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36,221,100
self referr associ factor among labor mother dilla univers referr hospit dilla gedeo zone ethiopia cross section studi medic case difficult manag level primari health care unit phcu formal referr assist patient transfer higher level care contrast self referr bypass synonym use literatur describ phenomenon patient skip unit get basic medic servic even though close resid though proper time referr prevent major death obstetr complic develop countri referr self referr trend patient practic increas becom concern mani health care system
D009035;D010342
T092;T058;T055;T099;T080
36,221,099
diagnost valu plasma p tau nfl gfap clinic set cohort preval neurodegen dementia increas evid support use plasma biomark neurodegener neuroinflamm screen diagnos patient dementia howev confirmatori studi requir demonstr use clinic set
D000544;D057180
T047;T048
36,221,098
neutral gm csf autoantibodi pulmonari alveolar proteinosi cryptococc mening sever nocardiosi anti gm csf autoantibodi aab relat acquir pulmonari alveolar proteinosi pap describ case sever infect cryptococcosi nocardiosi previous healthi subject whether differ anti gm csf autoantibodi correspond phenotyp unclear therefor examin anti gm csf autoantibodi determin whether amount neutral activ could distinguish group
D003453;D016919;D009617;D011649
T047
36,221,097
earli effect lps induc neuroinflamm rat hippocamp glycolyt pathway neuroinflamm common featur develop neurolog disord neurodegen diseas glial cell microglia astrocyt play key role activ mainten inflammatori respons central nervous system neuroinflamm known involv neurometabol shift addit increas energi consumpt use two approach vivo ex vivo evalu effect lipopolysaccharid lps induc neuroinflamm neurometabol reprogram modul glycolyt pathway neuroinflammatori respons investig inflammatori cytokin receptor rat hippocampus well marker glial reactiv mitochondri respirometri glycolyt pathway evalu multipl paramet includ enzymat activ gene express regul protein kinas metabol eg metformin po oxam acid fluorocitr inflammatori eg minocyclin mcc arund acid inhibitor use ex vivo hippocamp slice induct earli inflammatori chang lps vivo ex vivo enhanc glycolyt paramet glucos uptak pfk activ lactat releas increas glucos consumpt independ energi expenditur glutam uptak fact divert mainten immun respons accord inhibitor glycolyt pathway kreb cycl revert neuroinflamm reduc il sb chang glycolyt paramet induc lps acut hippocamp slice moreov inhibit sb protein predomin synthes secret astrocyt inhibit microglia activ abrog nlrp inflammasom assembl confirm role neuroinflamm upregul glycolysi hippocampus data indic neurometabol glycolyt shift induc inflammatori activ well central integr role astrocyt suggest interfer control neurometabol may promis strategi downregul neuroinflamm consequ diminish negat neurolog outcom
D008070;D008687
T121;T109
36,221,095
singl cell transcriptom reveal role macrophag nave cd cell interact immunosuppress microenviron primari liver carcinoma liver carcinoma general present immunosuppress microenviron promot tumor evas intercellular crosstalk immun cell signific influenc construct immunosuppress microenviron studi aim investig import interact immun cell target drug liver carcinoma use singl cell bulk transcriptom data
D006528;D034261;D008113
T191;T109;T121
36,221,094
characteris social contact covid control measur africa earli covid pandem countri adopt non pharmaceut intervent npis lockdown limit sar cov transmiss social contact studi help measur effect npis estim paramet model sar cov transmiss howev contact studi conduct africa
D000086382
T047;T067
36,221,093
associ long term exposur airborn pm compon mortal massachusett mixtur analysi explor numer studi document pm link advers health outcom compar fewer studi evalu specif pm compon lack exposur measur high correl among differ pm compon two limit
D000393;D000397;D002318;D005648;D012140
T047;T131;T069;T109;T080
36,221,092
establish recombinas polymeras amplif rpa fluoresc assay detect swine acut diarrhea syndrom coronavirus sad cov swine acut diarrhea syndrom coronavirus sad cov caus acut vomit diarrhea piglet lead signific financi loss pig industri recombinas polymeras amplif rpa rapid nucleic acid amplif technolog use constant temperatur condit studi establish real time revers transcript rt rpa assay earli diagnosi sad cov result detect limit real time rt rpa copiesl sad cov genom standard recombin plasmid case assay perform less min cross reaction observ eight common virus affect swine includ classic swine fever virus csfv porcin reproduct respiratori syndrom virus prrsv pseudo rabi virus prv swine influenza virus siv seneca valley virus sva transmiss gastroenter virus tgev porcin epidem diarrhea virus pedv porcin deltacoronavirus pdcov coeffici variat cv valu two standard dilut three posit clinic sampl rang total clinic fecal sampl swine diarrheal symptom analyz develop rt rpa quantit rt pcr agreement rt rpa quantit real time pcr result
D000073638;D018352;D009696;D013553
T047;T123;T005;T114
36,221,091
effect neuromuscular electr stimul serum glucos level children adolesc type diabet mellitus singl group clinic trial studi aim evalu effect neuromuscular electr stimul nmes serum glucos level children adolesc type diabet
D001786;D003922
T047;T109
36,221,090
bargain patriarchi life cours obstacl face overcom women leader kerala health sector covid pandem help shine spotlight role women leadership tackl world health health system challeng proport women occupi senior leadership posit health sector less compar male even constitut vast major work forc south indian state kerala except trend phenomenon sought understand contextualis undertook studi understand person profession journey women leader kerala health sector determin anteced leadership posit challeng came way leadership strategi adopt overcom challeng also investig experi shape style approach leadership
D000086382;D058873
T047;T067
36,221,089
everyth hujur tell educ appli life mean mix method process evalu smoke free home intervent bangladesh second hand smoke exposur tobacco signific contribut morbid mortal worldwid cluster rct bangladesh compar communiti base smoke free home sfh intervent deliv mosqu without indoor air qualiti iaq feedback household intervent neither effect cost effect compar intervent use object measur second hand smoke paper present process evalu embed within trial seek understand
D016902;D014028
T069;T080;T033
36,221,087
