PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,767 | preconcentr separ gold nanoparticl environment water use extract techniqu follow spectrometr quantif quantif gold nanoparticl aunp environment sampl ultratrac concentr accur perform sophist pricey analyt method paper aim challeng analyt potenti advantag cheaper equal reliabl altern coupl well establish extract procedur common spectrometr method discuss sever combin techniqu suitabl separationpreconcentr quantif aunp complex challeng aqueous matric tap river lake brook miner sea water well wastewat cloud point extract cpe success combin electrotherm atom absorpt spectrometri etaa induct coupl plasma mass spectrometri icp ms chemiluminesc cl total reflect x ray fluoresc spectrometri txrf major advantag approach abil quantifi aunp differ size coat sampl volum order millilit small volum sampl ml dispers solvent l extract agent l report also surfact assist dispers liquid liquid microextract sa dllme coupl electrotherm vapor induct coupl plasma mass spectrometri etv icp ms limit detect lod achiev use differ combin method well enrich factor ef vari great ng l respect | D006046;D053768 | T121;T196;T073 |
36,232,766 | understand function mechan zebrafish tmemb regul cold resist autophagi endoplasm reticulum er stress respons among key pathway regul cold resist fish elimin damag cellular compon facilit restor cell homeostasi upon exposur acut cold stress transmembran protein tmema report regul autophagi er stress respons vertebr specif paralog transmembran protein b tmemb character current studi generat tmemb knockout zebrafish line character surviv abil acut cold stress observ dysfunct tmemb remark decreas cold resili larval adult zebrafish gene transcript larva expos cold stress rewarm character rna sequenc rna seq explor mechan under function tmemb regul cold resist result indic defici tmemb attenu regul cold rewarm induc gene cold induc transcript factor gene bif fosab egr rewarm activ immun gene ca ila sting repres influenc tmemb dysfunct howev loss tmemb littl effect transcript er stress respons autophagi relat gene measur phosphoryl ha histon famili member x ser abbrevi hax demonstr zebrafish tmemb protect cell dna damag caus exposur cold warm stress facilit tissu damag repair recoveri phase gene modul under function tmemb zebrafish high enrich biolog process associ immun respons dysfunct tmemb also attenu regul tissu c reactiv protein crp content upon rewarm togeth data shed new light function mechan tmemb regul cold resist fish | D002097;D015027 | T116;T013;T129 |
36,232,765 | genom wide copi number variant high throughput transcriptom analys placent tissu underscor persist child suscept risk pregnanc clear standard genet test sever studi shown children pregnanc estim first trimest risk base fetal nuchal transluc thick abnorm matern serum pregnanc protein hormon level maintain higher likelihood advers outcom even initi test known genet condit negat use finnish intrauterin cohort itu comprehens character perinat cohort consist mother babi follow throughout pregnanc month postnat includ mother shortlist prenat genet test clear major aneuploidi case n control pregnanc n use genom wide genotyp rna sequenc first trimest term placent tissu combin medic inform registri data matern self report data investig potenti negat medic outcom genet suscept diseas correl placenta gene express case mother present higher level depress perceiv stress anxieti pregnanc case children signific diagnos often congenit malform circulatori system ci higher hazard present signific copi number duplic compar control burden analysi base copi number variant cnvs frequenc call duplic case versus call duplic control p fifteen gene show differenti gene express fdr lt associ congenit malform first trimest term placenta signific enrich gene associ placent dysfunct spite normal routin follow prenat test result earli pregnanc case children present increas likelihood negat outcom prompt vigil follow pregnanc birth | D056915;D011248 | T046;T045;T086 |
36,232,764 | cellular molecular biolog alter photon proton carbon ion irradi human chondrosarcoma cell link high qualiti physic data chondrosarcoma particular difficult treat due resist chemotherapi radiotherapi howev particl therapi enhanc local control patient surviv rate improv understand basic cellular radiat respons function dose linear energi transfer let develop novel water phantom base setup cell cultur experi character dosimetr direct comparison human chondrosarcoma cell line analyz regard viabil cell prolifer cell cycl dna repair behavior irradi x ray proton carbon ion result clear show cell viabil prolifer inhibit accord increas ionize densiti ie let irradi mode furthermor promin g arrest shown gene express profil prove upregul senesc gene cdkna p cdkna pnka bmi foxo particl irradi proton c ion irradi caus posit regul repair gene atm nbn atxr xpc high signific increas xrcc ercc xpc pcna express c ion appear activ dna repair mechan effect link physic data cellular respons import contribut improv treatment system | D002813;D011522 | T191;T196 |
36,232,763 | eco friend solut base rosmarinus officinali hydro alcohol extract prevent biodeterior cultur heritag object build biodeterior cultur heritag caus differ organ capabl induc complex alter process present studi aim evalu effici rosmarinus officinali hydro alcohol extract inhibit growth deteriogen microbi strain physico chemic character veget extract uhplc msms antimicrobi antibiofilm activ repres number biodeteriogen microbi strain well antioxid activ determin dpph cuprac frap teac method perform extract total phenol content mg gaeml approxim flavonoid polyphenol profil includ carnos acid carnosol rosmarin acid hesperidin major compon extract exhibit good wide spectrum antimicrobi activ low mic minim inhibitori concentr valu fungal strain aspergillus clavatus mic mgml bacteri strain arthrobact globiformi mic mgml bacillus cereus mic mgml rosemari extract inhibit adher capac inert substrat penicillium chrysogenum strain isol wooden object textil b thuringiensi strain potenti mechan r officinali antimicrobi activ could repres releas nitric oxid univers signal molecul stress manag moreov treatment microbi cultur subinhibitori concentr modul product microbi enzym organ acid involv biodeterior effect depend studi microbi strain isol sourc test solubl factor paper report first time potenti r officinali hydro alcohol extract develop eco friend solut dedic conservationsafeguard tangibl cultur heritag | D000890;D006569;D027542 | T121;T109;T127;T002 |
36,232,762 | high branch betulin base polyanhydrid self assembl micellar nanoparticl formul polyanhydrid base betulin promis materi use control drug deliveri system due broad biolog activ betulin deriv lack toxic vitro vivo polym use polymer prodrug carrier biolog activ compound studi develop novel amphiphil branch polyanhydrid synthes two step melt polycondens betulin disuccin dbb tricarboxyl deriv poli ethylen glycol pegcooh dbb pegcooh use hydrophob hydrophil segment respect content dbb copolym wt copolym assess cytostat activ various cancer cell line compar linear dbb peg base polyanhydrid branch polyanhydrid exhibit higher anticanc activ obtain polym abl self assembl water form micell hydrodynam diamet nm stabl concentr rang gml mgml form micell found spheric shape use scan electron microscop found structur composit polyanhydrid affect hydrodynam diamet micell branch betulin base polyanhydrid potenti serv biodegrad polym prodrug carrier bioactiv compound | D054697;D053758;D049388;D011355 | T121;T104;T073;T120 |
36,232,761 | whole exom sequenc multi incid famili identifi novel candid gene multipl sclerosi multipl sclerosi ms degen diseas central nervous system auto immun induc demyelin occur ms thought caus complex interplay environment genet risk factor genet studi focus identifi common genet variant ms genom wide associ studi object present studi identifi rare genet variant contribut ms suscept use whole exom sequenc wes follow co segreg analys nine multi incid famili two four affect individu wes perform famili member without ms appli suit select criteria co segreg analys number rare variant select wes result perform ad famili member approach result exon rare variant show accept co segreg ms within nine famili implic gene mbp plk mecp mtmr tox cpta sorc trim itpr ttc cacnaf pram three gene mbp mecp cpta previous report carri ms relat rare variant six addit gene mtmr tox sorc itpr ttc pram also implic ms common genet variant protein encod twelv gene contain rare variant interact molecular framework point biolog process involv de myelin auto immun approach provid clue possibl molecular mechan under ms studi cellular andor anim model | D055106;D009103 | T047;T063 |
36,232,760 | stem cell clinic trial neurolog disord trend stem cell origin indic status clinic trial neurolog diseas signific reduc qualiti durat life stem cell provid promis solut due regen featur also varieti function includ reduc inflamm promot angiogenesi although hematopoiet cell approv fda far number trial continu expand analyz clinic trial illustr trend stem cell origin indic phase status clinic trial common neurolog disord treat stem cell injuri brain spinal cord peripher nerv stroke multipl sclerosi brain tumor mesenchym stem cell domin although choic stem cell high depend neurolog disord trial two trial reach phase trial phase transit base comparison obtain result similar work analysi literatur discuss challeng futur direct stem cell therapi treatment neurolog diseas | D059630;D009103;D009422 | T025;T047 |
36,232,759 | platelet gaug liver diseas kinet multitud laboratori clinic interfer influenc util platelet base diagnost indic includ immatur platelet fraction longitudin monitor prognost patient chronic liver diseas cld complex yet high regul molecular basi platelet product clearanc kinet becom dysregul liver pathogenesi under molecular mechan includ prematur platelet clearanc bone marrow suppress parallel progress eg treatment nave regress eg treatment treatment diseas cours involv clds may confound chang platelet liver correl time platelet count function common secondarili alter vivo clds howev precis character platelet function cirrhosi includ vitro platelet aggreg proven challeng due interfer thrombocytopenia flow cytometr approach may help monitor unstabl rebalanc hyper hypoaggreg state patient cirrhosi risk hyperaggreg prothrombot bleed event studi attempt stratifi patient cirrhosi substag prognosi use novel indic ratio vitro endogen platelet aggreg platelet count review attempt highlight clinic laboratori precaut context platelet assist cld monitor | D001792;D008107 | T025;T047;T033 |
36,232,758 | measur hepat cypa activ use radioiodin label desmethylvenlafaxin drug metabol enzym activ affect various factor drug drug interact method quantifi drug metabol enzym activ real time need studi develop novel radiopharmaceut quantit imag estim hepat cypa cypd activ iodin label desmethylvenlafaxin odv obtain high label puriti metabol found strong involv cypa cypd spect imag normal mice show administ odv accumul earli liver excret gallbladd evalu time activ curv biolog distribut odv administ mice accumul earli liver metabolit odv quick excret bile cypa cypd inhibit model mice accumul bile decreas normal mice indic inhibit metabolit product result indic imag quantifi accumul radioact metabolit excretori organ aid determin dosag various drug metabol cypa cypd individu medicin thus odv potenti direct comprehens detect measur hepat cypa cypd activ simpl less invas approach | D019389;D051544;D007457;D008099 | T023;T116;T131;T126;T196 |
36,232,757 | macropor regul hydroxyapatit osteoinduct via microfluid pathway macropor characterist shown play key role osteoinduct hydroxyapatit ceram physic under new bone format distribut scaffold still remain elus work emphas osteoinduct capac porous hydroxyapatit scaffold contain differ macropor size geometri star shape spheric shape assumpt size shape macropor structur may affect microfluid pathway scaffold result differ bone format distribut herein mathemat model anim experi propos support hypothesi result show porous scaffold spheric macropor larg pore size higher new bone product uniform new bone distribut other finit element analysi suggest macropor shape affect distribut medium high veloc flow field macropor size effect microfluid speed valu shear stress scaffold addit result scaffold implant dorsal muscl higher new bone mass abdomin caviti suggest mechan load host tissu could play key role microfluid pathway mechan find suggest osteoinduct scaffold depend microfluid veloc shear stress generat macropor size shape studi therefor provid new insight inher osteoinduct mechan bioceram may offer clue toward ration design bioceram scaffold improv osteoinduct | D017886;D054457 | T121;T122;T197 |
36,232,756 | plastic toward rigid macrophag conundrum pulmonari fibrosi idiopath pulmonari fibrosi ipf progress chronic ultim fatal diffus parenchym lung diseas molecular mechan fibrosi ipf patient fulli understood lack effect treatment decad differ type drug immunosuppress antioxid test usual unsuccess result although two antifibrot drug nintedanib pirfenidon approv use treatment ipf side effect common slow diseas progress without improv patient surviv macrophag central lung homeostasi wound heal injuri depend stimulus microenviron macrophag may contribut fibrosi also may play role amelior fibrosi review explor role macrophag ipf relat fibrot process epitheli mesenchym transit emt crosstalk resid recruit cell emphas import macrophag find new treatment | D054990 | T047 |
