PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,868 | experiment comput studi interact dansyl base fluoresc schiff base ligand cu ion cuo nps studi interact cu ion cuo nanoparticl fluoresc schiff base ligand h l deriv condens formyl hydroxybenzo acid n aminobenzyl dimethylamino naphthalen sulfonamid dsa detail assign signific band electron infrar spectra h l dsa perform use dft method base crystal structur affin h l react cu ion solut k b l mol similar found cu ion present surfac cuo nps k b l mol fluoresc spectroscop measur suggest five bind site h l surfac cuo nps use xrf analysi indic polycrystallin sampl cuo h l nps contain cu molar ratio cuo h l atr ftir spectroscopi support dft calcul show hl phenol sulfonamid anion coordin superfici cu ion cuo nps azomethin sulphonamid phenol group solut h l ppb show sensit respons cuo nps limit detect lod ppb work rang detect cuo nps h l ppb ppm common metal ion water na k mg ca fe al speci interfer signific detect cuo nps | D053768;D053758 | T073 |
36,232,867 | pathophysiolog intersect diabet alzheim diseas diabet among preval diseas modern world strong link increas risk numer neurodegen disord although exact pathophysiolog mechan clear yet insulin resist serious patholog condit connect type diabet metabol syndrom obes recent insulin resist proven connect also cognit declin dementia includ preval form alzheim diseas relationship diabet alzheim diseas regard pathophysiolog signific propos present condit could term type diabet | D000544;D060825;D003924;D007333 | T047;T046;T048 |
36,232,866 | archaea microbiom dysregul gene pathway molecular target lung adenocarcinoma squamous cell carcinoma human microbiom vast collect microbi speci exist throughout human bodi regul various bodili function phenomena microbi speci exist human microbiom within archaea domain character extent common domain despit potenti uniqu metabol interact host cell research correl tumor presenc bacteri microbi speci develop progress lung cancer howev impact influenc archaea microbiom remain heavili unexplor within unit state lung cancer remain high fatal respons death everi year year surviv rate rough project attempt investig specif archaeal speci correl lung adenocarcinoma luad lung squamous cell carcinoma lusc incid patient stage death rate across individu vari age race gender smoke status potenti molecular target associ archaea microbiom archaeal speci abund assess across lung tissu sampl luad patient lusc patient healthi individu nine archaeal speci found signific alter abund cancer sampl compar normal counterpart common luad lusc subgroup sever speci taxonom class thermoprotei phylum euryarchaeota known contain metabol process distinct bacteri speci host microb metabol interact may respons observ correl speci abund cancer incid signific microb correl patient gene express reveal gene alter abund respect high low archaeal presenc gene cellular oncogen signal pathway analyz enrich across cancer normal sampl compar gene express luad adjac normal sampl gene set found signific enrich cancer lusc comparison set signific enrich cancer enrich normal microbi count across healthi cancer patient use develop machin learn base predict algorithm capabl distinguish lung cancer patient healthi normal accuraci | D000077192;D002289;D002294;D008175;D064307 | T191;T001;T032;T028 |
36,232,865 | compar metagenom metabolom reveal abnorm metabol activ associ gut microbiota alzheim diseas mice common symptom alzheim diseas ad cognit declin potenti pathogenesi remain unclear order understand mechan gut microbiota ad necessari clarifi relationship gut microbiota metabolit behavior test patholog examin metagenom metabolom appli analyz differ gut microbiota metabolom app swe ps e pap mice cognit declin age match control possibl correl result show pap mice health mice differ structur bacteri communiti gut abund divers bacteri communiti health mice higher pap mice metagenom analysi abund libanicoccus massiliensi paraprevotella clara lactobacillus amylovorus signific increas pap mice abund turicibact sanguini dubosiella newyorkensi prevotella ori great reduc furthermor pap mice possess peculiar metabol phenotyp stool serum hippocampus relat wt mice demonstr alter neurotransmitt metabol lipid metabol aromat amino acid metabol energi metabol vitamin digest absorpt bile metabol microbiota host metabol correl analysi suggest abnorm metabol stool serum hippocampus pap mice may modul gut microbiota especi sanguini newyorkensi p ori therefor abnorm metabol activ associ gut microbiota alzheim diseas mice result impli modifi host metabol target gut microbiota may novel viabl strategi prevent treatment ad futur | D000544;D000069196 | T007;T001;T047;T048 |
36,232,864 | medium composit impact staphylococcus aureus biofilm format suscept antibiot appli treatment bone infect biofilm associ infect bone life threaten diseas requir applic dedic antibiot order counteract tissu damag spread microorgan vitro analys biofilm format suscept antibiot frequent carri use method reflect condit site infect evalu influenc nutrient access staphylococcus aureus biofilm develop vitro cohes set analys three differ composit media perform next efficaci four antibiot use bone infect treatment includ gentamycin ciprofloxacin levofloxacin vancomycin staphylococc biofilm also assess result show signific reduct abil biofilm grow medium contain element occur serum also translat diversifi chang efficaci use antibiot compar set convent media appli differ indic need implement adequ vitro model close mimic infect site result present research may consid essenti step toward develop vitro analys aim accur indic suitabl antibiot appli biofilm relat infect bone | D010019;D013203 | T047 |
36,232,863 | express phosphoserin aminotransferas encod gene atpsat prompt starch accumul l turionifera nitrogen starvat demonstr phosphoryl pathway l serin ser biosynthesi ppsb import plant growth develop whether ppsb affect nitrogen metabol starch accumul fulli elucid studi took energi plant duckwe strain lemna turionifera research object use stabl genet transform system heterolog express arabidopsi atpsat gene encod phosphoserin aminotransferas second enzym ppsb result show nitrogen starvat transgen plant grew faster higher valu fvfm retr ii well fresh dri weight wild type promis accumul starch also found signific improv express atpsat transgen plant qrt pcr analysi result show express gene relat nitrogen assimil carbon metabol starch biosynthesi regul express starch degrad relat gene regul atpsat express propos increas starch accumul caus atpsat express may result elev photosynthet capac nitrogen util effici research shed new light mechan under abil ppsb coordin nitrogen carbon metabol provid feasibl way improv starch product engin ppsb crop | D017360;D029064 | T002 |
36,232,862 | practic signific biomark axial spondyloarthr updat diagnosi diseas activ prognosi axial spondyloarthr axspa chronic inflammatori diseas lead ankylosi secondari ossif inflammatori lesion progress disabl signific impact qualiti life also risk factor occurr comorbid especi cardiovascular diseas cvds mood disord osteoporosi malign earli diagnosi treatment need prevent decreas function declin improv patient prognosi respect axspa unmet need biomark help diagnos diseas defin diseas activ prognosi establish person treatment approach aim review summar avail inform regard promis biomark axspa classifi identifi six core categori biomark system marker inflamm ii molecul involv bone homeostasi iii hla b newer genet biomark iv antibodi base biomark v microbiom biomark vi miscellan biomark unfortun despit effort valid new biomark use clinic practic howev believ studi provid use data could aid better diseas manag | D000089183;D025241;D013167 | T047 |
36,232,861 | gene signatur associ tempor rhythm diagnost marker major depress disord role immun infiltr tempor rhythm tr involv pathophysiolog treatment respons major depress disord mdd howev systemat studi relationship tr relat gene trrgs mdd studi aim develop novel prognost gene signatur base trrgs mdd extract express inform gene express omnibus geo databas retriev trrgs genecard express gene trrdeg identifi differenti potenti biolog function analyz subsequ associ analysi receiv oper characterist roc curv adopt trrdeg upstream transcript factor tf mirna potenti drug target mdd predict final cibersort algorithm use estim proport immun cell subset identifi six trrdeg primarili involv malaria cardiac muscl contract calcium signal pathway four gene chga ccdc ackr fkbp auc gt consid trrdeg hub gene roc curv analysi outcom show higher ratio cell gamma delta cell monocyt neutrophil lower degre cd cell memori rest cd cell trrdeg four new trrdeg signatur excel diagnost perform relationship immun microenviron identifi | D003865;D035683 | T123;T048;T114 |
36,232,860 | hemorrhag cerebr insult secondari takotsubo syndrom find novel vitro model use human blood sampl intracrani hemorrhag result devast form cerebr damag frequent result also present cardiac dysfunct rang ecg chang takotsubo syndrom tts suggest intracrani bleed due subarachnoid hemorrhag sah disrupt neuro cardiac axi lead neurogen stress cardiomyopathi nsc differ degre follow notion sah secondari tts could direct link thus contribut poor outcom set test blood circul driver brain heart axi investig serum sampl tts patient present novel vitro model combin sah secondari tts mimic effect blood serum respect blood brain barrier bbb integr use vitro monolay establish murin model consist demonstr decreas monolay integr confirm reduc claudin occludin level rt qpcr western blot morpholog reorgan actin filament endotheli cell tight junction protein show time depend reduct find highlight faster promin disintegr bbb presenc tts support import bloodstream causal link intracerebr bleed cardiac dysfunct may repres potenti target futur therapeut invent sah tts | D013345;D054549 | T047;T046 |
36,232,859 | tumor intrins nuclear catenin associ immun ignor phenotyp poorer prognosi head neck squamous cell carcinoma activ wnt catenin signal associ non cell inflam tumor microenviron tme sever cancer aim work investig relationship catenin signal tme inflamm head neck squamous cell carcinoma hnsccs membran nuclear catenin express pd l express cd tumor infiltr lymphocyt til densiti joint evalu immunohistochemistri seri hpv negat hnsccs membran catenin level decreas carcinoma compar normal epithelium posit nuclear catenin detect tumor signific associ low cd til densiti cellsmm versus cellsmm nuclear catenin negat case p tendenc lower express pd l result associ noninflam tme ie type ii immunolog ignor multivari cox analysi demonstr low infiltr cd til hr ci p nuclear catenin express hr ci p independ associ poorer diseas specif surviv conclus tumor intrins nuclear catenin activ associ non inflam tme phenotyp poorer prognosi therebi suggest possibl implic immun exclus mechan subset hnscc patient | D060890;D006258 | T191;T116;T129 |
36,232,858 | nake decor nanoparticl contain h releas doxorubicin prepar character assess antitumor effici various resist tumor cell sever semisynthet low cardiotox doxorubicin doxo conjug extens describ consid risk cytotox loss resist tumor cell main present drug efflux capac doxorubicin phenyl thioxo h dithiol yl benzoat h doxo synthet test abil overcom drug resist good intracellular accumul paper present formul studi aim develop nake decor h doxo load lipid nanoparticl nps nps prepar cold dilut microemuls method decor hyaluron acid ha obtain activ target character physicochem properti drug entrap effici long term stabil vitro drug releas best formul test vitro human sensit mcf humanmous doxo resist mda mdb jc breast cancer cell human u os osteosarcoma cell doxo resist humanmous osteosarcoma cell u osdxkm ha decor ha cetyltrimethyl ammonium bromid electrostat interact nps surfac confirm zeta potenti element analysi tem nps mean diamet lower nm h doxo entrap effici stabl almost day ha decor nps accumul h doxo pgp express cell reduc cell viabil ha decor nps result best formul increas inter cellular h doxo deliveri kill resist cell therefor futur perspect taken account vivo experi tumor anim model | D001859;D053758;D012516 | T191;T073 |
36,232,857 | embryogen stem cell ident protoplast isol daucus carota recoveri regener abil protoplast cultur protoplast singl cell isol tissu organ consid suitabl system cell studi plant embryogen cell totipot stem cell regener abil decreas becom lost altogeth extens cultur period studi isol cultur ec deriv protoplast ec pts carrot compar non ec deriv protoplast nec pts respect totipot protoplast isol condit optim ec pts nec pts character cell size type type protoplast embed use algin layer tal method result ec pt tal nec pt tal cultur regener express ec specif gene serk wus bbm lec drn analyz confirm whether ec ident maintain protoplast isol protoplast isol effici ec pts fold higher nec pts protoplastsg fw ec pt group protoplast lt account total protoplast wherea nec pt group small protoplast account protoplast cultur number protoplast divid fold higher ec pts nec pts protoplastsg fw high number plant regener ec pt tal wherea plant induc nec pt tal five time plant regener ec pts ec regard express ec specif gene wus serk express increas fold lec bbm express increas fold isol protoplast compar ec prior protoplast isol control result reveal protoplast isol process affect embryogen cell ident rather increas plant regener rate confirm ec deriv protoplast cultur may effici system increas regener abil old ec cultur elimin old inactiv cell ec deriv protoplast may also repres effici singl cell system applic new breed technolog genom edit | D018552;D011523 | T025;T168;T002 |
