PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,968 | wheat flour base edibl film effect gluten rheolog properti structur film characterist work investig structur rheolog properti film perform wheat flour hydrocolloid comparison wheat starch ws gluten blend system incorpor gluten could decreas inter chain hydrogen bond starch therebi reduc viscos solid like behavior film form solut improv frequenc depend reduc surfac smooth compact water vapor barrier perform mechan properti film howev good compat starch gluten could improv densiti self similar structur process film form solut film perform film base wheat flour show denser film structur better mechan properti thermal stabil wors base ws gluten blend knowledg gain studi could provid guidanc develop flour base edibl packag materi therebi promot energi conserv environment protect | D000080122;D005433 | T168;T073 |
36,232,967 | genom wide analysi myb relat transcript factor famili pepper function studi camyb involv capsaicin biosynthesi chili pepper import econom veget worldwid myb famili gene member play import role metabol process plant growth develop studi pepper myb relat member identifi group nine subfamili accord phylogenet relationship addit total collinear gene pair identifi pepper tomato pepper arabidopsi tomato arabidopsi respect perform promot cis element analysi show camyb relat member may involv multipl biolog process growth develop secondari metabol circadian rhythm regul express pattern analysi indic camyb signific enrich fruit placenta suggest gene may involv capsaicin biosynthesi vig confirm camyb critic biosynthesi capsaicin placenta subcellular local studi reveal camyb local nucleus basi yeast one hybrid dual luciferas report assay found camyb direct bind promot capsaicin biosynthesi gene activ transcript therebi regul capsaicin biosynthesi summari systemat identifi member camyb relat famili predict possibl biolog function reveal camyb critic transcript regul capsaicin biosynthesi work provid foundat studi camyb relat famili pepper growth develop | D017360;D014157 | T123;T116;T002 |
36,232,966 | oxid stress dna damag marker colorect cancer oxid stress os inflamm known play import role chronic diseas includ cancer specif colorect cancer crc main object studi explor diagnost potenti os marker patient crc may translat earli diagnosi diseas compar result group healthi control assess whether signific differ addit explor possibl correl presenc tumor tumor stage anemia inflammatori marker use clinic practic studi includ patient crc healthi control follow os marker analyz catalas cat reduc glutathion gsh oxid glutathion gssg serum oxo dihydro deoxyguanosin oxodg f isoprotan urin f isop tumor marker cea ca anemia marker hemoglobin hematocrit medium corpuscular volum inflammatori marker leukocyt neutrophil nl index platelet fibrinogen c reactiv protein crp il also determin comparison mean patient control reveal high signific differ os marker increas prooxid marker gssg gssggsh ratio oxodg f isop decreas antioxid marker cat gsh tumor inflammatori marker except crp correl posit gssg gssggsh ratio oxodg f isop negat cat gsh view result obtain os marker may constitut use tool earli diagnosi crc patient | D000975;D015179 | T121;T191;T123;T044;T039 |
36,232,965 | saccharomyc cerevisia model system eukaryot cell biolog cell cycl control dna damag respons yeast saccharomyc cerevisia use bread make beer brew thousand year addit eas manipul well annot genom expans molecular toolbox strong conserv basic eukaryot biolog also make prime model eukaryot cell biolog genet review discuss characterist made yeast extens use model organ specif focus dna damag respons pathway prime exampl research cerevisia help elucid high conserv biolog process addit also highlight differ dna damag respons cerevisia human discuss challeng use cerevisia model system | D001686;D012441 | T038;T004;T070 |
36,232,964 | character abc transport g subfamili pomegran function analysi pgrabcg atp bind cassett subfamili g abcg protein play import role plant growth develop transport metabolit across cell membran date genet characterist potenti function pomegran abcg protein pgrabcg remain larg unknown studi found pgrabcg divid five group accord phylogenet analysi group ii iii iv member half size protein group v member full size protein pgrabcg pgrabcg pgrabcg high express inner seed coat low express level outer seed coat express level three pgrabcg gene inner seed coat hard seed pomegran dabenzi higher soft seed pomegran tunisia addit express three pgrabcg gene high correl express gene involv lignin biosynthesi hormon signal pathway evolut pgrabcg present high similar trend origin evolut lignin biosynthesi land plant evolut ectop express pgrabcg arabidopsi promot plant growth lignin accumul compar wild type plant meanwhil express level lignin biosynthesi relat gene cad ch prx cytokinin respons marker gene arr arr signific upregul transgen plant suggest potenti role pgrabcg promot plant growth lignin accumul taken togeth find provid insight characterist evolut pgrabcg also shed light potenti function pgrabcg seed hard develop | D017360;D000079702 | T121;T109;T002 |
36,232,963 | eosinophil infiltr sino atrial node sudden cardiac death caus long qt syndrom sudden death defin unexpect death healthi person occur within first hour onset symptom within h victim last seen aliv case rare deleteri variant gene associ inherit cardiac disord provid high probabl explan fatal event report case year old obes woman lost conscious sudden public place pronounc dead hospit admiss clinic autopsi show inconclus gross examin histopatholog analysi eosinophil inflammatori focus interstiti fibrosi sino atrial node found molecular autopsi reveal intron variant kcnq gene c g gt classifi like pathogen long qt syndrom accord guidelin provid american colleg medic genet genom therefor mani anomali could play role causat sudden death extrem obes cardiac anomali kncq variant case depict difficult interpret rare cardiac structur abnorm subject carri rare variant respons inherit arrhythm disord challeng forens pathologist make causal infer determin unexpect deceas | D008133;D012849 | T047;T023;T033 |
36,232,962 | molecular mechan under patholog therapeut role pericyt atherosclerosi pericyt multipot mesenchym stromal cell play activ role angiogenesi vessel stabilis matur remodel blood flow regul abl tran differenti cell mesenchym lineag review summaris recent data demonstr pericyt play key role pathogenesi develop atherosclerosi pericyt involv lipid accumul inflamm growth vascular atherosclerot plaqu decreas pericyt coverag endotheli pericyt dysfunct associ intraplaqu angiogenesi haemorrhag calcif cholesterol cleft deposit time pericyt use novel therapeut target promot vessel matur stabil thus reduc plaqu vulner final discuss recent studi explor effect treatment pericyt mediat anti atherosclerot anti inflammatori anti apoptot effect | D050197;D058226 | T031;T047;T046;T020 |
36,232,961 | relat abund lipid metabolit spermatozoa across three compart male fertil manifest quantiti progress motil spermatozoa negat impact obes dyslipidaemia metabol diseas howev relat distribut lipid spermatozoa two compart suppli lipid spermatogenesi semin fluid blood serum studi hypothesis alter avail lipid blood serum semin fluid may affect lipid composit progress motil sperm men age year median rang bmi kgm preliminari investig subfertil recruit nhs clinic men provid sampl serum semen subject strict accept criteria analysi spermatozoa count motil blood serum n spermatozoa n semin fluid n frozen batch lipidom analysi spermatozoa semin fluid compar lipid composit show mark differ serum lipidom spermatozoa demonstr high abund ceramid long chain fatti acid c certain phospholipid sphingomyelin plasmalogen phosphatidylethanolamin low abund phosphatidylcholin cholesterol triglycerid men spermatozoa low progress motil evid fewer concentr gradient mani lipid speci blood serum spermatozoa compart spermatozoa abund multipl lipid speci like contribut key cellular function lipid metabol show reduc regul compart men spermatozoa reduc progress motil | D012661;D013081 | T043;T031 |
36,232,960 | hepatocyt deriv prostaglandin e modul macrophag type polar via mtor npc axi regul cholesterol transport lysosom endoplasm reticulum hepat b virus x protein relat nonalcohol steatohepat lipid metabol dysregul liver inflamm report associ nonalcohol steatohepat nash under mechan remain unclear hepat b virus x protein hbx risk factor nash base metabolom transcriptom screen public databas analysi found hbx express hepatocyt deriv prostaglandin e pge induc macrophag polar imbal via prostaglandin e receptor ep vitro ex vivo vivo model reveal type polar macrophag induc endoplasm reticulum oxidoreductas like protein ero depend endoplasm reticulum stress associ hbx relat hepat nash phenotyp mechanist hbx promot niemann pick type c npc oxysterol bind protein relat protein orp mediat cholesterol transport lysosom endoplasm reticulum via mammalian target rapamycin mtor activ studi provid novel basi screen potenti biomark macrophag mtor cholesterol homeostasi polar regulatori signal pathway evalu target intervent hbx associ nash | D065626;D000072376 | T047;T109;T123 |
36,232,959 | receptor advanc glycat end product promot activ alveolar macrophag nlrp inflammasometxnip axi acut lung injuri role thioredoxin interact protein txnip receptor advanc glycat end product rage depend mechan nod like receptor famili pyrin domain contain nlrp inflammasom driven macrophag activ acut lung injuri underinvestig cultur thp macrophag treat rage agonist sa without rage antagonist cytokin releas intracytoplasm product reactiv oxygen speci ros assess respons small interf rna knockdown txnip nlrp lung express txnip nlrp alveolar level il sa measur mice acid induc lung injuri without administr rage inhibitor alveolar macrophag patient acut respiratori distress syndrom mechan ventil control analyz use fluoresc activ cell sort vitro rage promot cytokin releas ros product macrophag upregul nlrp txnip mrna express respons sa txnip inhibit downregul nlrp gene express rage mediat releas il macrophag vitro vivo rage nlrp txnip lung express upregul experiment acut lung injuri phenomenon revers rage inhibit number cell express rage nlrp txnip among specif subpopul cdcdcd pro inflammatori alveolar macrophag higher patient lung injuri studi provid novel proof concept complex rage txnip nlrp interact macrophag activ acut lung injuri | D055371;D058847 | T123;T116;T037 |
36,232,958 | human rad protein form amyloid like aggreg vitro rad central protein homolog recombin dna repair process maintain genom stabil ensur accur repair doubl strand break dsbs work assess amyloid properti rad vitro bacteri cur depend amyloid generat c dag system resist ionic deterg stain amyloid specif dye polar microscopi transmiss electron microscopi tem x ray diffract method use evalu properti structur rad aggreg purifi human rad protein form deterg resist aggreg vitro unbranch cross fibrillar structur typic amyloid stain amyloid specif dye congo red stain rad aggreg demonstr birefring polar light rad fibril produc sharp circular x ray reflect demonstr cross structur cytoplasm aggreg rad observ cell cultur overexpress rad demonstr key protein maintain genom stabil rad amyloid properti vitro c dag system discuss possibl biolog relev observ | D003902;D051135 | T116;T073;T120;T121;T126 |
36,232,957 | novel biomark therapeut target melanoma malign melanoma one common cancer world diseas earli stage treatment involv surgeri advanc stage howev treatment option scarc paradigm shift advanc melanoma treatment introduct immunotherapi target therapi understand molecular pathway patholog counterpart help identifi specif biomark lead develop specif target therapi review briefli present marker relev melanoma treatment | D008545;D012878 | T191 |
36,232,956 | bioengin approach fight orthoped biomateri relat infect one serious complic follow implant orthoped biomateri develop infect orthoped implant relat infect entail clinic problem patient suffer also caus burden healthcar care system addit age world popul particular develop countri led increas popul year signific vulner popul segment insofar biomateri use concern implant materi high suscept bacteri fungal colon consequ infect microorgan often opportunist take advantag weaken bodi defens implant surfac tissu interfac attach tissu implant surfac instig biofilm format subsequ develop infect establish biofilm lead tissu destruct system dissemin pathogen dysfunct implantbon joint lead implant failur moreov contamin implant reservoir infect surround tissu microorgan protect therefor biofilm increas pathogenesi infect sinc structur offer protect host defens antimicrobi therapi addit rapid emerg bacteri strain resist antibiot prompt develop new altern approach prevent control implant relat infect sever concept approach develop obtain biomateri endow anti infect properti review sever anti infect strategi base biomateri engin describ discuss term design fabric mechan action benefit drawback prevent treat orthopaed biomateri relat infect | D000890;D009985 | T121;T091 |