36,232,755 | hsp myokin associ system inflamm exercis intervent patient myositi healthi subject compel evid support health benefit physic exercis immun system possibl molecul secret skelet muscl known myokin herein assess impact exercis intervent plasma heat shock protein hsp level patient idiopath inflammatori myopathi iim compar iim patient treat standard care immunosuppress therapi healthi subject undergo strenuous eccentr exercis associ tradit serum marker muscl damag inflamm contrast iim patient treat pharmacotherapi demonstr signific decreas hsp week week exercis program result stabil hsp level chang hsp level associ chang sever inflammatori cytokineschemokin involv pathogenesi iim muscl regener general strenuous eccentr exercis healthi volunt induc brief increas hsp level subsequ return baselin level day exercis less pronounc correl system inflamm studi identifi hsp potenti myokin mediat exercis induc immun respons potenti biomark predict improv physiotherapi muscl endur iim | D005081;D018841;D007249;D018482;D009220 | T023;T046;T047;T116;T061;T123;T024 |
36,232,754 | novel thieno b pyridin anticanc compound lower cancer stem cell fraction induc shift lipid glucos metabol due role cancer stem cell cscs tumor resist glycosphingolipid gsl involv tumor pathogenesi investig effect newli synthes compound amino n chloro methylphenyl oxo tetrahydrothieno b quinolin carboxamid percentag cscs express six gsls cscs non cscs breast cancer cell line mda mb mcf also investig effect metabol profil cell line mtt assay use cytotox determin apoptosi express gsls assess flow cytometri gc ms coupl system use separ identif metabolit compound cytotox cell line major cell die treatment induc apoptosi percentag cscs signific lower mda mb cell line treatment caus decreas csc iv neu ac nlc cer mda mb cell mcf cell line percentag galnac gmb cscs increas express gg cer decreas csc non csc twenti one metabolit identifi metabol profil major impact treatment glycolysisgluconeogenesi pyruv inositol metabol compound exhibit higher potenc mba mb cell deserv examin | D000970;D001943;D011804 | T121;T109;T191 |
36,232,753 | spin crossov slow magnet relax behavior hexachlororhen iv salt mn iii complex mn hal sal recl hal cl br cation complex mn iii hal sal hal cl br ligand paramagnet doubli charg counterion recl synthes mn cl sal recl mn br sal recl crystal structur magnet properti studi isostructur two compon ionic compound show thermal induc spin transit high temperatur associ cation subsystem field induc slow magnet relax magnet cryogen temperatur associ anion subsystem compound first exampl coexist spin crossov field induc slow magnet relax famili known mn iii sal cation complex various counterion | D009942;D012492 | T104;T109 |
36,232,752 | singl cell chromatin access data combin gwas improv detect relev cell type complex phenotyp sever diseas risk variant resid non code region dna particular open chromatin region specif cell type identifi cell type relev complex trait integr chromatin access data genom wide associ studi gwas data help elucid mechan trait studi creat collect associ combin chromatin access data bulk singl cell array complex phenotyp integr gwas data phenotyp bulk chromatin access data cell type measur dnase hypersensit sequenc found signific result fdr adjust p valu least one cell type complex phenotyp atop dermat grave diseas bodi mass index integr singl cell chromatin access data measur assay transposas access chromatin high throughput sequenc scatac seq taken adult fetal cell type resolut associ magnifi enabl identif cell type result identif signific correl fdr adjust p valu categori singl cell subtyp phenotyp rang autoimmun diseas like grave diseas cardiovascular trait like diastolicsystol blood pressur | D002843;D006111 | T047;T116 |
36,232,751 | explor amodiaquin repurpos potenti breast cancer treatment assess vitro efficaci mechan action due heterogen breast cancer current avail treatment option moder effect best henc high recommend comprehend differ subtyp understand pathogen mechan involv develop treatment modal repurpos old fda approv anti malari drug amodiaquin aq present outstand opportun explor efficaci treat major breast cancer subtyp cytotox scratch assay vasculogen mimicri studi clonogen assay employ determin aq abil inhibit cell viabil cell migrat vascular format coloni growth spheroid cell cultur studi perform identifi tumor growth inhibit potenti aq mcf mdamb cell line apoptosi assay cell cycl analysi rt qpcr assay western blot studi perform determin aq abil induc apoptosi cell cycl chang gene express chang induct autophagi marker protein result vitro studi confirm potenti aq anti cancer drug differ breast cancer cell line test aq signific induc cytotox inhibit coloni format inhibit cell migrat reduc spheroid volum induc apoptosi block cell cycl progress inhibit express cancer relat gene induc lcbii protein inhibit autophagi result demonstr amodiaquin promis drug repurpos breast cancer treatment need numer effort studi | D000962;D000970;D001943 | T121;T109;T191 |
36,232,750 | two conserv amino acid character island domain essenti biolog function brassinolid receptor brassinosteroid brs play import role plant growth develop br percept pivot process requir trigger br signal angiosperm br insensit bri essenti br receptor mutant exhibit extrem dwarf phenotyp arabidopsi two br receptor bri like brl bri like brl shown indispens br receptor requir island domain id respons br percept howev biolog function signific residu id remain unknown base crystal structur sequenc align analysi br receptor identifi two residu atbri high conserv within br receptor diversifi among differ br receptor residu tyrosin bri brlbrl fix two phenylalanin experiment find reveal except briyf briyf substitut residu remain amino acid differ impair br signal surpris briyf show weaker phenotyp briy impli residu key site differenti br receptor non br receptor essenti br receptor bri brl possibl result posit select via gain function evolut | D017360;D029681 | T116;T002 |
36,232,749 | antidepress like activ effect recognit memori deficit bioavail safeti chronic administr new dual act small compound target neuropsychiatr symptom dementia studi aim extend bodi preclin research prototyp dual act compound combin pharmacophor relev inhibit cyclic nucleotid phosphodiesteras pdea serotonin ht ht receptor ht r ht r activ singl chemic entiti compound pqa az pqa az iv administr pqa az pqa az rat brain plasma ratio respect ig administr brain plasma ratio respect antidepress like effect observ pqa az forc swim test chronic day treatment via ip administr mgkgday compound reveal increas level brain deriv neurotroph factor bdnf mrna hippocampus prefront cortex moreov pqa az pqa az complet revers mk induc memori disturb compar potent pde inhibitor compound pq safeti profil includ measur plasma glucos triglycerid total cholesterol concentr liver enzym activ total antioxid activ serum togeth weight gain compound exhibit signific activ howev studi compound differ effect human normal fibroblast cell reveal vitro assay pharmacokinet biochem result support notion novel dual act compound might offer promis therapeut tool cns relat disord | D019208;D003704 | T123;T116;T048 |
36,232,748 | esketamin psilocybin comparison two mind alter agent depress treatment systemat review public discuss two compound belong psychoact substanc group studi context depress treatment psilocybin esketamin former natur occur psychedel latter invent laboratori exact year ago although substanc controversi past recent studi indic potenti substanc novel antidepress agent pubmedmedlin databas use identifi articl systemat review use follow search term depress psilocybin ketamin item articl obtain final analys three articl devot psilocybin depress treatment nine esketamin studi esketamin show signific reduct depress symptom suicid ideat short intak month treatment compar baselin standard care antidepress agent psilocybin antidepress effect occur one day intak week treatment maintain month follow one studi indic psilocybin effect compar may superior escitalopram treatment esketamin psilocybin demonstr rapid long term effect reduc depress symptom overcom limit may consid novel antidepress agent futur | D061218;D006213;D007649 | T121;T109;T131;T048 |
36,232,747 | atlas thyroid hormon receptor target gene mous tissu gather avail rna seq chip seq data singl databas better character target gene thyroid hormon receptor sever cell type databas serv resourc analyz mode action thyroid hormon addit easi use conveni tool obtain inform specif gene regard regul extract larg gene list interest accord user criteria overal atlas uniqu compil recent sequenc data focus receptor mode action target role may benefit research within field preliminari analysi indic extens variat repertoir target gene transcript upregul chromatin bound nuclear receptor although major influenc chromatin access paramet determin cellular select hormon respons | D011988;D013963 | T116;T125;T192 |
36,232,746 | platelet redox imbal hypercholesterolemia big problem small cell imbal reactiv oxygen speci ros synthesi scaveng anti oxid defenc common soil mani disord includ hypercholesterolemia platelet smallest blood cell deepli involv pathophysiolog occlus arteri thrombi associ myocardi infarct stroke great deal evid show increas intraplatelet ros synthesi impair ros neutral implic thrombot process hypercholesterolemia recogn caus atherosclerosi cerebro cardiovascular diseas close relat widespread accept strong contribut platelet hyperreact via direct oxid ldl oxldl platelet membran interact via scaveng receptor cd signal pathway includ src famili kinas sfk mitogen activ protein kinas mapk nicotinamid adenin dinucleotid phosphat nadph oxidas turn activ platelet contribut oxldl generat end propag platelet activ thrombus format mechan mediat oxid stress evalu effect lipid lower therapi thrombogenesi larg bodi evid show effect statin proprotein convertas subtilisinkexin type inhibitor limit reduct ldl c also regul platelet reactiv main mechan sensit intracellular redox balanc review focus role oxid stress relat mechan caus platelet hyperreact pathophysiolog link pleiotrop lipid lower agent benefici effect platelet function | D019161;D006937;D006949;D013927 | T047;T046;T121;T109;T033 |
36,232,745 | lead disrupt mitochondri morpholog function induct er stress model neurotox lead exposur may weaken abil learn memori nervous system mitochondri paramorphia dysfunct howev under mechan fulli elucid work sd rat primari cultur hippocamp neuron pc cell line model built behavior test perform determin learn memori insult western blot immunolog stain electron microscop conduct determin endoplasm reticulum stress mitochondri paramorphia dysfunct co immunoprecipit perform investig potenti protein protein interact result show lead exposur may crippl rat learn memori capabl induc endoplasm reticulum stress mitochondri paramorphia dysfunct furthermor clarifi enhanc mfn ubiquitin degrad mediat pink may account mitochondri paramorphia endoplasm reticulum stress work may provid import clue research mechan pb exposur lead nervous system damag | D007854;D020258 | T131;T196;T037 |
36,232,744 | cb ligand induc weight loss fat reduct addit increas system inflamm diet induc obes diet induc obes dio reduc fatti acid oxid skelet muscl decreas circul level adiponectin endocannabinoid signal overact obes effect abat antagon cannabinoid receptor cb research aim determin treatment global cb antagonistinvers agonist high fat diet hfd fed rat influenc adiponectin signal skelet muscl brown white adipos tissu wat defin ucp express level male spragu dawley rat consum hfd fat week receiv daili intraperiton inject vehicl mgkg week mrna express gene involv metabol function measur skelet muscl adipos tissu blood harvest measur hormon cytokin muscl citrat synthas activ also measur treatment decreas fat pad weight epididym peri renal brown plasma level leptin glucagon ghrelin glp increas pai along rang pro inflammatori anti inflammatori cytokin howev alter plasma adiponectin level skelet muscl citrat synthas activ mrna express gene measur muscl treatment effect white fat ucp express level decreas fat pad mass alter plasma hormon level induc brown wat defin ucp mrna level alter gene express muscl treat acut adiponectin demonstr complex endocannabinoid system metabol cb ligand increas system inflamm suggest limit use metabol disord | D054439;D020738 | T116;T125 |
36,232,743 | selaginella tamariscina inhibit glutam induc autophag cell death activ pikaktmtor signal pathway glutam induc neural toxic autophag neuron death partial mediat increas oxid stress therefor reduc oxid stress brain critic treat prevent neurodegen diseas selaginella tamariscina tradit medicin plant treat gastrointestin bleed hematuria leucorrhea inflamm chronic hepat gout hyperuricemia investig inhibitori effect selaginella tamariscina ethanol extract ste neurotox autophag cell death glutam expos ht mous hippocamp cell ste signific increas cell viabil mitochondri membran potenti decreas express reactiv oxygen speci lactat dehydrogenas releas cell apoptosi glutam expos ht cell addit glutam induc excess activ mitophagi ste attenu glutam induc light chain lc ii beclin express increas p express furthermor ste strong enhanc phosphatidylinositol kinas pik protein kinas b akt mammalian target rapamycin mtor phosphoryl activ ste strong inhibit glutam induc autophagi activ pikaktmtor signal pathway contrast addit ly pikakt inhibitor remark suppress cell viabil p akt p express mark increas express lc ii beclin find indic autophagi inhibit activ pikaktmtor phosphoryl level could respons neuroprotect effect ste glutam neuron damag | D000080549;D018696;D032503 | T121;T169;T043;T002 |
