PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,229,704 | low cost mitig strategi communiti resili tran himalaya address food water scarciti chang environ food water scarciti high altitud tran himalayan landscap seen impact climat chang character prolong winter sub zero temperatur longer period averag daili temperatur oct mar rang c howev fluctuat c minimum c maximum typic day minim rainfal agricultur limit one season cold desert thus limit land product chang scenario affect water avail agricultur otherwis villag locat high altitud depend snowmelt flow nearbi stream studi explor potenti extend cultiv winter use low cost input compar differ technolog option temperatur retent veget cultiv demonstr role peopl particip develop zero energi artifici ice reservoir water harvest technolog captur store water form ice winter make water avail follow grow season site specif modif artifici ice reservoir creat villag provid addit water irrig time avail day advanc use addit water barren area brought plantat meet futurist wood fodder requir confid build knowledg gather intervent solv major problem water scarciti local adapt solut portabl polyhous ice reservoir increas plant product motiv high altitud villag tran himalayan combat threat climat chang | D007053;D000085222 | T197;T070 |
36,229,681 | structur basi activ fungal sterol receptor upc azol resist fungal transcript factor upc sens ergosterol level regul sterol biosynthesi uptak constitut activ upc caus azol resist candida speci determin structur ergosterol bound upc reveal ligand specif transcript regul ergosterol bind involv conform chang ligand bind domain creat shape complementari hydrophob pocket conserv helix glycin rich loop critic sterol recognit form pocket wall mutat glycin rich loop inhibit ligand bind steric clash constitut activ upc transloc upc regul hsp chaperon sterol depend manner ergosterol bound upc associ hsp use c termin tail retain inact upc cytosol ergosterol dissoci induc conform chang c termin tail releas upc hsp nuclear transport importin understand regulatori mechan provid antifung target treatment azol resist candida infect | D001393;D000935 | T121;T109;T195 |
36,229,668 | social accept public breastfeed time experi attitud popul breastfeed mother germani moder breastfeed friend accord systemat inventori base refer studi survey accept breastfeed public conduct aim work captur percept attitud toward public breastfeed period comparison addit differ general popul mother young children well mother differ level educ consid | D001942;D009035 | T092;T058;T055;T099;T040 |
36,229,662 | potent antibiot load bone cement implant staphylococc bone infect new antibiot ideal exhibit activ drug resist bacteria delay develop bacteri resist suitabl local deliveri desir site infect report ration design via molecular dock simul librari candid antibiot bone infect wild type mutat bacteri target screen librari activ multidrug resist clinic isol identifi antibiot exhibit potent activ resist strain format biofilm decreas chanc bacteri resist compat local deliveri via bone cement matrix antibiot load bone cement exhibit greater efficaci current use antibiot load bone cement staphylococc bone infect rat potent local deliv antibiot elut polym may help address antimicrobi resist | D001843;D000900 | T121;T122;T195 |
36,229,661 | collagen bind peptid enhanc imag lubric regener osteoarthrit articular cartilag treatment osteoarthr would benefit enhanc visual injur articular cartilag target deliveri diseas modifi drug use ex vivo human osteoarthrit cartilag live rat minipig induc osteoarthr report applic collagen bind peptid identifi via phage display home osteoarthrit cartilag detect via magnet reson imag conjug superparamagnet iron oxid compar use peptid scrambl sequenc hyaluron acid conjug collagen bind peptid display enhanc retent osteoarthrit cartilag better lubric human osteoarthrit tissu ex vivo mesenchym stromal cell encapsul modifi hyaluron acid inject intra articular rat show enhanc home osteoarthrit tissu improv regener molecular dock reveal wxpxw consensus motif bind chain collagen type xii peptid specif bind osteoarthrit tissu may aid diagnosi treatment osteoarthrit joint | D002358;D010003 | T047;T024 |
36,229,654 | retrospleni subicular input converg superfici project layer v neuron medial entorhin cortex medial entorhin cortex mec play pivot role spatial process togeth hippocamp format retrospleni cortex rsc also implic process thus relev understand structur interact requir precis knowledg connect project neuron rsc synaps onto princip neuron layer v mec neuron send axon superfici layer mec layer v mec also main target hippocamp effer subiculum ca field aim studi assess whether popul cell target rsc project also receiv input hippocamp format compar distribut synapt contact target dendrit label cell layer v mec inject retrograd tracer superfici layer time label rsc subicular project differ anterograd tracer reconstruct label cell axon reveal like synapt contact presynapt bouton origin postsynapt mec layer v basal dendrit moreov contact overlap dendrit segment without target specif domain result support notion mec layer v neuron project superfici layer receiv converg input rsc subiculum data thus suggest converg subicular rsc inform contribut signal neuron superfici layer ec send hippocamp format | D018728;D009474 | T023;T025;T029 |
36,229,648 | synthesi powder bead chitosan materi modifi zno remov lead ii ion lead contamin wastewat may affect aquat organ environ human consumpt high toxic metal caus human health effect thus recommend remov lead releas environ powder bead chitosan materi modifi zno synthes investig various character techniqu lead remov effici chitosan materi studi batch experi adsorpt isotherm kinet chitosan powder cp chitosan bead cb chitosan bead mix zno czb chitosan bead coat zno zcb synthes cp repres semi crystallin structur cb amorph structur czb zcb semi crystallin structur zno peak cp scali sheet coars surfac cb czb zcb sphere shape scali sheet surfac c n main chemic element chitosan materi zn detect czb zcb h n h c main function group chitosan materi chitosan materi high lead remov effici freundlich pseudo second order kinet model well explain adsorpt pattern mechan therefor ad metal oxid chang materi form recommend improv materi effici zcb good offer industri applic | D048271;D014874;D015034 | T121;T109;T131;T197 |
36,229,647 | contrast level hybrid across two contact zone two hedgehog speci reveal genom wide snp data hybrid introgress play import role histori various speci includ lineag diversif evolut adapt trait hybrid acceler develop reproduct isol diverg speci thus valuabl insight evolut reproduct barrier format may gain studi secondari contact zone hedgehog genus erinaceus insectivor sensit chang climat pioneer model pleistocen phylogeographi present studi provid first genom wide snp data regard erinaceus hedgehog speci complex offer uniqu comparison two secondari contact zone erinaceus europaeus e roumanicus result confirm diversif genus pleistocen period detect new refugi lineag e roumanicus outsid mediterranean basin like ponto caspian region central european zone level hybrid low wherea russian baltic zone speci hybridis extens asymmetr gene flow e europaeus e roumanicus suggest reproduct isol vari accord direct cross hybrid zone howev loci signific differ pattern introgress detect mark differ pre post zygot barrier thus divers mode speci boundari mainten two contact zone like exist pattern probabl consequ differ age thus differ stage evolut reproduct isol mechan hybrid zone | D006364;D006824 | T015;T045 |
36,229,645 | evalu circul small extracellular vesicl deriv mirna diagnost biomark differenti differ patholog type earli lung cancer lung cancer lead caus cancer relat death worldwid microrna mirna circul small extracellular vesicl sev suggest potenti biomark cancer diagnosi present studi design explor whether plasma deriv sev mirna could util diagnost biomark differenti earli stage small cell lung cancer sclc earli stage non small cell lung cancer nsclc compar mirna profil plasma deriv sev healthi individu patient earli stage sclc patient earli stage nsclc next generat sequenc use screen differenti express mirna dem gene ontolog go kyoto encyclopedia gene genom kegg pathway analys use predict potenti function dem weight gene coexpress network analysi wgcna use identifi differ patholog relat mirna modul found dem signific differ among healthi individu patient earli stage sclc patient earli stage nsclc select six repres dem valid qrtpcr confirm mirna p deriv plasma sev could use potenti biomark diagnosi earli stage sclc mirna p mirna p could use diagnosi earli stage nsclc respect | D002289;D000074166;D000067128;D008175;D035683;D055752 | T191;T026;T123;T114 |
36,229,644 | estim systol blood pressur random forest use heart sound ballistocardiogram cuffless blood pressur measur enabl unobtrus continu monitor integr wearabl devic extend healthcar non hospit set current research focus estim blood pressur base puls transit time puls arriv time use ecg peripher cardiac puls signal proxim time refer studi propos use phonocardiogram pcg ballistocardiogram bcg two signal detect noninvas estim systol blood pressur sbp pcg bcg simultan measur volunt rest activ post activ condit differ featur consid base relationship signal interv pcg j k wave bcg statist analyz ij jk slope also estim addit featur train machin learn algorithm interv j k j negat correl chang sbp p val featur use explanatori variabl regressor base random forest possibl estim systol blood pressur mean error mmhg standard deviat mmhg therefor forese propos potenti applic wearabl devic use low cost embed system | D001450;D006347 | T042;T060 |
36,229,643 | alzheim diseas larg scale gene express portrait identifi exercis top theoret treatment alzheim diseas ad complex neurodegen disord affect multipl brain region difficult treat studi use ad larg scale gene express dataset identifi consist under portrait ad gene express across multipl brain region use portrait platform identifi treatment could revers ad dysregul express pattern enrich dysregul ad gene includ multipl process rang cell adhes cns develop three dysregul gene ad portrait inositol trisphosph kinas itpkb upregul astrocyt specif intermedi filament protein gfap upregul rho gtpase rhoq upregul top ad dysregul gene also identifi recent human ad gwas studi includ pnoc cb bcla transcript factor identifi dysregul ad turn affect express ad dysregul gene male femal ad portrait high congruent treatment three dataset exercis activ identifi top three theoret treatment ad via revers larg scale gene express pattern exercis revers express pattern hundr ad gene across multipl categori includ cytoskeleton blood vessel develop mitochondrion interferon stimul relat gene exercis also rank best treatment across major individu region specif ad dataset meta analysi ad dataset fluoxetin also score well theoret combin fluoxetin exercis revers ad gene posit treatment includ curcumin comparison ad portrait recent depress portrait reveal high congruenc downregul gene togeth ad portrait provid new platform understand ad identifi potenti treatment ad | D000544;D003474 | T047;T121;T109;T130;T048 |
36,229,641 | risk factor stroke recurr patient hemorrhag stroke risk factor recurr hemorrhag ischem stroke patient intracrani hemorrhag ich inconclus studi design investig risk factor stroke recurr impact antiplatelet stroke recurr patient ich popul base case cohort studi analyz data obtain random sampl million subject taiwan nation health insur research databas surviv patient hemorrhag stroke januari decemb includ studi year follow period recurr rate stroke hemorrhag stroke ischem stroke recurr rate stroke without antiplatelet group antiplatelet group risk factor hemorrhag stroke hypertens risk factor ischem stroke age diabet mellitus hypertens atrial fibril cardiovascular diseas ischem stroke histori antiplatelet may decreas risk hemorrhag stroke risk stroke recurr high patient ich hypertens risk factor ischem hemorrhag stroke recurr antiplatelet therapi decreas risk ischem stroke recurr may reduc recurr hemorrhag stroke | D000083302;D020521 | T047 |
