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36,229,458
associ serum vitamin incid diabet african american popul incid diabet risk invers proport hydroxyvitamin oh level among non hispan white unclear among african american aa popul serum oh may import compon total oh among aa popul due higher level melanin
D001741;D003920
T098;T047
36,229,456
c mpl del c mpl altern splice isoform promot amkl progress chemoresist acut megakaryocyt leukemia amkl clinic heterogen subtyp acut myeloid leukemia character unrestrict megakaryoblast prolifer poor prognosi thrombopoietin receptor c mpl primari regul megakaryopoeisi potent mitogen receptor aberr c mpl signal implic myriad myeloid prolif disord lead amkl howev role c mpl amkl progress remain larg unexplor identifi increas express c mpl altern splice isoform c mpl del amkl patient found c mpl del express associ enhanc amkl cell prolifer chemoresist decreas surviv xenograft mice c mpl del knockdown attenu prolifer restor apoptosi interest observ c mpl del exhibit preferenti util phosphoryl c mpl del c terminus bias activ pikakt pathway culmin upregul gata downregul ddit relat apoptot respons conduc amkl chemoresist prolifer thus studi elucid critic role c mpl altern splice amkl progress drug resist may import diagnost therapeut implic leukemia acceler c mpl del overexpress
D007947;D053628
T191;T116;T192
36,229,455
guidanc landscap unveil quantit proteom control reinnerv adult visual system injur adult central nervous system cns activ pro growth molecular pathway neuron lead long distanc regener howev regen fiber display guidanc defect prevent reinnerv function recoveri therefor molecular character proper target region regen axon essenti uncov modal adult reinnerv studi use mass spectrometri ms base quantit proteom address proteom major nuclei adult visual system analys reveal guidanc associ molecul express adult visual target moreov show bilater optic nerv injuri modul express specif protein contrast express guidanc molecul remain steadi final show regen axon abl respond guidanc cue ex vivo suggest molecul possibl interfer brain target reinnerv adult use long distanc regener model demonstr silenc specif guidanc signal lead rerout regen axon vivo altogeth result suggest way modul axon guidanc regen neuron achiev circuit repair adult
D009416;D020221
T043;T042;T037
36,229,454
reduc akt retin pigment epitheli cell caus compensatori increas akt attenu diabet retinopathi retin pigment epithelium rpe play import role develop diabet retinopathi dr lead caus blind worldwid set explor role akt signal integr rpe homeostasi glucos metabol dr use human tissu genet manipul mice includ rpe specif condit knockout cko knock ki mice investig whether akt rpe influenc dr model diabet eye diseas found akt akt activ reciproc regul rpe dr donor tissu diabet mice akt cko attenu diabet induc retin abnorm compensatori upregul phospho akt lead inhibit vascular injuri inflammatori cytokin releas infiltr immun cell mediat gsknf b signal pathway overexpress akt effect propos target akt activ rpe may novel therapi treat dr
D003921;D003930
T050;T047
36,229,453
addict mental disord call standard definit dual disord persist difficulti conceptu relationship addict mental disord stand among mani challeng face field psychiatri differ philosophi school thought sheer complex high preval clinic condit make progress inher difficult mention profus compet sometim contradictori term unnecessarili exacerb challeng lack standard term add confus fuel stigma contribut wrong door syndrom captur difficulti diagnos also treat addict mental disord integr manner world associ dual disord wadd propos adopt term dual disord still arbitrari would help harmon various clinic research effort ralli around singl accur less stigmat design
D016739;D001523;D011570;D019966
T091;T097;T048;T033
36,229,452
deglaci forest conundrum fast northern hemispher nh forest biom track strong warm climat larg unknown region studi reveal lag decad millennia report conundrum deglaci forest expans nh extra tropic occur approxim year earlier transient mpi esm simul shown pollen base biom reconstruct shortcom model reconstruct could contribut mismatch leav under caus unresolv simul veget respond within decad simul climat chang agre pollen independ reconstruct thus exclud climat bias main driver differ instead mismatch point multi millenni disequilibrium nh forest biom climat signal therefor evalu time slice simul strong chang climat pollen record critic reassess result impli nh forest may respond much slower ongo climat chang earth system model predict
D057231;D065928
T070
36,229,451
posteriori dietari pattern insulin resist diabet risk hispaniclatino heritag hchssol cohort examin link among dietari pattern dps insulin resist ir diabet risk heritag hispan communiti health studystudi latino
D003920;D007333
T047;T046
36,229,450
real time holograph lensless micro endoscopi flexibl fiber via fiber bundl distal holographi fiber base micro endoscop critic import tool minim invas deep tissu imag howev current micro endoscop perform three dimension imag dynam bent fiber without use bulki optic element lens scanner distal end increas footprint tissu damag great effort invest develop approach avoid distal bulki optic element howev fundament barrier dynam optic wavefront distort propag flexibl fiber limit current approach near static non flexibl fiber present approach allow holograph bend insensit coher gate micro endoscop imag use commerci avail multi core fiber mcfs achiev ad partial reflect mirror distal fiber tip allow perform low coher full field phase shift holographi demonstr widefield diffract limit reflect imag amplitud phase target dynam bent fiber video rate approach hold potenti label free investig dynam sampl
D006696;D007909;D055096
T060;T073
36,229,449
inhibit mps kinas enhanc taxan efficaci castrat resist prostat cancer androgen ablat therapi standard care newli diagnos prostat cancer pc patient pc relaps hormon therapi refer castrat resist pc crpc often present metastasi mcrpc major caus diseas lethal avail therapi mcrpc includ taxan docetaxel dtx cabazitaxel cbz ala clinic success taxan mcrpc limit high intrins acquir resist therefor remain essenti develop ration design treatment manag therapi resist mcrpc diseas major effect taxan microtubul hyper polymer prolong mitot block due activ spindl assembl checkpoint sac taxan sensit cell eventu inactiv sac exit mitosi mitot catastroph result genom instabl blockad prolifer resist cell remain mitot block upon drug decay resum mitosi prolifer under one resist mechan studi explor possibl forc mitot exit elev taxan efficaci inactiv sac compon mitot checkpoint kinas mpsttk small molecul inhibitor mspi potenti efficaci taxan treatment cell cultur prostaspher set mechanist mps inhibit forc mitot catastroph cell block mitosi taxan androgen receptor ar main driver pc often mutat truncat mcrpc remark mpsi signific potenti cbz cytotox regardless ar status ar wt ar truncat crpc cell overal data demonstr forc mitot exit mps inhibit potenti taxan efficaci given sever mpsi current differ stage clinic trial result point mps new therapeut target potenti efficaci taxan mcrpc patient
D064129;D011944
T191;T116;T192
36,229,448
structur function analysi entv reveal amino acid fragment protect fungal infect fungal pathogen continu challeng due effect antifung rise resist previous work describ inhibit candida albican virul follow exposur amino acid bacteriocin entv secret enterococcus faecali optim entv potenti therapeut better understand antifung featur x ray structur obtain structur consist six alpha helic enclos seventh amino acid helix individu helic test antifung activ use vitro nematod infect assay interest retain antifung antibacteri activ also effect candida auri cryptococcus neoforman reduct amino acid retain full antifung activ excel efficaci observ rodent model c albican oropharyng system venous cathet infect togeth result showcas entv deriv peptid promis candid antifung therapeut develop
D001430;D003455;D009181
T004;T047;T123;T116
36,229,446
anti angptl fld monoclon antibodi treatment amelior podocyt lesion attenu mitochondri damag proteinuria indic kidney diseas caus malfunct podocyt play key role maintain glomerular filtrat angiopoietin like angptl document cell autonom involv podocyt delet angptl podocyt reduc proteinuria adriamycin induc nephropathi develop monoclon antibodi mab angptl investig effect podocyt injuri adr nephropathi mous model puromycin pan induc podocyt damag vitro mab human angptl fld sequenc ef inhibit bind angptl fld integrin treatment ef mab adr nephropathi mice mitig proteinuria led signific declin podocyt apoptosi reactiv oxygen speci ros generat mitochondri fragment pan induc podocyt damag vitro ef mab block anpgplt mediat activ integrin v rac regul mitochondri homeostasi altogeth anti angplt fld mab attenu proteinuria podocyt lesion adr mice model well pan induc podocyt damag part regul mitochondri function studi provid therapeut approach target angptl proteinur kidney diseas
D007674;D050199
T047;T025
36,229,445
activ glucagon like peptid receptor reduc acquisit aggress like behavior male mice aggress complex social behavior provok defens limit resourc includ food mate recent advanc show gut brain hormon ghrelin modul aggress behavior gut brain hormon glucagon like peptid glp reduc food intak sexual behavior potenti role aggress behavior like therefor investig tentat link glp aggress behavior combin preclin human genet associ studi influenc acut repeat inject glp receptor glp r agonist exendin ex aggress behavior assess male mice expos resid intrud paradigm besid possibl mechan particip abil ex reduc aggress behavior evalu associ polymorph glp r gene overt aggress male catss cohort assess male mice repeat acut ex treatment dose depend reduc aggress behavior neurochem western blot studi reveal putat serotonerg noradrenerg signal nucleus accumben specif shell compart may particip interact ex aggress high fat diet hfd impair respons glp various behavior possibl hfd blunt abil ex reduc aggress behavior explor inde level aggress similar vehicl ex treat mice consum hfd human associ polymorph glp r gene overt aggress overal glp signal suppress acquisit aggress behavior via central neurotransmiss addit studi explor link warrant