36,232,742 | decreas express slca gene cytoplasm reloc membran ctr protein renal epitheli cell potent protect mechan copper nephrotox mous model menk diseas kidney play especi role copper redistribut organ epitheli cell proxim tubul perform function copper uptak primari urin releas blood cell equip apic basal membran copper transport ctr atpa mosaic mutant mice display function dysfunct atpa establish model menk diseas mice exhibit system copper defici despit renal copper overload enhanc copper therapi indispens life span extens aim studi analyz express slca slca gene encod ctrctr protein cellular local ctr protein suckl young adult mosaic mutant result indic kidney intact copper inject day old mutant show high renal copper content ctr mrna level regul compar wild type mice given copper inject express slca gene day old mice even reduc compar intact wild type anim suckl young copper inject mutant ctr protein reloc apic membran cytoplasm epitheli cell proxim tubul process prevent copper transport primari urin thus protect cell copper toxic | D003300;D000079923;D004847;D007687;D007706 | T023;T047;T116;T121;T123;T196;T025 |
36,232,741 | pancreat cancer cell induc microrna deregul platelet pancreat cancer patholog high mortal rate sinc detect advanc stage search earli stage diagnost biomark essenti liquid biopsi current explor purpos educ platelet good candid sinc known present bidirect interact tumor cell work analyz effect platelet cancer cell viabil determin mtt migrat use transwel assay clonogen soft agar stem dilut assay stem marker express found co cultur platelet pancreat cancer cell increas prolifer migrat capac bxcp cell augment clonogen induc higher level nanog sox oct express platelet provid horizont transfer microrna also determin differenti express mirna platelet obtain small cohort pancreat cancer patient healthi subject found clear differ express sever mirna platelet patient cancer healthi subject moreov analyz microrna platelet pancreat juic blood deriv cancer patient interest find differ blood pancreat juic deriv platelet suggest presenc differ subpopul platelet cancer patient warrant analysi | D035683;D010190 | T191;T123;T114 |
36,232,740 | ngf induc upregul cgrp orofaci pain induc tooth movement depend atpva vesicl releas nerv growth factor ngf calcitonin gene relat peptid cgrp play crucial role regul orofaci pain demonstr cgrp increas orofaci pain induc ngf v type proton atpas subunit isoform atpva involv exocytosi pathway especi vesicular transport neuron object examin role atpva ngf induc upregul cgrp orofaci pain induc experiment tooth movement orofaci pain elicit ligat close coil spring incisor molar spragu dawley rat gene protein express level determin real time polymeras chain reaction immunostain fluoresc situ hybrid lentivirus vector carri atpva shrna use knockdown express atpva tg sh syy neuron releas vesicl sh syy neuron observ use fluoresc dye fm releas cgrp detect enzym link immunosorb assi orofaci pain evalu rat grimac scale result reveal intraganglion administr ngf atpva shrna upregul downregul cgrp trigemin ganglia tg trigemin subnucleus caudali vc respect orofaci pain also exacerb allevi respect follow administr ngf atpva shrna besid intraganglion administr ngf simultan caus downregul atpva tg moreov releas vesicl cgrp sh syy neuron interf ngf atpva shrna conclus orofaci pain induc experiment tooth movement ngf induc upregul cgrp tg vc process depend atpva vesicl releas suggest involv transmiss nocicept inform orofaci pain | D015740;D005157;D020932;D014087;D025262 | T116;T061;T123;T126;T184;T125 |
36,232,739 | character trehalos phosphat synthas trehalos phosphat phosphatas gene tomato solanum lycopersicum l analysi differenti express respons temperatur plant trehalos biosynthet pathway play key role regul carbon alloc stress adapt engin pathway hold great promis increas stress resili crop plant synthesi trehalos proceed two step pathway trehalos phosphat synthas tps use udp glucos glucos phosphat produc trehalos phosphat tp subsequ dephosphoryl trehalos phosphat phosphatas tpp plant usual accumul high amount trehalos genom encod larg famili putat trehalos biosynthesi gene mani member lack obvious enzymat activ thus function putat trehalos biosynthet protein plant vagu understood gain deeper insight role trehalos biosynthet protein crop assess enzymat activ tpstpp famili tomato solanum lycopersicum l investig express pattern differ tissu well respons temperatur shift tps isoform test protein belong class show enzymat activ tpp isoform investig catalyt activ tpstpp famili member show highest express matur leav promot report gene studi suggest two class tps gene larg overlap express pattern within vasculatur subtl differ express fruit flower major tomato tpstpp gene induc heat stress individu famili member also respond cold suggest trehalos biosynthet pathway gene could play import role temperatur stress adapt summari studi repres step toward exploit tps tpp gene famili improv tomato stress resist | D018551 | T168;T002 |
36,232,738 | mir p mir p key actor age relat diseas microrna mirna small singl strand non code rnas power gene express regul main bind utr sequenc target mrna lead degrad translat inhibit mir gene encod pre mir generat two matur mirna mir p mir p mir p p associ develop progress cancer also non neoplast diseas age relat diseas mir p mir p express modul seric level two mirna use circul biomark may repres predict tool also consid key actor pathophysiolog age relat diseas mir p p repress target regul cell prolifer apoptosi senesc inflamm work focus role mir p mir p age relat diseas detail regul ie long non code rna review molecular target these mirna involv age pathophysiolog | D035683;D062085 | T123;T114 |
36,232,737 | wnt catenin signal pathway strong implic cadmium induc development neurotox neuroinflamm clue zebrafish neurobehavior vivo neuroimag cadmium cd toxic heavi metal worldwid environment pollut serious threaten human health ecosystem easi adsorb deposit organ exert advers effect various organ includ brain recent studi make full use zebrafish model high throughput behavior track live neuroimag explor potenti development neurotox cd environment relev level identifi multipl connect cd exposur neurodevelopment disord well microglia mediat neuroinflamm wherea under neurotox mechan remain unclear canon wnt catenin signal pathway play crucial role mani biolog process includ neurodevelop cell surviv cell cycl regul well microgli activ therebi potenti present one key target cd neurotox therefor follow studi investig implic wnt catenin signal pathway cd induc development disord neuroinflamm reveal environment cd exposur signific affect express key factor zebrafish wnt catenin signal pathway addit pharmacolog intervent pathway via tws increas protein level catenin act classic activ wnt signal pathway could signific repress cd induc cell cycl arrest apoptosi therebi attenu inhibitori effect cd earli develop behavior activ well neurodevelop zebrafish larva certain degre furthermor activ prolifer microglia well alter express profil gene associ neuroimmun homeostasi trigger cd exposur could also signific allevi activ wnt catenin signal pathway thus studi provid novel insight cellular molecular mechan cd toxic vertebr central nervous system cns might help develop pharmacotherapi mitig neurolog disord result exposur cd mani environment heavi metal | D002104;D004785;D000090862;D020258;D060449 | T047;T037;T131;T196;T044;T033 |
36,232,736 | wnt induc signal pathway protein stroma specif secret protein induc fibroblast contract carcinoma cell growth human prostat wnt induc signal pathway protein wisp member connect tissu growth factor famili play crucial role sever import cellular function high tissu specif manner result rt qpcr indic wisp express cell human prostat fibroblast hprf wpmi prostat carcinoma cell vitro two major isoform wispv wispv identifi hprf cell determin rt pcr immunoblot assay knock wisp block cell prolifer contract treat respect condit medium ectop wispv wispv overexpress cell enhanc migrat hprf cell tnf induc wisp secret cell contract knock wisp attenu effect although tnf affect prolifer hprf cell ectop overexpress wispv wispv downregul n myc downstream regul ndrg upregul n cadherin slug snail vimentin gene express induc cell prolifer invas vitro also tumor growth prostat carcinoma cell vivo result confirm wisp stroma specif secret protein enhanc cell migrat contract prostat fibroblast well prolifer invas tumor growth prostat carcinoma cell | D055511;D002471;D005347;D011471;D011518 | T191;T025;T123;T116 |
36,232,735 | antivir peptid anti influenza agent influenza virus repres lead caus high morbid mortal worldwid approach fight flu season vaccin antivir drug develop season flu vaccin requir great deal effort care studi need select strain includ year vaccin antivir drug avail influenza virus infect certain limit due increas resist rate negat side effect high mutat natur virus lead emerg new antigen variant urgent develop new approach antivir therapi need among approach one emerg new field peptid base therapi influenza virus explor look promis review describ recent find antivir activ mechan action therapeut capabl antivir peptid bind ha na pb mean counter influenza virus infect | D007252;D007251;D009975;D009976 | T047;T121;T109;T129;T005 |
36,232,734 | novel beta glucosidas gene plant type identifi genom wide associ studi gene co express analysi widespread bermudagrass bermudagrass cynodon spp one wide distribut warm season grass global growth habit plant type bermudagrass strong associ appli purpos landscap livestock eco remedi therefor persist effort made investig genet basi plant type growth habit bermudagrass dissect genet divers wild bermudagrass resourc genom wide associ studi gwas combin weight gene co express analysi wgcna work base rna seq data genom african bermudagrass cynodon transvaalensi burtt davi sixteen reliabl singl nucleotid polymorph snps transcrib region identifi associ plant height iaa content divers bermudagrass gwas integr result wgcna indic beta glucosidas cdbglu candid gene under ga snp signal furthermor qrt pcr correl coeffici analys indic cdbglu might play comprehens role plant height iaa biosynthesi signal addit observ lower plant height arabidopsi bglu mutant homolog cdbglu uncov breed select histori differ plant type divers bermudagrass provid new insight molecular function cdbglu plant type iaa biosynthet pathway | D017360;D031744 | T002 |
36,232,733 | cd cell phenotyp function childhood adult onset connect tissu diseas cd cell cytotox lymphocyt destroy pathogen infect malign cell releas cytolyt molecul proinflammatori cytokin although role cd cell connect tissu diseas ctds explor thorough immun cell research focus key compon immun system recent gain momentum aberr cytotox cell function may implic trigger autoimmun may promot tissu damag lead exacerb diseas comprehens review current literatur examin role cd cell system lupus erythematosus sjgren syndrom system sclerosi polymyos dermatomyos specif focus compar known cd cell peripher blood phenotyp cd cell function cd cell organ specif profil adult juvenil form disord although precis role cd cell initi autoimmun diseas progress remain elucid increas evid indic cd cell emerg attract target therapi ctds | D003240;D008180;D017285;D012595;D012859 | T047 |
36,232,732 | relev soft tissu sarcoma metabol landscap map soft tissu sarcoma sts prognosi disappoint current treatment strategi base fit principl take distinct sarcoma subtyp specif geneticmetabol differ consider pauciti precis therapi sts reflect shortag studi seek deciph sarcomagenesi mechan urg improv sts diagnosi precis refin sts classif criteria increas capabl identifi sts prognost biomark singl omic multi omic studi may play key role decodifi sarcomagenesi metabolom provid singular insight either singl omic approach part multi omic strategi metabol adapt support sarcomagenesi although sts metabolom scarc character untarget target metabolom approach employ differ data acquisit method mass spectrometri ms ms imag nuclear magnet reson nmr spectroscopi provid import inform warrant studi new chromatograph ms nmr base flow cytometri base method offer opportun therapeut target metabol pathway monitor respons metabol target therapi provid comprehens review sts omic applic compris detail analysi studi focus metabol landscap tumor | D012509;D012983 | T191 |
36,232,731 | theoret studi exciton bind energi exciton absorpt differ hyperbol type quantum well appli electr magnet intens laser field studi investig exciton bind energi interband transit electron heavi hole singl doubl quantum well differ hyperbol type potenti function subject electr magnet non reson intens laser field result obtain show geometr shape structur appli extern field effect electron optic properti absenc extern field exciton bind energi decreas function increas well size except strong confin regim therefor appli extern field increas well width produc red shift absorpt peak posit magnet field caus increas exciton bind energi provid blue shift absorpt peak posit correspond interband transit effect electr field quit pronounc weak confin regim caus local opposit direct quantum well electron hole therebi weaken coulomb interact caus decreas exciton bind energi red shift peak posit correspond interband transit general intens laser field caus decreas exciton bind energi produc red shift peak posit correspond interband transit | D008962;D011789 | T062;T170 |