36,232,856 | research progress bacteri membran vesicl antibiot resist result antibiot overus bacteri antibiot resist becom sever threat worldwid public health develop effect antimicrobi therapi altern antibiot strategi urgent requir role play bacteri membran vesicl bmvs antibiot resist becom current focus research bmvs nanoparticl deriv membran compon gram negat gram posit bacteria contain divers compon origin cell envelop cytoplasm antibiot stress stimul secret bmvs bmvs promot mediat antibiot resist multipl mechan bmvs investig conceptu new antibiot drug deliveri vehicl articl outlin research relat bmvs antibiot resist refer intent use bmvs combat antibiot resist | D000890;D001419 | T121;T007 |
36,232,855 | giardial arginin deiminas particip giardia host immunomodul structur depend fashion via toll like receptor beyond problem public health protist generat diseas repres understand varieti mechan use parasit interact human immun system biolog medic relev giardia lamblia earli diverg eukaryot microorgan show remark pathogen strategi evad immun system vertebr among various multifunct protein giardia arginin deiminas consid enzym play multipl regulatori role life cycl parasit one import role crosstalk parasit host molecular chat mediat human cell membran receptor call toll like receptor tlrs studi import structur giardial arginin deiminas gladi immunomodul human immun respons tlrs demonstr direct effect gladi human tlr signal predict mode interact tlrs two four use alphafold predict structur gladi molecular dock furthermor show immunomodulatori capac virul factor giardia depend mainten structur final also show influenc enzym exert specif respons infant like dendrit cell | D005872;D005873 | T047;T204 |
36,232,854 | chromon contain allylmorpholin influenc ion channel lipid membran via dipol potenti pack stress herein report chromon contain allylmorpholin affect ion channel form pore form antibiot model lipid membran correl abil influenc membran boundari potenti lipid pack stress gml allylmorpholin decreas boundari potenti bilay compos palmitoyloleoylphosphocholin popc mv time compound affect zeta potenti popc liposom reduc membran dipol potenti mv allylmorpholin induc drop dipol potenti produc enhanc conduct gramicidin channel chromon contain allylmorpholin also affect thermotrop behavior dipalmytoylphosphocholin dppc abolish pretransit lower melt cooper turn main phase transit peak multicompon profil compound abl decreas dppc melt temperatur c moreov deriv shown increas temperatur transit palmitoyloleoylphosphoethanolamin lamellar invert hexagon phase effect lipid phase transit attribut chang spontan curvatur stress alter lipid pack induc allylmorpholin believ potenti pore form abil amphotericin b gramicidin sever time | D006096;D008051 | T026;T116;T195 |
36,232,853 | genom wide identif aan zinc finger protein famili gene ipomoea batata two relat function analysi ibsap salin toler stress associ protein sap gene encod aan zinc finger domain contain protein play pivot role regul stress respons growth develop plant consid suitabl candid improv abiot stress toler plant howev sap gene famili sweetpotato ipomoea batata relat yet investig studi sap sweetpotato sap wild diploid relat ipomoea triloba ipomoea trifida identifi chromosom locat gene structur protein physiolog properti conserv domain phylogenet relationship sap analyz systemat bind motif analysi ibsap indic hormon stress respons cis act element distribut promot rt qpcr rna seq data reveal express pattern ibsap itbsap itfsap gene vari differ organ respond salin drought aba abscis acid treatment differ moreov found ibsap driven promot confer salin toler transgen arabidopsi result provid genom wide character sap gene sweetpotato two relat suggest ibsap involv salin stress respons research laid groundwork studi sap mediat stress respons mechan sweetpotato | D017360;D027741;D027723 | T168;T002 |
36,232,852 | call drug therapi treatment social behavior disord dementia systemat review evid state art grow evid support presenc social cognit deficit social behavior alter major minor neurocognit disord ncds even though abil identifi socio emot chang signific improv recent year still specif treatment avail thus explor evid drug therapi target social cognit alter ncds paper select accord prisma guidelin search pubm scopus databas paper report inform pharmacolog intervent treatment social cognit andor social behavior chang major andor minor ncds includ among articl enter paper select paper elig scope review trial test pharmacolog treatment socio emot alter ncds poor low medium qualiti attempt neuroprotect psychoact immunomodul drug made oxytocin drug specif target social brain test promis result frontotempor dementia benefici effect long term use yet evalu recommend current provid long way go identifi test effect target treat social cognit chang ncds ultim benefit patient caregiv | D057180;D010121 | T047;T116;T121;T048;T125 |
36,232,851 | previous unrecogn molecular landscap lynch syndrom mexican popul lynch syndrom ls main hereditari colorect cancer syndrom report regard clinic molecular characterist ls patient latin america particular true mexican popul inform avail present studi aim describ clinic molecular spectrum variant cohort patient diagnos ls mexico present retrospect analysi patient suspect ls whose main site cancer diagnosi colon follow endometrium next generat sequenc analysi extens multigen panel show variant one gene mismatch repair pathway mmr variant non mmr gene chek apc mutyh brca brca genet variant variant found mlh pathogen variant pvs mmr gene identifi total pvs non mmr gene molecular clinic character patient ls specif popul allow person follow option target treatment immun checkpoint inhibitor develop public health polici moreov character allow famili cascad test consequ prevent strategi | D003123 | T191;T047 |
36,232,850 | anti viral photodynam inactiv like bacteriophag mammalian virus model blood laboratori avail method appli plasma disinfect induc damag blood compon antimicrobi photodynam therapi apdt repres promis approach approv plasma platelet disinfect use non porphyrin photosensit pss methylen blue mb studi photodynam action three cation porphyrin tri py tetra py tetra py toward virus evalu white light irradi irradi mwcm result compar efficaci approv mb none pss caus hemolysi isoton condit use like phage model mammalian virus porphyrin effect mb photoinactiv like phage plasma moreov effici ps promot moder inactiv rate like phage whole blood nevertheless porphyrin mb consid promis safe pss photoinactiv virus blood plasma | D000890;D001435;D010778;D011166 | T061;T121;T109;T123;T005 |
36,232,849 | dynam transcript landscap grass carp ctenopharyngodon idella reveal key transcript featur involv fish develop high qualiti baselin transcriptom valuabl resourc development research well use refer studi gather sampl repres tissuesorgan import development time point within day fertil grass carp egg order systemat examin role lncrnas altern splice fish develop creat high qualiti grass carp baselin transcriptom complet percent combin strand specif rna sequenc singl molecul real time rna sequenc technolog obtain tempor express profil gene transcript develop tissu differenti famili short interspers element preferenti express earli stage zygot activ grass carp possibl regulatori compon discov analysi addit thorough analyz altern splice event discov retain intron ri altern splice event chang signific zygot activ tissu differenti zygot activ also reveal precis regulatori characterist under function ri event | D002347;D005393;D062085 | T047;T123;T013;T114 |
36,232,848 | growth hormon gh cross blood brain barrier bbb induc neuroprotect effect embryon chicken cerebellum hypox injuri sever motor sensori cognit behavior dysfunct associ neural lesion occur hypox injuri hi preterm infant growth hormon gh express upregul sever brain area expos hi condit suggest action local neurotroph factor known gh either exogen andor local express exert neuroprotect regen action cerebellar neuron respons hi howev still controversi whether gh cross blood brain barrier bbb effect exert direct mediat neurotroph factor found ovo microinject cy label chicken gh result wide distribut fluoresc within sever brain area chicken embryo choroid plexus cortex hypothalamus periventricular area hippocampus cerebellum normox hypox condit cerebellum cy gh gh receptor ghr co local granular purkinj layer deep cerebellar nuclei hypox condit suggest direct action histolog analysi show hypoxia provok signific modif size organ cerebellar layer howev gh administr restor width extern granular layer egl molecular layer ml improv purkinj granular neuron surviv addit gh treatment provok signific reduct apoptosi lipoperoxid decreas mrna express inflammatori mediat tnf il il ino upregul express sever neurotroph factor igf vegf bdnf interest also found upregul cerebellar gh ghr mrna express suggest exist endogen protect mechan respons hypoxia overal result demonstr chicken embryo expos hypoxia gh cross bbb reach cerebellum exert antiapoptot antioxid anti inflammatori neuroprotect neuroregen action | D018696 | T121;T169 |
36,232,847 | remd simul full length alpha synuclein togeth ligand reveal bind region effect amyloid convers alpha synuclein key protein involv develop progress parkinson diseas synucleinopathi intrins disord natur alpha synuclein hinder comput screen new drug candid treatment neurodegen diseas present work replica exchang molecular dynam simul full length alpha synuclein togeth low molecular ligand util predict bind site effect amyloid like convers protein approach enabl accur predict bind site three test compound fasudil phthalocyanin tetrasulfon spermin give good agreement data experi group lot inform bind protein conform ensembl enabl suggest putat effect ligand amyloid like convers alpha synuclein mechan anti pro amyloid activ test compound therefor approach look promis test new drug candid bind alpha synuclein intrins disord protein time estim effect protein behavior includ amyloid like aggreg | D000686;D064267 | T047;T123;T116 |
36,232,846 | lipidom determin giant panda respons serum fece follow exposur differ amount bamboo shoot consumpt first step toward lipidom atlas bamboo giant panda serum fece mean gc ms uhplc hrmsms lipid metabolit play essenti role host physiolog health growth perform serv major structur signal compon membran energi storag molecul steroid hormon bamboo wild giant panda exclus diet main determin giant panda lipidom direct sourc microbiota activ interest consumpt bamboo attract littl attent lipidom perspect current studi outlin lipidom atlas differ part bamboo gas chromatographi mass spectrometri gc ms abl obtain absolut quantif fatti acid pertain short chain fatti acid medium chain fatti acid long chain fatti acid long chain fatti acid liquid chromatographi coupl high resolut mass spectrometri uhplc hrmsms allow us obtain relat quantif anoth lipid among fatti acid quantifi absolut term eight show signific distinct concentr among differ bamboo part subsequ investig giant panda serum fecal lipidom adapt import annual chang diet repres consumpt high amount bamboo shoot typic spring weight gain season five fatti acid signific alter fece two serum respect due differ level bamboo shoot consumpt furthermor signific differ main bacteria strain observ fece two group genus level pertain streptococcus leuconostoc vagococcus correl giant panda fecal microbiom lipidom evalu pearson correl analysi find suggest balanc diet import overal lipidom function giant panda health could reach even remark case singl food base diet administ giant panda combin differ part bamboo specif lipidom profil | D001503 | T015 |
36,232,845 | probe mechan bind allosteri sar cov spike omicron variant complex host receptor reveal function role bind hotspot mediat epistat effect communic alloster pocket studi perform atom md simul rbd ace complex ba ba ba ba omicron subvari conduct systemat mutat scan rbd ace bind interfac analysi electrostat effect bind free energi comput omicron rbd ace complex comprehens examin electrostat interact quantifi drive forc bind provid new insight energet mechan under evolutionari differ omicron variant systemat mutat scan rbd residu determin protein stabil center bind energi hotpot omicron rbd ace complex employ ensembl base global network analysi propos communiti base topolog model omicron rbd interact character function role omicron mutat site mediat non addit epistat effect mutat find suggest non addit contribut bind affin may mediat r site greater omicron ba ba complex display strongest ace bind affin among omicron subvari network centric adapt model revers alloster communic unveil studi establish robust connect alloster network hotspot potenti alloster bind pocket use approach demonstr mediat center long rang interact could anchor experiment valid alloster bind pocket array complementari approach propos model comprehens multi facet comput studi reveal quantifi multipl function role key omicron mutat site r r act bind energi hotspot driver electrostat interact well mediat epistat effect long rang communic alloster pocket | D000086402 | T005 |
36,232,844 | selenium stimul exosom enhanc wound heal modul inflamm angiogenesi mesenchym stem cell msc deriv exosom emerg attract cell free tool tissu engin regen medicin current studi aim examin anti inflammatori pro angiogen wound repair effect exosom selenium stimul exosom check whether latter superior wound heal capac other cellular molecular network exosom paracrin signal extens studi perform mirna array explor key mediat exosom wound heal selenium known play critic role enhanc prolifer multi potenc anti inflammatori effect mscs selenium stimul exosom show signific effect inhibit inflamm improv pro angiogenesi human umbil vein endotheli cell cell growth migrat human dermal fibroblast wound regener enhanc selenium stimul exosom group selenium exosom group therebi promot wound heal vivo taken togeth selenium found augment therapeut effect adipos msc deriv exosom tissu regener conclud selenium may consid vital agent wound heal stem cell base cell free therapi | D055354;D035683;D012643 | T026;T121;T196;T123;T114 |