interprofession student led clinic volunt patient experi learn patient gain understand live experi play import role improv health profess educ howev opportun student engag interprofession learn activ involv patient partner remain limit develop interprofession student led clinic peopl live parkinson diseas voluntarili particip patient partner aim pilot studi explor patient experi motiv particip
D006282;D014838
T054;T097
36,221,086
clinic elect cours effect medic student graduat jordanian medic school elect cours part th year medic school curriculum jordan student choos specialti wish spend week choos locat even outsid univers affili hospit studi tri understand student choic regard countri elect chosen specialti type placement observershipclerkship elect general valu particip perspect
D004504;D013337
T065;T097
36,221,085
mainstream adult adhd primari care uk guidanc practic best practic recommend adhd adult common debilit neurodevelopment mental health condit yet diagnosi clinic manag monitor frequent constrain scarc resourc low capac specialist servic limit awar train primari secondari care result mani peopl adhd experi serious barrier access care need
D001289
T048
36,221,084
one step fabric lidocainecallispher composit painless transcathet arteri embol transcathet arteri embol tae one first line treatment advanc hepatocellular cancer pain caus tae stark complic remain prevent biomed engin method
D004621;D008012
T121;T061;T109
36,221,083
stuck medal particip institut theori perspect sport feder struggl reach sport goal sport emphas everi individu right particip sport despit effort deliv sport past decad studi indic sport particip rate stagnat wherea social inequ sport continu exist appli institut theori len studi shed light dual mission sport feder ie provid sport high perform sport affect sport project flemish sport feder eg amount project target group particular sport project reduc barrier engag sport system support sport feder furthermor studi seek better understand impact under institut logic institut pressur legitimaci sport feder
D001363;D013177
T056;T073
36,221,082
impact volunt student run free clinic medic student specialti select shortag primari care physician unit state expect grow physician student run free clinic increas popular compon medic school may provid avenu increas medic student interest primari care specialti howev limit research impact student run free clinic medic student specialti choic investig sought determin whether volunt interprofession communiti clinic icc student run free clinic associ chicago medic school associ increas likelihood match primari care specialti secondarili author investig associ volunt match famili practic final author explor associ volunt competit specialti choic
D007396;D000070319;D013337
T065;T097;T073;T093
36,221,081
left ventricular non compact cardiomyopathi associ prkag mutat left ventricular non compact cardiomyopathi lvnc one common inherit cardiovascular diseas genet background lvnc patient fulli understood collect clinic data famili histori blood sampl perform genet analysi use next generat sequenc ngs chines famili subject clinic lvnc affect subject show mark cardiac phenotyp heterogen found subject lvnc carri missens heterozyg genet mutat cg prq subunit amp activ protein kinas prkag gene ngs individu without mutat show symptom cardiac structur abnorm relat lvnc one subject victim sudden cardiac death sum prkag mutat cg prq caus famili lvnc result describ potenti pathogen mutat associ lvnc may extend spectrum lvnc phenotyp relat prkag gene mutat
D055372;D009202
T047;T126;T116
36,221,080
alcohol consumpt pattern risk sarcopenia popul base cross section studi among chines women men henan provinc sarcopenia clinic relev syndrom health social econom implic alcohol consumpt one risk factor sarcopenia fulli investig chines popul purpos present studi assess relationship alcohol consumpt pattern includ volum frequenc alcohol consumpt sarcopenia element among chines women men henan provinc
D055948
T047
36,221,079
dna ligas iv difici elev serum igg level suspect myelodysplast syndrom case report ligas iv lig difici rare clinic syndrom around case report date syndrom caus biallel pathogen variant lig gene caus dna damag repair disord main manifest sever immunodefici
D007153;D009190;D010198;D014612
T047;T046;T116;T191;T121;T129
36,221,078
preval sexual harass among young spaniard covid lockdown period spain sexual harass type coercion includ social pressur intimid physic forc verbal act addit form cyber harass recogn major import public health problem
D000086382;D017406
T054;T047;T067
36,221,077
earli predict hemodialysi complic employ ensembl techniqu hemodialysi complic remain critic threat among dialysi patient result sudden termin session impact effici dialysi intra dialyt complic result interplay multipl factor artifici intellig aid earli predict research aim compar differ machin learn tool earli predict frequent hemodialysi complic high perform use fewest predictor easier practic implement
D001185;D000069550
T090;T066;T073
36,221,076
anatom distanc affect function connect rest medicin free obsess compuls disord brain function abnorm rest observ obsess compuls disord ocd howev whether anatom distanc influenc function connect fc rest ambigu ocd
D001931;D009771
T062;T060;T048
36,221,075
associ klotho subclin carotid atherosclerosi subject type diabet mellitus compel evid suggest fibroblast growth factor fgf klotho axi impair subject diabet mellitus examin relationship paramet relat calciumphosph homeostasi includ fgf klotho subclin carotid atherosclerosi burden type diabet mellitus td subject
D002340;D003922;D058226
T031;T047;T046;T020
36,221,074
multi drug resist bacteria isol lymphat filariasi patient ahanta west district ghana antimicrobi resist associ increas morbid secondari infect global threat own ubiquit natur resist gene environ recent estim put death associ bacteri antimicrobi resist million worldwid lymphat filariasi lf neglect tropic diseas ntd associ poor live tropic region world lf patient prone develop acut dermatolymphangioaden adla condit put risk develop secondari bacteri infect due skin peel adla particular worsen prognosi patient lead usag antibiot therapeut intervent may result inappropri usag antibiot due self medic non complianc exacerb antimicrobi resist lf patient perspect assess possibl antimicrobi resist lf patient focus antibiot usag antibiot resist staphylococcus aureus escherichia coli pseudomona aeruginosa isol look gene meca extend spectrum beta lactamas blactx blashv blatem code resist multi drug resist mdr bacteri isol
D004605;D004927;D055624;D013203
T007;T047
36,221,073
