andor lower motoneuron mns proteostasi alter pathogen mechan involv mani mnds due excess presenc misfold aggreg protein protein misfold may product gene mutat due defect translat process stress agent condit may alter nativ conform protein make prone aggreg altern mutat member protein qualiti control pqc system may determin loss function proteostasi network caus impair capabl handl remov aberr damag protein pqc system consist degrad pathway autophagi proteasom network chaperon co chaperon among compon heat shock protein repres main factor substrat triag fold refold degrad assist task subclass chaperon network small heat shock protein shspshspbs famili hspbs take part proteostasi bridg misfold aggreg protein hsp machineri degrad pathway facilit refold clearanc potenti toxic protein activ proteostasi alter chaperon system play relev role protect proteotox mnds discuss role hspbs mnds hspbs may repres valid target therapeut purpos | D050888;D016472;D057165 | T047;T123;T116;T049 |
36,233,057 | cxcr cxcr cd may involv home lymphoma cell eye patient deriv xenograft home mous model primari vitreoretin lymphoma primari vitreoretin lymphoma pvrl rare malign eye strong relat primari central nervous system lymphoma pcnsl hypothes lymphoma cell dissemin cns eye tissu via distinct home receptor object studi test express cxcr cxcr cxcr cd home receptor cd posit b lymphoma cell enucl eye use pcnsl xenograft mous model | D016543;D008223;D019572 | T191 |
36,233,056 | gut microbiota restor central neuropeptid deficit germ free mice recent work demonstr abil gut microbiota gm alter express releas gut peptid control appetit regul energi homeostasi howev littl known neuron respons hormon germ free gf anim especi leptin strike low anim therefor aim determin respons exogen leptin gf mice compar convent rais conv r mice specif inject measur serum leptin gf conv r mice measur express orexigen anorexigen peptid npi agrp pomc cart hypothalamus hindbrain examin whether gm impact central nervous system regul energi homeostasi found gf mice signific increas hypothalam npi agrp mrna express decreas hindbrain npi agrp mrna mrna express pomc cart remain unchang administr leptin normal circul level leptin glp pyy ghrelin signific decreas gf mice final brief convention gf mice day restor deficit hypothalam hindbrain neuropeptid present gf anim taken togeth result show gm regul hypothalam hindbrain orexigenicanorexigen neuropeptid express line role gut microbiota lipid metabol fat deposit may contribut excess fat convention anim high feed condit | D000069196;D009479 | T007;T001;T123;T116 |
36,233,055 | de novo transcriptom analysi reveal flower relat gene potenti contribut flower time control japanes cultiv gentian gentiana triflora japanes cultiv gentian perenni plant flower earli summer late autumn japan depend cultivar sever flower relat gene includ gt ft gt tfl known involv regul flower time mani gene remain unidentifi studi obtain transcriptom profil data use gentiana triflora cultivar maciri typic flower late juli conduct deep rna sequenc analysi use gentian plant grown natur field condit three month flower investig diurnal chang plant sampl h interv h use transcriptom data determin express profil leav base homolog search flower interact databas arabidopsi particular focus transcript factor gene belong bbx mad box famili analyz development diurnal variat express level repres bbx gene also analyz long short day condit use vitro grown seedl express pattern bbx gene differ cluster analysi reveal transcript factor gene coexpress gt ft overal express profil facilit analysi molecular mechan under control flower time gentian | D035264;D030012 | T002 |
36,233,054 | monoamin oxidas inhibitor prevent glucos depend energi product prolifer migrat bladder carcinoma cell bladder cancer th common cancer world high risk recurr metastasi order sustain high energet need cancer cell undergo complex metabol adapt switch toward aerob glycolysi exploit therapeut reactiv oxygen speci ros act key regul cancer metabol reprogram tumorigenesi sourc ros remain unidentifi monoamin oxidas mao mitochondri enzym generat h breakdown catecholamin serotonin enzym particular import neurolog disord recent new link mao cancer uncov involv product ros present putat role mao bladder cancer never evalu observ human urotheli tumor explant bladder cancer cell line ay express mao mao b isoform select inhibit mao mao b limit mitochondri ros accumul cell cycl progress prolifer bladder cancer cell mao inhibit prevent cell motil test whether ros contribut mao induc tumorigenesi use mutat form mao unabl produc h adenovir transduct wt mao stimul prolifer migrat ay cell lysmet mao mutant inact consist fact antioxid trolox strong impair prolifer cell cycl progress interest ay cell high depend glucos metabol sustain growth mao inhibitor potent reduc glycolysi oxid phosphoryl due pyruv deplet accord mao inhibitor decreas express protein involv glucos transport glut transform hk conclus urotheli cancer cell character metabol shift toward glucos depend metabol import cell growth regul mao depend oxid stress | D002277;D001749 | T191 |
36,233,053 | tale two lobster transcriptom analysi reveal potenti gap rna interfer pathway tropic rock lobster panulirus ornatus rna interfer rnai wide utilis mani invertebr model sinc discoveri major instanc present high effici potent gene silenc mechan emphas crustacean almost taxa capac trigger effect silenc notabl except spini lobster repeat attempt dsrna induc rnai demonstr extrem ineffect gene knockdown comparison core rnai machineri transcriptom data spini lobster panulirus ornatus close relat slipper lobster thenus australiensi silenc high effect reveal lobster possess protein involv small interf microrna pathway littl differ sequenc domain architectur level compar express gene howev demonstr australiensi signific higher express transcript encod protein direct interact dsrna compar p ornatus valid via qpcr result suggest low express core rnai gene may hinder silenc respons p ornatus suggest may critic enhanc express gene induc effici silenc spini lobster | D033364;D035683;D033521 | T123;T114;T204 |
36,233,052 | physiolog base pharmacokinet model predict impact metabol chang associ metabol associ fatti liver diseas drug exposur metabol associ fatti liver diseas mafld common chronic liver diseas estim preval worldwid observ data support vitro pre clinic anim model mafld suggest meaning differ drug disposit mafld patient studi aim build physiolog base pharmacokinet pbpk model reflect observ chang physiolog molecular paramet relev drug disposit associ mafld comprehens literatur review meta analysi conduct identifi studi describ vivo physiolog chang along vitro pre clinic model chang cyp c c protein abund associ mafld mafld popul profil construct simcyp version adapt demograph physiolog covari sim healthi popul profil base meta analysi observ data publish literatur simul demonstr singl dose steadi state area plasma concentr time curv auc caffein clozapin omeprazol metoprolol dextromethorphan midazolam warfarin rosiglitazon increas gt mafld popul compar healthi control popul find indic mafld patient like experi meaning higher exposur drug primarili metabol cyp c cypc closer monitor mafld patient use drug primarili clear cyp c warrant reduc metabol activ increas drug exposur like result increas incid toxic popul | D003024;D065626 | T121;T047;T109 |
36,233,051 | comprehens analysi anti cancer activ quercetin ros mediat cancer cancer stem cell reactiv oxygen speci ros induc carcinogenesi caus genet mutat activ oncogen increas oxid stress affect cell prolifer surviv apoptosi compar normal cell cancer cell higher level ros respons mainten cancer phenotyp uniqu featur cancer cell may therefor exploit target therapi quercetin qc plant deriv bioflavonoid known ros scaveng properti recent discov various antitumor properti varieti solid tumor adapt stress respons may induc persist ros stress allow cancer cell surviv high level ros maintain cellular viabil howev larg amount ros make cancer cell extrem suscept quercetin one avail dietari flavonoid molecular metabol distinct malign normal cell target ros metabol might help overcom medic resist achiev therapeut select littl effect normal cell power bioactiv modulatori role quercetin prompt extens research chemic identifi number pathway potenti work togeth prevent cancer alongsid qc great number evid use therapeut agent cancer stem cell current studi broad demonstr function mechanist relationship quercetin regul ros generat kill cancer cancer stem cell reveal regul product ros normal cell cancer cell certain signal mechan demonstr specif molecular mechan quercetin includ mapkerk p jakstat trail ampkaskp ragepikaktmtor axi hmgb nf b nrf induc signal pathway certain cell cycl arrest cancer cell death regul specif cancer signal pathway long search cancer therapeut | D024243;D009369 | T191;T123;T116 |
36,233,050 | common variant cdk gene associ sporad pituitari adenoma portugues popul case control studi major pituitari adenoma occur sporad context absenc known genet predisposit three common variant nebl rs pcdh rs cdk rs loci previous associ sporad pituitari adenoma han chines popul find yet replic popul aim case control studi assess variant associ suscept sporad pituitari adenoma portugues popul genotyp allel frequenc determin case control cdk rs minor allel allel signific associ sporad pituitari adenoma addit odd ratio confid interv ci p domin ci p inherit model nebl rs pcdh rs variant associ overal risk diseas although borderlin signific associ observ pcdh rs minor allel allel somatotrophinoma domin model ci p find suggest cdk rs variant possibl pcdh rs variant may increas suscept sporad pituitari adenoma portugues popul | D000236;D056850;D010911 | T191;T126;T116 |
36,233,049 | solut studi pharmaceut aspirin relat compound thermodynam aspirin cyclodextrin interact water n n dimethylformamid solut behavior pharmaceut acetylsalicyl acid acetoxybenzo acid acetylsalicyl acid water n n dimethylformamid dmf k investig solubl conduct calorimetr measur take account format ion pair pharmaceut water solut gibb energi dissoci electrolyt solvent calcul thus solut thermodynam compound water report use enthalpi data obtain calorimetri pharmaceut undergo solvat expos satur atmospher dmf composit solid solut gibb energi solut compound could obtain enthalpi data report thermodynam interact acetylsalicyl acid aspirin cyclodextrin water dmf fulli discuss emphas two differ process take place water two differ phs case favor gibb energi process entrop control main result higher dehydrationdesolv receptor undergo upon interact guest | D014867;D047392 | T121;T109;T197 |
36,233,048 | celiac diseas possibl dietari intervent enzym probiot postbiot virus celiac diseas ced chronic small intestin immun mediat enteropathi caus ingest dietari gluten protein genet suscept individu ced one common autoimmun diseas affect around popul global date accept treatment ced strict lifelong adher gluten free diet gfd howev case gfd alter gluten induc symptom addit strict adher gfd reduc patient qualiti life often socio econom burden narrat review offer interdisciplinari overview ced pathomechan limit gfd focus current research possibl dietari intervent concentr recent research degrad gluten enzym modul microbiom differ type biotic strategi probiot less explor viromebiot possibl benefici complementari intervent ced manag final aim set context futur research may consid role gluten protein microbiom nutrit non pharmacolog intervent ced beyond sole use gfd | D002446;D019936;D014780 | T007;T047;T005 |
