PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,229,122 | guid medit hypnosi whole person health whole person holist health deal mind bodi spirit connect unifi domain balanc whole person health make possibl cell tissu fluid balanc diseas come back balanc person heal ill automat pattern recognit interrupt system facilit rapid chang peopl freed subconsci mind constraint goal modern transform health care system combin best convent care whole person health produc best health care planet | D006990;D019122 | T061;T041 |
36,229,121 | parent train adapt need children callous unemot trait random control trial callous unemot cu trait design distinct subgroup children earli start stabl aggress conduct problem critic tradit parent intervent often fail normal conduct problem among subgroup aim studi test whether parent child interact therapi pcit adapt target distinct deficit associ cu trait pcit cu produc superior outcom relat standard pcit proof concept trial famili year old child age year sd male clinic signific conduct problem elev cu trait random receiv standard pcit n pcit cu n urban univers base research clinic famili complet five assess measur child conduct problem cu trait empathi parent condit report good treatment accept signific improv conduct problem cu trait activ treatment group differ howev linear mix effect model show treatment gain conduct problem deterior children standard pcit relat pcit cu month follow period ds pcit cu show promis sustain improv conduct problem young children conduct problem cu trait requir continu follow refin | D019955 | T048 |
36,229,120 | childhood predictor long term tic sever tic impair tourett disord tic peak late childhood declin adolesc yet tourett disord tic persist adulthood evalu childhood predictor adult tic sever tic impair chang time eighti adolescentsadult evalu year follow random control trial behavior therapi independ evalu rate tic sever tic impair baselin posttreat long term follow baselin parent complet demographicsmed histori youth tic intern extern symptom rate youth rate premonitori urg sever famili function control prior tic treatment effect femal sex higher tic sever predict higher tic sever adulthood femal sex stimul medic use higher tic sever poorer famili function predict higher tic impair higher tic sever premonitori urg sever predict smaller reduct tic sever wherea higher extern symptom predict greater reduct tic sever femal sex predict smaller reduct tic impair extern symptom predict greater reduct tic impair femal sex childhood tic sever import predictor tic sever tic impair adulthood famili function premonitori urg sever tic sever import modifi target earli target intervent improv long term outcom | D013981;D020323;D005879 | T047;T184;T037;T048 |
36,229,119 | accept feasibl intervent enhanc social group belong evid three trial group health group health gh group psychotherapi program target social group disconnect emerg evid base support efficaci reduc loneli depress social anxieti howev date formal analysi accept client therapist investig feasibl wider implement input end user crucial ensur program wider suitabl contribut improv studi drew data three clinic trial includ gh client gh therapist phase iii trial addit data avail client dose control cognit behavior therapi cbt comparison group focus groupsinterview therapist client client satisfact high averag rate signific exceed cbt comparison group therapist satisfact modul retent homework complet high client say attempt homework therapist client emphas benefit aris gh contribut group context vehicl achiev posit outcom | D015928;D011615 | T061 |
36,229,118 | support transdiagnost motiv model self damag behavior compar salienc motiv bing drink disord eat nonsuicid self injuri integr across motiv model suggest differ self damag behavior sdbs enact similar reason howev remain unclear whether motiv relev certain sdbs other answer question present studi compar salienc potenti share motiv across exemplar sdbs select repres differ point along intern extern spectra bing drink disord eat bing eat purg fast nonsuicid self injuri nssi seven hundr four first year univers student femal age complet month survey assess engag motiv sdbs motiv conceptu either interperson bond other conform other communic strength communic distress reduc demand intraperson reduc negat emot enhanc posit emot punish oneself multilevel model compar endors motiv across sdbs result reveal sdbs motiv similar goal albeit differ degre although except emerg interperson motiv salient bing drink follow disord eat nssi contrast intraperson motiv salient nssi follow disord eat bing drink motiv differ also found within disord eat exampl punish oneself relev purg fast bing eat wherea reliev negat emot relev bing eat purg fast similar dimension model posit sdbs intern extern spectra salienc motiv bing drink nssi may fall distinct spectra ie interperson intraperson respect motiv disord eat exhibit element consist spectra studi support common motiv framework investig potenti treat varieti topograph distinct sdbs | D063425;D056912;D001068;D016728 | T055;T047;T048 |
36,229,117 | therapist support need compar therapist self guid internet base cbt somat symptom distress isoma emerg adult persist somat symptom vari etiolog common emerg adult lead distress impair internet deliv intervent could help prevent burden chronic persist somat symptom studi investig impact therapist guidanc effect cognit behavior internet intervent somat symptom distress isoma emerg adult secondari analysi two arm random control trial includ univers student femal yrs vari degre somat symptom distress either alloc week intervent regular written therapeut guidanc isoma guid control group waitlist afterward cross receiv isoma guidanc demand isoma god primari outcom somat symptom distress assess phq psychobehavior symptom somat symptom disord assess ssd pre post treatment secondari outcom includ depress anxieti disabl treatment show statist signific pre post improv primari isoma guid isoma god secondari outcom howev intent treat analysi reveal non signific group effect outcom ps control confound variabl effect size margin overal find indic internet deliv cognit behavior therapi regular guidanc unequivoc superior guidanc demand allevi somat symptom distress associ psychopatholog emerg adult next step non inferior studi need test robust find impact clinic popul | D015928;D000079382;D000071896 | T061;T058;T184 |
36,229,116 | random trial identifi accur measur method adher cognit behavior therapi clinician fidel cognit behavior therapi cbt import mechan desir clinic outcom achiev indic care qualiti despit import fidel measur method effici demonstr reliabl valid use random trial design compar three method assess cbt adher core compon fidel direct observ gold standard clinician recruit communiti mental health agenc n age year sd femal random one three fidel condit self report n chart stimul recal semistructur interview chart avail n behavior rehears simul role play n particip clinician complet fidel assess three session three differ client recruit clinician caseload n age year sd femal session also audio record code comparison determin accur method fidel measur parallel scale yield adher maximum score ie highest rate intervent session mean techniqu observ count total observ techniqu result three level mix effect regress model indic behavior rehears produc compar score observ adher score ps indic differ behavior rehears observ self report chart stimul recal overestim adher compar observ ps overal find suggest behavior rehears index cbt adher compar direct observ gold standard pediatr popul behavior rehears may time abl replac need resourc intens direct observ implement research practic | D015928 | T061 |
36,229,115 | promot posit relationship parent grandpar random control trial group tripl p plus compass vietnam vietnames cultur grandpar signific involv upbring grandchildren involv grandpar entail lot ambigu challeng boundari parent grandpar often unclear communic restrict due power differenti lead inconsist disciplin studi seek evalu efficaci group tripl p posit parent program plus build copar allianc compass focus modul promot parent grandpar relationship one hundr vietnames parent whose parent parent law provid care children random assign either intervent condit n waitlist control condit n group assess three time point pre intervent post intervent month follow short term intervent effect found across domain includ co parent conflict parent self compass dysfunct parent parent self efficaci parent adjust child behavior problem child prosoci behavior intervent effect co parent conflict parent behavior child prosoci behavior maintain month follow studi demonstr efficaci tripl p plus compass promot co parent relationship parent grandpar enhanc parent practic child outcom vietnames famili | D000066502 | T099 |
36,229,114 | longitudin associ among servic member ptsd symptom partner accommod partner distress romant partner accommod trauma survivor posttraumat stress disord ptsd symptom eg particip avoid safeti behavior express one thought feel putat mechan link ptsd symptom partner distress hypothesi never empir test current studi investig propos within coupl mediat process servic member ptsd symptom partner depress symptom relationship satisfact partner accommod well coupl associ among construct possibl moder role partner conflict avoid helpless cah motiv accommod servic member ptsd symptom examin question male servic memberfemal civilian coupl assess four time month period use multipl group version random intercept cross lag panel model within coupl servic member higher level ptsd symptom one time point signific predict partner accommod next time point turn signific predict higher level partner depress symptom subsequ time point predict partner subsequ relationship satisfact coupl level partner accommod signific posit associ partner depress symptom among endors high cah motiv accommod r addit accommod signific negat associ partner relationship satisfact regardless cah motiv level rs find discuss light potenti coupl base treatment ptsd enhanc partner individu relat well | D013313 | T048 |
36,229,113 | behavior experi intoler uncertainti random clinic trial adult general anxieti disord sophist multicompon treatment adult general anxieti disord gad develop past three decad although comprehens treatment produc encourag result appear less efficaci treatment anxieti disord goal random control trial test newli develop high focus treatment adult gad behavior experi intoler uncertainti sixti particip women men mean age year rang year random either treatment n wait list control n treatment consist week hour session particip learn use behavior experi test catastroph belief uncertainti assess conduct pre mid postcondit month follow primari outcom sever gad secondari outcom worri depress somat anxieti intoler uncertainti use growth curv model found treatment group superior wait list group term chang pre posttest outcom combin sampl wait list particip receiv treatment evidenc larg signific decreas outcom treatment gain either maintain increas month follow period studi new treatment promis treatment option adult gad consid may efficaci comprehens evid base psycholog treatment gad | D015928 | T061 |
36,229,112 | cognit behavior versus support psychotherapi intermitt explos disord random control trial clinic trial evalu efficaci psychotherapi intermitt explos disord ie present studi test efficaci cognit behavior intervent versus support psychotherapi among adult ie random clinic trial particip ie men women age year complet twelv minut individu session either multi compon cognit behavior intervent ie n time equat support psychotherapi n baselin posttreat month follow particip receiv overt aggress scale modifi conduct interview blind particip studi condit visit particip also complet self report measur relat aggress self report relat aggress social behavior anger state trait anger express inventori cognit bias eg social inform process questionnair attribut emot respons questionnair associ symptom eg beck depress inventori primari studi outcom aggress behavior anger though particip treatment tend improv time cognit behavior intervent superior support psychotherapi decreas aggress behavior relat aggress find support efficaci multicompon cognit behavior intervent treat aggress ie | D007174 | T048 |