D054439;D000067757
T116;T125;T192
36,229,442
spatial structur eco evolutionari dynam host pathogen interact render isol popul vulner diseas negat effect pathogen host well document human agricultur system direct evid pathogen driven impact wild host popul scarc mix determin strength pathogen impos select depend spatial structur analyz growth rate across approxim host popul perenni plant time coupl data pathogen presenc absenc find infect decreas growth isol well connect host popul inocul studi reveal isol popul high suscept diseas connect host popul support highest level resist divers regardless diseas histori spatial eco evolutionari model predict non linear cost resist may critic determin pattern overal evolutionari feedback defin ecolog impact diseas spatial structur system host gene flow import diseas histori determin outcom
D005075;D054884
T045;T040
36,229,441
continu biomark monitor singl molecul resolut measur free particl motion need sens technolog continu monitor concentr level critic biomolecul applic patient care fundament biolog research biotechnolog food industri well environ howev fundament difficult develop measur technolog sensit specif also allow monitor broad concentr rang long timespan describ continu biomolecular sens methodolog base free diffus biofunction particl hover sensor surfac method record digit event due singl molecul interact enabl biomark monitor picomolar micromolar concentr without consum reagent demonstr affin base sens methodolog dna base sandwich competit assay antibodi base cortisol assay addit sensor dri facilit storag week maintain sensit forese enabl develop continu monitor sensor applic fundament research studi organ chip monitor patient critic care monitor industri process bioreactor well ecolog system
D015374
T059;T075
36,229,440
emerg microrobot oscil via asymmetri induc order spontan oscil order sever hertz driver mani crucial process natur bacteri swim mammal gait convert static energi input slowli oscil power key autonomi organ across scale howev fabric slow micrometr scale oscil remain major roadblock toward fulli autonom microrobot studi low frequenc oscil emerg collect activ microparticl air liquid interfac hydrogen peroxid drop interact transduc ambient chemic energi period mechan motion board electr current surpris oscil persist larger ensembl size particl modifi reactiv ad intent break permut symmetri explain emerg order discoveri thermodynam mechan asymmetri induc order board power harvest stabilis oscil enabl use electron compon demonstr cyclic synchron drive microrobot arm work highlight new strategi achiev low frequenc oscil microscal pave way futur microrobot autonomi
D006861;D013550
T121;T056;T130;T197
36,229,438
hospitalis mortal risk sar cov variant omicron sub lineag ba compar ba england omicron variant sar cov becam global domin variant earli sub lineag omicron variant ba identifi england januari investig hospitalis mortal risk covid case omicron sub lineag ba n compar ba n larg cohort studi england estim risk hospit attend hospit admiss death use multivari stratifi proport hazard regress model adjust confound ba case lower similar risk death hr ci hospit admiss hr ci hospit attend hr ci find risk sever outcom follow infect ba sar cov slight lower equival ba sub lineag inform public health strategi countri ba spread
D000086382;D000086402
T047;T067;T005
36,229,435
conserv signal compon coordin epiderm pattern cuticl deposit barley face terrestri threat land plant seal aerial surfac lipid rich cuticl breath plant interrupt cuticl adjust epiderm pore call stomata regul gas exchang develop specialis epiderm cell defens hair mechan coordin epiderm featur remain poor understood address studi two loci whose allel variat caus cuticular wax defici misarrang stomata barley identifi under gene cer g hvyda encod yoda like yda mapkkk cer hvbrx solo encod singl brevi radix brx domain protein gene control cuticular integr space ident epiderm cell barley distinct epicuticular wax bloom well stomat pattern elev co condit genet analys reveal epistat modifi relationship hvyda hvbrx solo intim product particip interact pathway link epiderm pattern cuticular properti barley may repres mechan coordin multipl adapt featur land plant epidermi cultiv cereal
D001467
T168;T002
36,229,433
mitochondri network configur influenc sarcomer myosin filament structur striat muscl sustain muscl contract occur interact actin myosin filament within sarcomer requir constant suppli adenosin triphosph atp nearbi mitochondria howev remain unclear differ physic configur sarcomer mitochondria alter energet support contractil function show sarcomer cross section area csa vari along length cell type depend manner reduct z disk csa relat sarcomer center close coordin mitochondri network configur fli mice human find myosin filament near sarcomer peripheri curv relat interior filament greater curvatur filament near mitochondria compar sarcoplasm reticulum final demonstr variabl myosin filament lattic space filament end filament center cell type depend manner data suggest sarcomer structur myofila interact influenc locat orient mitochondria within muscl cell
D054792;D012518
T026;T024
36,229,432
manganes driven coq defici overexposur manganes disrupt cellular energi metabol across speci molecular mechan under manganes toxic remain enigmat report excess cellular manganes select disrupt coenzym q coq biosynthesi result failur mitochondri bioenerget respiratori chain complex remain intact lack coq lipophil electron carrier preclud oxid phosphoryl lead prematur cell organism death molecular level manganes overload caus mismetal proteolyt degrad coq diiron hydroxylas catalyz penultim step coq biosynthesi coq overexpress supplement coq headgroup analog bypass coq function fulli correct electron transport thus restor respir viabil uncov uniqu sensit diiron enzym mismetal defin molecular mechan manganes induc bioenerget failur conserv across speci
D028361;D014451
T121;T047;T109;T123
36,229,431
int variant caus recess development ciliopathi disrupt assembl integr complex oral facial digit ofd syndrom heterogen group congenit disord character malform face oral caviti digit anomali mutat within cilia relat gene identifi caus sever type ofd suggest ofd constitut subgroup development ciliopathi homozygos map exom sequenc two famili variabl ofd type identifi distinct germlin variant int subunit integr complex multiprotein complex associ rna polymeras ii cleav nascent rna modul gene express determin int util c terminus bind integr cleavag modul disrupt identifi germlin variant psl pknfs deplet int disrupt ciliogenesi human cultur cell caus dysregul broad collect ciliari gene accord knockdown xenopus embryo lead motil cilia anomali altogeth show mutat int caus autosom recess ciliopathi reveal key interact compon integr complex
D000072661;D009958
T047;T019
36,229,430
caldesmon control stress fiber forc balanc dynam cross link myosin ii actin tropomyosin filament contractil actomyosin bundl key forc produc mechanosens element muscl non muscl tissu wherea organ muscl myofibril mechan regul contractil relat well establish principl myosin ii activ forc balanc regul non muscl cell remain elus show caldesmon import compon smooth muscl non muscl cell actomyosin bundl elong protein function dynam cross linker myosin ii tropomyosin actin filament deplet caldesmon result aberr later movement myosin ii filament along actin bundl lead irregular myosin distribut within stress fiber manifest defect stress fiber network organ contractil accompani problem cell morphogenesi migrat invas mechanosens result identifi caldesmon critic factor ensur regular myosin ii space within non muscl cell actomyosin bundl reveal stress fiber network control dynam cross link tropomyosin actin myosin filament
D022502;D014335
T026;T123;T116
36,229,429
inf mediat actin filament reorgan confer intrins resili neuron ischem injuri earli ischem brain injuri glutam receptor hyperactiv mediat neuron death via osmot cell swell show ischemia excess nmda receptor activ caus actin rapid extens reorgan within somatodendrit compart normal f actin concentr within dendrit spine howev min bath appli nmda f actin depolymer within spine polymer stabl filament within dendrit shaft soma similar actinif occur experiment ischemia cultur photothrombot stroke mous follow transient nmda incub actinif spontan revers na cl water ca influx spine f actin depolymer necessari individu suffici actinif combin induc activ f actin polymer factor invert formin inf silenc inf render neuron vulner cell death inf overexpress protect ischemia induc dendrit actin reorgan therefor intrins pro surviv respons protect neuron death induc cell edema
D000199;D016202
T121;T123;T116
36,229,408
select aerob oxid alcohol low melt mixtur water use telescop one pot hybrid reaction effici select sustain protocol develop cucl tempotmeda catalyz aerob oxid activ alcohol correspond carbonyl compound use water environment friend low melt mixtur lmm fructos urea reaction medium oxid reaction proceed mild room temperatur c aerob condit carbonyl deriv isol yield within h reaction time use mention lmm potenti applic methodolog demonstr set use telescop one pot two step hybrid transform direct convers primari alcohol either secondari alcohol valuabl nitroalken combin oxid process nucleophil addit promot high polar organometal compound grignard organolithium reagent nitroaldol henri reaction respect