36,233,047 | augment cpta express associ prolifer coloni format barrett tumorigenesi obes known risk factor develop gastroesophag reflux diseas gerd barrett esophagus progress esophag adenocarcinoma mechan obes contribut gerd progress current well understood recent chang lipid metabol especi context high fat diet link gerd lead us explor whether fatti acid oxid play role diseas progress gerd esophag adenocarcinoma end analyz express rate limit enzym carnitin palmytoyltransferas cpta human tissu cell line repres differ stage sequenc normal squamous esophagus cancer determin uptak palmit acid abund fatti acid human serum fluoresc dye label lipid well function consequ stimul palmit acid relev barrett tumorigenesi eg prolifer characterist stem il mediat inflammatori signal employ differ mous model includ genet model barrett esophagus base il overexpress presenc absenc high fat diet deoxychol acid physiolog mimic gastrointestin reflux mice togeth data demonstr cpta upregul barrett tumorigenesi experiment palmit acid deliv mitochondria associ increas cell prolifer stem cell marker express | D000230;D001471;D002334;D004938;D005764 | T191;T047;T126;T116 |
36,233,046 | molecular pathway involv lrrk link parkinson diseas systemat review parkinson diseas one common neurodegen diseas affect age popul preval doubl last year mechan diseas fulli elucid current treatment unabl effect prevent neurodegener studi found mutat leucin rich repeat kinas lrrk common caus famili parkinson diseas pd moreov aberr higher lrrk kinas activ influenc idiopath pd well henc aim review categor synthes current inform relat lrrk link pd present factor associ lrrk target therapeut systemat review conduct use databas pubm medlin scopus sage cochran januari juli search term includ parkinson diseas mechan lrrk synonym various combin search yield total abstract initi review met inclus criteria emphas molecular mechan reveal recent vivo vitro studi consolid recent updat field lrrk link pd research evalu target therapeut applic | D019636;D010300 | T047 |
36,233,045 | two synthet peptid correspond human follicl stimul hormon subunit promot reproduct function mice follicl stimul hormon fsh wide use assist reproduct synthet peptid correspond receptor bind region human h fsh trdl modul reproduct furthermor amino acid sequenc correspond hfsh lvykdparpkiqk recent identifi receptor bind site hypothes synthet peptid correspond hfsh hfsh creat merg hfsh hfsh modul reproduct function longer peptid biolog activ male femal prepubert mice singl inject gg bw ip hfsh hfsh hasten p lt puberti wherea treatment given daili promot p lt gonad steroidogenesi gamet format addit either peptid vitro cell cultur promot p lt prolifer primari murin granulosa cell estradiol product upregul express ccnd cypa respect adult femal mice gg bw ip either peptid diestrus antagon fsh stimul estradiol increas uterin weight gain proestrus furthermor hfsh potent p lt reproduct modul hfsh vivo vitro conclud hfsh especi hfsh potenti reproduct modul | D043373;D037201 | T121;T116;T125 |
36,233,044 | combin machin learn analyt correl establish quantit complianc trolox equival antioxid capac valu obtain via electron paramagnet reson ultraviolet visibl spectroscopi recent interest antioxid capac food beverag base establish medic knowledg antioxid play essenti role counteract damag effect free radic prevent human neurodegen diseas cardiovascular disord even cancer time method uniqu defin antioxid capac substanc moreov question interrel result obtain differ experiment techniqu still open work consid trolox equival antioxid capac teac valu obtain electron paramagnet reson epr spectroscopi ultraviolet visibl uv vis spectroscopi use classic object studi exampl red ros white wine sampl base entir differ physic principl two method give valu simpli interrel creat demand machin learn suitabl tool reveal quantit correspond consider consist approxim correl base analyt model key argument ie teacepr subsequ adjust machin learn base process util catboost algorithm usag auxiliari chemic data total phenol content color index accur describ analyt express | D000975;D002839 | T121;T109;T123;T044;T039 |
36,233,043 | raman metabolom candida auri clade profil barcod identif studi target siter time taxonom identif metabol profil seven differ candida auri cladessubclad mean raman spectroscopi imag repres raman spectra differ candida auri sampl systemat deconvolut mean custom machin learn algorithm link raman databas order decod structur differ molecular scale raman analys metabolit reveal clear differ cell wall membran structur among cladessubclad differ key maintain integr physic strength cell wall dynam respons extern stress drug found candida cell use glucan structur extracellular matrix degre chitin crystallin concentr hydrogen bond antiparallel chain tailor cell wall flexibl besid effect ploy survivorship provid stiff shield glucan polymorph glycosid linkag also water insolubl thus form rigid hydrophob scaffold surround matrix pliabl hydrat glucan raman analysi reveal varieti strategi differ clade balanc stiff hydrophob imperm cell wall select strategi lead differ resist toward specif environment stress cationicosmot oxid nitros origin statist valid base princip compon analysi found partial capabl distinguish among raman spectra clade subclad raman barcod base algorithm convert spectral deconvolut raman sub band barcod allow circumv speciat defici empow barcod bioinformat raman analys fast requir sampl prepar allow site speciat real time select appropri treatment | D002177;D047071 | T121;T047;T109 |
36,233,042 | effect nri abcb genet polymorph everolimus pharmacokinet japanes renal transplant patient purpos studi evalu effect nri g gt c gt abcb c gt g gt ta c gt genet polymorph everolimus pharmacokinet japanes renal transplant patient day everolimus administr blood sampl collect prior h administr dose adjust area blood concentr time curv auc everolimus signific lower patient nri cc genotyp genotyp p signific higher male patient femal patient p signific correl dose adjust auc everolimus age p aspart transaminas p alanin transaminas p found multivari analysi age p higher alanin transaminas level p independ predict higher dose adjust everolimus auc age hepat dysfunct patient may need consid evalu dose reduct everolimus renal transplant patient manag use everolimus blood concentr administr may import analysi nri c gt polymorph administr | D018435;D000068338;D016030;D000077297 | T116;T192;T061;T121;T109;T123 |
36,233,041 | interior hotspot engin ag au bimetal nanocomposit situ galvan replac reaction rapid sensit surfac enhanc raman spectroscopi detect engin interior hotspot provid paradigm shift tradit surfac enhanc raman spectroscopi ser detect sensit depend posit adsorb molecul present work develop ag au bimetal nanocomposit sgbmnc ser platform interior hotspot facil chemic synthes ag nanoparticl replac au via galvan replac reaction grr provid hotspot region insid sgbmnc remark enhanc plasmon activ compar convent ser platform without intern hotspot diffus analyt propos interior hotspot grr process enabl sensit detect within ser behavior sgbmnc platform investig use methylen blue mb raman probe dye quantit studi reveal excel detect perform limit detect lod pm mb dye high linear correl peak intens concentr r sgbmnc platform also enabl detect toxic benzyl butyl phthalat suffici lod ppb ie pm therefor believ propos methodolog use ser assay hazard materi practic field | D053768;D053761 | T073 |
36,233,040 | cytokin storm definit caus implic human innat adapt immun system consist effector cell produc cytokin interleukin interferon chemokin numer mediat usual fragil equilibrium pro anti inflamm effect maintain complex regulatori mechan disturb homeostasi lead intric chain reaction result massiv releas cytokin may result drastic self reinforc various feedback mechan ultim lead system damag multi organ failur death pathogen initi disturb also congenit diseas immunomodulatori therapi due complex divers interact within innat adapt immun system understand import clinic syndrom incomplet date effect therapeut approach remain scarc | D000080424;D016207 | T047;T116;T129 |
36,233,039 | epigenet neuron activ marker suggest recruit prefront cortex hippocampus three hit model depress male pacap heterozyg mice depress increas preval challeng patient healthcar system economi recent creat mous model base three hit concept depress genet predisposit first hit appli pituitari adenyl cyclas activ polypeptid heterozyg mice cd background matern depriv model epigenet factor second hit chronic variabl mild stress environment factor third hit fluoxetin treatment appli test predict valid model aim examin dynam epigenet marker acetyl lysin h histon hkac neuron activ marker fosb prefront cortex pfc hippocampus fluoxetin decreas hkac pfc non depriv anim histori matern depriv abolish effect stress ssri treatment hkac immunoreact hippocampus stress decreas ssri increas hkac immunosign unlik depriv mice opposit effect detect fosb stress stimul fluoxetin pfc inhibit hippocampus fosb immunoreact almost complet abolish hippocampus depriv mice studi show fosb hkac modul territori specif manner earli life advers later life stress interact effect fluoxetin therapi support reliabl model | D005473;D051219 | T121;T109;T123;T116 |
36,233,038 | anti inflammatori analges effect curcumin nanoparticl associ diclofenac sodium experiment acut inflamm present studi evalu anti inflammatori analges effect convent curcumin cc curcumin nanoparticl nc associ diclofenac sodium experiment acut inflamm ai induc carrageenan administr seven group eight random select wistar bratislava white rat evalu one group control c ai induc six group ai group treat salin solut aid group treat aicc ainc group treat cc nc respect aiccd aincd treat cc nc respect associ convent curcumin nc administ singl dose mgkg bw cc nc mgkg bw associ cc nc result signific antinocicept activ improv mechan pressur stimul heat threshold h p lt associ cc nc aiccd aincd group show signific lower plasma tissu level tumor necrosi factor tnf interleukin il interleukin il time best result group receiv nc moreov aincd present least sever histopatholog chang reduc level inflamm dermi hypodermi combin nc show effici reduc pain inflammatori cytokin histolog chang acut inflamm | D003474;D053758 | T121;T109;T073;T130 |
36,233,037 | applic cellulos acet membran separ ferment broth revers osmosi feasibl studi recent special research focus bioconvers glycerol propanediol pd due signific chemic industri howev treatment separ ferment broth great challeng current revers osmosi ro process reliabl state art techniqu separ biolog solut studi first investig feasibl separ pd broth use cellulos acet ca membran ro process experi carri use instal equip plate modul transmembran pressur tmp temperatur mpa k respect found use membran suitabl broth separ inde note pd target product migrat membran meanwhil broth compon reject various degre moreov proven retent carboxyl acid tend increas increas molecular weight accord follow order succin acid gt lactic acid gt acet acid gt formic acid regard ion retent degre increas increas ionic radius decreas diffus coeffici final demonstr ca membran resist irrevers foul posit effect econom viabil process | D008567;D018508 | T074;T057;T052 |
36,233,036 | quantif farnesyl progerin hutchinson gilford progeria patient cell mass spectrometri hutchinson gilford progeria syndrom hgps rare fatal disord character prematur age death median age year common caus hgps affect circa patient de novo heterozyg synonym singl base substitut cc gt pgg lmna gene result accumul progerin aberr form lamin unlik matur lamin remain perman farnesyl ratio progerin matur lamin correl diseas sever hgps patient use assess effect therapi aim lessen aberr splice progerin farnesyl recent show endogen content lamin progerin measur mass spectrometri ms provid altern immunolog method lack necessari specif quantit accuraci present first non immunolog method reliabl quantifi level wild type lamin farnesyl progerin cell hgps patient method base target ms approach use isotop label intern standard could appli ongo clinic trial evalu efficaci drug inhibit progerin farnesyl | D011371 | T047 |