36,232,843 | oligonucleotid recogn topoisomeras inhibitor oti precis gene editor neurodegen diseas topoisomeras essenti enzym recogn modifi topolog dna allow dna replic transcript take place topoisomeras divid type topoisomeras cleav one dna strand modifi dna topolog type ii cleav dna strand topoisomeras normal rapid relig cleav dna topolog modifi topoisomeras recogn specif dna sequenc activ cleav posit supercoil dna ahead transcript bubbl replic fork negat supercoil precatenan behind thus allow unwind dna helix proceed transcript replic drug stabil dna cleavag complex topoisomeras produc cytotox dna damag kill fast divid cell wide use cancer chemotherapi oligonucleotid recogn topoisomeras inhibitor oti given drug stabil dna cleavag complex specif link either dna duplex recogn triplex form oligonucleotid tfo oti dna duplex recogn pyrrol imidazol polyamid pip oti ii convent watson crick base pair wc oti convert compound indiscrimin dna damag drug high specif target dna cleav oti herein propos simpl strategi enabl dna duplex strand invas wc oti give strand invad si oti make si oti similar guid rnas crisprca nucleas bacteri immun system howev import differ oti crisprca oti requir introduct foreign protein cell recent success oligonucleotid therapeut neurodegen diseas suggest oti develop high specif gene edit agent dna lesion caus neurodegen diseas | D019636;D009841 | T047;T114 |
36,232,842 | potenti rhizobia nodul anthylli vulneraria l ultramaf soil plant growth promot bacteria allevi nickel stress arabidopsi thaliana l rhizobia enter symbiosi legum also interact non legum promot plant growth paper explor effect nickel ni arabidopsi thaliana col inocul plant growth promot pgp rhizobia nodul ultramaf anthylli vulneraria isol pgp strain toler ni identifi rhizobium sp bradyrhizobium sp isol high differ pgp abil ni resist without ni stress plant inocul isol grew better higher photosynthet effici non inocul control nickel treatment increas ni concentr inocul plant plant growth leaf anatomi chloroplast ultrastructur effici photosynthesi antioxid defens system activ signific impair ni howev major effect diminish plant inocul effect pgp rhizobia real time pcr reveal increas express level gene involv auxin gibberellin biosynthesi inocul ni treat plant may improv shoot root growth inocul effect isol result also suggest posit correl ni stress paramet antioxid defens system activ also effect photosynthesi plant growth paramet show select rhizobia natur nodul anthylli ni rich ultramaf soil promot arabidopsi growth increas plant toler ni improv differ physiolog biochem mechan | D017360;D000070116;D012231 | T007;T002 |
36,232,841 | chang canin parvovirus variant year canin parvovirus cpv one import pathogen dog despit continu develop vaccin cpv cpv still circul canin popul cpv abc variant replac origin cpv virus seem exhibit acceler transmiss although cpv infect frequent report studi summar inform cpv variant current circul worldwid track evolut cpv download analyz vp sequenc ncbi databas found cpv c show tendenc replac cpv new domin variant asia south america north america africa addit cpv c preval region asia carri two special mutat vp ag qr becom domin mutat spillov alreadi occur conclus summari type global epidem variant provid new insight evolut cpv rais awar block spread virus spread asian deriv cpv c urgent need surveil | D004283;D010322;D017993 | T047;T005 |
36,232,840 | deep learn approach detect breast adenocarcinoma caus carcinogen mutat gene compos dna gene specif sequenc recombin replic within gene base end perman chang nucleotid collect dna call mutat mutat lead cancer breast adenocarcinoma start secretari cell breast adenocarcinoma common cancer occur women accord survey within unit state america breast adenocarcinoma patient regist month women recognit cancer earli stage save mani live propos framework develop earli detect breast adenocarcinoma use ensembl learn techniqu multipl deep learn algorithm specif long short term memori lstm gate recurr unit gru bi direct lstm type driver gene involv breast adenocarcinoma studi use dataset sampl includ men women taken cohort cancer detect institut dataset encompass total mutat occur gene gene sequenc differ algorithm appli featur extract three type test techniqu includ independ set test self consist test fold cross valid test appli valid test learn approach subsequ multipl deep learn approach lstm gru bi direct lstm algorithm appli sever evalu metric enumer valid result includ accuraci sensit specif mathew correl coeffici area curv train loss precis recal f score cohen kappa valu obtain respect | D000230;D001943;D000077321 | T191;T066 |
36,232,839 | enzymat construct darpin base target deliveri system use protein farnesyltransferas captur releas strategi protein base conjug extens util various biotechnolog therapeut applic order prepar homogen conjug site specif modif method effici purif strategi critic factor consid develop general facil conjug purif strategi therefor high desir appli captur releas strategi creat protein conjug base design ankyrin repeat protein darpin engin antigen bind protein promin affin select case darpin target epitheli cell adhes molecul epcam diagnost cell surfac marker mani type cancer employ darpin first genet modifi c termin cvia sequenc instal enzym recognit site label aldehyd function group employ protein farnesyltransferas use captur releas strategi conjug label darpin tamra fluorophor achiev either purifi protein direct crude e coli lysat use subsequ flow cytometri confoc imag analysi darpin mmae conjug also prepar yield construct manifest ic nm cell kill epcam posit mcf cell method describ broad applic enabl streamlin one step prepar protein base conjug | D017089;D000090922 | T044;T123;T116 |
36,232,838 | development transcriptom analysi red spot apollo butterfli parnassius bremeri parnassius bremeri p bremeri member genus snow apollo swallowtail famili papilionida high alpin butterfli live russia korea china endang wildlif class south korea global endang speci lack transcriptom genom resourc p bremeri signific hinder studi popul genet conserv detail inform development stage specif gene express pattern p bremeri great demand conserv howev molecular mechan under metamorph develop p bremeri still unknown present studi differenti express gene deg across metamorph development stage compar use high throughput transcriptom sequenc identifi total deg eight comparison go enrich analysi show rang deg respons cuticl develop melanin biosynthet pathway larval develop pathway analysi suggest signal pathway wnt signal pathway hedgehog signal pathway notch signal pathway regul development stage p bremeri furthermor sensori receptor also activ especi larval adult transit stage collect result studi provid preliminari foundat understand molecular mechan transcriptom research metamorph develop p bremeri | D002080 | T204 |
36,232,837 | rhosrf inhibitor modul mitochondri function ccg rho pathway inhibitor report inhibit rhosrf mediat transcript regul serum respons factor cofactor includ ternari complex factor myocardin relat transcript factor regul various cellular function studi observ ccg modul mitochondri function effect small molecul drug determin measur mitochondri function use xfe analyz oxygraph k ok high resolut respiromet ccg treatment signific reduc oxid phosphoryl dose depend manner howev ccg increas glycolyt rate also observ histon lysin underw hyperacetyl treatment drug immunolabel f actin mitotrack reveal alter actin cytoskeleton mitochondria taken togeth find highlight critic role ccg inhibit transcript srfp pgc result downregul mitochondri gene lead repress mitochondri oxid phosphoryl overal atp reduct studi provid better understand effect ccg mitochondria may use assess potenti clinic applic ccg deriv | D000199;D026362 | T123;T116 |
36,232,836 | spiropyranmerocyanin amphiphil various solvent joint experiment theoret approach photophys properti self assembl joint experiment theoret work focus molecular photophys properti spiropyran contain amphiphil molecul organ aqueous solut dissolv test organ solvent system demonstr posit photochrom ie upon uv stimulus colorless spiropyran form transform color merocyanin isom howev aqueous solut amphiphil possess negat photochrom orang red merocyanin form becom thermodynam stabl water uv vis stimuli lead partial complet photobleach solut explan phenomenon given basi densiti function theori calcul classic model includ thermodynam integr simul reveal stabil merocyanin water proceed energi ca kj mol helmholtz free energi hydrat merocyanin form kj mol lower compar behavior sp isom water explan differ lie molecular properti merocyanin ring open reaction molecul transform zwitterion form evidenc electrostat potenti plot around open form presenc three charg group peripheri flat conjug backbon stimul self assembl merocyanin molecul water end format elong associ stack like build block shown molecular dynam simul aqueous solut concentr critic micell concentr quantit evalu hydrophil switch spiropyranmerocyanin contain surfact may prompt search new system includ colloid polymer one aim remot tune morpholog could give new promis shape pattern need modern nanotechnolog | D008823;D014867 | T121;T109;T197 |
36,232,835 | toward mechanist model tau mediat patholog tauopathi learn cell base vitro assay tauopathi group neurodegen diseas character hyperphosphoryl deposit tau protein brain alzheim diseas relat tauopathi pattern tau deposit follow stereotyp progress anatom connect brain region increas evid suggest tau behav prion like manner seed spread patholog tau drive progress neurodegener although sever advanc made recent year exact cellular molecular mechan involv remain larg unknown sinc effect therapi tauopathi grow need reliabl experiment model would provid us better knowledg understand etiolog identifi novel molecular target review summar develop cellular model model tau patholog discuss differ applic contribut current understand prion like natur patholog tau | D000544;D011328;D024801 | T047;T116;T048;T005 |
36,232,834 | transcriptom analysi particul matter induc abnorm effect human sebocyt particul matter pm atmospher pollut aerodynam diamet lt caus serious human health problem includ skin damag sinc sebocyt involv regul skin homeostasi necessari studi effect pm sebocyt examin role pm via identif differenti express gene function enrich canon pathway analysi upstream regul analysi diseas biolog function analysi mrna sequenc xenobiot lipid metabol inflamm oxid stress cell barrier damag relat pathway enrich addit pm alter steroid hormon biosynthesi retinol metabol relat pathway consequ pm increas lipid synthesi lipid peroxid inflammatori cytokin express oxid stress alter lipid composit express factor affect cell barrier furthermor pm alter activ sterol regulatori element bind protein mitogen activ protein kinas transform growth factor beta smad forkhead box mediat pathway also suggest alter retinol estrogen metabol pm relat damag result valid use hairskin model thus result provid evid harm effect pm sebocyt well new target allevi skin damag caus | D004785;D052638 | T167;T131 |
36,232,833 | potenti role extracellular vesicl biomark parkinson diseas systemat review parkinson diseas pd slowli progress neurodegen disord character misfold aggreg synuclein syn lewi bodi degener dopaminerg neuron substantia nigra par compacta urg earli diagnosi biomark come fact clinic manifest pd estim appear substantia nigra deterior reduct dopamin level striatum nowaday extracellular vesicl ev play import role pathogenesi neuro degen diseas pd systemat review date august carri prefer report item systemat review meta analys aim analyz potenti role ev biomark pd total articl retriev elig review discuss role ev biochemistri cargo protein syn dj among other detect proteom analysi well mirna lncrnas potenti biomark use creat standard protocol earli pd diagnosi well evalu diseas sever progress | D000067128;D035683;D010300;D062085 | T026;T123;T047;T114 |
36,232,832 | translat multipl sclerosi anim model biomark discoveri clinic use multipl sclerosi ms chronic autoimmun diseas affect central nervous system character demyelin lesion axon damag ms complex diseas character import pathophysiolog heterogen affect clinic appear progress therapeut respons patient therefor strong unmet need defin specif biomark reflect differ featur diseas experiment autoimmun encephalomyel eae common use experiment model studi ms resembl patholog featur human ms mani aspect allow elucid pathogenesi pathway valid certain target ms therapi review discuss clinic relev ms molecular biomark divid five group base key patholog hallmark ms inflamm blood brain barrier disrupt myelin axon damag gliosi ultim repair mechan address feasibl translat anim model human diseas present overview sever molecular biomark categori compar respect deregul pattern conclud like diseas anim model eae model sometim fail mimic entir spectrum human diseas nonetheless recapitul diseas primari hallmark show eae model valuabl tool understand ms physiopatholog mechan identifi biomark fundament drug develop | D004681;D009103 | T050;T047 |