36,229,111 | assess psycholog inflex pertain self patient posttraumat stress disord use indirect measur nonassoci proposit relat frame theori rft modern behavior account human languag cognit focus relat proposit rather associ core explanatori construct attempt measur proposit rft research develop implicit relat assess procedur irap argu size irap effect may provid metric psycholog inflex current studi aim determin whether psycholog inflex measur self focus natur languag irap nl irap would higher clinic sampl individu diagnosi ptsd n compar nonclin sampl subsequ studi investig whether self focus nl irap could use predict presenc clinic diagnosi use roc analysi predict higher level psycholog inflex observ clinic group self focus nl irap also correct classifi presenc ptsd auc sensit level specif level overal use irap nonassoci clinic measur appear promis | D013313 | T048 |
36,229,110 | adolesc experi co occur social anxieti adhd symptom link social skill interact unfamiliar peer confeder adolesc elev social anxieti common experi peer relat impair particular age unfamiliar peer stem avoid behavior yet peer relat impair uniqu social anxieti exampl adolesc experi social anxieti may also experi symptom attent deficithyperact disord adhd also increas risk peer relat impair relat social anxieti peer relat impair link adhd symptom like stem hyperact ie approach behavior distinct pathway point adolesc elev social anxieti adhd symptom ie social anxieti adhd experienc particular high peer relat impair common manifest behavior display low social skill interact unfamiliar peer test notion mix clinicalcommun sampl year old adolesc parent adolesc particip seri social interact task design simul adolesc interact age unfamiliar peer train observ independ rate adolesc observ social skill within interact parent adolesc complet parallel survey social anxieti adhd symptom use identifi social anxieti adhd adolesc well combin social anxieti adhd symptom ie neither elev one adolesc social anxieti adhd display signific lower social skill relat group among adolesc social anxieti adhd may compound effect social skill therapist work social anxieti adhd adolesc probe peer relat impair factor implic develop mainten impair | D001289 | T048 |
36,229,109 | examin rdoc negat valenc system domain construct self report unit analysi respons shortcom current diagnost classif system mental health disord poor valid reliabl categor diagnos nation institut mental health propos research domain criteria rdoc initi move toward dimension approach use translat research current studi examin associ measur behavior cognit mental health symptom overlap negat valenc system nvs domain specif examin self report unit analysi reflect rdoc nvs construct acut threat potenti threat sustain threat frustrat nonreward loss overal goal identifi addit self report measur reflect construct particip two student sampl two communiti sampl total n complet onlin self report measur questionnair total subscal score submit princip axi factor analysi promax rotat separ sampl student sampl one communiti sampl six factor solut emerg reflect major aspect rdoc nvs posit valenc system particular acut threat ie fearpan potenti threat ie inhibitionworri sustain threat ie chronic stress loss ie low well frustrat nonreward ie reactiv aggress reduc behavior activ second communiti sampl differ fearpan frustrationang combin general distress factor recommend addit nvs self report marker discuss | D001007;D005239 | T041;T184;T048 |
36,229,108 | treatment seek anxieti depress among black adult multilevel empir inform psycho sociocultur model black adult anxieti andor depress disord underutil outpati psychotherapi pharmacolog treatment compar white adult notabl anxieti depress disord tend chronic black individu disord experi greater function impair white individu document racial dispar mental health treatment initi indic need research address cultur specif barrier treatment review paper critic evalu exist theoret model treatment seek among black adult inform novel integr cultur contextu model model extend previous one incorpor factor relev treatment seek among black adult eg racial ident perceiv discrimin medic mistrust critic examin factor intersect key factor three level influenc treatment seek process individu level communiti level societ level posit interact among factor three level influenc may impact treatment seek decis among black adult model inform suggest enhanc intervent design support outpati servic use among black adult | D003863;D035502 | T054;T184;T048 |
36,229,106 | assess coronari arteri aortic calcif patient prostat cancer use f sodium fluorid petcomput tomographi aim studi assess coronari arteri aortic calcif healthi control angina pectori patient prostat cancer patient use f sodium fluorid petcomput tomographi naf petct retrospect analysi compar prostat cancer patient healthi subject patient angina pectori increas target background ratio tbr coronari arteri ascend aorta aortic arch descend aorta observ cancer patient compar healthi control compar angina pectori patient result demonstr feasibl assess vascular microcalcif naf petct signific differ uptak accord comorbid | D003324;D011471 | T191;T047 |
36,229,105 | feasibl global assess bone metastas prostat cancer f sodium fluorid petcomput tomographi f sodium fluorid naf petcomput tomographi ct allow detect bone metastas patient prostat cancer pca aim studi test feasibl assess global metastat bone diseas patient pca use threshold base pet segment techniqu retrospect analysi perform patient pca known bone metastas underw naf petct imag adapt contrast orient threshold techniqu use segment naf avid lesion mean metabol volumetr product mvpmean partial volum correct mvpmean cmvpmean metabol activ volum mav calcul lesion valu sum within patient obtain global pet diseas burden pearson correl analysi use assess associ global naf petct metric clinic biomark metastat diseas activ global mvpmean cmvpmean mav signific correl alkalin phosphatas alp level p correl observ global naf petct measur prostat specif antigen psa level global assess feasibl method quantifi metastat bone diseas activ patient pca converg valid support demonstr signific correl naf petct paramet blood alp level | D001859;D011471 | T191 |
36,229,104 | prostat cancer imag f fluciclovin f fluciclovin pet approv evalu patient suspect prostat cancer recurr f fluciclovin pet high specif local extraprostat diseas even negat convent imag low prostat specif antigen report influenc patient manag improv outcom recent food drug administr approv prostat specif membran antigen psma pet f fluciclovin like use adjunct modal patient suspect occult local recurr andor negat psma find | D003503;D011471 | T191;T109 |
36,229,103 | ga prostat specif membran antigen petct imag clinic perspect prostat cancer imag clinic perspect prostat cancer imag prostat cancer becom increas import time incid prostat cancer rise better screen techniqu emerg develop person system therapi highlight unmet need whole bodi imag prostat specif membran antigen psma pet eas perform mechan local prostat tumor cell emerg prefer modal diagnosi stage treatment respons assess context psma pet help map diseas extent skelet viscer spread plan target therapeut approach | D000072078;D011471 | T191;T060 |
36,229,102 | f label radiotrac prostat specif membran antigen histor perspect futur direct much modern growth nuclear medicin driven pet imag prostat specif membran antigen psma men prostat cancer fluorin ideal pet radionuclid moder long half life high positron yield low positron energi cyclotron base product f dcfpyl first food drug administr approv compound class review cover number aspect radiofluorin psma pet agent includ histor develop earli clinic trial key multicent registr trial emerg clinic agent new compound enter human use futur direct field | D011467;D011471 | T191;T023 |
36,229,101 | role mri ultrasound comput tomographi manag prostat cancer comput tomographi ct mri ultrasound play evolv role prostat cancer manag multi parametr mri high sensit negat predict valu prostat cancer diagnosi lead increas util part activ surveil paradigm low intermedi risk patient local tumor stage high grade cancer ct modest sensit stage high grade tumor evalu nodal liver lung bone metastasi prefer assess treatment relat complic recent ultrasound limit guidanc modal biopsi treatment howev advanc micro ultrasound technolog aim expand role diagnos manag prostat cancer | D011471 | T191 |
36,229,093 | advanc multimod imag cardio oncolog jacc state art review popul patient cancer rapid expand diagnosi monitor cardiovascular complic great reli imag numer advanc field cardio oncolog imag occur recent year review present updat practic approach multimod cardiovascular imag cardio oncolog patient provid recommend imag detect myriad advers cardiovascular effect associ antineoplast therapi cardiomyopathi atherosclerosi vascular toxic myocard valv diseas cardiac mass uniqu address role cardiovascular imag patient pre exist cardiomyopathi pregnant patient long term survivor popul limit resourc also address futur avenu investig opportun artifici intellig applic cardio oncolog imag review provid uniform practic approach cardiovascular imag patient cancer | D000970;D002318;D064420;D006331;D009369 | T047;T046;T037;T121;T191;T109 |
36,229,091 | impact clonal hematopoiesi patient cardiogen shock complic acut myocardi infarct clonal hematopoiesi indetermin potenti chip common elder individu associ increas risk hematolog malign cardiovascular diseas impact chip outcom patient cardiogen shock cs complic acut myocardi infarct ami remain undetermin | D009203;D062645 | T061;T047 |
36,229,089 | dose respons sacubitrilvalsartan patient heart failur reduc eject fraction dose sacubitrilvalsartan sacval achiev clinic trial heart failur reduc eject fraction hfref often reach clinic practic | D000613;D001713;D006333;D000068756;D018487 | T047;T046;T116;T121;T109 |
36,229,087 | intens blood pressur lower patient malign left ventricular hypertrophi left ventricular hypertrophi lvh combin elev cardiac biomark reflect myocardi injuri neurohormon stress malign lvh associ high risk heart failur death | D006333;D006973 | T047;T046 |
36,229,085 | long term chang cardiac structur function follow bariatr surgeri studi short term follow demonstr favor effect weight loss wl heart littl inform avail regard long term effect effect viscer fat reduct | D050110 | T061 |
36,229,084 | continu progress field two dimension correl spectroscopi cos part iii versatil applic review comprehens summari two dimension correl spectroscopi cos last two year cover remark applic cos divers field use mani type probe perturb last two year highlight ir spectroscopi still popular probe cos last two year applic fluoresc raman spectroscopi also popular use extern perturb appli cos variat concentr ph relat composit dramat increas last two year temperatur still use effect slight decreas compar two year ago cos appli divers system environ natur product polym food protein peptid solut mixtur nano materi pharmaceut other especi biolog environment applic signific emerg survey review paper show cos activ evolv expand field | D001688;D011506 | T121;T123;T116 |