36,233,035 | cell free dna prognost biomark monitor muscl invas bladder cancer cell free dna cfdna recent emerg real time biomark diagnosi monitor predict therapi respons tumor diseas evalu cfdna prognost biomark monitor muscl invas bladder cancer mibc patient differ follow time point blood sampl mibc patient underw radic cystectomi rc collect cystectomi month later plasma cfdna amount fragment pattern determin four mutat analyz cfdna detect circul tumor dna ctdna patient follow median follow month patient progress median time progress month cfdna level ctdna status four month rc identifi independ prognost biomark tumor progress hr p cancer specif surviv hr p respect furthermor ctdna clearanc four month rc signific associ patient clinic outcom conclus cfdna level ctdna status four month rc prognost implic mibc patient addit cfdna monitor use predict patient outcom rc cfdna analysi clinic set could great improv mibc patient manag | D000073888;D000074141;D001749 | T191;T123;T114 |
36,233,034 | experiment clinic biomark progress evalu neuropatholog therapeut intervent acut chronic neurolog disord articl describ common use experiment clinic biomark neuron injuri neurodegener evalu neuropatholog monitor therapeut intervent biomark vital diagnost brain diseas therapeut monitor biomark object measur evalu proxi indic pathophysiolog process respons therapeut intervent complex hurdl understand molecular pathophysiolog neurolog disord abil diagnos initi stage novel biomark neurolog diseas may surpass issu especi earli identif diseas risk valid biomark measur sever progress acut neuron injuri chronic neurolog diseas epilepsi migrain alzheim diseas parkinson diseas huntington diseas traumat brain injuri amyotroph later sclerosi multipl sclerosi brain diseas biomark deploy studi progress respons treatment includ noninvas imag tool acut chronic brain condit neuron biomark classifi four core subtyp blood base immunohistochem base neuroimag base electrophysiolog biomark neuron condit progress stage acut injuri inflamm neurodegener neurogenesi serv indic patholog status biomark critic target identif specif molecul cell tissu protein dramat alter throughout progress brain condit tremend progress biomark acut condit chronic diseas affect central nervous system | D000544;D009422 | T047;T048 |
36,233,033 | lyophil curcumin albumin nanoplex sucros cryoprotect aqueous reconstitut dissolut kinet solubl physicochem stabil amorph curcumin cur bovin serum albumin bsa nanoparticl complex nanoplex previous develop promis anticanc nanotherapi cur bsa nanoplex character aqueous suspens form present work develop dri powder form cur bsa nanoplex lyophil use sucros cryoprotect cryoprotect activ sucros examin sucros mass fraction evalu lyophil nanoplex aqueous reconstitut cur dissolut kinet solubl physicochem stabil effect sucros upon nanoplex day exposur c relat humid examin aqueous reconstitut ii cur dissolut iii cur bsa payload iv amorph form stabil v bsa structur integr good cryoprotect activ sucros evidenc preserv bsa integr good aqueous reconstitut result fast cur dissolut rate high kinet solubl thermodynam solubl similar nanoplex suspens aqueous reconstitut cur dissolut amorph form minim affect elev heat humid exposur treat nanoplex exhibit lower bsa payload loss increas protein aggreg postexposur advers effect bsa payload aggreg minim higher sucros mass fraction | D003474;D053758 | T121;T109;T073;T130 |
36,233,032 | kitlg promot glomerular endotheli cell injuri diabet nephropathi autocrin effect diabet nephropathi dn increas threat human health impact hyperglycemia metabolit advanc glycat end product age glomerular endotheli cell gec pathophysiolog mechan well explor result reveal age increas express secret kit ligand kitlg gec age kitlg promot endotheli mesenchym transit endomt gec increas permeabl gec aktextracellular signal regul kinas pathway inhibit kitlg effect imatinib prevent age medic endomt gec support belief kitlg critic factor gec injuri found higher kitlg level gec urin dbdb mice compar dbm mice urinari kitlg level posit correl urinari albumin creatinin ratio acr furthermor type diabet patient higher urinari kitlg level normal individu well urinari kitlg level posit correl urinari acr negat correl estim glomerular filtrat rate kitlg play pathogen role gec injuri dn might act biomark dn progress | D003920;D003928;D019089 | T047;T123;T116 |
36,233,031 | protect effect cxcr antagonist dbpr ischemia reperfus injuri rat porcin model myocardi infarct potenti adjunct therapi percutan coronari intervent cxcr antagonist claim reduc mortal myocardi infarct myocardi infarct mi anim presum due suppress inflammatori respons caus myocardi ischemia reperfus injuri thus subsequ facilit tissu repair cardiac function recoveri studi aim determin whether newli design cxcr antagonist dbpr could exert better vascular protect effect clinic counterpart eg amd allevi cardiac damag exacerb reperfus consequ find instead tradit continu treatment multipl dose treatment differ interv time singl dose treatment dbpr reperfus mi anim could attenu inflamm via protect oxid stress damag preserv vascularcapillari densiti integr via mobil endotheli progenitor cell lead desir fibrosi reduct recoveri cardiac function evalu lvef left ventricular eject fraction infarct heart rat mini pig respect thus high suggest cxcr antagonist given singl high dose prior reperfus provid maxim cardiac function improv base favor efficaci safeti profil indic test anim dbpr great potenti serv adjunct medicin percutan coronari intervent pci therapi acut mi patient | D009203;D015428;D062645;D019718 | T047;T046;T116;T192;T061;T129 |
36,233,030 | pathogen role heparan sulfat use biomark mucopolysaccharidos heparan sulfat hs essenti glycosaminoglycan gag compon proteoglycan present cell surfac extracellular matrix hs contain proteoglycan function structur constitu basal lamina also play versatil role various physiolog process includ cell signal organ develop thus inherit mutat gene associ biosynthesi degrad hs caus various diseas particular involv bone central nervous system cns mucopolysaccharidos mpss group lysosom storag disord involv gag accumul throughout bodi caus defici gag degrad enzym gag store differ differ type mpss particular hs deposit observ patient mps type ii iii vii involv progress neuropathi multipl cns system symptom therapi avail certain symptom type mpss signific unmet medic need remain neurocognit impair review present recent knowledg pathophysiolog role hs focus pathogenesi mpss also discuss possibl use signific hs biomark diseas sever therapeut respons mpss | D009083;D008059 | T047 |
36,233,029 | earli life stress affect bdnf regul role exercis intervent earli life stress el encompass exposur avers experi earli develop neglect maltreat anim human studi indic el maladapt effect brain develop leav individu vulner develop behavior neuropsychiatr disord later life result occur part disrupt brain deriv neurotroph factor bdnf gene regul play vital role earli neural program brain health adulthood potenti treatment mechan revers effect el bdnf express aerob exercis due neuroprotect properti posit impact bdnf express aerob exercis open door excit novel potenti treatment strategi behavior intervent readili freeli avail public review discuss current literatur investig use exercis intervent anim model el revers mitig el induc chang bdnf express also encourag futur studi investig sensit period exercis exposur well suffici durat exposur epigenet behavior outcom help lead standard practic exercis intervent field | D000076783;D019208 | T123;T116;T033 |
36,233,028 | integr multi omic analysi reveal differenti effect fructo oligosaccharid fos supplement human gut ecosystem chang gut ecosystem includ microbiom metabolom host immun system fructo oligosaccharid fos supplement evalu supplement fos show larg inter individu variabl absolut number fecal bacteria increas bifidobacterium fecal metabolom analysi reveal individu variabl fructos util respons fos supplement addit immunoglobulin iga tend increas upon fos intak peripher blood monocyt signific decreas upon fos intak kept decreas post fos phase analysi use metagenom approach show differ could least part due differ gene express enzym involv fructos metabol pathway studi show individu differ expect health benefit fos supplement accumul person knowledg gut ecosystem genet express may enabl effect instruct prebiot consumpt optim health benefit individu futur | D064307;D009844 | T001;T109;T032;T028 |
36,233,027 | enhanc hydrogen evolut reactiv phase tungsten dichalcogenid ws wse wte materi dft studi hydrogen evolut reaction play crucial role hydrogen gas product layer transit metal dichalcogenid tmds possess adjust electron structur tmds h phase structur propos substitut catalyst nonetheless systemat theoret analys catalyt properti tmds phase structur use dft calcul investig electrocatalyt properti w base dichalcogenid ws wse wte defect engin found interact h atom basal plane tune use non metal atom dope especi p therebi enhanc catalyt activ furthermor comput result demonstr high p dope concentr enhanc number activ site exhibit suitabl g h | D006859;D028561 | T196 |
36,233,026 | mechan action puls radiofrequ orthobiolog synergist effect radiofrequ energi common treatment modal chronic pain differ form radiofrequ base therapeut common concept generat electromagnet field appli area result neuromodul puls radiofrequ prf ablat specif focus relat prf due possibl modul accord mechan action orthobiolog propos mechan action prf pertain pain relief reli decreas pro inflammatori cytokin increas cytosol calcium concentr general effect immun system reduct format free radic molecul primari known properti orthobiolog constitut releas growth factor stimulus endogen repair analgesia improv function injur area review describ mechan action treatment pertin scientif refer use combin prf orthobiolog hypothesi synerg effect combin techniqu could benefit patient improv life qualiti | D059350;D061208 | T061;T047;T184 |
36,233,025 | multidisciplinari approach examin suscept microbi attack polyacryl polyurethan resin use art restor synthet polym use protect artwork deterior process colon fungi bacteria respons biodeterior process studi suscept synthet polyacryl polyurethan resin microorgan aspergillus niger atcc aureobasidium pullulan atcc chaetomium globosum atcc cladosporium cladosporioid atcc alternaria alternata bc penicillium citrinum ls pseudomona aeruginosa atcc investig microbi attack simul alon biocid relat growth observ day bacteria day fungi polyacryl polyurethan resin subject microbi attack regardless biocid treatment fungal growth complet coverag plate surfac penicillium citrinum show greatest adapt abil found examin resin p aeruginosa visibl differ resin regardless presenc biocid environment scan electron microscop esem reveal presenc fungal conidia hypha inocul resin fourier transform ir spectroscopi ftir atr indic chemic transform ir spectra particular hydrolysi ester differ polyacryl polyurethan resin probabl due differ chemic featur overal data stress chemic physic biolog deterior caus microorgan capabl degrad synthet polym still problem art restor new strategi must consid counteract phenomenon | D004202;D011140 | T167;T131;T109;T122 |