36,232,955 | novel amoxicillin load sericin biopolymer nanoparticl synthesi optim antibacteri wound heal activ infect wound major threat among diabet patient technolog advanc current increas number new adjunct therapi may potent agent speed recoveri lower amput rate limit infect recurr novel formula promis antibacteri activ name sericinpropolisamoxicillin nanoparticl assess potent treatment infect wound normal diabet rat skin wound heal effici assess wound heal score bacteri load assess histolog examin reveal upon use sericinpropolisamoxicillin nanoparticl complet wound heal success achiev day postinjuri nondiabet diabet rat respect howev bacteri load induc infect wound extrem low cfuml day post treatment histolog studi reveal dermi organ new matrix deposit matur collagen fiber observ among treat anim group present studi first preclin studi report import silk sericin form nano sericinpropoli load amoxicillin effect treatment bacteri wound infect | D003921;D053758;D011429;D047030 | T050;T116;T073;T121;T123 |
36,232,954 | anticanc properti plectranthus ornatus deriv phytochem induc apoptosi via mitochondri pathway sinc cancer treatment radio chemotherapi link safeti concern need new altern anticanc drug compound isol plant repres promis candid current studi investig anticanc featur haliman r e acetoxyhalima dien oic acid hal labdan diterpen diacetoxi r epoxi labden one plec forskolin like mixtur di acetylforskolin di acetyl deoxyforskolin mrc isol plectranthus ornatus mcf fadu cancer cell line cytotox assess mtt assay ros product di chloro dihydro fluorescein diacet assay dcfh red mitochondri superoxid indic mitosox mitochondri membran potenti mmp fluoresc probe jc tetrachloro tetraethylbenzimidazolylcarbocyanin iodid addit relat amount mitochondri dna mtdna determin use quantit real time pcr qrt pcr damag mitochondri dna mtdna nuclear dna ndna semi long run quantit real time pcr slr qrt pcr gene express determin use revers transcript qpcr caspas activ fluoresc assess assess general vivo toxic determin brine shrimp lethal bioassay studi hal plec found cytotox effect mcf ic gml ic gml fadu ic gml ic gml cancer cell line two test cancer cell line phytochem increas ros product mitochondri damag nd nd gene region reduc mmp mitochondri copi number also chang express pro anti apoptot gene bax bcl tp cas cas cas apaf mcl studi demonstr increas caspas activ test cancer cell line addit show toxic effect vivo test compound test potenti mechan action may associ induct apoptosi mcf fadu cancer cell via mitochondri pathway howev vivo research need understand mechan action potenti compound | D000970;D004224;D031346 | T121;T109;T002 |
36,232,953 | improv adipos tissu function singl anastomosi duodeno ileal bypass sleev gastrectomi sadi diet induc obes bariatr surgeri recogn safest effect procedur control type diabet td obes care select patient aim present studi compar effect sleev gastrectomi sg singl anastomosi duodenoil bypass sg sadi metabol profil diet induc obes rat total four week old male wistar rat submit surgic intervent sham oper sg sadi month fed high fat diet bodi weight metabol profil express molecul involv control subcutan white scwat brown bat beig beat adipos tissu function analyz sadi surgeri associ signific decreas amount total fat pad p lt well better control lipid glucos metabol compar sg counterpart improv express molecul involv fat brown scwat control bat beat differenti function observ follow sadi togeth find provid evid enhanc metabol improv continu durabl sadi compar sg reli least part improv beat phenotyp function | D003924;D009767 | T047 |
36,232,952 | human papillari reticular fibroblast show distinct function tumor behavior organotyp cultur mimick melanoma hnscc human dermi morpholog divid upper papillari lower reticular dermi previous demonstr papillari pfs reticular rfs fibroblast show distinct morpholog gene express profil moreov differ affect tumor invas epitheli mesenchym transit emt vitro organotyp cultur cutan squamous cell carcinoma cscc studi examin distinct effect pfs rfs extrapol epithelialnon epitheli tumor melanoma head neck squamous cell carcinoma hnscc end full thick model ftms establish melanoma hnscc cell line um scc um scc togeth either pfs rfs dermi interplay tumor cell differ fibroblast investig observ test tumor cell line show signific stronger invas rf ftms compar pf ftms addit rf ftms demonstr tumor cell prolifer emt induct basement membran disrupt interest rfs start express cancer associ fibroblast caf biomark sma indic reciproc interact eventu transit rfs caf collect melanoma hnscc ftms interact rfs tumor cell promot emt invas accompani differenti rfs caf | D002294;D006258;D008545;D012878 | T191 |
36,232,951 | metabol heterogen brain tumor cell proneur mesenchym origin brain tumor initi cell btic proneur mesenchym origin contribut high malign phenotyp glioblastoma gb resist current therapi btic differ subtyp challeng oxid phosphoryl oxpho inhibit metformin assess differenti effect metabol intervent key resist featur wherea mesenchym btic vari accord invas general glycolyt less respons metformin proneur btic less invas catabol glucos via pentos phosphat pathway respond better metformin target glycolysi may promis approach inhibit tumor cell mesenchym origin wherea proneur cell respons oxpho inhibit futur clinic trial explor metabol intervent account metabol heterogen brain tumor | D001932;D005909;D008687 | T191;T109;T121 |
36,232,950 | genom wide analysi express profil glutathion reductas gene famili oat avena sativa indic respons abiot stress seed imbibit abiot stress disturb plant cellular redox homeostasi inhibit seed germin plant growth crucial limit crop yield glutathion reductas gr import compon ascorb glutathion asa gsh cycl involv multipl plant metabol process present studi grs sativa asgr select explor molecular character phylogenet relationship rna express chang seed imbibit abiot stress seven asgr gene identifi map six chromosom c subgenom phylogenet analysi subcellular local asgr protein divid two sub famili asgr asgr predict main locat cytoplasm mitochondrion chloroplast cis element relev stress hormon respons distribut promot region asgr tissu specif express profil show asgr gene high express root leav seed asgr gene high express leav seed asgr asgr gene show decreas increas express trend seed germin non stress condit addit respons drought salt cold copper h age treatment quit differ seed imbibit among seven asgr gene asgr asgr c asgr asgr respond signific especi drought age h stress studi laid ground function character gr improv oat stress toler seed vigor | D018554;D006861 | T121;T130;T002;T197 |
36,232,949 | prolong exposur high temperatur inhibit shoot primari root secondari growth panax ginseng high temperatur one signific abiot stress reduc crop yield qualiti inhibit plant growth develop global warm recent increas frequenc heat wave negat impact agricultur field despit numer studi heat stress respons signal transduct model plant speci molecular mechan under thermomorphogenesi panax ginseng remain larg unknown investig high temperatur respons ginseng phenotyp molecular level primari shoot growth secondari root growth ginseng plant signific reduc high temperatur histolog analysi reveal decreas shoot root growth caus decreas cell elong cambium stem cell activ respect analysi p ginseng rna seq data reveal heat stress repress stem root growth close relat chang photosynthesi cell wall organ cell wall loosen abscis acid aba jasmon acid ja signal reduct light dark reaction photosynthesi result defect starch granul develop storag parenchym cell main tap root thus combin bioinformat histolog analys show high temperatur signal pathway integr crucial biolog process repress stem root growth ginseng provid novel insight heat stress respons mechan p ginseng | D005894 | T002 |
36,232,948 | insight metabol respons lactiplantibacillus plantarum ccfm upon patulin exposur patulin pat common mycotoxin food industri found appl product particular consumpt food feed contamin pat caus acut chronic toxic human anim lactiplantibacillus plantarum ccfm probiot strain effect degrad pat pbs food system studi found concentr pat mgl mrs medium decreas first stage ccfm growth chang consist first order degrad kinet model meanwhil regul oxid stress l plantarum ccfm respons pat exposur metabol chang occur pat degrad investig degre intracellular damag attenu h exposur compar h meanwhil metabolom data show signific differ metabolit screen intracellular strain h h pat stress mgl respect result pathway enrich analysi suggest purin metabol pathway signific enrich h h howev consist perform antioxid system chang lactiplantibacillus diminish increas time pat exposur therefor studi help explain mechan pat degrad l plantarum ccfm | D027845;D010365;D019936 | T002;T007;T131;T109;T168 |
36,232,947 | studi biolog activ admet relat properti salicylanilid base peptidomimet seri eleven benzyl intermedi eleven target compound deriv salicylanilid test staphylococcus aureus atcc enterococcus faecali atcc refer strain three clinic isol methicillin resist aureus mrsa three isol vancomycin resist e faecali addit compound evalu mycobacterium tuberculosi hra smegmati atcc vitro cytotox compound assess use human monocyt leukemia cell line thp lipophil prepar compound experiment determin correl biolog activ benzyl intermedi found complet biolog inact final eleven compound accord number amid group molecul eight diamid three triamid inact chloro hydroxi n methylsulfanyl oxo trifluoromethyl phenyl amino butan yl benzamid e chloro hydroxi n methyl oxo trifluoromethyl phenyl amino pentan yl benzamid f show broadest spectrum activ test speciesisol compar use standard ampicillin isoniazid six diamid show high antistaphylococc activ mic rang three diamid show anti enterococc activ mic rang activ f e tuberculosi smegmati mic respect activ compound microbicid observ connect linker chlorsalicyl cf anilid core must substitut bulki andor lipophil chain isopropyl isobutyl thiabutyl chain anticanc activ thp cell ic rang gt increas increas lipophil | D055624;D009169;D057786 | T007;T121 |
36,232,946 | homozyg crisprca knockout generat novel function activ exon skip xpa variant melanoma cell defect dna repair pathway associ improv respons immun checkpoint inhibit ici particular patient nucleotid excis repair ner defect diseas xeroderma pigmentosum xp respond impress well ici treatment recent melanoma patient pretherapeut xp gene express predict anti program cell death pd ici respons under mechan find still reveal therefor use crisprca disrupt xpa melanoma cell result subclon cell line investig sanger sequenc base genet sequenc candid xpa exon select analyz immunoblot immunofluoresc hcr mtt assay xpa exon establish homozyg cdelg palf compound heterozyg cdelgcinsg palf pagf cell line xpa exon generat compound heterozyg mutat cell line cdelttgcdelga piddelinsnpdhf better perform homozyg heterozyg mutat exon cell dna damag repair hcr post uv c cell surviv mtt associ express novel xpa protein variant result studi serv fundament basi investig immunolog consequ xpa disrupt melanoma | D008545;D014983;D051760 | T191;T116;T123;T019 |
36,232,945 | phosphoryl signal downstream dopamin receptor emot behavior associ prefer avoid dopamin regul emot behavior includ reward avers behavior mesolimb dopaminerg pathway project dopamin neuron ventral tegment area nucleus accumben nac protein phosphoryl critic intracellular signal pathway physiolog function regul neurotransmitt brain previous studi demonstr dopamin stimul phosphoryl intracellular substrat receptor ion channel transcript factor regul neuron excit synapt plastic dopamin receptor also establish novel databas call kanpho provid inform phosphoryl signal downstream monoamin identifi kinas substrat screen method includ dopamin addit report literatur recent advanc proteom techniqu enabl us clarifi mechan dopamin control reward avers behavior signal pathway nac review discuss intracellular phosphoryl signal regul dopamin two emot behavior | D004298;D017557 | T121;T023;T109;T123 |
36,232,944 | analysi aroyl chloro methylphenyl thiourea hybrid potent ureas inhibitor synthesi biochem evalu comput approach ureas amidohydrolas enzym respons fatal morbid human bodi cathet encrust encephalopathi peptic ulcer hepat coma kidney stone format mani other recent year scientist devot consider effort quest effici ureas inhibitor pharmaceut chemistri thiourea skeleton play vital role thus present work focus develop discoveri novel ureas inhibitor report synthesi set aroyl chloro methylphenyl thiourea hybrid aliphat aromat side chain j compound character differ analyt techniqu includ ft ir h nmr c nmr evalu vitro enzym inhibitori activ jack bean ureas jbu found potent anti ureas inhibitor inhibitori activ ic found rang compar standard thiourea ic studi includ densiti function theori dft antioxid radic scaveng assay physicochem properti admet properti molecular dock molecular dynam simul compound found activ standard compound exhibit greatest jbu enzym inhibit ic valu kinet enzym inhibit reveal compound exhibit non competit inhibit ki valu correl dft experi modest homo lumo energi gap biolog data optim recent identifi ureas enzym inhibitor may serv start point futur research develop | D000975;D013890 | T121;T109;T123;T130;T044;T039 |