associ triglycerid glucos index atherosclerot plaqu burden find communiti base studi insulin resist import caus cardiovascular event cerebr infarct develop aim investig associ triglycerid glucos tyg index atherosclerot burden plaqu coronari intra extracrani arteri particip non diabet compar result homeostasi model assess insulin resist homa ir
D050197;D007333;D058226
T031;T047;T046;T020
36,221,072
ef promot cell cycl progress stabil spindl fiber colorect cancer cell ef transcript factor regul cell cycl progress high express cancer cell activ transcript cell cycl relat kinas stathmin transform acid coil coil contain protein tacc factor enhanc stabil spindl fiber
D015179;D008941
T191;T026
36,221,071
pre referr intranas artesun powder cerebr malaria proof concept studi malaria still kill young children rural endem area earli treatment avail thus world health organ recommend administr artesun suppositori pre referr treatment transport hospit case sever symptom unavail parenter oral treatment howev negat cultur percept rectal rout limit access artesun suppositori could limit use artesun suppositori therefor need altern rout malaria pre referr treatment aim studi assess potenti intranas rout malaria pre referr treatment
D000962;D037621;D016779
T121;T047;T109
36,221,070
complementari medicin usag surgeri cross section survey germani complementari medicin cm frequent use patient littl known usag cm surgic patient studi aim elucid relev cm surgeri
D000529
T061;T091
36,221,069
larrpm restrict lung adenocarcinoma progress macrophag polar epigenet regul linc csf long non code rnas lncrnas critic regul lung adenocarcinoma luad type tumor associ macrophag tam also play oncogen role luad howev involv lncrnas tam activ still larg unknown
D000230;D008175;D062085
T191;T123;T114
36,221,068
factor associ non use insecticid treat bed net among pregnant women zambia despit zambian govern effort ensur use insecticid treat net itn among pregnant women itn use remain critic low pregnant women report sleep itn countri studi aim determin preval factor associ non use itn among pregnant women zambia
D057148;D007306;D008288
T047;T074;T131
36,221,067
compar analysi endophyt bacteria inhabit phyllospher aquat fern azolla speci high throughput sequenc azolla small float fern live symbiosi nitrogen fix cyanobacteria provid varieti import ecosystem benefit previous studi present azolla harbor divers bacteria may play key role host fit product howev characterist endophyt bacteria inhabit phyllospher differ speci azolla yet fulli understood
D000458;D029624
T007;T002
36,221,066
deep learn algorithm reveal two prognost subtyp patient glioma glioma high complex heterogen tumor render prognosi predict challeng advent deep learn algorithm access multi omic data repres new approach identif surviv sensit subtyp herein autoencod base approach use identifi two surviv sensit subtyp use rna sequenc rna seq dna methyl dnam data cancer genom atlas tcga dataset subtyp use label build support vector machin model cross valid valid robust model chines glioma genom atlas cgga dataset dnam driven gene identifi integr dnam gene express profil analys use r methylmix packag carri enrich analysi
D000077321;D005910
T191;T066
36,221,065
examin relationship perceiv neighborhood social cohes ideal cardiovascular health whether psychosoci stressor modifi observ relationship among jhs mesa masala particip psychosoci stressor increas risk cardiovascular diseas across divers popul howev neighborhood level resili resourc may protect poor cardiovascular health cvh studi use data three cvh cohort examin longitudin associ resili resourc perceiv neighborhood social cohes hereaft refer neighborhood social cohes american heart associ life simpl ls whether psychosoci stressor modifi observ relationship
D050197;D002318
T047;T046
36,221,064
associ serum klotho level cardiovascular diseas risk factor older adult klotho defici signific predictor cardiovascular diseas cvd relat mortal morbid howev research assess associ klotho individu risk factor cvd limit studi aim explor associ circul serum klotho level risk factor cvd adult
D002318;D050171
T047;T046
36,221,063
preval extend spectrum lactamas ampc carbapenemas proteus mirabili clinic isol proteus mirabili opportunist pathogen caus varieti communiti acquir nosocomi ill pose potenti threat patient via product lactamas decreas efficaci antimicrobi treatment impair manag pathogen henc studi establish determin preval extend spectrum lactamas esbl ampc carbapenemas p mirabili isol various clinic specimen
D011513;D015662
T007;T109;T121
36,221,062
safeti novel esat cfp skin test compar tuberculin skin test doubl blind random control studi esat cfp ec skin test report accur safe identifi tuberculosi infect aim demonstr safeti ec skin test compar tuberculin skin test tst univers freshmen
D055985;D014376
T047
36,221,061
synergist effect depress moder chronic kidney diseas caus cardiovascular diseas mortal among adult retrospect cohort studi relationship coexist depress moder chronic kidney diseas ckd mortal unclear aim investig whether synergist effect depress moder ckd caus cardiovascular diseas cvd mortal among adult
D002318;D051436
T047
36,221,060
difficult intub postop aspir pneumonia associ moebius syndrom case report moebius syndrom rare congenit disord character non progress palsi abducen vi facial vii cranial nerv common featur includ dysfunct associ cranial nerv orofaci abnorm skelet muscl hypotonia system disord differ sever sever concern periop manag patient moebius syndrom
D003680;D020331;D011015
T047
36,221,059
machin learn model identifi pre frailti communiti dwell older adult increas evid pre frailti manifest earli middl age understand factor contribut earli trajectori good health pre frailti middl age older adult need inform time prevent primari care intervent mitig earli declin futur frailti
D015673;D000073496
T047;T046;T184;T033
36,221,057
util diffus weight imag patient spinal cord infarct differ find neuromyel optica spectrum disord magnet reson imag mri play crucial role diagnos spinal cord infarct sci howev find often indistinguish intramedullari diseas neuromyel optica spectrum disord nmosd although diffus weight imag dwi promis techniqu util discrimin sci nmosd remain unclear dwi find acut nmosd lesion investig detail
D002537;D002546;D009471;D013119;D020760
T050;T047;T037
36,221,056