36,229,077 | myometr pelvic septic vein thrombophleb secondari fusobacterium necrophorum sepsi young woman present fever abdomin pain malodour vagin discharg found septic shock set recent medic abort subsequ intrauterin devic placement blood cultur grew fusobacterium necrophorum despit appropri antibiot therapi fever fail defervesc subsequ evalu reveal septic thrombophleb right gonad vein branch right iliac vein improv prolong cours target antimicrobi therapi | D005674;D000292;D018805;D018461;D013924 | T047;T046 |
36,229,076 | combin strategi initi clozapin refractori schizophrenia patient low neutrophil level clozapin drug confirm efficaci refractori schizophrenia howev use restrict due risk potenti life threaten side effect agranulocytosi although restrict ensur safeti haematolog risk patient refractori schizophrenia low neutrophil level may miss opportun receiv clozapin treatment herein report case patient refractori schizophrenia low neutrophil level success initi clozapin treatment use sever method increas neutrophil level strategi consist discontinu antipsychot treatment lithium carbon adenin light exercis blood test combin procedur may effect option treatment patient refractori schizophrenia whose neutrophil level suffici initi clozapin | D014150;D003024;D012559 | T121;T048;T109;T039 |
36,229,075 | trf use noncanon function tfiih promot telomer replic telomer dna challeng replisom requir trf effici duplic trf recruit blm helicas blm loss explain extens telomer fragil atr signal sister telomer associ stas induc trf delet document helix trfh domain helix myb domain trf requir effici telomer replic mutat helic generat trf separ function mutant trf eklw ti induc sever telomer replic defect atr signal stas identifi transcript nucleotid excis repair ner factor tfiih critic effector trf loss tfiih subunit ner factor caus telomer replic phenotyp trf eklw ti mutant independ effect trf express tfiih subunit coimmunoprecipit wild type trf trf eklw ti result establish major mechan trf ensur telomer replic involv noncanon function tfiih | D035321;D016615 | T026;T123;T116 |
36,229,073 | interprofession survey medic reconcili activ us depart veteran affair develop valid implement readi questionnair medic reconcili mr detect medic histori discrep interfac care help avoid downstream advers drug event howev organis struggl implement high qualiti mr programm literatur identifi system barrier includ technolog capabl data interoper howev organis cultur root caus underexplor | D059065;D014728 | T098;T058 |
36,229,071 | domin negat mitofusin caus mitochondri perinuclear cluster aberr tether vertebr mitochondri outer membran fusion mediat two mitofusin paralog mfn mfn conserv dynamin superfamili protein character variant mitofusin report patient cmta serin replac prolin mfn sp equival mfn sp serin hing domain hing connect globular gtpase domain adjac extend helic bundl find express variant result prolif stabl mitochondri tether also block mitochondri fusion endogen wild type mitofusin format mitochondri perinuclear cluster cmta variant requir normal gtpase domain function format mitofusin complex across two membran propos conform dynam mediat hing regul gtp hydrolysi disrupt substitut prolin ss prevent progress tether membran fusion thus data consist model mitofusin mediat membran fusion hing support power stroke progress tether complex membran fusion | D033681;D024101 | T123;T116 |
36,229,065 | whole exom sequenc epitheli ovarian carcinoma differ resist platinum therapi epitheli ovarian carcinoma eoc high fatal risk resist therapi recurr perform whole exom sequenc blood tumor tissu pair patient surgic resect eoc compar sensit patient platinum resist patient signific higher somat mutat rate tp lower sever gene hippo pathway confirm pivot role somat mutat homolog recombin repair gene platinum sensit favor prognosi eoc patient implement germlin homolog recombin repair profil signific improv predict addit distinct mutat signatur exampl sbs overal mutat load somat mutat pabpc pabpc tfam co segreg resist status high grade serous carcinoma subtyp overal surviv patient generat germlin somat genet landscap prognost differ subgroup eoc patient follow studi focus util observ associ precis oncolog | D010051;D010984 | T191;T196 |
36,229,064 | autoimmun rna dysregul seizur therapeut prospect neuropsychiatr lupus lupus autoimmun frequent present neuropsychiatr manifest under etiolog remain poor understood human brain cytoplasm rna bc rna translat regul neuron synapto dendrit domain show bc guanosin adenosin dendrit transport motif recogn autoantibodi subset neuropsychiatr lupus patient autoantibodi impact bc function quasi irrevers displac two rna transport factor guanosin adenosin transport motif anti bc autoantibodi gain access brain neuropsychiatr lupus patient give rise clinic manifest includ seizur establish causal naiv mice permeabil blood brain barrier inject anti bc autoantibodi lupus patient seizur anim inject develop seizur suscept high mortal seizur activ entir preclud anim inject lupus anti bc autoantibodi togeth bc decoy autoantigen seizur common clinic manifest neuropsychiatr lupus work identifi anti bc autoantibodi activ mechanist caus result demonstr potenti util bc decoy autoantibodi specif therapeut intervent neuropsychiatr lupus | D020945 | T047 |
36,229,063 | high resolut structur fish aquaporin reveal novel extracellular fold aquaporin protein channel embed lipid bilay cell organ earth crucial water homeostasi fish aquaporin believ import osmoregul howev molecular mechan behind poor understood present first structur function character fish aquaporin cpaqpaa fresh water fish climb perch anaba testudineus speci high osmoregulatori interest abil spend time seawat land studi show cpaqpaa water specif aquaporin uniqu fold extracellular side result constrict region function analysi combin molecular dynam simul suggest phosphoryl two site caus structur perturb region may implic channel gate extracellular side | D020346;D008051 | T026;T123;T116 |
36,229,057 | post acut sequela covid six month infect popul base studi describ symptom symptom cluster post covid syndrom six month acut infect describ risk factor examin associ symptom cluster general health work capac | D000086382 | T047;T067 |
36,229,043 | dendrit self assembl structur therapeut charg pentapeptid cre n ka cys arg n glu lys ala n glu refer n methyl glu anti cancer pentapeptid induc prostat tumor necrosi signific reduct tumor growth engin increas resist endogen proteas parent peptid creka cys arg glu lys ala consid high tendenc aggreg self assembl cre n ka creka well defin order structur examin function peptid concentr ph spectroscop studi atomist molecular dynam simul reveal signific differ secondari structur creka cre n ka thus restrict impos n glu residu reduc conform variabl cre n ka respect creka signific affect format well defin order self assembl morpholog aggreg poor defin morpholog obtain solut low moder creka concentr ph wherea well defin dendrit microstructur fractal geometri obtain cre n ka solut similar peptid concentr ph format dendrit structur propos follow two step mechan pseudo spheric particl pre nucleat diffus limit aggreg process pre defin dendrit geometri pre nucleat structur coalesc incorpor conform restrain cre n ka molecul solut surfac form continu dendrit structur instead regular assembl obtain solut high peptid concentr dynam domin strong repuls peptid peptid electrostat interact solut ph total peptid charg zero overal result demonstr dendrit structur obtain molecular charg cre n ka control ph favor kinet thermodynam self assembl process | D010455;D056004 | T121;T044;T066;T116 |
36,229,032 | evalu bivalirudin dose pediatr extracorpor membran oxygen renal insuffici renal replac therapi bivalirudin offer sever import advantag relev manag extracorpor membran oxygen ecmo patient multicent retrospect analysi evalu bivalirudin dose pediatr ecmo correl dose sever renal dysfunct total patient includ analys estim glomerular filtrat rate egfr mlmin n egfr n egfr mgkghr patient rrt mgkghr patient egfr mgkghr patient egfr rrt progress dose escal two threefold increas requir maintain therapeut rang initi day ecmo coincid improv renal creatinin clearanc time period establish initi start dose bivalirudin conting upon egfr essenti rapid achiev target anticoagul intens dose adjust guid laboratori monitor necessari given dynam chang creatinin clearanc follow ecmo initi | D015199;D051437 | T061;T047 |
36,229,018 | left liver graft adult adult live donor liver transplant optim portal flow modul strategi overcom small size syndrom retrospect cohort studi adult adult live donor liver transplant ldlt notabl type liver transplant sever center prefer right liver graft rlg left liver graft llg better recoveri recipi compar outcom donor recipi ldlt use llgs rlgs | D019520;D016031 | T098;T061 |
36,229,006 | nts cea project modul depress like behavior mous model chronic pain depress symptom comorbid chronic pain common health problem under neural circuit mechan remain elus identifi glutamaterg project nucleus solitari tract nts central nucleus amygdala cea mediat depress like behavior chemotherapi induc neuropath pain model inhibit ablat glutamaterg nts neuron allevi depress hypersensit behavior mice project neuron form excitatori synaps somatostatin express neuron cea silenc nts cea project allevi depress hypersensit behavior wherea activ proection promot depress behavior addit nave mice activ nts cea project induc obvious depress behavior block silenc cea somatostatin express neuron togeth reveal modulatori role nts glutamaterg project cea circuit modul depress like behavior comorbid chronic pain | D017552;D059350 | T023;T184;T047 |
36,228,995 | ultrast shell pfc nanobubbl platform ultrasound assist diagnost therapi nanoscal echogen bubbl nbs use theranost platform local deliveri encapsul drug howev generat nbs challeng lifetim short millisecond solut aim work optim prepar method generat stabl nbs character measur acoust effici b nano size ensur passiv tumour target c stabil storag inject abil entrap drug nbs monodispers ultra stabl stabil achiev generat amphiphil multilamellar shell abl effici retain pfc gas nbs perform good acoust enhanc wide frequenc rang reson condit test vitro vivo experi prove potenti platform product versatil carrier use ultrasound assist diagnost therapeut theranost applic | D000162;D045423 | T074;T070 |
36,228,928 | neuroimag genet oxytocin transcriptom inform systemat review last coupl decad wit rapid accumul studi implic oxytocin ot sever neurobiolog underpin human behaviour impair psychiatr ill specif neuroimag genet approach help elucid impact variat ot pathway gene human brain review provid first systemat account discuss previous find aris human neuroimag epi genet studi ot relat gene improv mechanist interpret find use data genotyp tissu express project explor function impact genet variat may human transcriptom result provid date summari brain circuit found impact ot relev epi genet variabl map brain pathway link ot gene diseas highlight sever epi genet factor modul brain respons intranas ot final provid suggest believ might improv futur research field | D010121;D059467 | T116;T086;T081;T121;T125 |
36,228,927 | non rem sleep electrophysiolog rem sleep behaviour disord narrat mini review isol rapid eye movement sleep rem behaviour disord irbd prodrom sign neurodegen disord empir find point role non rem nrem sleep alter neurodegen process therefor interest nrem sleep electroencephalographi eeg irbd progress increas present review aim provid updat state art nrem sleep electrophysiolog irbd first describ find nrem eeg power spectra consid specif nrem sleep eeg hallmark ie slow wave slow oscil k complex sleep spindl final focus nrem sleep instabl review literatur small heterogen rapid grow consist find point alter sleep spindl cyclic altern pattern rbd larger discrep character result slow wave activ recent studi use topograph approach provid promis result evid relationship nrem sleep alter neurodegen process irbd well longitudin chang scarc discuss main methodolog limit highlight possibl futur direct | D020187 | T048 |