36,232,943 | multicellular model studi cardiac fibrosi ex vivo model system cardiovascular research becom increas import reduc lab anim use boost person medicin approach integr multipl cell type complex setup add higher level signific model simul intric intercellular communic microenviron vivo cardiac fibrosi repres key pathogenet step multipl cardiovascular diseas ischem diabet cardiomyopathi inde allow inter cellular interact cardiac stromal cell endotheli cell cardiomyocyt andor immun cell dedic system could make ex vivo model cardiac fibrosi even relev moreov cultur system architectur enrich physiolog signific vitro model review provid summari multicellular model studi cardiac fibrosi describ literatur spontan microtissu bioprint construct engin tissu organ chip discuss advantag limit import discoveri physiopatholog cardiac fibrosi well screen novel potenti therapeut molecul report thank system futur develop certain increas translat impact understand modul mechan cardiac fibrosi even | D042783;D023822 | T061;T025 |
36,232,942 | atom scale optim strategi al base layer doubl hydroxid alkali stabil supercapacitor pseudocapacitor materi easili decompos immers alkalin solut long time henc necessari find strategi improv alkali stabil pseudocapacitor materi addit relationship alkali stabil electrochem perform still unclear work seri al base ldh layer doubl hydroxid deriv nico base sulfid prepar correspond alkali stabil electrochem perform analyz alkali stabil coal ldh poor improv effect dope ni ni co ni co al ldh exhibit outstand alkali stabil ni co exhibit extrem poor alkali stabil variabl valenc state co element solubl al alkali solut fundament reason poor alkali stabil coal ldh ni co ni co show outstand electrochem perform three electrod system better ni co indic direct correl alkali stabil electrochem properti sulfid improv electr conduct electrochem activ electrod materi wherea alkali etch suppress occurr electrochem reaction overal work provid clear perspect understand relationship alkali stabil electrochem properti | D000468;D006878 | T197 |
36,232,941 | inhibit glycogen synthas kinas famili bikinin allevi long term effect salin barley crop grown stress condit show restrict growth eventu reduc yield among other brassinosteroid brs mitig effect stress improv plant growth use two barley cultivar differ sensit brs determin lamina joint inclin test barley plant nd unfold leaf spray dilut seri bikinin inhibitor glycogen synthas kinas gsk famili control br signal pathway barley grown salt stress condit start th leaf growth stage phenotyp molecular physiolog chang determin result indic salt toler barley depend sensit brs confirm barley treatment bikinin reduc level phosphoryl form hv bzr activ regul gsk use two barley varieti differ respons salin led identif role br signal photosynthesi activ result suggest salin reduc express gene control br signal pathway moreov result also suggest function analysi gsk famili stress respons tool plant breed order improv crop resist salin stress | D060406;D001467 | T002;T109;T123;T168 |
36,232,940 | hydroxycholesterol induc dysregul cholesterol metabol impair learn memori abil apo transgen mice dysregul brain cholesterol metabol one characterist alzheim diseas ad hydroxycholesterol ohc cholesterol metabolit play essenti role regul cholesterol metabol suggest contribut ad relat cognit deficit howev link ohc cholesterol homeostasi relationship relat ad pathogenesi remain elus month old apo transgen mice inject salin ohc ohc synthetas inhibitor anastrozol an ohcan consecut day cblj mice inject salin use wild type control indic cholesterol metabol synapt structur amyloid learn memori abil measur compar wild type mice apo mice poor memori dysregul cholesterol metabol addit damag brain tissu synapt structur cognit declin higher level observ ohc group moreov cholesterol transport protein atp bind cassett transport abca apolipoprotein e apo low densiti lipoprotein receptor ldlr low densiti lipoprotein receptor relat protein lrp regul cortex ohc treatment level cholesterol metabol relat indic hippocampus consist cortex addit higher serum apolipoprotein apoa level lower serum apo level observ ohc group notabl an partial revers effect ohc conclus alter cholesterol metabol induc ohc involv deposit abnorm brain tissu synapt structur ultim lead memori loss apo transgen mice | D000544;D053327 | T047;T116;T048 |
36,232,939 | yeast ferment rapese meal extract abl reduc inflamm oxid stress caus escherichia coli lipopolysaccharid replac zno caco htx co cultur cell present studi test vitro capac ferment rapese meal extract reduc medicin zno ban eu level onward potenti caus environment pollut develop zn resist gut bacteria rapese meal could import zno substitut antioxidantrad scaveng properti due content bioactiv compound eg polyphenol protein array flow cytometri use detect apoptosi oxid stress product inflammatori signal relat molecul caco goblet ht mtx co cultur cell challeng escherichia coli lipopolysaccharid treat zno frsm lps induc cell death vs control p lt apoptosi ros product overexpress biomark relat inflamm cytokin chemokin oxid stress signal protein compar untreat cell zno effect counteract effect lps cytokin chemokin recov frsm better restor normal protein express cytokin chemokin signal molecul frsm abl mitig negat effect lps might altern zno pig diet | D029688;D029741;D004927;D015034 | T047;T002;T121;T168;T197 |
36,232,938 | pyroptosi insulin resist metabol organ skelet muscl serv optim effect organ balanc glucos homeostasi insulin resist ir skelet muscl break balanc imped glucos uptak caus metabol disord ir skelet muscl caus multipl factor report system low grade inflamm relat skelet muscl ir though molecular mechan need ulterior studi pyroptosi novel inflammatori mediat type cell death recent report pyroptosi associ declin insulin sensit skelet muscl appropri occurr pyroptosi posit elimin pathogen factor wherea excess activ may aggrav inflammatori respons expedit diseas progress relationship pyroptosi ir skelet muscl underlin mechan need illustr role pyroptosi process ir allevi induc non drug intervent exercis also need clarifi paper review describ molecular mechan pyroptosi comb role relev key factor skelet muscl ir aim propos novel theoret basi relationship pyroptosi muscl ir provid new research target improv ir relat diseas | D007333 | T046 |
36,232,937 | mechan foreign bodi respons mitig nitric oxid releas implant glucos biosensor provid real time inform blood glucos fluctuat util accuraci time limit due foreign bodi respons fbr follow insert beneath skin slow releas nitric oxid gasotransmitt inflamm regulatori properti sensor surfac shown dramat improv sensor analyt biocompat reduc overal fbr respons inde work porcin model suggest long implant sensor continu releas even low level inflammatori cell infiltr result collagen densiti lessen studi strong support benefit releas mitig fbr mechan exogen act surround tissu especi condit hyperglycemia remain vagu knowledg would inform strategi refin appropri dosag releas kinet optim therapeut activ studi evalu mediat immun cell mrna express profil local tissu microenviron surround implant sensor function releas diabet implant durat custom porcin wound heal centric multiplex gene array develop nanostr barcod analysi tissu adjac sensor sustain releas abrog implant induc acut chronic fbr modul tissu specif immun chemokin cytokin microenviron result decreas cellular recruit prolifer activ acut chronic phase fbr found sustain releas abrog implant induc acut chronic foreign bodi respons modul mrna encod key immunolog signal molecul pathway includ stat multipl stat target includ mapk irak mmp cxcl condit diabet promot robust fbr implant also control sustain releas | D005547;D064426;D048308 | T116;T037;T020;T123;T072;T197;T126 |
36,232,936 | haloperidol induc immedi earli gene striatopallid neuron requir converg action camppkadarpp mtor pathway antipsychot share common pharmacolog featur antagon dopamin receptor dr abund striatum involv therapeut side effect drug class pharmacolog blockad striatal dr disinhibit dr contain medium size spini neuron msns lead plethora molecular cellular behavior adapt central action antipsychot focus cell type specif dr msns regul striatal immedi earli gene ieg cfos arc zif take advantag transgen mous model pharmacolog approach immunofluoresc analys found haloperidol induc ieg striatum requir synergist activ aa adenosin nmda glutam receptor intracellular signal level found pkadarpp mtor pathway synergist cooper control induct ieg haloperidol confirm expand previous observ result provid novel insight regulatori mechan under molecularcellular action antipsychot striatum | D014150;D006220 | T121;T109;T039 |
36,232,935 | physiolog cooper aquaporin trpv aquaporin among aqp respons transport water across biolog membran import process live organ transient receptor potenti channel trpv cation channel most calcium permeabl also activ osmot stimuli play role number differ function bodi eg develop bone cartilag involv bodi osmoregul generat certain type sensat pain apoptosi earlier studi uterus literatur data arous interest physiolog role cooper aqp trpv review focus co express cooper aqp trpv lung salivari gland uterus adipos tissu len understand cooper aqp trpv may contribut develop new drug candid therapi sever disord eg preterm birth cataract ischemiareperfus induc edema exercis cold induc asthma | D051402;D047928;D050916 | T046;T123;T116;T192 |
36,232,934 | new phospholipas moritella sp jt biochem character crystal applic synthesi phosphatid acid new phospholipas marin moritella sp jt mspld recombin express biochem character optim reaction temperatur ph mspld determin c mspld stabl temperatur lower c c day crystal structur apo mspld resolv function uniqu extra loop segment enzym activ character result indic direct delet fasten extra loop segment introduc disulfid bond result complet loss activ result maximum insert pressur indic delet extra loop segment signific decreas mspld interfaci bind properti phospholipid monolay final mspld appli synthesi phosphatid acid use biphas reaction system optim reaction condit convers rate phosphatid acid reach present research provid foundat reveal structur function relationship enzym | D034221;D010739 | T007;T126;T116 |
36,232,933 | evogliptin direct inhibit inflammatori fibrot signal isol liver cell chronic liver inflamm lead fibrosi cirrhosi hepatocellular carcinoma kupffer cell kc secret proinflammatori fibrogen cytokin respons lipopolysaccharid lps play import role liver inflamm induc hepatocellular damag lps also activ hepat stellat cell induc extracellular matrix deposit studi use isol primari kc primari hepatocyt primari hepat stellat cell hsc investig whether evogliptin direct inhibit inflammatori fibrot signal found evogliptin inhibit lps induc secret induc nitric oxid synthas transform growth factor tgf kc moreov evogliptin inhibit inflammatori mediat releas hepatocyt hepat stellat cell activ induc kc secret cytokin hepatocyt evogliptin also inhibit lps induc express proinflammatori cytokin fibrot tgf addit evogliptin inhibit tgf induc increas connect tissu growth factor level hsc activ find indic evogliptin inhibit inflammatori fibrot signal liver cell also show inhibitori effect evogliptin inflammatori fibrot signal associ induct autophagi | D055513;D008070 | T109;T123;T116 |
36,232,932 | tga transcript factor clade ii negat regul salicyl acid accumul arabidopsi salicyl acid sa hormon modul plant defens induc chang gene express mechan control sa accumul essenti understand defens process tga transcript factor clade ii arabidopsi includ protein tga tga tga known key posit mediat transcript gene pr induc sa applic howev unexpect stress condit induc sa accumul infect avirul pathogen p syringa dcavrrpm uv c irradi result enhanc pr induct plant lack clade ii tgas tga plant increas pr induct accompani enhanc isochorism synthas depend sa product well upregul sever gene involv hormon accumul respons avirul p syringa pr previous shown control sa depend independ pathway therefor enhanc induct pr defens gene accumul sa tga mutant plant consist clade ii tga factor provid negat feedback regul sa depend andor independ pathway togeth result indic tga transcript factor clade ii negat control sa accumul stress condit induc hormon product studi describ mechan involv old actor play new role regul sa homeostasi stress | D017360;D029681 | T116;T002 |
36,232,931 | trail r defici mice protect neurotox effect amyloid trail member tnf superfamili potent induc neuron death neurotox effect trail appear mediat death receptor trail rdr assess role trailtrail r pathway ad relat neurodegener studi impact treatment amyloid upon cell viabil inflamm trail r defici mice trail r demonstr lack trail r protect death cultur trail r mous embryon hippocamp cell treatment either trail consist stereotax inject result blunt caspas activ well reduct jnk phosphoryl increas akt phosphoryl trail r mice moreov lack trail r associ blunt constitut p express mice undergon treatment well decreas phosphoryl form tau gsk protein likewis trail r appear essenti trail mediat neurotox inflamm inde hippocampi trail r mice challeng show slight express microgli iba astrocyt gfap marker along attenu level il tnf nos cox conclus bulk result demonstr constitut lack trail r associ substanti reduct noxious effect provid evid promin role play trail cours relat neurodegener confirm trail system repres potenti target innov ad therapi | D020258;D053220;D014409 | T129;T116;T037;T192 |