36,233,024 | collagen type xi inhibit lung cancer associ fibroblast function restrain integrin bind site avail collagen type matrix tumor microenviron includ cancer associ fibroblast caf play activ role non small cell lung cancer nsclc develop progress previous report collagen type xi integrin collagen receptor upregul nsclc latter promot tumor growth metastasi explor role collagen type xi nsclc stroma show presenc collagen type xi collagen type matric inhibit caf mediat collagen remodel cell migrat result inhibit caf depend lung tumor cell invas among collagen receptor express caf determin ddr integrin integrin mediat high affin bind collagen type xi demonstr collagen type xi restrain integrin bind site avail collagen type matric thus limit cell interact collagen type consequ caf fail activ fak p akt one hour interact collagen type ixi conclud collagen type xi may competit negat feedback role bind collagen type receptor | D000072645;D002289;D008175 | T191;T025 |
36,233,023 | analysi epstein barr virus ebv pd l express nasopharyng carcinoma patient non endem region purpos studi evalu status epstein barr virus ebv infect express program cell death ligand pd l tumor sampl patient nasopharyng carcinoma npc | D020031;D009303 | T191;T047 |
36,233,022 | plaga phospholipas promot fatti acid synthesi energi metabol pancreat cancer cell k ras mutat oncogen k ras often activ pancreat ductal adenocarcinoma pdac due frequent mutat gt drive multipl cellular process includ alter lipid metabol associ malign phenotyp howev role mechan alter lipid metabol k ras driven cancer remain poor understood studi use human pancreat epitheli cell harbor induc k ras gd hpne k ras gd pancreat cancer cell line found express phospholipas group iia plaga upregul oncogen k ras elev express plaga also observ pancreat cancer tissu correl poor surviv pdac patient abrog plaga sirna pharmacolog inhibit use tanshinon signific increas lipid peroxid reduc fatti acid synthas fasn express impair mitochondri function manifest decreas mitochondri transmembran potenti reduct atp product lead inhibit cancer cell prolifer studi suggest high express plaga induc oncogen k ras promot cancer cell surviv like reduc lipid peroxid abil facilit remov polyunsatur fatti acid lipid membran enhanc de novo fatti acid synthesi energi metabol support cancer cell prolifer plaga might function downstream mediat k ras could potenti therapeut target | D021441;D054501;D010190 | T191;T126;T116 |
36,233,021 | acidovorax citrulli effector aopv suppress plant immun interact aromat dehydratas adt watermelon bacteri fruit blotch bfb diseas cucurbit plant caus acidovorax citrulli although citrulli great destruct potenti molecular mechan pathogen citrulli clear particular regard type iii secret effector studi character type iii secret effector protein aopv citrulli strain aac show aopv signific inhibit reactiv oxygen speci express pti marker gene help growth pseudomona syringa de nicotiana benthamiana addit found aromat dehydratas adt watermelon target aopv aopv interact adt vivo vitro subcellular local indic adt aopv co locat cell membran togeth result reveal aopv suppress plant immun target adt cell membran find provid new character molecular interact citrulli effector protein aopv host cell | D029773;D042621 | T007;T168;T002 |
36,233,020 | recombin human igg antibodi protect oxldl induc oxid stress apoptosi human monocytemacrophag thp cell upregul msra via sirt foxo axi oxid low densiti lipoprotein oxldl induc oxid stress apoptosi consid critic contributor cardiovascular diseas methionin sulfoxid reductas msra potent intracellular oxidoreductas serv essenti factor protect cell oxid damag first provid evid recombin human igg antibodi treatment upregul express msra thp cell defend oxldl induc oxid stress apoptosi also observ upregul msra regul forkhead box transcript factor foxo acetyl foxo increas expos oxldl declin treat recombin human igg antibodi addit identifi silent inform regul sirt suppress foxo acetyl import sirt foxo defici impair anti oxid stress anti apoptot effect recombin human igg antibodi togeth result suggest recombin human igg antibodi exert anti oxid stress anti apoptot function upregul msra via sirt foxo axi | D051150;D056564 | T126;T123;T116 |
36,233,019 | iron oxid powder respons generat industri polypropylen wast co catalyst pyrolysi non addit resin synthesi polymer resin great import review raw materi equip use avoid presenc compound may affect effect polymer characterist plastic obtain iron oxid compound present reactor mainten due techniqu use clean equip affect characterist resin reduc qualiti studi presenc feo differ concentr evalu determin effect properti pyrolysi polypropylen resin use x ray refract determin element sampl evalu thermal degrad tga variat molecular weight measur mfi compound obtain pyrolysi chromatographi result show thermal degrad decreas feo concentr increas mfi relationship direct proport evalu compound obtain pyrolysi show increas product alcohol alkyn keton acid decreas alkan alken show feo affect properti polypropylen compound produc pyrolysi | D011126;D000077319 | T109;T122;T070 |
36,233,018 | effect tauroursodeoxychol acid inflamm ocular alkali burn inflamm main caus corneal retin damag ocular alkali burn oab aim studi investig effect tauroursodeoxychol acid tudca ocular inflamm mous model oab oab induc cblj mous cornea use naoh tudca mgkg pbs inject intraperiton ip day day prior establish oab model singl inject infliximab mgkg administ ip immedi oab tudca suppress infiltr cd posit cell decreas mrna protein level upregul tnf il cornea retina oab furthermor tudca treatment inhibit retin glial activ oab tudca treatment amelior cnv promot corneal epithel also attenu rgc apoptosi preserv retin structur oab final tudca reduc express endoplasm reticulum er stress molecul ire grp chop retin tissu oab mice present studi demonstr tudca inhibit ocular inflamm protect cornea retina injuri oab mous model result provid potenti therapeut intervent treatment oab | D002057 | T037 |
36,233,017 | gene structur biochem character four chlorophyllas solanum lycopersicum recent studi confirm chlorophyllas clh long found chlorophyl chl dephytyl enzym initi chl catabol function leaf senesc relat chl breakdown yet clh consid involv fruit degreen respond extern hormon stimuli purpos work elucid detail biochem structur properti gene express four clhs solanum lycopersicum genom understand role solanum lycopersicum chlorophyllas slclhs slclh predomin express clh gene leaf fruit developmentripen stage slclh matur green fruit modul light slclh contain high conserv ghsxg lipas motif ser asp catalyt triad identifi ser asp essenti catalyt triad site direct mutagenesi recombin slclh kinet analysi recombin enzym reveal slclh high hydrolysi activ chl chl b pheophytin phein prefer chl chl b phein slclh show low activ chl chl b slclh show chl dephytyl activ recombin slclh differ ph stabil temperatur optimum remov predict n termin process peptid caus partial loss activ recombin slclh compromis slclh activ differ characterist among slclhs impli may differ physiolog function tomato | D018551 | T168;T002 |
36,233,016 | comprehens studi gradient condit deep proteom discoveri complex protein matrix bottom mass spectrometri base proteom well develop technolog base complex peptid mixtur proteolyt cleavag protein wide appli protein identif character quantit tim tof mass spectromet excel platform bottom proteom studi due rapid acquisit high sensit remain challeng bottom proteom approach achiev proteom coverag liquid chromatographi lc common use prior mass spectrometri ms analysi fraction peptid mixtur lc gradient affect peptid fraction proteom coverag investig effect gradient type time durat find optim gradient condit five gradient type linear logarithm like expon like stepwis step linear three differ gradient length min min min two sampl load amount ng ng two load condit use trap column trap column studi effect chromatographi variabl protein group peptid spectral count use hela cell digest explor result indic step linear gradient perform best among five gradient type studi optim gradient durat depend protein sampl load amount use trap column help enhanc protein identif especi low abund protein msfragger peak studio high similar protein group identif msfragger identifi protein group among differ gradient condit compar peak studio combin result databas search engin expand identifi protein group | D020543;D053719 | T063;T123;T116 |
36,233,015 | studi biogen spindl shape iron oxid nanoparticl pseudostaurosira trainorii field laser desorptionion applic nanostructur assist laser desorptionion mass spectrometri naldi ms gain attent analysi wide rang molecul present investig pseudostaurosira trainorii mediat biosynthes iron oxid nanoparticl ionp util nanostructur assist ionize desorpt laser desorptionion mass spectrometri ldi ms chain form diatom p trainorii show effici product ionp fe ph aqueous solut intracellular extracellular level whole biomass extern media turn dark orang color day reaction fe solut scan electron microscop sem imag illustr surfac fe expos frustul p trainorii entir cover synthes nanostructur contrast natur surfac ornament control cell ionp load frustul also exhibit catalyt properti decolor yellow color nitrophenol h reaction transmiss electron microscop tem imag confirm produc particl spindl shape nm length nm width biogen ionp util inorgan matrix ldi ms show high sensit toward small molecul glucos alanin triacylglycerol nano picomolar level per spot respect present biocompat techniqu offer new perspect nanobiotechnolog product spindl shape ionp appli futur prepar naldi plate | D017377;D053758 | T073;T204 |
36,233,014 | investig potenti cardiovascular toxic two anti leukemia drug asciminib ponatinib zebrafish embryo bcr abl fusion protein kinas druggabl target exclus express patient chronic myeloid leukemia cml sever anti leukemia medicin target protein develop recent year howev therapeut option limit cml patient bear multipl bcr abl mutat ponatinib pon potent tyrosinas inhibitor one approv drug manag bcr abl ti mutant diseas howev treatment patient pon report sever side effect relat cardiovascular event asciminib asc first alloster inhibitor approv target myristoyl pocket bcr abl protein inhibit protein activ differ mechan inhibit open possibl co exposur medicin report cardiovascular side effect due combin use pon asc pre clinic clinic studi minim thus studi aim observ potenti cardiovascular relat side effect co exposur asc pon use zebrafish anim model studi zebrafish acut expos compound cardiovascular physiolog paramet gene express relat cardiovascular develop evalu demonstr combin asc pon observ effect concentr noec caus signific chang cardiac perform paramet zebrafish howev signific increas nkx express level substanti decreas blood flow veloc record suggest combin compound noec caus mild cardiovascular relat side effect | D000970;D015464;D011724 | T121;T109;T191 |
36,233,013 | genet ablat nrf exacerb neuroinflamm ocular autoimmun experiment autoimmun uveoretin eau anim model non infecti uveiti develop immun retin antigen interphotoreceptor retinoid bind protein irbp nuclear factor erythroid nf e relat factor nrf respons regul antioxid inflammatori respons studi investig role nrf develop eau clinic patholog examin demonstr retin inflamm exacerb nrf knockout nrf ko mice compar wild type wt mice express inflammatori cytokin ifn il il retina signific elev nrf ko mice gfap posit cell astrocyt iba posit cell microglia cell retina numer nrf ko mice compar wt mice furthermor examin suppress effect nrf activ cddo im cyano dioxooleana dien oyl imidazolin develop eau treatment cddo im signific reduc clinic patholog score eau compar vehicl treat mice find suggest nrf play regulatori role pathogenesi autoimmun uveoretin activ nrf system may therapeut potenti protect vision autoimmun neuroinflamm | D001327;D048288;D014605 | T047;T109 |