36,228,926 | boundless behavior neurosci look across year thirti year sinc two inaugur ibn presid sat larger neurosci confer decid behavior neurosci singl theme meet progeni convers intern behavior neurosci societi ibn year thirti year anniversari reflect back last thirti year research career societi second presid paul r sanberg exampl behavior neurosci research chang last decad | D009488;D005879 | T047;T091 |
36,228,925 | stress hormon shape memori fear anxieti human stress hormon influenc process fear anxieti relat memori mechan exampl modul consolid retriev process associ emot episod memori fear extinct learn review summar recent laboratori find time depend effect stress extinct learn extinct retriev furthermor relat experi clinic intervent approach reli extinct process exposur therapi benefici effect administr stress hormon cortisol observ modul extinct base intervent differ find obtain reconsolid manipul procedur util restabil retriev reactiv memori case blockad adrenerg beta receptor reconsolid fear stimulus might repres promis intervent substanti progress made understand interact stress hormon memori process associ fear anxieti potenti enhanc therapeut success prevent relaps long run | D005108;D007171 | T061;T041 |
36,228,924 | stress make us less prosoci systemat review meta analysi effect acut stress prosoci behaviour use econom game prosoci behaviour fundament social togeth yet acut stress common everyday occurr influenc behaviour toward one anoth still unclear systemat review meta analysi aim quantit investig effect experiment induc acut stress prosoci behaviour econom game also probe possibl moder explain differ find includ studi individu effect particip meta analysi found overal differ stress control group prosoci behaviour smd cost punish smd moder effect stressor type particip gendersex delay stressor task howev potenti recipi donat money person vs chariti complex decis reveal differ stress result meta analysi suggest current clear answer question whether stress increas decreas prosoci highlight import open question suggest field go next | D012919;D000533 | T054 |
36,228,923 | decad progress acceler malaria control mali evid west africa intern center excel malaria research articl highlight decad signatur achiev west africa intern center excel malaria research wa icemr partner toward guid malaria prevent control strategi sinc wa icemr perform longitudin studi monitor assess malaria control intervent respect space time pattern vector transmiss indic drug resist marker activ facilit support mali nation malaria control program research activ includ larg scale activ passiv surveil expand coverag univers long last insecticid treat bed net season malaria chemoprevent smc find reveal substanti declin malaria occurr scale control intervent wa icemr studi site wa icemr studi show smc use sulfadoxin pyrimethamin plus amodiaquin high effect prevent malaria among children year age altern smc regimen dihydroartemisinin plus piperaquin shown potenti effect provid advantag accept complianc standard smc regimen find discuss articl includ higher observ multipl infect rate malaria histor high endem area continu antimalari drug sensit plasmodium falciparum high outdoor malaria transmiss rate increas insecticid resist past decad progress achiev wa icemr partner highlight critic need maintain current malaria control intervent develop novel strategi disrupt malaria transmiss enhanc evalu strategi research partnership particular need wake report artemisinin resist southeast asia east africa | D000962;D037621;D008288;D016778 | T121;T047;T109 |
36,228,922 | impact emerg need new research question aris year center studi complex malaria india center studi complex malaria india cscmi launch overal goal address major gap understand complex malaria india project epidemiolog transmiss pathogenesi diseas center mandat adopt integr approach malaria research includ build capac develop infrastructur nurtur futur malaria leader conduct relev impact studi assist india move control elimin outlin interact impact center malaria polici control counterpart india well describ emerg need new research question becom appar past year | D008288 | T047 |
36,228,921 | malaria resili south america epidemiolog vector biolog immunolog insight amazonian intern center excel malaria research network peru brazil saw rapid reemerg malaria amazonia remain import public health prioriti south america amazonian intern center excel malaria research icemr design take multidisciplinari approach toward identifi novel malaria control elimin strategi base geograph epidemiolog distinct site northeastern peruvian western brazilian amazon region synergist project integr malaria epidemiolog vector biolog immunolog amazonian icemr overarch goal understand human behavior sociodemograph featur human reservoir transmiss predomin asymptomat parasitem peopl interact major amazonian malaria vector nyssorhynchus former anophel darlingi human immun respons maintain malaria resili continu endem hypoendem set review amazonian icemr achiev synergi among malaria epidemiolog plasmodium vector interact immun respons provid roadmap research import point toward achiev malaria control elimin america | D000852;D008288 | T047;T204 |
36,228,920 | asia pacif intern center excel malaria research maxim impact malaria control polici public health cambodia papua new guinea asia pacif intern center excel malaria research icemr fund conduct coordin set field depth biolog studi cambodia papua new guinea png site span rang transmiss intens current found asia pacif region overal object gain understand key parasit human host vector factor involv maintain transmiss face intensifi control elimin program develop novel approach identifi target residu transmiss foci articl describ icemr program design address key knowledg gap prioriti area malaria control program countri png partner work togeth two consecut icemr grant present case studi partnership engag approach led stronger coordin research activ integr program inform countri level strateg plan priorit control activ set icemr program generat insight transmiss foci risk factor ongo transmiss highlight hidden burden vivax malaria need addit complementari vector control tool final summar emerg research question prioriti area name surveil vivax malaria new vector control tool communityhealth system orient approach tool develop implement research identifi need guid polici | D008288;D016780 | T047 |
36,228,919 | advanc basic translat research part center studi complex malaria india center studi complex malaria india cscmi one intern center excel malaria research fund nation institut health sinc center combin innov research capac build technolog transfer undertak studi clinic translat impact move malaria control india toward ultim goal malaria eliminationerad key element research site four state india tamil nadu gujarat odisha meghalaya undertak communiti clinic base epidemiolog project character burden malaria region demograph clinic data sampl collect studi use downstream project exampl widespread use mosquito repel popul genom plasmodium vivax serolog respons p vivax plasmodium falciparum antigen reflect past present exposur focus studi pathogenesi sever malaria caus p falciparum magnet reson imag cerebr malaria patient provid snapshot basic appli research cscmi undertaken past year indic research andor clinic translat impact studi | D008288;D016778;D016780 | T047 |
36,228,918 | impact environment modif ecolog epidemiolog pathogenesi plasmodium falciparum plasmodium vivax malaria east africa food insecur recurr famin poverti threaten health million african resid construct dam rural irrig scheme key solv problem sub saharan africa intern center excel malaria research address major knowledg gap challeng plasmodium falciparum plasmodium vivax malaria control elimin malaria endem area kenya ethiopia major invest water resourc develop take place articl highlight progress intern center excel malaria research malaria vector ecolog behavior epidemiolog pathogenesi sinc incept studi conduct four field site kenya ethiopia show dam irrig increas abund stabil product larval habitat result increas malaria transmiss greater diseas burden field studi togeth hydrolog malaria transmiss model enhanc abil predict impact water resourc develop project vector larval ecolog malaria risk therebi facilit develop optim water environment manag practic context malaria control effort intersector collabor communiti engag crucial develop implement cost effect malaria control strategi meet food secur need control malaria burden local communiti | D000852;D008288;D016778;D016780 | T047;T204 |
36,228,917 | asia pacif icemr understand malaria transmiss acceler malaria elimin asia pacif region gain depth understand malaria transmiss requir integr multifacet research approach asia pacif intern center excel malaria research icemr appli specif develop molecular immunolog assay depth entomolog assess advanc statist mathemat model approach rich seri longitudin cohort cross section studi papua new guinea cambodia reveal essenti contribut forest base transmiss particular challeng pose plasmodium vivax malaria elimin cambodia papua new guinea studi document complex host vector parasit interact under stun reduct malaria burden signific resurg transmiss describ novel analyt surveil molecular immunolog tool appli ongo asia pacif icemr research program | D008288;D016780 | T047 |
36,228,916 | east africa intern center excel malaria research summari key research find program resist immunolog surveil model malaria prism conduct malaria research uganda sinc improv understand diseas measur impact popul level control intervent countri summar key research find seri studi address routin health facil base surveil comprehens cohort studi studi molecular epidemiolog transmiss malaria evalu antimalari drug efficaci resist across countri assess insecticid resist among key find follow first found histor high transmiss area uganda combin univers distribut long last insecticid treat net llin sustain indoor residu spray ir insecticid lower malaria burden great mark resurg occur ir discontinu second submicroscop infect common key driver malaria transmiss especi school age children year third marker drug resist chang time new concern emerg marker predict resist artemisinin antimalari fourth insecticid resist monitor demonstr high level resist pyrethroid appreci impact synergist piperonyl butoxid pyrethroid suscept emerg resist carbam complet suscept malaria vector organophosph could import implic vector control intervent overal prism yield wealth inform inform research polici maker malaria burden opportun improv malaria control eventu elimin uganda continu studi concern type surveil discuss ongo | D000962;D037621;D057148;D007306;D008288;D011722 | T047;T074;T131;T121;T109 |
36,228,915 | understand intransig malaria malawi despit scale intervent malaria past decad diseas remain lead threat health malawi evalu epidemiolog plasmodium falciparum infect malaria diseas malawi intern center excel malaria research icemr develop implement divers robust surveil research project descript studi icemr phase increas understand declin effect long last insecticid net llin role school age children malaria parasit transmiss complex host parasit interact lead diseas find inform design icemr phase test hypothes llin use effect vector resist insecticid demograph target malaria control pattern caus asymptomat life threaten diseas impact rts vaccin plus piperonyl butoxid treat llin infect diseas young children investig help us understand mosquito human human mosquito transmiss context malawi intransig malaria problem | D057148;D007306;D008288 | T047;T074;T131 |