multidimension approach resili older adult despit covid research main focus age risk factor covid consequ howev older adult prove abil overcom advers along life resili protect variabl dampen impact stress base macleod et al approach aim analyz relationship older adult resili covid relat stressor well physic mental social characterist eight hundr eighti nine peopl age particip studi older particip women better perceiv health lose love one virus associ resili moreov higher level gratitud person growth life purpos lower level depress associ greater score resili studi offer chang perspect age perceiv posit viewpoint focus easili access resourc may help older adult cope advers situat
D000086382;D055500
T055;T047;T067
36,221,055
lncrna snhg promot develop oesophag squamous cell carcinoma interact eifa modul rhou mrna stabil numer studi reveal long noncod rnas lncrnas close relat develop mani diseas carcinogenesi howev specif biolog function molecular mechan oesophag squamous cell carcinoma escc remain unclear
D004938;D000077277;D062085
T191;T123;T114
36,221,054
transcriptom profil lung immun respons potenti relat acut respiratori distress syndrom forest musk deer forest musk deer endang speci global death captiv forest musk deer caus certain respiratori system diseas acut respiratori distress syndrom ard huge threat life forest muck deer breed depart
D003670;D012128
T015;T047
36,221,053
zinc oxid nanoparticl reduc biofilm format synerg antibiot action attenu staphylococcus aureus virul host import messag clinician biofilm relat infect difficult treat higher resist antimicrobi agent current studi aim character influenc zinc oxid nanoparticl zno nps aureus suscept antibiot pathogenesi
D053768;D053758;D013203;D015034
T121;T047;T073;T197
36,221,052
long non code rna lncmyoz mediat ahcymyoz axi promot adipogen differenti porcin preadipocyt long non code rnas lncrnas play vital role regul adipogenesi howev associ regulatori mechan yet describ detail pig studi demonstr critic role lncmyoz adipogenesi porcin preadipocyt specif lncmyoz abund adipos tissu mashen fat type pig larg white lean type pig knockdown lncrna signific inhibit differenti porcin preadipocyt adipocyt mechanist use rna pull rip assay establish lncmyoz interact adenosylhomocysteinas ahci moreov lncmyoz knockdown increas promot methyl target gene myoz lower express final describ posit regulatori role myoz adipogenesi collect find establish lncmyoz import epigenet regul adipogenesi via aforement ahcymyoz pathway provid insight role lncrnas porcin adipos develop
D050156;D062085
T044;T123;T114
36,221,051
preval medic factor relat age among older car driver multicent cross section descript studi increas number older adult japan increas risk road traffic crash studi aim investig preval potenti under medic factor increas risk road traffic crash among older peopl
D001334;D000073496;D055948
T047;T046;T056;T184;T033
36,221,050
gray matter reduct bilater insula mediat advers psychiatr effect bodi mass index schizophrenia schizophrenia sz overweightobes owb shown structur alter similar brain region higher bodi mass index bmi often contribut wors psychiatr outcom sz studi design examin effect owb gray matter volum gmv patient sz
D066128;D012559
T023;T024;T048
36,221,049
novel six gene prognost signatur base colon adenocarcinoma immun relat gene colon adenocarcinoma coad one common gastrointestin tumor worldwid immunotherapi one promis treatment identifi immun gene involv develop mainten cancer key use tumor immunotherapi studi aim determin prognost valu immun gene patient coad establish immun relat gene signatur differenti express gene immun relat gene deig transcript factor detf screen use follow databas cistrom cancer genom atlas tcga immunolog databas analysi portal innatedb construct network show regul deig detf use weight gene co express network analysi prepar co express gene modul hub gene cda cdb fgf grp serpin frl obtain use univari multivari regress analysi use construct risk model patient tcga databas divid high low risk group base whether risk score greater less mean public dataset gse contain gene express profil colon cancer patient use valid
D000230;D003110
T191
36,221,048
associ gout develop parkinson diseas systemat review meta analysi natur antioxid uric acid play protect role neurodegen disord includ parkinson diseas pd therefor risk pd found lower peopl hyperuricemia articl conduct systemat review meta analysi investig whether gout affect futur risk develop pd
D006073;D010300
T047
36,221,047
global region nation earli onset colorect cancer burden trend result global burden diseas studi incid earli onset colorect cancer eo crc occur peopl age increas annual aim studi provid date estim global eo crc burden
D015179;D000071219
T191;T081
36,221,046
product characterist chemic composit vitro digest degrad kinet two brachiaria grass differ regrowth age studi aim effect differ regrowth age chemic product morpholog characterist addit kinet gas product vitro digest grass genus brachiaria treatment consist two regrowth age day two grass speci brachiaria brizantha b ruziziensi plat dimens four replic total plat complet random design regrowth age chang leaf stem ratio grass ruziziensi grass higher crude protein cp content leav marandu grass versus respect marandu grass leaf higher ndf content ruziziensi grass respect adf content respect accumul rate high marandu grass regardless age regrowth howev vitro digest dri matter ruziziensi grass better leaf stem regrowth age influenc dri matter dm neutral deterg fiber ndf vitro digest ivd leav ivdndf leav type grass similar increas ivddm stem regrowth age day dm degrad rate higher marandu grass regrowth age total gas product higher day paramet evalu dual pool logist model show interact age cultivar except fraction lag time total gas product marandu grass present greater volum gas rapid degrad fraction lower degrad rate signific interact paramet evalu model age grass exponenti model show interact fraction grass reduc cp content increas fibrous fraction function age reduct leaf dm ndf digest ruziziensi grass higher digest regrowth age evalu marandu grass higher yield recommend adjust vitro degrad kinet dual pool logist model
D035201;D006109
T002
36,221,038
rose bengal inhibit amyloid oligom induc tau hyperphosphoryl via act akt cdk kinas tau hyperphosphoryl aggreg consid main patholog mechan under alzheim diseas ad rose bengal rb synthet dye use diseas diagnosi report inhibit tau toxic via inhibit tau aggreg drosophila howev unknown rb could produc anti ad effect rodent
D016229;D000544
T047;T116;T048
36,221,032
