PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,228,824 | effect citric acid esterif structur physicochem properti tigernut starch work esterifi tigernut starch citric acid etsc prepar first time structur vitro digest picker emulsifi capac investig format etsc confirm sem scan electron microscopi xrd x ray diffract ftir fourier transform infrar spectroscopi solid state c nmr nuclear magnet reson citric acid dosag prepar process posit correl degre substitut ds etsc increas ds solubl swell power etsc decreas crystallin degre declin proport resist starch rs increas rapid increas ds could also enhanc wettabl etsc thus improv picker emulsifi abil etsc high etsc concentr c suitabl oil phase volum ratio picker emuls benefici format stabil moreov macroscop viscos index mvi elast index ei emuls also posit relat ds etsc | D013213;D019343 | T121;T109;T123;T168 |
36,228,823 | genom wide identif character hsp gene superfamili appl snail gastropoda ampullariida express analysi temperatur stress appl snail famili ampullariida becom econom import due sever speci main genus pomacea invas heat shock protein hsps import molecular chaperon speci respond various stress prove play critic role adapt harsh environ invas appl snail recent releas genom pomacea canaliculata pomacea maculata lanist nyassanus marisa cornuarieti open opportun comprehens analysi hsp superfamili ampullariid identifi number hsp p canaliculata pcahsp greater three speci total pcahsp distribut chromosom classifi famili hsp hsp hsp hsp hsp hsp famili form monophylet clade phylogenet tree strong support valu except hsp hsp famili rna seq data show pcahsp tissu specif express level moreov identifi hsp gene stronger transcript level respons heat cold stress find inform futur studi stress adapt develop effect manag strategi focus hsps invas appl snail | D049851 | T204 |
36,228,822 | transcript factor sox requir oogenesi teleost fish nile tilapia oogenesi complex development process respons product egg oogonia fish anim howev transcript regul under oogenesi fulli understood present studi demonstr teleost fish nile tilapia sox transcript factor famili member sox involv regul oocyt growth oogenesi fluoresc situ hybrid show sox express enrich grow oocyt ovari could detect test crisprca mediat homozyg mutat sox gene disrupt oocyt growth analysi reveal sox mutat caus decreas content neutral lipid oocyt estradiol beta e product rna seq base transcriptom profil rt qpcr analysi ovari demonstr express level gene involv e product lipid accumul yolk format signific downregul follow sox mutat altogeth find indic sox requir oocyt growth nile tilapia provid insight transcript regul under oogenesi teleost fish | D023681 | T013 |
36,228,821 | remov cr vi ag graft magnet zeolitechitosan water purif synthesi adsorpt mechan paper novel graft zeolitef chitosan zmc mah tepa adsorb green synthes evalu remov cr vi ag singl bi compon solut character data xrf xrd ft ir vsm tga bet sem show success fabric adsorb abund nh nh well great recoveri properti emug effect experiment paramet includ ph valu initi concentr temperatur time coexist ion singl bi compon adsorpt investig result demonstr adsorpt capac increas enhanc shake time concentr equilibrium reach optimum ph valu cr vi adsorpt ag adsorpt maximum adsorpt capac cr vi ag ion obtain langmuir model mgg singl metal solut mgg bi compon metal solut cr vi ag respect addit adsorpt mechan cr vi ag explain term electrostat interact hydrogen bond metal ion nh nh zmc mah tepa taken togeth studi provid clean approach synthes chitosan base adsorb effici remov cr vi ag ion | D048271;D017641;D014874;D018508 | T052;T131;T121;T109;T057;T197 |
36,228,820 | gelatinpolyvinyl alcohol load magnesium hydroxid nanocomposit attenu neurotox oxid stress alzheim diseas induc rat amyloid plaqu format neuron cell death mitochondri cholinerg dysfunct key indic alzheim diseas ad studi gelatin polyvinyl alcohol pva tether magnesium hydroxid mg oh synthes nanocomposit gepvamg oh alkali co precipit character studi use ft ir xrd dls sem edx confirm success format gepvamg oh nanocomposit vitro studi clear demonstr impact gepvamg oh nanocomposit biocompat cellular uptak reduc protein express protect neuron cell death confoc studi confirm regul express subsequ vivo analysi wit protect effect gepvamg oh nanocomposit cognit synapt impair ad intraceribroventricular streptozotocin icv stz treat rat oxid stress antioxid enzym cholinerg mitochondri complex activ conduct reveal acetylcholineesteras ach malondialdehyd mda activ signific decreas contrast antioxid enzym activ found increas cortex hippocampus region brain thus present investig recommend gepvamg oh nanocomposit target ad clinic translat | D000544;D053761 | T047;T073;T048 |
36,228,819 | canavalia ensiformi lectin induc oxid stress mediat toxic genotox drosophila melanogast mannoseglucos bind lectin canavalia ensiformi seed concanavalin cona sever biolog applic mitogen antitumor activ howev mechan involv vivo toxic cona well known studi drosophila melanogast model use assess toxic genotox differ concentr nativ cona gml inhibit denatur form cona data show nativ cona affect surviv order locomotor perform fli reduc cell viabil level gml reduc nitric oxid level caus lipid peroxid increas protein non protein thiol content comet assay nativ cona e gml caus dna damag higher contrast treatment inhibit denatur cona affect oxid stress marker caus dna damag believ protein carbohydr interact cona carbohydr plasma membran probabl major event involv activ suggest nativ cona activ mechan induc oxid stress consequ dna damag | D032449;D004331 | T002;T204 |
36,228,818 | interfaci siliconnitrogen aerogel rais flame retard bamboo fiber reinforc polylact acid composit triazin deriv contain nitrogen silicon sin synthes sin hybrid aerogel cover surfac bamboo fiber bf modifi bf identifi mbf mbf ammonium polyphosph app use regul flame retard mechan properti polylact acid pla plabf composit investig use limit oxygen index loi ul vertic combust cone calorimetri thermogravimetr analysi link infrar spectra tg ir etc char residu mbf c high bf incorpor wt app generat pla display ul v rate loi valu vol plambf composit display ul v rate increas loi valu plabf composit obtain ul v rate decreas loi mbf reduc releas flammabl gase combust enhanc char abil decreas thermal conduct composit besid tensil impact strength plambf plabf due stronger interfaci adhes work provid good method regul flame retard mechan properti plabf composit | D005411;D064751 | T104;T120;T197 |
36,228,817 | function cellulos amin group cross link branch epoxi construct high perform wood adhes sustain biomass resourc favor research account biodegrad biocompat replac non renew fossil fuel develop low carbon green high valu bio base adhes inevit trend industri develop howev main factor limit applic poor water resist low bond perform herein crosslink network construct base reaction epoxi group trimethylolpropan glycidyl ether tmpeg amino group synthes amin cellulos ac form interlock bond synergi coval bond electrostat interact hydrogen bond bond strength water resist propos adhes effect improv fourier transform infrar spectroscopi ft ir x ray photoelectron spectroscopi xps solid state nuclear magnet reson spectroscopi c nmr demonstr format epoxi amin network excel bond strength water resist adhes made ac tmpeg ac tmpeg main reflect dri lap shear strength mpa wet lap shear strength mpa soak cboil water h studi reveal approach manufactur wood adhes superior bond perform except water resist | D000269;D014934 | T167;T073 |
36,228,816 | succeed high temperatur acid hydrolysi granular maiz starch introduc heat moistur pre treatment acid hydrolysi crucial method modifi granular starch often conduct low temperatur c extend period time prevent crystallin loss high temperatur acid hydrolysi htah behavior heat moistur treat hmt starch c investig first time crystallin structur starch enhanc hmt confirm rheolog thermal infrar fourier transform spectroscopi result amorph structur hmt starch preferenti hydrolyz high reactiv relat fast hydrolysi stage min crystallin flake separ starch granul accompani strengthen molecular interact hmt starch transform granul nm thick broad flake increas crystallin min hydrolysi nativ starch htah destroy crystallin structur due gelatin result main gelatin aggreg evidenc hydrolysi granular starch success perform relat high temperatur introduc heat moistur pre treatment studi could provid novel perspect combin increas temperatur pre treatment granular starch hydrolysi intensif design well strategi effici prepar small size crystallin starch promis applic picker emuls materi filler | D006358;D003313 | T168;T002;T070 |
36,228,815 | genom wide character udp glycosyltransferas gene famili reveal potenti role leaf senesc cotton uridin diphosph udp glycosyltransferas ugt involv mani metabol process essenti plant growth develop although ugt protein studi mani plant biolog function ugt gene cotton leaf senesc still unknown present studi perform genom wide survey identifi grugt gaugt ghugt gene gossypium raimondii g arboreum g hirsutum respect classifi group analysi protein motif gene structur demonstr structur function conserv occur within group diverg among differ group gene duplic analysi indic differ duplic way happen tetraploid g hirsutum two diploid speci whole genom segment duplic play main role expans ghugt famili cotton experienc purifi select long evolutionari process cotton cis act regulatori element analysi indic associ complex hormon regulatori network stress respons addit identifi ghugt candid gene respons leaf senesc analyz express pattern ghugt gene use transcriptom data two cultivar upland cotton contrast toler leaf senesc subsequ gene express profil base real time quantit pcr show select ghugt candid gene might involv aba ja regul function verif silenc ghugt gene via vig virus induc gene silenc delay dark induc leaf senesc overal result provid use valuabl inform understand evolut cotton ugt gene function leaf senesc | D003368;D016695 | T126;T116;T002 |
36,228,814 | prepar activ lignin high hydroxyl content use lewi acid demethyl reagent activ lignin demethyl improv reactiv attract extens attent howev still face mani challeng unsatisfi increas hydroxyl content undesir crack linear linkag effici demethyl signific increas hydroxyl content protect structur industri lignin explor use lewi acid modif reagent bbr use phenol hydroxyl content ar oh increas lignin structur might destroy linkag could fortun retain use alcl method could also use demethyl alkalin poplar lignin increas ar oh mmolg activ antioxid properti improv fold fold azino bis ethylbenzothiazolin sulfon acid diammonium salt abt diphenyl picrylhydrazyl dpph radic respect work would provid theori guidanc activ lignin facilit high valu applic | D008031;D058116 | T109;T123;T197 |
36,228,813 | synthesi character protocatechu acid graft carboxymethyl chitosan oxid sodium algin hydrogel schiff base reaction excess accumul free radic close relat occurr develop various neurodegen diseas studi novel protocatechu acid graft carboxymethyl chitosan oxid sodium algin pca g cmcsosa hydrogel develop maintain oxid antioxid balanc activ optim ph solubl rang ph cmcs pca graft onto cmcs skeleton via edcnh conjug aldehyd group osa form schiff base hydrogel physiolog temperatur gelat time adjust rapid within min control content osa shape hydrogel exhibit porous network structur high poros swell ratio rheolog properti benefici cell growth prolifer conjug preserv excel dpph abt radic scaveng abil adequ biodegrad within week moreov releas pca monom due degrad pca g cmcsosa hydrogel also exhibit excel biocompat protect effect h induc oxid damag pc cell result suggest pca g cmcsosa hydrogel would appear attract candid potenti biomed applic antioxid drug releas tissu engin implant materi | D048271;D020181 | T121;T047;T109 |