36,232,930 | tick born enceph virus rna found frozen goat milk famili outbreak tick born enceph tbe one commonest arthropod born viral diseas middl east europ north asia main reservoir virus compris small rodent domest mammal common tick ixod usual vector clinic spectrum tbe rang mild mening sever meningoencephalomyel diseas lead sever sequela mortal europ even though major case transmit bite infect tick infect ingest contamin milk dairi product farm endem area report report famili outbreak febril diseas initi suggest human human infect earli summertim austria tick born enceph diagnos follow consumpt unpasteuris goat milk virus subsequ detect frozen milk sampl although rare manifest tbe case seri show tbe includ differenti diagnosi outbreak febril diseas care clinic histori refer unpasteur dairi product crucial order prevent diseas spread best prevent measur activ immunis peopl live travel endem area | D004669;D004675;D018884 | T047;T005;T204 |
36,232,929 | effect dss induc ulcer coliti butyr cytochrom p contribut microbiom sever studi indic benefici anti inflammatori effect butyr inflammatori bowel diseas ibd therapi impli attempt increas butyr product gut oral administ dietari supplement gut liver axi howev butyr may reach direct liver influenc drug metabol abil hepat enzym indirect also outcom appli pharmacotherapi focus studi liver microsom cytochrom p cyp mous orthologu human cypa respons metabol metronidazol antibiot use treat ibd find reveal specif pathogen free spf germ free gf mice dextran sulfat sodium dss induc coliti vari mark enzym activ cypa respond differ butyr pre treatment signific decreas cypa activ observ spf mice coliti howev administr butyr prior dss revers inhibit effect phenomenon observ gf mice result highlight import role gut microbiota regul cypa inflammatori condit due role cypa metronidazol metabol phenomenon may impact ibd therapi butyr administr henc bring promis therapeut potenti improv symptom gut inflamm howev possibl interact drug metabol need studi | D002087;D003093;D000069196 | T007;T001;T047;T109 |
36,232,928 | alter hepatocellular carcinoma specif immun respons follow hepat c virus elimin direct act antivir direct act antivir daa recent revolution erad chronic hepat c virus hcv infect howev effect daa develop hepatocellular carcinoma hcc remain unknown therefor present studi aim investig immun respons hcc influenc daa hcv infect patient elucid under mechan compar immun respons differ hcc relat tumor associ antigen taa deriv peptid host immun cell profil week treatment daa hla posit patient relationship differ immun respons phenotyp chang immun cell also examin treatment daa induc four type immun respons taa mark alter host immun cell profil promin reduct frequenc pd cd pd cd cell daa associ enhanc immun respons taa hcv f protein identifi contribut increas frequenc pd cell may decreas erad daa daa alter immun respons patient hcc decreas frequenc pd express cd cd cell | D006528;D006526;D019698;D008113 | T191;T047 |
36,232,927 | unveil target treat postop pain role tnf p mapknf bnav nav pathway mous model incision pain although mous model incision pain broad use mechan under plantar incis induc nocicept fulli understood work investig role na v na v sodium channel nocicept sensit follow plantar incis mice signal pathway modul channel surgic incis made plantar hind paw male swiss mice nocicept threshold assess von frey filament gene express nav nav tnf cox evalu real time pcr dorsal root ganglia drg knockdown mice na v na v produc antisens oligodeoxynucleotid intrathec treatment local level tnf pge immunoenzymat determin incis mice exhibit hypernocicept upregul express nav nav drg antisens oligodeoxynucleotid reduc hypernocicept downregul nav nav tnf cox pge upregul drg plantar skin inhibit tnf cox reduc hypernocicept tnf inhibit downregul nav nav antagon nf b p mitogen activ protein kinas mapk erk jnk reduc hypernocicept hyperexpress nav nav studi propos contribut tnf pnf bna v na v pathway pathophysiolog mous model incision pain | D048308;D016328 | T126;T116;T129 |
36,232,926 | last peripher central effect botulinum toxin type experiment muscl hypertonia rat recent anim experi suggest central transport botulinum toxin type bont might reduc abnorm muscl tone though unknown contribut domin peripher muscular effect observ clinic herein examin late bont antispast action persist due possibl central toxin action rat earli effect intramuscular im bont ukg revers tetanus toxin tent induc calf muscl spasm examin post tent later recoveri flaccid paralysi tent reinject day post bont lumbar intrathec bont neutral antiserum use discrimin transcytosi depend central toxin action ukg bont bont truncat synaptosom associ protein immunoreact examin muscl spinal cord day post bont dose ukg induc similar antispast action earli period day post bont repeat tent higher two dose prevent muscl spasm associ locomotor deficit central tran synapt activ contribut late antispast effect ukg bont ongo bont enzymat activ present inject muscl spinal cord observ suggest treatment durat sustain intermitt muscular hyperact might maintain higher dose combin peripher central bont action | D019274 | T116;T131;T121;T109;T129 |
36,232,925 | preval bacteri coinfect vibrio harveyi industri flow aquacultur system hainan provinc neglect high risk lethal causat agent hybrid grouper vibrio harveyi one serious bacteri pathogen aquat anim worldwid evid mount coinfect caus multipl pathogen common natur alter sever diseas marin anim howev bacteri coinfect involv v harveyi receiv littl attent maricultur studi result pathogen isol indic bacteri coinfect common overlook risk hybrid grouper epinephelus polyphekadion e fuscoguttatus rear industri flow pattern hainan provinc artifici infect hybrid grouper reveal coinfect v harveyi strain gdh serious lethal causat agent grouper isol pathogen result higher mortal infect strain gdh alon wherea mortal observ singl infect pathogen furthermor intestin liver spleen hybrid grouper target organ bacteri coinfect involv v harveyi base infect pattern found studi propos v harveyi may specif spatiotempor express pattern virul gene infect host taken togeth bacteri coinfect v harveyi neglect high risk lethal causat agent hybrid grouper industri flow aquacultur system hainan provinc | D001492;D060085;D005393;D014733;D014735 | T007;T047;T013 |
36,232,924 | tripartit efflux system affect flagellum stabil helicobact pylori helicobact pylori use cluster polar sheath flagella swim motil search homolog h pylori protein conserv helicobact speci possess flagellar sheath underrepres helicobact speci unsheath flagella identifi sever candid protein four identifi protein predict form part tripartit efflux system includ two transmembran domain abc transport hp hp periplasm membran fusion protein hp tolc like outer membran efflux protein hp delet hp hp hp homolog h pylori b result reduct motil number flagella per cell cryo electron tomographi studi intact motor hp hp hp mutant reveal mani cell contain potenti flagellum disassembl product consist decor l p ring report bacteria aberr motor lack specif compon includ cage like structur surround motor also observ hp mutant find suggest role h pylori hp hp tripartit efflux system flagellum stabil three independ variant hp hp mutant enhanc motil isol three motil variant frameshift mutat flil suggest role flil flagellum disassembl | D016480 | T007 |
36,232,923 | seqneo comprehens pipelin cancer neoantigen immunogen predict neoantigen deriv somat dna alter ideal cancer specif target recent year combin therapi pd pd l blocker neoantigen vaccin shown clinic efficaci origin pd pd l blocker non respond howev somat dna mutat result immunogen among cancer cell effici tool predict immunogen neoepitop still urgent need present seqneo pipelin provid one stop solut neoepitop featur predict use raw sequenc data neoantigen deriv differ type genom dna alter includ point mutat insert delet gene fusion support import convolut neural network cnn base model train predict immunogen neoepitop model show improv perform compar current avail tool immunogen predict use independ dataset anticip seqneo pipelin could becom use tool predict neoantigen immunogen cancer immunotherapi seqneo open sourc softwar academ free licens afl v freeli avail github | D019496;D009369 | T121;T191;T116;T129 |
36,232,922 | molecular pathogenesi colorect cancer impact oncogen target regul tumor suppress mir p recent determin rna sequenc base microrna mirna express signatur colorect cancer crc analysi signatur show express strand pre mir mir p guid strand mir p passeng strand signific reduc crc tissu transient transfect assay reveal express mir p block cancer cell malign transform eg cell prolifer migrat invas notabl express mir p mark block rac alpha serinethreonin protein kinas akt phosphoryl crc cell combin silico databas gene express analys mir p transfect cell reveal putat target regul mir p crc cell rna immunoprecipit analysi use argonaut ago antibodi reveal krt effici incorpor rna induc silenc complex aberr express keratin krt detect crc clinic specimen immunostain knockdown assay use small interf rna sirna target krt show reduc krt express suppress malign transform cancer cell migrat invas crc cell import inhibit krt express reduc akt phosphoryl crc cell moreov hexokinas hk express reduc cell transfect krt sirna mir p involv mirna passeng strand eg mir p crc cell new concept mirna studi tumor suppress mirna base approach help elucid molecular pathogenesi crc | D015179;D035683 | T191;T123;T114 |
36,232,921 | analysi influenc averag molecular weight content crosslink agent physicochem properti pvp base hydrogel develop innov dress hydrogel belong group polym three dimension crosslink structur crosslink densiti strong affect physicochem properti verifi impact averag molecular weight crosslink agent use photopolymer hydrogel content select properti materi first pvp base hydrogel modifi alo vera juic l ascorb acid prepar use uv radiat next surfac morpholog character via optic scan electron microscopi wherea chemic structur investig ft ir spectroscopi moreov verifi tendenc hydrogel degrad select physiolog liquid well tensil strength percentag elong swell capabl found crosslink agent hydrogel matrix higher tensil strength less elong hydrogel show highest stabil incub sbf hemoglobin solut sharp decreas ph distil water observ incub hydrogel probabl due releas alo vera juic hydrogel matric addit confirm decreas intens absorpt band deriv polysaccharid includ addit decreas swell ratio h import hydrogel demonstr swell properti proven higher content crosslink agent hydrogel lower swell abil | D000504;D020100 | T122;T002 |
36,232,920 | character molecular alter induc prolong exposur normal colon mucosa colon cancer cell low dose bisphenol colorect cancer common cancer poor prognosi male femal influenc bisphenol bpa wide use environment contamin colon cancer develop progress well identifi spite fact common mode exposur bpa ingest aim work elucid carcinogen effect bpa colon vitro analyz bpa effect human colon epitheli hcoepic colon cancer hct cell bpa exert cytotox effect augment fu cytotox cell line high dose show effect low dose therefor focus studi effect low dose nm exposur normal colon epitheli cell long period time two month consist environment exposur level pattern bpa increas cellular invas collagen abil anchorag independ cell growth measur coloni format soft agar could support oncogen gain insight mechan action perform transcriptom analysi use next generat sequenc reveal differenti express transcript bpa hct hcoepic transcript belong mani cancer relat pathway apoptosi cell prolifer signal transduct angiogenesi signific gene famh cxcl pitpna hmox dgkz nra vmp id confirm quantit rt pcr furthermor bpa induc phosphoryl protein kinas jnk gsk ampk akt ampk hsp catenin stat hck chk fak pras hcoepic well gsk p akt p kinas wnk hct major protein involv potenti carcinogen pathway taken togeth data suggest bpa play role colon carcinogenesi provid insight molecular mechan colon epitheli cell transform bpa increas exposur environment toxin bpa explain increas incid colorect cancer | D003110;D051176 | T191;T123;T116 |
36,232,919 | transcriptom analysi unravel potenti pathway gene involv pecan carya illinoinensi resist pestalotiopsi microspora fruit black spot fbs fungal diseas pecan carya illinoinensi wangenh k koch caus pathogen pestalotiopsi microspora serious diseas pose critic threat pecan yield qualiti howev detail pecan respons fbs infect transcript level remain elucid present studi use rna seq analyz differenti gene express three pecan cultivar vari resist fbs infect xinxuan x mahan wichita w categor low mild high suscept fbs respect nine rna seq librari construct compris total gb high qualiti base differenti express gene deg logfold chang p valu lt identifi vs x w vs w vs x respect kyoto encyclopedia gene genom kegg metabol pathway analys perform annot deg part specif pathway reveal total pathway mapk signal pathway plant pathogen interact plant hormon signal transduct high enrich transcriptom profil analysi reveal pathogen relat gene prgs includ gene encod wrki transcript factor potenti particip process defens pestalotiopsi microspora infect pecan correl wrki tfs prgs also perform reveal potenti interact network among diseas resistancepathogenesi relat gene wrki tfs express profil nine gene annot tifi wrki tf diseas resist protein relat gene perform use qrt pcr result correl rna seq data studi provid valuabl inform molecular basi pecan pestalotiopsi microspora interact mechan offer repertoir candid gene relat pecan fruit respons fbs infect | D031325 | T168;T002 |