neurocognit analys reveal video game player exhibit enhanc implicit tempor process win action video game requir predict time event order react fast enough game repeat wait enemi may help develop implicit incident prepar mechan compar action video game player non video game player reaction time task involv implicit time prepar explicit conscious tempor attent cue particip immers virtual realiti instruct respond visual target appear variabl delay warn signal half trial explicit cue indic target would occur warn signal behavior oculomotor eeg data consist indic compar non video game player video game player better prepar time use implicit mechan shed light neglect role implicit time relat electrophysiolog mechan game research result suggest game base intervent may help remedi implicit time disord found psychiatr popul
D013998;D018910
T041;T073
36,221,030
detect categor sever cardiac disord base sole heart period measur cardiac disord common condit associ high mortal rate due potenti caus serious symptom desir constant monitor cardiac status use access devic smartwatch electrocardiogram ecg make detail diagnosi cardiac disord examin typic perform year individu health checkup requir expert medic practition make comprehens judgment describ newli develop autom system alert individu cardiac disord sole measur seri heart period purpos examin two metric heart rate variabl hrv analyz day ecg record subject total found metric local variat effici convent hrv metric alert cardiac disord furthermor newli introduc metric local global variat result superior capac discrimin prematur contract atrial fibril even minut record heart period new detect system diagnost perform even better convent analysi method appli day record
D001281;D006331
T047;T046
36,221,029
local monitor sar cov variant two larg california counti coronavirus diseas covid caus sever acut respiratori syndrom coronavirus sar cov continu persist due mutat result newer infecti variant concern aim leverag ongo privat sar cov test laboratori infrastructur monitor sar cov variant two larg california counti studi enrol offer adult age year older los angel counti riversid counti recent test posit sar cov polymeras chain reaction pcr assay cycl threshold valu less equal cycl consid posit test sequenc purpos within day studi enrol clinician monitor self collect oral fluid anterior nare swab specimen obtain particip specimen transport store c cooler sampl underw ribonucl acid extract librari prepar sequenc sar cov lineag identifi use sequenc data particip genom data analyz use statist tool visual toolkit studi approv advarra institut review board pro may septemb individu enrol underw specimen collect particip particip women particip vaccin particip hispan spanish origin cohort particip symptom time collect among sampl nasal specimen oral specimen yield posit sequenc result studi period preval alpha variant sar cov decreas initi confid interv ci ci preval delta variant sar cov increas initi ci ci strain carri mutat delta mu identifi found outpati sar cov variant surveil could conduct time accur manner preval differ variant chang time higher proport nasal specimen yield result versus oral specimen time region outpati sar cov variant surveil could use public health effort identifi chang sar cov strain epidemiolog
D000086382;D000086402
T047;T067;T005
36,221,015
dna fingerprint use box ar gtg primer identifi spatial variat fecal contamin along pasig river philippin pasig river one econom import river metro manila philippin travers region major citi strateg locat util mean transport sourc water domest industri use recreat purpos howev due popul growth industri land use river water qualiti deterior wast pollut river pose health risk peopl benefit prevent river degrad essenti identifi origin contamin studi sourc fecal contamin pasig river identifi use box ar gtg primer dna fingerprint escherichia coli isol river result show domin human contamin percent composit follow agricultur sourc percent composit lowest sewag percent composit result research help evalu public health risk use scientif basi policymak implement rehabilit improv pasig river
D016172;D045483
T070;T063;T034
36,221,013
integrin alpha emerg key therapeut target reduc metastasi rhabdomyosarcoma neuroblastoma major current cancer therapi aim reduc tumour growth lack viabl pharmacolog option reduc format metastasi paradox sinc cancer death attribut metastat progress integrin alpha itga previous describ play essenti role metastasi howev littl known mechan link protein process one less studi integrin deciph import itga metastasi provid evid demonstr essenti metastat dissemin rhabdomyosarcoma neuroblastoma howev translat advanc studi reveal first time possibl reduc metastasi pharmacolog inhibit itga synthet peptid simul key interact domain adam protein experiment metastasi model childhood cancer also breast cancer model
D009447;D012208
T191
36,221,011
effici evalu sewag treatment plant delhi india use toler base data envelop analysi correct effect perform evalu wastewat treatment plant tough task complex biolog physico chemic biochem process associ variabl affect perform convent effici sewag treatment plant stps obtain use index relat pollut remov effici energi use cost indic consid one variabl time lead incorrect assess effici turn could advers affect decis make regulatori author data envelop analysi dea method util linear program techniqu handl multipl inputoutput variabl without requir cost function make appropri tool assess relat effici treatment plant present studi assess effici stps delhi india use toler base dea model util variabl return scale vrs uncertainti incorpor model use toler measur model solv use add option spreadsheet toolbox excel solver result reveal plant consid studi perform well observ slight chang input data lead instabl effici result last rank use determin treatment plant best effici scenario larger period year studi help chalk best manag practic could adopt regulatori author
D004785;D018508
T057;T131;T052
36,221,000
mitig acut chemotherapi associ advers event patient cancer despit enthusiasm surround novel target agent immunotherapi chemotherapi remain mainstay treatment human malign either alon combin yet burden chemotherapi associ advers event caae remain high import associ consider morbid mortal cost affect patient across multipl dimens includ physic emot social function caae direct affect patient outcom indirect increas risk cancer recurr compromis treatment intens continu systemat effort identifi critic summar evid manag approach caae remain limit herein review common acut caae major effect surviv qualiti life function andor continu optim therapi focus select acut toxic occur treatment summar under pathophysiolog multifactori aetiolog evidenc base treatment prevent strategi manag recommend also summar avail evid risk factor valid risk assess tool effort optim symptom control patient like benefit order person prevent treatment acut caae final discuss innov symptom monitor support care intervent develop improv outcom patient cancer