D000438;D009942
T121;T109
36,229,406
discoveri chlorofluoroacetamid base coval inhibitor sever acut respiratori syndrom coronavirus cl proteas coronavirus diseas covid pandem necessit develop antivir agent sever acut respiratori syndrom coronavirus sar cov c like proteas cl pro promis target covid treatment report new class coval inhibitor cl pro possess chlorofluoroacetamid cfa cystein reactiv warhead base aza peptid scaffold synthes seri cfa deriv enantiopur form evalu biochem effici data reveal yh r configur cfa unit strong block sar cov replic infect cell potenc compar nirmatrelvir x ray structur analysi show yh form coval bond cys catalyt center cl pro strong antivir activ favor pharmacokinet properti yh suggest potenti lead compound treatment covid
D000086402;D000086382
T067;T047;T005
36,229,358
parkinson diseas connect mitochondria inflammasom activ microglia foster neurotox inflammatori environ mammalian central nervous system cns drive patholog neurodegen diseas includ parkinson diseas pd moreov mitochondri fission promot microgli inflammatori respons vitro given nlrp inflammasom mitochondria central regul inflamm pd explor potenti function nlrp inflammasom mitochondri dynam pd specif propos induc microgli mitochondri fission promot nlrp depend neuroinflamm hereditari idiopath pd depth explor topic prompt valuabl discoveri under molecular mechan pd neuroinflamm identifi novel candid anti inflammatori therapeut pd ideal provid better outcom pd patient
D058847;D010300
T047;T123;T116
36,229,346
promis practic toward realis ai inform mental health care seri paper explor promis challeng artifici intellig ai base precis medicin tool mental health care clinic ethic regulatori perspect real world implement tool increas consid prime solut key issu mental health delay inaccur ineffici care deliveri similar machin learn base empir strategi becom commonplac psychiatr research potenti adequ deconstruct biopsychosoci complex mental health disord henc improv nosolog prognost prevent paradigm howev implement step need translat promis practic current hamper multipl interact challeng obstruct rang current technolog distant state clinic practic lack valid real world databas requir feed data intens ai algorithm model develop valid consider disconnect core principl clinic util ethic accept seri paper provid recommend challeng could address interdisciplinari perspect pave way toward framework mental health care leverag combin strength human intellig ai
D001185;D001523
T090;T066;T073;T048
36,229,345
promis model base psychiatri build comput model mental ill health comput model great potenti revolutionis psychiatri research clinic practic model use across multipl subfield includ comput psychiatri precis psychiatri goal vari understand mechan under disord deriv reliabl classif personalis predict rapid growth new tool data sourc eg digit data gamif social media requir understand constraint advantag differ model approach psychiatri seri paper take critic look rang comput model use psychiatri evalu advantag disadvantag differ purpos data sourc describ mechan driven mechan agnost comput model discuss interpret model crucial clinic translat base evalu provid recommend build comput model clinic use
D001523;D011570
T091;T097;T048
36,229,333
multipli twist chiral macrocycl clamp tether binaphthyl exhibit high circular polar luminesc bright invit cover issu masashi hasegawa co worker kitasto univers kyoto prefectur univers imag depict report multipli twist chiral macrocycl object kaleidoscop read full text articl chem
D049449
T070
36,229,315
ethmoid bone ideal graft strengthen nasal septum l strut among differ graft evalu base finit element analysi rhinoplasti asian short nose deform surgeon cut portion septal cartilag retain nasal septum l strut deviat nasal septum form surgeri forc soft tissu contractur although various autolog graft use reinforc l strut lack object mechan theori support clinic find studi present time
D012225;D009668
T061;T047
36,229,314
enhanc surviv acceler perfus skin flap recipi site follow administr human amniot membran rat model human amniot membran contain cellular part obligatori cell integr tissu remodel high tensil strength persist theoriz materi could function scaffold improv surviv ischem tissu random skin flap male albino wistar rat n random assign three group receiv differ model dorsal paravertebr area salin amniot membran sheet micron amniot membran digit photograph taken surviv area examin one week histolog analysi skin flap tissu perform express rate vascular endotheli growth factor apoptot protein examin surviv percentag increas time group howev one week implant increas surviv experiment group signific greater group control experiment group regular arrang collagen improv epitheli flap tissu also increas number inflammatori cell observ control group addit vegf apoptot protein express respect signific lower greater control group experiment group result show micron membran excel scaffold promot flap surviv
D000650;D058752
T018;T024
36,229,283
factor associ pneumococc vaccin uptak among vulner older adult unit state primari care set pneumococc vaccin uptak target set healthi peopl met among vulner unit state popul yet research suggest progress made primari care set studi assess factor associ gotten pneumococc vaccin among vulner adult age older studi use medic expenditur panel survey nation repres dataset elig individu age risk health condit year primari care provid usual sourc care n binari logist regress use test factor identifi literatur signific associ get pneumococc vaccin factor signific associ enter adjust multivari logist regress model generat odd endors factor given respond got vaccin collinear among variabl examin unaccept threshold correl signific threshold use got pneumococc vaccin p p time p higher odd also gotten influenza vaccin herp zoster vaccin colonoscopi respect time p higher odd diabet mellitus time p higher odd visit doctor three time time p higher odd seen doctor within last year concord statist model fit negat associ pneumococc vaccin go three doctor offic visit vs strongest posit associ found pneumococc vaccin get herp zoster vaccin influenza vaccin get colonoscopi result suggest choos get pneumococc vaccin may higher odd also get vaccin specif prevent screen
D007252;D053061
T121;T109;T129
36,229,223
research progress workplac health promot workplac ideal environ health promot activ mani countri region carri mani workplac health promot project achiev good result improv physic mental health employe improv econom benefit enterpris although research evid long term effect econom benefit need strengthen workplac health promot develop countri form complet theoret practic system worthi refer contrast theoret practic research workplac health promot china need strengthen paper summar theori project implement experi foreign workplac health promot analyz current situat influenc factor intervent research order promot format theoret system suitabl workplac health promot china better protect physic mental health occup group ensur econom benefit enterpris
D016272;D017132
T078;T091;T082
36,229,222
effect individu factor labor organ neck pain auto assembl object investig influenc individu factor labor organ preval neck pain hereinaft refer neck pain automot assembl provid basi enterpris optim neck pain intervent method cluster random sampl method taken januari automobil manufactur plant shiyan assembl year servic select musculoskelet disord questionnair use investig incid influenc factor neck pain pearson test trend test use compar data rate influenc factor neck pain analyz multivari logist regress result preval rate neck pain hereinaft refer preval rate neck pain automobil assembl within one year preval neck pain women higher men vs p preval neck pain relat length servic self assess fatigu work hour per week work workshop rest day per shift accumul rest time per shift p multivari logist regress analysi show risk neck pain women time higher men risk neck pain increas hour work per week rest work protect factor neck pain number rest per shift increas risk neck pain decreas r ci p conclus annual preval neck pain higher automobil assembl enterpris fulli consid influenc factor gender work hour per week number break arrang product
D009140;D009784
T047
36,229,221
case bromadiolon poison lead digest tract abdomin hemorrhag secondari paralyt ileus bromadiolon common known super warfarin long act coumarin dicoumarin rodenticid mechan bromadiolon main inhibit vitamin k epoxid reductas affect synthesi coagul factor caus blood coagul dysfunct system multipl organ hemorrhag report case bromadiolon poison patient digest tract abdomin hemorrhag well secondari paralyt ileus blood product transfus vitamin k supplement patient discharg physic condit improv suggesti clinician pay attent rare complic prevent miss diagnosi treat bromadiolon poison
D015110;D007418;D012378
T121;T047;T109;T131
36,229,220
determin chlorobenzen metabolit p chlorophenol urin solid phase extract gas chromatographi object method determin chlorobenzen metabolit p chlorophenol urin solid phase extract gas chromatographi establish method may urin sampl hydrolyz h ml concentr hydrochlor acid cool filter sampl enrich purifi oasi max cc spe column drip wash moll hydrochlor acid solut elut acetonitril eluent volum ml acetonitril determin gas chromatographi quantifi standard curv method result calibr curv method linear within rang gml show good linear r regress equat x determin limit gml limit quantit gml recoveri rate relat standard deviat rsd intra day measur rang rsd inter day measur rang conclus method could optim sampl pretreat elimin interfer impur sensit effici accur determin chlorobenzen metabolit p chlorophenol urin