36,232,831 | atgstu atgstu moder respons arabidopsi thaliana turnip mosaic virus plant produc glutathion respons intercellular redox state glutathion activ particip reactiv oxygen speci ros depend signal pathway especi biotic stress condit glutathion transferas gsts induc cell defens respons plant high specif glutathion bind abil also particip signal function tau class gsts report induc respons stress condit although sever studi focus role tau class gsts plant pathogen interact knowledg contribut respons virus inocul still inadequ therefor studi respons atgstu atgstu knockout mutant mechan inocul turnip mosaic virus tumv examin system infect tumv dynam promot atgstu mutant wild type col plant suggest role gstu tumv resist howev atgstu mutant display virus limit downregul relat express tumv capsid protein accompani rare tumv particl vacuol ultrastructur analys inocul leav reveal lack virus cytoplasm inclus find indic atgstu mutant display resist like reaction tumv suggest gstu may suppress plant resist addit find confirm gstu gstu induc contribut suscept reaction tumv atgstu tumv interact howev upregul gstu gstu high correl virus limit resist like reaction atgstu tumv interact furthermor high dynam upregul gst glutathion reductas gr activ result signific induct day post inocul dpi total glutathion pool gsh gssg respons tumv accompani distribut activ glutathion plant cell contrari atgstu suscept tumv interact upregul gst gr activ dpi symptom develop report result induct total glutathion pool dpi observ indic gstu gstu import factor modul respons tumv arabidopsi thaliana moreov clear glutathion import compon regulatori network resist suscept respons thaliana tumv result help achiev better understand mechan regul arabidopsi tumv pathosystem | D017360;D017800 | T005;T002 |
36,232,830 | high immobil effici basic protein within heparin immobil calcium phosphat nanoparticl previous achiev one pot fabric heparin immobil calcium phosphat cap nanoparticl high dispers precipit process high supersatur reaction solut studi reveal heparin immobil cap nanoparticl greater co immobil capac basic protein acid protein process heparin act particl dispers agent also immobil agent basic protein remark approxim three fold improv immobil effici cytochrom c model basic protein within cap nanoparticl content cytochrom c immobil within nanoparticl increas increas cytochrom c concentr reaction solut age nanoparticl obtain nanoparticl dispers well water owe larg negat zeta potenti deriv heparin irrespect content cytochrom c similar result obtain also anoth basic protein lysozym acid protein albumin immobil effici albumin within nanoparticl decreas heparin find provid new insight co immobil strategi protein within heparin immobil cap nanoparticl use design fabric nanocarri protein deliveri applic | D053758;D010710 | T073;T197 |
36,232,829 | role fibroblast growth factor crosstalk hepat stellat cell uveal melanoma cell liver metastat nich hepat metastasi critic factor determin tumor associ mortal differ type cancer particular true uveal melanoma um almost exclus metastas liver hepat stellat cell hscs precursor tumor associ fibroblast support growth metastas howev under mechan wide unknown fibroblast growth factor fgf signal dysregul mani type cancer aim studi analyz pro tumorigen effect hscs um cell role fgfs crosstalk condit medium cm activ human hscs signific induc prolifer togeth enhanc erk jnk activ um cell silico databas analysi reveal almost mutat fgf receptor fgfr um howev high fgfr express found associ poor surviv um patient vitro pro tumorigen effect hsc cm um cell abrog pharmacolog inhibitor bgj fgfr express analysi reveal major paracrin fgfs express hscs um cell includ fgf furthermor immunofluoresc analysi indic hscs cellular sourc fgf hepat metastas um patient treatment recombin fgf signific enhanc prolifer um cell effect effici block fgfr inhibitor bgj studi indic fgf releas hscs promot tumorigen um cell thus suggest fgf promis therapeut target hepat metastasi | D008113;D014604 | T191 |
36,232,828 | prognost valu albumin globulin ratio non metastat metastat prostat cancer patient meta analysi systemat review aim meta analysi analyz data avail literatur regard possibl prognost valu albumin globulin ratio agr prostat cancer pc patient distinguish analysi term pc stage histolog aggress risk progress treatment literatur search process perform prostat cancer albumin globulin albumin globulin ratio follow prisma guidelin meta analysi pool event rate er estim group interest calcul use random effect model case distinguish low high agr group base optim cut valu defin roc analysi four clinic trial enclos sampl size rang case pool risk differ non organ confin pc high agr low agr case ci low rate heterogen lt p among studi test group differ p non metastat pc case pool risk differ biochem progress bcp high agr low agr case ci p test group differ p metastat pc case agr show independ signific p lt predict valu either term progress free surviv pfs odd ratio cancer specif surviv css meta analysi show homogen result support signific predict valu agr term stage grade biochem progress non metastat pc | D005916;D011471 | T191;T123;T116 |
36,232,827 | comprehens genom profil cgp inform person molecular residu diseas mrd detect exploratori analysi predat studi metastat colorect cancer mcrc patient undergo surgic resect major patient metastat colorect cancer mcrc experi recurr post curat intent surgeri addit adjuv chemotherapi shown provid limit surviv benefit appli patient therefor biomark assess molecular residu diseas mrd accur guid treatment select high desir high risk patient feasibl studi evalu prognost valu tissu comprehens genom profil cgp inform person circul tumor dna ctdna assay foundationon tracker foundat medicin inc cambridg usa correl mrd status clinic outcom ctdna analysi perform retrospect plasma sampl patient resect mcrc obtain mrd follow time point tissu cgp identifi potenti action alter patient mrd posit signific associ lower diseas free surviv dfs hr ci p lt overal surviv os hr ci p lt similar ctdna posit status follow time point correl mark reduct dfs hr ci p lt os hr ci p lt overal sensit specif follow time point respect result indic mrd detect use tissu cgp inform ctdna assay prognost surviv outcom patient resect mcrc concurr mrd detect identif action alter potenti guid periop clinic decis make | D000074141;D003110;D015179;D012004 | T191;T114 |
36,232,826 | improv trimethylangelicin analog cystic fibrosi design synthesi preliminari screen small librari new angelicin deriv design synthes aim bypass side effect trimethylangelicin tma promis agent treatment cystic fibrosi prevent photoreact dna hinder substitu insert andor posit unlik parent tma none new deriv exhibit signific cytotox mutagen effect among synthes compound phenylderiv phenylderiv exert promis fdel cftr rescu abil compound preliminari vivo pharmacokinet pk studi carri evidenc favor pk profil per se incorpor lipid formul therefor select compound good candid futur extens investig evalu develop novel cftr corrector base angelicin structur | D003550;D011564 | T121;T047;T109 |
36,232,825 | nitric oxid act inhibitor postharvest senesc horticultur product horticultur product display fast senesc harvest ambient temperatur result decreas qualiti shorter shelf life gaseous signal molecul nitric oxid import physiolog effect plant specif area regul postharvest senesc tremend progress made review summar synthesi effect allevi postharvest senesc mechan allevi senesc interact signal molecul ethylen eth abscis acid aba melatonin mt hydrogen sulfid h hydrogen gas h hydrogen peroxid h calcium ion ca aim review provid theoret refer applic postharvest senesc horticultur product | D006862;D008550 | T131;T121;T109;T130;T197;T125 |
36,232,824 | therapeut advanc immunotherapi hematolog malign follow success immunotherapi chimer antigen receptor transgen cell car therapi bispecif cell engag therapi immun checkpoint inhibitor treatment hematolog malign studi underway improv efficaci immunotherapi reduc complic associ use combin immun checkpoint inhibitor convent chemotherapi studi novel therapeut strategi bispecif tandem dual car bispecif killer cell engag trispecif killer cell engag dual affin retarget therapi also underway studi discoveri novel immunotherapeut target molecul use immunotherapi diseas initi thought less promis treat treatment method acut myeloid leukemia cell hematolog tumor becom realiti thus come era new transplant chemotherapi free treatment strategi imper scientist clinician understand molecular immun hematolog malign review focus remark develop immunotherapi could chang prognosi hematolog diseas also review molecular mechan develop process clinic efficaci problem new agent | D019337;D000076962 | T191;T192;T116;T129 |
36,232,823 | axen cultur caenorhabd elegan alter lysosomalproteasom balanc increas neuropeptid express axen cultur c elegan show mani characterist trait worm subject dietari restrict slow develop reduc fertil increas stress resist henc term axen dietari restrict adr often appli adr dramat extend worm lifespan compar dr regimen bacteri dilut howev under molecular mechan still remain unclear primari goal studi comprehens investig transcript alter occur worm subject adr estim molecular physiolog chang may underli adr induc longev one enrich cluster regul gene adr condit link lysosom activ proteasom gene signific regul regul gene specif involv amino acid metabol like respons high peptid level found axen cultur medium gene relat integr function muscl extracellular matrix also regul consist regul gene involv dna replic repair may reflect reduc fertil phenotyp adr worm neuropeptid gene found larg regul suggest possibl involv neuroendocrin signal adr induc longev conclus axen cultur worm seem reli increas amino acid catabol reloc protein breakdown cytosol lysosom invest dna mainten rather retain muscl integr extracellular matrix chang may coordin peptiderg signal | D029742;D009479 | T123;T116 |
36,232,822 | direct submicrofib hydrogel composit scaffold support neuron differenti enabl neurit align cell cultur aim tissu regener benefit scaffold physiolog relev elast moduli optim trigger cell attach prolifer promot differenti guidanc tissu matur complex scaffold design guid cue mimic anisotrop natur neural tissu spinal cord brain recal abil human neural progenitor cell differenti align work introduc cost effici gelatin base submicron pattern hydrogel fiber composit tune stiff abl support cell attach differenti align neuron deriv human progenitor cell enzymat crosslink gelatin base hydrogel generat stiff kpa onto poli caprolacton pcl align cue electrospun fiber preferenti align fiber hydrogel composit modulus kpa show strongest cell attach highest cell prolifer render ideal differenti support differenti neuron align bundl neurit along align pcl filament uniqu cell type fiber hydrogel composit novel scaffold reli robust inexpens technolog suitabl neural tissu engin direct neuron align requir spinal cord | D020100;D016501 | T026;T122 |
36,232,821 | potenti role myokin adipos tissu metabol exercis cold exposur exercis cold exposur two stimuli suggest sole effect modul adipos tissu metabol improv metabol health obes popul two primari organ involv energi metabol exercis andor cold exposur skelet muscl adipos tissu adipos tissu divid main two type white adipos tissu wat primarili store energi brown adipos tissu bat known primari sourc thermogenesi exercis stimul releas myokin allow crosstalk skelet muscl adipos tissu partial mediat benefici effect exercis cold exposur anoth trigger regul myokin secret thus increas adipos tissu metabol especi via activ bat therefor generat hypothesi exercis conjunct cold exposur might optim regimen regul myokin profil gain benefici health effect howev date human experiment data regard differ exercis frequenc type time intens cold exposur temperatur time frequenc pattern scarc review summar current human clinic trial investig regul myokin induc exercis combin cold exposur elabor role myokin mediat adipos tissu metabol | D002001;D022722 | T024;T040 |
36,232,820 | tumor inform approach improv ctdna detect rate resect pancreat cancer pancreat cancer one cancer poor prognosi urgent need identifi novel biomark improv clinic outcom circul tumor dna ctdna liquid biopsi arisen promis biomark cancer detect surveil howev known ctdna detect rate resect pancreat cancer low compar type cancer studi collect pair tumor plasma sampl pancreat cancer patient plasma sampl collect patient treatment nave status patient neoadjuv therapi nat genom profil tumor dna plasma sampl conduct use target next generat sequenc ngs somat mutat detect tumor ctdna detect treatment nave nat group respect without refer inform tumor profil tumor inform approach tia ctdna detect rate improv treatment nave nat group respect detect rate signific improv p among treatment nave group compar nat group case detect plasma ctdna concord correspond tumor show signific shorter recurr free surviv rfs p demonstr tia improv ctdna detect rate pancreat cancer ctdna could potenti prognost biomark recurr risk predict | D000074141;D010190 | T191;T114 |
36,232,819 | nitrat nitrit nitric oxid pathway mechan hypoxia anoxia toler plant oxygen crucial substrat numer biochem process plant depriv critic factor affect plant growth may lead death last long time howev various biotic abiot factor caus depriv lead hypoxia anoxia plant tissu surviv hypoxia andor anoxia plant deploy various mechan ferment path reactiv oxygen speci ros reactiv nitrogen speci rns antioxid enzym aerenchyma adventiti root format nitrat nitrit nitric oxid shown numer benefici role modul mechan therefor review highlight role reduct pathway format lessen deleteri effect oxid damag increas adapt capac plant hypoxia anoxia meanwhil overproduct reduct pathway hypoxia anoxia lead cellular dysfunct cell death thus scaveng inhibit equal import plant surviv plant also report produc potent greenhous gas nitrous oxid n suppli resembl bacteri denitrif role hypoxia anoxia toler discuss point reduct n along phytoglobin cycl could import scaveng mechan would reduc nitro oxid stress thus enhanc plant surviv limit condit henc understand molecular mechan involv reduc toxic would provid insight role plant physiolog also address uncertainti seen global n budget | D000074382;D009573 | T121;T123;T197 |