D009369;D000970
T191;T109;T121
36,220,999
autophagi inhibit impair leukemia stem cell function flt itd aml antagonist interact tyrosin kinas inhibit flt itd mutat associ poor prognosi acut myeloid leukemia aml flt tyrosin kinas inhibitor tkis demonstr clinic efficaci fail target leukemia stem cell lsc generat sustain respons autophagi import cellular stress respons contribut hematopoiet stem cell hsc mainten promot leukemia develop investig role autophagi regul flt itd aml stem cell function respons tki treatment show autophagi inhibit reduc quiescenc deplet repopul potenti flt itd aml lsc associ mitochondri accumul increas oxid phosphoryl howev tki treatment reduc mitochondri respir unexpect antagon effect autophagi inhibit lsc attrit show tki mediat target aml lsc commit progenitor p depend autophagi inhibit enhanc p activ increas tki mediat target aml progenitor decreas p activ lsc reduc tki mediat lsc inhibit result provid new insight role autophagi differenti regul aml stem progenitor cell reveal unexpect antagonist effect combin oncogen tyrosin kinas inhibit autophagi inhibit aml lsc suggest altern approach target aml lsc quiescenc regen potenti
D011505;D015470
T191;T126;T116
36,220,998
feasibl studi assess mediterranean diet adher use ai power system mediterranean diet md play major role decreas risk non communic diseas prevent overweight obes order person follow md assess adher proper dietari assess method requir develop artifici intellig power system recogn food drink item singl meal photo estim respect serv size integr smartphon applic automat calcul md adher score output week feedback report compar md adher score four user calcul system versus expert dietitian mean differ statist signific afterward conduct feasibl studi particip evalu system perform gather user dietitian feedback imag recognit system achiev mean averag precis test set feasibl studi imag ground truth taken particip annot feedback particip feasibl studi also posit
D038441
T061
36,220,997
breast cancer knowledg understand treatment rational among divers breast cancer survivor degre breast cancer survivor know tumor understand treatment rational well understood sought identifi inform gap within divers sampl explor whether knowledg breast cancer treatment may impact care
D000073116;D001943
T191;T101;T201
36,220,996
epigenet regul b cell role autoimmun pathogenesi b cell play pivot role pathogenesi autoimmun diseas although previous studi shown mani genet polymorph associ b cell activ patient various autoimmun disord progress epigenet research reveal new mechan lead b cell hyperactiv epigenet mechan includ involv histon modif dna methyl noncod rnas regul b cell respons dysregul contribut pathogenesi autoimmun diseas patient autoimmun diseas show epigenet alter lead initi perpetu autoimmun inflamm moreov mani clinic anim model studi shown promis potenti epigenet therapi patient review present date overview epigenet mechan focus role regul function b cell subset furthermor discuss epigenet dysregul b cell highlight contribut develop autoimmun diseas base clinic preclin evid discuss novel epigenet biomark therapi patient autoimmun disord
D044127;D001327
T047;T045
36,220,994
tumor extracellular vesicl mediat anti pd l therapi resist decoy anti pd l pd l tumor deriv extracellular vesicl tev caus system immunosuppress possibl resist anti pd l antibodi pd l blockad howev whether pd l tev mediat pd l therapi resist unknown show pd l tev substanti decoy pd l tev bound pd l rapid clear macrophag caus insuffici blockad tumor pd l subsequ pd l therapi resist inhibit endogen product tev raba coroa knockout revers pd l therapi resist either increas pd l dose macrophag deplet mediat clinic drug pexidartinib abolish pd l therapi resist moreov treatment cycl total treatment dose pd l high dose low frequenc treatment better antitumor effect low dose high frequenc treatment induc stronger antitumor immun memori elimin pd l therapi resist notabl human immun system mice human xenograft tumor increas pd l dose high dose low frequenc treatment enhanc antitumor effect pd l furthermor increas dose pd l pd compar antitumor effect pd l amplifi fewer pd treg cell respons tumor hyperprogress altogeth result reveal tev mediat mechan pd l specif therapi resist thus provid promis strategi improv pd l efficaci
D009369;D000067128
T191;T026
36,220,993
tripl rbd base mucos vaccin provid broad protect sar cov variant concern rapid mutat spread sar cov variant urg develop effect mucos vaccin provid broad spectrum protect initi infect therebi curb transmiss potenti design chimer tripl rbd immunogen ro nc harbor one delta rbd two omicron rbds within novel protein scaffold ro nc elicit potent broad rbd specif neutral immun sar cov variant concern notabl intranas immun ro nc plus mucos adjuv kfd ro nc kfdin elicit coordin mucos iga higher neutral antibodi specif closer antigen distanc omicron variant omicron challeng human ace transgen mice ro nc kfdin immun signific reduc tissu patholog lung lower viral rna copi number lung fold nasal turbin fold nasal virolog control high correl rbd specif secretori iga antibodi data show ro nc plus kfd promis mucos vaccin candid protect sar cov omicron infect patholog transmiss potenti
D000086382;D000086663
T047;T200;T067
36,220,992
detect iron bear miner assemblag nainarmalai granulit region south india base satellit imag process geochem anomali although india larg iron ore reserv well known still studi research iron ore prospect smaller deposit deposit lower grade remot sens concept use target miner explor sinc cover larg area low cost research spectral remot sens digit imag process aster data locat delin region iron oxid bear soil granulit terrain nainnarmalai southern india hypothet reserv million ton iron sub surfac band magnetit quartzit imag base studi compon involv pre process atmospher correct process imag data reminisc band ratio band mixtur locat iron bear soil use blend band delin ferrous iron oxid band combin delin ferric iron oxid band ratio delin laterit soil linear spectral unmix outcom asrer data evalu concern ground truth geochem composit sampl studi area result show imag process aster satellit data potenti delin ferric ferrous laterit miner assemblag iron bear soil minim requir ground truth verif research work aid increas trust use space base data miner prospect imag process demonstr aster data use enhanc iron ore explor discoveri new miner area