D002733;D006851
T109;T130;T197
36,229,219
case acut fish gallbladd poison multipl organ dysfunct fish bile poison may damag human liver kidney caus degener necrosi also damag brain cell heart muscl result nervous system cardiovascular system lesion paper report case patient develop multipl organ dysfunct syndrom mod oral administr fish bile xiexin folk prescript eye diseas januari went poison occup diseas depart emerg depart qilu hospit receiv hemoperfus continu renal replac therapi crrt symptomat support treatment patient improv discharg crrt combin hp one rapid effect method treatment acut fish bile poison
D006464;D011041
T061;T037
36,229,218
one case extens high pressur inject injuri hand caus polyurethan materi articl report patient extens high pressur inject injuri hand caus mistaken inject polyurethan materi index finger diagnos treat depart orthoped huzhou central hospit digit arteri digit nerv involv polyurethan involv right palm along flexor tendon sheath index finger wrist due lack x ray develop scope first debrid small blood suppli fingertip poor final patient right index finger amput due infect necrosi mr b ultrasound perfect oper clarifi extent polyurethan involv initi thorough debrid multipl debrid necessari improv prognosi blood suppli finger poor blood suppli reconstruct skin flap transplant
D005383;D019651
T061;T037
36,229,217
analysi case toxic encephalopathi caus acut benzen poison paper mri manifest patient benzen toxic encephalopathi analyz lesion locat shape scope signal observ clinic manifest patient main central nervous system damag mri manifest characterist wide rang lesion shape sunflow like flame like bracket like butterfli like mri signal sheet like long long fluid attenu invers recoveri flair sequenc diffus weight imag dwi high signal appar diffus coeffeci adc map low equal high signal patient diagnosi unclear mri examin may provid clinic basi diagnosi
D001554;D020258
T109;T131;T037
36,229,216
analysi stressor mental status civil aviat pilot background major infecti diseas object studi stressor mental status civil aviat pilot background major infecti diseas method januari march cluster sampl method use select airlin pilot servic research object self made emot stress sourc questionnair chines version stress percept scale cpss self rate anxieti scale sas self rate depress scale sds use investig airlin pilot popul valid questionnair collect effect recoveri rate measur data conform normal distribut express x test analysi varianc use comparison group pearson correl use correl analysi data conform normal distribut express median quartil q q non parametr test use comparison group multipl linear stepwis regress use analyz influenc factor pressur percept addit amo softwar use construct structur equat model stress percept negat emot result background epidem main sourc stress civil aviat pilot risk possibl reduct incom risk contract covid pressur work risk possibl slow progress upgrad among first co pilot worri possibl reduct incom instructor p first co pilot captain airlin worri possibl slowdown upgrad progress instructor p p mean pressur percept pilot higher chines norm p standard score anxieti depress slight higher standard score chines norm non epidem situat p result multipl linear stepwis regress analysi show stress percept negat correl good famili relat p posit correl worri slow progress upgrad covid infect lack interperson communic incom reduct p pressur percept posit correl negat emot p result structur equat model show stress percept affect pilot negat emot direct indirect standard total effect anxieti depress hypochondriac fear compuls irrit respect conclus public health emerg impact mental status pilot pay attent stressor psycholog condit pilot time consid formul measur reliev stress pilot
D001359;D000086382;D003141;D000070356
T047;T090;T056;T097;T089;T067
36,229,215
analysi individu dosag monitor intervent radiolog staff tianjin citi object investig individu extern dose level intervent radiolog staff tianjin citi method intervent radiolog staff includ work radiat monitor project select studi subject march individu dose monitor result intervent radiolog staff differ age work year time medic institut analyz result among intervent radiolog worker male femal age year work year year annual effect dose per capita age group age group higher age group p annual effect dose per capita work year higher work year annual effect dose per capita work year higher work year p median per capita annual effect dose intervent radiolog staff msv intervent radiolog staff annual effect dose msva collect dose distribut ration sr differ effect dose per capita year statist signific h p per capita annual effect dose intervent radiolog staff tertiari medic institut higher secondari medic institut differ statist signific p conclus person dose intervent radiolog staff tianjin citi low level necessari emphas radiat hazard protect intervent radiolog staff tertiari medic institut year old year old age group work year group
D016273;D011834;D011835
T059;T061;T037
36,229,214
investig newli diagnos pneumoconiosi artifici quartz stone manufactur artifici quartz dust exposur may caus associ pneumoconiosi novemb juli total case silicosi associ artifici quartz stone manufactur diagnos treat occup diseas depart suzhou fifth peopl hospit averag age onset year averag work age dust exposur yearsth main featur high kv chest radiographi ps shadow strip shadow ct imag find show diffus small nodul ground glass shadow band shadow lesion main distribut upper lung accompani pleural thicken lymphadenopathi calcif pulmonari function impair main mild restrict ventil disord bronchial mucosa longitudin plica main manifest tracheoscopi age silicosi worker artifici quartz stone product enterpris younger work age dust exposur short lung function bronchial mucosa certain degre damag effect prevent measur taken time
D016273;D011009;D012829
T047;T037
36,229,213
effect exercis intervent musculoskelet disord nurs staff object evalu effect exercis intervent musculoskelet disord msd nurs staff method septemb search articl exercis intervent nurs musculoskelet diseas embas pubm clinicaltrail wanfang cnki databas septemb search period databas creation august qualiti articl evalu cochran bias risk assess tool minor systemat review method narrat synthesi use analyz research result result total studi includ includ random control trial quasi experi sampl size experiment group control group depend type exercis intervent muscl strength train muscl strength trainingstretchflex train back school program reduc local pain nurs staff among muscl strength train improv nurs staff muscl function qualiti life muscl strength trainingstretchingflex train increas muscl strength rang physic activ self efficaci back school program effect improv poor postur conclus exercis intervent effect control musculoskelet disord symptom nurs staff manag develop exercis strategi differ msd symptom
D009140;D009740
T047;T097
36,229,212
survey cervic lumbar spine diseas express deliveri employe object understand current situat influenc factor cervic lumbar spine diseas express deliveri employe provid scientif basi carri occup health protect target manner method februari januari current situat research method use obtain express deliveri employe cluster sampl onlin questionnair use investig sociodemograph characterist emot characterist clinic data obtain digit x ray dr examin neck waist pearson test multivari logist regress use analyz influenc factor cervic lumbar spine diseas express deliveri employe result preval rate cervic spine lumbar spine diseas among express deliveri employe respect univari analysi show statist signific differ distribut cervic lumbar spine diseas among express deliveri employe differ age length servic work hour per week differ degre distress due emot factor p multivari analysi show express deliveri employe age year old higher risk cervic spine diseas p express deliveri employe work hour per week lower risk cervic spine diseas p express deliveri employe age year old lower risk lumbar spine diseas p risk lumbar spine diseas higher among express deliveri worker suffer moder distress due emot factor anxieti depress irrit past week p conclus preval cervic lumbar spine diseas relat high among express deliveri employe recommend adjust week work hour express deliveri employe organ psycholog counsel train effect protect occup health right express deliveri employe
D006297;D016272
T078;T091;T080;T033
36,229,211
occup stress air traffic control influenc factor object investig occup stress status air traffic control atc analyz influenc factor method use cluster sampl method atc air traffic manag bureau select investig object job content questionnair jcq effort reward imbal questionnair eri use measur work requir independ imbal type eri type occup stress separ analyz influenc factor result atc atg work requir independ imbal type occup stress atg eri type occup stress univari analysi show factor marit status degre educ age length servic titl job post famili month incom view regular train occurr emerg unsaf event last month month night shift frequenc various degre influenc differ factor score jcq eri p logist regress analysi show level jcq type occup stress atc junior titl probation higher intermediatesenior titl p eri type occup stress probation junior titl atc lower intermediatesenior titl p eri jcq type occup stress level tower post atc higher two job post atc p atc consid regular train disadvantag advantag show lower eri type occup stress level consid advantag disadvantag p eri type occup stress level atc experienc emerg unsaf event last month higher nt p conclus larg proport atc occup stress manag adjust polici pay attent occup stress atl