36,228,812 | px load silk fibroin nanoparticl revers multidrug resist inhibit hypoxia induc factor multidrug resist mdr main caus clinic chemotherapi failur new strategi overcom mdr need report multi respons silk fibroin nanoparticl sfns co load chemotherapeut drug doxorubicin dox px hypoxia induc factor inhibitor function folic acid fa combin could activ target tumor cell respond releas px inhibit hypoxia induc factor hif gene relat downstream drug resist target gene fa px dox sfns f p combin show acceler drug releas profil media simul tumor microenviron acid ph high level reactiv oxygen speci high level glutathion compar px dox sfns p without target modif cellular uptak rate f p increas addit f p quick achiev lysosom escap enabl dox rapid enter nucleus kill drug resist cell cytotox test indic ic dox mcf adr cell gml f p time lower free dox gml f p signific regul hif mdr vegf glut p gp protein overcom multidrug resist effect synergist chemotherapi strategi hif inhibit potenti use treatment multidrug resist tumor | D005349;D053758 | T073;T123;T116 |
36,228,811 | chitosan cinnamon essenti oilsodium algin tio bilay film enhanc bioactiv retent properti applic mango preserv bilay anti ultraviolet preserv film develop success incorpor cinnamon essenti oil ceo chitosan ch bioactiv layer incorpor tio sodium algin sa protect layer addit ceo improv antibacteri antioxid properti film addit tio enhanc bioactiv retent properti film remark cs film better water vapor permeabl wvp mechan properti cs film better antioxid antibacteri properti storag cs group mango maintain highest firm n highest total phenol content mg g also lowest lipoxygenas activ ukg obtain research result reveal develop chsa base bilay film incorpor ceo tio could use multifunct packag materi maintain fresh harvest mango | D048271;D009822;D031022 | T121;T109;T168;T002 |
36,228,810 | decontamin fuchsin dye carboxymethyl cellulos graft poli acryl acid co itacon acid carbon black nanocomposit hydrogel present work carboxymethyl cellulos cmc use develop hydrogel adsorb wastewat treatment applic due surfac function modifi characterist hydrogel hyd synthes graft copolym acryl acid aa itacon acid ia onto cmc backbon free radic polymer method order remedi fuchsin aqueous solut presenc cmc copolym hydrogel aa ia poli aa co ia wt enhanc equilibrium swell remov effici differ novel nanocomposit hydrogel sampl prepar vari weight percentag carbon black cb nanoparticl rang wt addit cb wt enhanc swell remov effici hyd brunauer emmett teller bet test gave surfac area g hyd hydcb respect indic incorpor cb led signific increas hyd surfac area maximum remov effici fuchsin optimum condit obtain poli aa co ia hyd hydcb respect kinet studi show pseudo second order best fit model isotherm studi show equilibrium data good fit langmuir model r poli aa co ia hyd hydcb respect langmuir model gave adsorpt capac mgg poli aa co ia hyd hydcb respect also valu n r l paramet demonstr adsorpt process physic favor adsorb studi thermodynam paramet illustr adsorpt fuchsin use adsorb spontan exotherm entropi decreas process regener studi show cmc base hydrogel higher perform ad de sorption cycl poli aa co ia addit cb hyd matrix enhanc reusabl overal hyd hydcb use promis adsorb remedi fuchsin due high swell adsorpt capabl | D002266;D014874 | T121;T109;T131 |
36,228,809 | applic xanthan gum konjac gum improv textur rheolog properti microstructur oviductus rana gel effect xanthan gum xg konjac gum kg mix gum xg kg mg gel properti oviductus rana studi use textur analysi dynam rheometri scan electron microscopi fourier transform infrar spectroscopi addit xg mg increas hard water hold capac energi storag modulus gel addit kg opposit effect mass ratio xg kg hard g springi chewi g gel maxim addit mg signific enhanc hydrogen bond hydrophob interact compar addit xg kg gel form denser stabl network structur result provid valuabl inform design prepar gel food contain xg kg | D031056 | T002 |
36,228,784 | sar cov infect dynam reveal wastewat sequenc analysi deconvolut use rna sequenc wastewat sampl valuabl way estim infect dynam circul lineag sar cov approach independ test individu therefor becom key tool monitor potenti virus howev equal import develop easili access scalabl tool highlight critic chang infect rate dynam time across differ locat given sequenc data wastewat provid analysi lineag dynam berlin new york citi use wastewat sequenc present pigx sar cov high reproduc comput analysi pipelin comprehens report end end pipelin includ step raw data shareabl report addit taxonom analysi deconvolut geospati time seri analys use simul dataset silico generat spike sampl could demonstr accuraci pipelin calcul proport variant concern voc environment well pre mix sampl spike appli pipelin dataset wastewat sampl berlin februari januari could reconstruct emerg b alpha februarymarch replac dynam b delta ba ba omicron winter use data short read generat industri scale set could see even higher accuraci deconvolut last use target sequenc dataset new york citi receptor bind domain rbd could reproduc result recov proport call cryptic lineag shown origin studi overal studi provid depth analysi reconstruct virus lineag dynam wastewat appli tool wide rang differ dataset differ type wastewat sampl locat sequenc differ method show pigx sar cov use identifi new mutat detect emerg new lineag high autom scalabl way approach support effort establish continu monitor earli warn project detect sar cov pathogen | D000086402;D000086382 | T067;T047;T005 |
36,228,774 | effect corticospin excit neuromodul elicit short durat concurr synchron associ cortic neuromuscular stimul optim paramet combin repetit associ transcrani magnet stimul rtms neuromuscular electr stimul nmes neuromodul central nervous system cns excit well understood examin corticospin excit short durat concurr synchron associ stimul appli use primari motor cortex rtms upper limb nmes intermitt theta burst stimul itb deliv burst hz repeat hz cours establish cortic facilit rtms protocol nmes appli activ extensor carpi radiali muscl durat four intervent compar itb concurr synchron hz nmes itb concurr synchron hz nmes itb concurr asynchron hz nmes itb delay synchron hz nmes singl puls motor evok potenti mep respons elicit transcrani magnet stimul primari motor cortex maximum motor respons mmax elicit radial nerv stimul compar min intervent result show corticospin excit mepmmax facilit itb concurr hz nmes intervent respons return baselin within min complet intervent result demonstr short durat concurr synchron stimul could appli effect neuromodul corticospin excit therefor repetit synchron associ stimul primari motor cortic network sensorimotor peripher circuit may enhanc use synchron hz frequenc activ concurr stimul | D009044 | T023;T029 |
36,228,744 | pharmacolog character tbp prodrug form aglycon curcumin crispr cas screen therapeut target aglycon curcumin curcumin aglycon curcumin antitumor properti varieti malign via alter multipl cancer relat biolog pathway howev clinic applic hamper due poor bioavail overcom limit develop synthes curcumin glucuronid sodium salt tbp prodrug form aglycon curcumin studi aim clarifi pharmacolog characterist tbp glucuronidas gusb profici mice curcumin glucuronid activ metabolit aglycon curcumin detect blood tbp inject wherea curcumin glucuronid detect gusb impair mice suggest gusb play pivot role convers tbp aglycon curcumin vivo tbp minim antitumor effect vitro wherea demonstr signific antitumor effect vivo genom wide cluster regular interspac short palindrom repeat crispr cas screen disclos gene associ nf b signal pathway mitochondria among highest hit vitro aglycon curcumin inhibit nf kappa b signal pathway wherea caus product reactiv oxygen speci ros ros scaveng n acetyl l cystein partial revers antitumor effect aglycon curcumin summari tbp exert antitumor effect prodrug aglycon curcumin gusb depend activ | D003474;D011355 | T121;T109;T120;T130 |
36,228,743 | novel dual ppar agonist protect liver steatosi improv insulin sensit avoid side effect insulin resist featur type diabet mellitus td strong interconnect non alcohol fatti liver diseas nafld peroxisom prolifer activ receptor gamma ppar peroxisom prolifer activ receptor alpha ppar master regul insulin sensit lipid metabol respect thiazolidinedion tzds pioglitazon target ppar high effect treat insulin resist nafld clinic util restrict side effect weight gain adipocyt hypertrophi fluid retent therefor urgent need new safer effect drug thus aim develop novel dual ppar agonist avoid known side effect preserv overal therapeut effect show novel agonist g g strong stimul glucos transport glut transloc cell membran skelet muscl cell manifest weaker lipogen effect adipocyt moreov g g improv system glucos metabol hyperinsulinemia hyperlipidemia marker liver injuri high fructos diet induc insulin resist rat mechanist studi reveal g g enhanc glut ampk skelet muscl protect liver steatosi upregul ppar improv whole bodi insulin sensit increas ppar despit increas ppar activ g g inhibit unwant side effect weight gain due adipos hypertrophi adipocyt fluid retent unlik tzds find identifi g g promis dual ppar agonist treatment nafld insulin resist improv safeti | D007333;D003924;D065626;D045162 | T121;T047;T046;T109 |
36,228,736 | emt status circul breast cancer cell impact fluidic shear stress circul tumor cell ctcs play vital role metastasi recurr breast cancer ctcs high heterogen stage epitheli mesenchym transit emt phenotyp biolog characterist differ emt stage remain poor defin conduct orthotop mous model breast cancer isol ctcs identifi two phenotyp ctcs intermedi em mesenchym ctcs mtt coloni format transwel migrat invas assay util examin cell prolifer coloni form migrat invas abil intermedi em mesenchym ctcs exhibit lower rate prolifer coloni format invas compar primari tumor cell mesenchym ctcs higher rate invas lower rate prolifer coloni format intermedi em ctcs also exhibit lower rate growth metastasi primari tumor cell vivo mesenchym ctcs higher rate metastasi intermedi em ctcs fluid shear stress induc emt transit ctcs comprehens analysi ctcs proteom discov protein differenti express two type ctcs primari tumor cell | D009360 | T191;T025 |