36,233,012 | polyphenol potent epigenet agent cancer human diseas cancer caus aberr epigenet regul polyphenol play major role mammalian epigenom regul mechan protein remodel chromatin fruit seed veget well food supplement polyphenol found compound one power anticanc agent antioxid gallic acid kaempferol curcumin quercetin resveratrol among other potent anti tumor effect help revers epigenet chang associ oncogen activ tumor suppressor gene inactiv role dietari polyphenol play restor epigenet alter cancer cell particular focus dna methyl histon modif summar also discuss natur compound modul gene express epigenet level describ molecular target cancer highlight potenti polyphenol altern therapeut approach cancer sinc modul epigenet activ | D000970;D003474;D035683;D009369 | T121;T191;T109;T123;T130;T114 |
36,233,011 | research progress therapeut effect polysaccharid non alcohol fatti liver diseas regul gut liver axi non alcohol fatti liver diseas nafld common chronic liver diseas affect global public health present induc cirrhosi liver cancer serious case howev nafld multifactori diseas still lack research mechan therapeut strategi develop gut liver axi theori associ gut liver axi pathogenesi nafld gradual disclos polysaccharid kind natur product advantag low toxic multi target multi pathway action report polysaccharid affect gut liver axi multipl interrel level maintain ecolog balanc gut microbiota gm regul metabolit gm improv intestin barrier function therebi play protect role nafld studi great scientif signific understand nafld base gut liver axi develop safe effect medic treatment herein review recent progress polysaccharid improv nonalcohol fatti liver diseas nafld gut liver axi | D001688;D000069196;D065626 | T047;T007;T121;T001;T123 |
36,233,010 | tempor compar rna transcriptom profil annexin gene famili salivari versus lacrim gland sjgren syndrom suscept cblnod aecaec mous general accept hypothesi initi activ immun autoimmun respons argu alarmin releas injur die andor activ immun cell product complex receptor activ signal transduct pathway recruit immun cell site injuri recruit cell stimul initi immun andor cellular repair respons multipl divers famili alarmin interleukin il heat shock protein hsp toll like receptor tlr plus individu molecular entiti galectin calreticulin thymosin alpha defensin rage interferon one phylogenet conserv famili annexin protein known promot extens rang biomolecular cellular product direct indirect regul inflamm immun activ present report examin tempor express profil mammalian annexin gene anxa anxa appli tempor genom wide transcriptom analys ex vivo salivari lacrim gland cblnod aecaec mous model sjgren syndrom ss human autoimmun diseas character primarili sever dri mouth dri eye symptom result indic annexin gene anax exhibit upregul express initi time upregul occur earli week age prior covert sign ss like diseas profil two gland similar ident suggest possibl ss like diseas may uniform two gland nevertheless earli pre clinic concomit upregul express specif set alarmin within immun target organ repres potenti target identifi pre clinic stage human ss well fact would clear impact futur intervent therapeut strategi | D017302;D007765;D012859;D013947 | T023;T047;T030;T116;T123;T125 |
36,233,009 | peg induc pyroptosi regul express hmgb promot hema migrat endometriosi endometriosi em common gynecolog diseas prostaglandin e pge induc chronic pelvic inflamm cell pyroptosi form program cell death base inflammasom activ involv em extent involv role remain unclear present studi aim evalu pge induc pyroptosi em influenc pge em progress use western blot found express pge pyroptosi relat protein nlrp cleav caspas interleukin il il higher em tissu normal endometri tissu level pge il il serum patient em cell cultur fluid also detect use transwel assay verifi pge promot hema migrat via nlrpcaspas pyroptot pathway pge induc pyroptosi upregul express high mobil group box hmgb e cadherin vimentin immunohistochemistri analysi confirm pge induc pyroptosi contribut em invas result suggest pge induc pyroptosi affect progress em chang migrat abil pyroptot cell upregul express hmgb e cadherin vimentin find provid crucial evid new treatment pathway use anti inflammatori drug em | D004715;D024243 | T191;T047;T123;T116 |
36,233,008 | role cyclomodulin microbi metabolit bacteri microecolog macroorgan carcinogenesi number bacteria colon human bodi produc toxin effector caus chang eukaryot cell cycl cyclomodulin low molecular weight compound butyr lactic acid secondari bile acid cyclomodulin metabolit necessari bacteria adapt factor influenc direct select ecolog nich host process establish two way communic macroorgan compound caus limit damag host despit abil disrupt key process eukaryot cell lead patholog chang possibl negat consequ cyclomodulin metabolit action includ potenti role carcinogenesi particular abil caus dna damag increas genom instabl interfer cancer associ regulatori pathway review aim examin cyclomodulin bacteri metabolit import factor bacteri surviv interact host organ show heterogen effect oncogenesi depend surround microenviron patholog condit host genet background | D001427 | T131;T123;T116 |
36,233,007 | differenti effect dopamin receptor activ low frequenc oscil prefront cortex hippocampus may bias bidirect prefront hippocamp coupl dopamin receptor dr mechan implic psychiatr diseas character cognit deficit includ schizophrenia adhd autism cellular mechan poor understood impair neuron synchron cortic network propos contribut deficit anim experi dr activ shown generat aberr increas gamma oscil reduc perform cognit task requir function prefront cortex pfc hippocampus hpc network fast oscil gamma rang import local synchron within neuron ensembl long rang synchron distant structur achiev slow rhythm delta theta alpha rang characterist slow oscil vari structur cognit task hpc activ domin theta rhythm wherea pfc generat uniqu oscil hz rang order investig role dr slow rhythm cortic activ record rat urethan anesthesia slow oscil elicit control manner without behavior confound electr stimul brainstem reticular format local field potenti segment stimul extract subject fast fourier transform obtain power densiti spectra select dr agonist mgkg antagonist l mgkg inject system peak power two frequenc rang compar inject found dr compound signific chang activ hpc pfc direct effect opposit two structur dr agonist enhanc pfc slow rhythm delta hz suppress hpc theta wherea antagonist opposit effect analog chang two slow rhythm also found thalam nucleus reunien connect forebrain structur slow oscil play key role interregion cortic coupl delta theta oscil shown particular entrain neuron fire modul gamma activ interconnect forebrain structur relat hpc theta domin pfc thus result studi indic dr activ may introduc abnorm bias bidirect pfc hpc coupl revers dr antagonist | D017397;D050638 | T023;T116;T030;T192;T029 |
36,233,006 | resvega nutraceut prepar affect nfb pathway prolong anti vegf effect bevacizumab undifferenti arp retina cell age relat macular degener amd irrevers chronic degen patholog affect retina despit therapeut advanc thank use anti vascular endotheli growth factor vegf agent resist mechan found accentu visual deficit present studi explor whether nutraceut formul compos omega fatti acid resveratrol call resvega abl disrupt vegf secret human arp retina cell found resvega inhibit vegf secret decreas pik akt mtor nfb signal pathway nfb signal pathway resvega inhibit phosphoryl inhibitor nfb ib bind nfb dimer sequest cytoplasm thus nfb subunit migrat nucleus normal bind stimul transcript target gene vegf ib kinas complex ikk also affect resvega sinc nutraceut formul decreas ikk ikk subunit ikk subunit requir stimul ikk interest highlight resvega could prolong anti angiogen effect avastin anti vegf agent typic use clinic practic result suggest resvega may potenti interest nutrit supplement amd | D015525;D008268 | T121;T047;T109;T123 |
36,233,005 | staphylococcus aureus kerat taiwan genotyp antibiot suscept clinic featur staphylococcus aureus import pathogen kerat vision threaten diseas aim investig genotyp antibiot suscept clinic featur aureus kerat explor possibl role panton valentin leucocidin pvl major virul factor aureus recruit patient cultur proven aureus kerat chang gung memori hospit taiwan pvl gene multilocus sequenc type mlst staphylococc cassett chromosom mec scc mec puls field gel electrophoresi pfge perform antibiot suscept verifi use disk diffusion test patient aureus kerat caus methicillin resist aureus mrsa isol pvl gene predomin genotyp mrsa isol ccpfge type dscc mec v pvl methicillin sensit aureus mssa approxim mrsa suscept fluoroquinolon signific differ clinic featur treatment visual outcom observ mrsamssa pvl pvl group taiwan approxim one third aureus kerat caus mrsa main communiti associ mrsa although mrsa isol resist mssa clinic characterist similar two group fluoroquinolon could good empir antibiot aureus kerat | D017714;D007634;D055624;D013203 | T007;T047 |
36,233,004 | anti inflammatori effect carrageenanechinochrom complex experiment endotoxemia anti inflammatori effect crgech complex lps induc endotoxemia investig vivo mice vitro lps stimul raw cell periton macrophag result indic crgech complex suppress lps induc inflammatori respons reduc product ros macrophag furthermor vivo experi indic crgech complex minim disord physiolog metabol process mice subject lps intox reduc level proinflammatori cytokin mous serum prevent administr crgech complex mice prevent endotoxin induc damag mous model endotoxemia increas mice resist lps prevent increas level proinflammatori cytokin tnf work show molecular dock ech interact carrageenan h donor h acceptor bond involv format complex | D019446 | T047 |
36,233,003 | anthocyanin biosynthesi induc myb transcript factor plant anthocyanin act polyphenol pigment ubiquit found plant anthocyanin play role health promot antioxid also protect kind abiot biotic stress recent studi found myb transcript factor myb tfs could posit negat regul anthocyanin biosynthesi understand role myb tfs essenti elucid myb tfs regul accumul anthocyanin review summar signal pathway medic myb tfs anthocyanin biosynthesi includ jasmon acid ja signal pathway cytokinin cks signal pathway temperatur induc light signal proteasom pathway nac tfs bhlh tfs moreov structur regul gene induc myb tfs target gene bound activ suppress myb tfs crosstalk myb tfs protein found vital import regul anthocyanin biosynthesi studi focus recent knowledg concern regul signal mechan myb tfs anthocyanin biosynthesi cover signal pathway gene express target gene protein express | D000872;D014157 | T121;T109;T123;T116 |
36,233,002 | respons ileal fecal microbiota withdraw pancreat enzym replac therapi porcin model exocrin pancreat insuffici littl known regard interplay microbiota pancrea function human investig usual limit distal site name analys fecal sampl aim studi investig ileal fecal microbiota respons pancreat enzym replac therapi pert porcin model exocrin pancreat insuffici epi pert stop ten day ileo cecal fistul minipig experiment induc epi n ileal digesta well fecal sampl obtain withdraw withdraw reintroduct pert profound communiti chang occur three day enzym omiss maintain throughout withdraw phase reduct divers togeth relat abund chang sever taxa particular increas bifidobacteria site lactobacilli fece observ overal dysbiosi event ileum accumul effect distal part gastrointestin tract addit alter occur colon chang revers continu pert one week later bacteri communiti resembl baselin studi demonstr rapid profound impact enzym withdraw bacteri communiti contribut understand interplay pancrea function microbiota | D010188;D064307 | T001;T047;T032;T028 |