D000073397
T054;T048;T033
36,229,210
effect arsenic main metabolit cell apoptosi express pro apoptot gene bad bik object investig effect arsenic main metabolit apoptosi human lung adenocarcinoma cell line express pro apoptot gene bad bik method octob cell recov cultur cell viabil detect cell count reagent cck determin concentr time sodium arsenit exposur studi divid naaso exposur group metobol le expour group metabolit comparison group subdivid control group monomethylarsin acid exposur group moll dimethylarsin acid exposur group moll sodium arsenit dose group subdivid group control group moll sodium arsenit naaso hoechst propidium iodid doubl stain hopi use observ cell apoptosi real time quantit polymeras chain reaction qrt pcr use detect express level bad bik mrna cell exposur western blot use detect protein express bad p bad bik cleav bik downstream protein poli adp ribos polymeras parp cytochrom c cyt c use spectrophotometri detect activ chang caspas result compar control group proport apoptot cell moll naaso dose group increas signific p express level bad bik mrna protein express level bad p bad bik cleav bik parp cyt c increas p activ caspas signific increas signific differ p compar control group express level bad mrna dma exposur group increas signific differ p signific differ express level bik mrna p signific differ express level bad bik mrna poison group p compar control group gray valu protein bad bik parp cyt c expos mma signific differ two group p gray valu protein bad bik parp cyt c expos dma differ two group p conclus sodium arsenit induc overexpress bad bik protein initi negat feedback regul phosphoryl bad degrad bik activ downstream protein parp cyt c caspas pathway mediat apoptosi cell
D001151;D011042
T121;T131;T196
36,229,209
effect pregnant rat expos radio frequenc electromagnet field hippocamp morpholog nerv growth factor offspr rat object explor effect exposur pregnant rat radio frequenc electromagnet field ultrastructur hippocampus level obes relat protein fto nerv growth factor ngf offspr rat method septemb healthi week old wistar rat select includ femal rat g male rat g male femal mice mate cage ratio everi night smear result show sperm posit mate success day regard day pregnanc pregnant rat random divid experiment group control group rat group experiment group expos mhz wi fi mhzwi fi respect three control group expos virtual exposur hour day day three batch end exposur offspr group rais week ultrastructur chang hippocampus observ transmiss electron microscopi fto level hippocampus determin western blot ngf level brain tissu determin elisa result transmiss electron microscopi show nuclei hippocamp tissu femal male rat mhz group slight contract cytoplasm slight edema nuclei male rat obvious irregular offspr male femal rat wi fi group nucleus hippocamp tissu contract serious cell membran irregular cytoplasm appear obvious edema mhzwi fi group nuclei hippocamp tissu male femal offspr rat sever contract nuclear membran irregular cytoplasm sever edema signific differ fto level among group p compar group ngf content hippocampus offspr rat mhzwi fi group signific higher p conclus exposur radio frequenc electromagnet field damag morpholog structur hippocamp tissu offspr stimul increas ngf express hippocampus
D004574;D020932
T123;T116;T070
36,229,208
improv effect lycium barbarum polysaccharid intestin flora pregnant rat offspr chronic stress object understand improv effect lycium barbarum polysaccharid lbp intestin flora mother mice pregnanc offspr experienc chronic stress provid new idea improv effect stress intestin tract method juli octob spf grade femal sd rat select divid control group stress group stresslbp group rat group chronic unpredict mild stimul model pregnanc establish day mgkg lbp solut administ gavag th day stress venous blood medial canthus femal mice collect st day stress st th th st day respect cortisol measur corticosteron concentr calcul fresh fece famal mice stress day postnat offspr mice collect illumina miseq sequenc technolog alpha divers communiti composit use analyz divers structur intestin flora result th th day stress plasma corticosteron concentr femal mice stress group stresslbp group higher control group p alpha divers femal mice ace index stress group lower control group p analysi intestin flora structur show speci level proport lachnospiracea lactobacillus stresslbp group higher stress group control group order level proport clostridial stresslbp group higher stress group lower control group proport lactobacillal higher stress group control group alpha divers offspr group shannon index ace index chao index stresslbp offspr group higher stress offspr group p proport lactobacillus stresslbp offspr group higher control offspr group stress offspr group proport lachnospiracea ruminococcacea stresslbp offspr group higher stress offspr group proport bacteroidal stresslbp offspr group lower stress offspr group proport clostridial stresslbp offspr group higher stress control offspr group conclus intervent lbp may improv chang intestin flora divers abund flora structur mother mice offspr caus pregnanc stress therebi maintain balanc intestin flora
D004365;D000069196
T121;T001;T123;T007
36,229,207
toxic effect long term pesticid exposur key gene discoveri object bioinformat method use mine differenti express gene deg enrich signal pathway induc chronic pesticid exposur explor potenti pathogen mechan key gene method juli high throughput gene express profil data relat pesticid toxic download gene express omnibus geo databas obtain deg sampl american male farm worker expos pesticid long time industri worker function enrich analysi go kegg geme set enrich analysi gsea perform r packag clusterprofil string cytoscap tool appli construct visual protein interact network help mcode cytohubba plugin gene function modul obtain hub gene screen result deg screen gse dataset includ regul gene regul gene result go kegg gsea main enrich biolog function regul neuron project develop regul locomot ribosom protein synthesi pathway relat complex nervous system diseas parkinson diseas comprehens screen show klf hub gene pesticid exposur fold chang p conclus long term exposur pesticid result differenti express multipl gene expos popul may involv patholog chang nervous system regul klf relat biolog pathway
D020869;D010575
T059;T131;T063
36,229,206
relationship valv ablat bladder function children posterior urethr valv disord studi investig effect valv ablat bladder function patient posterior urethr valv clinic data patient posterior urethr valv receiv urodynam examin valv ablat retrospect analyzedth bladder complianc improv urin storag oper maximum detrusor pressur decreas micturit postop urinari system ultrasound show residu urin volum group signific improv upper urinari tract hydrocephalus signific less group improv bladder complianc signific higher group improv maximum urin flow rate signific higher group improv p valv ablat limit effect improv bladder function patient puv valv incis help improv maximum bladder volum residu urin volum maximum urinari flow rate certain effect bladder complianc maximum detrusor pressur
D014524;D001743
T047;T023
36,229,205
risk factor postop void dysfunct children congenit anorect malform studi analyz clinic data children anorect malform arm underw surgeri explor relat factor postop void dysfunct vd total children includ male femal age year enrol follow normal void function found case vd case found middl high clinic classif ci multipl surgeri ci associ spinal deform ci abnorm postop defec ci risk factor vd arm p urodynam studi earli intervent carri children vd arm surgeri
D000071056
T190;T019
36,229,204
associ studi kcne famili gene polymorph potassium channel gene suscept atrial fibril object investig relationship kcne famili gene polymorph potassium channel gene suscept atrial fibril af method case control studi total subject studi patient atrial fibril select depart cardiovascular medicin putuo hospit affili shanghai univers tradit chines medicin januari decemb healthi peopl select physic examin popul period dna sequenc technolog polymeras chain reaction pcr use detect genotyp allel frequenc rs kcne rs kcne rs rs kcne rs kcne result age subject atrial fibril group control group year respect p men subject account men men two group respect p distribut frequenc allel c rs gene kcne allel rs gene kcne allel g rs gene kcne signific differ group p adjust sex smoke hypertens cardiac insuffici factor found increas frequenc three loci would increas risk atrial fibril rs ci rs ci rs ci conclus rs kcne rs kcne rs kcne signific associ suscept atrial fibril
D001281;D024642
T047;T046;T123;T116
36,229,203
establish effect evalu nomogram model diagnosi predict pulmonari hypertens patient chronic obstruct pulmonari diseas object construct diagnost predict model chronic obstruct pulmonari diseas complic pulmonari hypertens copd ph evalu effect method total copd patient treat hospit januari decemb retrospect collect divid train cohort case valid cohort case accord ratio accord inclus time data includ demograph data smoke status histori diseas clinic examin collect patient medic record electron medic record system multivari logist regress model use explor relat factor copd ph nomogram model construct use rms program packag calibr curv use evalu consist predict probabl model actual result c index area receiv oper characterist curv roc use evalu discrimin model decis curv analysi dca use evalu clinic practic model result train cohort age year respect signific differ age composit valid cohort respect p signific differ train cohort valid cohort p multivari logist regress analysi train cohort show age year ci smoke status former current smoke ci respect nt probnp ngl ci right atrial diamet ci copd relat factor ph base factor ph nomogram copd model set develop onlin tool https ph shinyappsiozhonghua ph calibr c index ci train cohort valid cohort respect calibr curv close diagon train cohort valid cohort auc ci nomogram model train cohort valid cohort roc curv show optim threshold train cohort sensit specif valu respect optim threshold valid cohort sensit specif valu respect dca analysi show nomogram model provid better net benefit variabl select variabl select strategi threshold probabl greater train valid cohort respect conclus nomogram model diagnosi predict copd ph simpl accur good clinic applic prospect