36,228,733 | genom insight metabol potenti novel lignin degrad polyhydroxyalkano produc bacterium pseudomona sp hua lignin abund heterogen aromat polym present planet earth recalcitr degrad due complex structur therefor impos challeng biorefineri procedur identifi new microbi strain potenti valor lignin use compound indispens achiev green sustain consumpt studi novel pseudomona strain design hua isol termit gut genom sequenc analyz genom contain circular chromosom size bp gc content gene genom annot reveal strain possess lignin oxid enzym dyp type peroxidas laccas dioxygenas aromat degrad gene cluster genom also contain methyltransferas function acceler lignin degrad methyl free hydroxyl phenol compound high concentr inhibit lignin peroxidas furthermor genom exhibit two gene cluster encod enzym relat polyhydroxyalkano pha synthesi pseudomona strain general assum produc medium chain length phas mcl phas howev strain hua contain class ii pha synthas gene involv mcl phas class iii pha synthas gene involv short chain length phas scl phas gas chromatographi mass spectrometri gc ms analysi show use gl lignin sole carbon sourc maximum product pha observ mgl increas mgl increas lignin concentr gl howev pha product use glucos sole carbon sourc signific lower lignin sourc maximum product mgl gl glucos strain hua toler broad rang solvent includ methanol isopropanol dimethylformamid ethanol reveal potenti industri applic | D054813 | T109 |
36,228,732 | assess magnet properti biomonitor road dust screen method air pollut monitor particul matter pm pollut one world serious environment challeng among pm compon atmospher heavi metal hms consid one main pollut respons caus signific negat impact human health ecolog qualiti studi aim assess environment magnet simpl rapid method use evalu heavi metal contamin urban area relationship magnet properti heavi metal concentr purpos road dust leaf sampl two common evergreen speci cupressus lusitanicacasuarina equisetifolia sampl simultan year site differ level traffic pollut result found signific statist correl magnet properti chemic substanc plant studi fe cr v show r cr zn r lf c equisetifolia frequenc depend magnet suscept found plant road dust suggest rather dissimilar particl size distribut plant less import contribut hazard ultrafin superparamagnet magnetit confirm magnet analys use distinguish differ degre urban air pollut | D000397;D019216 | T069;T196;T080 |
36,228,730 | bioplast known effect potenti consequ marin estuarin ecosystem servic bioplast suggest sustain altern convent petroleum base plastic work avail studi compar effect biopolym petroleum base plastic review improv knowledg sustain biobas polym provid benchmark regard ecotoxicolog effect well highlight research prioriti field literatur review show small number avail biopolym test highlight need research diversifi test polym overal avail studi support idea bioplast like caus physiolog impair feed reproduct locomot well cellular proteom enzym activ effect biota furthermor studi bioplast degrad realist condit report chang water sediment qualiti may also consequ biota evid reserv must kept regard convent plastic substitut bioplast | D017753;D010578 | T082;T109;T070 |
36,228,729 | biogen synthesi reduc graphen oxid decor silver nanoparticl rgoag nps use tabl oliv olea europaea effici rapid catalyt reduct organ pollut work graphen oxid go sheet prepar via facil electrochem exfoli graphit acid medium subsequ oxid potassium permangan go sheet employ prepar reduc go adorn nanos silver rgoag nps use green reduct go ag via oliv fruit extract reduc immobil agent crystal phase morpholog nanostructur prepar catalyst character xrd sem edx uv vis raman spectroscopi techniqu prepar rgoag nps show superior catalyt perform toward complet reduct nitrophenol nph aminophenol aph rhodamin b rhb leuco rhb within use nabh ambient condit rate constant k valu found nph rhb reduct respect addit regener catalyst could reus seven cycl without lose appar catalyt effici account excel catalyt capabl chemic stabil environ friend synthesi protocol rgoag nps great potenti work heterogen catalyst transform harm organ contamin less harm harmless compound | D006108;D031658;D053768;D004785 | T073;T002;T131;T109;T196;T168 |
36,228,728 | insight heterogen activ h goethit visibl light cefradin degrad ph depend photoassist effect iron miner catalyz degrad cephalosporin antibiot h occur ubiquit natur despit numer studi effect environment condit reactiv speci product degrad process cephalosporin remain unclear report iron miner goethit effici heterogen catalyst degrad cefradin crd via h activ differ condit involv ph visibl light irradi result show crd remov rate high depend ph visibl light irradi interest ph rang degrad intermedi crd dark visibl light condit goethiteh system ratio crd degrad rate constant k light k dark reach maximum ph suggest crd exist zwitterion speci prefer remov photoassist mechan investig reveal oh fe iv oxid generat reaction process oh major oxid acid ph fe iv like form photoassist near neutral ph accord uplc msms analysi crd degrad like happen via hydrogen atom abstract cyclohexadienyl oh thioether olefin oxid fe iv fe iii catalyz hydrolyt cleavag lactam ring find highlight vital role ph photoassist heterogen activ h goethit crd degrad | D006861;D002515 | T195;T121;T109;T130;T197 |
36,228,726 | ecolog risk assess metal arctic environ emphasi kongsfjorden fjord freshwat lake ny lesund svalbard concentr five heavi metal cd cr cu pb zn sediment water phytoplankton zooplankton macroalga kongsfjorden fjord freshwat lake ny lesund svalbard archipelago determin order describ anthropogen impact relat ny lesund town water sampl nine station sediment sampl station plankton sampl five station six speci macroalga collect subject heavi metal analysi use atom absorpt spectrophotometri aa cu zn detect water sampl plankton sampl zn cu cr averag metal concentr macroalga fell decreas order cu zn cr cd pb sediment sampl metal order follow zn cu cr pb cd multivari statist analys includ princip compon analysi pca hierarch cluster analysi hca use identifi sourc metal contamin metal found origin blend anthropogen geogen sourc pollut monitor indic includ geoaccumul index geo contamin factor contamin degre c deg pollut load index pli potenti ecolog risk per calcul use metal data studi area geo valu metal show pollut grade uncontamin extrem contamin c deg fell class low contamin high contamin pli valu rang per valu express except station locat higher elev glacial outwash plain site high pollut high level pollut indic site attribut anthropogen activ persist studi area | D019216;D014874 | T131;T196 |
36,228,725 | ecotox character chemic global recommend implement usetox chemic emit environ affect ecosystem health local global scale reduc chemic impact becom import element european global sustain effort present work advanc ecotox character chemic life cycl impact assess propos recommend result intern expert workshop work conduct umbrella unep setac life cycl initi glam project global guidanc environment life cycl impact assess indic includ specif recommend broaden assess scope propos introduc addit environment compart beyond freshwat relat ecotox indic well adapt ecotox effect model approach better reflect environment relev exposur level includ larger extent chronic test data result propos consist mathemat framework calcul freshwat ecotox character factor under fate exposur effect paramet implement framework usetox scientif consensus model calcul character factor chemic report inventori life cycl assess case studi rice product consumpt investig influenc effect data select criteria result indic score result highlight need care interpret life cycl assess impact score light robust under speci sensit distribut next step appli recommend character framework addit case studi adapt soil sediment marin environ framework applic evalu chemic life cycl assess chemic environment footprint chemic substitut risk screen chemic priorit comparison environment sustain target | D017753;D005618 | T082;T167;T070 |
36,228,724 | novel method base solid phase extract liquid chromatographi tandem mass spectrometri warrant occurr trace xanthat water huge volum wastewat contain organ flotat reagent xanthat releas environ via mine activ great threaten eco environ safeti simpl fast method urgent need accur analysi various xanthat mine environment water robust method realiz simultan determin three trace xanthat ie potassium ethyl xanthat potassium butyl xanthat potassium isopropyl xanthat environment water sampl includ eutroph water flotat wastewat use solid phase extract spe hplc msms hplc msms paramet spe cartridg elut solvent ph valu spe procedur optim new method excel linear rang gl r low limit detect gl satisfactori accuraci precis averag recoveri relat standard deviat gl xanthat first method develop determin trace xanthat water sampl success appli determin target analyt outdat flotat wastewat river water sampl warrant occurr trace xanthat gl water necess systemat investig environment fate risk xanthat | D014874;D007306 | T131 |
36,228,722 | biotransform bisphenol bis diphenyl phosphat vitro silico non target analysi metabolit rat bird liver microsom model increas product usag organophosph ester ope flame retard plastic trend toward larger novel oligomer ope although dearth understand environment fate stabil toxicokinet biotransform bioaccumul novel ope expos biota present studi character vitro biotransform novel ope bisphenol bis diphenyl phosphat bpadp use wistar han rat herring gull liver base microsom assay hypothes target metabolit bisphenol bpa diphenyl phosphat dphp metabolit investig appli line evid approach silico model predict bpa dphp rat metabolit bpadp metabolit quantifi via uhplc qqq msms addit non target metabolit determin uhplc q exact orbitrap hrmsms identifi compound discover softwar mean bpadp deplet quantifi convers bpa dphp respect rat assay bpadp metabol much slower compar well studi ope triphenyl phosphat tphp bpadp deplet gull liver assay far slower relat rat addit non target metabolit identifi includ two phase dealkyl product five phase oxid product one phase ii glutathion adduct demonstr agreement line vitro silico evid line evid suggest bpadp biolog persist expos mammal bird find add understand bpadp stabil biotransform perhap novel ope factor high applic hazard assess exposur persist bioaccumul biota | D010710;D005411 | T120;T197 |
36,228,721 | insight degrad microplast fenton oxid surfac modif miner work aim evalu fate microplast mps along fenton oxid goal realist mps five repres polym type pet pe pvc pp ep obtain commerci plastic product cryogen mill experi h perform relat sever oper condit c ph h mgl dose everi h fe mgl dose everi h slight mps weight loss achiev fenton oxid regardless mp natur nevertheless oxid yield clear increas decreas particl size given higher expos surfac area weight loss ep mps clear mps suffer import chang surfac due introduct oxygen group made acid hydrophil furthermor mps progress reduc size fact complet oxid co demonstr oxid ps nanoplast nm miner achiev natur plastic particl relev impact overal oxid prone oxid polym contain aromat ring structur ep pet compar form alkan chain pe pp pvc latter presenc substitu also reduc oxid potenti remark possibl leachat releas along reaction quick oxid mpsnps assum dissolv compound would complet remov solid particl elimin notabl leachat obtain upon mps oxid biodegrad releas fresh solid knowledg crucial understand mps oxid fenton process open door design optim technolog either water treatment analyt purpos mps isol | D000080545;D010969 | T167;T122 |