36,228,914 | malaria research tailor control elimin strategi greater mekong subregion malaria landscap greater mekong subregion experienc drastic chang ramp control effort reveal formid challeng slow progress toward malaria elimin problem border malaria cross border malaria introduct multidrug resist plasmodium falciparum persist plasmodium vivax asymptomat parasit reservoir insecticid resist primari vector requir integr strategi tailor individu nation region recognit challeng need research southeast asian intern center excel malaria research establish network research stakehold conduct basic translat research identifi exist emerg problem develop new countermeasur instal comprehens diseas vector surveil system sentinel site border area implement passiveact case detect cross section survey allow time detect manag malaria case provid updat knowledg effect vector control measur facilit efficaci studi antimalari incorpor sensit molecular diagnosi expos signific asymptomat parasit reservoir sustain transmiss help establish necessari evid guid target control elimin residu transmiss addit program develop point care diagnost monitor qualiti artemisinin combin therapi deliv need inform drug regulatori author take measur falsifi substandard antimalari acceler malaria elimin program activ engag stakehold level foster vertic horizont collabor enabl effect dissemin research find | D000962;D037621;D008288;D016778 | T121;T047;T109 |
36,228,913 | polici implic southern central africa intern center excel malaria research ten year malaria control impact assess hypo meso holoendem transmiss zone zambia zimbabw intern center excel malaria research icemr establish nation institut allergi infecti diseas decad ago provid multidisciplinari research support malaria control program worldwid oper endem area contribut technolog expertis ultim polici guidanc malaria control elimin southern central africa icemr conduct research across three main site zambia zimbabw differ ecolog entomolog transmiss intens control strategi scientif find led new polici action nation malaria control program partner select method materi time locat case manag vector control malaria risk map predict model case detect furnish icemr inform malaria elimin program southern zambia time seri analys entomolog parasitolog data motiv sever major chang indoor residu spray campaign northern zambia along zimbabw mozambiqu border tempor geospati data current inform investig recent resurg malaria icemr find pertain parasit mosquito genet human behavior clinic epidemiolog similar yield immedi long term polici implic site often generaliz conclus icemr program therebi provid rigor scientif investig analys nation control elimin program without impedi malaria control potenti solut would remain understudi | D008288;D000072138 | T047;T204 |
36,228,911 | malawi icemr malaria research interact result influenc health polici practic malaria remain threat public health malawi well acknowledg malaria research robust evid impact malaria polici practic result posit popul health gain report polici relev research contribut malawi intern center excel malaria research icemr partnership local intern collabor made find icemr studi shown long last insecticid treat bed net llin impregn piperonyl butoxid reduc mosquito blood feed compar convent llin hand show llin maintain end year life span older net less effect result support polici chang decis malawi nation malaria control program switch convent llin piperonyl butoxid llin conduct mass llin distribut campaign everi year studi epidemiolog pattern malaria infect show school age children higher malaria infect rate lower use control measur compar younger children adult find ad evid base influenc nation malaria control program endors school base malaria intervent part nation polici research support malawi icemr contribut countri polici decis implement evid base intervent long term studi intend continu provid practic polici relev evid necessari ultim elimin malaria infect malawi | D057148;D008288 | T047;T074 |
36,228,910 | divers malaria present across nation institut health south asia intern center excel malaria research site india malaria evolut south asia mesa intern center excel malaria research icemr establish us nation institut health us nih one malaria research center endem countri year hospit base field base work india mesa icemr document chang epidemiolog transmiss malaria four differ part india malaria evolut south asia icemr activ collabor indian partner carri broad themat area malaria case surveil vector biolog transmiss antimalari resist pathogenesi host respons program integr insight surveil field studi novel basic scienc studi two prong approach determin biolog behind diseas pattern seen field generat new relev biolog question malaria test field malaria evolut south asia icemr activ inform local intern stakehold current status malaria transmiss select part south asia includ updat region vector transmiss local parasit communiti survey new laboratori tool help monitor ongo effort control elimin malaria key region south asia includ state evolv antimalari resist differ part india new host biomark recent infect molecular marker pathogenesi uncompl sever malaria | D000962;D008288 | T121;T047 |
36,228,909 | multidisciplinari investig sustain malaria transmiss greater mekong subregion cours malaria elimin greater mekong subregion gms malaria epidemiolog experienc drastic spatiotempor chang residu transmiss concentr along intern border rise predomin plasmodium vivax emerg plasmodium falciparum parasit resist artemisinin partner drug render artemisinin base combin therapi less effect potenti spread multidrug resist parasit elicit concern vector behavior chang insecticid resist reduc effect core vector control measur recognit problem southeast asian intern center excel malaria research icemr conduct multidisciplinari research determin human migrat antimalari drug resist vector behavior insecticid resist sustain malaria transmiss intern border effort allow us comprehens understand ecolog border malaria transmiss develop popul genom tool identifi track parasit introduct addit employ vivo vitro molecular approach monitor emerg spread drug resist parasit also use genom genet method reveal novel mechan antimalari drug resist parasit also use omic popul genet approach studi insecticid resist malaria vector identifi chang mosquito communiti structur vectori potenti season dynam collect scientif find icemr research activ offer systemat view factor sustain residu malaria transmiss identifi potenti solut problem acceler malaria elimin gms | D000962;D037621;D008288;D016778 | T121;T047;T109 |
36,228,908 | west africa icemr partnership guid polici improv malaria prevent control mali nation malaria control program nmcp recent establish phase set goal elimin malaria mali past decad scale nmcp led malaria control intervent led consider progress evidenc multipl malariometr indic west africa intern center excel malaria research wa icemr multidisciplinari research program work close nmcp partner address critic research need malaria control coordin effort includ assess effect control intervent base key malaria research topic includ immun status parasit genet divers insecticid drug resist diagnost accuraci malaria vector popul bite behavior vectori capac sever signatur accomplish wa icemr includ identifi chang malaria age demograph profil test innov approach improv control strategi provid regular report drug insecticid resist status nmcp wa icemr partnership wa icemr nmcp offer comprehens research platform inform design implement malaria prevent control research program effort build local expertis capac next generat malaria research guid local polici crucial sustain effort toward elimin malaria west africa | D000852;D007306;D008288 | T047;T131;T204 |
36,228,907 | evid base malaria control elimin amazon input intern center excel malaria research network peru brazil malaria remain endem countri america case report major region malaria burden found within amazon basin includ nine countri territori south america local generat evid critic provid inform public health decis maker upon design effici region direct malaria control elimin program built plasmodium vivax predomin malaria parasit amazon basin parasit speci appear resili malaria control strategi worldwid asymptomat plasmodium infect constitut potenti infecti reservoir typic miss routin microscopi base surveil often remain untreat primari amazonian malaria vector nyssorhynchus former anophel darlingi chang behavior feed rest predomin outdoor reduc effici core vector control measur indoor residu spray distribut long last insecticid treat bed net review public health implic recent field base research carri amazonia intern center excel malaria research peru brazil discuss relat role tradit novel tool strategi better malaria control elimin across amazon includ improv diagnost method new anti relaps medicin biolog larvicid emphas need integr research public health policymak | D000852;D008288 | T047;T204 |
36,228,906 | intern center excel malaria research south asia broader malaria research india malaria evolut south asia mesa intern center excel malaria research icemr conduct research studi multipl site india record blood slide posit time also studi broader aspect diseas southwest india goa northeast assam mesa icemr invest research equip oper capac train personnel observ frequenc plasmodium falciparum plasmodium vivax infect clinic present treatment effect vector transmiss reinfect govern india partner indian us academ train research ground mesa icemr team contribut inform malaria select part india | D008288;D016778;D016780 | T047 |
36,228,905 | enhanc malaria research surveil control endem area kenya ethiopia malaria control program africa encount daunt challeng hinder progress step toward elimin diseas challeng includ widespread insecticid resist mosquito vector increas outdoor malaria transmiss lack vector surveil control tool suitabl outdoor bite vector weak malaria surveil inadequ number skill healthcar personnel ecolog epidemiolog chang induc environment modif result water resourc develop project pose addit barrier malaria control cogniz challeng intern center excel malaria research icemr work close collabor relev govern ministri agenc align research effort object strategi nation malaria control elimin program benefit local communiti overal goal assess impact water resourc develop project shift agricultur practic vector intervent plasmodium falciparum p vivax malaria kenya ethiopia date icemr advanc knowledg malaria epidemiolog transmiss immunolog pathogenesi develop tool enhanc vector surveil control improv clinic malaria surveil diagnost method strengthen capac local healthcar provid research find icemr inform health polici strateg plan ministri health quest sustain malaria control achiev elimin goal | D008288;D016780 | T047 |
36,228,904 | east africa intern center excel malaria research impact malaria polici uganda malaria lead caus diseas burden sub saharan africa east africa intern center excel malaria research also known program resist immunolog surveil model malaria prism establish provid comprehens approach malaria surveil uganda institut cohort studi robust malaria entomolog surveil network select public health facil provid platform monitor trend malaria morbid mortal track impact malaria control intervent indoor residu spray insecticid ir use long last insecticid net llin case manag artemisinin base combin therapi act well monitor antimalari drug insecticid resist prism studi inform uganda malaria treatment polici guid select llin nation distribut campaign reveal widespread pyrethroid resist led chang insecticid deliv ir continu engag interact polici maker ugandan ministri health enabl prism share evid best practic lesson learn key malaria stakehold particip malaria control program review contribut malaria polici nation guidelin present overview interact prism team member ugandan polici maker demonstr prism research influenc malaria polici control uganda | D000962;D037621;D057148;D007306;D008288;D011722 | T047;T074;T131;T121;T109 |