36,229,640 | three year migrat analysi new metaphys anchor short femor stem tha use ebra fca cementless calcar guid femor short stem total hip arthroplasti tha becom increas popular year earli distal migrat femor stem measur einzel bild roentgen analys femor compon analys ebra fca report risk factor asept loosen aim studi analys axial migrat behavior subsid new short stem launch follow period year accord studi protocol hip osteoarthr patient consecut receiv unilater cementless calcar guid short stem ananova proxi singl depart prospect includ mid term follow studi thirteen patient lost follow result patient unilater tha fulfil criteria migrat analysi ebra fca cohort compris male mean age mean bmi bodi mass index femal mean age mean bmi seven standard radiograph per patient analyz ebra fca averag migrat mm observ within first year median increas first year higher second third year mm iqr vs mm iqr mm vs mm iqr mm detect migrat lead stem loosen instabl disloc revis surgeri patient higher risk subsid observ male heavyweight patient wherea femal gender associ lower risk correl migrat revis could observ although moder subsid detect perform short stem ananova proxi encourag yet use may consid overweight male patient due pronounc subsid | D019644;D006622;D015207 | T061;T047;T074 |
36,229,637 | overexpress mous prion protein transgen mice caus non transmiss spongiform encephalopathi transgen mice express human prnp murin prnp transgen mous prion protein knockout background made key contribut understand human prion diseas provid basi mani fundament advanc prion biolog includ first report synthet mammalian prion regard prion paradigm increas guid explor seed protein misfold pathogenesi neurodegen diseas report well establish wide use line mice tg tga overexpress wild type mous prion protein exhibit spontan aggreg accumul misfold prion protein strong age depend manner accompani focal spongiosi occasion neuron loss case clinic syndrom develop phenotyp featur close resembl seen prion diseas howev passag brain homogen affect age mice fail transmit syndrom inocul intracerebr recipi anim conclud overexpress wild type mous prion protein caus age depend protein misfold disord proteinopathi associ product infecti agent produc phenotyp close similar authent prion diseas | D001927;D017096;D011328 | T047;T116;T005 |
36,229,636 | stabl isotop c n differ abil reconstruct diet cattl fed c c forag diet stabl isotop use estim livestock diet select object compar c n estim diet proport c c forag steer bos spp fed quantiti rhizoma peanut arachi glabrata rp c bahiagrass paspalum notatum c treatment proport rp bahiagrass hay bahiagrass rp rp bahiagrass rp rp bahiagrass rp rp bahiagrass rp rp rp fece plasma red blood cell rbc hair collect day interv day two pool mix model util back calcul proport rp base sampl forag c n fece show chang use c day adj r predict observ rp proport day plasma hair rbc requir beyond day reach equilibrium therefor use predictor diet composit studi diet best repres use fecal c day day day fecal n show promis r predict diet composit c c diet studi warrant corrobor fecal n predictor diet composit cattl | D004032;D031781 | T168;T002 |
36,229,634 | blood pressur variabl plasma alzheim diseas biomark older adult blood pressur variabl emerg risk factor alzheim diseas older adult independ averag blood pressur level grow evid suggest increas blood pressur variabl link alzheim diseas pathophysiolog index cerebrospin fluid positron emiss tomographi marker relationship plasma alzheim diseas marker investig cross section studi communiti dwell older adult age mean age sd elev blood pressur variabl min associ lower level plasma standard ci p adjust r ratio ci p adjust r higher level total tau ci p adjust r ptau ratio ci p adjust r find suggest higher blood pressur variabl link plasma biomark increas alzheim diseas pathophysiolog | D000544 | T047;T048 |
36,229,633 | explor spatiotempor interact superior time space space time mutual influenc space affect time estim space time effect convers time space effect reciproc interfer suggest space time intrins link human mind yet recent evid asymmetr advantag space time challeng classic theoret interpret present studi test whether superior space time magnitud interfer depend cognit resourc engag spatial task conduct three experi particip perform judgment tempor interv spatial distanc separ block trial two dot success flash various locat particip judg whether durat distanc dot short long manipul cognit demand spatial task distanc vari across experi high discrimin non demand spatial task experi scarc discrimin demand spatial task experi import manipul tend enhanc perceptu sensit index weber ratio slow decis process index respons time demand experi result provid evid robust space time time space effect experi crucial involv cognit resourc demand spatial task caus massiv time space effect spatial judgment inde influenc irrelev tempor inform revers experi overal flexibl spatiotempor interfer direct theoret implic question origin space time interact | D007600;D013028 | T041 |
36,229,628 | cbct base cross section studi preval anatom featur c shape molar among jordanian preval anatom featur c shape mandibular second molar msms rare studi jordanian sub popul studi took part evalu preval c shape msms use cone beam comput tomographi cbct jordanian sub popul use cross section design three thousand scan collect eight year data review whether fulli form msms total case msms evalu identifi c shape canal coron middl apic site obliqu slice modul perpendicular long axi msms use evalu teeth type frequenc c shape canal well correl sex side rightleft sex groov direct buccallingu measur use chi squar test spss softwar signific level total teeth patient c shape molar compris patient teeth bilater c shape canal mean age year sex ratio femal male limit studi lingual groov type common properti msm besid jordanian popul most c shape canal | D054893;D008334;D008963 | T023;T060;T030 |
36,229,626 | applic modifi weibul extens distribut model censor medic dataset bayesian perspect contribut analyz censor medic dataset use modif convent lifetim distribut howev said contribut consid modif weibul distribut wd wd import lifetim model due prime import model life data mani research propos differ modif wd one recent modif wd modifi weibul extens distribut mwed howev abil mwed model censor medic data yet explor literatur explor suitabl model model censor medic dataset analysi carri use bayesian method differ loss function inform prior approxim bay estim comput use lindley approxim base detail simul studi real life analysi conclud bayesian method perform better compar maximum likelihood estim case small sampl perform bay estim elf inform prior best howev case larg sampl choic prior loss function affect effici result larg extend mwed perform effici model real censor dataset relat surviv time leukemia bile duct cancer patient mwed explor promis candid model model censor medic dataset | D001499 | T081 |
36,229,624 | effect incub temperatur develop morpholog thermal physiolog emerg neotrop lizard model organ tropidurus torquatus incub temperatur among main phenotyp trait variat driver studi sinc development trajectori ovipar anim direct affect environment condit last decad global warm predict arous interest understand impact biodivers predict effect direct warm exacerb anthropogen factor microclimat edg effect although brazilian cerrado biom one affect issu littl known aforement effect biodivers therefor aim studi investig influenc incub temperatur development paramet morpholog thermal physiolog trait collar lizard tropidurus torquatus furthermor discuss find regard lizard development biolog climat chang paradigm therefor incub torquatus egg five temperatur regim rang artifici nest temperatur c c found elev incub temperatur affect sever investig trait egg mass gain posit affect without influenc newborn mass incub period broad reduc temperatur increas surviv rate negat affect temperatur constant c regim confirm lethal incub temperatur sex ratio affect c prevail outbreak femal increas incub temperatur also affect bodi head size effect limb size newborn thermoregul critic thermal maximum ct max affect incub temperatur hand basal bodi temperatur bb critic thermal minimum ct min posit affect thermal physiolog also affect age newborn differ adult analyz thermal trait find indic futur modif incub temperatur regim nest site caus warm may affect sever featur develop morpholog thermal physiolog newborn speci laboratori experi point possibl drastic effect warm lizard surviv rate also affect aspect natur histori popul distribut moreov addit vulner adult aspect predat feed torquatus newborn also vulner regard thermal physiolog trait | D008116 | T014 |
36,229,622 | overview sampl host guest bind challeng sampl seri challeng aim focus communiti specif model challeng test hope drive progress comput method help guid pharmaceut drug discoveri studi report result sampl host guest blind challeng predict absolut bind affin sampl focus two host guest dataset one involv cucurbituril cb seri common drug abus anoth involv two differ gibb deep caviti cavitand latter dataset involv previous featur deep caviti cavitand temoa well new variant teetoa bind seri relat rigid fragment like guest challeng particip employ reason wide varieti method though mani base molecular simul predict accuraci mix previous sampl iter sampl sampl found one approach achiev greater accuraci appli empir correct bind free energi predict take advantag prior data bind host anoth approach perform well hybrid md base approach reweight forc match qm potenti cavitand challeng alchem method use amoeba polariz forc field achiev best success rmse less kcalmol anoth alchem approach atmgaff ambcctipphrem rmse less kcalmol work discuss also highlight sever import lesson exampl retrospect studi refer calcul demonstr sensit predict bind free energi ethyl group sampl andor guest start pose provid guidanc help improv futur studi system | D056004;D011506 | T044;T066;T116;T123 |
36,229,621 | ladderan isoster meta substitut aromat ring rigidifi cyclohexan aromat ring isoster rigidifi satur hydrocarbon import motif enabl drug discoveri herein disclos ladderan class meta substitut aromat ring isoster rigidifi cyclohexan straightforward synthesi build block present along repres derivat preliminari studi reveal ladderan offer similar metabol physicochem properti thus establish class molecul interest motif | D003510 | T109 |
36,229,620 | phenocam observ flower anomali rhododendron arboreum sm himalaya climat chang impact perspect flower exhibit signific relationship environment stimuli chang effect photoperiod vernal well studi flower phenolog howev effect soil temperatur flower less explor one major factor veget growth alpin ecosystem studi thus focus effect soil air temperatur flower respons rhododendron arboreum sm himalayan tree speci also indic spring initi high altitud region monitor flower pattern employ autom phenocam set masl tungnath indian alpin region uttarakhand time laps photographi timberlin ecoton soil air temperatur record continu timberlin ecoton three year dataset use present studi phenocam observ display interest event year complet absenc flower r arboreum popul tungnath timberlin ecoton soil temperatur data increas winter dec jan floral bud form soil temperatur c accumul freez degre day found year air temperatur howev display relationship failur flower rule aerial chill frost injuri floral bud result possibl relationship soil temperatur flower suggest point toward necessari root apex vernal stimulus shallow root rhododendron howev depend flower rhododendron winter soil temperatur requir continu monitor observ make concret infer | D029793 | T002 |
36,229,619 | co express pd l specif chimer switch receptor augment efficaci persist car cell via cd cd axi co express chimer switch receptor csrs specif pd l improv antitumor effect chimer antigen receptor car cell howev effect tran recognit csrs pd l express activ car cell remain unclear design csr specif pd l carp contain transmembran cytoplasm signal domain cd cd chain show carp cell enhanc antitumor activ anti mesothelin car carmz cell vitro vivo addit confoc microscopi indic pd l molecul carmz cell accumul cell cell contact carp cell use singl cell rna sequenc analysi reveal carp cell promot carmz cell differenti central memori like cell upregul gene relat th cell downregul th associ cytokin cd cd axi moreov effect restrict pd l car cell express anti cd csr exhibit similar effect anti psca car cell truncat cd express find suggest target tran recognit csrs car cell may improv efficaci persist car cell via cd cd axi | D018106;D000076962 | T192;T116;T129 |