36,228,720 | vivo degrad polyethylen terephthal use microbi isol plastic pollut environ accumul plastic alarm risk environ worldwid polyethylen pterephthal pet degrad slowli produc hazard substanc therefor essenti elimin plastic wast environ given current studi concern pet degrad potenti natur occur microbi strain isol plastic wast dump site sarcina aurantiaca tb bacillus subtili tb aspergillus flavus stf aspergillus niger stf test biodegrad pet film film incub day c microorgan design tb tb stf stf microbi consortium tbtbstfstf minim salt medium bushnel hass broth hydrophob viabil total protein content isol investig use field emiss scan electron microscopi fourier transform infrar spectrophotometri measur variat function group carbonyl index pet surfac biodegrad process affirm fissur modifi surfac result reveal microbi consortium aurantiaca b subtili flavus niger weight loss pet film microbi consortium could use treat pet wast pose health environment risk develop microbi consortium potenti degrad pet henc employ elimin pet plastic contamin site | D010969;D011093 | T167;T109;T122 |
36,228,717 | causal role right dorsolater prefront cortex norm guid social decis make meta analysi tms studi theoret account ascrib right dorsolater prefront cortex rdlpfc crucial role social decis make previous studi assess rdlpfc function transcrani magnet stimul tms provid inconsist evid studi suggest rdlpfc promot norm guid behavior other report rdlpfc implement selfish choic decid conflict account conduct meta analysi studi investig impact rdlpfc tms social decis make observ signific effect rdlpfc tms across studi moder analys reveal rdlpfc role social decis make crucial depend social context particular found rdlpfc promot norm guid behavior predomin decis maker trade interact partner intent fair expect selfish interest reactiv fair contrast evid rdlpfc tms affect prosoci give proactiv fair result thus inform theoret account show brain stimul rdlpfc increas decreas norm guid behavior per se instead contextu factor determin role rdlpfc social interact | D050781;D017397 | T023;T030;T061;T029;T062 |
36,228,716 | cancer therapi immun checkpoint inhibitor csf blockad mathemat model immun checkpoint inhibitor ici introduc recent year revolution treatment mani metastat cancer howev data suggest treatment benefit limit percentag patient due immun suppress tumor microenviron tme anti tumor inflammatori macrophag attract tme convert tumor secret cytokin csf pro tumor anti inflammatori macrophag tumor associ macrophag tam block anti tumor cell present paper develop mathemat model repres interact among immun cell cancer term differenti equat model use assess treatment combin therapi anti pd anti csf exampl given compar efficaci among differ strategi anti csf dose setup clinic trial | D000082082;D009369 | T121;T191;T043;T129 |
36,228,715 | develop enzym link immunosorb assay quantif phosphoethanolamin human plasma phosphoethanolamin pea endogen substanc attract interest biomark depress thus need develop simpl analyt method specif measur pea therefor studi aim develop simpl specif enzym link immunosorb assay elisa pea anti pea antibodi obtain immun mice antigen conjug mercaptosuccinyl bovin serum albumin use maleimidobenzoyl n hydroxysulfosuccinimid ester mbs assay pea quantifi chemic modifi benzoyl chlorid allow compet pea mbs hrp conjug bind limit amount anti pea antibodi use coat well microtit plate elisa show linear rang detect limit quantif anti pea antibodi show high affin benzoyl pea detect cross reactiv found benzoyl aminoethanol phospho l tyrosin benzoyl sphingosin phosphat valu plasma pea level measur elisa compar measur hplc strong correl observ valu determin two method develop elisa provid valuabl new tool quantif pea human plasma | D004983;D000941 | T109;T129 |
36,228,705 | cannabidiol acid activ express ppar target gene mda mb cell cannabidiol acid cbda activ peroxisom prolifer activ receptor ppar ppar whether cbda activ ppar examin suffici date sinc previous studi show tripl negat breast cancer cell respond activ ppar present studi examin effect cbda mda mb cell compar activ cbda known ppar agonistsantagonist express ppar target gene angiopoietin like angptl adipocyt differenti relat protein adrp increas cbda interest ligand activ ppar gw caus increas express angptl adrp magnitud effect mark increas co treat cbda specif effect confirm show cbda induc express angptl adrp mitig presenc either ppar antagonist invers agonist result studi suggest cbda synerg ppar might interact endogen agonist modul ppar function | D048068;D047494;D002186 | T121;T109;T116;T192 |
36,228,703 | prolong liver fluke infect combin alcohol experiment mous model liver fluke infect disrupt bile excret function human liver worldwid excess alcohol consumpt also lead primarili liver diseas aim comprehens assess liver state mice parallel character inflamm two advers factor combin cbl mice use experiment model half beforehand gradual accustom consumpt increas dose ethanol half anim subgroup infect opisthorchi felineus helminth final infect ethanol consum eth subject factor eth mice compar treatment control especi eth mice relat liver weight greater activ alanin aminotransferas aspart aminotransferas higher bile duct consider enlarg eth mice contain notic helminth liver mice massiv cholangiofibrosi periduct fibrosi note liver infect mice especi eth one liver fluke infect caus inflammatori infiltr bile duct prolifer splenomegali due structur chang spleen well increas level interleukin leukocyt monocyt count blood reflect substanti inflamm eth mice thus propos experiment model shown doubl hit liver ie combin felineus infect prolong alcohol detriment liver whole bodi | D009889;D009891;D000428 | T055;T047;T204 |
36,228,701 | role pfmyst dna replic plasmodium falciparum chromatin modif histon acetylationdeacetyl import regul transcript well dna replic eukaryot pfgcn pfmyst two well studi histon acetyltransferas plasmodium pfmyst contain myst domain zinc finger domain chromodomain primarili acetyl histon show pfmyst express two isoform long version kda short version kda protein shorter version predomin present nucleus associ pfmyst putat plasmodium autonom replic sequenc pfar found much stronger bind pfgcn region concomit enrich h acetyl level bind pfmyst site also correl anoth replic protein pforc well replic stage trophozoit parasit collect result show first time potenti role pfmyst parasit dna replic chromatin modif may found use intervent parasit growth | D010963;D015800 | T123;T116;T204 |
36,228,647 | respons subgroup patient schizophrenia differ antipsychot drug systemat review meta analysi compar trial subgroup patient schizophrenia done clinician need know whether reli result randomis control trial rcts general popul patient schizophrenia aim compar efficaci side effect antipsychot drug differ subgroup | D014150;D011618;D012559;D019966 | T121;T048;T039;T033 |
36,228,644 | singl dose carboplatin follow involv node radiotherapi stage iia stage iib seminoma sakk singl arm multicentr phase trial standard treatment option patient stage iia stage iib seminoma includ either para aortic pelvic radiotherapi three four cycl cisplatin base combin chemotherapi option result year progress free surviv rate least bear risk acut late toxic effect includ secondari malign test novel approach combin de escal chemotherapi de escal involv node radiotherapi aim reduc toxic preserv efficaci | D018239;D013736 | T191 |
36,228,643 | ucart first class allogen anti cd chimer antigen receptor cell therapi adult relaps refractori b cell acut lymphoblast leukaemia calm phase dose escal trial prognosi adult relaps refractori b cell acut lymphoblast leukaemia remain poor ucart allogen genom edit anti cd chimer antigen receptor car cell product deriv healthi donor avail immedi clinic use offer potenti therapeut option patient calm trial first human studi evalu safeti antileukaem activ ucart adult patient relaps refractori b cell acut lymphoblast leukaemia | D000076962;D054198;D018380;D008224 | T116;T192;T061;T191;T129 |
36,228,640 | daili use later flow devic contact confirm covid case enabl exempt isol compar standard self isol reduc onward transmiss sar cov england randomis control non inferior trial uk studi period april juli contact peopl covid requir self isol day advers impact individu societi avoid need self isol remain uninfect would benefici investig whether daili use later flow devic lfds test sar cov remov self isol h negat could safe altern self isol mean minimis onward transmiss virus | D000086402;D000086382 | T067;T047;T005 |
36,228,635 | bioprosthet total artifici heart implant induc chronic inflamm aeson total artifici heart tah develop patient risk death biventricular failur aim assess inflammatori status nine subject implant tah kinet one year laboratori assess leukocyt count inflammatori cytokin assay peripher blood mononuclear cell collect tah implant leukocyt count signific modul accord time tah implant coeffici linear mix effect model ci p explor inflammatori cytokin tah observ time modifi profil compar pre implant valu p valu final compar distribut circul immun cell subpopul identifi base sequenti express pattern multipl cluster differenti none popul explor signific modul month follow p valu conclus use cytokin multiplex assay combin flow cytometri approach demonstr absenc inflammatori signal peripher blood period month follow tah implant | D016027;D006354;D006333 | T046;T061;T047;T074 |
36,228,623 | unsupervis convolut neural network method estim intravoxel incoher motion paramet objectiveintravoxel incoher motion ivim imag obtain fit biexponenti model multipleb valu diffus weight magnet reson imag dw mri shown promis tool differ clinic applic recent sever deep neural network dnn method propos generat ivim imagingapproachin studi propos unsupervis convolut neural network cnn method estim ivim paramet use simul real abdomin dw mri data evalu perform propos cnn base method compar result obtain non linear least squar fit trr trust region reflect algorithm feed forward backward propag dnn base methodmain resultsth simul result show dnn cnn base method lower coeffici variat trr method cnn base method provid accur paramet estim result obtain real dw mri data show trr method produc mani bias ivim paramet estim hit upper lower paramet bound contrast dnn cnn base method yield less bias ivim paramet estim overal perfus fraction diffus coeffici obtain dnn cnn base method close literatur valu howev compar cnn base method trr dnn base method tend yield increas pseudodiffus coeffici significanceour preliminari result suggest feasibl estim ivim paramet use cnn | D038524;D000465 | T060;T170 |
36,228,622 | estim method anisotrop electr conduct ofin vivohuman muscl fat khz mhz objectivein low frequenc dosimetri variabl electr conduct valu assign bodi model tissu repres major sourc uncertainti aim studi propos method estim conduct human anisotrop skelet muscl fatin vivoin frequenc rang khz mhzapproacha method base bound electr imped tomographi use bioimped measur perform leg ten subject anatom realist model leg creat use magnet reson imag invers problem tissu conduct solv use finit element method result valid use resampl techniqu find also use studi effect muscl anisotropi magnet field exposuremain resultsth estim conduct anisotrop muscl found good agreement valu found exist literatur anisotropi shown decreas increas frequenc ratio later longitudin conduct increas conduct fat found almost constant frequenc rang consideredsignificanceth propos method shown viabl option estimatingin vivoconduct human tissu result use numer dosimetri calcul limit futur investig studi conduct bioimped measur | D008279;D018482 | T023;T059;T060;T170;T024 |