D006976;D029424
T047;T046
36,229,202
prognost valu pulmonari hemodynam paramet predict surviv acut coronari syndrom object explor characterist prognost valu pulmonari hemodynam patient acut coronari syndrom ac method prospect multicent registri studi pulmonari hypertens due left heart diseas consecut ac patient underw coronari angiographi combin left right heart catheter hospit januari novemb involv primari endpoint caus mortal prognost variabl identifi lasso analysi includ global registri acut coronari event grace score model perform evalu addit hemodynam paramet result total patient enrol age year total male femal recruit median follow time month right heart catheter assess mean pulmonari arteri pressur mpap systol pulmonari arteri pressur spap diastol pressur gradient dpg found signific predictor surviv ac adjust age sex adjust hr ci mpap spap dpg respect p appli present cohort patient median grace score point c index ci predict mortal addit mpap dpg grace score c index increas ci ci respect compar two model addit mpap dpg integr discriminatori index idi ci p ci p respect conclus pulmonari hemodynam predict surviv ac patient provid increment prognost valu risk assess ac
D054058
T047
36,229,201
effect topic glucocorticoid treat phimosi urinari tract infect vesicoureter reflux infant object evalu effect topic glucocorticoid treat phimosi urinarytract infect uti vesicoureter reflux vur infant method clinic data infant uti diagnos primari vur admit hospit januari januari retrospect analyz children divid three group effect group topic glucocorticoid effect treatment phimosi ineffect group topic glucocorticoid ineffect treatment phimosi untreat group phimosi treat age onset degre reflux side indic compar understand effect topic glucocorticoid treat phimosi clinic characterist repeat uti vur treat phimosi untreat phimosi result total children includ among case treat topic glucocorticoid phimosi case effect group age month case ineffect group age month case untreat group age monthsth effect rate topic glucocorticoid treatment phimosi case recurr uti effect group case recurr uti untreat group differ two group statist signific p conclus treatment phimosi topic glucocorticoid effect easi perform cost effect method effect reduc risk recurr uti infant primari vur
D010688;D014552;D014718
T047;T033
36,229,200
analysi video urodynam clinic featur non neuropath lower urinari tract dysfunct children object analyz video urodynam vud clinic featur non neuropath lower urinari tract dysfunct nnlutd children method children diagnos nnlutd first affili hospit zhengzhou univers januari decemb includ children neurolog rectal dysfunct anatom abnorm exclud vud urinalysi perform children divid group accord normal group normal group detrusor overact group group detrusor sphincter dyssynergia group dsd group detrusor underact group du group vud clinic featur vesicoureter reflux vur urinari tract infect uti analyz result total children includ studi includ male femal age year vud show case normal group case group case dsd group case du group compar normal group group proport vur dsd group du group signific higher vs p proport male children signific higher femal children vur group vs p compar group proport uti dsd group du group signific higher vs p proport femal children signific higher male children uti normal group group du group vs vs vs p maximum detrusor pressur dsd group signific higher normal group group du group vs cmh p cmh kpa compar normal group group post void residu dsd group du group signific increas vs ml p proport lower bladder complianc signific increas vs p compar normal group maximum bladder capac dsd du group signific decreas vs ml p proport urgenc signific differ four group normal group group dsd group du group p proport dysuria signific differ normal group group dsd group du group p conclus children differ condit nnlutd distinct video urodynam featur higher ratio vur uti dsd du children may associ reduc bladder complianc increas post void residu vud use diagnosi treatment refractori children nnlutd
D001748;D014552;D014718
T047
36,229,199
evalu bladder function sleep pattern children primari mono symptomat nocturn enuresi polysomnographi combin ambulatori urodynam monitor object evalu bladder function sleep pattern children primari mono symptomat nocturn enuresi pmne polysomnographi psg ambulatori urodynam monitor aum method octob octob forti three patient pmne select pmne group first affili hospit zhengzhou univers subdivid sever pmne group enuresi timesweek non sever pmne group enuresi time timesweek accord sever convent urodynam cud aum psg examin bladder diari complet pmne group control group consist children normal psg find without lower urinari tract symptom result sever pmne group includ male femal age year nocturn enuresi number per week non sever pmne group includ male femal age year nocturn enuresi number per week incid nocturn polyuria reduct maximum bladder capac pmne group respect incid frequenc detrusor overact sever pmne group signific higher non sever pmne group vs timesh vs timesh respect p found psg sever pmne group signific higher cortic arous index apnea hypopnea index ahi percentag nn phase total sleep time compar control group vs timesh vs timesh timesh vs timesh p sleep effici sever pmne group substanti lower non sever pmne group vs cortic arous index ahi signific greater non sever pmne group timesh vs timesh timesh vs timesh p pmne group posit correl cortic arous index nocturn frequenc ahi r p conclus children pmne nocturn bladder dysfunct abnorm sleep pattern certain correl psg aum necessari evalu treatment children pmne
D053206;D014563
T042;T048
36,229,198
establish valid predict model neurogen urinari tract injuri children object establish predict model upper urinari tract damag children neurogen bladder verifi efficaci method januari decemb children nb children hospit chongq medic univers children nb first affili hospit zhengzhou univers select research object former set train set latter set valid set general paramet two compar independ risk factor upper urinari tract damag children nb screen lasso regress multivari logist regress analysi nomogram predict model establish model valid intern extern train set valid set respect area receiv oper curv roc use verifi accuraci model result total children nb includ studi includ male femal age year signific differ paramet except age train set valid set p lasso regress multivari logist regress analysi show detrusor leakag point pressur dlpp cmh ci cmh kpa overact bladder oab ci bladder complianc bc mlcm h ci histori previous urinari tract infect ci abdomin pressureoth void pattern ci risk factor upper urinari tract damag children nb p paramet use establish nomogram model upper urinari tract damag children nb intern extern valid result show auc valu train valid set ci ci respect conclus predict model upper urinari tract damag children nb construct studi high discrimin accuraci clinic applic help clinician identifi high risk patient make individu treatment design patient
D001750;D014551
T047;T023;T048
36,229,197
improv understand hepat diseas relat pulmonari vascular diseas hepat diseas relat pulmonari vascular diseas refer chang structur function pulmonari circul caus liver parenchym hepat vascular diseas main includ hepatopulmonari syndrom character hypoxemia portopulmonari hypertens character pulmonari hypertens hepat vascular shunt character increas cardiac output pulmonari hypertens earli diagnosi treatment liver diseas earli evalu liver transplant may signific improv prognosi patient hepat diseas relat pulmonari vascular diseas moreov necessari improv clinician understand diseas strengthen multidisciplinari cooper improv level diagnosi treatment
D020065;D006975;D006976;D008171;D014652
T047;T046
36,229,196
pay attent lower urinari tract dysfunct clinic applic urodynam studi children lower urinari tract dysfunct lutd dysfunct bladder urethra bladder fill void phase two general categori neurogen non neurogen caus upper urinari tract damag left untreat urodynam studi ud object detect function detrusor sphincter urethra well predict damag lutd upper urinari tract howev develop ud children china popular affect accur diagnosi treatment lutd articl review import pay attent lutd promot clinic applic ud children improv diagnosi treatment lutd children
D001743;D014563
T023;T042
36,229,191
tempor dynam mog antibodi children acquir demyelin syndrom spectrum myelin oligodendrocyt glycoprotein mog antibodi associ disord mogad compris monophas diseas acut dissemin encephalomyel adem optic neuriti transvers myeliti relaps cours present persist high mog antibodi mog immunoglobulin g igg found patient relaps diseas cours prognost factor determin clinic cours children first mogad still lack object studi assess clinic laboratori prognost paramet risk relaps tempor dynam mog igg titer children mogad correl clinic present diseas cours
D004673;D009471;D009902
T047
36,229,190
rate retin layer thin biomark convers progress diseas multipl sclerosi diagnosi secondari progress multipl sclerosi spms often delay lack object clinic tool increas diagnost uncertainti hamper therapeut develop progress multipl sclerosi ms optic coher tomographi oct propos promis biomark progress neurodegener explor longitudin chang thick retin layer oct individu relaps remit ms rrms convert spms vs match patient rrms convert spms hypothesi cohort exhibit differ rate retin thin