36,229,618 | enhanc adsorpt congo red dye onto polyethyleneimin impregn biochar deriv pine needl biochar deriv wast pine needl chemic modifi use polyethyleneimin pei increas adsorpt potenti withdraw anion dye congo red aqueous solut pei impregn biochar confirm scan electron microscopi energi dispers x ray analysi fourier transform infrar spectroscopi x ray diffract analysi surfac area biochar decreas pei treatment amin group increas biochar surfac pei treat biochar display consider increas adsorpt acid condit adsorpt isotherm best explain langmuir model r adsorpt kinet agre well pseudo second order model maximum adsorpt capac pei treat biochar observ mg g mg g pristin biochar display fold increas posit valu standard enthalpi adsorpt h kjmole indic endotherm natur adsorpt posit valu entropi jmole k reveal affin biochar toward dye molecul negat valu gibb free energi g kjmole reveal process spontan electrostat interact appear key mechan govern adsorpt process thus pei impregn biochar repres novel low cost sorbent effect remov anion dye poor remov pristin biochar | D028223;D014874 | T131;T002 |
36,229,616 | traceless cystein linchpin enabl precis engin lysin nativ protein mainten machineri requir oper understand toolbox repair method precis engin nativ protein meet similar requir biosystem success hing principl regul chemic reaction protein report technolog deliv high level control reactiv chemoselect site select modular dual probe instal protein select util cystein base chemoselect linchpin direct site select modif lysin residu protein ldm c k effici end user friend protocol evid quantit convers within hour chemic orthogon c bond format bond dissoci essenti among multipl regulatori attribut method offer protein select target singl lysin residu singl protein complex biomolecular mixtur protocol render analyt pure singl site probe engin protein bioconjug also provid access homogen antibodi conjug afc adc ldm c k adc exhibit high select anti prolif activ toward breast cancer cell | D003545;D018796 | T121;T123;T116;T129 |
36,229,614 | predict comput platform optim design bioartifici pancrea devic deliveri encapsul islet stem cell deriv insulin produc cell ie bioartifici pancrea devic may achiev function cure type diabet efficaci limit mass transport constraint model constraint thus desir previous effort invok simplif limit util insight herein present comput platform investig therapeut capac generic user programm bioartifici pancrea devic account high influenti stochast properti includ size distribut random local cell first appli platform studi find endogen islet size distribut varianc signific influenc devic potenc pursu optim determin ideal devic structur estim curat cell dose final propos new devic specif islet equival convers tabl develop surrog machin learn model host web applic rapid produc coeffici user defin devic | D003922;D061385;D007515;D016381 | T121;T061;T047;T023 |
36,229,613 | tgf depend lymphoid tissu resid stem like cell limit respons tumor vaccin tgf signal necessari cd cell differenti tissu resid memori cell rm although higher frequenc cd rm cell tumor microenviron associ better prognosi tgf blockad typic improv rather worsen outcom show mous melanoma model tumor drain lymph node tdln rather tumor stem like cd cell differenti rm tgf tumor antigen depend manner follow vaccin melanoma specif epitop tumour specif cd cell maintain stem like state proport cell lost rm status differenti cxcr effector cd cell tdln subsequ migrat tumour disrupt tgf signal chang dynam development process net result improv effector cd cell migrat tumour summari tdln stem like cell transient switch tgf depend rm differenti program anti tumor migratori effector develop upon vaccin transit facilit target tgf blockad | D016915;D019496;D007252;D007396;D008545;D053918;D022261;D018449 | T116;T121;T191;T065;T109;T129;T097 |
36,229,608 | detail behavior videograph neural dataset object recognit mice mice adept use whisker touch recogn learn object environ behavior enabl comput perform popul neuron somatosensori cortex understand comput train mice use whisker recogn differ shape record activ barrel cortex process whisker input present larg dataset high speed video whisker along rigor track entir extent multipl whisker everi contact made shape use spike sort identifi individu neuron respond precis time whisker contact motion data use understand behavior strategi mice use explor object well neuron dynam mediat strategi addit care curat label data could use develop new comput vision algorithm track bodi postur extract respons individu neuron larg scale neural record | D013003;D014738 | T023;T029 |
36,229,606 | metabol communic tumour immun microenviron metabol hostil tumour microenviron impos barrier tumour infiltr immun cell imped durabl clinic remiss follow immunotherapi metabol communic cancer cell neighbour immun cell could determin amplitud type immun respons highlight potenti involv metabol crosstalk immun surveil escap review explor tumour immun metabol crosstalk discuss potenti nutrient limit strategi favour anti tumour immun respons | D059016;D009369 | T191;T070 |
36,229,605 | algal photosystem dimer high resolut model psi plastocyanin complex photosystem psi enabl photo electron transfer regul photosynthesi bioenerget membran cyanobacteria chloroplast multi subunit complex macromolecular organ affect dynam photosynthet membran reveal chloroplast psi green alga chlamydomona reinhardtii organ homodim compris protein subunit transmembran helic provid scaffold pigment cryogen electron microscopi identifi absenc psah lhca give rise head head relat orient psi light harvest complex monom way essenti differ oligom format cyanobacteria light harvest protein lhca key element mediat dimer interfac monom lack psah thus partial overlap surfac area would bind one light harvest complex ii complex state transit also defin accur avail psi light harvest complex model resolut includ flexibl bound electron donor plastocyanin assign correct ident orient pigment well water molecul affect energi transfer pathway | D045331;D000458 | T007;T026;T126;T116 |
36,229,594 | ddx coordin rna splice transcript elong prevent dna replic stress hematopoiet cell myeloid malign ddx mutat often associ bone marrow failur cytopenia overt diseas manifest howev mechan under specif condit remain elus demonstr loss ddx function impair effici rna splice result dna replic stress excess r loop format mechanist ddx bind splice site ss code rna coordin rna splice transcript elong loss ddx prevent splice coupl transient paus rna polymeras ii ss caus aberr r loop format transcript replic collis although degre dna replic stress acquir phase small cell undergo mitosi replic dna remain result micronuclei format signific dna damag thus lead impair cell prolifer genom instabl process may respons diseas phenotyp associ ddx mutat | D012326;D022821 | T045;T086 |
36,229,592 | innov diagnosi gastrointestin neuroendocrin neoplasm use wax physisorpt kinet base ftir imag neuroendocrin neoplasm nen common gastrointestin gi tract tumor divid neuroendocrin tumor net neuroendocrin carcinoma nec accord mitosi ki index howev object discord interobserv may caus unsuit diagnosi mislead treatment nowaday aberr glycosyl glycoconjug induc popul elong complex oligosaccharid coval attach glycoconjug anchor cell membran neo synthesi cancer associ alter carbohydr determin observ cancer develop studi aim demonstr wax physisorpt kinet coupl fourier transform infrar wpk ftir imag net nec rectum colon stomach util two wax reagent beeswax paraplast glycan adsorb physic bind glycan glycoconjug base dipol induc dipol interact result show greater physisorpt beeswax paraplast suggest high popul elong glycan glycoconjug adher onto tumor surfac net adjac benign mucosa rectum colon besid wpk result gastric nen tissu section show higher infrar absorb ratio beeswax remnant paraplast remnant remain onto tissu section refer higher popul elong glycan gastric net compar gastric nec base find differ anatom locat could share similar phenomena minor varianc conclus wpk ftir imag may potenti employ altern diagnost method gi nen futur | D018278;D005770;D007414;D018358;D010190;D013274 | T191 |
36,229,591 | singl cell transcriptom analys reveal distinct gene express signatur sever covid presenc clonal hematopoiesi clonal hematopoiesi indetermin potenti chip common age relat process predispos individu various inflammatori respons report associ covid sever howev immunolog signatur exact gene express program presenc chip exert clinic impact covid remain elucid studi generat singl cell transcriptom landscap sever covid accord presenc chip use peripher blood mononuclear cell patient chip exhibit potent ifn respons exacerb inflamm particular classic monocyt compar patient without chip dissect regulatori mechan chip specif ifn respons gene express sever covid identifi dnmta chip mutat depend differenti methyl region dmrs annot putat target gene base long rang chromatin interact reveal chip mutant driven hypo dmrs pois cis regulatori element appear facilit chip specif ifn mediat inflammatori immun respons result highlight presenc chip may increas suscept hyperinflamm reorgan chromatin architectur establish novel subgroup sever covid patient | D000082182;D000086382 | T047;T067;T033 |
36,229,590 | transcript regul chromatin dynam dna doubl strand break eukaryot cell dna damag occur time chromatin locus includ loci activ transcript take place dna doubl strand break affect chromatin integr elicit dna damag respons facilit repair dna lesion activ transcrib gene near dna lesion transient suppress crosstalk dna damag respons factor polycomb repress complex epigenet modul chromatin environ also contribut effici dna damag respons signal transcript repress hand rna transcript produc g phase well activ chromatin context lesion appear drive homolog recombin repair discuss iswi famili chromatin remodel factor coordin dna damag respons transcript repress especi transcript activ region highlight direct modul epigenet environ | D002843;D053903 | T116;T049 |
36,229,584 | associ chang pancreat morpholog vascular complic subject type diabet mellitus retrospect studi decreas pancreat volum increas pancreat fat mass serrat pancreat margin characterist morpholog chang pancrea subject type diabet mellitus retrospect studi aim clarifi clinic signific pancreat morpholog chang subject type diabet mellitus underw abdomin magnet reson imag mean age hbac valu year old respect pancreat bodi mass correct bodi surfac area bsa subject diabet mellitus lower compar normal glucos toler cm vs cm although reach statist signific negat correl bsa correct pancreat volum age durat diabet glycoalbumin mean max imt posit correl bsa correct pancreat volum homa serrat pancreat limbus often observ subject diabet mellitus compar normal glucos toler vs subject serrat chang older higher hbac viscer fat area signific larger subject serrat chang bsa correct pancreat volum subject serrat chang signific smaller mean imt signific thicker subject serrul furthermor advanc diabet retinopathi diabet nephropathi often observ subject serrat chang taken togeth decreas bsa correct pancreat volum serrat chang associ progress vascular complic subject type diabet mellitus | D002318;D003924 | T047 |
36,229,581 | advanc clinic translat research germ cell tumour gct recommend malign germ cell intern consortium germ cell tumour gcts heterogen group rare neoplasm present differ anatom site across wide spectrum patient age birth adulthood strata appli cohort number becom modest hinder infer regard manag therapeut advanc moreov patient gcts treat differ medic profession includ paediatr oncologist neuro oncologist medic oncologist neurosurgeon gynaecolog oncologist surgeon urologist silo care thus form hamper knowledg dissemin specialist dedic biobank specimen collect therefor critic foster continu growth understand similar differ age gender site particular rare cancer gcts malign germ cell intern consortium provid framework creat sustain global research infrastructur facilit acquisit tissu liquid biopsi togeth match clinic data set reflect divers gcts effort would creat invalu repositori clinic biolog data underpin intern collabor span profession boundari translat clinic practic ultim impact patient outcom | D009373;D013736 | T191 |
36,229,577 | antiretrovir therapi resist mutat among hiv infect peopl kazakhstan kazakhstan number peopl live hiv plhiv increas steadili sinc develop antiretrovir therapi art resist mutat artrm major hurdl achiev effect treatment prevent hiv use hiv pol sequenc plhiv kazakhstan analyz artrm associ factor may promot develop artrm plhiv infect hiv subtyp crfag artrm qk associ increas viral load decreas cd cell count infect crfag associ lower likelihood qk interest crfag posit associ artrm lv turn observ frequent darunavir administr infect crfag posit associ artrm sa turn frequent observ administr nevirapin also associ lower cd count zidovudin nevirapin receipt associ develop artrm ea turn associ lower cd count determin patient hiv variant help guid art choic kazakhstan exampl plhiv infect crfag benefit less darunavir nevirapin emtricitabin replac zidovudin | D019380;D015658;D015497 | T121;T047;T005 |