36,228,621 | correl gut microbiota metabol function antibodi respons bbibp corv vaccin increas evid indic gut microbiota may play key role vaccin immun investig whether human gut microbiota metabol function correl bbibp corv vaccin respons total particip receiv bbibp corv vaccin enrol gut microbiom metabol function investig use metagenom sequenc metabolom assay find bbibp corv vaccin accompani alter microbiom composit function pathway gut microbiom function profil correl vaccin respons level short chain fatti acid scfas much higher high antibodi respons group compar low respons group sever scfas display posit correl antibodi respons studi highlight gut microbiom function associ bbibp corv vaccin respons provid evid explor microbiom modul improv covid vaccin efficaci | D000069196;D000086382 | T007;T001;T047;T067 |
36,228,617 | loss non motor kinesin kifa caus congenit brain malform via dysregul neuron migrat axon growth well apoptosi kinesin canon molecular motor also function modul intracellular signal kifa unconvent kinesin lack motor activ inhibit growth factor receptor bound protein grb focal adhes kinas fak depend signal transduct function brain character report patient cohort biallel loss function variant kifa exhibit spectrum congenit brain malform develop brain kifa preferenti express earli mid gestat excitatori neuron combin mice human ipsc deriv organoid model discov loss kifa caus excitatori neuron specif defect radial migrat local dendrit axon growth apoptosi offer convinc explan diseas etiolog patient singl cell rna sequenc kifa knockout organoid reveal transcript chang mapk myc ef pathway find illustr pathogenesi kifa loss function variant identifi surpris versatil non motor kinesin | D016547;D009474 | T126;T025;T123;T116 |
36,228,616 | obes caus ovol mutat reveal dual role ovol promot thermogenesi limit white adipogenesi use random germlin mutagenesi mice identifi viabl hypomorph allel boh transcript factor encod gene ovol result obes initi develop normal food intak physic activ decreas energi expenditur fat weight dramat increas lean weight reduc week old boh homozyg mice culmin week massiv obes hepatosteatosi insulin resist diabet ovol bohboh genotyp augment obes lep obob mice pair feed fail normal obes ovol bohboh mice ovol defici mice extrem cold intoler ovol essenti brownbeig adipos tissu mediat thermogenesi white adipos tissu ovol limit adipogenesi block cebp engag transcript target overexpress ovol adipocyt mice fed high fat diet reduc total bodi liver fat improv insulin sensit data reveal ovol play dual function thermogenesi adipogenesi maintain energi balanc | D050156;D007333 | T046;T044 |
36,228,615 | differenti plastic fate brain resid recruit macrophag onset resolut neuroinflamm microglia border associ macrophag bam brain resid self renew cell examin fate microglia bam recruit macrophag upon neuroinflamm resolut upon infect trypanosoma brucei parasit invad brain via border region trigger brain barrier disrupt monocyt infiltr fate map combin singl cell sequenc reveal microglia accumul around ventricl expans epiplexus cell deplet experi use genet target reveal resid macrophag promot initi parasit defens subsequ facilit monocyt infiltr across brain barrier recruit monocyt deriv macrophag outnumb resid macrophag exhibit transcript plastic adopt antimicrobi gene express profil recruit macrophag rapid remov upon diseas resolut leav engraft monocyt deriv cell parenchyma resid macrophag progress revert toward homeostat state long term transcript alter limit microglia pronounc bam thus brain resid recruit macrophag exhibit diverg respons dynam infect resolut | D000090862;D008264 | T047;T025;T033 |
36,228,613 | cns remyelin inflamm basic mechan therapeut opportun remyelin myelin regen respons follow demyelin restor saltatori conduct function sustain axon health declin effici diseas progress chronic autoimmun diseas multipl sclerosi ms contribut current untreat progress phase diseas although bona fide myelin regen medicin clinic trial succeed demonstr proof principl none compound yet proceed toward approv therefor remain need increas understand fundament biolog remyelin exist target refin new one discov review role inflamm particular innat immun remyelin describ mani complex facet discuss evolv understand har translat goal | D000074586;D009103 | T043;T047 |
36,228,611 | applic simpl dna damag model develop electron proton irradi proton beam therapi allow irradi tumor volum reduc side effect normal tissu respect convent x ray radiotherapi biolog effect cell kill proton beam irradi depend proton kinet energi intrins relat earli dna damag induct dna damag estim base mont carlo simul research topic worldwid interest simul mean investig mechan dna strand break format howev past model consid chemic process dna structur requir long calcul time particl heavi ion transport system phit one general purpos mont carlo code simul track structur proton meanwhil handl radic dynam simul liquid water also includ simpl model enabl effici estim dna damag yield spatial distribut ionize excit without dna geometri origin develop electron track structur simul studi investig potenti applic model proton without modif yield singl strand break doubl strand break dsbs complex dsbs assess function proton kinet energi phit base estim show dsb yield increas linear energi transfer let increas reproduc experiment simul yield various dna damag type induc proton let kevm result suggest current dna damag model implement phit suffici estim dna lesion yield induc proton irradi except low energi mev model contribut evalu earli biolog impact radiat therapi | D004583;D011522 | T196;T081 |
36,228,610 | tread tread comparison water tread convent flap wing kinemat hover insect limit physiolog need rotat wing end back forth motion keep wing lead edg ahead trail edg wing rotat end half stroke push lead edg vortex away wing lead loss lift unlik biolog flier human engin flap wing micro air vehicl differ design limit design avoid end stroke wing rotat use call water tread flap kinemat flap wing use convent flap kinemat design lead trail edg water tread mode role lead trail edg continu altern throughout stroke compar veloc field forc measur rectangular flap wing conduct normal hover water tread kinemat studi differ fluid dynam perform two type flap kinemat show similar power consumpt water tread mode produc lift convent hover mode effici symmetr pitch kinemat water tread mode lead edg vortex previous stroke push away captur keep newli form lead edg vortex closer wing lead rapid increas lift coeffici sustain longer make water tread mode promis altern human engin flap wing vehicl | D005426;D020521 | T047;T040 |
36,228,609 | covid pregnanc risk unborn child geburtskliniken werden zunehmend mit covid erkrankten schwangeren konfrontiert die stellt geburtshelf vor groe herausforderungen da einig fragestellungen noch nicht ausreichend wissenschaftlich erforscht sind ber covid whrend der schwangerschaft und sein auswirkungen auf das ungeboren und neugeboren kind ist nicht viel bekannt | D000086382 | T047;T067 |
36,228,607 | hill type bioinspir actuat deliv energi economi dc motor electromagnet motor convert store energi mechan work linear forc veloc fv relationship biolog system howev muscl actuat character hyperbol fv mechan hill muscl paramet character degre nonlinear previous work shown bioinspir human engin system contribut favor mechan attribut energi effici self stabil flexibl among other studi first construct easili amend bioinspir electromagnet motor produc fv curv mimic hill model muscl high degre accuraci proport integr differenti pid control converg characterist linear fv relationship dc motor nonlinear hill type forc output bioinspir electr motor fix amount work lift g mass record translat veloc mass nonlinear appli forc motor optim gain coeffici pid bioinspir motor achiev agreement ofr hill muscl model studi shown design biolog inspir actuat produc compar energi effici system investig energi economi actuat motor nonlinear hill type forc direct comparison convent linear fv actuat techniqu find bioinspir motor deliv energi economi respect energi consumpt convers nonlinear hill type dc motor reduc energet cost actuat deliv fix amount mechan work | D017711;D009132 | T024;T170;T077 |
36,228,600 | hospit crisi manag pandem pandem pose differ challeng hospit classic damag event crise requir specif manag structur oper strateg level hospit therefor need crisi manag structur process allow hospit react crise affect hous case pandem crisi team use manag tool emerg servic public agenc privat compani alik also establish hospit oper strateg level sinc crisi team hospit part everyday work regular train exercis indispens furthermor financ includ train staf must provid | D000086382;D058873 | T047;T067 |
36,228,599 | clinic treatment terrorist attack structur process hospit terror relat mass casualti incid due sever peculiar clinic treatment terror relat mass casualti incid terrormasc differ handl convent mci reason terrormasc situat get attent entiti hospit emerg prepared respons among challeng hospit surround emerg area deal larg amount non triag non treat serious harm patient unfamiliar disfigur injuri addit hospit endang target terrorist attack therefor secur concept depend individu circumst must elabor consult local polic authoritiesth incid clinic manag put hand special train hous institut oper tactic task close patient site separ strateg administr respons background function emerg oper medic coordin eomc zonk instal manag initi diagnost therapi serious injur victim priorit schedul avail clinic resourcesin order structur process emerg admiss numer patient triag hold area well specif hous treatment area differ sever injuri set clinic triag follow consist algorithm base cabcd approach recommend algorithm defin hospit disast emerg planningsurg strategi concern treatment terror victim might orient accord principl tactic abbrevi surgic care tasc mean extrem case initi measur concert save much live possibl accept reduc individu outcom | D004189;D054527;D023481 | T064;T051;T052;T098;T054 |
36,228,598 | manag clinic capac overload due mass patient influx hospit play crucial role manag larg scale emerg disast clear demonstr recent terrorist attack europ sar cov pandem current ukrain war order cope extraordinari situat larg scale emerg mass casualti incid hospit need prepar detail prepar implement hospit conting plan articl present describ hospit prepar mass casualti incid | D000086382;D004189;D054527;D023481 | T047;T064;T051;T052;T098;T054;T067 |
36,228,595 | develop miniatur reconnect implant multichannel connector object connector implant neural prosthet system provid sever advantag simplif surgeri safe replac implant devic modular design implant system rapid advanc technolog neural implant miniatur multichannel implant connector also requir studi propos reconnect area effici multichannel implant connector approach femal femal adapt fabric use thermal press bond micropattern liquid crystal polym film bump insid adapt enabl reliabl electr connect increas contact pressur contact pad adapt insert cabl connect adapt enclos metal case seal silicon elastom pack differ size pack leakag current test perform acceler condit determin optim design long term reliabl repeat connect test perform verifi durabl reconnect fabric connector connector implant rat leakag current monitor evalu stabil connector vivo main result fabric four eight channel implant connector assembl metal case diamet length mm respect contact resist four eight channel connector respect electr contact remain stabl repeat connect test time fabric connector pack volum ratio intern space metal case fail respect c salin environ anim test rat connector maintain low leakag current level signific implant reconnect multichannel connector develop evalu feasibl propos connector evalu term electr mechan characterist well seal perform propos connector expect potenti applic implant neural prosthet system | D019736 | T074 |