D009103;D020528
T047
36,229,189
b cell reconstitut autolog hematopoiet stem cell transplant multipl sclerosi autolog hematopoiet stem cell transplant ahsct increas use treat aggress form multipl sclerosi ms procedur believ result immun reset restor self toler immun system immun reconstitut extens studi cell limit extent b cell increas evid suggest import role b cell ms pathogenesi sought better understand reconstitut extent renew b cell system ahsct ms
D018380;D009103
T061;T047
36,229,188
imag characterist choroid plexus presymptomat multipl sclerosi retrospect studi recent imag studi suggest possibl involv choroid plexus cp multipl sclerosi ms investig whether cp chang alreadi detect earliest stage ms preced symptom onset
D009103
T047
36,229,169
effect transderm fentanyl treatment acut pain inflamm rat adjuv induc monoarthr elimin unnecessari pain import requir perform anim experiment includ reduc control pain anim use pain research goal studi refin adjuv induc monoarthr model rat provid analgesia transderm fentanyl solut tfs male femal spragu dawley rat singl pair hous inject l complet freund adjuv cfa left ankl joint cfa inject rat treat singl dose transderm fentanyl solut mgkg compar untreat cfa inject group sham group receiv either treatment tfs treatment mgkg h test dose tfs reduc mechan hyperalgesia improv mobil stanc rear lame score h cfa inject joint circumfer reduc tfs treatment signific differ detect dose tfs singl pair hous rat treatment tfs appear interfer model develop characterist howev overal analges effect transient sever opioid relat side effect observ
D005283;D059787
T121;T109;T184
36,229,166
learn curv flow divers posterior circul aneurysm long term intern multicent cohort studi flow divers gradual becom standard treatment intracrani aneurysm anterior circul recent label use flow divert treat posterior circul aneurysm also increas despit initi concern ruptur suboptim result studi aim explor chang complic rate treatment outcom across time posterior circul aneurysm treat use flow divers evalu mechan variabl could potenti explain chang outcom
D057510;D002532;D004621
T061;T047;T046;T190
36,229,165
diagnost perform whole bodi ultra low dose ct detect mechan ventriculoperiton shunt complic retrospect analysi radiograph shunt seri still imag techniqu choic radiolog evalu vp shunt complic radiograph shunt seri associ high radiat exposur low diagnost perform aim investig diagnost perform whole bodi ultra low dose ct detect mechan ventriculoperiton shunt complic
D017287;D000069079
T061;T037
36,229,164
swi mr imag microscop imag diagnosi astrocyt oligodendrogli tumor despit advanc molecular imag preoper diagnosi astrocytoma oligodendroglioma challeng present studi assess whether swi use distinguish astrocytoma oligodendroglioma whether malign grade glioma possibl
D009837;D001932;D001254;D005910
T191
36,229,163
distinct brain malform zhu tokita takenouchi kim syndrom zhu tokita takenouchi kim syndrom sever multisystem malform disord character development delay divers array congenit abnorm howev current identifi phenotyp compon provid limit guidanc diagnost situat due nonspecif variabl featur report case seri individu molecular diagnosi zhu tokita takenouchi kim syndrom ascertain present neuron migrat disord periventricular nodular heterotopia
D054091;D001927;D008607
T047;T048
36,229,162
peer learn program metric pediatr neuroradiolog exampl american colleg radiolog offer accredit pathway program use peer learn share feasibl outcom data pilot peer learn program pediatr neuroradiolog section design follow american colleg radiolog peer learn accredit pathway criteria
D019985;D000072177
T097;T081
36,229,155
protocol cluster randomis control trial evalu effect onlin parent intervent promot oral health year old australian children dental decay major problem among australian children prevent good self care limit sugar intak mani parentscaregiv lack skill confid help children adopt practic trial evalu efficaci healthi habit tripl p oral health web base onlin programm improv children oral health relat behaviour toothbrush snack practic dental visit relat parent practic therebi prevent dental cari
D003731;D000079382
T047;T058;T033
36,229,154
factor influenc death anxieti among chines patient cancer cross section studi purpos studi investig death anxieti status among chines patient cancer identifi factor affect death anxieti
D009369;D011788
T191;T078
36,229,153
real time automat quantif left ventricular function hand held ultrasound devic patient suspect heart failur feasibl studi diagnost test data general practition nurs cardiologist evalu feasibl reliabl hand held ultrasound hud examin real time automat decis make softwar eject fraction autoef mitral annular plane systol excurs automaps novic general practition intermedi user regist cardiac nurs expert user cardiologist respect compar refer echocardiographi cardiologist outpati cohort suspect heart failur hf
D000072096;D058005;D006333
T046;T047;T097
36,229,152
influenc outcom less full time work medic profess systemat review protocol impoverish medic workforc global phenomenon impact patient care signific greater flexibl work pattern one approach polici maker adopt address issu expans less full time ltft work form part studi suggest ltft work potenti improv recruit retent align doctor increas want balanc career commit interest less well understood influenc factor outcom relat ltft work among doctor protocol outlin methodolog systemat review evalu exist knowledg ltft work medic profess
D006282;D012107
T081;T170;T169;T097;T096;T062
36,229,151
inequ healthcar disrupt covid pandem evid uk popul base longitudin studi investig associ multipl sociodemograph characterist sex age occup social class educ ethnic self report healthcar disrupt earli stage covid pandem
D000086382
T047;T067
36,229,150
hiv test uptak determin among adolesc young peopl burundi cross section analysi demograph health survey assess hiv test uptak determin among adolesc young adult
D015658
T047
36,229,149
analysi nicotin depend among daili smoker china evid cross section studi zhejiang provinc current studi aim assess level nicotin depend influenc factor among daili smoker zhejiang china
D014029
T048
36,229,148
commerci actor use differ type power influenc polici restrict food market qualit studi polici actor thailand limit research focus explicit understand commerci actor use differ form power influenc polici decis make thailand studi aim identifi food industri use structur instrument discurs power influenc polici restrict food market thailand
D040541;D011050
T057;T064
36,229,147
live mind improv health develop play randomis control trial evalu comprehens ecc programm scale ghana mani children develop countri grow environ lack stimul lead defici earli year develop sever efficaci trial earli childhood care educ ecc programm demonstr potenti improv child develop evid whether effect sustain programm scale much mix studi evalu whether ecc programm shown effect efficaci trial maintain effect taken scale govern ghana gog find provid critic evid gog effect programm invest well blueprint design scale ecc programm develop countri expand invest ecc programm
D008603;D012574
T041;T092;T073
36,229,146
workplac factor associ employe alcohol use wirus cross section studi sociodemograph predictor employe alcohol use well establish literatur knowledg associ workplac factor alcohol use less explor aim studi explor whether workplac factor associ employe alcohol use consumpt alcohol relat problem
D000437;D017132
T048;T082
36,229,145
scope target review support develop spirit consort extens randomis control trial surrog primari endpoint protocol use surrog endpoint substitut primari patient relev outcom enabl randomis control trial rcts conduct effici shorter time smaller sampl size lower cost howev current consensus driven guidelin report rcts use surrog endpoint primari outcom therefor seek develop spirit standard protocol item recommend intervent trial consort consolid standard report trial extens improv design report trial initi step scope target review identifi potenti item inclus extens particip contribut delphi consensus process
D011642;D012107
T073;T081;T170;T169;T062;T096
36,229,144
protocol scope review misus psychoact medicin consequ misus psychoact medicin especi prescript opioid also benzodiazepin hypnot sedat becom signific public health issu countri especi usa extens document well canada australia howev european union eu publish literatur topic scarc heterogen regard definit sourc data tool method analysisth aim scope review map key concept psychoact medicin misus examin exist bodi evid topic eu data possibl consequ medicin misus advers drug reaction poison hospitalis death also analys
D010380;D012107
T058;T081;T170;T169;T062;T096
36,229,143
preval polypharmaci associ advers outcom risk factor among children asthma usa cross section studi estim preval polypharmaci identifi risk factor examin relat advers outcom us children asthma
D001249;D019338
T061;T047
36,229,142
koori quit pack mailout smoke cessat support aborigin torr strait island peopl smoke feasibl studi protocol smoke remain lead prevent caus death aborigin torr strait island peopl australia aborigin torr strait island peopl smoke like make quit attempt non aborigin counterpart less like sustain quit attempt littl avail evid specif indigen peopl inform best practic smoke cessat careth provis free koori quit pack option nicotin replac therapi sent mail may feasibl accept effect way access stop smoke support aborigin torr strait island peopl
D006303;D016540