36,232,818 | mechan kale brassica oleracea var acephala toler individu combin stress drought elev temperatur rise temperatur pronounc drought signific affect biodivers worldwid reduc yield qualiti brassica crop elucid mechan toler kale access b oleracea var acephala evalu individu osmot elev temperatur stress combin stress osmot temperatur use root growth biomass prolin content reliabl marker access evalu stress respons four repres select investig photosynthet perform biochem marker sugar content special metabolit transcript level transcript factor nac hsf dreb express heat shock protein hsp hsp sensit moder sensit toler toler access toler stress condit character higher basal content prolin total sugar glucosinol higher transcript nac dreb stress condit character signific decreas biomass root growth photosynthesi perform fructan content especi osmot combin stress signific increas hsf transcript hsp accumul temperatur stress signific decreas nac transcript stress toler access appli stress show least chang analyz paramet compar access | D001937 | T168;T002 |
36,232,817 | transcriptom proteom menstrual blood deriv mesenchym stem cell tell us endometriosi given import menstrual blood pathogenesi endometriosi multifunct role menstrual mesenchym stem cell mensc regen medicin issu gain promin scientif communiti moreov recent review highlight robust integr assess omic data endometriosi knowledg studi appli multi omic approach endometriosi mensc case control studi univers affili hospit mensc transcriptom proteom data obtain rna seq uhplc msms detect among differenti express protein gene emphas atf id id fosb snai nra egr lamc zfp gene mta tymp cola cola nid protein alreadi report endometriosi function enrich analysi reveal integr modul signal pathway epitheli mesenchym transit pik signal via akt mtorc proteom mtorc signal tgf beta signal tnfa signal via nfkb il stat signal respons hypoxia via hifa target transcriptom find highlight primari chang endometriosi mensc suggest chronic inflammatori endometri microenviron modul cell provid opportun endometriosi etiopathogenesi moreov identifi challeng futur research leverag knowledg regen precis medicin endometriosi | D004715;D059630 | T191;T047;T025 |
36,232,815 | radiofrequ ablat indetermin thyroid nodul first north american compar analysi thyroid nodul classifi benign malign indetermin latter make nodul radiofrequ ablat rfa becom attract promis therapi treatment benign thyroid nodul howev studi investig safeti efficaci rfa manag indetermin thyroid nodul studi patient thyroid nodul diagnos benign bethesda ii indetermin bethesda iiiiv preoper cytopatholog analysi includ patient benign indetermin cohort similar thyroid nodul volum reduct rate respect p two group similar nodular regrowth rate benign nodul indetermin nodul p total three case transient dysphonia report rfa indetermin thyroid nodul compar benign thyroid nodul paramet interest includ volum reduct rate best knowledg work first north american analysi compar benign indetermin thyroid nodul suggest rfa promis modal manag indetermin thyroid nodul | D017115;D000078703;D016606 | T191;T061 |
36,232,814 | experiment clinic evid suggest treatment betacellulin allevi th type cytokin mediat impair skin barrier function betacellulin btc peptid ligand belong epiderm growth factor famili member implic skin morphogenesi homeostasi repair angiogenesi howev role btc regul skin barrier remain unknown examin role btc skin barrier function analyz atop dermat ad transcriptom data gene express omnibus geo dataset perform btc immunohistochemistri use human skin tissu evalu effect btc primari human keratinocyt real time pcr western blot assay transepiderm electr resist ter function paramet monitor tight junction barrier found gene express btc downregul skin lesion patient ad downregul express recov follow biolog treatment consist btc protein level downregul lesion skin ad patient compar normal skin healthi particip suggest btc level skin might biomark diagnosi therapi ad furthermor human keratinocyt btc knockdown reduc level skin deriv antimicrobi peptid skin barrier relat gene wherea btc addit enhanc level import human skin equival btc restor increas tight junction permeabl induc th cytokin il il treatment addit specif inhibitor epiderm growth factor receptor egfr protein kinas c pkc abolish btc mediat improv skin barrier relat protein keratinocyt monolay collect find suggest treatment btc might improv th type cytokin mediat impair skin barrier function egfrpkc axi btc might novel potenti biomark therapeut target treatment skin condit character overproduct th cytokin dysfunct skin barrier ad | D016207;D003876 | T047;T116;T129 |
36,232,813 | gut brain axi insight hippocamp neurogenesi brain tumor develop mous model experiment coliti induc dextran sodium sulfat chronic inflammatori bowel disord ibd idiopath diseas associ alter intestin permeabl turn caus exagger immun respons enter antigen genet suscept host rise psych cognit disord anxieti depress observ ibd patient report investig model chemic induc experiment coliti oral administr sodium dextran sulfat dss cbl mice investig vivo crosstalk intestin brain evalu consequ intestin inflamm neuroinflamm hippocamp adult neurogenesi use differ dss administr strategi abl induc acut chronic coliti simul clinic characterist observ ibd patient bodi weight loss colon shorten alter intestin mucosa fecal metabol chang amino acid lipid thiamin relat pathway observ coliti activ inflammatori process colon confirm macrophag infiltr increas express proinflammatori cytokin oxid stress marker il ino interest hippocampus acut dss treat mice report upregul inflammatori relat gene il il tgf smad togeth microgliosi chronic dss treatment also result neuroinflamm hippocampus indic astrocyt activ evalu stage specif neurogenesi marker reveal deficit dentat gyrus acut chronic dss treatment indic defect adult hippocamp neurogenesi final base possibl causal relationship gut relat inflamm brain cancer investig impact dss induc coliti oncogenesi use ptch cbl mice well establish medulloblastoma mb mous model find differ mb develop untreat dss treat mice conclus experiment model intestin inflamm associ acut chronic coliti mark influenc brain homeostasi impair hippocamp neurogenesi mb oncogenesi | D001932;D003092;D015212 | T191;T047 |
36,232,812 | chemonast stalk gland carnivor rainbow plant bybli gigantea lindl byblidacea lamial carnivor rainbow plant bybli byblidacea lamial possess sticki flypap trap captur retent digest prey main small insect trap system base multitud millimet size glandular trichom also term stalk gland produc adhes glue drop centuri trap system bybli consid passiv mean plant movement involv recent remark discoveri made stalk gland bybli inde capabl react chemic protein stimuli slow movement respons prompt us investig phenomenon seri experi stimul kinemat actuat function morpholog stalk gland cultiv bybli gigantea plant measur stalk gland length densiti trap leav similar data literatur motion reaction could trigger chemic stimuli corrobor prior studi stalk gland sensit reaction time ie time stimul onset motion movement durat temperatur depend hint toward tight physiolog control involv process stalk gland movement consist sequenc twist kink motion render possibl compon stalk cell wall furthermor anatom mechan predetermin orient cellulos microfibril cell wall success water displac process stalk cell basal cell actuat movement kinemat could observ stalk gland dri air submers satur salt solut stimul dri stalk gland well hyperton medium capabl regain initi shape rehydr water howev glue product could observ afterward long time overlook chemonast movement stalk gland may help bybli retain digest prey howev research need shed light ecolog characterist rainbow plant trap system | D000086523;D000068378 | T002 |
36,232,811 | nanomateri review halloysit nanotub properti applic biolog field use synthet materi attent toward environment hazard toxic impos develop green composit natur origin clay one candid approach halloysit natur clay miner member kaolin group characterist tubular morpholog usual name halloysit nanotub hnts differ surfac chemistri halloysit allow select modif extern surfac inner lumen supramolecular coval interact interest aspect hnts relat possibl introduc differ speci releas slowli compar pristin compound due uniqu hollow morpholog larg caviti hnts employ optim natur nanocarri review discuss structur properti applic hnts biolog field highlight high biocompat analys opportun use new hnt hybrid drug carrier deliveri system | D007616;D043942 | T121;T073;T197 |
36,232,810 | role rna methyl thyroid cancer cell line n methyladenosin abund intern modif rna eukaryot cell recent year gain increas attent good amount data support involv modif tumorigenesi tumor progress metastat dissemin howev role rna modif thyroid cancer still remain poor investig studi relat rna methyl profil compar normal thyroid cell line differ thyroid cancer cell line approach possibl identifi differ pattern modif differ thyroid cancer model furthermor silenc mettl main player rna methyl machineri possibl evalu impact modif gene express anaplast thyroid cancer model experiment approach allow us identifi ddi gene specif control modif anaplast thyroid cancer cell line altogeth data proof concept rna methyl wide occur thyroid cancer cell model open way forward search new molecular pattern diagnost discrimin benign malign lesion | D065646;D013964 | T191 |
36,232,809 | evodiamin rutaecarpin potenti anticanc compound combin comput studi evodiamin evo rutaecarpin rut main activ compound tradit chines medicin herb evodia amp nbsp rutaecarpa fulli optim molecular geometri evo rut blyp g p level densiti function theori natur popul analysi npa charg frontier molecular orbit molecular electrostat potenti chemic reactiv descriptor evo rut also investig furthermor molecular dock molecular dynam simul analysi bind free energi evo rut carri anticanc target topoisomeras top clarifi anticanc mechan dock result indic could inhibit top intercal cleav dna bind site form top dna ligand ternari complex suggest may potenti top inhibitor molecular dynam md simul evalu bind stabil top dna ligand ternari complex calcul bind free energi show bind abil evo top stronger rut result elucid structur activ relationship antitumor mechan evo rut molecular level suggest evo rut may potenti compound develop new anticanc drug | D000970;D032086 | T121;T109;T002 |
36,232,808 | acut system white blood cell chang follow degen cervic myelopathi dcm mous model degen cervic myelopathi dcm caus age relat degener cervic spine caus chronic spinal cord compress inflamm aim studi assess whether natur progress dcm accompani hematolog chang white blood cell composit chang use diagnosi complement establish imag approach develop treatment strategi sinc peripher immun affect progress dcm gradual compress spinal cord induc cbl mice c level composit circul white blood cell analyz longitudin four time point induct dcm use flow cytometri week serum cytokin level measur use luminex x map assay neurolog impair mous model also assess use ladder walk test catwalk step function p lt overground locomot p lt impair dcm group import circul monocyt cell affect primarili week follow dcm cell two fold lower dcm group p lt wherea monocyt four fold increas p lt dcm compar sham group data suggest chang white blood cell popul modest uniqu spinal cord patholog preced develop neurobehavior symptom | D013117;D013118 | T047 |
36,232,807 | associ common variant ola gene preclin atherosclerosi reactiv oxygen speci impair blood vessel lead initi atherosclerosi migrat prolifer vascular smooth muscl cell neovascular endotheli cell vasa vasorum essenti atherosclerosi develop obg like atpas ola negat regul cellular respons oxid stress bind breast cancer suscept gene brca protect vascular endotheli smooth muscl cell reactiv oxygen speci howev known whether ola genet correl atherosclerosi conduct two independ popul base case control studi explor effect variant ola gene preclin atherosclerosi total subject thicker normal carotid intima media thick cimt respect enrol among screen snps rs rs rs rs rs ola show signific associ cimt snp rs utr variant correl differenti express ola immun cell five genet marker form singl close link block h attgt h gcctc top two preval locus haplotyp h h genotyp negat h h genotyp posit correl thicker cimt five identifi snps ola gene show signific correl cimt furthermor found ola requir migrat prolifer human aortic endotheli smooth muscl cell regul vascular tube format human aortic endotheli cell therefor genet variant ola gene may serv marker risk predict atherosclerot diseas | D050197;D059168 | T047;T046;T201 |
36,232,806 | sar cov spatiotempor genom molecular analysi first wave covid pandem maca brazilian capit oil sar cov virus infect led million death covid pandem hundr worker sever brazilian citi well countri arriv daili maca work oil suppli chain make citi putat hotspot introduct new viral lineag studi perform genom survey sar cov sampl maca first outbreak covid combin clinic data molecular integr analysi first phylogenom analys show high occurr viral introduct event establish local transmiss maca includ ingress spread b lineag municip june august second sar cov mutat identifi patient distinct level covid sever third molecular interact mutat spike protein three b local sampl human ace show higher interact wild type spike protein ancestr virus altogeth result elucid sar cov genom profil strateg brazilian citi explor function aspect sar cov character emerg viral mutat associ clinic data potenti target drug develop sar cov | D000086382;D000086402 | T047;T067;T005 |