36,229,571 | machin learn enabl nir spectroscopi assess powder blend uniform clear dispar bias induc physic artefact nir spectroscopi non destruct character tool blend uniform bu assess howev nir spectra powder blend often contain overlap physic chemic inform sampl deconvolut inform relat chemic properti associ physic effect one major object work achiev aim two way first identifi various sourc variabl might affect bu result second leverag machin learn base sophist data analyt process accomplish aforement object calibr sampl amlodipin activ pharmaceut ingredi api concentr rang ww dose ww powder blend contain excipi prepar use gravimetr approach assess use nir spectroscop analysi follow hplc measur bias nir result investig employ data qualiti metric dqm bias varianc decomposit bvd overcom bias cluster regress non parametr linear appli assess model perform employ hold k fold intern cross valid cv nir base blend homogen low mean absolut error interv estim mean standard deviat ww establish addit bootstrap base cv leverag part nir method lifecycl manag demonstr mean absolut error mae bu ww bu ww model generaliz model transfer respect workflow integr machin learn nir spectral analysi establish implement impact various data learn approach nir spectral data | D005079;D019265 | T059;T120;T122 |
36,229,569 | clinic impact lymphocytec reactiv protein ratio postop outcom patient rectal cancer underw curat resect cancer relat system inflamm influenc postop outcom cancer patient although relationship inflamm relat marker postop outcom investig mani studi clinic signific remain elucid rectal cancer patient focus lymphocyt countc reactiv protein ratio lcr use predict short long term outcom rectal cancer surgeri patient rectal cancer underw curat resect institut enrol studi comprehens compar effect inflamm relat marker includ lcr clinicopatholog characterist predict postop complic surviv receiv oper characterist curv analysi indic lcr highest area curv valu predict occurr postop complic multivari analysi male sex odd ratio confid interv ci p low tumor locat ci p low lcr ci p signific independ associ occurr postop complic addit multivari analysi use cox proport hazard regress model predict surviv show low lcr signific associ poor overal surviv hazard ratio hr ci p recurr free surviv hr ci p lcr use marker predict short long term postop outcom rectal cancer patient underw curat surgeri | D002097;D012004 | T191;T116;T129 |
36,229,567 | chang deep vasculatur assess use anterior segment oct angiographi follow trabecular meshwork target minim invas glaucoma surgeri effect trabecular meshwork tm target minim invas glaucoma surgeri mig vasculatur assess use anterior segment optic coher tomographi angiographi octa establish prospect longitudin studi investig chang deep vasculatur follow tm target mig use octa open angl glaucoma patient octa imag sclera conjunctiva nasal corneal limbus acquir preoper month postop vessel densiti vds superfici conjunctiv deep intrascler layer calcul vds mig compar factor associ chang vd follow mig analyz mean deep vd decreas baselin postop p superfici vd chang p multivari stepwis regress analysi reveal deep vd reduct direct associ iop reduct p preoper iop p invers associ preoper deep vd p deep vd reduct follow mig signific success group eye p unsuccess group eye p deep vds assess use octa decreas follow tm target mig especi eye good surgic outcom | D005901;D005902 | T047 |
36,229,566 | requir sampl intens communiti analys intertid infauna detect mechan disturb coastal ecosystem infaun anim live within sediment invertebr use studi monitor disturb howev open question minim requir sampl intens detect disturb influenc communiti implement manipul experi use infaun communiti known respons communiti composit popul abund mechan disturb sediment scour determin minimum sampl intens requir detect differ infaun communiti statist signific differ infaun communiti disturb refer replic observ case studi consist sampl per sampl per sampl per treatment sampl known statist biolog differ undetect howev least sampl per treatment sampl per requir observ infaun communiti within similar accur assess infaun communiti find suggest studi attempt identifi disturb may requir minim sampl intens equival sampl per studi attempt determin infaun communiti vari disturb may requir sampl per potenti minim requir sampl intens use theoret explor disturb well appli conserv restor monitor project | D017753;D004784 | T082;T057;T070 |
36,229,565 | effect qualiti improv strategi implement specif visual tool promot icu earli mobil earli progress mobil safe strategi intens care unit icu howev still consid challeng inher barrier poor adher earli mobil protocol aim studi evalu effect qualiti improv qi multifacet strategi implement specif visual tool mobil clock reduc non complianc institut earli mobil em protocol adult icus singl center qi retrospect comparison studi conduct use data medic record hospit electron databas patient differ period present similar baselin characterist qi strategi declin non complianc protocol observ compar previous period vs p proport patient walk signific higher vs p icu readmiss rate lower period vs p multifacet strategi specif design consid institut barrier effect increas bed mobil reduc non complianc rate protocol achiev higher level mobil adult icus tertiari hospit | D004434;D058996 | T061;T057 |
36,229,564 | nutrient organ pollut remov synthet wastewat pseudomona aeruginosa chryseobacterium spbiofilt system nutrient organ pollut rais serious problem aquat ecosystem accumul organ carbon reduct light penetr loss submerg aquat veget enrich water nitrogen phosphorus lead imbal nutrient ratio creat favor condit toxic algal bloom format oxygen deplet water etc thus develop new technolog solut reduc amount imper present studi investig capac pseudomona aeruginosa chryseobacterium sp bacteri strain form biofilm solid support biofilt individu tandem use various analyt techniqu also biofilmbiofilt system effici remov nutrient nitrat nitrit ammonium phosphat ion municip wastewat assess result show reduct nutrient pollut nitrit nitrat ammonium phosphat ion reduct cod also observ result obtain absenc addit aerat process thus great potenti reduc total cost wastewat treatment develop ecolog system wastewat manag | D064751;D045247;D004785 | T007;T104;T131;T197 |
36,229,563 | multipl type program necrosi necroptosi pyroptosi oxytosisferroptosi parthanato contribut simultan retin damag ischemia reperfus ischemia reperfus ir injuri implic larg array patholog condit retina increas experiment evid suggest program necrosi make signific contribut inflamm retin damag trigger ir sinc mani type program necrosi import identifi involv retin ir determin correct treatment end use mous model retin ir varieti approach includ rna seq data analysi rna seq data reveal rapid develop ischem patholog retina first h reperfus found least four type program necrosi includ necroptosi pyroptosi oxytosisferroptosi parthanato simultan involv retin ir data suggest high activ tnf pathway earli stage retin ir lead earli activ necroptosi signific activ type program necrosi appear later result indic tnf glutam ferrous iron generat steap may key player concurr trigger least necroptosi oxytosisferroptosi parthanato ischem retin ganglion cell rgcs thus multipl signal cascad involv program necrosi synchron target therapeut purpos treat retin ir | D000079403;D000079323;D015427;D012164 | T043;T047;T037 |
36,229,560 | combin ngn program dopaminerg pattern rapid effici generat hipsc deriv midbrain neuron use human deriv induc pluripot stem cell hipsc differenti dopaminerg da neuron offer valuabl experiment model decort cellular molecular mechan parkinson diseas pd pathogenesi howev exist approach present sever limit notabl lengthi time cours protocol high variabl yield da neuron report develop improv approach combin neurogenin program use commerci avail midbrain differenti kit rapid effici reproduc direct differenti hipsc matur function induc da ida neuron minimum contamin brain cell type gene express analysi associ function character examin neurotransmitt releas electr record support function ident ida neuron midbrain neuron ida neuron show select vulner expos hydroxydopamin thus provid viabl vitro approach model pd screen small molecul neuroprotect proprieti | D057026;D010300 | T025;T047 |
36,229,556 | eae rapid guidelin updat systemat review network meta analysi cinema grade assess evid inform european recommend manag common bile duct stone choledocholithiasi present consider proport patient gallbladd diseas sever manag option includ preoper intraop endoscop cholangiopancreatographi ercp laparoscop common bile duct explor lcbde | D017081;D042883;D042882 | T061;T047;T031 |
36,229,549 | use baidu index understand chines interest thyroid relat diseas common thyroid diseas hyperthyroid hypothyroid thyroid thyroid tumor baidu current wide use onlin search tool china develop internet search trend collect analysi tool call baidu index aim present studi understand trend characterist public onlin attent thyroid diseas explor valu baidu index monitor onlin retriev behavior thyroid relat inform take period januari decemb time rang consider use big data analysi tool baidu index took thyroid nodul thyroid cancer thyroid hyperthyroid hypothyroid keyword data search index media index record week basi inform aggreg quarter annual generat final data carri secondari analysi pearson correl analysi use analyz correl search index keyword year one way analysi varianc use analyz differ search index media index among five keyword thyroid nodul search index highest growth rate follow thyroid cancer media attent thyroid diseas declin year year unlik public attent media index hyperthyroid signific higher keyword past nine year public attent thyroid relat diseas increas gradual baidu index effect tool track health inform queri behavior chines internet user provid cost effect supplement tradit monitor system | D009369;D013959 | T191;T047 |
36,229,548 | probe pattern microbi consortia cellular automaton spatial organis microbi consortia exhibit spatial pattern across divers environ sinc probe self organ natur microbi communiti limit inher complex synthet model emerg attract altern studi develop novel framework bacteri communic explor emerg spatiotempor organ microb specif built quorum sens mediat model microbi growth util character dynam communiti arbitrari initi configur establish effect communic strategi coupl growth rate microb simul indic behavior quorum sens coupl consortia effect modul rate secret acyl homoserin lacton mechan control enabl construct desir relat popul constitu speci spatial organ popul model accur recapitul previous experi investig pattern format synthet multi cellular system addit softwar tool enabl easi implement analysi framework varieti initi configur simplifi develop sophist gene circuit facilit distribut comput overal demonstr potenti spatial organ tunabl paramet synthet biolog introduc communic paradigm base locat strength coupl microbi strain | D054742;D059013 | T001;T109 |
36,229,546 | quorum sens control matrix protein product drive fractal wrinkl interfaci local vibrio cholera pellicl bacteri cell fluid interfac self assembl collect communiti stun macroscop morpholog within soft live materi call pellicl constitu cell gain group level surviv advantag includ increas antibiot resist howev regulatori structur compon drive pellicl self pattern well defin use vibrio cholera model system report two set matrix protein key quorum sens regul joint orchestr sequenti mechan instabl under pellicl morphogenesi culmin fractal pattern pair matrix protein rbmc bap maintain pellicl local interfac prevent self peel singl matrix protein rbma drive morphogenesi program mark cascad ever finer wrinkl fractal scale wavelength artifici express rbma restor fractal wrinkl rbma mutant enabl precis tune fractal dimens quorum sens regulatori small rnas qrr first activ matrix synthesi launch pellicl primari wrinkl ridg instabl subsequ via distinct mechan qrr suppress fractal wrinkl promot fine modul pellicl morpholog result connect cell cell signal architectur compon morphogen pattern suggest manipul quorum sens regul synthet control rbma express could underpin strategi engin soft biomateri morpholog demand | D014734 | T007 |