36,232,918 | protect effect sesamin cyclophosphamid induc nephrotox modul oxid stress inflammatori cytokin apoptosi rat cyclophosphamid anticanc drug wide spectrum clinic use typic side effect multipl complic includ nephron toxic possibl molecular mechan nephroprotect action sesamin sm cyclophosphamid cp induc renal toxic investig rat understand oxid stress inflammatori cytokin studi rat arbitrarili group follow four group normal control group cnt cp induc toxic group treatment group two dose sesamin sm sm group sesamin sm alon singl dose cp mgkg bodi ip administ day experi treatment sm given oral seven day day group treat sm show signific protect effect cp induc renal damag rat treatment sm signific increas antioxid enzym gsh cat sod reduc malondialdehyd mda level thus sm signific overcam elev kidney function marker creatinin blood urea nitrogen uric acid attenu oxid stress sm also signific reduc elev cytokin il tnf caspas treat group histopatholog studi confirm protect effect sesamin sm cp induc nephrotox conclus current find support nephroprotect effect sesamin cp induc renal injuri | D000970;D051437 | T121;T047;T109 |
36,232,917 | studi synapt connect strength optogenet patch clamp electrophysiolog last two decad combin brain slice patch clamp electrophysiolog optogenet stimul proven power approach analyz architectur neural circuit experi depend synapt plastic network use combin method origin term channelrhodopsin assist circuit map cracm multitud measur synapt function taken current review discuss rational current applic field associ caveat specif review address assess presenc synapt connect term ionotrop versus metabotrop receptor signal term mono versus polysynapt connect acquir interpret measur synapt strength function like amparnmdar ampar rectif pair puls ratio ppr coeffici varianc input specif quantal size also address synapt modul g protein coupl receptor studi pharmacolog approach advanc technolog final elabor advanc use dual color optogenet concurr investig multipl synapt pathway overal review seek provid practic insight method use studi neural circuit synaps combin optogenet patch clamp electrophysiolog | D062308;D013569 | T030;T063 |
36,232,916 | effect age lifelong moder intens exercis train rat testicular function age associ testicular morpholog function alter under molecular mechan impact physic exercis poor understood studi examin effect age lifelong moder intens exercis rat testi matur adult week middl age week wistar unilev male rat maintain sedentari subject lifelong moder intens treadmil train protocol testi weight histolog mitochondri biogenesi function protein involv protein synthesi stress respons evalu result illustr age induc testicular atrophi associ alter stress respons mitochondri biogenesi function age associ increas testicular level heat shock protein beta hsp antioxid enzym age also associ decreas mrna abund nuclear respiratori factor nrf key transcript factor mitochondri biogenesi accompani decreas protein level oxid phosphoryl system oxpho complex subunit test older anim hand exercis protect age induc testicular atrophi led deleteri effect sperm morpholog exercis led even pronounc decreas nrf mrna level test age group associ decreas mrna abund mitochondri biogenesi marker decreas protein level oxpho complex subunit lifelong moder intens exercis train also associ increas testicular oxid stress marker possibl reduc translat togeth result indic exercis protect age induc testicular atrophi associ benefici chang mitochondria stress respons activ mechan protein synthesi inhibit | D000367;D010805;D013737 | T038;T023;T079 |
36,232,915 | character compar analysi chloroplast genom five uncaria speci endem china uncaria perenni vine rubiacea famili typic chines tradit medicin current uncertainti exist uncaria genus evolutionari relationship germplasm identif complet chloroplast genom four uncaria speci mention chines pharmacopoeia uncaria scanden easili confus counterfeit sequenc annot find demonstr whole chloroplast genom uncaria genus bp full length encod total gene contain protein code gene eight rrnas trnas region includ eleven high variabl loci ssrs use creat signific molecular marker uncaria genus phylogenet tree construct accord protein code gene whole chloroplast genom sequenc five uncaria speci use four method topolog two phylogenet tree show differ sequenc u rhynchophylla u scanden cluster one group u hirsuta u macrophylla cluster anoth group u sessilifructus cluster togeth two small clade new insight relationship reveal via phylogenet research five uncaria speci studi provid theoret basi identifi u rhynchophylla counterfeit well speci uncaria genus research provid initi chloroplast genom report uncaria contribut elucid chloroplast genom evolut uncaria china | D054628;D032070 | T002;T028 |
36,232,914 | trim maintain cell surviv respons oxid stress regul dna glycosylas stabil oxid dna base lesion dna repair base excis repair ber pathway consequ play vital role mainten genom integr suppress mutagenesi oxoguanin dna glycosylas ogg endonucleas iii like protein nth endonucleas viii like protein neil key enzym initi repair excis oxid base previous identifi e ubiquitin ligas tripartit motif trim control cellular respons oxid stress regul neil nth although potenti broader role ber unclear show trim central player determin respons differ form oxid stress use sirna mediat knockdown demonstr resist cell x ray radiat hydrogen peroxid generat consequ trim deplet revers suppress select dna glycosylas particular knockdown neil ogg enhanc sensit dna repair rate respons x ray wherea knockdown neil neil produc effect respons hydrogen peroxid studi therefor highlight import trim balanc cellular dna glycosylas level requir effici ber respons | D045647;D043224 | T126;T116 |
36,232,913 | acut endotoxemia induc respiratori intestin dysbiosi system inflammatori respons syndrom sir sever condit character system inflamm may lead multipl organ failur shock death sir common burn patient pancreat sepsi sir often accompani intestin dysbiosi howev mechan role detail microbiom alter earli phase acut sir complet understood current studi aim character dynam alter intestin respiratori microbiom two timepoint earli phase acut sir h lps link host respons mous model lps induc lethal sir acut sir effect microbiom larg intestin induc rapid dysbiosi small intestin resembl microbiom alter common observ sir patient later diseas progress dysbiosi respiratori microbiom observ associ mmp express lung although similar bacteria increas lung small intestin evid gut lung transloc observ gut dysbiosi common observ diseas involv inflamm gut howev whether inflammatori respons associ sir sepsi direct caus gut dysbiosi still unclear current studi provid evid lps induc sir direct caus dysbiosi small intestin respiratori microbiom | D019446;D000069196;D018805 | T007;T001;T047;T046 |
36,232,912 | inhibitori effect bacteri lysat extract pediococcus acidilactici differenti l pre adipocyt postbiot includ bacteri lysat consid altern probiot aim current studi investig effect bacteri lysat bls extract pediococcus acidilactici k k bl p acidilactici hw hw bl differenti l pre adipocyt k hw bls signific reduc accumul lipid droplet amount cellular glycerid l cell p lt howev anoth postbiot molecul peptidoglycan p acidilactici k p acidilactici hw moder inhibit accumul lipid droplet wherea heat kill p acidilactici effect inhibit lipid accumul mrna protein level transcript factor peroxisom prolifer activ receptor ccaatenhanc bind protein respons differenti l cell signific inhibit k bl hw bl p lt k hw bls decreas adipocyt relat molecul adipocyt fatti acid bind protein lipoprotein lipas mrna protein level furthermor k hw bls also downregul mrna express leptin resistin taken togeth result suggest p acidilactici bls mediat anti adipogen effect inhibit adipogen relat transcript factor target molecul | D017667;D002457;D000070016 | T007;T025;T026 |
36,232,911 | clinic valu pd pd lpd l pathway patient suffer endometriosi interact dendrit cell dcs cell mediat program cell death pd program cell death ligand pd l program cell death ligand pd l pathway import point regul immunolog toler autoimmun disturb quantiti matur activ dcs may involv implant growth endometri tissu outsid uterus endometriosi em howev littl known role immun checkpoint pathway em studi examin express pd lpd l myeloid dcs mdcs plasmacytoid dcs pdcs peripher blood pb periton fluid pf em patient n healthi subject n via flow cytometri concentr solubl pd l pd l plasma pf em patient control group determin use elisa demonstr elev percentag mdcs mdcs pdcs pd lor pd l express higher concentr solubl form pd l pd l pf plasma em patient conclud periton caviti environ pd pd lpd l axi may play import role modul immun respons develop andor progress em | D060890;D004715 | T191;T047;T116;T129 |
36,232,910 | role forkhead box pathogenesi therapi diabet mellitus type diabet diseas caus numer complic disrupt function entir bodi therefor new treatment diseas sought studi recent year shown forkhead box foxo protein may promis target diabet therapi foxo protein transcript factor involv numer physiolog process various patholog condit includ cardiovascular diseas diabet role includ regul cell cycl dna repair influenc apoptosi glucos metabol autophagi process age foxo import regul pancreat beta cell function affect pancreat beta cell condit insulin resist foxo also protect beta cell damag result oxid stress associ glucos lipid overload foxo shown affect number process involv develop diabet complic foxo regul pancreat cell function metabol stress also play import role regul wound heal therefor pharmacolog regul foxo protein promis approach develop treatment mani diseas includ diabet mellitus review describ role foxo protein pathogenesi diabet role modul foxo function therapi diseas | D003924;D050417 | T047;T025 |
36,232,909 | interplay gsk tau ser phosphoryl progress tau patholog tau hyperphosphoryl link direct format toxic neurofibrillari tangl nfts tauopathi howev prior nft format sequenc patholog event involv tau phosphoryl remain unclear effect glycogen synthas kinas gsk tau patholog examin independ step transcellular propag name tau intracellular aggreg releas cellular uptak seed activ find overexpress gsk induc phosphoryl nr tau led higher level tau oligomer sh syy neuroblastoma cell wild type nr determin sever orthogon assay interest presenc gsk also enhanc tau releas demonstr cell endocytos monomer tau protein pre phosphoryl gsk use extracellular vesicl ev assist tau neuron deliveri system show exosom gsk phosphoryl tau ad differenti sh syy cell induc effici tau transfer show much higher total tau level increas tau aggreg format compar wild type exosom tau role primari tau phosphoryl site target microtubul affin regul kinas mark ser test pseudo phosphoryl use site direct mutagenesi aspart sd sd tau overexpress signific enhanc tau releas intracellular tau accumul concurr increas patholog state tau determin immunodetect import phosphoryl induc tau accumul augment co transfect sd tau gsk suggest possibl interplay ser phosphoryl gsk activ tau patholog last found pre treatment cell amyloid tau phosphoryl accumul ser pre phosphoryl present suggest may primari mediat induc tau toxic find provid potenti therapeut target treat tau relat disord target specif phospho tau isoform elucid gsk mediat patholog seed mechan | D009447;D016875 | T191;T123;T116 |
36,232,908 | methodolog biolog factor influenc global dna methyl result measur line pyrosequenc assay colorect tissu liquid biopsi sampl long interspers nuclear element line bisulfit pyrosequenc wide use techniqu genom wide methyl analys aim investig effect experiment biolog factor result improv compar line bisulfit pyrosequenc perform colorect tissu n buffi coat n plasma sampl n healthi individu patient colorect tumor signific alter methyl observ investig line cpg posit non tumor tissu p formalin fix paraffin embed biopsi result lower methyl fresh frozen sampl p dna specimen long term storag show higher methyl level p blood collect tube preserv cfdna buffi coat methyl signific chang compar kedta tube p lower methyl detect older gt year vs younger femal patient p also adenomat tissu mthfr ct ac mutat vs wild type p comparison base find high recommend consid applic standard dna sampl case possibl clinic screen approach well experiment research studi | D000073888;D015179 | T191;T123;T114 |
36,232,907 | function mimicri eukaryot actin assembl pathogen effector protein actin cytoskeleton lie heart mani essenti cellular process hundr protein cell use control size shape actin cytoskelet network various pathogen util differ strategi hijack infect eukaryot host actin dynam benefit includ control upstream signal pathway lead actin assembl control eukaryot actin assembl factor encod toxin distort regular actin dynam encod effector direct interact assembl actin filament latter class effector uniqu quit often assembl actin straightforward manner use novel sequenc fold molecular mechan studi mechan promis provid major insight fundament determin actin assembl well deeper understand host pathogen interact general contribut therapeut develop effort target respect pathogen review discuss mechan highlight share uniqu featur actin assembl pathogen effector direct bind assembl actin focus eukaryot actin nucleat function mimic rickettsia sca formin mimic burkholderia bima enavasp mimic vibrio vopl tandem wh motif mimic | D000199;D056890 | T123;T116;T204 |