36,232,805 | therapeut potenti mesenchym stem cell secret factor delay corneal wound heal nitrogen mustard ocular surfac exposur nitrogen mustard nm lead sever ocular toxic includ separ epitheli stromal layer loss endotheli cell cell death sever loss tissu function definit treatment mustard gas induc ocular surfac disord current avail research conduct investig therapeut potenti mesenchym stem cell condit media msc cm nm induc corneal wound nm ad differ type corneal cell ocular surfac porcin ocular surfac mice follow msc cm treatment nm signific induc apoptot cell death cellular ros reactiv oxygen speci reduc cell viabil metabol gene express mitochondri function turn delay wound heal applic msc cm post nm exposur partial restor mitochondri function decreas intracellular ros generat promot cell surviv msc cm therapi enhanc wound heal process msc cm inhibit nm induc apoptot cell death murin porcin corneal tissu applic msc cm follow chemic insult led signific improv preserv corneal structur wound heal vitro ex vivo vivo result suggest msc cm potenti provid target therapi treatment chemic eye injuri includ mustard gas keratopathi mgk present signific loss vision alongsid numer corneal patholog | D065306;D059630;D009151 | T037;T131;T109;T025;T033 |
36,232,804 | character two mous chd heterozyg loss function model show dysgenesi corpus callosum previous unreport featur charg syndrom charg syndrom rare congenit disord frequent caus mutat chromodomain helicas dna bind protein chd develop systemat character two genet mous model ident heterozyg loss function mutat chd gene engin inbr outbr genet background found model show consist phenotyp core clinic manifest seen charg syndrom phenotyp inbr chd model sever sometim reduc penetr includ dysgenesi corpus callosum hypoplasia hippocampus abnorm retrospleni granular cortex ventriculomegali hyperact growth delay impair grip strength repetit behavior interest also identifi previous unreport featur includ reduc level basal insulin reduc blood lipid suggest phenotyp variat report individu diagnos charg syndrom like due genet background modifi final studi provid valuabl resourc make possibl mous biologist interest chd make inform choic mous model use studi phenotyp interest investig depth under cellular molecular mechan | D058747 | T047 |
36,232,803 | analysi host bacteria protein interact reveal conserv domain motif mediat fundament infect pathway adhes colon host cell pathogen bacteria depend protein protein interact ppis interact interest pharmacolog point view sinc new molecul inhibit host pathogen ppis would act new antimicrobi interact discov use high throughput method may display high fals posit rate absenc curat databas make avail data unreli address issu comprehens filter process develop obtain reliabl list domain motif particip ppis bacteria human cell structur point view analysi reveal human protein involv interact rich alpha helix disord region poorer beta structur disord region human protein harbor short sequenc motif specif recogn certain domain pathogen protein relev domain domain interact valid alphafold show proper analysi host pathogen ppi databas reveal structur conserv pattern domain motif interact contrari difficult valid sinc unstructur region involv alphafold could make good predict moreov interact also like accommod post translat modif especi phosphoryl potenti occur host protein henc common structur pattern involv host pathogen ppis retriev avail databas inform requir proper infer full interactom resolv issu combin new predict tool like alphafold new class antimicrobi could discov detail understand interact | D054884;D011506 | T116;T123;T040 |
36,232,802 | character new defensin antimicrobi peptid express bed bug respons bacteri ingest inject common bed bug cimex lectularius carri transmit pathogen vertebr host feed compon innat immun system bed bug antimicrobi peptid amp elimin pathogen determin molecular characterist structur properti phylogenet related two new defensin cl defensin xp cl defensin xp two new defensin isoform cl defensina xp cl defensinb xp complet amino acid sequenc cl defensin cl defensin cl defensina cl defensinb strong conserv minor differ signal pro peptid region use combin compar transcriptom real time quantit pcr evalu express defensin midgut rest bodi insect inject bacteria ingest blood contain gram posit gr bacterium bacillus subtili gram negat gr bacterium escherichia coli demonstr first time sex specif immun mode specif upregul bed bug defensin respons inject ingest gr gr bacteria understand compon defensin bed bug innat immun system respons pathogen may help unravel bed bug transmit pathogen vertebr | D001511 | T204 |
36,232,801 | swim train affect muscl lactat metabol nicotinamid adenin dinucleotid concentr activ nadh shuttl enzym mous model amyotroph later sclerosi studi aim verifi whether swim train improv lactat metabol nad nadh level well modifi activ glycolyt nadh shuttl enzym monocarboxyl transport mcts skelet muscl amyotroph later sclerosi al mice al mice sodga n per group analyz onset al first diseas symptom train untrain last stage diseas train untrain compar wild type wt group mice blood lactat skelet muscl concentr lactat nad nadh mct mct protein level well lactat dehydrogenas ldh malat dehydrogenas mdh activ skelet muscl determin fluorometr western blot liquid chromatographi ms spectrometri spectrometr method untrain termin al group decreas blood lactat level p lt increas skelet muscl lactat level p lt compar wt group mice amount nicotinamid adenin dinucleotid al group also signific reduc well ldh activ level mct swim train increas lactat level blood p lt vs al termin untrain addit cytosol mdh activ cmdhldh ratio signific higher train vs untrain mice p lt data indic signific dysfunct lactat metabol al mice associ reduct muscl anaerob metabol nadh transport enzym well swim induc compens energi demand al mice | D000690;D009243 | T121;T047;T123;T114 |
36,232,800 | novel insight pyoverdin biosynthesi biotechnolog applic pyoverdin pvds class siderophor produc most member genus pseudomona primari function accumul mobil transport iron necessari cell metabol moreov pvds also play crucial role microb surviv mediat biofilm format virul review reorgan inform produc recent year regard pvds biosynthesi pathogen mechan sinc pvds extrem valuabl compound addit summar therapeut applic deriv pvds use focus role therapeut target assess current biotechnolog applic differ sector evalu state art technolog relat use synthet biolog tool pathway engin final review recent method techniqu capabl identifi molecul complex matric drug discoveri purpos | D009842;D017262 | T109;T123;T116 |
36,232,799 | mirna promis therapeut target cancer microrna small non code rnas regul sever gene post transcript complementar pair sinc discoveri report involv varieti biolog function patholog includ cancer cancer act tumor suppressor oncomir depend cell type studi shown mirna base therapi either inhibit oncomir induc tumor suppressor effect cancer treatment review focuss role mirna cancer therapeut approach mirna effect deliv system also summar patent clinic trial progress mirna therapi | D035683;D009369 | T191;T123;T114 |
36,232,798 | genotyp phenotyp differ cadasil asian perspect cerebr autosom domin arteriopathi subcort infarct leukoencephalopathi cadasil hereditari cerebr small vessel diseas caus mutat notch gene classic pathogen mechan associ cystein gain loss recent studi suggest cystein spare mutat might potenti role pathogen comparison cadasil patient western countri sever differ asian patient preval locus notch mutat exon particular exon vs exon age symptom onset preval cerebr microble hemorrhag stroke clinic symptom sever white matter hyperintens typic involv anterior tempor pole magnet reson imag ethnic founder effect contribut differ clinic notch spectrum differ cohort function investig divers race need clarifi unknown novel variant notch mutat review may broaden spectrum notch variant asian perspect draw attent hidden pathogen role notch variant | D046589 | T047 |
36,232,797 | impact novel pagr like transcript regul cereulid toxin synthesi emet bacillus cereus emet type foodborn diseas caus bacillus cereus produc small peptid toxin cereulid genet locus encod ces nonribosom peptid synthetas cesnrp multienzym machineri locat kb megaplasmid design pcer share backbon bacillus anthraci toxin plasmid pxo although ces gene plasmid born chromosom encod pleiotrop transcript factor codi abrb key player control ces transcript sinc protein repress cereulid synthesi earlier growth phase factor must involv strict control ces express embed bacteri life cycl silico genom analysi reveal pcer carri putat arsrsmtb famili transcript factor show high homolog pagr b anthraci pagr play crucial role regul protect antigen gene paga form part anthrax toxin use gene inactiv approach combin electrophoret mobil shift assay bacteri two hybrid system dissect role pagr homologu pagrbc regul cereulid synthesi result highlight plasmid encod transcript regul pagrbc play import role complex multilay process cereulid synthesi | D001408;D047630 | T007;T116 |
36,232,796 | milk exosom microrna postnat promot cell prolifer potenti induc cell de differenti adult life pancreat cell expans function matur birth wean period driven epigenet program primarili trigger growth factor hormon nutrient provid human milk shown recent exosom deriv various origin interact cell review elucid potenti role milk deriv exosom mex microrna mir pancreat cell program postnat period lactat well continu cow milk exposur adult human bovin mex mechanist evid suggest mex mir stimul mtorcc myc depend postnat cell prolifer glycolysi attenu cell differenti mitochondri function insulin synthesi secret mex mir content negat affect matern obes gestat diabet psycholog stress caesarean deliveri complet absent infant formula wean relat disappear mex mir may critic event switch cell prolifer tgf ampk mediat cell differenti wherea continu exposur adult human bovin mex mir via intak pasteur cow milk may revers cell differenti promot cell de differenti wherea mex mir signal support postnat cell prolifer diabet prevent persist bovin mex exposur lactat period may de differenti cell back postnat phenotyp diabet induct | D055354;D035683 | T026;T123;T114 |
36,232,795 | complementari set autoantibodi induc sar cov adenovirus bacteri antigen cross react human blood protein antigen covid coagulopathi covid patient often develop coagulopathi includ microclot thrombot stroke thrombocytopenia autoantibodi present blood relat protein includ cardiolipin cl serum albumin sa platelet factor pf beta glycoprotein gpi phosphodiesteras pde coagul factor factor ii ix x von willebrand factor vwf differ combin autoantibodi associ differ coagulopathi previous research reveal similar protein blood clot function sar cov protein adenovirus bacteri protein associ moder sever covid infect studi investig whether polyclon antibodi main goat rabbit virus bacteria recogn human blood relat protein antibodi sar cov adenovirus recogn vwf pde pf sar cov antibodi also recogn addit antigen bacteri antibodi test group streptococci gas staphylococci escherichia coli e coli klebsiella pneumonia clostridia mycobacterium tuberculosi cross react cl pf gas antibodi also bound f factor viii factor ix vwf e coli antibodi pde cross reactiv interact involv antibodi antigen bind constant smaller nm sinc covid coagulopathi patient display autoantibodi vwf pde pf along cl combin viral bacteri infect appear necessari initi autoimmun coagulopathi | D001778;D000086382 | T047;T067 |
36,232,794 | cardiac mitochondria dysfunct dyslipidem mice dyslipidemia trigger mani sever patholog includ atherosclerosi chronic inflamm sever line evid includ studi suggest direct effect dyslipidemia cardiac energi metabol detail effect clear studi aim investig mild dyslipidemia affect cardiac mitochondria function vascular nucleotid metabol analys perform month old knock mice low densiti lipoprotein receptor ldlr compar wild type cblj mice wt cardiac isol mitochondria function analyz use seahors metabol flux analyz mechan function heart measur use echocardiographi level fusion fission mitochondri biogenesi protein determin elisa kit cardiac intracellular nucleotid concentr vascular pattern nucleotid metabol ecto enzym analyz use revers phase high perform liquid chromatographi reveal downregul mitochondri complex togeth decreas activ citrat synthas cs reduc level nuclear respiratori factor mitochondri fission protein well lower intracellular adenosin guanosin triphosph pool heart month ldlr mice vs age match wt analysi vascular ecto enzym pattern reveal decreas rate extracellular adenosin monophosph hydrolysi increas ecto adenosin deaminas activ eada month ldlr vs wt mice chang observ echocardiographi paramet age group ldlr mice younger hyperlipidem mice reveal differ cardiac mitochondria function cs activ intracellular nucleotid mitochondri biogenesi dynam exhibit minor chang vascular eada activ vs wt studi reveal dysfunct cardiac mitochondria develop prolong mild hyperlipidemia time point correspond format earli vascular alter | D000243;D006949 | T047;T126;T116;T033 |
36,232,793 | increas co occurr pathogen variant hereditari breast ovarian cancer lynch syndrom consequ multigen panel genet test probabl carri two pathogen variant pvs domin cancer predispos gene hereditari breast ovarian cancer lynch syndrom patient uncommon except popul founder effect exist two breast cancer women doubl heterozygot dh brcabrca one ovarian cancer case dh brcaradc anoth breast colorect cancer dh brcapm identifi cohort age diagnosi sever diseas brcabrca dh resembl brca singl carrier featur similar co exist brca pms mutat prompt develop breast colorect cancer patient first brcabrca dh identifi ha base sanger sequenc famili brca pvs howev ratio increas dh carrier vs singl pv carrier sinc use custom cancer gene demand panel type cancer develop dh patient consist independ inherit condit clinic outcom wors patient singl brca mutat therefor clinic impact especi patient two hereditari syndrom lie genet counsel tailor made famili base clinic guidelin syndrom number dh expect increas futur result next generat sequenc routin | D001943;D003123;D010051 | T191;T047 |