36,229,545 | genom centric analysi short long read metagenom reveal uncharacter microbiom divers southeast asian despit extens effort address vast uncharacter dark matter microbi genet divers impact short read sequenc base metagenom studi popul specif bias genom refer databas compound problem leverag advanc hybrid assembl use short long read hi c technolog cross section survey deepli character gut microbiom three ethnic singapor comprehens reconstruct medium high qualiti metagenom assembl genom miss short read analysi n improv speci level cluster identifi total novel gut speci improv refer genom speci total discov strain uniqu popul among top abund gut bacteria studi one speci strain unrepres exist databas annot biosynthet gene cluster bgcs uncov bgcs larg fraction unrepres current databas sever uniqu cluster predict produc bacteriocin could signific alter microbiom communiti structur result reveal signific uncharacter gut microbi divers southeast asian popul highlight util hybrid metagenom refer bioprospect diseas focus studi | D001430;D064307 | T116;T028;T001;T123;T032 |
36,229,544 | optic map compendium structur variant across global cattl breed structur variant sv link import bovin diseas phenotyp due difficulti accur detect standard sequenc approach role shape import trait across cattl breed larg unexplor optic map altern approach map svs shown higher sensit dna sequenc approach aim project use optic map develop high qualiti databas structur variat across cattl breed differ geograph region enabl studi svs cattl generat x bionano optic map data cattl nine differ ancestri three contin cattl sub speci total identifi svs putat overlap code region resourc provid high qualiti set optic map base sv call use across studi valid dna sequenc base sv call prioritis candid function variant genet associ studi expand understand role svs cattl evolut | D002417;D023281 | T015;T091 |
36,229,543 | wildfir disproportion affect jaguar pantan pantan wetland harbour second largest popul jaguar world alongsid climat land use chang recent mega fire pantan may pose threat jaguar long term surviv put grow threat perspect address reach intens fire affect jaguar conserv pantan ecoregion last year fire sever annual seri burn pantan affect estim jaguar popul brazil home rang area protect area within home rang fire consum core habitat injur sever jaguar pantan apex predat displac hunger dehydr territori defenc lower fecund among impact may affect abund speci impact like affect less mobil speci therefor ecolog stabil region solut prevent recurr mega fire lie combat anthropogen caus intensifi drought condit implement action protect spring increas number area protect area regul fire use alloc fire brigad dri season | D046009;D000075923 | T015;T070 |
36,229,540 | impact lifestyl environment factor male reproduct health identif potenti environment hazard clinic relev diagnosi male infertil knowledg factor improv prevent fertil disord apart drug factor relat lifestyl alcohol tobacco smoke various environment occup agent chemic physic may impair male reproduct reproduct toxic may evolv hypothalam pituitari testicular posttesticular level endpoint compris deterior spermatogenesi sperm function well endocrin disord sexual dysfunct howev due complex regul male reproduct system inform regard singl exogen factor mechan action human limit also due fact extrapol result obtain experiment anim vitro studi remain difficult nevertheless assess relev exposur reproduct toxic care evalu diagnost procedur androlog patient | D060728;D007248 | T047;T091;T184;T033 |
36,229,519 | immedi protein express exogen mrnas embryon brain mrna vaccin sar cov wide use save million peopl world effici protein produc exogen mrnas embryon brain howev less known show protein express occur high effici neural stem cell narrow time window mrna electropor embryon mous brain plasmid success transfect protein express detect h h electropor mrnas plasmid respect deliveri exogen mrnas may use vaccin also function analysi brain | D000086382;D000086663 | T047;T200;T067 |
36,229,517 | integr network base multipl comput analys identif co express candid gene associ neurolog manifest covid tripartit network tn combin gene network cgn construct hub bottleneck driver node gene evalu target gene tg identifi candid gene cg relationship neurolog manifest covid tn develop use neurolog symptom covid found literatur queri gene tg tn co express gene identifi use pair wise mutual inform gene avail rna seq autopsi data frontal cortex covid victim cgn construct gene select tn co express covid tg connect gene respect network underw function analys find enrich term pair wise semant similar score sss new integr weight harmon mean score formul assimil valu sss string base combin score select tg pair provid cg pair properti cgs co express indispens node cgn final six pair share seven preval cgs adam adam akt ctnnb esr pikca fgfr show linkag phenotyp direct neurodegener neurodevelopment diseas tumourcanc cellular signal b indirect cgs behaviouralcognit motor dysfunct pathophysiolog preval cgs discuss interpret neurolog phenotyp covid | D000086382;D009369 | T191;T047;T067 |
36,229,516 | ultrafast laser filament induc fluoresc detect uranium stress chlamydomona reinhardtii plant photosynthet organ suggest potenti pervas biosensor nuclear nonprolifer monitor demonstr ultrafast laser filament induc fluoresc chlorophyl green alga chlamydomona reinhardtii promis method remot field detect stress exposur nuclear materi method hold advantag broad area surveil solar induc fluoresc monitor target excit specif plant would improv detect exampl local biota densiti low expos c reinhardtii uranium find concentr chlorophyl chlorophyl fluoresc lifetim carotenoid content increas increas fluoresc lifetim signifi decreas non photochem quench simultan increas carotenoid content impli oxid stress confirm product radic oxygen speci evid steadi state absorpt spectrum potenti uniqu signatur uranium previous work find heavi metal stress general increas non photochem quench identifi tempor profil chlorophyl fluoresc distinguish featur uranium expos unexpos alga discrimin uranium expos sampl possibl distanc formula see text singl laser shot modest collect system determin combin experi simul distanc scale uncertainti discrimin tempor profil illustr potenti remot detect detect would requir laser shot commensur detect time order | D016825;D014501 | T196;T204 |
36,229,515 | modif swcnts hybrid materi zno ag zno au enhanc bactericid activ phagocyt cell escherichia coli nox pathway zinc oxid silver zno ag zinc oxid gold zno au nano composit prepar wet chemic process lace singl wall carbon nanotub swcnts yield zno ag swcnts zno au swcnts hybrid nano composit lace swcnts hybrid character use raman spectroscop x ray diffract xrd scan electron microscopi sem transmiss electron microscopi tem analys hybrid evalu effect phagocyt cell bactericid activ gram negat bacteria e coli phagocyt cell activ intracellular kill action found signific increas zno ag swcnts zno au swcnts nano hybrid induc widespread clearanc escherichia coli increas product reactiv oxygen speci ros also led upregul phagocytosi determin mechanist involv phagocyt nadph oxidas nox pathway find emphas role zno ag zno au decor swcnts prevent bacteri infect inhibit biofilm format show potenti util cathet coat clinic | D037742;D015034 | T121;T104;T073;T197 |
36,229,514 | pax loss function delay tumour progress kras induc zebrafish rhabdomyosarcoma model rhabdomyosarcoma soft tissu cancer aris skelet muscl due mutat myogen progenitor lead ineffect differenti malign transform transcript factor pax pax downstream target gene tight link fusion posit alveolar subtyp wherea ras pathway usual involv embryon fusion negat variant analys role pax fusion negat context link alter gene express paxapaxb doubl mutant zebrafish tumour progress kras induc rhabdomyosarcoma tumour sever gene rasmapk signal pathway signific regul paxapaxb doubl mutant zebrafish progress rhabdomyosarcoma tumour also delay paxapaxb doubl mutant zebrafish indic pax transcript factor unappreci role mediat malign fusion negat rhabdomyosarcoma | D012208;D018233 | T191 |
36,229,511 | protein deliveri live cell thermal stimul biophys investig studi biomolecul nativ environ repres ideal sampl condit structur biolog investig present novel protocol allow deliveri protein eukaryot cell mild thermal stimul data present herein show efficaci approach deliv protein intracellular environ mammalian cell reach concentr rang suitabl success appli biophys method doubl electron electron reson deer measur characteris protein conform | D005057;D011506 | T025;T123;T116 |
36,229,510 | de novo yc missens variant na v imped pore region result epilept encephalopathi epilepsi common neurolog disord character recurr unprovok seizur scna encod na v neuron voltag gate na channel high express throughout central nervous system na v local within axon initi segment play critic role initi propag action potenti neuron fire predomin amino butyr acid gaba ergic neuron hippocampus object studi character de novo missens variant uncertain signific scna gene proband present febril status epilepticus character general tonic clonic movement associ ictal emesi abnorm breath pattern screen gene panel reveal heterozyg missens variant uncertain signific scna gene design ca g p tyrci na v wild type wt mutant channel reproduc vivo transfect hek cell na current record use whole cell configur patch clamp techniqu na v variant tyrci fail express function na current express hek cell probabl due pore defect channel given cell surfac express channel normal current generat co transfect function wt channel exhibit biophys properti compar wt channel main due function wt channel cell surfac na v variant fail express function na current probabl due pore impair exhibit well establish loss function mechan present studi highlight ad valu function test understand pathophysiolog potenti treatment decis patient undiagnos development epilept encephalopathi | D004827;D004829 | T047;T033 |
36,229,507 | compar analysi sar cov viral load across differ altitud sar cov spread throughout world includ area locat high high altitud debat role high altitud hypoxia viral transmiss incid covid relat mortal first comparison sar cov viral load across elev rang describ sar cov viral load across sampl come citi locat low moder high high altitud ecuador observ analysi viral load among nasopharyng swap sampl come cohort patient rt qpcr test posit sar cov relationship high low altitud consid sampl person equal case signif p valu case low altitud ad sex variabl analysi possibl find signif differ men women p valu consid initi sex altitud possibl find signif differ high low altitud men p valu enough evid state viral load affect direct altitud rang ad new variabl sex analysi show presenc new variabl influenc relationship altitud rang viral load evid viral load ct copiesml differ low high altitud use sex co factor found men higher viral load women low moder altitud locat live high altitud differ found ct valu aggreg low moder high viral load found signific differ sex exclud analysi conclud viral load direct affect altitud covid incid mortal rather affect socio demograph idiosyncrat dynam | D000086382;D000086402 | T047;T067;T005 |
36,229,504 | assess variabl plasma k somascan proteom assay somascan high throughput aptam base proteom assay design simultan measur thousand protein broad rang endogen concentr current version k somascan assay v capabl measur human protein work present extens technic assess platform base studi sampl across plate includ studi design inter plate technic duplic human subject allow us character differ normal procedur evalu assay variabl multipl analyt approach present signal background metric discuss potenti specif issu provid detail perform assess wide rang technic aspect aim work serv valuabl resourc grow communiti somascan user | D040901 | T091 |
36,229,503 | longitudin bioluminesc imag monitor breast tumor growth treatment respons use chick chorioallanto membran model develop success treatment regimen breast cancer requir strong pre clinic data generat physiolog relev pre clinic model report develop chick embryo chorioallanto membran cam model studi tumor growth angiogenesi use breast cancer cell line mda mb mcf tumor cell line engraft onto chick embryo cam studi tumor growth treatment respons tumor growth evalu bioluminesc imag signific increas tumor size vascular found day period evalu impact anti angiogen drug axitinib bevacizumab tumor growth angiogenesi drug treatment signific reduc tumor vascular size overal find demonstr chick embryo cam clinic relev model monitor therapeut respons breast cancer use platform drug screen evalu gross chang tumor burden physiolog process angiogenesi | D001943;D049033 | T191;T018 |