36,228,903 | scientif find southern central africa intern center excel malaria research ten year malaria control impact assess hypo meso holoendem transmiss zone zambia zimbabw decad southern central africa intern center excel malaria research oper local partner across studi site zambia zimbabw rang hypo holoendem vari ecolog entomolog burden malaria impact control measur assess longitudin cohort cross section survey passiv reactiv case detect observ design incorpor multidisciplinari scientif approach classic epidemiolog geospati scienc serosurveil parasit mosquito genet vector bionom find date help elabor pattern possibl caus sustain low moder transmiss southern zambia eastern zimbabw recalcitr high transmiss fatal northern zambia cryptic novel mosquito vector asymptomat parasit reservoir older children residu parasitemia gametocytemia treatment indoor residu spray time dyssynchron vector abund stockout essenti malaria commod context intract rural poverti appear explain persist malaria burden despit current intervent ongo studi high resolut transmiss chain parasit popul structur long term malaria period molecular entomolog help lay new avenu malaria control southern central africa similar set | D007306;D008288;D010271 | T047;T131;T204 |
36,228,894 | applic rapid invis frequenc tag brain comput interfac brain comput interfac bci base steadi state visual evok potenti ssvepsssvef among common use bci system requir particip covert attend visual object flicker specifi frequenc attend locat decod onlin analys power neuron respons flicker frequenc | D005074;D062207 | T074;T042 |
36,228,893 | xiehuo xiaoy decoct inhibit tfh cell expans promot tfr cell amplif amelior grave diseas xiehuo xiaoy decoct xhxi shown great potenti treatment gd mechan remain obscur increas follicular helper tfh cell reduct follicular regulatori tfr cell contribut high thyrotropin receptor antibodi trab level possibl grave diseas gd oxid stress os disrupt helper cell differenti aggrav autoimmun | D006111;D016393 | T191;T047 |
36,228,892 | efficaci curculigosid protect ischem brain injuri regul oxid stress nf b pikakt express ancient chines medicin book huangdi neij report brain sea marrow kidney main induc bone produc marrow therefor chines medicin kidney brain axi theori support evid lack studi curculigosid main compon kidney tonifi drug rhizoma curculigini use explor whether kidney tonifi drug could regul patholog state brain | D016328;D001930 | T116;T037;T129 |
36,228,891 | crataegus pinnatifida botan ethnopharmacolog phytochem pharmacolog overview crataegus pinnatifida belong rosacea famili extens distribut north china europ north america usag first describ xinxiu ben cao dri fruit crataegus pinnatifida bung crataegus pinnatifida var major n e br also known shanzha famous medicin food homolog herb long histori medicin usag china c pinnatifida function digest promot cardiovascular protect lipid reduct tradit use treat indigest cardiodynia thoracalgia hernia postpartum blood stagnat hemafecia recent year c pinnatifida attract worldwid attent import medicin econom crop due multipl excel health promot effect cardiovascular nervous digest endocrin system morbigen microorgan human bodi due medicin nutrit valu | D027825;D014315 | T109;T002 |
36,228,890 | effect materi mechan studi tibetan herbal medicin lagoti integra w w smith treat dss induc ulcer coliti base network pharmacolog molecular dock experiment valid lagoti integra w w smith l integra w w smith import origin plant famous tibetan medicin herba lagoti document treat chi ba diseas clinic symptom similar ulcer coliti uc | D003093;D004365;D010946 | T121;T047;T123;T002 |
36,228,889 | schinus terebinthifolia leaf lectin central peripher antinocicept action mediat carbohydr recognit domain delta opioid receptor prepar bark leav schinus terebinthifolia raddi common use treat toothach sore throat use medic base leav plant also report pain arthriti toothach sore throat evid indic lectin stell antinocicept agent leav | D027926;D037102 | T123;T116;T002 |
36,228,872 | newli regener dopaminerg neuron ohda lesion adult zebrafish brain prolifer olfactori bulb telencephalon migrat differenti matur diencephalon order understand biolog process under dopaminerg neuron dpn regener hydroxydopamin ohda induc adult zebrafish base parkinson diseas model studi investig specif phase neuroregener time base manner bromodeoxyuridin brdu administ h harvest brain tissu day three five seven nine postles potenti migrat prolif cell track day postles doubl puls track brdu ethynyl deoxyuridin edu cell immunohistostain astrocyt glial fibrillari acid protein gfap gene express foxa nurr nraa day three nine postles quantifi use qpcr protein express foxa day three seven postles valid use western blot techniqu doubl label edu tyrosin hydroxylas th prolif cell perform ascertain fate neuroregener process found whilst cell prolifer remain unchang area substanti dpn loss ventral diencephalon vdn transient increas cell prolifer olfactori bulb ob telencephalon tel seven day postles brdu immunoreact ir edu ir cell activ astrocyt later found signific increas vdn nearbi area tel day postles signific transient downregul foxa day three nine postles nraa day three nine postles express gene remain unchang ob tel transient downregul foxa protein express day three seven postles signific increas edu ir th ir cell vdn day postles indic matur prolif cell form day five seven postles dpn present find warrant futur investig critic factor govern distinct phase dpn regener | D009830;D059290 | T023;T025 |
36,228,871 | greater avoid saccharin cue pair passiv deliveri heroin associ select increas express crfr crfbp hippocampus rat drug abus tighten hold addict individu aspect life brought pleasur lose appeal attent motiv turn toward acquir drug rodent model self administr reward devalu previous show anim suppress intak drug pair saccharin cue show greater addict like behavior well increas gene express element corticotropin releas factor crf pathway prefront cortex mpfc hippocampus hipp ventral tegment area vta present studi explor whether observ differ compon crf signal pathway function self administr devalu cue moreov increas bodi work illustr function molecular hemispher differ reward pathway compon examin whether crf pathway compon exhibit hemispher differ respons heroin administr period trial male rat receiv brief access saccharin follow passiv ip inject heroin n salin n saccharin intak larg saccharin suppressor ls anim small suppressor ss anim statist differ trial separ ensu trial assess gene express compon crf pathway mpfc hipp vta amygdala nucleus accumben nac within hipp ls show greater express crf bind protein crfbp differ observ mpfc vta nac amygdala sever hemispher differ crf signal pathway gene detect find indic avoid experiment deliv heroin pair saccharin cue recapitul find observ avoid iv self administ heroin pair saccharin cue least term express gene within crf pathway provid evid consider given hemispher differ explor molecular phenomena | D003932;D012439 | T121;T109;T131 |
36,228,869 | nao tan qing amelior alzheim diseas like patholog regul glycolipid metabol neuroinflamm network pharmacolog analysi biolog valid alzheim diseas ad neurodegen disord character progress cognit declin current avail treatment alongsid convent tau hypothes neuroinflamm metabol disrupt also regard crucial hallmark ad studi novel chines formula nao tan qing ntq develop shown improv ad vivo experi show ntq signific mitig cognit impair burden neuroinflamm transgen ad mous model fad network pharmacolog result reveal activ compon ntq could target inflammatori metabol pathway addit hippocamp transcriptom suggest ntq regul signal pathway relat inflamm lipid metabol consist serum metabolom indic ntq could modul glycolipid metabol summari combin system pharmacolog analysi biolog valid studi demonstr ntq could allevi behavior abnorm patholog alter ad target glycolipid metabol neuroinflamm accord potenti therapeut agent ad | D000544 | T047;T048 |
36,228,868 | glutamaterg system neuropath pain emerg non opioid therapi neuropath pain diseas somatosensori nervous system afflict mani individu adequ manag current pharmacotherapi remain elus glutamaterg system neuron receptor transport intim involv pain date drug develop therapeut modul system glutam transport excitatori amino acid transport eaat remov excess glutam around pain transmit neuron decreas nocicept suggest modul glutam transport may repres novel approach treatment pain review highlight summar physiolog glutamaterg system neuropath pain preclin evid dysregul glutam transport anim pain model emerg novel therapi modul glutam transport success drug discoveri requir continu focus basic translat method fulli elucid etiolog diseas enabl develop target therapi increas efficaci astrocyt eaat may serv new way success treat suffer devast diseas | D009437 | T047;T184 |
36,228,865 | express matrix metalloproteinas associ clinic characterist solid tumor matrix metalloproteinas mmps group zinc depend enzym famili play import role regul human physiolog well patholog process especi malign tumor numer experiment studi shown mmps involv occurr develop solid tumor also play key role stage grade tumor specif process mmps involv tumor cell invas metastasi main includ degrad extracellular matrix regul gene polymorph promot epitheli mesenchym transform induct adhes molecul express correl express mmps differ solid tumor provid basi tumor marker tumor prognosi drug target review function classif nomenclatur mmps summar relev express mmps solid tumor well clinic surviv rate general prognosi associ mmps elabor provid use inform base search new target tumor therapi | D020782;D009369 | T191;T126;T116 |
36,228,864 | lack associ chromosom haplogroup attent deficit hyperact disord adhd korean boy attent deficit hyperact disord adhd major neurodevelopment disord includ multipl environment biolog caus general report preval adhd fold higher boy girl previous studi report link gene signific associ neuropsychiatr disord furthermor sever chromosom haplogroup report relat develop adhd symptom therefor analyz genet correl chromosom haplogroup adhd korean boy result show chromosom haplogroup ob xob p oac p trend borderlin statist signific subtyp analysi signific associ observ haplogroup oac adhdc odd ratio confid interv ci p howev associ could pass bonferroni correct multipl test conclus result show lack associ chromosom haplogroup occurr adhd korean boy | D001289;D065886 | T048 |
36,228,862 | molecular trace children exposur pathway environment organ pollut autism spectrum disord risk organ pollut op includ organochlorin pesticid ocp polychlorin biphenyl pcbs polybromin diphenyl ether pbdes polycycl aromat hydrocarbon pah show neuro damag effect studi concern autism spectrum disord asd risk limit case control studi asd n healthi control n children conduct differ land use set across punjab pakistan serum concentr ocp pcb congen pbdes pah measur serum pcb aor ci pcb aor ci pcb aor ci pcb aor ci signific higher pcb aor ci signific lower asd case compar control serum bde aor ci signific higher healthi control asd case among analyz ocp p p dde aor ci signific elev asd case comparison control pah serum dibenzothiophen aor ci signific higher asd perylen aor ci fluoren aor ci signific higher control addit mani serum pollut signific associ gstt gstm nullpres polymorph present genotyp variat respond xenobiot children children live proxim urban industri area greater exposur studi pollut compar rural children howev children resid rural area show higher exposur ocp comprehens studi document associ environment exposur risk sever organ pollut op contamin environment set asd risk children pakistan | D004785;D000067877;D006843;D011078;D010575;D011084 | T109;T131;T048 |