36,232,730 | triclosan consequ reproduct cardiovascular thyroid level hygien essenti avoid diseas thank daili clean disinfect habit current numer commerci product contain antimicrobi agent although effici disinfect still known effect constant use product human health fact massiv use disinfect observ due covid possibl advers effect yet known triclosan one antimicrobi agent use cosmet product toothpast disinfect compound endocrin disruptor mean interfer hormon function estrogen androgen activ alreadi state even use triclosan well regul maximum allow concentr european union effect human health still uncertain studi anim human suggest possibl harm health outcom particular reproduct system less extent cardiovascular thyroid function thus purpos review analys possibl implic massiv use triclosan main reproduct cardiovascular system thyroid function anim human | D000891;D000086382;D002319;D004202;D052244;D014260 | T022;T047;T167;T131;T121;T109;T067;T039 |
36,232,729 | uniqu structur fold lonba proteas bacillus subtili member newli identifi subfamili lon proteas atp depend lon proteas key particip qualiti control system support homeostasi cellular proteom base uniqu structur biochem properti lon proteas assign merop databas three subfamili b c lon singl chain multidomain protein contain atpas proteas domain differ addit element present subfamili lona lonc proteas solubl cytoplasm enzym wherea lonb membran bound base analysi avail sequenc lon proteas identifi number enzym current assign lonb subfamili although presum membran bound includ structur featur similar counterpart lona subfamili observ confirm crystal structur proteolyt domain enzym previous assign bacillus subtili lonb combin model structur atpas domain sever structur featur present domain differ counterpart either lona lonb subfamili thus postul enzym found member newli identifi lonba subfamili far found gene sequenc firmicut | D049070 | T126;T116 |
36,232,728 | vitro model studi chronic drug induc liver injuri drug induc liver injuri dili major clinic problem term patient morbid mortal cost healthcar system failur develop new drug need consist safeti strategi capabl identifi potenti toxic risk earli drug discoveri pipelin key human dili poor predict anim probabl due well known interspeci differ drug metabol pharmacokinet toxic target reason distinct cellular model primari human hepatocyt hepatoma cell line cultur monolay emerg cultur system use multi cellular system propos hepatotox studi order mimic long term hepatotox vitro cell model maintain hepat phenotyp suitabl long period use hand repeat dose administr relev scenario therapeut provid inform toxic also cumul effect andor delay respons review evalu exist cell model dili predict focus chronic hepatotox highlight better character mechanist studi could lead advanc dili predict | D056486;D056487;D064420 | T047;T046;T037 |
36,232,727 | develop transform system locus identif pipelin dna chrysanthemum seticusp model speci hexaploid cultiv chrysanthemum chrysanthemum one popular flower worldwid high aesthet commerci valu howev cultiv varieti chrysanthemum hexaploid high heterozyg make gene edit gene function research difficult gojo diploid homozyg line bred self compat mutant chrysanthemum seticusp expect becom model plant genus chrysanthemum assess differ growth regul combin optim concentr naphthaleneacet acid naa benzyladenin ba regener system mgl mgl respect genet transform system select concentr kanamycin hygromycin glufosin ammonium mgl mgl mgl bud generat mg l mgl mgl root transgen plant verifi pcr detect gus stain also identif dna insert locus use high throughput sequenc result lay foundat gene function research chrysanthemum help identif transgen plant | D031202 | T002 |
36,232,726 | mucopolysaccharidosi plus syndrom report polish patient novel vpsa variant comparison describ patient eleven patient yakutia new lysosom diseas assum mucopolysaccharidosi plus syndrom mps ps report gurinova et al total number patient report cc gt pargtrp variant vpsa gene detect describ first polish mps ps patient novel homozyg cg gt c pargpro vpsa variant present year follow novel clinic featur includ fetal ascit resolv spontan recurr joint effus peripher edema normal growth viscer obes function analys reveal slight presenc chondroitin sulphat urin glycosaminoglycan electrophoresi presenc sialooligosaccharid urin thin layer chromatographi normal result lysosom enzym activ lysosphingolipid concentr dri blood spot comparison mps ps describ case also provid present descript natur histori mps ps patient may broaden spectrum phenotyp diseas | D009083;D033921 | T047;T123;T116 |
36,232,725 | postsynapt protein excitatori synaps brain relationship depress disord depress disord dds increas common health problem affect age group dds pathogenesi multifactori howev proven stress one import environment factor contribut develop condit recent year grow interest role glutamaterg system context pharmacotherapi dds thus becom increas import explor function excitatori synaps pathogenesi pharmacolog treatment psychiatr disord includ dds knowledg may lead descript new mechan depress indic new potenti target pharmacotherapi ill excitatori synaps high complex dynam structur contain vast number protein review aim discuss detail role key postsynapt protein eg nmdar ampar mglur psd homer nos etc excitatori synaps systemat knowledg chang occur clinic cours depress antidepress treatment addit discuss potenti use ligand andor modul postsynapt protein excitatori synaps present | D003866;D013569 | T030;T048 |
36,232,724 | function plasmon activ water increas akkermansia muciniphila abund gut microbiota amelior inflammatori bowel diseas inflammatori bowel diseas ibd associ dysbiosi intestin barrier dysfunct indic epitheli hyperperm high level mucos associ bacteria chang gut microbiota may correl ibd pathogenesi addit microb base treatment could mitig clinic ibd symptom plasmon activ water paw known anti inflammatori potenti work studi associ anti inflammatori abil paw intestin microb therebi improv ibd treatment examin paw induc chang colon immun activ microbiota mice immunohistochemistri next generat sequenc determin whether drink paw mitig ibd induc trinitrobenzen sulfon acid tnbs dysbiosi mice anim model effect specif probiot speci mice tnbs induc ibd also investig experiment result indic paw could chang local inflamm intestin microenviron moreov abund akkermansia spp degrad tnbs treat mice elev paw drink mice daili rectal inject akkermansia muciniphila potenti probiot speci akkermansia spp also improv health mice correspond paw consumpt increas intestin abund akkermansia muciniphila mitig ibd mice find indic increas abund akkermansia muciniphila gut paw consumpt method may mitig ibd mice clinic signific ibd | D000069196;D015212 | T007;T001;T047 |
36,232,723 | deciph basi molecular biolog select cardiovascular diseas view network medicin cardiovascular diseas lead caus death across world decad research studi caus cardiovascular diseas yet mani remain undiscov poor understood network medicin recent expand integr field attempt elucid issu conceiv diseas result disrupt link multipl interconnect biolog compon still nascent stage revolutionari applic network scienc facilit number import discoveri complex diseas mechan methodolog becom advanc network medicin harbor potenti expound molecular genet complex diseas differenti intricaci govern diseas manifest prognosi therapi paramount import confront incred challeng current futur cardiovascular diseas research review summar princip molecular genet mechan common cardiac pathophysiolog well discuss exist knowledg therapeut strategi prevent halt revers patholog | D002318;D006331;D008511 | T047;T091 |
36,232,722 | identif gene metabol pathway involv resin yield masson pine integr analysi transcriptom proteom biochem characterist masson pine pinus massoniana l one import resin produc tree speci southern china howev molecular regulatori mechan resin yield still unclear masson pine studi integr analysi transcriptom proteom biochem characterist needl masson pine high common resin yield investig result show chlorophyl chl chlorophyl b chl b total chlorophyl chl c carotenoid car glucos glu gibberellin ga gibberellin ga gibberellin ga signific increas wherea fructos fru jasmon acid ja jasmonoyl l isoleucin ja ile gibberellin ga gibberellin ga gibberellin ga gibberellin ga signific decreas high resin yield comparison common one integr analysi transcriptom proteom show chlorophyl synthas chlg hexokinas hxk sucros synthas sus phosphoglycer kinas pgk dihydrolipoamid dehydrogenas pdh dihydrolipoamid succinyltransferas dlst oxophytodieno acid reductas opr jasmon methyltransferas jmt consist transcriptom proteom biochem level pathway carbohydr metabol terpenoid biosynthesi photosynthesi hormon biosynthesi may play crucial role regul resin yield key gene involv pathway may candid influenc resin yield result provid insight molecular regulatori mechan resin yield also provid candid gene appli molecular assist select breed high resin yield masson pine | D005875;D028223 | T109;T123;T002 |
36,232,721 | vascular liver homeostasi juvenil mice requir endotheli cyclic amp depend protein kinas vascular develop endotheli camp depend protein kinas pka regul angiogenesi control number tip cell pka inhibit lead excess angiogenesi whether role endotheli pka restrict embryon neonat develop also requir vascular homeostasi later unknown show perinat postnat day p p later p p inhibit endotheli pka use domin negat pka express control endotheli specif cdh creert recombinas dnpka iec mice lead sever subcutan edema hypoalbuminemia hypoglycemia prematur death chang accompani local hypersprout blood vessel fat pad secondari enlarg subcutan lymphat vessel notic endotheli pka inhibit caus dramat disorgan liver vasculatur hepat chang correl decreas gluconeogenesi liver albumin product seem unaffect hypoalbuminemia rather result increas leakag interstitium interest express dnpka lymphat use prox creert produc phenotyp likewis mosaic express endotheli subpopul use vegfr creert insuffici induc edema hypoglycemia increas express tip cell marker esm indic inhibit pka induc angiogen respons liver although tissu deriv pro anti angiogen factor unchang data indic endotheli pka gatekeep endotheli cell activ develop also adult homeostasi prevent aberr reactiv angiogen program | D001808;D054751;D042783;D008099 | T023;T025;T126;T116 |
36,232,720 | migrain pharmacolog treatment cognit impair risk benefit migrain common neurolog disord impair qualiti life patient condit requir acut prophylact line intervent frequent use drug act central nervous system cns long term impact medic cognit neurodegener never consist assess paper review pharmacolog migrain treatment discuss biolog clinic effect cns differ anti migrain drug show distinct profil concern neurodegener risk cognit deficit featur care evalu prescrib pharmacolog treatment mani migraineur scholar work age perform may affect drug misus thus reconsider therapi guidelin warrant furthermor sinc conflict result emerg relationship migrain dementia futur studi must consid present past pharmacolog regimen potenti confound factor | D003072;D060825;D008881 | T047;T048 |
36,232,719 | chemoresist relat stem cell signal osteosarcoma plausibl contribut poor therapeut respons discuss still matter osteosarcoma amongst preval bone sarcoma major afflict children adolesc therapeut regimen base triad doxorubicin cisplatin methotrex use state art approach clinic treatment manag signific improv general outcom sinc incept earli fact rais follow problemat question patient still relaps despit initi good respons therapi near patient respond neoadjuv therapi residu persist diseas contribut relaps possibl metastat dissemin accumul evid suggest chemoresist cancer stem cell may major culprit contribut challeng clinic outcom herein revisit maneuv cancer stem cell devis elud cell kill classic cytotox therapi use osteosarcoma highlight studi demonstr complex crosstalk signal pathway cancer stem cell recruit becom chemoresist | D001859;D012516 | T191 |
36,232,718 | cold induc nuclear import cbf regul freez toler c repeat bind factor cbfs crucial transcript activ plant respons low temperatur cbf differ slower persist regul role cold acclim cold acclim accentu relev toler late spring frost becom progress common consequ blur season context global climat chang current studi explor function cbf grapevin vvcbf overexpress vvcbf fuse gfp tobacco cell confer cold toler furthermor protein shuttl cytoplasm nucleus respons cold stress associ accumul transcript cbfs cold respons gene erdd respons differ chill compar freez regul differ upstream signal involv oxid burst proteasom activ jasmon synthesi differ chill freez also seen regul cbf transcript leav differ grapevin differ cold toler therefor propos qualiti cold stress transduc differ upstream signal regul nuclear import thus transcript activ grapevin cbf | D018506;D046988 | T045;T126;T116 |
36,232,717 | molecular research lipid peroxid antioxid enzym activ comamona testosteroni bacteri cell hexachlorobenzen impact speci comamona testosteroni common human pathogen genus associ acut append infect bloodstream periton caviti cerebrospin fluid inflammatori bowel diseas general bacteremia accord literatur comamona testosteroni destruct activ wide rang toxic chemic compound includ chlorobenzen specifi strain isol soil organochlorin wast landfil hexachlorobenzen hcb predomin strain expect capabl degrad hcb microbiolog bacteri enrich cultiv bacteri biomass obtain molecular biolog biochem enzymat activ malondialdehyd measur peroxid lipid product measur statist method carri research reaction strain ucm b ucm b hexachlorobenzen presenc differ content dien trien conjug malondialdehyd well differ catalas peroxidas activ level term primari peroxid product dien conjug lower except condit mgl hcb higher two time pure control malondialdehyd strain b cell decreas five time b increas two time compar pure control schiff base strain b cell time lower pure control howev b cell schiff base higher hcb dose level pure control catalas activ time higher experiment variant compar pure control strain b cell b strain cell time lower compar pure control respons two strain hexachlorobenzen similar peroxidas activ term slight higher compar pure control physiolog respons comamona testosteroni strain hexachlorobenzen typic strain reaction physiolog respons level strain hexachlorobenzen confirm toler indirect abil destroy specifi toxic compound | D020604;D006581 | T007;T109;T131 |