D052203;D007501
T121;T123;T197;T196
36,220,981
associ methyl donor nutrient metabol health status overweight obes adolesc limit evid avail regard associ methyl donor nutrient adolesc metabol health therefor investig relat combin methyl donor nutrient metabol health status overweight obes iranian adolesc cross section studi overweightobes adolesc includ use multistag cluster random sampl method dietari intak assess valid food frequenc questionnair methyl donor nutrient score mdns construct base decil vitamin b b b b methionin cholin betain glycem profil lipid profil blood pressur anthropometr indic collect particip classifi metabol healthi obes unhealthi obes muo base intern diabet feder idf idfhomeostasi model assess insulin resist homa ir definit mean age adolesc formula see text girl control confound individu top tertil mdns lower odd muo ci accord ifd criteria consid idfhoma ir criteria invers margin signific associ observ highest tertil mdns odd muo ci fulli adjust model furthermor signific invers associ found unit increas mdns odd muo base idf criteria idfhoma ir definit found overweightobes adolesc higher dietari intak methyl donor nutrient less like metabol unhealthi studi need confirm find
D007333;D024821;D063766
T047;T046;T033
36,220,979
mitochondri transport express pattern distinguish tumor normal tissu identifi cancer subtyp differ surviv metabol transport inner mitochondri membran essenti metabol demonstr metabol repres express gene encod slc transport differenti human cancer tumor normal tissu express ratio clear cell renal cell carcinoma colon adenocarcinoma lung adenocarcinoma breast invas carcinoma found high signific affin propag train slc gene express pattern human cancer type tcga sampl normal tissu gtex sampl use generat cluster differenti cancer normal tissu also indic cancer subtyp surviv distinct total patient popul cancer type probe kidney colon lung breast cancer cluster subtyp pair cancer identifi distinct prognos differ express protein code gene among metabol enzym assay demonstr slc express cluster facilit identif tissu origin essenti efficaci cancer therapi cup cancer unknown primari known poor prognos differ cancer type within singl cluster similar metabol pattern rais possibl cancer may respond similar exist new anti cancer therapi
D000230;D001943;D002292;D003110;D007680
T191
36,220,975
preclin efficaci cannabidiol treatment earli life seizur treatment epilepsi earli life pose uniqu challeng first line therapi leav mani individu poor control seizur respons pharmaco resist current first line anti seizur drug asd earli life new therapi emerg one therapi cannabidiol cbd well studi adult model epilepsi poor studi immatur anim assess efficaci cbd immatur rodent model epilepsi
D002185;D004827
T121;T047;T109;T033
36,220,974
use retinoid topic antiag treatment focus review clinic evid convent nanoformul nowaday numer skincar routin use rejuven age skin retinoid one popular ingredi use antiag treatment among repres retinoid tretinoin consid effect agent proven antiag effect skin found formul approv medicin topic treatment acn facial wrinkl hyperpigment retinoid present topic medicin use various indic tazaroten also approv adjunct agent treatment facial fine wrinkl pigment common use retinoid retinol retinaldehyd retinyl palmit contain cosmeceut regul cosmet sinc clinic efficaci studi requir market cosmet formul concern efficaci retinoid formul perspect retinoid pose challeng research result proven instabl low penetr potenti skin irrit therefor novel deliveri system base nanotechnolog develop overcom limit convent formul improv user complianc review clinic evid retinoid convent nanoformul topic antiag treatment evalu addit overview comparison clinic trial tretinoin retinoid present general lack evid proper design clinic trial support claim efficaci common use retinoid antiag agent cosmeceut retinoid contain medicin tazaroten adapalen clinic evalu antiag effect compar tretinoin may consid potenti altern antiag treatment promis potenti retinoid nanoformul requir comprehens evalu addit studi support preliminari find
D003879;D000068937
T121;T073
36,220,966
full length versus intact pth concentr pseudohypoparathyroid type primari hyperparathyroid clinic evalu immunoassay individu china applic third generat parathyroid hormon pth assay pth assay evalu pth level patient pseudohypoparathyroid type php less popular second generat assay therefor aim examin conform pth assay intact pth ipth assay specif examin perform individu php versus individu primari hyperparathyroid phpt compar healthi control
D049950;D011547
T047
36,220,965
matter space spatial heterogen energi deposit determin biolog outcom radiat exposur outcom exposur live organ ioniz radiat determin distribut associ energi deposit differ spatial scale radiat proceed ionize excit hit molecul nm space approach nanodosimetrymicrodosimetri mont carlo track structur simul success adopt investig radiat qualiti effect allow explor correl spatial cluster energi deposit scale dna chromosom domain biolog consequ cellular level physic featur alon howev enough assess entiti complex radiat induc dna damag latter result interplay radiat track structur spatial architectur chromatin depend chromatin dynam respons affect activ effici repair machineri heterogen radiat energi deposit singl cell level affect trade cell inactiv induct viabl mutat henc influenc radiat induc carcinogenesi radiat therapi goal cancer cell inactiv deliveri homogen dose tumour tradit approach clinic practic howev evid accumul introduc heterogen spatial fraction beam mini microbeam therapi lead signific advantag particular spare normal tissu find explain mere physic term interpret requir consid scale play under biolog mechan suggest system respons radiat
D011839;D000069079
T037;T070
36,220,940
unusu case transient cardiac calcif identifi antenat echocardiographi general arteri calcif infanc gaci like present generalis arteri calcif infanc gaci ultra rare life threaten genet disord arteri calcif identifi foetal ultrasound scan uss increas cardiac andor vascular echogen inorgan pyrophosph pp main inhibitor arteri calcif pathogen variant enpp abcc nte caus low pp lead ectop calcif rheumatoid arthriti ra acquir condit also lead arteri calcif adult present extrem rare case transient gaci like condit identifi foetal echocardiogram infant born mother diagnos ra spontan resolv postnat case highlight foetal ultrasound scan pregnant women ra care evalu cardiovascular calcif
D011755;D061205
T047;T126;T116
36,220,938