36,228,861 | effect perfluorobutan sulfon perfluorooctan sulfon lipid homeostasi mous liver perfluorobutan sulfon pfbs altern perfluorooctan sulfon pfos increas use recent year howev emerg evid rais concern potenti health risk pfbs toxicityof low dose pfbs liver explor compar pfos adult cbl mice expos gl gl pfbs gl pfos day drink water phenotyp level liver damag observ gl pfbs group cell apoptosi decreas cat activ observ gl pfbs group accumul lipid droplet increas cat activ tag level found gl pfos group lipidom analysi reveal lipid signific chang gl gl pfbs gl pfos group respect two pfbs treat group induc similar global lipid chang dose depend manner distinct pfos overal pfbs exposur induc increas phosphatidylcholin sphingomyelin decreas phosphatidylinositol pfos exposur caus increas triacylglycerol studi provid evid health hazard caus exposur low dose pfbs | D017738;D005466 | T109 |
36,228,860 | understand biolog impact organ pollut absorb nanoplast mani organ consum food contamin micro nanoparticl plastic absorb persist organ pollut pop environ act carrier vector increas bioavail live organ recent report polymethylmethacryl pmma nanoparticl low concentr toxic anim model test studi toxic diphenylamin dpa incorpor pmma nanoparticl assess use barnacl larva model organ absorpt capac dpa water commerci avail virgin pmma microparticl relat low wt h period induc exposur toxic barnacl nauplii thus pmma nanoparticl encapsul high concentr dpa dpa enc pmma prepar report precipit method achiev load dpa insid particl toxic dpa enc pmma nanoparticl test use fresh spawn acorn barnacl nauplii observ mortal nauplii dpa enc pmma exposur compar valu obtain pure dpa exposur water mortal among expos acorn barnacl nauplii exceed even high concentr dpa insid pmma nanoparticl result suggest slow releas pollut polym nanoparticl may induc signific toxic organ live dynam environ impact long term exposur dpa absorb plastic nanoparticl need investig futur | D004785;D001468;D053758;D014874 | T131;T073;T204 |
36,228,859 | compar imidacloprid clothianidin azoxystrobin runoff lettuc field use soil drench treat seed salina valley california neonicotinoid insecticid use increas last decad includ agricultur seed treatment applic chemic coat seed prior plant california multipl crop includ lettuc grown use neonicotinoid treat seed receiv direct neonicotinoid soil applic drench plant use research plot studi compar pesticid runoff four treatment imidacloprid seed treatment clothianidin seed treatment imidacloprid drench azoxystrobin seed treatment control pesticid treatment neonicotinoid azoxystrobin concentr measur surfac water runoff six irrig event grow season result show runoff concentr ng l imidacloprid drench treatment ng l clothianidin seed treatment ng l imidacloprid seed treatment ng l azoxystrobin seed treatment treatment averag percent appli mass runoff entir sampl period vari compound imidacloprid seed treatment drench similar respect clothianidin seed treatment azoxystrobin seed treatment much higher although proport imidacloprid runoff similar imidacloprid treatment mass appli soil drench x amount appli imidacloprid seed treatment surfac soil collect plant end trial neonicotinoid detect soil throughout studi averag maximum concentr ng g azoxystrobin detect two soil concentr ng g result elucid compar mass runoff result plant treat seed soil drench applic highlight valu addit work character site transport mani commod may util treat seed | D007306;D001181 | T131;T204 |
36,228,858 | occurr emerg bromin flame retard organophosph ester marin wildlif norwegian arctic understand exposur potenti sourc emerg bromin flame retard ebfr organophosph ester ope marin wildlif norwegian arctic investig concentr ebfr tissu sampl nine speci marin vertebr ope sampl three whale speci sampl collect wide rang speci contrast areal use diet includ blubber blue whale fin whale humpback whale white whale killer whale walrus ring seal adipos tissu plasma polar bear well adipos tissu glaucous gull tris ethylhexyl phosphat tehp tris chloroisopropyl phosphat tcipp rang ngg lipid weight respect blue whale fin whale ebrf ope detect limit detect low concentr addit baselin inform occurr ebfr ope marin wildlif arctic provid depth discuss regard potenti sourc detect compound inform import futur monitor manag ebfr ope | D005411;D001503;D046048;D050616 | T015;T120 |
36,228,857 | effect beach wrack fate mercuri land sea interfac preliminari studi sinc amount aquat plant alga debri call beach wrack bw increas along shore industrialis region strong abil primari produc accumul pollut potenti result deposit beach along bw despit fate impact pollut sandi beach ecosystem investig far studi examin fate neurotox mercuri labil stabl fraction bw sandi beach puck bay baltic sea addit bw beach sediment wrack associ macrofauna also analys rough estim show puck bay beach km may temporari storag kg mercuri deposit along bw annual larg proport hg bw labil potenti bioavail contribut hg fraction bw condit degre decomposit molar c n p ratio progress degrad bw decreas contribut hg adsorb surfac simultan increas proport adsorb intracellular mercuri observ bw accumul decreas oxygen content redox potenti increas methylmercuri content under sediment indic methyl hg concentr studi fauna time higher bw highest valu occur predatori sand bear spider lowest herbivor sand hopper regardless trophic posit hg occur absorb fraction indic increas relat share bw find suggest signific role bw mercuri carrier land sea interfac increas exposur beach communiti advers effect mercuri coastal ecosystem | D008628;D014874 | T131;T196 |
36,228,856 | speciat bioaccess human health risk assess chromium solid wast ultra low emiss coal fire power plant china chromium cr solid wast ultra low emiss ule coal fire power plant cfpps could engend advers effect environ human health henc solid wast sampl contain bottom ash fli ash gypsum sludg collect typic ule cfpp china studi distribut speciat bioaccess human health risk cr result show cr deplet gypsum wherea signific enrich bottom ash fli ash sludg compar feed coal ratio cr vi total cr solid wast relat low increas flow fraction cr chemic bind form impli deterior environment stabil base vitro simul digest method solubl bioavail research consortium sbrc physiolog base extract test pbet bioaccess cr gastric intestin phase reach highest valu either gypsum sludg incorpor bioaccess human health risk assess carcinogen risk cr within accept limit cr solid wast adult children conclud non carcinogen hazard quotient hq within safeti threshold mont carlo model appli evalu uncertainti analysi human health risk assess confid interv fit result consist calcul result carcinogen non carcinogen risk adult children studi expect provid insight integr bioaccess health risk assess cr solid wast ule cfpps thus conduc dispos solid wast human health protect | D060729;D062611 | T167;T131;T109;T130;T197 |
36,228,854 | plant air partit coeffici thirteen urban conif tree speci estim best gas particul matter associ pah remov polycycl aromat hydrocarbon pah import class pollut most come incomplet combust organ materi includ fossil fuel reason often found high concentr citi contamin air gas particl phase european union polici tri reduc concentr huge effort still devot mitig pollut pah one measur mitig use plant captur pah chemic due abil leav filter gas particl fraction work thirteen conif speci among frequent live temper mediterranean citi select concentr pah measur needl data spruce use back calcul air concentr pah later use obtain specif equat plant air partit coeffici k pa result show differ total pah uptak pinus pinast least picea abi effici tree close order magnitud look capabl differ speci enrich particul matter pm associ fraction pah needl pinus pinast instead least import total pah cupressus lusitanica import total pah new k pa equat use fine tune pah uptak specif amount plant biomass air concentr reduct | D000393;D064028;D011084;D028223 | T109;T131;T002 |
36,228,853 | effect nitrogen glyphos plant communiti composit simul field margin ecosystem model base ordin pin point cover data effect nitrogen glyphos plant communiti composit investig simul field margin ecosystem plant communiti composit infer pin point cover data use model base ordin method suit model pin point cover data mean structur ordin model analog standard linear model enabl us estim mean effect nitrogen glyphos interact two dimension ordin space signific effect nitrogen glyphos plant communiti composit overal speci divers effect nitrogen glyphos plant communiti composit differ signific furthermor estim combin effect nitrogen glyphos indic nitrogen glyphos enforc effect plant communiti composit synergist interact addit nitrogen glyphos found favor plant communiti domin perenni grass tendenc glyphos select plant communiti annual plant frequent result suggest use notion plant function type specif knowledg degre glyphos toler may effect predict effect glyphos communiti composit | D017753;D009584 | T082;T196;T123;T070 |
36,228,852 | long term field experi confirm necess improv biowast sort decreas coars microplast input compost amend soil microplast mp input agroecosystem particular concern sourc divers mulch film biosolid applic wastewat irrig flood atmospher input road runoff compost applic need sustain soil ecosystem servic context circular economi may sourc microplast aim studi evalu differ compost deriv urban wast impact natur quantiti coars mm microplast cmp soil use long term field experi franc compost result differ level urban wast sort investig approach includ isol microplast compost amend soil follow character use pyrolysi gcms spectrometri found coars microplast concentr vari kg per hectar depend compost type year bi annual applic valu may higher convent agricultur practic applic rate twice high normal practic compost made municip solid wast far organ amend lead highest quantiti plastic particl soil emphas urgent need limit plastic use packag improv household biowast sort result strong suggest standard regul organ matter amend applic take microplast account order prevent contamin agricultur soil moreov although impact soil bio physico chemic paramet note far howev given huge microplast input urgent need better evalu effect soil function | D000076282;D012989 | T068;T167;T131 |
36,228,851 | develop select mercuri recoveri technolog use iron iodid wast sludg non ferrous metal smelt process wast sludg non ferrous metal smelter contain high concentr mercuri hg arsenic sulfur articl minamata convent mercuri mandat recoveri hg dispos stage hg wast howev compound similar boil point hg compound consid interf substanc recoveri hg moreov high concentr requir signific energi volatil hg studi examin optim condit select recoveri hg energi reduct introduc fei addit thermal treatment thermogravimetr analysi util evalu convers hgs hgi influenc fei optim condit thermal treatment temperatur treatment time molar ratio hg fei explor simul wast indic maximum separ effici hg therebi allow select separ hg wast sludg hg content content content sequenti extract procedur appli evalu stabil hg residu result hg vapor stabil sulfid crystallin amorph form | D008628;D001151 | T121;T131;T196 |