36,232,716 | oxid stress mitochondri complex dysfunct correl neurodegener synucleinopathi anim model synucleinopathi constitut subset neurodegen disord parkinson diseas pd common worldwid character accumul misfold synuclein cytoplasm neuron spread prion like manner anatom interconnect brain area howev clear synucleinopathi trigger neurodegener recent develop rat model singl intranigr administr neurotox sitosterol glucosid bssg produc synucleinopathi model aim evalu tempor pattern level oxid nitros stress mitochondri complex ci dysfunct biochem paramet associ neurodegener differ brain area synucleinopathi substantia nigra par compacta striatum hippocampus olfactori bulb syn aggreg spread interest increas oxid stress mitochondri ci dysfunct accompani neurodegener brain region furthermor silico analysi suggest high affin bind site bssg peroxisom prolifer activ receptor ppar alpha ppar gamma ppar find contribut elucid pathophysiolog mechan associ synucleinopathi lead identif new earli biomark therapeut target | D001921;D042967;D008928;D018384;D000080874;D051844 | T023;T047;T116;T026;T049;T126;T123;T043 |
36,232,715 | pauf induc migrat human pancreat cancer cell exclus via tlrmydnf b signal pathway pauf tumor promot protein secret cancer cell exert paracrin effect immun cell tlr receptor express immun cell surfac studi aim investig pauf elicit autocrin effect pancreat cancer pc cell tlr receptor overexpress pc cell studi tlr express detect pc cell normal pancreat cell migrat tlr high express pc cell ie bxpc reduc select tlr inhibitor dose depend manner use tlr overexpress knockout pc cell line observ direct pauf tlr bind pc cell surfac pauf induc cancer migrat may mediat exclus tlr receptor experi show pauf signal pass tlrmyd pathway without involv tlrtrif pathway tlr knockout also downregul pc membran pd l express influenc pauf best knowledg tlr first receptor identifi cancer cell mediat pauf migrat promot effect result studi enhanc understand mechan pauf induc tumor promot effect suggest tlr express cancer cell may import biomark anti pauf treatment | D036341;D053594;D052002;D010190;D051197 | T116;T192;T191;T123;T129 |
36,232,714 | runxcebpa mutat acut myeloid leukemia promot hypermethyl indic demethyl therapi acut myeloid leukemia aml rapid progress heterogen diseas high mortal rate character hyperprolifer atyp immatur myeloid cell number aml patient expect increas near futur due old age associ natur aml increas longev human popul runx cebpa key transcript factor tfs hematopoiesi frequent independ mutat aml runx cebpa bind tet demethylas attract bind site tfbs cell line lead dna demethyl region nearbi sinc tet dna bind domain tfs crucial guidanc target genom locat paper show runx cebpa mutat aml patient affect methyl import regulatori site result silenc sever runx cebpa target gene like tet depend manner demonstr hypermethyl tfbs aml cell runx mutat associ resist anticanc chemotherapi demethyl therapi restor express runx target gene bik increas sensit aml cell chemotherapi result confirm mutat runx could indic prescrib combin cytotox demethyl therapi | D022762;D050676;D015470 | T191;T123;T116 |
36,232,713 | betain base deep eutect solvent new media laccas catalyz templat guid polymerizationcopolymer anilin aminobenzo acid deep eutect solvent dess compens major drawback tradit organ solvent ionic liquid meet requir green chemistri howev potenti use medium biocatalyt reaction adequ studi work use des betain glycerol molar ratio co solvent enzymat templat guid polymerizationcopolymer anilin ani aminobenzo acid aba laccas basidi fungus tramet hirsuta air oxygen serv catalyst oxid respect sodium polystyren sulfon pss use templat interpolyelectrolyt complex homopolym polyanilin pani poli aminobenzo acid paba copolym poli anilin co aminobenzo acid p ani aba prepar physico chemic properti studi uv vis ftir spectroscopi cyclic voltammetri accord result obtain atom forc microscopi panipss granular shape p ani aba pss spheric shape pabapss spindl like shape copolym show greater antimicrobi activ escherichia coli staphylcocus aureus compar homopolym minim inhibitori concentr p ani aba pss gram posit bacterium aureus mg ml | D000890;D052578 | T121;T103;T120 |
36,232,712 | femal germ cell develop chicken human chicken oocyt enrich gene converg diverg human oocyt develop germ cell physiolog event differenti ovari human high conserv sever mammalian speci except differ time howev compar knowledg topic scarc respect human lower vertebr chicken chicken femal germ cell enter meiosi around embryon day e arrest meiotic prophas primari oocyt oocyt arrest meiosi accumul germ cell cyst short hatch enclos flatten granulosa cell order form primordi follicl human process meiotic recombin femal germ cell begin th week gestat primordi follicl form around week review comprehens elucid conserv speci specif differ chicken human respect germ cell oocyt follicl develop import provid function insight set chicken oocyt enrich gene e week post hatch show converg diverg express pattern respect human oocyt week | D002645;D008540 | T012;T043 |
36,232,711 | autophagi lifetim plant seed seed autophagi high conserv self degrad mechan eukaryot excess harm intracellular content encapsul doubl membran autophag vacuol transfer vacuol degrad plant current research show three type autophagi plant macroautophagi import autophag degrad pathway autophagi relat atg protein identifi plant involv macroautophagi protein play import role plant growth regul stress respons review main introduc research progress autophagi plant veget growth root leav reproduct growth pollen resist biotic virus bacteria fungi abiot stress nutrient drought salt cold heat stress discuss applic direct plant autophagi futur | D001343;D010944 | T043;T002 |
36,232,710 | comparison homolog heterolog booster sar cov vaccin autoimmun rheumat musculoskelet patient vaccin sar cov prevent covid high recommend immunocompromis patient autoimmun rheumat musculoskelet diseas airmd littl known effect booster vaccin infect follow previous complet two dose vaccin airmd determin neutral anti sar cov antibodi level appli flow cytometr immunophenotyp quantifi sar cov reactiv b cell mediat immun airmd receiv homolog heterolog booster acquir infect follow vaccin patient receiv heterolog booster higher proport igm sar cov cdcd peripher memori b cell comparison acquir infect biolog therapi decreas number scd scdcdigg scdcdigm b cell respons rate booster event cellular immun highest n reactiv cdcdl cell subset patient diseas durat year higher proport cdtnf cdifn cell comparison patient diagnos less year ago detect neutral antibodi reactiv peripher memori b cell five n reactiv cell subset patient cohort show import booster event biolog therapi lt year diseas durat may confound anti sar cov specif immun airmd | D000086382;D000086402 | T047;T067;T005 |
36,232,709 | high perform comput pp distanc algorithm generat x ray spectra model x ray crystallographi power method signific contribut understand biolog function protein molecul method reli product crystal howev usual bottleneck process molecul crystal achiev insuffici crystal obtain system crystal nanoparticl dimens treat usual crystallograph method solv whole pair distribut function propos bridg gap bragg deby scatter theori execut fit spectra sever differ construct compos million particl comput use particl pair particl particl pp distanc algorithm use comput test bench current field programm gate array fpga technolog evalu parallel comput capabl fpgas exploit reduc comput time present two differ solut problem use two state art fpga technolog first one main c program use ompss high level program model develop barcelona supercomput center enabl task offload differ high perform comput devic task invoc kernel built opencl use reduc data size save transmiss time second approach use task data parallel oper data local updat data global decoupl task benchmark evalu intel programm acceler card comput model million particl billion atom pair per second bapp zu last test date alveo u board comput last bapp studi analyz result relat classic term speed effici give hint futur improv focus reduc global job time | D000465 | T170 |
36,232,708 | synthesi ag po se ag ta nanoparticl antibacteri cytotox studi silver phosphat ag po high capabl clinic molecul ultrason method employ synthes ag po se ag ta nanoparticl evalu antibacteri cytotox activ post character escherichia coli staphylococcus aureus use antibacteri test effect sonic bacteri growth sub mic valu ag po nanoparticl examin effect ag po nanoparticl human colorect carcinoma cell hct human cervic carcinoma cell hela cell examin mtt dimethylthiazol yl diphenyl h tetrazolium bromid assay dapi diamidino phenylindol stain addit analyz effect nanoparticl normal non cancer human embryon kidney cell hek ag ag po exhibit enhanc antibacteri activ follow ta ag po ag po se ag po nanoparticl e coli wherea order antibacteri activ staphylococcus aureus ag po gt ag ag po gt ta ag po gt se ag po respect percentag inhibit e coli percentag inhibit aureus treatment ag po se ag po ag ag po ta ag po respect mtt assay show signific declin cell viabil treat ag po nanoparticl ic valu ag po se ag po ag ag po ta ag po hct gml wherea hela cell gml respect ag po nanoparticl inhibit hek cell apoptot assay reveal number dapi stain cell signific lower ag po treat cell versus control | D053768;D053758 | T073 |
36,232,707 | hepatoprotect effect natur flavanol diindolylmethan ccl induc chronic liver injuri mice tgf induc emt mous hepatocyt via activ nrf cascad hepat fibrosi form irregular wound heal respons acut chronic injuri trigger deposit excess extracellular matrix epitheli mesenchym transit emt dynam process play crucial role fibrogen respons pathogenesi liver fibrosi present studi postul protect role diindolylmethan dim tgf mediat epitheli mesenchym transit emt vitro carbon tetrachlorid ccl induc liver fibrosi mice tgf induc aml hepatocyt injuri evalu monitor cell morpholog measur reactiv oxygen speci ros mitochondri membran potenti quantifi apoptosi inflammatori emt relat protein furthermor ccl induc liver fibrosi mice evalu perform liver function test includ serum alt ast total bilirubin albumin assess liver injuri perform h e sirius red stain determin degre liver fibrosi immunoblot perform determin express level inflamm apoptosi nrfho signal relat protein dim treatment signific restor tgf induc morpholog chang inhibit express mesenchym marker activ e cadherin decreas mitochondri membran potenti reduc ros intens upregul level nrf respons antioxid gene mous model ccl induc liver fibrosi dim remark attenu liver injuri liver fibrosi reflect reduc alt ast paramet increas serum alb activ fewer lesion h e stain also mitig fibrosi area sirius red masson stain taken togeth result suggest possibl molecular mechan dim suppress tgf induc emt mous hepatocyt ccl induc liver fibrosi mice | D002251;D053773 | T116;T131;T121;T109;T123 |
36,232,706 | karyotyp analysi genom fluoresc situ hybrid gish fish reveal ploidi parent origin chromosom paeonia itoh hybrid itoh hybrid intersect hybrid paeonia l sect moutan sect paeonia patern matern parent respect therefor hybrid herbac stem improv ornament valu introduc patern parent although parent diploid itoh hybrid triploid moreov parent origin chromosom extens studi studi systemat analyz genom size ploidi karyotyp itoh hybrid compar parent taxa although monoploid genom size itoh hybrid differ signific differ parent howev size varieti two parent taxa signific differ wild speci probabl due genom rearrang caus artifici select karyotyp analysi correl analysi hierarch cluster could identifi parent origin chromosom itoh hybrid verif genom fluoresc situ hybrid gish fish suggest three set chromosom itoh hybrid two patern parent one matern parent one first two set wild speci cultiv varieti gish could label chromosom cultiv peoni sect moutan probabl due huge complex genom compar wild speci meanwhil rdna base fish first appli paeonia may use ploidi assess work may give insight util itoh hybrid resourc | D029596 | T002 |
36,232,705 | three way dna junction end label dna atom forc microscopi studi atom forc microscopi afm wide use topograph imag dna protein dna complex ambient condit nanomet resolut afm studi protein dna complex identifi protein locat dna substrat one major goal studi requir distinguish dna end accomplish end specif label dna substrat select label three way dna junction wj assembl synthet dna oligonucleotid two arm bp third arm three nucleotid overhang gct pair sticki end dna substrat generat sapi enzym ligat wj result format type structur end linear dna mole cule routin identifi afm imag yield label relat orient arm end vari dynam direct visual time laps afm studi use high speed afm hs afm label approach appli character nucleosom array assembl differ dna templat hs afm experi reveal high dynam nucleosom result spontan unravel follow disassembl nucleosom | D004247;D009707 | T123;T116;T114 |