36,228,593 | spinal stimul motor rehabilit immedi modul nocicept transmiss object spinal cord injuri sci often result debilit movement impair neuropath pain electr stimul spinal neuron hold consider promis enhanc neural transmiss weaken motor pathway reduc neural transmiss overact nocicept pathway howev spinal stimul paradigm current develop individu live sci continu overwhelm develop context motor rehabilit alon object studi test hypothesi motor target spinal stimul simultan modul spinal nocicept transmiss approach character neuromodulatori action motor target intraspin microstimul ism fire dynam larg popul discret nocicept specif wide dynam rang wdr neuron neuron access via dens microelectrod array implant vivo lumbar enlarg rat nocicept non nocicept cutan transmiss induc ism mechan probe l dermatom main result primari find sub motor threshold ism deliv spinal motor pool immedi modul concurr nocicept transmiss b magnitud anti nocicept effect increas longer durat ism includ robust carryov effect c major identifi nocicept specif wdr neuron exhibit fire rate reduct min ism ism increas spinal respons non nocicept cutan transmiss result lead conclus ism parameter enhanc motor output result overal net decreas n spinal nocicept transmiss signific result suggest ism may hold translat potenti neuropath pain relat applic may uniqu suit deliv multi modal therapeut benefit individu live sci | D013119;D062187;D009437 | T061;T047;T184;T037 |
36,228,585 | gut microbiom dysbiosi contribut abdomin aortic aneurysm promot neutrophil extracellular trap format abdomin aortic aneurysm aaa insidi lethal vascular diseas lack effect nonsurg intervent gut microbiota dysbiosi play key role mani diseas relationship aaa fulli elucid herein reveal signific abnorm gut microb composit aaa patient confirm gut microbiota dysbiosi import caus aaa specif r intestinali signific reduc aaa patient use aaa mice show r intestinali metabolit butyr signific reduc neutrophil infiltr nox depend neutrophil extracellular trap format inflamm abnorm phenotyp switch vascular smooth muscl cell aortic wall therebi mark allevi aaa develop research uncov role mechan gut microbiota aaa develop provid insight aaa prophylaxi microecolog perspect | D017544;D065206;D000069196 | T007;T001;T047;T026 |
36,228,584 | host happi hour phage cocktail target ibd associ microb bacteriophag therapi promis strategi treat bacteri infect sculpt microbiom recent cell paper federici et al demonstr klebsiella pneumonia phage cocktail specif remov pathobiont mous gut safeti persist therapeut phage shown phase trial | D001424;D001435;D015212;D000071059 | T061;T047;T005 |
36,228,583 | help commens hex regul gut immun recent scienc issu bousbain et al identifi n acetylhexosaminidas conserv antigen express commens drive expans differenti intestin intra epitheli cell protect gut inflamm | D013559;D001619 | T116;T126;T040;T070 |
36,228,582 | sens pattern overlap immun bacteria eukaryot pathogen associ molecular pattern recogn dedic receptor eukaryot trigger immun respons recent studi gao wilkinson strecker et al extend paradigm bacteria demonstr use similar receptor detect conserv phage protein activ analog immun viral invad | D001435;D056890 | T005;T204 |
36,228,581 | nod ligand becom antidot loss function mutat nod receptor sens microbiota deriv muropeptid genet predisposit crohn diseas cd issu cell host microb gao et al identifi microbiota deriv peptidoglycan remodel enzym dampen chronic intestin inflamm via nod offer potenti path allevi cd | D003424;D053473 | T047;T123;T116 |
36,228,580 | better live communal eat caenorhabd elegan grow either staphylococcus saprophyticus heat kill escherichia coli expos issu cell host microb geng colleagu identifi e coli deriv signal well host neural innat immun pathway promot digest saprophyticus | D029742;D004927 | T047;T116 |
36,228,579 | sow seed infect pathogen fungi remark abil undergo morpholog chang determin virul potenti issu cell host microb denham et al identifi fungal morphotyp uniqu adapt extrapulmonari dissemin contribut toward invas infect escap host immun respons | D000222;D005658 | T004;T040 |
36,228,578 | hybrid mental task base human comput interfac via integr pronunci motor imageri object among exist activ brain comput interfac bci motor imagin mi wide use oper mi bci effect subject need carri train correspond imagin task studi reduc discomfort fatigu activ bci imaginari task inabl concentr improv accuraci approach paper propos hybrid bci compos mi pronunci imagin pi electroencephalogram signal ten subject recogn adapt riemannian distanc classif improv frequenc select filter bank common spatial pattern recognit main result result show new paradigm combin mi pi recognit accuraci higher mi alon highest recognit rate propos hybrid system reach furthermor subject score result oper difficulti conclud design hybrid paradigm oper tradit bci paradigm signific separ task activ bci limit accuraci need improv new hybrid paradigm propos us improv accuraci oper activ bci system provid new possibl research direct activ bci | D062207 | T074 |
36,228,575 | develop mechanist understand clinic applic deep brain stimul parkinson diseas deep brain stimul dbs life chang treatment patient parkinson diseas pd give uniqu opportun direct explor basal ganglia work despit rapid technolog innov last year untap potenti dbs still high | D010300;D020531;D046690 | T061;T047;T023 |
36,228,573 | issfal statement number omega fatti acid pregnanc reduc preterm birth global preterm birth lead caus death children age year survivor may suffer life long consequ follow mani year investig strong evid proport preterm birth prevent increas matern dietari omega long chain polyunsatur fatti acid lcpufa intak pregnanc statement provid synthesi contemporari evid role omega lcpufa prevent preterm birth design provid fatti acid specif knowledg guidanc medic practition midwiv health servic profession bodi polici maker consid contextu situat evid synthesi underpin statement base cochran systemat review supplement evid rcts complet sinc time well systemat review heterogen studi explor understand effect omega supplement may vari differ popul group dose type omega supplement trial conduct upper middl high incom countri evid applic set evid synthesi confirm omega lcpufa particular docosahexaeno acid dha eicosapentaeno acid epa import role play determin gestat length singleton pregnanc adequ intak omega lcpufa earli pregnanc consist exist nutrit guidelin associ lower risk preterm earli preterm birth women singleton pregnanc therefor women adequ omega intak earli pregnanc maintain intak women low omega fatti acid benefit omega lcpufa supplement reduc risk earli birth case supplement total mg dha plus epa effect reduc risk earli birth prefer supplement commenc week gestat | D015525;D047928 | T121;T109;T123;T046 |
36,228,572 | determin barium sulfat barit ore phase convers partial pressur correct headspac gas chromatographi barium sulfat baso content use evalu grade barit ore present studi report method determin baso content barit ore phase convers headspac gas chromatographi partial pressur correct method ore sampl roast sodium carbon potassium carbon pretreat hydrochlor acid roast product subsequ place close headspac bottl react hydrochlor acid ratio co signal detect thermal conduct detector gas chromatographi final baso content barit ore calcul use ratio method demonstr good precis relat standard deviat accuraci relat error uncertainti confid interv approxim moreov approach expect use batch test baso content barit ore industri applic | D001466;D002245 | T123;T130;T197 |
36,228,571 | analysi purif ssrna dsrna molecul use asymmetr flow field flow fraction robust rna purif analysi method requir support develop rna vaccin therapeut well rna interfer base crop protect solut asymmetr flow field flow fraction af gentl nativ purif method appli liquid flow separ sampl compon base hydrodynam size recent show af util separ rna molecul shorter nucleotid nt perform af analysi purif longer rna molecul previous evalu studi perform af separ singl strand ss doubl strand ds rna molecul size rang nt addit evalu power af coupl differ detector allow separ combin data collect yield well molecular weight mw size distribut show af method applic rna purif qualiti control analyt result good recoveri ssrna dsrna molecul addit result demonstr util af multidetect platform studi biophys properti long rna molecul | D031521 | T059 |
36,228,570 | effect weight loss lifestyl chang heart rate variabl overweight obes patient systemat review effect calori restrict physic activ autonom regul cardiac vagal control overweight obes individu remain inconsist thus systemat review aim evalu weight loss effect lifestyl chang heart rate variabl hrv marker overweight obes subject | D050177;D015431 | T033 |
36,228,569 | gut microbiom mild cognit impair probiot random clinic trial middl age older adult advanc age coincid chang gut microbiom declin cognit abil psychobiot microbiota target intervent result mental health benefit protect age brain studi investig gut microbiom composit predict microbi function pathway middl age older adult met criteria mild cognit impair mci compar neurolog healthi individu investig impact probiot lactobacillus rhamnosus gg lgg doubl blind placebo control random clinic trial total communiti dwell middl age year older adult year receiv three month intervent random probiot placebo group particip subdivid base cognit status group intact impair cognit sampl collect baselin post supplement | D000069196;D019936;D052201;D060825 | T007;T001;T048 |
36,228,567 | effect aronia berri poli phenol supplement arteri function gut microbiom middl age men women result random control trial berri poli phenol consumpt associ cardioprotect benefit howev littl known role gut microbiom may play health benefit object investig effect aronia berri poli phenol consumpt cardiometabol health gut microbiom rich composit prehypertens middl age men women | D046936;D000069196 | T007;T001;T002 |
36,228,564 | urinari c megalin predict progress diabet kidney diseas exploratori retrospect cohort studi megalin proxim tubular endocytosi receptor excret urin two form ectodomain megalin full length c megalin explor whether urinari megalin level use independ prognost biomark progress diabet kidney diseas dkd | D003928;D003924 | T047 |
36,228,563 | post covid syndrom inflamm diabet rage covid pandem third year global impact sar cov virus high rate spread protean manifest high morbid mortal individu predispos risk factor pathophysiolog mechan involv heighten system inflammatori state cardiometabol derang vari degre glucos intoler latter evid signific hyperglycemia lead new onset diabet worsen preexist diseas unfortun clinic cours beyond acut phase ill may persist form varieti symptom togeth form call long covid post covid syndrom thought chronic low grade inflammatori immunolog state persist phase may last week month although numer insight gain covid relat hyperglycemia diabet predict cours manag remain fulli elucid | D000086382;D003920;D006943 | T047;T067;T033 |