36,233,001 | develop hybrid biomimet enamel biocomposit interfac studi molecular featur use synchrotron submicron atr ftir microspectroscopi multivari analysi techniqu use biomimet strategi bioinspir materi work propos new technolog approach creat hybrid transit layer enamel dental biocomposit purpos amino acid booster condition base set polar amino acid lysin arginin hyaluron acid calcium alkali modifi adhes base bisgma nanocrystallin carbon substitut hydroxyapatit use dental enamel restor molecular properti hybrid interfac form use propos strategi understood use method multivari statist analysi spectral inform collect use techniqu synchrotron infrar microspectroscopi result obtain indic possibl form bond mimic properti natur tissu control molecular properti hybrid layer diffus amino acid booster condition compon calcium alkali modifi adhes nanocrystallin carbon substitut hydroxyapatit hybrid interfac region creat structur stabil reconstitut crystallin enamel layer develop technolog form basi individu person approach dental enamel restor | D001840;D003804 | T061;T031 |
36,233,000 | super resolut imag reveal dynam reticular cytoophidia ctp synthas ctps form filament structur term cytoophidia cell three domain life order studi mesoscal structur cytoophidia perform fluoresc recoveri photobleach frap stimul emiss deplet sted microscopi human cell use egfp dimer tag tool explor physic properti cytoophidia find cytoophidia dynam reticular reticular structur ctps cytoophidia may provid space compon impdh addit observ ctps granul tentacl | D019731;D003570 | T126;T116;T123;T114 |
36,232,999 | investig antibacteri mechan biogen tellurium nanoparticl precursor tellurit antibacteri tellurium nanoparticl advantag high activ biocompat microbi synthesi te nanoparticl green technolog build new ecolog relationship divers environ howev antibacteri mechan te nanoparticl larg unclear studi report bacteri synthesi rod shape te nanoparticl biot high antibacteri activ escherichia coli morpholog permeabl examin indic membran damag primari reason antibacteri activ biot rather ros product dna damag moreov comparison transcriptom relat phenotyp reveal differ antibacteri mechan biot tellurit base evid propos antibacteri mode rod shape biot posit charg biot interact cell membran electrostat attract penetr membran use sharp end contrast tellurit toxic might involv sulfur metabol | D053758;D013691 | T131;T196;T073 |
36,232,998 | hepatocyt specif smad defici allevi liver fibrosi via pp pathway liver fibrosi wound heal respons caus abnorm accumul extracellular matrix produc activ hepat stellat cell hscs studi focus activ hscs liver fibrosi whether hepatocyt modul process fibrosi still unclear sma mother decapentapleg homologu smad key intracellular transcript mediat transform growth factor tgf develop progress liver fibrosi howev role hepatocyt smad develop fibrosi poor elucid explor function role hepatocyt smad molecular mechan liver fibrosi ccl induc liver fibrosi model establish mice hepatocyt specif smad delet smad hep found hepatocyt specif smad defici reduc liver inflamm fibrosi allevi epitheli mesenchym transit inhibit hepatocyt prolifer migrat molecular smad delet hepatocyt suppress express inhibitor differenti id secret connect tissu growth factor ctgf hepatocyt subsequ activ p p signal pathway hscs epiderm growth factor receptor depend manner taken togeth result clear demonstr smad express hepatocyt play import role promot liver fibrosi could therefor promis target futur anti fibrot therapi | D022781;D008103;D051901 | T025;T123;T116;T047 |
36,232,997 | new oxazolo pyrimidin potenti anticanc agent design synthesi vitro biolog activ research cancer larg group diseas rapid prolifer abnorm cell general lead metastasi surround tissu distant one lymphat blood vessel make second lead caus death worldwid main challeng design modern anticanc therapi develop select compound exploit specif molecular target work novel oxazolo pyrimidin deriv design synthes evalu vitro cytotox activ panel four human cancer cell line lung carcinoma breast adenocarcinoma mcf metastat colon adenocarcinoma lovo primari colon adenocarcinoma ht along p glycoprotein inhibitori abil pro apoptot activ oxazolo pyrimidin deriv structur similar nucleic purin base general character presenc pharmacolog favor isoxazol substitu posit aliphat amino chain posit condens heterocycl system silico analysi obtain compound identifi potent inhibitori activ toward human vascular endotheli growth factor receptor vegfr molecular dock perform assess bind mode new deriv vegfr activ site physicochem pharmacokinet pharmacolog properti ie adm administr distribut metabol excret also predict assess druglik particular compound g n n dimethylamino propyl substitu found potent ht cell line cytotox concentr cc exceed activ fluorouracil cc equal activ cisplatin cc less toxic healthi human cell normal human dermal fibroblast nhdfs refer drug result suggest compound g potenti promis candid treatment primari colorect cancer | D000230;D000970;D003110 | T191;T109;T121 |
36,232,996 | aldha odf qsox microrna p express forecast recurr tmprss erg posit prostat cancer follow radic surgeri patient may suffer relaps import identifi patient therapi tactic modifi appropri exist stratif scheme display probabl recurr enough precis sinc local advanc prostat cancer pca classifi high risk rank greater detail pca case belong tmprss erg subtyp suffici homogen group high precis prognost marker search possibl studi includ two independ cohort base high throughput sequenc qpcr data result abl suggest perspect train model involv deep neural network base qpcr data mrna mirna clinicopatholog criteria use recurr risk forecast patient tmprss erg posit local advanc pca model use aldha odf qsox hsa mir p isup pt auc addit prognost model use identifi differenti express gene mirna mirna target pair found correl prognosi present interactom network | D035683;D011471 | T191;T123;T114 |
36,232,995 | impact acet versus citrat dialys intermediari metabol target metabolom approach acet wide use dialys buffer avoid precipit bicarbon salt howev even low concentr would nt surpass metabol capac kreb tricarboxyl acid tca cycl metabol rout activ lead undesir clinic consequ poor understood mechan studi aim add inform could biolog explain clinic improv found patient use citrat dialys unicentr cross prospect target metabolom studi design analyz differ two dialys one contain mmoll acet ad mmoll citrat cd fifteen metabolit studi investig chang induc tca cycl glycolysi anaerob metabol keton bodi triglycerid aminoacid metabol twenti one patient complet studi citrat increas dialysi session cd use without surpass normal valu differ found next tca cycl step show increas substrat accumul use ad lactat decreas pyruv remain stabl ketogenesi boost dialysi acetylcarnitin myo inositol reduc dialysi glycerol remain constant last glutam glutar decreas due inhibit amino acid degrad studi rais new hypothes need investig understand better biochem process dialysi differ dialys buffer induc patient metabol | D019343;D015314 | T121;T109;T123 |
36,232,994 | new express system base psychrotoler debaryomyc macquariensi yeast applic product cold activ galactosidas paracoccus sp yeast provid attract hostvector system heterolog gene express current use yeast base express platform includ mesophil thermotoler speci eukaryot express system work low temperatur could particular use product thermolabil protein protein tend form insolubl aggreg purpos express system base antarct psychrotoler yeast debaryomyc amp nbsp macquariensi strain capabl grow temperatur rang c develop optim physic cultur condit macquariensi ferment follow temperatur c ph aerat rate vvm stir speed rpm four integr plasmid vector equip express cassett contain constitut gap promot cyc transcript termin macquariensi construct use clone express gene encod cold activ galactosidas paracoccus sp yield ul recombin yeast cultur recombin macquariensi strain mitot stabl select non select condit macquariensi hostvector system success util synthesi heterolog thermolabil protein altern microbi express system | D010230;D004718;D001616 | T116;T007;T121;T126;T004 |
36,232,993 | direct interact coronavirus nonstructur protein melanoma differenti associ gene modul type interferon respons coronavirus infect coronavirus nonstructur protein nsp multi function protein play critic role viral replic regul host antivir innat immun studi demonstr nsp sever acut respiratori syndrom coronavirus sar cov avian coronavirus infecti bronchiti virus ibv direct interact melanoma differenti associ gene mda render inhibitori effect mda mediat type interferon ifn respons co express mda wild type truncat nsp construct least three interact region map papain like proteas plpro domain two domain locat n c termin region identifi sar cov nsp furthermor introduc point mutat catalyt triad deubiquityl activ plpro domain sar cov ibv nsp shown respons suppress mda mediat type ifn respons also demonstr mda nsp abl interact ubiquitin ubiquitin protein contribut interact two protein studi confirm antagonist role nsp mda mediat type ifn signal highlight complex interact multi function viral protein innat immun respons | D018352;D001351;D007370;D000072640;D000086402;D017361 | T047;T116;T121;T126;T123;T129;T005 |
36,232,992 | dissect stem aggress intracrani meningioma prognost role sox express meningioma most benign tumor time behav aggress display recurr despit gross total resect gtr progress overt malign case repres clinic challeng particular difficult recogn first diagnosi sox sex determin region box transcript factor key role stem cell mainten associ tumorigenesi varieti cancer purpos present work dissect role sox predict aggress meningioma analyz progressiverecurr grade meningioma grade meningioma control non recur grade grade meningioma patient enrol sox express evalu use immunohistochemistri ihc rt pcr final analysi includ patient ihc abl reliabl assess sox express shown good correl mrna level spearman r p auc sox express intrins characterist singl tumor chang follow recurr progress import sox express first surgeri strong relat meningioma clinic behavior histolog grade risk recurr final surviv data suggest prognost role sox express whole seri overal recurr free surviv p lt p respect thus sox assess could great help clinician inform adjuv treatment follow | D008577;D008579;D055748 | T191;T123;T116 |
36,232,991 | plasma oxylipin signatur provid deep phenotyp metabol syndrom complementari clinic criteria metabol syndrom met complex condit encompass constel cardiometabol abnorm oxylipin superfamili lipid mediat regul mani cardiometabol function plasma oxylipin signatur could provid new clinic tool enhanc phenotyp met pathophysiolog high throughput valid mass spectrometri method allow quantit profil oxylipin appli identifi valid oxylipin signatur met two independ nest casecontrol studi involv particip identifi oxylipin signatur met coin oxyscor includ oxylipin high perform classif replic cross valid auc roc ci ci discoveri replic studi respect correl analysi comparison classif model incorpor met criteria show oxylipin signatur bring consist complementari inform clinic criteria link regul various biolog process candid oxylipin provid integr phenotyp met regard activ andor negat feedback regul crucial molecular pathway may help identifi patient higher risk cardiometabol diseas oxylipin signatur patient metabol syndrom enhanc met phenotyp may ultim help better stratifi risk cardiometabol diseas | D002318;D024821 | T047 |
36,232,990 | current research pathogenesi nafldnash gut liver axi gut microbiota dysbiosi leaki gut syndrom global lifestyl chang led increas incid non alcohol fatti liver diseas nafld non alcohol steatohepat nash requir depth research understand mechan develop new therapeut strategi particular high fat high fructos diet shown increas intestin permeabl expos liver endotoxin inde accumul evid point link liver diseas intestin axi includ dysbiosi gut microbiom leaki gut syndrom review mechan contribut link liver small intestin pathogenesi nafldnash focus role intestin microbiota metabolit influenc enzym essenti proper liver metabol function advanc next generat sequenc technolog facilit analys metagenom provid new insight role intestin microbiota function physiolog patholog mechan review summar recent research link gut microbiom liver diseas offer new research direct elucid detail mechan novel target treatment prevent | D000069196;D065626 | T007;T001;T047 |