36,229,502 | deep residu neural network base robot joint fault diagnosi method data driven method base robot joint fault diagnosi method use deep residu neural network drnn propos resnet base fault diagnosi method introduc propos method main deal kind fault type gain error offset error malfunct sensor actuat respect first deep residu network fault diagnosi model deriv stack small convolut core increas core size meanwhil gaussian white nois inject fault data set verifi nois immun propos deep residu network furthermor simul conduct differ fault diagnosi method includ support vector machin svm artifici neural network ann convolut neural network cnn long term memori network ltmn deep residu neural network drnn compar simul result show accuraci fault diagnosi robot system use drnn higher meanwhil drnn need less model train time visual analysi prove feasibl effect propos method robot joint sensor actuat fault diagnosi use drnn method | D012371 | T090 |
36,229,501 | effect odor sleep qualiti healthi particip present studi aim systemat examin whether laurin orang odor specif design perfum influenc sleep qualiti sleep healthi particip n present odor odor nose clip fourteen consecut night phase one collect physiolog paramet togeth subject report later longer last effect manipul examin follow fourteen night phase two without exposit odor addit olfactori cognit non cognit measur conduct phase one phase phase two one way analys varianc repeat measur night condit vs within subject factor odor condit togeth odor pleasant rate subject factor employ analys data overal present result demonstr odor condit comparison control consist effect sleep healthi particip possibl explain exposur odor via nose clip howev analys indic individu pleasant odor enhanc posit assess sleep qualiti altogeth present result indic subject percept odor hedon valu appear crucial sleep qualiti odor | D009812;D000089943 | T033;T120;T070 |
36,229,500 | develop valid machin learn earli mortal system sclerosi clinic predictor mortal system sclerosi ssc divers report due differ healthcar condit popul simpl predict model earli mortal among patient ssc need precis referr tool general practition aim develop valid simpl predict model predict mortal among patient ssc prognost research histor cohort studi design conduct januari decemb adult ssc patient attend scleroderma clinic univers hospit thailand data extract scleroderma registri databas earli mortal defin die within year onset ssc deep learn algorithm adam optim differ machin learn algorithm includ logist regress decis tree adaboost random forest gradient boost xgboost autoencod neural network use classifi ssc mortal addit model perform evalu use area receiv oper characterist curv auroc confid interv ci valu confus matrix predict model develop includ ssc patient femal dcssc nineti five die within year diseas onset final model highest predict perform compris modifi rodnan skin score mrss fc ii model mrss fc iii model model provid highest predict perform follow model intern valid accuraci auroc good specif high model model vs model simplifi machin learn model predict earli mortal among patient ssc could guid earli referr specialist help rheumatologist close monitor manag plan extern valid across multi ssc clinic consid studi | D045743;D012595 | T047 |
36,229,499 | bioelectr imped analysi estim one repetit maximum measur muscl strength leg press healthi young adult resist train rt progress determin individu muscl strength measur one repetit maximum rm howev evalu time consum safeti concern bioelectr imped analysi bia valid easi use method assess skelet muscl mass smm although bia measur often correl muscl strength studi rm rt bia measur avail observ studi examin relationship rm bia measur develop bia base predict model rm thirti five healthi young japanes adult includ smm skelet muscl mass index smi measur use bia devic addit domin leg rm measur use unilater leg press lp machin correl bia measur rm calcul simpl regress analys perform predict rm bia variabl result show signific correl rm domin leg smm r p smi r p predict model rm lp deriv smm domin leg smi x p r x p r respect result indic bia base smi might use predict rm lp accur | D007866;D055070 | T061;T023 |
36,229,498 | hydrodynam analysi magnet field depend viscous fluid flow thermosolut convect rotat channel accord research expos person magnet field enhanc blood flow minim risk suffer heart attack ferrohydrodynam studi fluid motion mechan affect strong magnet polaris forc fhd ferrofluid may transmit heat varieti way use magnet fluid behaviour demonstr liquid cool speaker utilis less ferrofluid prevent heat reach speaker coil modif boost coil abil expand enabl loudspeak creat high fidel sound investig fluid dynam spin squeez plate affect thermosolut convect magnet field depend mfd viscos standard differenti equat use repres equat modifi form navier stoke maxwel thermosolut convect magnet field modifi veloc field equat thermosolut convect equat yield suitabl answer addit comput thorough detail mhd torqu fluid pressur impart top plate creat techniqu quick certain converg result equat uniform plate solv use homotopi analysi method ham appropri start estim auxiliari paramet valid reliabl ham outcom shown compar ham solut bvpc numer solver programm found magnet reynold number lower temperatur fluid well tangenti axial compon veloc field addit fluid mfd viscos rise axial azimuth compon magnet field behav opposit one anoth studi applic develop new aircraft take gear magnetorheolog airbag automobil heat cool system bio prosthet biosensor system | D018481;D057446 | T070 |
36,229,497 | epidemiolog clinic featur therapeut intervent outcom mucormycosi shiraz year retrospect case studi comparison children adult mucormycosi invas fungal infect high morbid mortal rate despit earli diagnosi proper therapeut intervent given import epidemiolog data review attitud toward infecti diseas develop countri current retrospect case studi aim compar epidemiolog aspect risk factor clinic characterist therapeut intervent outcom mucormycosi adult children eight year main infecti diseas referr center southwest iran median age patient includ studi year iqr median length hospit daysth annual incid mucormycosi relat hospit estim per admiss studi period moreov incid infect time higher male femal children diabet mellitus frequent predispos factor adult main risk factor children hematolog malign consider proport immunocompetentth frequent antifung agent use liposom amphotericin b monotherapi combin therapi use adult children addit surgic intervent antifung therapi consid effect therapeut approach hospit mortal rate adult wherea zero children find provid recent epidemiolog analysi mucormycosi among hospit patient children adult mucormycosi main affect individu diabet mellitus hematolog malign present rhino orbito cerebr form proven diagnosi mucormycosi accord clinic manifest histopatholog observ accompani proper antifung treatment may improv surviv rate | D003920;D019337;D009091 | T191;T047 |
36,229,496 | clone silico character abiot stress induc u box domain contain protein gene gspub glycin soja ubiquitin pathway involv posttransl modif cellular protein howev role e ubiquitin ligas famili protein abiot stress condit remain unclear particular soybean core object current studi isol function character gspub protein gene wild soybean glycin soja use homolog clone method investig abiot stress respons gspub da molecular weight protein amino acid residu sequenc align reveal presenc u box domain phylogenet analysi show abund pub protein monocot dicot plant analysi gene structur predict absenc intron along presenc one exon furthermor activ gspub protein anticip plasma membran express persuad nacl aba peg nahco treatment consider higher manifest root leav although express veget reproduct part g soja gspub protein show sequenc ident u box domain contain protein arabidopsi thaliana oryza sativa subsp japonica respect gspub exhibit relat higher express salin drought stress particular root wherea model gspub protein generat use swiss model studi use manipul gspub protein gspub gene transform purpos function character abiot stress condit | D017360;D018506 | T045;T002 |
36,229,495 | earli dynam chronic myeloid leukemia nilotinib predict deep molecular respons chronic myeloid leukemia cml myeloprolif disord caus bcr abl tyrosin kinas although abl specif tyrosin kinas inhibitor tkis includ nilotinib dramat improv prognosi patient cml tki efficaci depend individu patient work found patient differ nilotinib respons classifi use estim paramet simpl dynam model two common laboratori find furthermor propos method identifi patient fail achiev treatment goal high fidel accord data collect three initi time point nilotinib therapi sinc model reli general properti tki respons framework would applic cml patient receiv frontlin nilotinib tkis | D015464;D047428 | T191;T116;T121 |
36,229,494 | structur studi phosphoribosyltransferas involv cobamid biosynthesi methanogen archaea cyanobacteria cobamid cbas coenzym use cell across domain life de novo synthesi found bacteria archaea five enzym assembl nucleotid loop alpha phase corrin ring condens activ ring nucleobas yield adenosyl cba phosphat upon dephosphoryl yield biolog activ coenzym adocba base activ catalyz phosphoribosyltransferas prtase structur salmonella enterica prtase enzym ie secobt well character archaeal prtase gain insight mechan base activ prtase methanocaldococcus jannaschii mjcobt solv crystal structur enzym complex substrat product determin sever structur structur mjcobt absenc ligand apo ii structur mjcobt bound nicotin mononucleotid namn ribazol phosphat rp adenylyl phosphat amp respect mjcobt general base trigger reaction aspart residu asp rather glutam residu e secobt notabl dimer interfac mjcobt complet differ observ secobt final entri pdb lz reflect correct structur mjcobt | D000458;D019605 | T007;T194 |
36,229,493 | synerget synchron oscil distribut neural integr induc dynam equilibrium energi dissip system synchron phenomenon common mani natur mechan system joint friction damp human anim associ energi dissip coupl oscil model convent use manag multipl joint torqu generat form limit cycl energi dissip system coupl term design frequenc phase set becom issu select oscil model relat coupl relationship oscil need predefin unknown dynam system quit challeng problem present simpl distribut neural integr method induc limit cycl unknown energi dissip system without use coupl oscil result demonstr synerget synchron oscil could produc adapt differ physic environ find balanc energi inject neural input form dynam equilibrium trivial problem dynam inform prior known propos method realiz self organ pattern generat induc dynam equilibrium differ mechan system oscil manag without use explicit phase frequenc knowledg howev phase frequenc amplitud modul emerg form effici synchron limit cycl type distribut neural integr use sourc regul multi joint coordin induc synerget oscil natur mechan system | D004594 | T091 |
36,229,492 | effect passiv solar dri food secur rural mozambiqu achiev food secur mozambiqu critic sinc popul afford adequ diet increas agricultur product necessari effort address challeng inadequ post harvest treatment lead storag loss qualiti degrad repercuss food secur use solar dri promot solut provid effici reliabl access food preserv improv food secur situat rural communiti howev lack clear evid use access solar dri affect food secur studi identifi determin farmer choic use solar dri evalu effect passiv solar dryer food secur use survey data household alloc solar dryer select communiti interest individu belong communiti elig use propens score match endogen switch poisson regress use estim averag effect use solar dri associ train signific increas food secur status particip increas household food avail women dietari divers month adequ household food provis decreas household food insecur access scale | D005523;D012424 | T098;T081;T102 |
36,229,490 | new oblig cxcl cxcl heterodim studi chemokin heterodim activ mechan chemokin form famili protein critic role mani biolog process health diseas condit includ cardiovascular autoimmun diseas infect cancer mani chemokin engag heterophil interact form heterodim lead synergist activ enhanc reduct depend natur heterodim form chemokin mixtur differ chemokin speci divers activ coexist dynam equilibrium lead observ combin respons biolog assay overcom problem produc non dissoci cxcl cxcl chemokin heterodim ohd new tool studi biolog activ mechan chemokin heterodim biolog environ use ohd show cxcl cxcl chemokin heterodim inhibit cxcl driven migrat tripl negat mda mb breast cancer cell also show cxcl cxcl chemokin heterodim bind activ cxcr receptor | D054377;D019718 | T192;T123;T116;T129 |