T055;T058
36,229,141
food insecur among postsecondari intern student scope review protocol intern student make signific contribut host institut countri yet research show intern student financi mean fend meet financi oblig entir studi programm student signific risk food insecur object scope review synthesis avail inform factor relat food insecur among intern student studi postsecondari educ institut identifi type food insecur intervent implement address issu
D003695;D012107
T093;T058;T081;T170;T169;T062;T096
36,229,140
develop children born young mother first second generat hiv acquisit eastern cape provinc south africa cross section studi intergener effect hiv requir long term investig compar development outcom differ generat impact hiv children mother live hiv second generat ie recent infect mother third generat ie children perinat infect mother
D015658;D009035
T099;T047;T092
36,229,139
novel score system base clinic examin predict hospit mortal acut coronari syndrom patient retrospect cohort studi studi aim develop padjadjaran mortal acut coronari syndrom padma score predict hospit mortal acut coronari syndrom ac patient base clinic examin addit also compar predict valu padma score global registri acut coronari event grace canada acut coronari syndrom c ac portugues registri acut coronari syndrom proac risk score
D054058
T047
36,229,137
cerebrovascular anatomi laboratori research educ innov futur direct past centuri major advanc field cerebrovascular anatom research transform craft cerebrovascular surgeri modern art thorough anatom understand complex cerebrovascular anatomi crucial success surgic procedur despit clear descript anatom norm variat exist literatur research topic far diminish articl review root earli contemporari evolut status cerebrovascular skull base anatom research field various aspect limit also discuss differ area amen potenti improv futur direct
D012106;D019291
T062;T029
36,229,136
endoscop techniqu vascular neurosurgeri section review select criteria best practic endoscop cerebrovascular surgeri focus pure endoscop endonas approach although approach still play limit role open vascular neurosurgeri offer robust potenti safer techniqu establish visual vascular control particular well select patholog aneurysm proxim circul requir strong multidisciplinari experi endoscop anatomi surgic techniqu advanc reconstruct techniqu instrument design maneuv within relat novel corridor applic
D009493;D019651
T061;T091
36,229,135
exoscop cerebrovascular neurosurgeri exoscop technolog successor oper microscop cerebrovascular neurosurgeri offer advantag includ improv oper field magnif resolut light ergonom team cohes microsurg train howev advantag use exoscop must weigh learn curv adopt especi senior microneurosurgeon exoscop technolog refin seamless integr robot autom augment realiti hand free real time neuronavig anticip
D009493
T091
36,229,134
applic big data vascular neurosurgeri big data studi rise vascular neurosurgeri advanc comput process power combin vast amount digit data collect store electron medic record led studi use machin learn deep learn algorithm applic artifici intellig big data challeng gold standard model random control trial introduc pragmat research design includ registri registri base random trail matur cerebrovascular diseas studi studi larger patient sampl size allow compel conclus reach higher confid pertain diagnosi treatment outcom nuanc understand less common present ill follow review critic discuss big data applic vascular neurosurgeri well implic qualiti improv innov global neurosurgeri
D000077558;D009493
T091;T170
36,229,133
cavern malform artifici intellig machin learn applic signific progress made use artifici intellig ai clinic medicin past decad clinic develop ai face challeng although spectrum ai applic grow within clinic medicin includ subspecialti neurosurgeri applic focus cerebr cavern malform ccms relat scarc recent introduc brainstem cavern malform bscm grade scale approach triangl safe entri zone system provid discret framework explor futur machin learn ml applic ai system given immens scalabl model signific resourc like alloc pursu futur effort
D001185;D000069550
T090;T066;T073
36,229,132
cavern malform updat surgic manag biolog cavern malform cms low flow vascular lesion central nervous system prone symptomat hemorrhag cms estim present approxim popul usual character relat benign clinic cours stay asymptomat mani patient howev depend anatom locat cms caus signific morbid due symptom seizur focal neurolog deficit time caus symptomat hemorrhag nonsystemat review aim summar import recent clinic research focus biolog surgic manag cms publish sinc
D020786
T191;T019
36,229,131
brain arterioven malform status open surgeri random trial unruptur brain arterioven malform result random trial unruptur brain arterioven malform aruba suggest observ alon result less morbid mortal intervent lesion find generat signific controversi throughout cerebrovascular communiti result sever subsequ studi investig role microsurg resect aruba elig patient herein provid brief overview aruba trial subsequ critic result public challeng find aruba discuss avail data regard effect aruba arterioven malform avm treatment
D002538;D016634
T061;T019
36,229,130
biolog hemodynam aneurysm ruptur predict ruptur risk intracrani aneurysm among one critic question vascular surgeri process govern aneurysm growth multifacet complex may summar three compon hemodynam biolog mechan review connect literatur three disciplin identifi consider stride recent histori current gap research taken togeth find field elucid certain aneurysm ruptur wherea other remain stabl paramet could eventu inform translat predict model optim risk evalu physician decis make treatment option aneurysm
D017542;D002532
T047;T046;T190
36,229,129
dolichoectat vertebrobasilar arteri aneurysm intracrani dolichoectasia main affect posterior circul age popul may develop aneurysmat format without clear neck close circul vertebrobasilar dolichoectat arteri aneurysm may lead thromboembol complic mass effect brainstem surround cranial nerv treatment high riski especi older patient larg giant aneurysmat format vascular plastic collater format might stabil aneurysmat format etiolog natur histori behind anomali unknown best treatment option differ stage diseas
D002532;D014715
T047;T046;T190
36,229,128
rethink cerebr bypass surgeri despit evolut indic cerebr bypass remain import treatment select patient moyamoya diseas steno occlus cerebrovascular diseas complex aneurysm tumor ongo advanc patient select recent strateg technic technolog innov facilit tailor construct lower complic rate continu reshap field consolid cerebr bypass special center like continu complex patholog requir treatment revascular construct perform increas
D002548;D002561;D009072
T061;T047
36,229,127
evolut cerebrovascular bypass conceptu framework technic nuanc initi clinic experi fourth generat bypass cerebrovascular bypass undergon remark evolut sinc initi descript recent develop requir conceptu fourth generat bypass techniqu encompass unconvent sutur techniqu type eg intralumin sutur atyp vascular construct type b eg middl communic arteri bypass cohort studi report bypass oper perform singl cerebrovascular neurosurgeon among total cohort bypass bypass treatment complex aneurysm case although challeng oper empow novel approach varieti otherwis untreat lesion
D002548;D002532
T061;T047;T046;T190
36,229,126
minim invas outpati aneurysm surgeri new concept anterior circul aneurysm classic treat use pterion pt craniotomi minim invas altern pt craniotomi success use treat vascular patholog anterior circul approach offer smaller incis reduc tissu dissect result shorter hospit stay improv cosmet result compar outcom aneurysm treatment compar classic open approach supraorbit later supraorbit lso mini pt minim interhemispher endoscop transpterion port approach etpa best suit differ aneurysm target outpati aneurysm surgeri possibl use minim invas approach
D017542;D002532
T047;T046;T190
36,229,125
wide neck bifurc aneurysm balanc open endovascular therapi wide neck aneurysm wna often requir advanc open surgic endovascular techniqu achiev adequ aneurysm occlus microsurg treatment often requir advanc clip configur occasion complex open surgic techniqu requir advanc endovascular therapi evt devic expand endovascular treatment option wnas improv aneurysm occlus rate compar primari coil certain evt requir dual antiplatelet therapi limit use ruptur set evid suggest microsurg treatment remain consider treatment ruptur wnas perhap novel endovascular techniqu devic evt first line treatment unruptur set
D017542;D004621;D057510;D002532
T061;T047;T046;T190
36,229,124
divers environment perturb reveal evolut context depend genet effect gene express level increas appreci addit shape individu genotyp environ complex trait also determin poor understood interact two factor call genotyp environ ge interact remain difficult map organism level uncov use molecular phenotyp larg scale use tmseq profil transcriptom across cellular environ immort b cell line genom project map genet basi gene express level across environ reveal context depend genet architectur averag herit gene express level increas treatment relat control condit averag treatment reveal new express quantit trait loci eqtl gene across experi identifi eqtl context depend group enrich trait diseas associ loci evolutionari analys suggest posit select shape ge loci involv respond immun challeng hormon man made chemic hypothes reflect reduc opportun select act respons molecul recent introduc human environ togeth work highlight import consid exposur evolutionari histori studi interpret ge interact provid new insight evolutionari mechan maintain ge loci human popul
D040641;D059467
T081;T086;T028