36,232,989 | insight molecular target breast cancer brain metastasi brain metastasi one major reason death breast cancer bc patient signific affect qualiti life physic activ interdepend sever individu clear evid scientif literatur depict exact mechan relat brain metastasi bc patient tendenc develop breast cancer brain metastas bcbms differ bc subtyp vari almost half tripl negat breast cancer tnbc er pr one third human epiderm growth factor receptor posit around one tenth lumin subclass er estrogen posit pr progesteron posit breast cancer review focus molecular pathway possibl therapeut target bcbms potent drug differ stage clinic trial view increas number clinic trial system studi scientif communiti hope unravel under mechan bcbms help design effect treatment regimen multipl molecular target | D001932;D001943;D064726 | T191 |
36,232,988 | mechan underlin inflammatori pain sensit mice select high low stress induc analgesia role endocannabinoid microglia work strive determin whether endocannabinoid system activ could account differ acut inflammatori pain sensit mous line select high ha low la swim stress induc analgesia ssia mice receiv intraplantar inject formalin intens nocifens behaviour score assess contribut endocannabinoid system mice intraperiton ip inject rimonab mgkg prior formalin minocyclin mgkg ip administ investig microgli activ possibl involv endogen opioid system investig naloxon mgkg ip cannabinoid receptor type cnr cnr opioid receptor subtyp oprm oprd oprk mrna level quantifi qpcr structur central nocicept circuit level anandamid aea arachidonoylglycerol ag measur liquid chromatographi coupl mass spectrometri method lc msms interphas higher pain threshold ha mice correl increas spinal anandamid ag releas higher cnr transcript downregul oprd oprm mrna note ha la mice respect howev differ naloxon sensit observ either line oppos la mice inflammatori pain sensit ha mice tonic phase attribut enhanc microgli activ evidenc enhanc aif il mrna level conclud cnr inhibitori signal one mechan respons decreas pain sensit ha mice interphas increas microgli activ correspond decreas pain threshold tonic inflammatori phase | D000698;D063388 | T061;T109;T123 |
36,232,987 | tcga molecular prognost group endometri carcinoma current knowledg futur perspect four tcga base molecular prognost group endometri carcinoma ec ie pole mutant mismatch repair mmr defici p abnorm specif molecular profil nsmp recent integr esgo estro esp guidelin pole mutant mmr defici group associ high mutat load morpholog heterogen inflammatori infiltr group frequent high grade endometrioid undifferentiateddedifferenti mix histotyp pole mutant ec show good prognosi requir adjuv treatment although manag case stage gt ii still undefin mmr defici ec show intermedi prognosi current substratifi base clinicopatholog variabl might prognost valu group may benefit immunotherapi p mutant ec typic high grade often morpholog ambigu account virtual serous ec carcinosarcoma mix ec half clear cell ec show poor prognosi treat chemoradiotherapi subset may benefit inhibitor parp inhibitor nsmp group frequent tcga group prognosi high variabl affect clinicopathologicalmolecular factor still evalu conclus tcga classif improv diagnosi risk stratif manag ec studi need resolv point uncertainti still exist | D018269;D016889 | T191 |
36,232,986 | ai base protein interact screen identif aisid studi present aisid method extend alphafold multim success structur predict toward identifi specif protein interact optim aisidscor method test identifi bind protein human tnfsf tumor necrosi factor superfamili member human tnfrsf tnf receptor superfamili member tnfrsf member rank aisidscor among tnfsf member correct pair result highest aisidscor tnfrsf member known interact tnfsf member correct pair tnfsf tnfrsf member pair could found top five includ pair top three seat aisidscor rank surpris specif interact tnfsf tnf relat apoptosi induc ligand trail decoy receptor dcr dcr gave highest aisidscor list structur dcr dcr unknown data strong suggest alphafold multim might use comput screen tool find novel specif protein bind aisid method may broad applic protein biochemistri extend applic alphafold far beyond structur predict | D018124;D053221 | T123;T116;T192 |
36,232,985 | bhlh transcript factor control pollen wall develop via specif transcript metabol network arabidopsi thaliana pollen wall special extracellular cell wall protect male gametophyt various environment stress facilit pollin report bhlh bhlh togeth requir develop pollen wall regul specif downstream transcript metabol network exin intin structur bhlh bhlh pollen grain sever defect untarget metabolom transcriptom analys reveal accumul pollen wall morphogenesi relat metabolit includ polysaccharid glyceryl deriv flavonol signific chang express metabol enzym encod gene transport encod gene relat pollen wall morphogenesi downregul bhlh bhlh mutant among downstream target gene cslb novel target biolog function report yet found bhlh interact two e box sequenc promot cslb direct activ express cslb cslb mutant allel show bhlh bhlh like pollen development defect pollen grain exhibit defect pollen wall structur | D017360;D029681 | T116;T002 |
36,232,984 | variat mirna content cow raw milk depend dairi product system pastur base milk present sever advantag milk intens industri farm term human health environ anim welfar social aspect highlight need reliabl method differenti milk accord origin market explor whether mirna profil could serv marker milk product system compar level previous describ mirna milk four product system altogeth milk sampl graze zero graze grass silag corn silag total rna extract fat phase mirna level quantifi real time quantit pcr level mirna bta mir bta mir higher graze system corn silag farm level bta mir bta mir bta mir show differ differ farm manag mirna bta mir bta mir predict particip common function relat fat metabol fatti acid elong four differenti express mirna predict particip transport cell differenti metabol result suggest dairi product system influenc level mirna milk fat bta mir bta mir may potenti biomark identifi milk pastur manag system | D035683;D008892 | T123;T031;T168;T114 |
36,232,983 | sono enzymat embed antibacteri silver lignin nanoparticl cork filter materi water disinfect provid clean drink water great challeng worldwid especi low incom countri access safe water limit last decad new biotechnolog approach explor improv water manag among use antimicrobi nanoparticl design innov central decentr point use water treatment system microbi decontamin receiv consider attent herein antimicrobi lignin cap silver nanoparticl aglnp embed residu cork piec use high intens ultrasound coupl laccas mediat graft obtain biofunction nanomateri develop aglnp coat cork prove high effici drastic reduc number viabl gram negat escherichia coli gram posit staphylococcus aureus liquid medium addit coat cork character use ftir atr spectroscopi sem imag use filter bed point use devic water disinfect construct water filter system signific reduc amount viabl e coli resist bacillus cereus spore filter water oper increas resid time h therefor present result prove obtain cork base antimicrobi nanocomposit materi could use filter medium develop water filtrat system control pathogen dissemin | D000890;D060766;D053768;D018508 | T073;T052;T167;T121;T057 |
36,232,982 | impact high fat diet metabolom profil cbl mous strain differ inbr mous strain vari substanti behavior metabol phenotyp physiolog patholog condit purpos studi extend knowledg distinct cope strategi challeng event two differ adapt mous strain cblntac bl ssvevtac sv thus aim investig possibl similar differ bodi weight chang behavior sever metabol variabl bl sv strain respons high fat diet hfd use absoluteidq p kit found week hfd induc signific bodi weight gain sv bl mice besid sv mice display anxieti like behavior open field test metabolit profil reveal sv mice higher level circul branch chain amino acid even amplifi hfd hfd also induc decreas glycin spermidin oh prolin level sv mice although acylcarnitin ac domin baselin condit sv strain strain signific stronger ac reduc effect hfd moreov sv mice higher level lipid baselin condit hfd caus pronounc alter lipid profil bl mice taken togeth result show bl line better adapt abund fat intak | D059305;D013095 | T061;T109;T123 |
36,232,981 | divers extracellular vesicl human follicular fluid morpholog analysi quantif oocyt microenviron constitut follicular fluid ff key optim develop femal gamet composit reflect physiolog state ovarian follicl particular ff contain huge divers extracellular vesicl specif women way semin plasma men describ compar morpholog aspect broad subcategori human ff relat extracellular vesicl ev ev particip physiolog patholog process potenti applic diagnost therapeut ev isol ff involv differ biolog function relat follicular growth oocyt matur embryo develop howev knowledg morpholog ff deriv ev limit main due sub micromet size intrins limit method appli character aim studi provid comprehens morpholog descript ev ff healthi subject quantif ev separ realiz centrifug comparison ev yield obtain differenti centrifug one step ultracentrifug cryo transmiss electron microscopi use reveal morpholog size phenotyp ev dynam light scatter dls nanoparticl track analysi nta use quantifi analyz size distribut centrifug step perform comprehens inventori human follicular fluid ev show human ff contain huge divers ev studi bring novel insight ev normal ff provid refer studi ev ovarian diseas | D000067128;D015571 | T026;T031 |
36,232,980 | resveratrol mitig oxygen glucos depriv induc inflamm nlrp inflammasom oxid stress neuron cultur oxygen glucos depriv ogd produc hypoxia induc neurotox matur vitro model hypox cell damag activ amp activ protein kinas ampk regul downstream pathway substanti increas bioenergi product may key player physiolog energi also shown play role regul neuroprotect process resveratrol effect activ ampk indic may therapeut potenti neuroprotect agent howev mechan resveratrol achiev benefici effect sh syy cell expos ogd induc inflamm oxid stress gelatin scaffold remain unclear therefor present studi investig effect resveratrol gelatin scaffold cell understand neuroprotect effect nf b signal nlrp inflammasom oxid stress ogd condit show resveratrol improv express level cell viabil inflammatori cytokin tnf il il nf b signal nlrp inflammasom ogd increas addit resveratrol rescu oxid stress nuclear factor erythroid relat factor nrf nrf downstream antioxid target gene eg sod gpx gsh catalas ho treatment resveratrol signific normal ogd induc chang sh syy cell inflamm oxid stress oxid defens gene express howev resveratrol protect effect affect ampk antagonist compound c block find improv understand mechan ampk depend protect effect resveratrol ogd induc inflamm oxid stress mediat cerebr ischem stroke condit | D009447;D018696 | T191;T169;T121 |