36,232,906 | antisens transcript plant systemat review updat cis nat sugarcan initi natur antisens transcript nat natrna asrna consid repressor howev function gene regul divers posit negat neutral correl cognat gene express note although first studi publish year ago still much investig regard antisens transcript plant systemat review scientif public avail web scienc databas conduct contextu studi antisens transcript address studi classifi consid three categori natur antisens artifici antisens use genet engin natur antisens genet engin relat public similar string use systemat search ncbi gene databas antisens sequenc found plant cite pubm antisens inform confirm valu lowest compar fungi bacteria mice final present updat cis nat identifi saccharum spp antisens transcript found differ experi show concord express discord correl cognat gene present variabl result depend experi | D031786 | T002 |
36,232,905 | hydrophob residu amino termin domain cx cx import gap junction channel ion permeat gate len gap junction gjs form cx cx import keep len transpar function studi cx cx gjs show v j gate singl channel conduct j gate polar andor channel open stabil could modifi charg residu amino termin nt domain role hydrophob residu nt gj properti clear crystal cryo em gj structur resolv nt domain structur either resolv show differ orient depend compon connexin possibl experiment condit make difficult understand structur basi nt v j gate j generat missens variant cx cx nt domain studi properti recombin express dual whole cell patch clamp experi connexin defici na cell nt variant cx li ne av qn cx il en va nq abl form function gjs similar coupl except cx ne show signific reduc coupl gjs cx ne av cx en nq show reduc coupl conduct v j gate variant gjs similar correspond wild type gjs except cx li j cx ne av cx en nq gjs reduc respect compar wild type j structur model cx li av predict steric clash residu tm residu might partial respons observ chang gj properti verifi import hydrophob interact generat variant cx st also show steric clash fail form function gj experiment result structur model indic hydrophob interact nt tm domain import v j gate j channel open stabil possibl gjs | D017629;D015640 | T043;T030 |
36,232,904 | engin mesopor silica base core shell nanoarchitectur synergist chemo photodynam therapi combinatori therapi garner enorm interest research effici devast malign tumor synergist effect explor combinatori approach multipl therapeut agent typic load deliveri vehicl control releas profil execut subsequ therapeut purpos herein report fabric core silica shell mesopor silica nanoparticl msns architectur deliv methylen blue mb cupric doxorubicin dox model drug synergist photodynam therapi pdt chemotherapi chemodynam therapi cdt mb photosensit initi load stabil silica core effici singlet oxygen generat light irradi toward pdt outsid shell imidazol silan modifi msns immobil chemotherapeut agent dox molecul metal copper cu ligand coordin interact achiev ph sensit releas trigger product intracellular hydrogen peroxid subsequ fenton like reaction assist cu catalyz free radic cdt design architectur systemat character use various physicochem character techniqu demonstr potent anti cancer efficaci skin melanoma togeth result demonstr msns base core shell nanoarchitectur great potenti effect strategi synergist ablat cancer chemo chemodynam photodynam therapi | D053758;D009369;D010778 | T191;T061;T073 |
36,232,903 | proteom profil stool sampl preterm neonat swathdia mass spectrometri predict necrot enterocol necrot enterocol nec life threaten condit prematur infant neonat intens care unit find indic predict nec develop symptom appear would provid time appli target intervent studi stool low birth weight vlbw infant collect daili context multi center prospect studi aim investig potenti fecal biomark nec predict use proteom technolog eight vlbw infant receiv stage nec diagnosi stool collect nec infant day diagnosi avail seven sampl match seven pair non nec control sampl process liquid chromatographi tandem mass spectrometri analysi use swathdia acquisit cross compat proteom softwar perform label free quantif roc curv princip compon analys use explor discrimin inform evalu candid protein marker seri protein show effici capac signatur predict seven nec infant least week advanc overal studi demonstr multiplex proteom signatur detect constitut promis approach earli detect nec develop prematur infant | D020345;D007232;D007235 | T047 |
36,232,902 | saffron extract attenu anxiogen effect improv cognit behavior adult zebrafish model traumat brain injuri traumat brain injuri tbi highest mortal rate worldwid yet effect treatment remain unavail tbi caus inflammatori respons endoplasm reticulum stress disrupt blood brain barrier neurodegener lead loss cognit memori motor skill saffron crocus sativus l known anti inflammatori neuroprotect effect make potenti candid tbi treatment zebrafish danio rerio share high degre genet homolog cell signal pathway mammal activ neuro regen function make excel model organ tbi therapeut drug identif object studi assess effect saffron administr tbi zebrafish model investig behavior outcom anxieti fear memori skill use seri behavior test saffron exhibit anxiolyt effect anxieti like behavior show prevent fear inhibit observ tbi improv learn enhanc memori perform result suggest saffron could novel therapeut enhanc neural repair regener network post tbi | D014151;D000070642;D027622;D018696 | T002;T037;T121;T169;T039 |
36,232,901 | genom wide investig express analysi nitraria sibirica pall cipk gene famili calcineurin b like interact protein kinas cipk protein famili play key role plant calcium ion mediat signal transduct pathway regul plant respons abiot stress nitraria sibirica pall n sibirica halophyt strong toler high salt environ yet abl deal salt stress molecular level still unknown due function describ plant speci cipk gene prime candid role salt stress signal n sibirica studi identifi analyz phylogenet makeup gene express n sibirica cipk gene famili total cipk identifi n sibirica genom cluster seven group base phylogeni promot nscipk gene contain multipl element involv hormon stress respons synteni analysi identifi total three pair synteni relationship nscipk gene gene show specif express pattern across differ tissu overal express cipk lowest cipk highest almost cipk gene tend respond salt drought cold stress differ sensit level studi provid general descript nscipk gene famili express great signific understand nscipk gene famili function | D018506;D010940 | T045;T116 |
36,232,900 | genom wide survey function verif nac transcript factor famili wild emmer wheat nac transcript factor tf famili one largest tf famili plant wide report rice maiz common wheat howev signific nac tf famili wild emmer wheat triticum turgidum ssp dicoccoid yet well understood studi genom wide investig nac gene conduct wild emmer genom nac famili member tdnac identifi result show gene contain namnac conserv domain predict locat nucleus phylogenet analysi show tdnac classifi seven clade like involv regul grain protein content starch synthesi respons biotic abiot stress express pattern analysi reveal tdnac high express differ wheat tissu grain root leav shoot found tdnac phylogenet close nac gene regul either grain protein starch accumul overexpress tdnac rice show increas grain starch concentr decreas grain fe zn mn content compar wild type plant protein interact analysi indic tdnac might interact granul bound starch synthas tdgbss regul grain starch accumul work provid comprehens understand nac tfs famili wild emmer wheat establish way futur function analysi genet improv increas grain starch content wheat | D000078522;D012275;D013214 | T116;T002;T126;T168;T129 |
36,232,899 | two import anticanc mechan natur synthet chalcon atp bind cassett subfamili g tubulin pharmacolog mechan decreas effect anticanc drug modul drug absorpt creat tubulin assembl polymer seri natur synthet chalcon report good anticanc activ half maxim inhibitori concentr lower modul observ case first mechan methoxi substitu aromat cycl acetophenon residu substitut phenyl nucleus heterocycl methoxi hydroxyl group posit impact inhibit tubulin compound bind colchicin bind site presenc methoxi group amino group heterocycl substitu increas activ | D000970;D002599;D047188 | T121;T109 |
36,232,898 | mutat interact analysi glycoprotein l thymidin kinas pseudorabi virus pseudorabi also call aujeszki diseas high infecti viral diseas caus pseudorabi virus prv suid herpesvirus although diseas control immun prv attenu vaccin emerg prv variant escap immun surveil vaccin pig result recent outbreak furthermor virus detect anim human indic cross transmiss prv howev mechan prv cross speci transmiss need studi studi compar amino acid sequenc glycoprotein gd gl thymidin kinas tk prv strain human prv hsd strain attenu strain bartha k follow predic spatial conform addit interact viral gd protein host nectin nectin hs also evalu via molecular dock result show amino acid sequenc homolog gd gl tk protein hsd jl cc respect moreov mutat amino acid sequenc gd gl tk protein hsd jl cc compar correspond refer sequenc bartha strain mutat gd gl tk might affect spatial conform protein domain may affect recognit antibodi antigen epitop moreov gd protein jl cc isol previous bind human nectin nectin hs suggest virus may high infecti pathogen human be | D011558;D011557;D013553 | T047;T005 |
36,232,897 | reactiv vertebr growth plate function vertebr bodi tether anim model flexibl spine tether relat novel fusionless surgic techniqu aim correct scoliosi base growth modul due pressur exert vertebr bodi epiphys growth plate correct occur two phase immedi intraop postop growth aim studi evalu reactiv vertebr growth plate function appli correct forc rat tail model use asymmetr compress distract caudal growth plate perform use modifi extern fixat apparatus radiolog histopatholog data analys three week correct activ structur increas across entir growth plate width plate thicken height hypertroph layer chondrocyt concav side doubl height height chondrocyt cartilag thick concav central side correct differ statist signific control group initi correct scoliosi grow spine relief pressur growth plate allow return physiolog activ growth cartilag restor deform vertebr bodi | D012600 | T047 |
36,232,896 | cerkl retin dystrophi gene regul mitochondri transport dynam hippocamp neuron mutat ceramid kinas like cerkl gene caus retin dystrophi character progress degener retin neuron eventu lead vision loss among function cerkl involv regul autophagi mitochondri dynam metabol retina howev cerkl near ubiquit express recent describ play protect role brain injuri show cerkl express hippocampus use mous hippocamp neuron explor impact either overexpress deplet cerkl mitochondri traffick dynam along axon describ pool cerkl local mitochondria hippocamp axon import deplet cerkl cerkl kdko mous model associ chang express fusionfiss molecular regul induc mitochondri fragment impair axon mitochondri traffick find highlight role cerkl retin dystrophi gene regul mitochondri health homeostasi central nervous system anatom structur retina | D009474;D017853;D012160;D058499 | T047;T023;T116;T126;T025 |
36,232,895 | inhibit complex respiratori chain complex iii attenu degranul cytokin secret human skin mast cell mechan mast cell mc degranul mc driven skin symptom well describ contrast data role mitochondri respir immun function human skin mcs lack oxygen consumpt rate ocr primari human skin mcs ige mediat activ absenc glucos examin use metabol flux analyz effect inhibit mitochondri complex rotenon iii myxothiazol degranul cytokin secret il il il il tnf gm csf explor hexosaminidas releas assay multiplex elisa ige mediat activ rapid increas mitochondri ocr extracellular acidif contribut non mitochondri oxygen consumpt remain unchang lower level myxothiazol rotenon reduc ocr mitochondri paramet extracellular acidif howev myxothiazol affect degranul cytokin secret contrast degranul secret il il tnf gm csf reduc rotenon wherea secret il il signific affect inhibitor affect cell viabil result highlight import role play mitochondri respir primari human skin mcs allow conclus hierarchi effector function drug target specif pathway mitochondria may provid futur option control mc driven skin symptom | D015550;D008407 | T043;T025 |
36,232,894 | tpo photoiniti replac golden mean camphorquinon tertiari amin dental composit test experiment composit contain differ concentr diphenyl trimethylbenzoyl phosphin oxid aim research compar biomechan properti experiment composit contain classic photoiniti system camphorquinon dimethylami ethyl methacryl diphenyl trimethylbenzoyl phosphin oxid tpo photoiniti produc light cure composit consist organ matrix bis gma wt tegdma wt silan silica filler wt composit contain wt tpo vicker hard microhard nanoindent test diametr tensil strength resist three point bend cie l b colorimetr analysi perform composit produc highest averag vicker hard valu obtain composit contain wt tpo hv diametr tensil strength remain regardless type amount photoiniti statist level except composit contain wt tpo dts mpa lowest record valu highest averag diametr tensil strength obtain composit contain wt tpo mpa highest modulus elast character composit contain wt tpo mpa composit contain wt tpo optim result term vicker hard diametr tensil strength flexur strength modulus elast moreov result better paramet character composit contain cqdmaema system term aesthet composit contain wt tpo less yellow color composit contain cqdmaema conclus object confirm test cie l b | D003188;D010087 | T122;T197 |