36,232,792 | survey comput method investig ncrna diseas associ mode action perspect molecular sequenc technolog success use decod biolog mechan various diseas reveal mani novel discoveri role non code rnas ncrnas understand diseas mechan becom increas import sinc ncrnas primarili act regul transcript associ ncrnas diseas involv multipl infer step leverag fast accumul high throughput screen result number comput model predict ncrna diseas associ develop tool suggest novel diseas relat biomark therapeut target ncrnas contribut realize precis medicin survey first introduc biolog role differ ncrnas summar databas contain ncrna diseas associ suggest new trend recent comput predict ncrna diseas associ mode action moa network perspect perspect includ integr ncrnas mrna pathway phenotyp inform next section describ comput methodolog wide use research domain exist comput studi summar term coverag moa network last discuss potenti applic futur role moa network term integr biolog mechan ncrna diseas associ | D019295;D022661 | T091;T114 |
36,232,791 | jellyfish polysaccharid wound heal applic jellyfish consid new potenti resourc food pharmaceut biomed industri latter case studi sourc activ principl also exploit produc marin collagen present work jellyfish skin polysaccharid jsp glycosaminoglycan gag featur extract rhizostoma pulmo main bloom speci mediterranean sea massiv augment climat lead jellyfish sea two main fraction r pulmo jsp rp jsps isol character name neutral fraction rp jsp sulphat rich negat charg fraction rp jsp two fraction averag molecular weight kda kda respect sugar composit evalu lc ms analysi result confirm presenc typic gag saccharid glucos galactos glucosamin galactosamin use promot wound heal evalu vitro scratch assay murin fibroblast cell line balbt clone human keratinocyt hacat rp jsps demonstr effect confluenc rate activ lead scratch repair two day promot cell migrat prolifer addit rp jsps exert substanti protect oxid stress result improv viabil treat fibroblast expos h isol gag like polysaccharid appear promis function compon biomed skin treatment well futur exploit pharmaceut excipi | D003063;D037401 | T204 |
36,232,790 | two case autoimmun thyroid disord covid vaccin dialysi patient sar cov infect vaccin associ autoimmun thyroid dysfunct autoimmuneinflammatori syndrom induc adjuv asia molecular mimicri refer potenti caus case report immunocompromis end stage renal diseas esrd patient herein present two dialysi patient previous histori thyroid diseas develop immun mediat thyroid disord bntb mrna vaccin sar cov first patient year old man hemodialysi diagnos grave diseas four month post vaccin second one year old femal periton dialysi develop hashimoto thyroid two month post vaccin grave diseas uncommon dialysi patient wherea hashimoto thyroid higher incid popul time proxim case suggest potenti causal knowledg first report de novo immun mediat thyroid disord dialysi patient follow vaccin sar cov | D000086382;D000086663;D006111;D050031 | T047;T200;T067 |
36,232,789 | gal nanoparticl mediat home endogen stem cell repair regener extern intern injuri local complement activ macrophag recruit review discuss novel experiment approach regener origin tissu structur recruit endogen stem cell injur site follow administr gal nanoparticl har natur anti gal antibodi anti gal produc larg amount human bind multipl gal epitop gal gal glcnac r present gal nanoparticl situ bind anti gal gal nanoparticl activ complement system generat complement cleavag chemotact peptid rapid recruit macrophag macrophag reach anti gal coat gal nanoparticl bind via fcfc receptor interact polar pro repar macrophag macrophag secret various cytokin orchestr regener injur tissu includ vegf induc neo vascular cytokin direct home stem cell injuri site home stem cell also direct interact complement cleavag peptid correspond receptor stem cell applic gal nanoparticl skin wound anti gal produc mice result decreas heal time half furthermor gal nanoparticl treat wound restor normal structur injur skin without fibrosi scar format similar mous model occlusionreperfus myocardi infarct near complet regener intramyocardi inject gal nanoparticl demonstr wherea heart inject salin display fibrosi scar format left ventricular wall suggest recruit stem cell follow anti gal gal nanoparticl interact injur tissu may result induct local regener facilit conduc microenviron generat pro repar macrophag secret cue provid extracellular matrix injuri site | D002921;D053758 | T046;T073 |
36,232,788 | genet disrupt guanylyl cyclasenatriuret peptid receptor trigger differenti cardiac fibrosi disord male femal mutant mice role tgf smad signal pathway global target disrupt natriuret peptid receptor npra gene npr mice provok hypertens cardiovascular dysfunct object studi determin mechan regul develop cardiac fibrosi dysfunct npr mutant mice npr knockout npr copi heterozyg npr copi wild type npr copi mice treat transform growth factor tgf receptor tgf r antagonist gw gg bodi weightday ip day heart isol use real time quantit revers transcript polymeras chain reaction qrt pcr western blot immunohistochem analys npr copi mice show fold induct cardiac fibrosi dysfunct mark induc express collagen fold monocyt chemoattract protein fold connect tissu growth factor ctgf fold smooth muscl actin sma fold tgf ri fold tgf rii fold phosphoryl small mother decapentapleg psmad protein includ psmad fold psmad fold compar wild type mice express phosphoryl extracellular regul kinas erk perk matrix metalloproteinas mmp prolifer cell nuclear antigen pcna also signific upregul npr copi mice treatment mutant mice gw signific block express fibrot marker smad protein mmps pcna compar vehicl treat control mice treatment gw signific prevent cardiac dysfunct sex depend manner npr copi copi mutant mice result suggest develop cardiac fibrosi dysfunct mutant mice predomin regul tgf mediat smad depend pathway | D006162;D053773 | T121;T126;T116;T123 |
36,232,787 | cultiv cryopreserv human dental pulp stem cell new approach maintain dental pulp tissu human dental pulp stem cell hdpscs multipot mesenchym stem cell mscs capabl self renew multilineag differenti potenti cryopreserv hdpscs report maintain high level prolifer multi differenti abil order optim cryopreserv techniqu decreas storag requir lower contamin risk feasibl new whole tooth cryopreserv effect hdpscs test surviv rate morpholog prolifer rate cell activ surfac antigen differenti abil hdpscs isol fresh teeth compar one month cryopreserv teeth dmso data present studi indic new cryopreserv approach reduc capabl stem hdpscs except extend first appear time hdpscs teeth cryopreserv dmso reduc recoveri rate novel strategi freez hdpscs still express typic surfac marker mscs maintain excel prolifer capac three consecut week osteogen adipogen induct also show express key gene hdpscs includ lipoprotein lipas lpl peroxisom prolifer activ receptor ppar alkalin phosphatas alp runt relat transcript factor runx type collagen col osteocalcin osc affect indic differenti abil remain intact crucial paramet hdpscs cell therapi candid result demonstr new cryopreserv method low cost effect good preserv hdpscs without compromis cell perform provid idea evid futur applic stem cell therapi establish dental bank | D050659;D008071 | T126;T123;T116 |
36,232,786 | new structur model apolipoprotein b base comput model cross link apob member larg lipid transfer protein superfamili one main apolipoprotein found low densiti lipoprotein ldl low densiti lipoprotein vldl particl despit clinic signific develop cardiovascular diseas limit inform apob structur develop novel method base divid conquer algorithm use psipr softwar divid apob five subunit domain model domain prepar use tasser demo rosettafold phyre model subsequ use disuccinimidyl sulfoxid dsso new mass spectrometri cleavabl cross linker known posit disulfid bond experiment valid model obtain uniqu dsso cross link within threshold final model also evalu posit cystein residu involv eight known disulfid bond apob pair measur within expect constraint final multipl domain combin appli constraint base detect long rang dsso cross link generat five subunit subsequ merg achiev uninterrupt architectur apob around lipoprotein particl moreov dynam apob particl size transit examin compar vldl ldl comput model use experiment cross link data addit propos model receptor ligand bind apob provid new insight function | D001055;D003545 | T121;T123;T116 |
36,232,785 | cellular biogenet law distort protein interact possibl unifi framework cancer biolog regen medicin biogenet law recapitul law state ontogenesi recapitul phylogenesi howev law distort modif develop show recapitul phylogenesi differenti various cell type use meta analysi human singl cell transcriptom control cell cycl activ improv phylostratigraphi gene date multipot progenitor differenti pluripot embryon stem cell esc show downregul unicellular uc gene upregul multicellular mc gene case origin euteleostomi boni vertebr pictur strike resembl evolutionari profil regulatori gene expans due gene duplic human genom recapitul phylogenesi induc pluripot stem cell ipsc differenti resembl esc pattern unipot erythroblast differenti erythrocyt show downregul uc gene upregul mc gene origin euteleostomi mc interactom neighborhood protein encod uc gene revers gene express pattern function analysi show evolv environ uc protein typic protein modifi signal relat protein besid fundament aspect approach provid unifi framework cancer biolog regenerativerejuven medicin oncogenesi defin atavist revers uc state regener rejuven requir ontogenet revers | D057026;D009369 | T191;T025 |
36,232,784 | pro apoptot anti invas properti underscor tumor suppress impact myoglobin subset human breast cancer cell express myoglobin mb well known oxygen storag transport protein myocyt novel hallmark lumin subtyp breast cancer patient correl better prognosi mechan mb impact mammari tumorigenesi hitherto unclear aim unravel role use crisprca technolog generat mb defici clone mcf skbr breast cancer cell line subsequ character transcriptom plus molecular function analys main find loss mb normoxia upregul express cell cyclin increas cell surviv prevent apoptosi mcf cell addit mb defici cell less sensit doxorubicin ioniz radiat hypoxia loss mb enhanc partial epitheli mesenchym transit thus augment migratori invas behavior cell notabl human invas mammari ductal carcinoma tissu mb apoptot marker level posit correl addit mb protein express invas ductal carcinoma associ posit prognost valu independ known tumor suppressor p conclus provid multipl line evid endogen mb cancer cell exert novel tumor suppress role reduc cancer malign | D001943 | T191 |
36,232,783 | cplot contig plot visual analysi short read nucleotid sequenc align advanc next generat sequenc technolog led dramat decreas read generat cost increas read output reconstruct short dna sequenc read generat next generat sequenc requir read align method reconstruct refer genom addit essenti analyz result read align biolog meaning infer howev read align vast amount genom data various organ challeng involv repeat automat manual analysi step devis cplot softwar read align nucleotid sequenc autom read align posit analysi allow visual assess analysi result user cplot compar sequenc similar read perform multipl read align fasta format file input applic provid web base interfac user facil implement without need dedic comput environ cplot identifi locat order sequenc read compar sequenc genet close refer sequenc way effect visual assembl short read generat ngs rapid gene map construct | D059014;D012984 | T073;T059;T063;T090;T170 |
36,232,782 | crisprca promis therapeut tool cure blind current scenario futur prospect crispr base target genom edit bring revolutionari chang research arena biolog scienc crisprca explor effici therapeut tool treatment genet diseas wide use ophthalmolog research use mous model correct pathogen mutat eye stem cell recent studi crisprca use correct larg number mutat relat inherit retin disord vivo therapeut advantag retin diseas success achiev rodent current advanc crispr base gene edit domain modifi cas variant deliveri approach optim applic treat blind review recent progress challeng crispr cas system discuss cure blind prospect | D064113;D000072669 | T063;T040 |
36,232,781 | genet analysi fine map zmght confer glufosin herbicid toler maiz zea may l weed interfer crop field one major biotic stress caus dramat crop yield loss develop herbicid resist crop critic weed control applic herbicid technolog identifi herbicid resist germplasm screen maiz inbre line seedl spray gl glufosin one plant lr possibl deriv natur variat line l identifi potenti glufosin toler genet analysi valid glufosin toler lr confer singl locus tentat design zmght construct bi parent popul deriv lr glufosin sensit line l zmght map molecular marker interest genom compar two sequenc refer genom show larg scale structur variat svs occur within map region result mb inbre line b kb cml respect fine map process detect addit recombin even use f f plant suspect svs also occur lr l region inhibit recombin evalu express gene within map interv use function annot predict gene zmeb encod aminotransferas like causat gene glufosin treatment lower level ammonia content higher activ glutamin synthetas gs lr detect compar l l suggest target gene may particip ammonia elimin involv gs activ collect studi provid materi resourc maiz herbicid resist breed potenti reveal new mechan herbicid resist | D006540 | T131 |