36,232,704 | pd l potenti immunomodul link immunolog orthodont induc inflammatori root resorpt oiirr friend foe orthodont induc inflammatori root resorpt oiirr consid undesir inevit complic induc orthodont forc inflammatori mechan regul immun cell preced orthodont tooth movement otm influenc sever oiirr process oiirr base immun respons occas immun system attack dentit inflammatori process orthodont treatment studi involv pd pd l immun checkpoint demonstr role evad immun respons aim identifi possibl novel therapeut approach periodont field orthodont import question aris whether pd l role develop oiirr amplifi amount resorpt hypothes block pd l immun checkpoint could suitabl procedur reduc process oiirr orthodont tooth movement review attempt shed light regul immun mechan inflammatori respons could influenc pathogenesi oiirr acquir knowledg role pd l immunomodul involv oiirr possibl clinic outcom discuss relat pd l express immunolog chang throughout resorpt process | D060890;D012391;D014087 | T061;T047;T116;T129 |
36,232,703 | associ grain yield agronom trait gene plant height photoperiod sensit plastid glutamin synthetas winter bread wheat triticum aestivum l collect reduct plant height caus mutat rht b rht reduc height gene combin day length independ earli flower associ ppd photoperiod gene main factor drastic yield increas bread wheat increas nitrogen use effici well maintain high yield condit global climat chang modern goal wheat breed glutamin synthetas gs enzym play key role ammonium assimil plant previous studi tag gene code plastid isoform gs shown connect nitrogen use effici wheat use polymeras chain reaction pcr marker associ yield agronom trait haplotyp rht b rht ppd tag gene studi divers collect winter bread wheat cultivar grown krasnodar russia three year experi semidwarf photoperiod insensit confirm high favor grain yield tag ab haplotyp tendenc increas grain yield lodg resist main plant possess green revolut allel thus tag ab may potenti breed wheat cultivar altern dwarf gene tall cultivar may optim grow certain environ | D064751;D014908 | T002;T104;T168;T197 |
36,232,702 | tune function ionic liquid co captur increas concentr co atmospher relat global climat chang carbon captur util storag ccus import technolog reduc co emiss deal global climat chang develop new materi technolog effici co captur receiv increas attent among global research ionic liquid il especi function il uniqu properti almost vapor pressur thermal chemic stabil non flammabl tunabl properti use ccus great interest paper focus develop function il co captur past decad function il task specif il il activ site cation orand anion main content includ three part cation function il anion function il cation anion dual function il co captur addit classif structur synthesi function il also summar final futur direct concern prospect function il ccus discuss review benefici research obtain overal understand co philic il work open door develop novel il base solvent materi captur separ gase h nox nh | D052578 | T103;T120 |
36,232,701 | sp nfi regul express pnpt gene encod mitochondri protein involv cancer polyribonucleotid nucleotidyltransferas gene pnpt encod polynucleotid phosphorylas pnpase exoribonucleas involv mitochondri rna degrad surveil rna import mitochondrion character pnpt promot silico analysi luciferas report assay electrophoret mobil shift assay emsa chromatin immunoprecipit chip sirna base mrna silenc rt qpcr show specif protein sp transcript factor nuclear transcript factor nfi bind pnpt promot relev role regul promot activ pnpt express mitochondri activ also found kaplan meier surviv curv high express either pnpase sp nfi subunit nfya associ poor prognosi liver cancer summari result show relev sp nfi pnpt express point spnfi pnpase possibl target anti cancer therapi | D023081;D005095;D008113;D024101;D011117;D016329 | T126;T123;T116;T191 |
36,232,700 | effect nickel ion physiolog transcript respons carbon nitrogen metabol tomato root low nitrogen level nickel ni essenti trace element plant growth compon plant bodi mani differ function plant although confirm nickel ion ni havea certain regulatori effect nitrogen n metabol enough data prove whether exogen ni increas carbon c n metabol root tomato seedlingsund low nitrogen ln condit therefor present experi reveal key mechan ni mediat tomato root toler ln level tomato plant cultur two differ n level mmol l two differ ni level mg l niso h hydropon condit nine day collect root physiolog biochem transcriptom sequenc analys found activ n assimil relat enzym decreas ln level contrast ni signific increas activ n assimil relat enzym increas content nitrat ammonium nh total amino acid root transcriptom analysi differenti express gene deg identifi deg relat c n metabol downregul ln applic howev ni treatment pk pdhb gapdh nr nir gs gogat deg relat c n metabol signific upregul conclus result suggest ni regul c n metabol pathway tomato root allevi impact ln level | D064751;D018551;D014131 | T002;T121;T123;T168;T197;T196;T104 |
36,232,699 | insight gain rna edit target crispr cas famili cluster regular interspac short palindrom repeat crispr crispr associ protein cas system especi type ii cas system wide develop dna target form set matur precis gene edit system howev basic research applic crispr cas system rna still earli stage recent discoveri crispr cas type vi system provid possibl expans rna target technolog broad applic prospect type vi cas effector dinucleas activ catalyz pre crrna matur crrna produc strong rna cleavag activ cas specif recogn target rna fragment activ cascrrna complex collater cleavag activ date casx protein smallest effector cas famili amino acid promis platform rna target due lack protospac flank sequenc pfs restrict eas packag absenc perman damag studi highlight latest progress rna edit target crispr cas famili discuss applic cas basic research nucleic acid diagnosi nucleic acid track genet diseas treatment furthermor clarifi structur cas protein famili molecular mechan propos futur vision rna edit target crispr cas famili | D064130;D009696 | T123;T116;T114 |
36,232,698 | plasmacytoid dendrit cell novel cell base cancer immunotherapi plasmacytoid dendrit cell pdcs multifacet immun cell wide rang innat adapt immunolog function constitut first line defenc multipl viral infect also report activ particip antitumor immun respons clinic implic presenc pdcs tumor microenviron tme still ambigu clear pdcs possess abil modul tumor specif cell respons direct cytotox function therapeut strategi design exploit qualiti pdcs boost tumor specif immun respons could repres attract altern compar convent therapeut approach futur promis antitumor effect alreadi report phase iii clinic trial review mani role pdcs cancer present current advanc develop pdc base immunotherapeut approach treat cancer | D003713;D009369 | T191;T025 |
36,232,697 | modul combin improv vitro microrheolog properti airway surfac liquid cystic fibrosi airway epithelia cystic fibrosi cf genet diseas caus mutat cystic fibrosi transmembran conduct regul cftr protein plasma membran protein express apic surfac secretori epithelia airway airway defect absent function cftr protein determin abnorm chlorid bicarbon secret general transepitheli homeostasi lead alter airway surfac liquid asl composit properti reduct asl volum impair ciliari beat consequ accumul sticki mucus situat prevent normal mucociliari clearanc favor surviv prolifer bacteria contribut genesi cf pulmonari diseas explor potenti cftr modul name ivacaftor tezacaftor elexacaftor combin kaftrio tm capabl partial recov basic defect cftr protein amelior transepitheli fluid transport viscoelast properti mucus use singl combin primari human bronchial epitheli cell obtain cf non cf patient differenti mucocili epithelia order assess effect corrector tezacaftor elexacaftor combin potenti ivacaftor key properti asl fluid reabsorpt viscos protein content ph treatment airway epithelia bear delet phenylalanin posit fdel cftr gene tezacaftor elexacaftor signific improv pericili fluid composit reduc fluid reabsorpt correct asl ph reduc viscos mucus kaftrio tm effect singl modul improv evalu paramet demonstr combin recent approv patient year older cystic fibrosi least one fdel mutat cftr gene repres valuabl tool defeat cf | D003550;D019005 | T047;T123;T116 |
36,232,696 | nmda receptor c termin domain signal develop matur diseas nmda receptor ca permeant glutam receptor play key role health diseas canon nmdar contain two glun subunit b predomin forebrain moreov relat contribut vs b control development activ depend manner glun subtyp influenc biophys properti receptor differ n termin extracellular domain transmembran region also larg cytoplasm carboxyl c termin domain ctds diverg substanti evolut ctd ident influenc nmdar subunit specif channel properti determin natur ctd associ signal molecul implic mediat control subunit composit vs b synaps histor much research differenti function glun ctds conduct vitro express mutant subunit recent generat knock ki mous model allow ctd function probe vivo ex vivo system without heterolog express glun mutant instanc find involv ki mice disagr model propos base earlier approach review examin current research aim address controversi methodolog may contribut differ studi also discuss outstand question regard role glun ctd sequenc regul nmdar subunit composit well relev neurodegen diseas neurodevelopment disord | D019636;D065886;D016194 | T047;T116;T048;T192 |
36,232,695 | bst novel inhibitori receptor involv nk cell cytotox cytoplasm tail domain bone marrow stromal cell antigen bst type ii transmembran protein express various cell type tether releas virus natur killer nk cell express low level bst normal condit exhibit increas express bst upon activ studi show first time murin bst control cytotox nk cell cytoplasm tail murin bst contain immunoreceptor tyrosin base inhibitori motif itim absenc bst nk cell enhanc cytotox tumor cell compar wild type nk cell nk cell isol nzw mice express itim defici bst also show higher cytotox wild type nk cell addit found galectin galectin ligand bst sinc block galectin monoclon antibodi enhanc cytotox nk cell result suggest bst might novel nk cell inhibitori receptor involv regul nk cell cytotox interact galectin | D000074010;D003602;D007694 | T043;T025;T123;T116 |
36,232,694 | target ezh promot chemosensit bcl inhibitor suppress pik c kit signal acut myeloid leukemia acut myeloid leukemia aml one common hematolog malign high heterogen character differenti block earli progenitor stage select bcl inhibitor venetoclax ven shown excit clinic result certain group aml patient howev ven alon insuffici reach endur complet respons lead concern ven resist altern combin therapi ven demand aml report synergist effect molecular mechan enhanc zest homolog ezh inhibitor dznep ven aml cell result show combin dznep ven signific induc cell prolifer arrest compar singl drug control aml cell primari sampl calcusyn analysi show signific synergi combin also signific promot apoptosi increas express pro apoptot protein whole transcriptom analysi show phosphoinositid kinas interact protein pikip pikaktmtor signal suppressor upregul upon dznep treatment moreov ezh upregul pikip downregul newli diagnos aml cohort compar healthi control higher express ezh associ poor outcom aml patient particular combin dznep ven dramat elimin cd c kit aml blast suggest effect combin tumor stem cell summari data indic dznep increas sensit ven aml affect pik c kit signal aml result also suggest therapeut target ezh bcl provid novel potenti combin strategi aml | D000970;D015470 | T121;T109;T191 |
36,232,693 | mitochondri dna repair neurodegen diseas age mitochondria organell along nucleus dna mitochondri dna mtdna doubl strand circular molecul kbp exist multipl copi within organell strand translat encod trnas rrnas protein mtdna molecul anchor inner mitochondri membran associ protein form structur call nucleoid exert structur protect function inde mitochondria evolv mechan necessari protect dna chemic physic lesion dna repair pathway similar present nucleus howev mitochondria specif mechan rapid mtdna turnov fission fusion mitophagi nevertheless mtdna mutat may abund somat tissu due main proxim mtdna oxid phosphoryl oxpho system consequ reactiv oxygen speci ros form atp product review summaris common type mtdna lesion mitochondria repair mechan second part review focus physiolog role mtdna damag age effect mtdna mutat neurodegen disord alzheim parkinson diseas consid central role mitochondria maintain cellular homeostasi analysi mitochondri function central point develop personalis medicin | D028361;D019636 | T047 |
36,232,692 | overview microrna diagnost prognost biomark high incid cancer microrna mirna small non code rnas ncrnas nucleotid size play import role gene regul involv almost major cellular physiolog process recent year abnorm express mirna shown associ human diseas includ cancer past ten year link mirna various cancer extens studi abnorm express mirna report various malign tumor lung cancer gastric cancer colorect cancer liver cancer breast cancer prostat cancer due high malign grade cancer necessari develop relat diagnost prognost method accord studi mirna mani potenti cancer biomark propos diagnosi prognosi diseas especi cancer thus provid new theoret basi perspect cancer screen use mirna biomark diagnosi prognosi cancer advantag less invas patient better accuraci lower price view import clinic signific mirna human cancer research articl review research status mirna mention cancer especi term diagnosi prognosi provid new perspect theoret basi diagnosi treatment cancer | D035683;D009369 | T191;T123;T114 |