36,232,893 | prognost immunolog role stk across cancer friend foe although stk serin threonin kinas proven play import role cancer initi progress base seri cell anim experi system assess stk across human cancer avail first perform pan cancer analysi stk studi express level stk signific differ tumor normal tissu type cancer meanwhil prognosi analysi show distinct relationship exist stk express clinic prognosi cancer patient furthermor express stk relat infiltr immun cell nk cell memori cd cell mast cell cancer associ fibroblast cancer three immun associ signal pathway involv kegg analysi stk general stk show signific prognost valu differ cancer close associ cancer immun | D009369;D017346 | T191;T126;T116 |
36,232,892 | nontherm plasma effect fungi applic fungal respons futur perspect kingdom fungi rich speci live various environ exhibit differ lifestyl mani benefici indispens environ industri threaten plant anim human pathogen various strategi appli elimin fungal pathogen reli chemic nonchem antifung agent tool nontherm plasma ntp potenti tool inactiv pathogen food contamin fungi genet improv fungal strain use industri enzym metabolit produc ntp mode action due mani high reactiv speci interact biolog molecul interact ntp live cell believ synergist yet well understood review aim summar current ntp design applic challeng involv fungi well provid brief descript under mechan employ fungi interact ntp compon | D000935;D005658 | T121;T004;T195 |
36,232,891 | evalu free light chain flcs synthesi respons exposur sar cov aim studi assess synthesi kappa lambda free light chain flcs serum patient covid serum sampl collect patient covid healthi control vaccin non vaccin sar cov flcs igg total igg igg anti nucleocapsid n anti spike receptor bind domain rbd antibodi il measur accord manufactur instruct concentr anti n igg igg total igg il elev covid group comparison vaccin non vaccin control level anti rbd igg flc increas covid healthi vaccin patient compar non vaccin control flc concentr higher covid group non vaccin group ratio lower covid non vaccin group comparison vaccin control flc correl test paramet anti rbd igg anti n igg flc ratio igg total igg il except crp wherea flc correl examin paramet except igg elev level flcs covid healthi vaccin sar cov patient well correl free light chain specif anti sar cov antibodi il reflect hyperactiv immun system contact coronavirus furthermor seem serum level flcs might use predict marker covid find suggest free light chain involv sar cov infect howev understand exact mechan requir investig | D000086382;D000086402 | T047;T067;T005 |
36,232,890 | degrad motif stau defin novel famili protein involv inflamm cancer develop regul inflamm staufen stau rna bind protein whose express level critic cancer cell relat cell prolifer cell death stau protein level downregul mitosi due degrad e ubiquitin ligas anaphas promot complexcyclosom apcc paper map molecular determin involv stau degrad amino acid alanin scan shorten motif f pxpxxlxxxxl fpl motif mutat fpl motif prevent stau degrad apcc interest search databas reveal fpl motif share addit protein involv inflamm show one protein mapk inde degrad via fpl motif howev target apcc use proxim label stau identifi trim e ubiquitin ligas involv innat immun respons interferon product respons stau mapk degrad depend fpl motif result consist previous studi link stau cancer induc inflamm identifi novel degrad motif like coordin novel famili protein involv inflamm data avail via proteomexchang identifi pxd | D007249;D016601;D044767 | T126;T046;T123;T116 |
36,232,889 | studi tcpp hb scaffold physicochem properti biolog perform low oxygen concentr search new materi bone regen purpos still ongo therefor present seri newli construct composit base tricalcium phosphat tcp poli hydroxybutyr bacteria deriv biopolym p hb form scaffold differ pore size improv polym attach tcp surfac etch ceram sinter use citric acid appli expect pre treatment led increas surfac rough creation micropor facilit polym adhes way durabl compress strength ceram polym scaffold enhanc confirm p hb degrad hydroxybutyr acid broaden applic develop materi bone tissu engin compound potenti nourish surround tissu reduc osteoporosi moreov best knowledg one first studi impact tcpp hb scaffold mesenchym stem cell mscs cultur lower oxygen concentr assess decid use oxygen concentr cultur mimic condit would found damag bone live organ regener scaffold enabl cell migrat suffici flow cultur medium ensur high cell viabil furthermor composit etch tcp mscs adhes facilit hydrophil ceram protrus reduc hydrophob develop materi potenti candid bone tissu regener nevertheless confirm hypothesi vivo studi perform | D002130;D023822 | T121;T061;T197 |
36,232,888 | lc pda ms gc ms analysi scorzonera hispanica seed effect human breast cancer cell line scorzonera hispanica herbac perenni cultiv central southern europ studi aim qualit quantit evalu composit oil extract fraction sh sh obtain hispanica seed furthermor evalu biolog activ breast cancer cell line also perform gc ms analysi reveal primari compon seed oil sh fatti acid sitosterol evalu extract sh sh sh sh fraction sh sh sh composit presenc apigenin deriv p coumar caffeic acid report biolog assay methanol extract sh diethyl ether sh chloroform sh fraction exhibit cytotox toward cell highest activ observ fatti acid dimethoxycinnam rich sh ic gml mcf gml mda mb sh also observ induc apoptosi mcf cell sh sh sh attenu signal pathway affect express apoptosi autophagi inflamm relat protein sh non toxic toward either cancer normal cell line concentr mgml result suggest hispanica seed exhibit wide rang potenti use sourc oil bioactiv compound complementari therapi breast cancer | D001943;D031186 | T191;T002 |
36,232,887 | respiratori depress antibacteri mechan linalool pseudomona fragi base metabolom linalool show broad spectrum antibacteri effect studi elucid antibacteri mechan linalool pseudomona fragi p fragi date present studi aim uncov antimicrobi activ potenti mechan linalool p fragi determin key enzym activ metabolit combin high throughput method metabolom pathway analysi result linalool excel inhibitori activ p fragi mic mll addit presenc linalool signific alter intracellular metabol profil total differenti metabolit identifi regul regul highlight pathway includ beta alanin metabol pantothen acid coa metabol alanin aspart glutam metabol nicotin nicotinamid metabol overal linalool could caus metabol disord cell main metabol pathway involv energi metabol amino acid metabol nucleic acid metabol particular result intracellular atp content relat enzymat activ atpas sdh got also highlight energi limit amino acid disturb occur intracellular togeth find provid new insight mechan linalool inhibit p fragi theoret guidanc develop natur preserv | D000890;D009525;D009696;D044206;D012131 | T047;T046;T007;T121;T109;T127;T123;T114 |
36,232,886 | compar analysi environ respons altern splice infloresc cultiv wild tomato speci cultiv tomato solanum lycopersicum bred fruit product optim environ contrast harsh environ ancestr relat thrive process domest breed profound impact phenotyp plastic plant develop stress respons notabl altern splice precursor messag rna pre mrna one major factor contribut transcriptom complex respons development cue environment chang determin possibl associ event phenotyp plastic investig environ respons event infloresc cultiv tomato ancestr relat pimpinellifolium despit similar frequenc detect cultiv tomato varieti moneymak two pimpinellifolium access growth condit gene includ splice factor show differenti splice infloresc plant grown open field plastic greenhous moneymak varieti contrast two pimpinellifolium access la la gene show differenti splice respect moreov seven heat respons gene show opposit express pattern respons chang growth condit moneymak ancestr relat accord eight differenti express splice variant gene involv heat respons moneymak result reveal distinct featur event infloresc cultiv tomato ancestr relat show regul respons environment chang genotyp depend | D018551;D032322 | T168;T002 |
36,232,885 | enhanc rna erna human diseas enhanc rnas erna class non code rnas ncrnas transcrib enhanc region serv type critic regulatori element gene express increas evid demonstr aberr express erna broad detect various human diseas studi also reveal potenti clinic util erna diseas review summar recent studi regard patholog mechan erna well potenti util across human diseas includ cancer neurodegen disord cardiovascular diseas metabol diseas could help us understand erna engag process diseas obtain better insight erna diagnosi prognosi therapi studi review indic enorm therapeut potenc erna across human diseas | D009369;D012313 | T191;T114 |
36,232,884 | analysi long non code rna lncrna uca malat tc h express endometriosi endometriosi diseas complex etiolog hormon immunolog environment factor involv format recent year special attent paid genet mechan signific impact increas incid endometriosi studi aim analyz express four long non code rna lncrna gene uca malat tc h context risk develop endometriosi materi genet test express lncrna gene tissu slice embed paraffin block patient endometriosi n control group n gene express determin rt pcr techniqu express h gene endometriosi patient statist signific lower control group statist signific associ found h gene express relat revis american societi reproduct medicin classif endometriosi rasrm group patient endometriosi research suggest h express play import role pathogenesi endometriosi | D004715 | T191;T047 |
36,232,883 | crotalphin modul microglia mm phenotyp induc spinal analgesia mediat opioid cannabinoid system pain worldwid public health problem treatment still challeng sinc clinic avail drug complet revers chronic pain state induc undesir effect crotalphin amino acid synthet peptid induc potent long last analges effect acut chronic pain model peripher mediat endogen releas dynorphin desensit transient receptor potenti ankyrin trpa receptor howev effect crotalphin central nervous system cns signal pathway investig thus central effect crotalphin evalu partial sciatic nerv ligat psnl induc chronic neuropath pain model crotalphin gkg po induc analgesia th day surgeri last h administr effect prevent intrathec administr cb cb cannabinoid receptor antagonist besid crotalphin induc analgesia revers ctop bni naltrindol antagonist mu kappa delta opioid receptor respect also specif antibodi endorphin dynorphin met enkephalin likewis analges effect crotalphin block intrathec administr minocyclin inhibitor microgli activ prolifer addit crotalphin decreas psnl induc il releas spinal cord import vitro crotalphin inhibit lps induc cd express upregul cd express bv cell demonstr polar microgli cell toward phenotyp result demonstr crotalphin besid activ opioid cannabinoid analges system impair central neuroinflamm confirm neuromodulatori mechan involv crotalphin analges effect | D000698;D002186;D009437 | T047;T061;T121;T109;T184 |
36,232,882 | integr analysi identifi schizophrenia associ brain cell type gene express chang schizophrenia scz sever mental disord may result hallucin delus extrem disord think cell type brain contribut scz occurr still unclear leverag human dorsolater prefront cortex bulk rna seq data use rna seq deconvolut algorithm cibersortx generat scz brain singl cell rna seq data comprehens analysi understand scz associ brain cell type gene express chang first observ proport brain cell type scz differ normal sampl among cell type astrocyt pericyt pax cell found higher proport scz patient astrocyt scz control padj effect size pericyt scz control padj effect size pax scz control padj effect size litcar cell lamp cell exact opposit litcar scz control padj effect size lamp scz control padj effect size next investig gene express cell type function pathway scz observ chemic synapt transmiss dysregul two type gabaerg neuron pvalb lamp immun reaction involv gabaerg neuron sst non neuron cell type endotheli oligodendrocyt furthermor observ differenti express gene bulk rna seq display cell type specif abnorm express molecul scz final cell type scz relat transcriptom chang could consid belong modul sinc observ two major similar coordin transcriptom chang across cell type togeth result offer novel insight cellular heterogen molecular mechan under scz | D012559 | T048 |
36,232,881 | genom wide identif salt stress respons analysi bzip transcript factor famili sugar beet one largest transcript factor famili plant bzip transcript factor play import regulatori role differ biolog process especi process stress respons salt stress inhibit growth yield sugar beet howev bzip relat studi sugar beet beta vulgari l report studi aim identifi bzip transcript factor sugar beet analyz biolog function respons pattern salt stress use bioinformat bvbzip gene identifi genom sugar beet encod protein larg structur differ collinear analysi show three pair bvbzip gene fragment replic gene bvbzip gene group accord phylogenet tree topolog conserv structur result consist report arabidopsi salt stress express level bvbzip gene decreas eight gene regul go analysi show bvbzip gene main negat regul stress respons protein interact predict show bv bzip gene main involv light signal aba signal transduct also play certain role stress respons studi structur biolog function bvbzip gene analyz provid foundat data mechanist studi facilit effort toward molecular breed stress resili sugar beet | D017360;D027461 | T168;T002 |