36,229,489 | birdsong allevi anxieti paranoia healthi particip present studi investig effect urban traffic nois vs natur birdsong soundscap mood state paranoia cognit perform hypothes birdsong lead signific improv outcom addit goal explor differenti impact lower vs higher divers soundscap manipul number differ typic traffic sound song differ bird speci within respect soundscap random onlin experi n particip expos one four condit min traffic nois low traffic nois high birdsong low birdsong high divers soundscap exposur particip perform digit span dual n back task fill depress anxieti paranoia questionnair traffic nois soundscap associ signific increas depress small effect size low medium effect size high divers condit concern birdsong condit depress exclus decreas exposur high divers soundscap small effect size anxieti paranoia signific decreas birdsong condit medium effect size cognit effect observ sum present studi suggest listen birdsong regardless divers improv anxieti traffic nois also regardless divers relat higher depress moreov first time benefici medium size effect birdsong soundscap demonstr reduc paranoia overal result bear interest implic research activ manipul soundscap differ environ set eg psychiatr ward test effect subclin even clinic manifest anxieti paranoia | D010259;D013016 | T048;T070 |
36,229,488 | sporozoit motil quantit readout anti csp antibodi inhibit antibodi prevent malaria neutral infecti plasmodium falciparum sporozoit spz establish infect liver circumsporozoit protein csp abund surfac protein spz lead candid passiv subunit immun approach malaria comprehens assess parasit inhibitori capac anti csp monoclon antibodi mab import step advanc csp base immun strategi studi employ quantit imag base motil assay quantifi effect anti csp mab spz motil vitro human skinour assay provid quantit measur mab parasit inhibitori capac measur half maxim motil inhibitori concentr ic valu anti csp mab ic nm ic sp nm found sevenfold discrep ic bind satur concentr measur elisa possibl relat observ shed csp mab complex spz movement subset spz vitro motil unaffect presenc sp abl complet block movement ex vivo skin explant model spz prove less suscept anti csp mab compar spz vitro environ quantit assess motil creat valuabl tool use comprehens assess anti csp mab potenc insight help deepen understand anti csp mab potenc guid select promis anti csp mab downstream clinic develop | D008288;D017780;D016778 | T121;T047;T129 |
36,229,487 | optineurin link hace depend rac ubiquityl integrin mediat mechanotransduct control bacteri invas cell divis extracellular matrix ecm elast perceiv cell via focal adhes structur transduc mechan cue chemic signal conform cell behavior although contribut ecm complianc control cell migrat divis extens studi littl report regard infecti process studi phenomenon extraintestin escherichia coli pathogen uti show uti take advantag via cnf toxin integrin mechanoactiv trigger invas cell identifi hace e ligas interact protein optineurin optn protein regul ecm stiff function analysi establish role optn bacteri invas integrin mechan coupl stimul hace e ligas activ toward rac gtpase consist role optn cell mechan optn knockdown cell display defect integrin mediat traction forc buildup associ limit cellular invas uti nevertheless optn knockdown cell display strong mechanochem adhes signal enhanc rac activ increas cyclin translat togeth enhanc cell prolifer independ ecm stiff togeth data ascrib new function optn mechanobiolog | D019938;D016023 | T192;T123;T116;T129 |
36,229,485 | whole farm plan rais profit despit burgeon climat crisi climat crisi challeng farmer livelihood increas frequent extrem weather event impact quantum consist crop product develop novel paradigm rais whole farm profit optimis manifold variabl drive profit irrig grain farm build invok new decis support tool watercan profit optimis crop type area collect maximis farm profit showcas four region across climat gradient australian crop zone principl develop appli crop region product system anywher world show number profit crop type fell futur climat reflect interplay commod price yield crop water requir variabl cost effect climat chang profit relat long term rainfal futur climat depress profit relat histor climat impact futur climat close relat crop type matur durat inde mani crop type tradit profit histor climat longer profit futur demonstr strateg whole farm plan crop type area yield signific econom benefit suggest futur work drought adapt consid genet select criteria divers phenolog yield alon crop type higher valu per unit grain weight lower water requir higher water use effici like ensur sustain prosper irrig grain product system futur climat | D057231;D055864 | T070 |
36,229,484 | intermitt hypoxia inhibit epinephrin induc transcript chang human aortic endotheli cell obstruct sleep apnea osa independ risk factor cardiovascular diseas intermitt hypoxia ih catecholamin releas play import role increas risk mechan incomplet understood recent report ih caus endotheli cell ec activ earli phenomenon develop cardiovascular diseas via ih induc catecholamin releas investig effect ih epinephrin gene express human aortic ec use rna sequenc found signific overlap ih epinephrin induc differenti express gene deg includ enrich leukocyt migrat cytokin cytokin receptor interact cell adhes angiogenesi epinephrin caus higher number deg compar ih interest ih combin epinephrin inhibitori effect epinephrin induc gene express combin ih epinephrin induc mtg metallothionein g shown high express ec part aorta ie aortic arch atherosclerosi like occur conclus epinephrin greater effect ih ec gene express term number gene express level ih inhibit epinephrin induc transcript respons investig interact ih epinephrin need better understand osa caus cardiovascular diseas | D002318;D020181 | T047 |
36,229,482 | loss stabil unfold cooper hpgk upon gradual structur perturb n termin domain hydrophob core phosphoglycer kinas model stabil fold cooper catalysi two domain protein human isoform hpgk associ cancer develop rare genet diseas affect sever featur investig mutat affect hpgk fold landscap interact network introduc mutat buri site n termin domain f mutant either creat caviti fl fv fa enhanc conform entropi fg introduc structur strain fw evalu effect use biophys experiment theoret method f mutant fold well show reduc unfold cooper kinet stabil alter activ energet accord result thermal chemic denatur analys alter correl well structur perturb caus mutat n termin domain destabil caus interdomain interfac reveal hd exchang nativ condit import experiment theoret analys show effect signific even perturb mild local approach use establish molecular basi hpgk genotyp phenotyp correl due phosphoryl event singl amino acid substitut associ diseas | D017510 | T044 |
36,229,481 | hippo pathway link adipocyt plastic adipos tissu fibrosi fibrosi disrupt adipos tissu homeostasi exacerb metabol dysfunct upon chronic calor excess molecular mechan link adipocyt plastic fibrosi larg unknown show hippo pathway coupl tgf signal orchestr cellular andor function shift adipocyt energi storag extracellular matrix ecm remodel fibrosi found lat knockout adipocyt could dedifferenti dpp progenitor cell convert dpp myofibroblast upon tgf stimul hand hippo pathway inhibit obes impair adipocyt ident promot ecm remodel activ adipocyt macrophag recruit ccl produc tgf acceler fibrosi yap taz hippo downstream effector enhanc smad stabil promot fibrot respons import inhibit yaptaz activ obes mice mark reliev fibrosi improv metabol homeostasi togeth find identifi hippo pathway molecular switch initi develop fibrosi impli therapeut target | D048868;D000090683 | T043;T123;T116 |
36,229,480 | obes relat measur success age among communiti dwell older adult india cross section studi obes chief lifestyl diseas global caus signific increas morbid overweight obes preval rise faster india compar world averag therefor studi examin associ overweight obes success age among older popul india also explor gender differ risk pose obes success age differ socio econom correl associ success age studi util data india first nation repres longitudin age survey lasi effect sampl size present studi older adult mean age year sd overweight obes defin bodi mass index studi carri bivari analysi observ associ depend independ variabl multivari analysi conduct examin associ control individu socio demograph lifestyl householdcommun relat factor studi includ men women found preval obesityoverweight higher among older women compar older men vs similar high risk waist circumfer vs high risk waist hip ratio vs preval among older women older men studi found signific gender differ men women preval rate success age p chanc success age signific higher among older adult obeseoverweight aor ci high risk waist circumfer aor ci high risk waist hip ratio aor ci compar respect counterpart interact result reveal older women obeseoverweight lower likelihood success age compar older men obeseoverweight aor ci similar older women high risk waist circumfer aor ci high risk hip ratio aor ci less like success age compar counterpart respect overweight obes high risk waist circumfer waist hip ratio found signific factor associ less success age among older adult especi women studi current find highlight import understand modifi factor includ nutrit awar develop target strategi promot success age | D057187;D050177 | T056;T033 |
36,229,479 | health state util patient hepat b c hepat relat condit japan health state util global measur qualiti life use evalu health outcom cost util analysi studi aim estim health state util patient hepat b hb hepat c hc hepat relat diseas japan distribut self administ questionnair includ euroqol dimens level eq l outpati sever clinic condit caus hb hc virus infect asymptomat chronic hepat chronic hepat compens cirrhosi decompens cirrhosi estim condit specif util patient hb hc patient sever condit patient acut hepat fulmin hepat hepatocellular carcinoma patient undergo post liver transplant util sever condit estim three hepat expert use eq l mean util acut hepat fulmin hepat asymptomat chronic hepat chronic hepat compens cirrhosi compens cirrhosi hepatocellular carcinoma stage iii hepatocellular carcinoma stage iiiiv post liver transplant hb hc respect best knowledg first studi comprehens assess health state util patient hb hc hepat relat condit nationwid survey japan use eq l | D006528;D006506;D006509;D006526;D008113;D047508 | T191;T047;T046 |
36,229,478 | exposur air pollut effect ischem stroke ep particl studi well known exceed level particul matter air air pollut harm affect cardiovascular system empir analys effect factor stroke incid mortal still limit main object analys determin associ short term exposur air pollut stroke incid non industri area specif north eastern poland achiev aim use data nation health fund patient hospit stroke largest citi region describ green lung poland pollut level atmospher condit data obtain provinci inspector environment protect institut meteorolog water manag use daili data hospit atmospher condit pollut well order logist regress model hypothes impact weather air pollut condit ischem stroke test studi group includ patient male averag patient age approxim year averag concentr pm gm pm gm co gm analys show increas pm pm concentr gm associ increas incid stroke day exposur ci p ci p effect even sever time greater occurr stroke event general pm ci p pm ci p furthermor short term day effect co stroke incid observ studi area increas gm co associ lower incid stroke day exposur ci p higher incid day exposur ci p | D000393;D000397;D000083242 | T069;T047;T131;T080 |
36,229,476 | age visual percept object size experi evalu abil younger older adult visual judg object size three condit full cue dark linear perspect complet dark observ made repeat judgment squar stimuli task adjust separ match perceiv size squar enabl evalu precis well accuraci judgment accur dark linear perspect condit full cue condit indic linear perspect serv import sourc optic inform support percept object size contrast complet dark linear perspect inform unavail accuraci observ judgment poor final differ either accuraci precis observ judgment two age group despit fact older adult year older younger adult mean age younger older adult year respect abil visual perceiv object size well maintain increas age unlik number import visual abil | D007600;D014796 | T041 |