36,232,691 | sequenc depend nanoscal structur cenp nucleosom cenp histon variant found high abund centromer human centromer histon variant replac histon h found throughout bulk chromatin addit centromer compris tandem repeat satellit dna cenp nucleosom assembl upon howev effect dna sequenc nucleosom assembl centromer format remain poor understood investig structur nucleosom assembl cenp variant use atom forc microscopi assembl cenp nucleosom h nucleosom dna substrat contain satellit motif character posit wrap effici also studi cenp nucleosom posit motif non specif dna compar relat posit stabil cenp nucleosom assembl satellit dna show posit prefer along substrat similar h nucleosom cenp nucleosom non specif dna rang nucleosom wrap effici narrow satellit dna compar non specif dna suggest stabl complex find indic dna sequenc histon composit may two mani factor requir accur centromer assembl | D048750;D002503;D000076247;D004247;D006657;D009707 | T116;T026;T123;T114;T129;T043;T079 |
36,232,690 | impair nucleolin activ phosphoryl trachyloban diterpen psiadia punctulata cancer cell human nucleolin hncl multifunct protein involv progress various cancer play key role patholog therefor still unsatisfi demand hncl modul recent demonstr plant ent kauran diterpen oridonin inhibit hncl unfortun compound quit toxic healthi cell trachyloban diterpen dihydroxi ent trachiloban oic acid compound extract psiadia punctulata dc vatk asteracea emerg ligand hncl cellular thermal shift assay cetsa base screen small librari diterpen effect interact compound protein demonstr occur vitro insid two differ type cancer cell base experiment comput data model hnclcompound complex built bind hncl mrna chaperon activ signific reduc level phosphoryl protein affect biolog level cancer cell incub compound produc cell cycl block subgg phase induc earli apoptosi wherea cytotox toward healthi cell observ overal result suggest dihydroxi ent trachiloban oic could repres select antitumor agent promis lead design innov hncl inhibitor also usabl therapeut purpos | D019659;D004224;D045786;D009369 | T191;T109;T002 |
36,232,689 | genom wide identif express analysi cytokinin respons regul rr gene woodi plant jatropha curca function analysi jcrr arabidopsi cytokinin ck respons regul rr gene famili play pivot role regul development environment respons plant axillari bud outgrowth perenni woodi plant jatropha curca regul crosstalk ck gibberellin ga studi first analyz effect gibberellin ga lovastatin ck synthesi inhibitor decapit interact outgrowth axillari bud result indic lovastatin complet inhibit ga promot axillari bud outgrowth partial weaken decapit promot axillari bud outgrowth character understand role ck signal promot develop femal flower branch perform bioinformat express analys character ck rr gene jcrr famili j curca total member jcrr famili identifi gene distribut chromosom phylogenet analysi indic correspond rr protein evolutionarili conserv across differ plant speci myb like dna bind domain divid member jcrr famili type type b protein analysi cis act element promot region jcrrs suggest jcrrs express respons phytohormon light abiot stress factor thus jcrrs may involv plant develop process genom sequenc comparison reveal segment duplic may play crucial role expans jcrr gene famili five pair duplic gene subject purifi select analyz rna sequenc rna seq quantit revers transcript polymeras chain reaction qrt pcr data character temporospati express pattern jcrrs develop various tissu respons gene phytohormon abiot stress jcrrs main express root also exhibit differenti express pattern tissu express level six type one type b jcrrs increas respons benzylaminopurin ba four type b jcrrs level decreas express level two type b jcrrs increas respons exogen ga treatment three type three type b jcrrs decreas found type jcrrs may play posit role continu growth axillari bud role type b jcrrs might opposit respons abiot stress express level two type three type b jcrrs strong increas overexpress jcrr arabidopsi thaliana slight increas number rosett branch decapit normal condit conclus result provid detail knowledg jcrrs analysi ck signal jcrr function j curca | D017360;D049248;D031286 | T037;T002 |
36,232,688 | fbp alter carbohydr metabol reduc leukem viabil activ p modul mitochondri qualiti control system vitro acut myeloid leukemia aml frequent form adult blood cancer character heterogen mechan diseas progress develop effect therapeut strategi target metabol homeostasi energi product immatur leukem cell blast essenti overcom relaps improv prognosi aml patient differ subtyp respect metabol regul fructos bisphosphatas fbp gluconeogen enzym vital carbohydr metabol sinc gluconeogenesi central pathway product import metabolit energi necessari maintain normal cellular activ beyond catalyt activ fbp inhibit aerob glycolysi known warburg effect cancer cell import downregul fbp associ carcinogenesi major human organ restor fbp cancer cell promot apoptosi prevent diseas progress solid tumor recent larg scale sequenc analys reveal fbp novel induc therapeut target among vitamin respons gene mv molm blast vitro deriv aml patient flt mutat investig fbp anti leukem function studi generat new aml cell line lentivir overexpress fbp transgen vitro name fbp mv result show fbp mv blast prone apoptosi mv blast mechanist fbp mv blast signific increas gene protein express p confirm p promot assay vitro howev enhanc cell death reduc prolifer fbp mv blast could revers supplement post glycolyt metabolit vitro addit fbp mv blast found impair mitochondri homeostasi reduc cytochrom c oxidas subunit cox mt co upregul pten induc kinas pink express summari first vitro evid fbp alter carbohydr metabol fbp activ p initi leukem death activ mitochondri reprogram aml blast support clinic potenti fbp base therapi aml like cancer | D050260;D042381;D015470;D008928;D016159 | T116;T043;T026;T191;T123;T025;T044 |
36,232,687 | improv salin toler associ variabl observ em mutagen wheat line salin toler associ phenotyp em mutagen wheat line origin bari gom compar veget growth measur use non destruct imag base phenotyp five differ nacl concentr mm appli plant day plant dap plant imag daili dap plant growth water use leaf na k cl content thousand kernel weight tkw measur six line select analysi salin condit leaf na k cl content variat dri weight basi within six line fold respect relat bari gom two oa oa line greater k accumul three oa oa oa lower na k ratio oa greater water use index wui oa fold greater leaf na maintain tkw relat bari gom two line oa oa greater tkw bari gom grown mm nacl similar na k wui biomass accumul oa relat high tkw high leaf k wui low leaf na cl phenotyp variat reveal differ associ paramet measur line futur identif genet basi differ cross line phenotyp interest expect enabl assess combin paramet deliv greatest improv salin toler | D055049;D014908 | T168;T040;T002 |
36,232,686 | oxid stress contributor insulin resist skelet muscl mice polycyst ovari syndrom polycyst ovarian syndrom pcos reproduct endocrin metabol disord circul marker oxid stress abnorm women pcos close relationship oxid stress insulin resist ir howev littl inform avail oxid stress skelet muscl affect pcos studi pcos induc prepubert cblj mice inject dehydroepiandrosteron oxid stress biomark measur serum skelet muscl under mechan investig cc myotub treat testosteron discov increas oxid biomark increas ros product damag insulin sensit skelet muscl mice pcos high level caus mitochondri dysfunct increas ros level androgen receptor ar nicotinamid adenin dinucleotid phosphat oxidas nox signal pathway cc cell treatment cc cell antioxid n acetylcystein nac decreas induc ros product improv mitochondri function revers ir administr nac mice pcos improv insulin sensit skelet muscl anim hyperandrogen caus mitochondri dysfunct redox imbal skelet muscl mice pcos discov oxid stress contribut skelet muscl ir pcos reduc ros level may improv insulin sensit skelet muscl patient pcos | D007333;D011085 | T047;T046 |
36,232,685 | lysyl oxidas orchestr cellular behavior ecm remodel homeostasi lysyl oxidas long consid key secret extracellular matrix modifi enzym activ associ crosslink collagen elastin result link multipl development patholog process howev numer line evid also demonstr member enzym famili local activ within cytoplasm cell nuclei regul particip distinct cellular event review focus event highlight intracellular role enzym play close examin event suggest intracellular activ lysyl oxidas most observ process concomit chang extracellular matrix take place suggest lox famili member act relay chang cell environ intracellular process promot follow | D004549;D008249 | T126;T123;T116 |
36,232,684 | italian research molecular character maiz kernel develop studi genet control maiz seed develop seed relat pathway one import theme approach italian scientif communiti maiz alway attract interest italian communiti agricultur genet sinc begin founder base research project develop school adopt maiz refer speci spent period unit state maiz alreadi becom model system receiv train manuscript illustr research work carri itali differ group studi maiz kernel underlin contribut elucid fundament aspect caryopsi develop character maiz mutant sinc research project aim comprehens genet control seed develop regul storag product biosynthes accumul base forward genet approach also document decad italian group main base northern itali contribut improv knowledg maiz genom fundament intern studi focus correct differenti pattern maiz kernel compart strong contribut recent advanc maiz research | D012639;D003313 | T168;T002 |
36,232,683 | compar physiolog transcriptom analys improv heat stress toler celeri apium graveolen l caus exogen melatonin melatonin mt crucial plant growth develop respons stress celeri veget grow cool climat hot climat deterior growth yield qualiti studi investig effect exogen melatonin celeri physiolog transcript level analyz spray celeri exogen mt expos high temperatur regulatori mechan exogen mt mediat heat toler examin result show exogen mt reduc thermal damag state celeri seedl well malondialdehyd mda content relat conduct rec increas oxidas activ osmot regulatori substanc chlorophyl enhanc leaf transpir light energi util effici examin mechan exogen mt mitig high temperatur damag use transcriptom sequenc method total gene express differ high temperatur celeri treat mt compar untreat celeri function annot analysi reveal differenti express gene abund pyruv metabol pathway peroxidas activ pathway accord pathway base gene express analysi exogen mt inhibit upregul pyruv synthesi gene downregul pyruv consumpt gene prevent accumul pyruv rapid upregul express peroxidas gene therebi enhanc peroxidas activ rt qpcr verif show rise encod peroxidas gene express mt treatment gene express pattern involv pyruv anabol metabol agre abund transcriptom express valid physiolog index result result indic applic exogen mt celeri signific enhanc abil plant remov reactiv oxygen speci ros respons heat stress therebi improv abil plant resist heat stress result studi provid theoret basi use mt allevi damag caus heat stress plant growth develop | D000077102;D008550;D000071436 | T002;T121;T039;T109;T125 |
36,232,682 | arrang hydrogen bond aqueous solut differ globular protein work present first evid dissolv globular protein chang arrang hydrogen bond water differ protein show quantit differ effect use atr ftir attenu total reflect fourier transform infrar spectroscop analysi oh stretch band obtain quantit estim relat amount previous report four subpopul water structur coexist varieti aqueous solut solvatochrom dye measur properti solut non ionic polym result correl well atr ftir measur protein solut solvatochrom dye probe appli nmr nuclear magnet reson spectroscopi use first time estim hydrogen bond donor acid water found strong correl solvent acid arrang hydrogen bond aqueous solut sever globular protein even quit similar protein found chang water properti dramat differ way | D011506;D014867 | T121;T123;T116;T197 |
36,232,681 | molecular advanc mafld link sphingolipid extracellular matrix develop progress fibrosi metabol associ fatti liver diseas mafld major caus liver diseas global preval expect grow come decad main caus mafld develop chang composit extracellular matrix ecm increas product matrix molecul inflammatori process lead progress fibrosi cirrhosi ultim liver failur addit increas accumul sphingolipid accompani increas express pro inflammatori cytokin ecm close relat lipogenesi mafld develop progress fibrosi work summar inform regard role sphingolipid eg ceramid sp mafld develop sphingolipid seem signific effect macrophag consequ hscs trigger entir cascad overproduct matrix molecul especi type iii collagen proteoglycan elastin also tissu inhibitor metalloproteinas result caus develop liver fibrosi | D065626;D013107 | T047;T109 |
36,232,680 | dystoc labor adrenerg noradrenerg neurotransmitt morpholog experiment studi author investig catecholaminerg neurotransmitt chns quantit modif pregnant uterin lower uterin segment lus prolong labor pl fetus occiput posterior posit opp occiput transvers posit otp fetal head asynclit diagnos intrapartum ultrasonographi iu chns neurotransmitt particular adrenalin epinephrin noradrenalin norepinephrin n evalu lus fragment sampl cs patient undergo urgent cesarean section cs pl compar chns fiber lus women submit elect cs result statist analyz understand differ neurotransmitt morpholog analysi scan electron microscopi examin sem lus fragment analysi reveal reduct n fiber lus pl compar express n fiber lus elect cs pl opp otp asynclit posit caus dystocia labor lead reduct neurotransmitt lus uterin vascular modif reduct contractil smooth uterin cell n neurotransmitt reduct observ pl negat interfer uterin contract labor | D002585;D004420 | T061;T046;T079 |