36,228,562 | diabet treatment ischem stroke white paper examin current challeng treat ischem stroke diabet patient need greater understand mechan underli relationship diabet cerebr vascular respons ischemia discuss critic need improv efficaci safeti thrombolysi address need better character target action tpa current approv thrombolyt treatment ischem stroke | D002545;D000083242;D020521;D003920 | T047;T046 |
36,228,545 | enhanc activ thermost aspergillus niger atcc phytas ration design aspergillus niger atcc phytas produc penicillium verruculosum enzym found two ph optima well optimum c two amino acid substitut sp design improv thermost two nk dn design improv enzym activ thermost variant sp character fold increas time half life c fold increas residu activ c compar wild type activ variant dn time activ c retain time higher residu activ c compar wild type obtain result reveal import substitut prolin helix thermost improv phytas also import sequenc motif hdn demonstr relev valu catalyt paramet | D010832 | T126;T116 |
36,228,544 | glycosphingolipid form characterist size liposom correl antibodi induc activ mice immun mice liposom consist dipalmitoylphosphatidylcholin cholesterol lipid glycosphingolipid gsls effici induc product antibodi recogn specif gsls analyz effect gsl speci particl size gsl contain liposom prepar liposom contain gbcerglobosid gm sever artifici gsls analyz particl size phosphat buffer salin dynam light scatter particl size liposom signific alter addit gsls form nm particl size depend constitu gsl speci compar size gsl contain liposom igm igg induc activ liposom mice found posit correl increas liposom size igg induc activ also determin nucleotid sequenc heavi light chain variabl region anti gbcer igm igg obtain gbcer contain liposom immun mice found compos differ gene segment result indic gsl contain liposom induc product igg immun pathway differ igm rather effici induc class switch | D006028;D008081 | T121;T109 |
36,228,543 | littl involv recycl amino acid proteasom proteolysi de novo protein synthesi myoblast integr essenti skelet muscl regener mani intracellular protein degrad proteasom convert amino acid aminopeptidas protein degrad pathway although previous report import myoblast integr involv mechan remain unclear studi focus reusabl proteolyt product elucid regulatori mechan protein synthesi mediat proteasom aminopeptidas proteasom inhibit decreas protein synthesi recycl amino acid deriv proteasom proteolysi reus de novo protein synthesi cc myoblast hand proteasom aminopeptidas inhibit decreas intracellular atp level cc myoblast therefor indic amino acid produc proteolyt system may reutil atp product metabol de novo protein synthesi find suggest proteasom aminopeptidas thought involv protein synthesi intracellular energi product recycl amino acid metabol therebi maintain myoblast integr | D046988;D000596 | T121;T126;T116;T123 |
36,228,542 | mir p reduc excess alkbh allevi inflamm oa target tnfrsf trigger nf b pathway microrna mirna one potent therapeut target osteoarthr oa identifi mir p protect phenotyp chondrocyt demonstr tnf receptor superfamili member tnfrsf target mir p bind utr region base dual luciferas report assay rna bind protein immunoprecipit rip assay addit experi prove tnfrsf trigger nf b pathway correl inflamm chondrocyt mir p overexpress knee mice allevi oa vivo moreov examin enzym level oa prove abnorm express ketoglutar depend dioxygenas alkb homolog alkbh contribut mir p decreas research illustr signific role mir p oa includ matur mechan protect phenotyp chondrocyt could new treatment target oa | D035683;D010003 | T047;T123;T114 |
36,228,541 | norkurarinon isoxanthohumol inhibit high glucos hypoxia induc angiogenesi via improv oxid stress regul autophagi human retin microvascular endotheli cell diabet retinopathi dr one serious complic diabet microangiopathi recent studi shown close associ high glucos induc oxid stress autophagi disord previous studi show various compound flavonoid sophora flavescen aiton extract use ethyl acet sfe could cross blood retin barrier exert favor effect retin tissu disord angiogenesi rat dr howev mechan specif materi basi sfe still unclear establish vitro dr model human retin microvascular endotheli cell hrmec induc high glucos hypoxia hgi screen potenti pharmacodynam compon sfe viz norkurarinon nkr isoxanthohumol ixm prove could improv patholog featur angiogenesi explor mechan action nkr ixm investig effect cellular oxid stress autophagi level hgi condit final role pikaktmtor signal pathway regul cell autophagi nkr ixm evalu collect nkr ixm could improv cellular oxid stress state activ pikaktmtor signal pathway regul autophagi dysregul thus play signific role protect hrmec hgi caus angiogenesi | D042783;D003930 | T025;T047 |
36,228,540 | extracellular vesicl deriv pinctada martensii mucus regul skin inflamm via nf bnlrpmapk pathway extracellular vesicl ev exosom subset vesicl like nanoparticl ev secret cell contain various factor treat various diseas howev studi extract ev marin shellfish still relat lack studi ev isol pinctada martensii mucus efficaci ev modul inflammatori environ demonstr human skin inflammatori cell model establish investig effect pinctada martensii mucus deriv ev inflamm result show ev could restor viabil inflammatori hacat cell decreas level reactiv oxygen speci ros well mrna express il il tnf inflamm hacat cell treat inhibit activ mapk nf b nlrp inflammasom signal pathway prevent phosphoryl relat inflammatori protein entri p protein nucleus studi provid novel ev marin shellfish deriv bioactiv materi | D003872;D000067128;D049911 | T047;T026;T204 |
36,228,539 | proton detect solut state nmr base scalar driven c overhaus dynam nuclear polar overhaus dynam nuclear polar odnp nmr solut high field usual mediat scalar coupl polar nuclei heavier electron rich atom leav h detect nmr outsid realm studi studi present experi deliv h detect nmr experi relat larg liquid volum l high field reli odnp enhanc end c nmr polar first enhanc reli mechan util e c scalar coupl interact nuclear spin align thus achiev pass neighbor h observ revers inept scheme reli one bond j ch coupl c h polar transfer port c odnp gain h permit detect higher frequenc higher potenti sensit model solut label chcl comix nitroxid base tempo deriv polar agent odnp enhanc factor ca x could thus impart h signal appli bigger organ molecul like c phenylacetylen c indol odnp enhanc x rang obtain thus although handicap lower c enhanc could impart h thermal acquisit case also find convent h c nuclear overhaus enhanc noe larg absent solut due presenc co dissolv radic ad neglig gain play neglig role scalar e c odnp transfer potenti ration effect well extens experi briefli discuss | D011522;D008279 | T059;T060;T196;T170 |
36,228,535 | half life measur sc sc half live sc sc measur follow decay rate use sever measur system two ionize chamber three spectrometri detector digit andor analogu electron sc result combin seven half life valu give result h agre last report valu h confirm near deviat recommend half life h scandium present impur product sc cyclotron proton irradi half life determin measur perform day end bomard eob sc decay neglig level seven measur combin obtain averag h agreement recommend valu h | D012538;D017357 | T074;T196;T073 |
36,228,534 | enhanc biosorpt europium cesium ion aqueous solut onto phalari seed peel environment friend biosorb equilibrium kinet studi sorption characterist eu iii cs remov aqueous solut estim use phalari seed peel powder psp novel biosorb econom low cost batch equilibrium experi carri investig effect contact time initi metal concentr media ph interfer ion sorption eu iii cs psp powder character via fourier transform infrar spectroscopi ftir thermogravimetr analysi tgdsc x ray diffract xrd scan electron microscop sem reveal chang adsorpt process indic like adsorpt taken place metal ion adsorb aqueous solut obtain result show eu iii higher select cs kinet adsorpt eu cs discuss shown second order kinet equat could describ sorption found best fit model r two metal ion langmuir dubinin radushkevich r isotherm found best fit r studi separ factor r l valu less indic biosorpt metal ion psp favor thermodynam paramet h g calcul use thermodynam equilibrium coeffici obtain differ temperatur obtain result indic endotherm natur sorption process metal ion onto psp psp powder potenti use low cost biosorb remov eu iii cs wastewat accord find | D031783;D014874 | T131;T002 |
36,228,532 | microencapsul bacteriophag incorpor feed salmonella control broiler bacteriophag inclus feed addit could offer prospect en mass applic reduc intestin carriag salmonella broiler chicken object studi evalu applic microencapsul phage strategi control salmonella assess impact use broiler rear period one hundr one day old chick random divid two ident poultri hous accord two experiment group control vs treat group simul field product condit half anim experiment group challeng cfubird salmonella enteritidi per os treat group microencapsul salmonella phage encapsul eudragitl ph respons formul incorpor starter diet feed assess salmonella colon excret diffus cecum sampl cloacal swab boot swab taken week salmonella detect base iso annex salmonella colon signific reduc rear period meanwhil excret signific reduc nd th th week rear moreov salmonella contamin farm environ elimin end cycl studi provid import insight potenti use phage prevent biocontrol strategi salmonella infect farm tabl | D012481;D011201;D001435 | T047;T005 |
36,228,521 | polygen co express chang testi growth hormon secret spermatogenesi prompt puberti hu sheep male mammal testi undergo increas prolifer activ onset spermatogenesi pubert develop howev gene express pattern role sheep remain unclear therefor use illumina hiseq sequenc identifi differenti express gene deg postnat day character transcript level sheep testicular develop among deg chang stage total deg identifi vs vs respect function enrich analysi reveal earlier pubert develop testi show higher gene express organ morphogenesi vasculogenesi neurogenesi hormon secret later pubert develop gene higher express main concentr regul spermatogenesi process result indic testi develop undergo transit organ growth spermatogenesi gene relat hormon secret express high earlier spermatogenesi pubert process addit found sever gene zfp tnf hsdb hsdb play key role androgen secret spag famili sycp famili spata famili spo cabyr tnp tnp cfap perform function spermatogenesi process taken togeth multi gene cooper prompt testi develop pubert process transcript atlas sheep testi provid comprehens insight testicular develop pubert process | D013737;D012741 | T023;T040 |