36,232,780 | lipid alter associ metformin healthi subject investig use mass spectrometri shotgun approach metformin oral effect insulin sensit drug wide prescrib treat type diabet mellitus tdm metformin report alter lipid metabol howev molecular mechan behind impact lipid metabol remain partial explor understood current studi mass spectrometri base lipid profil use investig lipidom chang serum healthi individu singl dose intak metformin sampl analyz five time point preadministr maximum concentr metformin cmax cmax cmax h post administr total molecul signific alter five time point base comparison baselin level cmax metformin signific increas decreas level lipid respect fdr fold chang cutoff alter lipid main involv arachidon acid metabol steroid hormon biosynthesi glycerophospholipid metabol furthermor sever lipid act oppos similar manner metformin level includ fatti acyl sterol lipid glycerolipid glycerophospholipid signific alter lipid speci point fundament lipid signal pathway could link pleiotrop effect metformin tdm insulin resist polycyst ovari syndrom cancer cardiovascular diseas | D003924;D007333;D008687;D011085 | T121;T047;T046;T109 |
36,232,779 | root relat gene crop applic drought stress resist review crop growth develop frequent affect biotic abiot stress adapt crop stress most achiev regul specif gene root system primari organ nutrient water uptak import role drought stress respons improv stress toler increas crop yield potenti yield stabil tradit goal breeder cultivar develop use integr breed method improv understand gene control root develop enabl formul strategi incorpor stress toler gene breed complex agronom trait provid opportun develop stress toler germplasm screen gene associ root growth develop divers plant includ arabidopsi rice maiz pepper tomato paper provid theoret basi applic root relat gene molecular breed achiev crop drought toler improv root architectur | D017360;D055864 | T002;T070 |
36,232,778 | earli detect cervic cancer fluoresc lifetim imag microscopi combin unsupervis machin learn cervic cancer high morbid mortal rate affect hundr thousand women worldwid requir accur screen earli intervent follow treatment cytolog current domin clinic screen approach though use decad unsatisfactori sensit specif work fluoresc lifetim imag microscopi flim use imag exfoli cervic cell endogen coenzym involv metabol name reduc nicotinamid adenin dinucleotid phosphat nad p h detect evalu metabol status cell flim imag particip analyz unsupervis machin learn method build predict model cervic cancer risk flim method combin unsupervis machin learn flim ml sensit specif respect signific higher cytolog approach one cancer recurr case predict high risk sever month earlier use method compar use current clinic method impli flim ml may help follow cancer care studi illustr clinic applic flim ml detect method cervic cancer screen conveni tool follow cancer care | D009243;D002583 | T121;T191;T123;T114 |
36,232,777 | apoptot bodi rich media tenocyt enhanc prolifer migrat tenocyt bone marrow stromal cell intrins heal follow tendon injuri ideal tendon progenitor cell prolifer migrat injuri site direct bridg regener tendon tissu howev mechan determin cell attract injuri site tendon heal understood sinc tenocyt near injuri site go apoptosi necrosi follow injuri hypothes secret injur tenocyt might biolog effect cell prolifer migrat enhanc tendon heal tenocyt apoptosi induc h cell starvat apoptot bodi rich media abrm apoptot bodi deplet media abdm collect cultur media centrifug tenocyt bone marrow deriv stem cell bmdscs isol cultur follow four media abrm abdm gdf basal medium fetal calf serum fcs cell activ function evalu abrm abdm treatment signific stimul cell prolifer migrat extracellular matrix synthesi tenocyt bmdscs compar control group gdf basal medium howev cell prolifer migrat extracellular matrix product abrm treat cell signific higher abdm indic apoptot bodi critic cell activ studi reveal possibl mechan intrins heal tendon apoptot bodi process apoptosi follow tendon injuri promot tenocyt stromal cell prolifer migrat product futur studi analyz compon apoptot bodi play role thus target therapeut develop | D000067128;D059630;D013708 | T026;T025;T037 |
36,232,776 | pacbio full length illumina transcriptom gill reveal molecular respons corbicula fluminea aerial exposur air exposur common stress corbicula fluminea econom import freshwat shellfish consum china aquacultur transport howev littl known molecular respons air exposur therefor studi use combin pacbio full length illumina transcriptom investig molecular respons air exposur total transcript obtain use pacbio sequenc structur analysi identifi code sequenc transcript factor simpl sequenc repeat long non code rnas subcellular local analysi show transcript locat cytoplasm nucleus h air exposur differenti express gene deg gill obtain via illumina sequenc among deg gene relat glycolysi tricarboxyl acid cycl lipid metabol amino acid metabol upregul addit mani deg associ immun cytoskeleton reorgan autophagi ferroptosi identifi find indic metabol strategi chang immun respons cytoskeleton reconstruct autophagi ferroptosi might import mechan c fluminea use cope air exposur studi enrich gene resourc c fluminea provid valuabl data studi molecular mechan cope air exposur c fluminea freshwat mollusk | D049874;D014874 | T131;T204 |
36,232,775 | tissu engin acoustophoret tea set enhanc osteogen differenti murin mesenchym stromal cell mmscs quick develop precis medicin patient orient treatment strategi urgent requir novel technolog solut random cell popul scaffold usual use tissu engin often fail mimic high anisotrop characterist nativ tissu work ultrasound stand wave base tissu engin acoustophoret tea set develop organ murin mesenchym stromal cell mmscs situ polymer fibrin hydrogel result construct consist cell layer space obtain continu wave ultrasound appli mhz frequenc pattern mmscs preserv structur behavior within day cultur osteogen condit cell viabil moder increas day pattern subdu even cell random encapsul hydrogel within day cultur cell structur hydrogel exhibit enhanc express certain osteogen marker ie runt relat transcript factor runx osterix osx transcript factor collagen alpha cola osteopontin opn osteocalcin ocn osteonectin well certain cell cycl progress associ gene ie cyclin cystein rich angiogen induc cyr anillin anln cultur osteogen supplement anln also expans media addit opn express also augment day pattern gel cultur without osteoinduct media suggest pro osteogen influenc pattern cell organ tea set propos novel method non invas organ cell environ potenti enhanc regen properti design anisotrop construct bone heal | D059630;D010012 | T025;T042 |
36,232,774 | ar express correl distinct clinicopatholog genom featur breast cancer regardless esr express status androgen receptor ar express frequent observ breast cancer associ estrogen receptor er express breast cancer remain unclear studi analyz clinicopatholog molecular featur associ ar negat er posit er negat breast cancer tri elucid molecular correl ar er result show ar negat associ differ clinicopatholog characterist molecular featur er posit er negat breast cancer moreov ar posit breast cancer better clinicopatholog featur ar negat breast cancer especi er negat subtyp result suggest role ar er negat breast cancer distinct er posit breast cancer | D001943;D011944 | T191;T116;T192 |
36,232,773 | target sequenc cytokin induc pik relat gene ulcer coliti colorect cancer coliti associ cancer chronic relaps inflammatori bowel diseas strong link increas risk coliti associ cancer cac one well known inflammatori carcinogenesi pathway phosphatidylinositol kinas pik identifi crucial mechan long stand ulcer coliti uc goal studi identifi somat variant cytokin induc pik relat gene uc colorect cancer crc cac thirti biopsi n long stand uc n crc n pair normal colorect mucosa n cac subject target sequenc pik relat gene use illumina sequenc sureselectxt target enrich system genom analysi toolkit use analyz variant annovar employ detect annot intron exon untransl region utr noncod intron variat detect across sampl apart small number frameshift distribut missens synonym variant almost equal discov chang level ilr ilr ilr tyk jak osmr sampl ilr variant utr region rs identifi possibl variant might potenti connect cac uc crc addit secondari structur predict use rnafold reveal mutant structur unstabl wildtyp structur function research potenti variant therefor high recommend sinc may provid insight relationship inflamm cancer risk cytokin induc pik pathway | D003093;D000083023;D015179;D016207;D058539 | T047;T116;T191;T126;T129 |
36,232,772 | investig transcriptom pattern endometri cancer obes lean women endometri cancer common gynaecolog malign develop countri one largest risk factor endometri cancer obes aim studi determin whether differ transcriptom endometri cancer obes vs lean women investig transcriptom endometri cancer obes lean postmenopaus women use rrna deplet rna seq data endometri cancer tissu match adjac non cancer endometri tissu differenti express analysi identifi gene regul regul endometri cancer tissu obes women gene regul regul endometri cancer tissu lean women adjust p valu lt gene ontolog enrich analysi reveal top regul gene adjust p valu enrich growth prolifer pathway top regul gene enrich cytoskeleton restructur network obes lean endometri cancer tissu studi also show perturb express protein code gene histhbl histhf histhbh histhb ttk ptchd aspn prelp cdh lncrna mbnl endometri cancer tissu overal studi identifi gene express chang similar also uniqu endometri cancer obes vs lean women furthermor gene may serv prognost biomark possibl therapeut target endometri cancer | D016889;D009765;D062085;D013851;D059467 | T047;T086;T081;T191;T123;T114;T033 |
36,232,771 | applic mask air app sever asthma treat biolog molecul pilot studi mask air good practic dg sant fulli valid allerg rhiniti littl known applic asthmat explor whether mask air applic applic patient sever asthma sever asthmat propos use mask air applic month along best practic treatment treatment patient chang base applic result evolut visual analogu scale vas asthma short breath rhiniti conjunct work sleep monitor use mask air adher mask air asthma treatment also check thirteen patient report day mask air use averag applic adher rang correl applic medic adher high variabl trend found vas asthma five patient well control day four well moder control asthma uncontrol day one patient moder control asthma approxim uncontrol day one patient uncontrol day high signific correl found vas asthma patient report vass work dyspnea sleep rhiniti mask air use patient sever asthma vas asthma appear interest patient report outcom high correl dyspnea impact work adher applic better rhiniti need improv | D001249;D001688;D063731;D012220;D065631 | T121;T047;T170;T123 |
36,232,770 | hepat sam regul system glucos homeostasi insulin sensit hepat glucos product hgp import compon glucos homeostasi deregul hgp particular gluconeogenesi contribut hyperglycemia patholog type diabet td shown gluconeogen gene express govern primarili transcript factor camp respons element cre bind protein creb coactiv creb regul transcript coactiv crtc recent discov sam adaptor protein src kinas substrat potent promot hepat gluconeogenesi promot crtc stabil howev detail mechan remain unclear show respons glucagon sam increas crebcrtc transact interact crtc crebcrtc complex occupi cre motif promot lead gluconeogen gene express glucos product hepatocyt glucagon promot sam nuclear import wherea insulin elicit nuclear export furthermor ablat sam hepatocyt protect mice high fat diet hfd induc hyperglycemia signific increas hepat peripher insulin sensit thus hepat sam potenti crebcrtc mediat glucos product contribut pathogenesi insulin resist may serv therapeut target td | D048868;D003924;D005943;D005947;D022781;D007333;D016601 | T047;T046;T116;T121;T109;T123;T025;T044 |
36,232,769 | znt critic tlr mediat cytokin express colonocyt modul mucos inflamm mice wide rang microbi pathogen enter gastrointestin tract caus mucos inflamm infecti coliti account case acut diarrhea sever case infecti coliti persist week untreat may lead major complic death molecular pathogenesi microbi infect often well character host associ epitheli factor affect risk sever infecti coliti less well understood current studi character function zinc zn transport znt slca cultur ht colonocyt determin consequ znt delet mice colon respons enter infect citrobact rodentium znt colonocyt transport zn vesicl buffer cytoplasm zn pool import toll like receptor tlr express activ pathogen stimul nf transloc cytokin express addit znt critic lysosom biogenesi bacteri induc autophagi promot robust host defens resolut mechan respons enter pathogen find reveal znt novel regul mucos inflamm colonocyt critic respons infecti coliti suggest manipul function znt may offer new therapeut strategi treat specif intestin infect | D027682;D003092;D007249;D007413;D051197 | T047;T046;T023;T116;T192;T123;T024 |
36,232,768 | lacpg hl function effect antibiot free healthi husbandri improv innat immun antibiot broad restrict modern husbandri farm necessit need effici low cost immunomodulatori prepar antibiot free health farm known cpg oligonucleotid cpg odn effect innat immunostimulatori agent recogn tlr mammal tlr avian could collabor unit agent induc stronger immun respons cost prohibit expens farmer consid coordin tlr tlrtlr first propos idea well ferment lactococcus lacti could util cpg plasmid carrier lacpg enhanc host innat immun pathogen invas present studi obtain lacpg hl homogen lyophil recombin strain lacpg treat primari chicken lymphocyt two cell line hd ipec j chicken lacpg hl cpg plasmid pnz cpg stimul respect confirm effect conduct qrt pcr bacteri infect assay zoolog experi data show lacpg hl could induc excel innat immun regul autophagi reaction cytokin express motiv prrs interest despit direct antisept effect lacpg hl improv antibacteri capac lymphocyt enterocyt first line defens import water suppli lacpg hl treatment reduc averag advers event rate demonstr lacpg hl maintain excel immunostimulatori protect properti farm condit research contribut reveal satisfactori effect lacpg hl also shed new light cost effect solut optim immun effect green antibiot free health husbandri farm | D000891;D051217 | T121;T192;T116;T129 |
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