36,228,850 | interspeci differ mammalian suscept legaci pop trace metal use skin fibroblast cell suscept trace metal legaci pop differ terrestri marin mammal studi establish first cell line indo pacif finless porpois compar cellular respons skin fibroblast cell pygmi killer whale pantrop spot dolphin indo pacif finless porpois mice human follow exposur copper methylmercuri cadmium pcb pcb bde better understand interspeci sensit mammal chemic pollut conduct risk assess compar observ effect concentr noec lowest observ effect concentr loec half maxim effect concentr ec cell viabil assay previous report pollut bodi burden mammal base vitro data indo pacif finless porpois sensit copper methylmercuri mammal pcb exposur reduc cell viabil mammal except human pcb potent gml exposur reduc cell viabil mammal contrast bde exposur reduc cell viabil terrestri mammal addit pantrop spot dolphin base vitro data natur context metal concentr methylmercuri cadmium pose higher risk cetacean human copper pose lower risk cetacean three legaci pop pcb pcb bde pose minor risk cetacean short term exposur studi demonstr speci specif vitro model may provid accur inform potenti risk pollut mammal howev due bioamplif pop potenti impact endocrin system immun system cetacean risk assess long term exposur vitro model studi | D014874;D008767;D019576;D004289;D014131;D004785 | T131;T121;T109;T123;T196;T015 |
36,228,849 | subcellular compartment aluminum reduc hazard impact rye photosynthesi aluminum al toxic limit crop growth product acid soil compar root less known toxic effect al leav al subcellular compartment also larg unknown use rye secal cereal l beira toler riodeva sensit al genotyp evalu pattern al accumul leaf cell organell photosynthet metabol chang cope al toxic toler genotyp accumul less al organell except vacuol suggest al compartment play role al toler beira genotyp psii effici stomat conduct pigment biosynthesi photosynthesi metabol less affect toler genotyp calvin cycl carboxyl compromis al exposur toler genotyp calvin cycl relat enzym phoshoglycer kinas pgk glyceraldehyd phosphat dehydrogenas gapdh trios phosphat isomeras tpi fructos bisphosphatas fbpase activ decreas sensit line h al exposur consequenti carbohydr organ acid metabol affect genotyp specif manner sugar level increas toler genotyp conclus al transport leaf compartment vacuol toler genotyp leaf cell provid complementari mechan al toler protect photosynthet apparatus therebi sustain growth | D012434;D000535 | T121;T196;T002 |
36,228,848 | fossil fuel combust relat air pollut hypertens sister studi hypertens lead risk factor diseas burden million disabl adjust life year attribut high blood pressur outdoor air pollut associ cardiovascular diseas joint effect exposur air pollut combust product hypertens rare studi conduct cross section analysi explor associ combust relat air pollut hypertens census tract level ambient concentr nine fossil fuel combust relat air toxic biphenyl naphthalen polycycl organ matter diesel emiss butadien acetaldehyd benzen acrolein formaldehyd nation air toxic assess databas monitor data link baselin residenti address women sister studi cohort hypertens enrol defin high systol mm hg diastol mm hg blood pressur take antihypertens medic use log binomi regress quantil base g comput estim individu joint effect fossil fuel combust relat air pollut hypertens compar highest lowest quartil diesel emiss preval ratio pr confid interv ci butadien pr ci acetaldehyd pr ci benzen pr ci formaldehyd pr ci pr ci individu associ higher preval hypertens pr joint effect increas ambient air toxic one quartil ci associ vari raceethn stronger associ observ among women report racesethn hispaniclatina non hispan black non hispan white conclus found air pollut fossil fuel combust may risk factor hypertens | D000393;D000397;D006973 | T069;T047;T131;T080 |
36,228,847 | chang structur assembl bacteri photosynthet communiti ecolog engin practic dianchi lake cyanobacteri bloom challeng aquat ecosystem ecolog restor effect approach cyanobacteri bloom control chang aquat communiti ecolog restor still unclear dianchi lake eutroph lake frequent cyanobacteri bloom china recent ecolog restor project caohai north part satisfactori perform studi collect water sampl site dianchi lake explor relationship water physicochem variabl aquat microbi communiti water physicochem variabl waihai south part intens chang along time wherea caohai photoautotroph communiti signific diverg caohai waihai waihai lower divers photoautotroph communiti contain higher abund cyanophycea caohai nutrient level cyanophycea exhibit strong correl wahai p photoautotroph particular caohai result unravel structur assembl bacteri photoautotroph communiti signific chang ecolog restor offer valuabl suggest photosynthet divers focus ecolog restor project | D060106;D000458 | T007;T083;T070 |
36,228,846 | isotop imprint aerosol ammonium north china plain atmospher pm pose varieti health environment risk urban environ ammonium one main compon pm role pm pollut like increas come year nh emiss still unregul rise mani citi worldwid howev partit urban nh sourc remain challeng although n natur abund n analysi promis approach purpos seldom appli across multipl citi within given region limit understand region pattern control nh sourc urban environ collect pm sampl use activ sampl techniqu winter six citi north china plain character concentr n sourc nh pm found substanti variat concentr n nh among site mean nh concentr across six citi rang g pollut day g non pollut day n rang pollut day non pollut day n decreas increas nh concentr six site found non agricultur sourc vehicl exhaust ammonia slip urban wast contribut nh pollut non pollut day respect pollut day combust relat emiss vehicl exhaust ammonia slip posit associ proport urban area popul densiti number vehicl highlight import local sourc particul pollut studi suggest analysi n aerosol nh promis approach apport atmospher nh sourc larg region approach potenti map rapid precis sourc nh emiss | D064751;D000393 | T104;T131;T197 |
36,228,845 | spatial distribut multi element moss reveal heavi metal precipit london island svalbard arctic arctic sink major pollut northern hemispher ideal place investig migrat concern metal local environ studi element includ li ti v cr mn fe co cu zn cd hg pb determin moss dicranum angustum london island ny lesund result show concentr differ element vari great differ altitud distribut low high altitud base cluster analysi signific differ among li ti v cr mn fe co cu show signific posit correl elev result may due influenc key environment factor element transport airborn dust carri wind surfac runoff snow meltwat multipl receptor model pca pmf unmix employ discuss sourc metal moss london island element show posit correl altitud attribut natur sourc zn cd hg pb lack appar correl elev interpret anthropogen sourc model among zn cd hg long rang deposit pb mix industri sourc | D019216;D044002;D008628 | T131;T196;T002 |
36,228,844 | associ endocrin disrupt chemic mixtur metabol indic among children adolesc adult popul base studi korea exposur endocrin disrupt chemic edc play role etiolog obes dyslipidemia howev studi analyz combin effect edc mixtur studi explor associ concurr exposur edc obes dyslipidemia children adolesc adult total children adolesc bmi tghdl adult korean nation environment health survey includ cross section studi urinari concentr eight phthalat metabolit three phenol three paraben one pyrethroid pesticid metabolit quantifi bodi mass index bmi measur particip triglycerid tg high densiti lipoprotein cholesterol hdl c level measur adolesc adult associ combin edc mixtur bmi tg hdl c ratio evalu use bayesian kernel machin regress bkmr age group chemic exposur except bpf bps detect particip signific moder high correl within phthalat metabolit high correl within paraben bkmr show edc mixtur associ higher bmi adolesc adult greater signific adult compar adolesc higher tghdl male adolesc adolesc mep mcpp drove main effect bmi tghdl respect adult pba bpa drove main effect bmi find studi suggest exposur edc mixtur associ higher bmi tghdl adolesc may critic period edc mixtur term outcom studi need strategi reduc edc exposur earli life stage may necessari lower risk metabol diseas | D052244;D050171 | T047;T046;T131;T039 |
36,228,843 | toxic perfluooctan sulfon pfos perfluorobutan sulfon pfbs scenedesmus obliquus photosynthet characterist oxid damag transcriptom analysi wide applic altern perfluorooctan sulfon pfos perfluorobutan sulfon pfbs frequent detect aquat environ howev aquat toxic pfbs still poor understood present work studi aquat toxic pfbs use freshwat alga scenedesmus obliquus obliquus indic toxic pfos also examin comparison result show pfbs exhibit much lower toxic obliquus pfos ec valu higher mg l day exposur pfbs contrast much lower ec valu mg l obtain pfos photosynthet effici analyz chlorophyl fluoresc also verifi pfos induc higher toxic effect alga pfbs malondialdehyd catalas superoxid dismutas result indic pfos exposur led accumul ros caus oxid damag alga therebi result inhibit growth photosynthesi alga furthermor transcriptom analysi indic signific regul key gene relat photosynthesi induc pfos fundament mechan inhibit photosynthet effici biomass growth obliquus | D044444;D000077105 | T002 |
36,228,842 | occurr profil characterist environment phenol human urin rural area northwestern china mani environment phenol bisphenol benzophenon paraben known endocrin disruptor advers affect human health howev knowledg human exposur common environment phenol chines rural area insuffici context urin sampl collect particip rural area northwest china analyz nine bisphenol three benzophenon four paraben bisphenol bpa bisphenol benzophenon bp benzophenon bp hydroxybenzophenon methylparaben mep ethylparaben propylparaben prp detect urin sampl median concentr ngml ngml ngml ngml ngml ngml ngml ngml respect signific posit correl observ bp bp well mep prp indic metabol transform combin use respect concentr mep prp femal signific higher male suggest femal expos mep prp male urinari concentr bpa bp mep prp could influenc age demograph inform annual household incom educ occup associ exposur level target phenol adult estim daili intak analyt except bpa respect tolerableaccept daili intak level studi profil demograph differ exposur environment phenol general popul rural area provid inform risk assess | D010226;D004781 | T121;T109;T037 |
36,228,835 | age associ alter macrophag respons human skelet muscl regener skelet muscl injuri age rodent character asynchron infiltr pro anti inflammatori macrophag wave lead improp incomplet regener unclear whether aberr also occur age human muscl studi quantifi macrophag respons human model muscl damag regener induc electr stimul young older adult baselin total resid macrophag cd dapi content differ young old subject pro inflammatori cd cd dapi macrophag content lower old follow damag muscl infiltr cd cd dapi macrophag lower old relat young subject increas cd cd macrophag correl chang muscl satellit cell content data show older individu compromis macrophag respons muscl regener point alter inflammatori respons potenti mechan reduc muscl regen efficaci age human | D008264;D018482 | T025;T024;T023 |
36,228,828 | recurr neural network model human event relat potenti respons intens oddbal stimul mismatch negat mmn compon human event relat potenti erp frequent interpret sensori predict error signal howev ambigu concern neurophysiolog under hypothet predict predict error signal compon whether dissoci overlap obligatori compon erp sensit physic properti sound present studi hierarch recurr neural network rnn fit erp data subject train model reproduc erp waveform evok db standard db deviant stimuli use simul respons db deviant stimuli intern state rnn effect combin generat synthet erp individu hidden unit loos analog popul level sourc model behaviour characteris use princip compon analysi stimulus condit layer individu unit respons hidden unit categoris accord tempor respons field statist signific differ among stimulus condit observ amplitud unit peak ms p ms n ms n latenc rang surpris includ measur window mmn model demonstr opposit polar chang mmn amplitud produc fall db rise db intens deviant stimuli consist loud depend sensori erp compon model studi suggest loud depend princip driver intens mmn futur studi ought clarifi distinct loud depend adapt predict error signal | D005072;D005071 | T042 |
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