36,228,520 | use inject progesteron begin tai protocol necessari super earli resynchron start day artifici insemin bos indicus beef heifer protocol resynchron ovul start day time artifici insemin effect short action inject progesteron pi administr length treatment intravagin progesteron p devic follicular dynam concept rate pai percentag fals posit evalu nelor heifer previous time insemin p devic insert heifer alloc base factori design receiv pi mg pi nopi remov p devic day day day time p devic remov non pregnanc diagnosi perform use vascular corpus luteum vcl evalu time non pregnant heifer receiv g cloprostenol mg estradiol cypion iu ecg tai perform h p devic remov heifer ultrasound examin perform p devic remov tai evalu follicular dynam day tai evalu pai pregnant heifer base vcl evalu use b mode ultrasonographi day doppler ultrasound evalu percentag fals posit statist analys perform use glimmix procedur sas interact effect pi durat treatment p devic pai diagnos doppler st tai nd tai total percentag fals posit differ heifer receiv pi similar durat treatment p devic influenc pai doppler st tai nd tai total howev percentag fals posit diagnos higher day heifer p diamet largest follicl p devic remov greater day heifer p tai higher pi treat heifer p addit percentag fals posit diagnos lower heifer ovul st tai protocol p conclus resynchron day tai necessari inject pi begin protocol addit p devic remov instead day increas percentag fals posit earlier diagnosi day tai interfer pai resynchron protocol furthermor percentag fals posit higher heifer ovul st tai protocol | D011374;D004973 | T121;T109;T123;T067;T125 |
36,228,519 | structur biochem insight associ erap polymorph autoimmun diseas autoimmun diseas afflict near world popul serious impact surviv qualiti life unfortun specif pathogenesi almost autoimmun diseas still unclear research find identifi key pathogen gene genet level sever pathogen inflammatori factor phenotyp erap suggest potenti therapeut target sever autoimmun diseas especi mhc relat structur antigen peptid process function erap affect pathogenesi autoimmun diseas need elucid clear genet studi singl nucleotid polymorph erap provid good bridg better understand relationship pattern erap structur function diseas howev exist review focus genet associ erap snps autoimmun diseas one specif address erap gene polymorph embodi protein level specif mediat antigen peptid edit develop multipl autoimmun diseas paper present comprehens review erap snps associ multipl autoimmun diseas particular polymorph affect protein structur enzym function attempt unravel under structur biochem mechan erap affect pathogenesi multipl autoimmun diseas snp protein structur function diseas relationship studi provid theoret help idea understand relationship erap autoimmun diseas drug design target wild type mutant protein differ polymorph | D000626;D001327;D015778 | T047;T126;T116;T129 |
36,228,518 | oxygen boost biomimet nanoplatform synerget phototherapyferroptosi activ revers immun suppress tumor microenviron photodynam therapi pdt induc apoptosi cancer cell generat cytotox reactiv oxygen speci therapeut effect howev imped intrinsicinduc apoptosi resist mechan cancer cell hypoxia tumor microenviron tme also pdt induc anti tumor immun activ insuffici deal obstacl novel biomimet nanoplatform fabric precis deliveri photosensit chlorin e ce hemin pep cd inhibitori peptid integr oxygen boost pdt ferroptosi activ cd sirp blockad hemin catalas mimet activ allevi tme hypoxia enhanc pdt nanoplatform activ ferroptosi via classic regul glutathion peroxidas pathway non classic induc fe overload mode besid role hemin consum glutathion regul heme oxygenas express interest observ ce enhanc ferroptosi activ via classic non classic mode anti cancer immun reinforc combin pep mediat cd sirp blockad pdt mediat cell activ effici suppress primari tumor growth metastasi pep reveal first time sensit ferroptosi regul system xc work shed new light mechan pdt ferroptosi activ interplay bridg immunotherapi ferroptosi activ lay theoret foundat novel combin mode cancer treatment | D000079403;D002735;D011166;D010778 | T061;T043;T109;T123 |
36,228,517 | precis medicin guid co deliveri aspn sirna oxaliplatin nanoparticl overcom chemoresist colorect cancer develop chemoresist major hurdl treatment colorect cancer crc contribut remark poor clinic prognosi nanodrug deliveri system show great potenti overcom chemoresist limit lack identif chemoresist target cancer patient present studi enrol chemotherapi resist sensit crc patient use next generat rna sequenc reveal asporin aspn high express tumor tissu oxaliplatin oxa resist patient close correl poor prognosi crc downregul aspn revers oxa resist promot cell apoptosi vitro vivo overcom aspn mediat oxa resist construct nanoparticl base co deliveri system denot ppo siaspn simultan deliveri oxa sirna target aspn siaspn ppo siaspn facilit intracellular deliveri oxa enhanc cellular uptak effect suppress aspn express synergist antitumor activ vitro vivo clinic relev patient deriv xenograft pdx mous model system administr ppo siaspn achiev remark therapeut effect studi uncov critic role aspn caus oxa resist crc patient suggest promis nanoformul may effect current standard care medic | D015179;D053758 | T191;T073 |
36,228,516 | situ vaccin use dual respons organell target nanoreactor poor translat nanomedicin bench bedsid attribut lack deliveri system precis drug composit batch batch variat ii target undesir releas payload iii lack method monitor fate specif drug interest often modifi fluoresc tag replac model drug track overcom translat hurdl develop dual respons organell target nanoreactor drone precis drug composit site specif payload releas enabl accur vivo monitor drone consist polyprodrug inner core compos dual respons backbon contain photosensit protoporphyrin ix graft function polyethylen glycol peg outer shell prolong blood circul tumour home pro apoptot peptid cgkrk klaklak thp drone signific reduc tumour burden orthotop glioblastoma model due bbb penetr tumour home capabl drone exhibit good safeti profil biocompat along reliabl rout elimin drone show great potenti situ vaccin elimin tumour also trigger adapt immun respons would provid long term anti tumour immun | D005909;D053758 | T191;T073 |
36,228,513 | detect molecular character salmonella speci us goat oper salmonella speci import caus gastrointestin diseas anim includ goat addit salmonella speci among top five us foodborn pathogen caus ill human goat industri rapid expand us yet estim salmonella preval within popul lack aim studi investig fecal preval antimicrobi resist amr biofilm potenti virul profil salmonella speci isol goat fece part unit state depart agricultur usda nation anim health monitor system nahm goat studi enter microb compon total fecal sampl collect oper septemb march salmonella isol use standard enrich cultur method antimicrobi suscept determin broth microdilut biofilm product assess use crystal violet assay normal posit control strain pcr use detect virul gene overal detect low preval n salmonella goat fece identifi broad rang serotyp includ bareilli singl rare sharon isol pansuscept antimicrobi except one resist tetracyclin mic gml strain found possess major virul determin screen form weak moder strong biofilm found low preval salmonella characterist salmonella us goat popul inform ongo public health effort manag risk anim food product anim interact | D006041;D000890 | T121;T015 |
36,228,512 | estim transmiss paramet foot mouth diseas vietnam spatial dynam kernel base model outbreak host data foot mouth diseas fmd affect cloven hoof livestock caus devast damag world economi endem develop countri fmd impos signific threat fmd freedom status develop countri global concert effort erad fmd sourc face substanti challeng littl knowledg fmd spread develop countri far fmd virus transmiss paramet estim base dozen actual outbreak data most europ meanwhil fundament north south differ livestock product trade quarantin system question applic estim develop countri light aim narrow knowledg gap estim fmd virus transmiss paramet endem countri vietnam world fifth largest pork produc use spatial dynam kernel base approach combin daili fmd incurs data fmd host census data estim also consid livestock composit livestock quantiti speci influenc fmd transmiss line exist literatur find cattl buffalo larger influenc diseas spread pig fmd transmiss depend herd size distanc suscept infect premis howev find show fmd virus spread much ampl space case compar exist literatur km km versus km kernel much fatter tail differ like due weak biosecur system poor implement surveil quarantin measur bad husbandri practic swill feed preval develop countri thus estim kernel help vietnam develop suitabl biosecur measur contain erad fmd virus also high relev countri livestock farm practic climat condit similar vietnam | D005536;D029544;D002418;D013553 | T047;T005 |
36,228,511 | generat three human ipsc line patient huntington diseas differ cag length human control ipsc line healthi donor huntington diseas hd progress neurodegen disord autosom domin herit affect central nervous system peripher tissu human induc pluripot stem cell hipsc line generat dermal fibroblast patient without comorbid non smoker pre manifest iimcbi earli manifest iimcbi manifest iimcbi hd stage assess neurolog test well healthi donor iimcbi character show obtain hipsc line contain differ cag repeat consist number cag repeat origin fibroblast moreov hipsc express pluripot marker abl differenti three germ layer vitro | D057026;D006816 | T025;T047 |
36,228,507 | inhibit neointim hyperplasia balloon induc vascular injuri rat model mir load laponit hydrogel percutan coronari intervent pci mainstream treatment widen narrow obstruct coronari arteri due patholog condit howev post oper neointim hyperplasia occur endothelium denud surgic procedur follow inflamm microrna mir new therapeut great potenti cardiovascular diseas howev mir easili degrad vivo vehicl maintain bioactiv extend retent site deliveri prerequisit mir play role therapeut reagent report use laponit hydrogel deliv mir modul phenotyp smooth muscl cell smcs laponit hydrogel allow homogen distribut mir within gel capac transfect smcs vitro upon inject mir incorpor laponit hydrogel vivo mir could well retain surround arteri least day moreov mir load laponit hydrogel inhibit neointim format reduc infiltr macrophag revers advers vascular ecm remodel balloon induc vascular injuri upregul mir downregul target gene methyl cpg bind protein mecp applic laponit hydrogel mir local deliveri may offer novel strategi treat cardiovascular diseas | D057772;D062645;D002318;D035683 | T047;T037;T061;T123;T114 |
36,228,497 | mir p suppress breast cancer cell prolifer migrat invas regul bag microrna mirna involv progress divers human cancer work aim delv microrna p mir p affect biolog behavior breast cancer bc cell | D001943;D035683 | T191;T123;T114 |
36,228,485 | pyridoxin treatment levetiracetam induc behavior advers event random doubl blind placebo control trial levetiracetam broad spectrum antiseizur medic known behavior side effect possibl benefici effect pyridoxin improv psychiatr problem suggest previous studi clinic trial aim investig effect pyridoxin behavior side effect levetiracetam adult patient epilepsi | D010889;D004827;D064420 | T047;T046;T037;T121;T109;T033 |
36,228,484 | abnorm hemispher special drug nave drug receiv self limit epilepsi centrotempor spike self limit epilepsi centrotempor spike slect pediatr benign epilepsi often accompani subsequ adulthood function chang languag thought distinct area hemispher later function differenti studi aim explor hemispher special measur rest state function magnet reson imag rs fmri function connect drug nave drug receiv slect | D004292;D004827 | T047;T042;T033 |
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