36,232,679 | treatment effect platelet gel reconstruct bone defect nonunion review vivo human studi ideal circumst fractur bone heal proper aid clinic intervent howev around bone fractur fail heal proper within expect time even aid clinic intervent result nonunion platelet gel blood deriv biomateri use regen medicin aim promot wound heal regener damag tissu purpos paper review relev articl attempt explor current consensus treatment effect platelet gel reconstruct bone defect nonunion hope provid valuabl refer clinician make treatment decis clinic practic base present review studi appli combin platelet gel bone graft reconstruct bone defect nonunion result posit suggest treatment strategi could promot success reconstruct bone defect nonunion two studi tri appli platelet gel alon reconstruct bone defect nonunion therefor convinc conclus could made yet regard treatment effect platelet gel alon reconstruct bone defect nonunion one studi appli platelet gel combin extracorpor shock wave therapi reconstruct nonunion result posit hypothet mechan treatment strategi reason sound futur clinic studi encourag justifi effect promis treatment strategi conclus applic platelet gel could promis use treatment method reconstruct bone defect nonunion futur clinic studi encourag investig effect promis treatment method | D050723;D005599 | T046;T037 |
36,232,678 | map qtls reproduct stage salin toler rice use cross hasawi brri dhan salin stress major constraint rice product mani coastal region due salin groundwat river sourc especi dri season coastal area seawat intrud inland due reduc river flow sinc salin toler complex trait breed effort assist map quantit trait loci qtls complementari salt toler mechan combin provid higher level toler abund seedl stage salin toler qtls map studi investig reproduct stage toler rice due difficulti achiev reliabl stage specif phenotyp techniqu current studi bc f map popul consist individu deriv cross salt toler saudi arabian varieti hasawi salt sensit bangladeshi varieti brri dhan evalu yield compon exposur ec dsm salin stress reproduct stage select toler sensit progeni individu genotyp skim sequenc result high qualiti singl nucleotid polymorph snp marker subsequ total qtls identifi key trait includ product tiller number percent fill spikelet grain yield stress import three yield relat qtls one product tiller qpt number fill spikelet qnfs grain yield qgi salin stress map posit mb cm chromosom previous associ grain yield salin stress qtls investig dissect molecular mechan under reproduct stage salin toler rice | D012275;D000069600;D040641;D055049 | T168;T040;T002;T028 |
36,232,677 | progress current status hajdu cheney syndrom focus novel genet research hajdu cheney syndrom hcs rare autosom domin manifest congenit genet disord caus mutat notch gene notch signal variat notch maintain homeostasi determin regul prolifer differenti various cell hcs accumul notch caus abnorm bone resorpt due continu excess signal hcs character progress bone destruct complex wide rang clinic manifest signific impact patient qualiti life howev effect treatment establish hcs date genet variant notch report clinvar databas us nation institut health total mutant variant detect base american colleg medic genet genom acmc date comprehens compil hcs mutat review provid comprehens list possibl hcs variant nucleotid chang amino acid definit molecular consequ report date follow acmc guidelin | D031845 | T047 |
36,232,676 | citicolin eye drop protect trabecular meshwork cell oxid stress injuri vitro glaucoma model intraocular pressur iop consid import modifi risk factor glaucoma known second lead caus blind worldwid howev lower iop alway suffici preserv vision due non iop depend mechan involv improv outcom adjunct therapi iop independ target requir date studi shown effect citicolin trabecular meshwork tm even though known possess neuroprotectiveenhanc properti multifactori mechan action given reactiv oxygen speci seem involv glaucomat cascad present studi advanc millifluid vitro model use evalu citicolin could exert valid tm protect oxid stress end cellular behavior term viabil apoptosi mitochondri state senesc pro inflammatori cytokin human tm cell treat either h alon cotreat citicolin analyz preliminari vitro result suggest counteract effect citicolin eye drop oxid stress tm cell though studi necessari explor citicolin potenti tm target therapi | D005901;D014129 | T047;T023 |
36,232,675 | antimicrobi photodynam effect cross kingdom microorgan toluidin blue potassium iodid streptococcus mutan mutan candida albican c albican promin microb associ rapid aggress cari present studi investig antimicrobi efficaci cytotox mechan toluidin blue tbo mediat antimicrobi photodynam therapi apdt potassium iodid ki depend ki concentr tbo concentr light dose antimicrobi effect apdt plus ki determin cytotox tbo mediat apdt plus ki analyz cell count kit cck assay singlet oxygen probe test time resolv detect quencher experi perform evalu role apdt plus ki generat iodin hydrogen peroxid h analyz iodin starch test amplex red assay anti biofilm effect tbo mediat apdt plus ki also evalu count form unit cfu assay ki could potenti tbo mediat apdt mutan c albican plankton biofilm state safe human dental pulp cell measur show ki could quench signal implic may act princip mediat oxid excess iodid ion form iodin h ki could high potenti tbo mediat apdt erad mutan c albican due synergist effect molecular iodin h | D000890;D007455;D010778 | T121;T061;T123;T196 |
36,232,674 | glabridin bioactiv flavonoid licoric effect inhibit platelet activ human mice platelet crucial hemostasi arteri thrombosi may lead sever cardiovascular diseas cvds thus therapeut agent must develop prevent patholog platelet activ glabridin major bioalkaloid extract licoric root improv metabol abnorm ie obes diabet protect cvds neuron disord best knowledg studi focus glabridin effect platelet activ therefor investig effect human mice glabridin exhibit highest inhibitori effect collagen stimul platelet aggreg moder effect arachidon acid stimul activ howev effect observ agonist eg thrombin u glabridin evid reduc p selectin express atp releas intracellular ca ca mobil thromboxan format reduc activ phospholipas c plc protein kinas c pkc phosphoinositid kinas pik aktglycogen synthas kinas gsk mitogen activ protein kinas mapk nf b mice glabridin reduc mortal rate caus acut pulmonari thromboembol without alter bleed time thus glabridin effect inhibit plcpkc cascad prevent activ pikaktgsk mapk pathway lead reduct ca mobil eventu inhibit platelet aggreg therefor glabridin may promis therapeut agent thromboembol disord | D006035;D019007 | T116;T002;T129 |
36,232,673 | calcium base antimicrobi peptid compound attenu dnfb induc atop dermat like skin lesion via th cell balbc mice atop dermat ad chronic recurr inflammatori skin diseas character sever itch recurr skin lesion hypothes novel treatment involv calcium base antimicrobi peptid compound capc combin natur calcium extract marin shellfish varieti antimicrobi peptid may benefici ad establish dinitrofluorobenzen dnfb induc ad model balbc mice test hypothesi observ mous behavior conduct histopatholog immunohistochem analys skin lesion capc treatment also character chang level cytokin inflammatori mediat toll like receptor tlrs plasma skin lesion result show topic applic capc amelior ad like skin lesion reduc scratch behavior balbc mice ii capc suppress infiltr inflammatori cell inhibit express inflammatori cytokin ad like skin lesion iii capc reduc plasma level inflammatori cytokin iv capc inhibit tlr tlr protein express skin lesion topic applic capc exhibit therapeut effect ad inhibit inflammatori immun respons via recruit helper cell engag tlr tlr signal pathway therefor capc may use treatment ad | D003876 | T047 |
36,232,672 | metallophenolom novel integr approach studi complex plant phenol metalmetalloid ion plant adapt strategi shape evolutionari develop constant interact plethora environment factor includ presenc metalsmetalloid environ among adapt reaction either excess trace element toxic dose non essenti element complex molecular endogen ligand includ phenol receiv increas attent current complex phenol metal loid topic intens studi differ scientif field spite numer studi chelat capac system analysi phenol plant ligand perform yet systemat perform base modern approach metallom integr biomet scienc turn differenti subgroup accord natur bioligand regard present review summar phenol metal loid interact use metallom approach experiment result chelat activ repres compound differ phenol subgroup vitro vivo systemat general properti phenol ligand specif properti anthocyanin reveal novel concept metallophenolom propos ligand orient subgroup metallom integr approach studi phenol metal loid complex research subject metallophenolom outlin accord methodolog metallom studi includ mission orient biomet scienc environment scienc food scienc nutrit medicin cosmetolog color technolog chemic scienc materi scienc solar cell scienc metallophenolom open new prospect unit multidisciplinari investig phenol metal loid interact | D058955;D014131 | T121;T196;T123 |
36,232,671 | function expression analys reveal distinct role complement factor regul complement system activ gcrv infect ctenopharyngodon idella complement factor cfi complement inhibitor well known regul complement system activ degrad complement compon b cb anim serum thus becom involv innat defens nevertheless function mechan cfi complement system host pathogen interact far clarifi teleost fish present studi clone character cfi gene cicfi grass carp ctenopharyngodon idella analyz function degrad serum cb express chang grass carp reovirus gcrv infect open read frame cicfi found bp encod amino acid molecular mass kda pairwis align show cicfi share highest ident cfi carassius gibelio highest similar cfi danio rerio cicfi protein character conserv function core trypspc domain catalyt triad substrat bind site phylogenet analysi indic cicfi homolog cfis teleost fish form distinct evolutionari branch similar cfis report mammal recombin cicfi protein could signific reduc cb content serum demonstr conserv function cicfi complement system grass carp cicfi mrna protein show highest express level liver gcrv infect mrna express cicfi first regul regul regul initi level protein express level maintain overal downward trend late stage infect liver grass carp unexpect protein level cicfi also continu regul serum grass carp gcrv infect content serum cb protein first increas return initi level suggest distinct role cicfi regul complement activ fish virus interact combin previous result complement factor complement enhanc show continu regul express level grass carp gcrv infect studi may provid essenti data full pictur complex complement regul mechan mediat df cfi grass carp pathogen infect | D002347;D005393;D012087;D012088 | T047;T005;T013 |
36,232,670 | gadolinium accumul toxic vitro grown stevia rebaudiana case studi gadobutrol gadolinium base contrast agent molecular complex extens use diagnost purpos apart tremend contribut diseas diagnost sever issu relat use extrem stabl complex potenti contamin surfac ground water issu document worldwid irrig field contamin surfac water fertil sludg wastewat treatment plant lead introduct gd human food suppli chain thus studi focus potenti toxic gd plant purpos studi molecular effect gadobutrol well known mri contrast agent exposur vitro grown stevia rebaudiana effect gadobutrol plant morpholog relev plant metabolit chlorophyl carotenoid ascorb acid hplc miner icp oe generat free radic speci mda assay epr assess exposur mm gadobutrol use found correl gadobutrol dose plant growth concentr metabolit mm dose gadobutrol toxic effect gd ion becam signific | D009942;D036625 | T109;T002 |
36,232,669 | photochem consider interact blood protein layer inorgan materi interact layer doubl hydroxid ldh nanomateri plasma protein accord particl size surfac charg evalu ldhs differ particl size nm prepar adjust hydrotherm treatment urea hydrolysi subsequ organ coat citrat malit serit appli control surfac charg potenti mv adsorpt isotherm stern volmer plot fluoresc quench indic human blood plasma weak interact toward type ldhs adsorpt isotherm show signific differ size surfac charg fluoresc quench ratio increas increas surfac charg impli electrostat interact play major role interact fluoresc quench three type plasma protein human serum albumin globulin fibrinogen surfac charg control ldhs suggest protein adsorb ldhs singl layer addit protein weak adsorb surround ldhs adsorb protein conclud ldh nanomateri fair compat blood compon due protein corona electrostat interact affect interact protein | D000066970 | T116 |
36,232,668 | cytotox effect isol cannabinoid extract polypoid colorect tissu purifi cannabinoid shown prevent prolifer induc apoptosi colorect carcinoma cell line assess cytotox effect cannabinoid extract purifi cannabinoid colorect polyp normal colon cell well synergist interact various blend test identifi optim synergist effect method biopsi polyp healthi colon tissu obtain patient undergo colon polypectomi toxic varieti cannabinoid extract purifi cannabinoid differ concentr evalu synergist effect cannabinoid calcul base cell surviv isol cannabinoid illustr differ toxic effect viabil cell deriv colorect polyp thc thc toxic exhibit persist toxic polyp test cbd toxic polypoid cell comparison normal colon cell concentr combin cannabinoid cbdv thcv cbdva cbca cbga exhibit synergist inhibitori effect viabil cell deriv colon polyp patient isol cannabinoid compound interact synergist colon polyp also possess differenti toxic effect polyp adjac colon tissu suggest possibl futur therapeut valu | D000970;D002185;D002186;D002188;D003111;D015179 | T002;T167;T121;T191;T109;T190 |
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