36,232,979 | mammari enrich transcript factor synerg activ wap super enhanc mammari gland develop super enhanc larg cluster enhanc critic cell type specif develop previous studi mammari specif super enhanc high enrich activ enhanc mark hkac mediat med mammari enrich transcript factor elf nfib stata gr identifi genom mammari epithelium lactat mice howev trigger mechan mammari specif super enhanc molecular interact key transcript factor clear elucid studi investig vivo protein protein interact major transcript factor activ mammari specif super enhanc mammari epitheli cell elf strong interact nfib weak interact stata show modest interact med gr pattern unlik non mammari cell investig role key transcript factor initi activ mammari specif wap super enhanc use crispr cas genom edit introduc singl combin mutat transcript factor bind site pioneer enhanc wap super enhanc mice elf stata play key role ignit wap super enhanc activ intact transcript factor complex requir full function super enhanc studi demonstr mammari enrich transcript factor within protein complex interact differ intens synerg activ wap super enhanc find provid import framework understand regul cell type specif develop | D004742;D007774 | T042;T123;T114 |
36,232,978 | intracrani virotherapi canin hemangioma intracrani hemangioma rare neoplast lesion dog usual appear life threaten symptom treatment choic tumor resect howev complet resect rare achiev patient prognosi therefor usual worsen due tumor progress adjuv treatment requir control diseas oncolyt virus innov approach lyse tumor cell induc immun respons report intratumor inocul icocav oncolyt adenovirus canin intracrani hemangioma adjuv treatment incomplet tumor resect canin patient show side effect tumor volum decreas month treatment measur magnet reson imag use volumetr criteria progress diseas detect month new dose icocav administ patient die month first inocul oncolyt adenovirus furthermor tumor infiltr immun cell increas number viral administr suggest tumor microenviron activ increas number infiltr immun cell long surviv time absenc side effect suggest icocav could safe effect treatment explor novel therapi canin hemangioma | D006391;D009369;D050130;D050504 | T191;T061;T005 |
36,232,977 | human serum albumin misfold age diseas age depend conform stabil human serum albumin determin method fluoresc bilay liposom assay pre heat c albumin sera year old healthi subject exhibit hydrophob effect liposom made liposom membran phospholipid suscept hydrolysi lipolyt enzym phospholipas contrast albumin sera year old individu stabl c display increas hydrophob effect liposom result suggest albumin sera year old subject easili convert misfold form protein structur alter compar albumin sera year old individu misfold albumin lose abil carri normal homeostat function may promot alter membran integr inflammatori condit howev investig limit includ lack test sera larg number individu across broad rang age valid preliminari observ age depend differ albumin stabil interact liposom | D000375;D008081;D017510;D000075462 | T116;T121;T109;T040;T044;T033 |
36,232,976 | corner stabil compar molecular dynam simul studi explor mechan stabil super secondari structur corner type autonom outsid protein globul maintain aqueous environ molecular dynam md studi determin behavior divers larg set non homolog corner structur various origin focus geometr paramet chang gyrat radius solvent access area major conform lifetim torsion angl number hydrogen bond ultim set corner structur character root mean squar deviat rmsd less chang gyrat radius preserv amino acid residu posit within allow region ramachandran map studi structur retain topolog throughout md experi thus corner structur found rather stabl per se water environ ie without rest protein molecul act nucleus readi made build block protein fold corner also consid independ object studi field structur biolog | D056004;D014867 | T121;T044;T066;T197 |
36,232,975 | minicircl deliveri neural retina gene therapi approach non viral gene therapi potenti overcom sever shortcom viral vector base therapeut method vivo plasmid deliveri develop recent year increas effici non viral gene transfer yet improv still need made improv translat capac gene therapi advanc inherit retin diseas particular promin recent decad overcom physic physiolog barrier present eye remain key obstacl field non viral ocular drug deliveri minicircl circular doubl strand dna vector contain express cassett devoid bacteri dna therebi limit risk innat immun respons induc element date extens use pre clinic studi yet remain viabl vector option treatment inherit retin diseas explor potenti minicircl dna deliveri neural retina gene therapi approach consid advantag minicircl gene therapi vector well review challeng involv optimis deliveri neural retina | D015316;D012164 | T061;T047 |
36,232,974 | insight four nac transcript factor involv grain develop respons moder heat triticea tribe nac nam apic meristem ataf arabidopsi transcript activ factor cuc cup shape cotyledon among largest transcript factor famili plant involv plethora physiolog mechan studi focus four nac gene previous identifi bread wheat specif grain express could consid candid gene yield improv climat chang use silico analys triticum aestivum grain nac tagnac ortholog cereal speci identifi conserv protein motif identifi triticea express tagnac einkorn tmgnac studi respons moder heat stress grain develop show similar express pattern acceler cell divis stage heat stress conserv structur found promot triticea amp nbsp gnac ortholog absent poacea speci specif model promot structur triticea propos base presenc key cis element involv regul seed develop hormon regul respons biotic abiot stress conclus gnac gene could play central role regul grain develop triticea tribe particular accumul storag protein well respons heat stress could use candid gene breed | D017360;D014157 | T123;T116;T002 |
36,232,973 | liposom formul tumor target drug deliveri use radiat therapi target deliveri drug therapeut agent intern extern trigger use control acceler releas liposom carrier number studi relat util energi therapeut x ray trigger synthes liposom trigger ioniz radiat rtls releas therapeut payload liposom compos natur egg phosphatidylethanolamin pe distearoyl sn glycero phosphocholin dspc cholesterol disteroyl sn glycero phosphoethanolamin n methoxi polyethylen glycol dspe peg mean size rtl rang nm measur nanoparticl track analysi nta trigger mechan organ halogen chloral hydrat known generat free proton upon exposur ioniz radiat proton liber drop intern ph liposom promot destabil lipid bilay escap liposom content proof principl studi assess rtl radiat releas fluoresc tracer upon exposur low ph extracellular environ exposur x ray irradi biodistribut imag irradi demonstr preferenti uptak releas liposom cargo site local tumor irradi final potent metabolit common use chemotherapi irinotecan sn load rtl along near infrar nir fluoresc dye imag studi measur tumor cell cytotox alon combin radiat exposur vitro vivo fulli load rtls found increas tumor cell kill radiat vitro enhanc tumor growth delay vivo three iv inject combin three gy local tumor radiat exposur compar either treatment modal alon | D008081;D009369 | T191;T109 |
36,232,972 | switch photocatalyt tyrosinehistidin label applic photocatalyt proxim label weak transient protein interact involv dynam biolog respons import research subject howev method elucid interact lack proxim label promis techniqu label transient ligand bind protein protein protein interact partner analyt via irrevers coval bond expand chemic tool proxim label requir analyz interactom develop sever photocatalyt proxim label reaction mediat two differ mechan found numer dye molecul function catalyst protein label also identifi catalyst select modifi tyrosin histidin residu evalu mechan model experi use halotag perform demonstr photocatalyt proxim label found atto catalyz label singl electron transfer bodipi catalyz label singlet oxygen catalyz proxim label cell | D006639;D014443 | T121;T123;T116 |
36,232,971 | glutam acid poli glutam acid enhanc heat resist chines cabbag brassica rapa l ssp pekinensi improv carotenoid biosynthesi photosynthesi ros signal heat stress one common agrometeorolog risk crop product middl lower reach yangtz river china studi aim investig whether glutam acid glu poli glutam acid pga biostimul improv thermotoler cool season chines cabbag brassica rapa l ssp pekinensi crop prime glu mm pga mgl conduct third leaf stage appli daili foliar spray day day heat stress c h light c h dark coupl morpho physiolog biochem analys transcriptom glu pga prime chines cabbag heat stress examin rna seq analysi result show thermotoler confer glu pga prime associ increas paramet veget growth gas exchang chlorophyl fluoresc compar control dri weight plant treat glu pga increas respect glu pga applic also signific increas content total chlorophyl carotenoid respect addit glu pga prime plant mark inhibit level malondialdehyd electrolyt leakag super oxid anion radic accompani enhanc activ level superoxid dismutas sod catalas cat ascorb peroxidas apx peroxidas pod enrich analysi kyoto encyclopedia gene genom kegg categori within differenti express gene deg function cluster rna seq data indic express level gene dna replic dna repair system linol acid metabol cystein methionin metabol glutathion metabol purin pyrimidin metabol carotenoid biosynthesi plant pathogen interact common regul glu pga prime glu treatment enhanc express level gene involv aliphat glucosinol oxocarboxyl acid pga treatment activ carotenoid cleavag reaction synthes abscis acid taken togeth glu pga great potenti preadapt chines cabbag seedl heat stress glu effect pga | D001937;D029741 | T168;T002 |
36,232,970 | quantit proteom medium size extracellular vesicl enrich plasma lacunar infarct discoveri prognost biomark lacunar infarct laci subtyp acut ischem stroke poor mid long term prognosi due recurr vascular event incid dementia difficult predict use exist clinic data herein aim discov blood base biomark laci complementari prognost tool convalesc plasma collect forti five patient follow non disabl laci along seventeen match control subject patient follow prospect five year record occurr advers outcom group accord ie laci advers outcom laci recurr vascular event laci cognit declin without recurr vascular event medium size extracellular vesicl mev isol pool plasma four group analyz stabl isotop label lc msms fdr lt quantifi protein show signific chang least one laci group compar match healthi control system analysi reveal major element mev proteom differ proteom small size extracellular vesicl obtain pool plasma alter mev protein laci patient most reduc abund major shortlist mev protein link common studi biolog process coagul fibrinolysi inflamm instead link oxygen glucos depriv endo lysosom traffick glucos transport iron homeostasi dataset provid web base data resourc facilit meta analysi data integr target larg scale valid | D000067128;D000083242;D059409 | T026;T047 |
36,232,969 | new crispr tool correct pathogen mutat usher syndrom inherit retin degener lead caus blind uk signific advanc made tackl issu recent year pioneer fda approv gene therapi treatment luxturna target loss function mutat rpe gene howev remain notabl shortcom form gene replac therapi particular lack viabil gene sequenc exceed kb adeno associ virus aav packag limit toxic gain function mutat usha gene kb instanc larg aav deliveri safe effect vehicl capabl transduc photoreceptor cell gene replac therapi usher syndrom clinic genet heterogen deaf blind syndrom autosom recess inherit usha gene encod protein usherin localis photoreceptor cilium cochlear hair cell mutat usha gene caus usher syndrom type ii ush common subtyp usher syndrom focus review date research unabl creat effici safe edit tool small enough fit insid singl aav vector deliveri human cell articl review potenti crispr technolog deriv bacteri defenc mechan overcom challeng deliv tool precis edit correct small insert delet base transit usha without need deliv full length gene ultra compact therapi could make stride combat signific caus blind young peopl | D012162;D052245 | T047;T046 |
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