36,229,475 | first direct evid adult european eel migrat breed place sargasso sea european eel anguilla anguilla critic endang accord recent iucn assess suffer declin recruit sinc attribut part factor occur marin phase life cycl adult european eel undertak longest spawn migrat anguillid eel distanc km across atlant ocean sargasso sea howev despit passag almost year sinc johann schmidt propos sargasso sea breed place european eel basi larval survey egg spawn adult ever sampl confirm fundament question therefor remain ocean migrat adult eel includ navig mechan rout taken time arriv swim speed spawn locat attach satellit tag eel river azor archipelago track period day speed km day provid first direct evid adult european eel reach presum breed place sargasso sea | D000811 | T013 |
36,229,474 | emot prosodi recognit enhanc progress complexifi childhood adolesc emot prosodi result dynam variat languag acoust non verbal aspect allow peopl convey recogn emot goal paper understand recognit develop childhood adolesc also aim investig abil perceiv multipl emot voic matur time test children adolesc age year old expos kind linguist meaningless emot anger fear happi sad neutral stimuli particip ask judg type intens perceiv emot continu scale without forc choic task predict general linear mix model analysi reveal signific interact effect age emot abil recogn emot signific increas age emot neutral vocal girl recogn anger better boy instead confus fear neutral prosodi girl across age margin signific differ found anger happi neutral compar sad difficult recogn final age increas particip signific like attribut multipl emot emot prosodi show represent emot content becom increas complex abil identifi basic emot prosodi linguist meaningless stimuli develop childhood adolesc interest matur evidenc accuraci emot detect also complexif emot attribut prosodi | D004644;D014831 | T041;T040 |
36,229,473 | optim linear estim model predict year overlap homo sapien neandert prior disappear franc northern spain recent fossil discoveri suggest neandert homo sapien may co exist europ long year yet evid contemporan region scale remain high elus franc northern spain region featur latest direct date neandert europ protoaurignacian assemblag attribut homo sapien appear replac neandert associ chtelperronian assemblag use earliest latest known occurr start point bayesian model provid indic occup may fact part contemporan realiti howev unlik ever identifi first last appear speci cultur tradit archaeolog fossil record use optim linear estim model estim first appear date homo sapien extinct date neandert franc northern spain statist infer miss portion protoaurignacian chtelperronian archaeolog record addit estim extinct date neandert region use dataset direct date neandert fossil remain total dataset consist sixti six modern produc radiocarbon determin recalibr use newest calibr curv intcal produc updat age rang result suggest onset homo sapien occup region like preced extinct neandert chtelperronian year reaffirm bayesian deriv durat co exist group initi upper palaeolith region use novel independ method indic understand time occup may suffer substanti gap record whether co exist featur form direct interact howev remain resolv | D015186;D059125 | T015 |
36,229,472 | allochthon materi origin saprolit marker termit activ ferralsol ferralsol estim cover million km worldwid deepli weather red yellow soil found humid tropic consid end geochem sequenc weather domin low activ clay sesquioxid physic properti close relat strong submillimetr granular structur aim character clay miner identifi mani ferralsol discuss marker soil feed termit activ ferralsol present result record brazilian ferralsol develop cerrado nativ veget rang parent materi found miner vari weak weather muscovit hydroxi al interlay vermiculit sometim associ fine materi chemic composit high differ groundmass surround submillimetr granular aggreg result show miner associ fine materi consid allochthon materi origin saprolit brought ferralsol soil feed termit activ confirm major role termit properti ferralsol rais question possibl consequ land use chang usual deepli affect soil biodivers | D020049;D012990 | T131;T204 |
36,229,470 | sever underweight affect develop nontubercul mycobacteri pulmonari diseas nationwid longitudin studi regard known associ underweight non tubercul mycobacteri pulmonari diseas ntm pd underweight simpli categor bodi mass index bmi less kgm main low preval aim better defin impact bmi sever ntm pd develop analys health data individu examin follow decemb determin incid ntm pd base bmi kgm popul categor mild moder sever underweight group use cox proport hazard analys hazard ratio ntm pd calcul accord sever underweight refer normal bmi median follow year particip develop ntm pd risk ntm pd increas signific sever underweight multivari adjust hazard ratio confid interv mild moder sever underweight respect subgroup analysi younger year old male exacerb effect sever underweight risk ntm pd studi prove underweight categori becam sever risk ntm pd increas proport | D008171;D009165 | T047 |
36,229,469 | spatiotempor variat retrovirus host interact among darwin finch endogen retrovirus erv inherit remnant retrovirus colon host germlin million year provid sampl retrovir divers across time util strength darwin finch system synonym evolutionari studi investig erv histori reveal recent retrovirus host interact natur popul map erv variat across speci darwin finch compar outgroup speci highlight geograph histor pattern retrovirus host occurr util system evalu extent time retrovir activ host undergo adapt radiat colon new environ find share erv among sampl indic retrovirus host associ pre date host speciat well consider erv variat across popul entir darwin finch radiat unexpect erv variat finch speci differ island suggest histor chang gene flow select non random distribut erv along chromosom across finch speci suggest associ erv accumul rapid speciat darwin finch | D020077;D046369;D046109 | T012;T005 |
36,229,468 | low function vulner fish assemblag coral loss southwestern atlant margin reef margin reef sustain coral assemblag condit consid suboptim coral result low coral abund reef inhabit numer fish general unknown degre associ coral might lead assumpt coral play minor role determin fish occurr coral could actual sustain divers resili assemblag use site occup model fit data reef fish speci differ life stage adult juvenil reef distribut across southwestern atlant first assess fish assemblag respons coral turf algal cover identifi coral associ fish simul loss coral associ fish contrast random loss provid infer resili fish assemblag function trait space speci loss entir fish assemblag respond posit coral turf alga speci identifi coral associ fish simul loss coral associ fish reduc function trait space differ random loss result reveal margin reef southwestern atlant reef host resili fish assemblag might preserv fundament ecolog function ecosystem servic even coral declin | D037421 | T204 |
36,229,467 | coemiss luminesc nanoparticl combin aggreg induc emiss quench dye prepar continu flow achiev ideal light harvest system low cost remain challeng herein report synthesi hybrid dye system base tetraphenylen tpe encapsul organ dye continu flow microreactor composit dye nanoparticl nps synthes base supramolecular self assembl achiev co emiss aggreg induc emiss dye aggreg caus quench dye ceaa numer simul molecular spectroscopi use investig synthesi mechan ceaa dye nanoparticl ceaa dye provid platform effici cascad frster reson energi transfer fret composit dye nanoparticl tpe nile red nir synthes ideal light harvest system use coumarin c energi intermedi light harvest system consider red shift distanc nm high energi transfer effici et antenna effect final versatil prepar method divers ceaa dye demonstr | D005456;D053758 | T073;T130 |
36,229,465 | nonlinear germanium silicon photodiod activ monitor photon neuromorph network silicon photon promis artifici neural network comput owe superior interconnect bandwidth low energi consumpt scalabl fabric howev lack silicon integr monitor optic neuron limit revolut larg scale artifici neural network highlight nonlinear germanium silicon photodiod construct chip optic neuron self monitor optic neural network specif engin optic optic optic electr respons propos neuron merg optic activ non intrus monitor function compact footprint experiment scalabl three layer photon neural network enabl situ train learn object classif semant segment task perform neuron implement deep scale neural network confirm via handwrit recognit achiev high accuraci believ work enabl futur larg scale photon intellig processor function simplifi architectur | D005857;D012825 | T196 |
36,229,464 | singl cell analysi cribriform prostat cancer reveal cell intrins tumor microenvironment pathway aggress diseas cribriform prostat cancer found invas cribriform carcinoma icc intraduct carcinoma idc aggress histolog subtyp associ progress lethal diseas delin molecular cellular underpin iccidc aggress studi examin pair iccidc benign prostat surgic sampl singl cell rna sequenc tcr sequenc histolog iccidc cancer cell express gene associ metastasi target potenti therapeut intervent pathway analys ligandreceptor status model cellular interact among iccidc tumor microenviron tme includ jagnotch iccidc tme hallmark increas angiogenesi immunosuppress fibroblast cthrc aspn fap eng along fewer cell elev cell dysfunct increas cqb trem apo macrophag find support cancer cell intrins pathway complex immunosuppress tme contribut aggress phenotyp iccidc data highlight potenti therapeut opportun restor immun signal patient iccidc may afford better outcom | D002285;D011471 | T191 |
36,229,463 | med novel bind partner brca regul homolog recombin r loop process homolog recombin hr major repair pathway dna doubl strand break close relat carcinogenesi hr defici establish therapeut target aim studi elucid function novel hr factor mediat complex subunit med associ brca format medbrca complex examin immunoprecipit gst pull assay transcript cofactor role brca evalu use luciferas assay role med dna damag respons hr analyz immunofluoresc hr assay r loop accumul analyz use immunofluoresc r loop induc dna damag analyz comet assay immunoprecipit gst pull assay demonstr med novel bind partner brca bind brct domain luciferas assay show med potenti transcript abil brct two fold med deplet cell recruit hr gene rpa hax dna damag site sever impair hr assay show med knockdown signific decreas hr activ r loop nuclear accumul r loop induc comet tail observ med deplet cell conclud transcript factor med contribut regul hr pathway r loop process | D056913;D000080870 | T123;T116;T114 |
36,229,462 | brain de novo transcriptom assembl toad speci show polymorph anti predatori behavior understand genom underpin antipredatori behavior hot topic eco evolutionari research yellow belli toad genus bombina textbook exampl deimat display time structur behavior aim startl predat generat first de novo brain transcriptom apennin yellow belli toad bombina pachypus speci show inter individu variat deimat display rna seq experi set individu show distinct behavior phenotyp generat read assembl annot high qualiti assembl confirm assembl valid align contig de novo transcriptom map percentag higher homolog annot diamond blastx led contig annot nr swiss prot trembl wherea domain site protein predict made interproscan led go annot kegg annot contig b pachypus transcriptom describ valuabl resourc studi genom underpin behavior variat amphibian | D059014;D059467 | T059;T081;T063;T086 |
36,229,459 | chronic intak high dietari sucros induc sexual dimorph metabol adapt mous liver adipos tissu almost effect treatment non alcohol fatti liver diseas nafld involv reduct adipos suggest metabol axi liver adipos tissu essenti nafld develop sinc excess dietari sugar intak may initi factor nafld character metabol effect liquid sucros intak concentr relev typic human consumpt mice report sucros intak induc sexual dimorph effect liver adipos tissu microbiom differ concord steatosi sever show steatosi decoupl impair insulin respons sex moder factor influenc sucros driven lipid storag contribut de novo fatti acid synthesi overal hepat triglycerid pool find provid physiolog insight sex influenc regul adipos liver crosstalk highlight import extrahepat metabol pathogenesi diet induc steatosi nafld | D065626 | T047 |
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