36,232,880 | physiolog compar transcriptom analys high tiller mutant mtn reveal regulatori mechan tiller centipedegrass eremochloa ophiuroid munro hack tiller key factor determin reproduct yield centipedegrass import perenni warm season turfgrass howev regulatori mechan tiller perenni plant poor understood especi perenni turfgrass studi creat characteris cold plasma mutagenis centipedegrass mutant mtn tiller number phenotyp analysi show mtn mutant exhibit high tiller short internod long seed heavi seed weight compar transcriptom analysi mtn mutant wild type perform explor molecular mechan centipedegrass tiller result reveal plant hormon signal pathway well starch sucros metabol might play import role centipedegrass tiller hormon solubl sugar content measur exogen treatment result valid plant hormon sugar play import role centipedegrass tiller develop particular overexpress auxin transport atp bind cassett b eoabcb arabidopsi result branch singl nucleotid polymorph snps also identifi provid use resourc molecular marker assist breed centipedegrass accord physiolog characterist transcript express level relat gene regulatori mechan centipedegrass tiller systemat reveal research provid new breed resourc studi molecular mechan regul tiller perenni plant breed high tiller centipedegrass varieti | D017360;D058626 | T104;T002 |
36,232,879 | regul lipid metabol hepatopancrea shrimp litopenaeus vannamei upon light heavi infect enterocytozoon hepatopenaei compar proteom studi enterocytozoon hepatopenaei ehp pathogen hepatopancreat microsporidiosi hpm shrimp diseas shrimp litopenaeus vannamei exhibit slow growth syndrom caus sever econom loss herein label free quantit proteom employ analyz hepatopancrea l vannamei light ehpptp lt copi ng hpdna l group heavi ehpptp gt copi ng hpdna h group load ehp better understand pathogenesi hpm exact l group h group differenti express protein dep versus ehp free c group control main cluster lipid metabol amino acid metabol energi product process compar l group h group exhibit regul signific lipid metabol especi elong degrad fatti acid biosynthesi unsatur fatti acid metabol linolen acid sphingolipid glycerolipid well juvenil hormon jh degrad express pattern analysi show degre infect posit correl metabol chang ehp protein detect infect shrimp includ predict transport find suggest ehp infect induc consumpt storag lipid entir regul lipid metabol coupl energi product addit hormon metabol disord ultim respons stunt growth | D043143;D033561 | T023;T204 |
36,232,878 | discoveri vivo efficaci trace amin associ receptor taar agonist aminoethyl n dimethylphenyl piperidin carboxamid hydrochlorid ap treatment psychot disord start screen hit set analog synthes base aminoethyl piperidin core associ previous trace amin associ receptor taar modul literatur sever structur activ relationship general drawn observ data corrobor molecular model crystal structur taar four activ compound ec taar agonist activ rang nomin evalu vivo dopamin transport knockout dat ko rat model dopamin depend hyperlocomot use evalu compound efficaci vivo four compound one compound ap display statist signific dose depend reduct hyperlocomot dat ko rat compound ap repres viabl lead preclin character potenti novel treatment option disord associ increas dopaminerg function schizophrenia | D050483;D011618 | T123;T116;T048;T192 |
36,232,877 | cell free filtrat cff vector transmiss patholog tissu memori code hypothet narrat review cellular memori controversi concept repres abil cell write memor stress experi via epigenet oper progress cours chronic non communic diseas type diabet mellitus cancer arteriosclerosi like driven abnorm epigenet reprogram foster hypothesi cellular patholog memori accord cultur diabet cancer patient deriv cell recal behavior trait donor organ irrespect cultur time condit analyz data studi conduct group led cascad hypothesi aim valid hypothet exist transmiss cellular patholog memori diabet arteriosclerot peripher arteri diseas cancer experi base administr otherwis healthi anim cell free filtrat prepar human patholog tissu sampl repres diseas condit administr patholog tissu homogen consist induc faith recapitul diabet archetyp chang cutan arteriol nerv non thrombot arteriosclerot thicken collagen arteri encroach aberr angiogenesi vascular remodel pre malign malign epitheli mesenchym tumor differ organ evoc donor tissu histopatholog barrier interspeci transmiss hypothes homogen contain patholog tissu memori code repres solubl driver infiltr host anim cell ultim impos phenotyp signatur identif valid actor behind may pave way futur therapi | D003924;D058729 | T047 |
36,232,876 | activ roscncc signal pathway regul cytochrom p cypbq respons pinen toler dendroctonus armandi bark beetl main reli detoxif enzym resist host tree defens oleoresin terpen cytochrom p enzym cyp play import role detoxif plant allelochem pesticid insect one p gene dacypbq associ respons pinen dendroctonus armandi howev regulatori mechan p gene respons pinen still unknown studi spatiotempor express profil indic cypbq high express adult larval stage armandi predomin express fat bodi midgut malpighian tubul adult moreov express cypbq signific increas exposur pinen deplet decreas toler adult pinen addit pinen treatment induc express transcript factor cap n collar isoform c cncc bind factor muscl aponeurosi fibromatosi maf elev level hydrogen peroxid h increas activ antioxid enzym silenc cncc suppress cypbq express enhanc suscept beetl pinen similar applic reactiv oxygen speci ros scaveng n acetylcystein reduc product accumul h suppress express cncc maf cypbq led decreas toler adult pinen contrast ingest cncc agonist curcumin elev cypbq express enhanc pinen toler result demonstr armandi pinen induc cypbq via activ roscncc signal pathway | D003474;D010575 | T121;T109;T131;T130 |
36,232,875 | ph gradient liposom extract protein bound amitriptylin periton dialysi exploratori work poison signific caus injuri relat death worldwid dialysi usual ineffect remov toxin absorb drug protein bind high volum distribut work explor whether addit liposom periton dialys could extract protein bound amitriptylin liposom prepar use thin film hydrat method vitro experi ml albumin concentr nmoll amitriptylin proprietari dialysi cartridg dialys ml phosphat buffer salin without mg dioleoyl sn glycero phosphoglycerol dopg liposom vivo arm periton dialysi undertaken rat ph gradient liposom augment dialys intraven amitriptylin inject periton blood flow estim co extract total amitriptylin extract compar freeli dissolv non protein bound total amitriptylin perfus membran periton dwell mean liposom size dopg acid centr ph gradient liposom nm nm respect vitro experi amitriptylin extract liposom contain dialys control dialys nmoll vs nmoll vivo experi total amitriptylin dialys nmol mean total free amitriptylin perfus periton membran nmol mean total blood amitriptylin perfus periton membran nmol two six anim exclud due overestim periton blood flow exploratori work suggest addit liposom nanoparticl periton dialys extract protein bound amitriptylin blood | D000639;D010530 | T121;T061;T109 |
36,232,874 | isol prepar samwinol dracocephalum heterophyllum prevent induc neuroinflamm pc cell dracocephalum heterophyllum heterophyllum tradit chines tibetan medicin use treatment lymphiti hepat bronchiti howev select chemic compon current obtain heterophyllum limit pharmacolog applic studi obtain samwinol heterophyllum medium high pressur liquid chromatographi separ first time thereaft investig protect action samwinol amyloid beta protein fragment induc neurotox cultur rat pheochromocytoma pc cell explor under mechan action result indic samwinol could increas cell viabil inhibit product reactiv oxygen speci ros mitochondria deriv ros assess mtt assay giemsa stain flow cytometri assay western blot analysi found samwinol substanti inhibit phosphoryl erk promot express ho nrf data obtain molecular dock also consist conclus result show samwinol heterophyllum display signific anti neuroinflammatori antioxid activ vitro associ suppress erkakt phosphoryl activ nrfho signal pathway futur addit depth mechan studi carri provid evid potenti samwinol treatment alzheim diseas | D016229;D051267 | T123;T116 |
36,232,873 | exscalatecov innov high perform comput hpc strategi tackl pandem crisi special issu intend dissemin forum major result pursu exscalatecov project ec https www | D003205;D058873 | T057;T170;T067 |
36,232,872 | identif diosmin flavin adenin dinucleotid repurpos treatment monkeypox virus comput studi world health organ declar monkeypox global public health emerg juli diseas caus monkeypox virus mpxv first identifi denmark mpxv member poxvirida famili chordopoxvirina subfamili genus orthopoxvirus share high similar vaccinia virus virus use produc smallpox vaccin initi stage infect mpxv need attach human cell surfac glycosaminoglycan gag adhes molecul use e protein howev neither structur mpxv e protein specif cure mpxv exist studi aim search small molecul inhibit mpxv e protein use comput approach studi high qualiti three dimension structur mpxv e protein retriev homolog model use alphafold deep learn server subsequ molecular dock molecular dynam simul mds cumul durat microsecond reveal zinc diosmin zinc flavin adenin dinucleotid fad could potenti inhibitor e protein mmgbsa bind free energi kcalmol respect | D004145;D045908;D012900 | T121;T047;T109;T129 |
36,232,871 | comprehens review benefici effect catechin secondari mitochondri diseas mitochondria main site oxid phosphoryl synthesi adenosin triphosph cell known cellular power factori phrase secondari mitochondri diseas essenti refer abnorm mitochondri function primari mitochondri diseas ie process caus gene encod electron transport chain etc protein direct impact product machineri need etc mitochondri diseas caus adenosin triphosph atp synthesi disord increas oxygen free radic intracellular redox imbal also induc apoptosi eventu multi system damag lead neurodegen diseas catechin compound rich tea attract much attent due effect antioxid activ catechin especi acetyl catechin epicatechin gallat ecg epigallocatechin gallat egcg abl protect mitochondria reactiv oxygen speci review focus role catechin regul cell homeostasi catechin act free radic scaveng metal ion chelat protect mechan mitochondria protect effect catechin mitochondri deoxyribonucl acid dna review highlight catechin effect mitochondri function metabol network regul mitochondri function biogenesi improv insulin resist regul intracellular calcium homeostasi regul epigenet process final indirect benefici effect catechin mitochondri diseas also illustr warburg apoptosi effect possibl mechan shown graphic addit bioavail catechin peracetyl catechin free radic scaveng activ mitochondri activ abil high molecular weight polyphenol mitochondri activ factor also discuss | D002392;D028361;D019636 | T121;T047;T109 |
36,232,870 | biolog activ fac co phen aspirin fac co phen indomethacin origin counterpart ishikawa hec endometri cancer cell nonsteroid anti inflammatori drug nsaid inhibitor cyclooxygenas enzym cox found posit effect reduc risk develop gynecolog cancer howev long term administr nsaid carri risk various side effect includ digest circulatori system therefor constant need develop new nsaid deriv work investig rhenium nsaid compar effect endometri cancer cell origin nsaid demonstr high activ aspirin indomethacin deriv cytotox activ rhenium deriv ishikawa hec cancer cell line higher origin nsaid ic h incub ishikawa hec rhenium aspirin rhenium indomethacin respect time ic aspirin indomethacin ishikawa hec respect moreov deriv found inhibit prolifer cell line time state depend manner ishikawa cell prolifer strong inhibit rhenium aspirin rhenium indomethacin h incub p lt hec prolifer inhibit agent alreadi h incub p lt furthermor ros level mitochondria test cell generat presenc rhenium deriv higher origin nsaid associ rhenium indomethacin exclus signific effect p lt ishikawa hec cancer cell rhenium aspirin signific effect p lt mitochondri ros level ishikawa cell overal research reveal high potenti rhenium deriv aspirin indomethacin endometri cancer cell compar origin nsaid | D016889;D012211 | T191;T196 |
36,232,869 | effect neonicotinoid pesticid japanes water system review focus reproduct toxic neonicotinoid pesticid nps neurotox substanc high effect insecticid owe water solubl permeabl long last activ molecul structur similar nicotin act nicotin acetylcholin receptor agonist administr nps experiment anim report caus neuromuscular reproduct disord moreov recent report problem caus nps includ damag land dwell creatur mammal bird hydrobiolog ecosystem review summar recent report np concentr detect river system sever japanes region valu lower environment standard valu howev season variat observ furthermor report np induc testicular ovarian toxic examin reveal mechan injuri main driven oxid stress use nps declin worldwid except japan therefor continu monitor remain necessari | D007306;D010575;D011978;D014874 | T131;T116;T192 |
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