function order topographi brain network associ gene express heterogen human cerebr cortex vast expand relat nonhuman primat rodent lead function order topographi brain network show function topographi may associ gene express heterogen neocortex exhibit greater heterogen gene express lower express housekeep gene longer mean path length fewer cluster lower degre order network archicort subcort area human rhesus macaqu mous brain particular cerebellar cortex display greater heterogen gene express cerebellar deep nuclei human brain mous brain correspond emerg novel function human cerebellar cortex moreov cortic area greater heterogen primarili locat multimod associ cortex tend express gene higher evolutionari rate exhibit higher degre function connect measur rest state fmri impli spatial distribut gene express may shape evolut favour special higher cognit function togeth cross speci imag genet find may provid converg evid support associ order topographi brain function network gene express
D001931;D019579
T023;T062;T060;T024
36,220,937
growth perform south african windsnyer pig dietari inclus amarula oil cake dietari inclus amarula oil cake aoc pig diet eas pressur reli non nativ feed sourc benefit swine industri studi conduct determin growth perform windsnyer pig fed increas level aoc twenti five clinic grow male boar initi bodi weight kg use studi last week pig alloc diet complet randomis design five experiment diet formul contain gkg dm aoc averag daili feed intak adfi averag daili gain adg feed convers ratio fcr scale averag daili feed intak sadfi scale averag daili gain sadg bodi weight bw calcul week diet affect adfi adg fcr sadg p signific interact aoc inclus week feed adfi adg fcr p age pig decreas fcr quadrat p quadrat relationship adfi increas level aoc observ p averag daili gain fcr sadg decreas linear increas aoc level p use broken stick analys maximum inclus aoc gkg dm amarula oil cake incorpor diet windsnyer pig gkg dm without constrain growth perform
D000821;D000824
T168;T040
36,220,934
spatiotempor assess groundwat qualiti central ganga plain india use multivari statist tool present studi water qualiti status sadar block pratapgarh district uttar pradesh india calcul water pollut index wpi use groundwat qualiti paramet ph turbid ec electr conduct tds total dissolv solid salin total hard ca k mg na cl f hco differ studi locat found sampl fall good moder pollut high pollut categori respect irrig suitabl groundwat also evalu use irrig suitabl paramet ie sodium absorpt ratio sar residu sodium carbon rsc permeabl index pi kelli ratio kr percentag sodium na magnesium hazard mh base analysi determin sampl suitabl irrig area irrig practic found unsuit kelli ratio mh rsc sampl wpi pearson correl matrix pca suggest signific linear relationship among water qualiti paramet base test result gibb plot indic major sampl fall evapor domin categori rest fall rock weather domin suggest complex geochem mechan activ studi area studi would help govern author would aid suggest altern drink water resourc affect area
D060766;D060587;D014874
T167;T131;T081;T082;T070
36,220,932
function character maltodextrin glucosidas maltodextrin glycogen metabol vibrio vulnificus mo glycogen import transmiss v vulnificus undergo dispar environ nutrient rich host nutrient limit marin environ malz gene v vulnificus encod maltodextrin glucosidas clone express e coli investig role glycogenmaltodextrin metabol pathogen malz gene encod protein predict molecular mass kda optim ph temperatur malz c respect malz hydrolyz maltodextrin glucos maltos effici hydrolyz substrat starch maltos cyclomaltodextrin glycogen less effici activ enhanc great mn also exhibit transglycosyl activ toward excess maltotrios malz knock mutant accumul fold less glycogen wild type excess maltodextrin glucos ad lb medium accumul glycogen wild type fold presenc excess maltos growth glycogen accumul mutant retard signific minim medium supplement maltodextrin side chain length distribut glycogen molecul vari malz mutat type excess carbon sourc base result malz v vulnificus like involv maltosemaltodextrin metabol therebi balanc synthesi glycogen energi generat cell bacterium seem multipl uniqu pathway glycogen metabol accord carbon sourc
D029968;D041261
T007;T116
36,220,919
fit cost associ gaba receptor mutat confer dieldrin resist aed albopictus understand dynam insecticid resist gene mosquito popul pivot sustain use insecticid dieldrin resist aed albopictus confer alanin serin substitut rdlr allel aminobutyr acid gaba receptor encod rdl gene reunion island dieldrin resist initi report natur ae albopictus popul sampl despit ban dieldrin sinc monitor insecticid resist ae albopictus island identifi driver measur frequenc resist allel distinct natur popul collect ii fit cost associ dieldrin resist laboratori control experi iii resist confer rdlr fipronil insecticid wide use island report cross react rdlr result show persist rdlr ae albopictus natur popul low frequenc among measur life histori trait mortal pre imagin stage adult surviv well proport egg lay femal signific affect resist mosquito final bioassay reveal resist rdlr mosquito fipronil suggest use fipronil natura could select rdlr allel studi show dieldrin resist persist natur mosquito popul like result combin effect fit cost associ rdlr select exert cross react environment insecticid fipronil
D000330;D007306
T131;T204
36,220,912
heteropolyacid coupl cyanoguanidin decor magnet chitosan effici catalyst synthesi pyranochromen deriv studi novel nanocatalyst success prepar heteropolyacid immobil magnet chitosan cyanoguanidin composit fulli character differ analysi method includ ftir xrd tga sem ed catalyt activ fabric composit examin one pot three compon reaction involv divers activ methylen compound various aryl aldehyd malononitril water result reveal effici catalyt perform composit reaction proceed smooth led format correspond pyranochromen deriv high excel yield
D048271
T121;T109
36,220,911
flood map damag assess due super cyclon yaa use googl earth engin purba medinipur west bengal india studi map flood inund estim damag caus super cyclon yaa purba medinipur india use googl earth engin gee creat flood inund map research area use pre post cyclon sentinel sar data use esri land cover data flood damag analys flood affect km land purba medinipur northern southern region affect total flood area compris agricultur veget respect kolaghat km nandigram ii km sustain greatest damag agricultur veget area impact flood worst damag occur gee platform cost effect effici faster calcul enhanc precis outcom studi aid manag cyclon induc hazard advoc plant nativ salt toler crop reduc flood damag
D055867;D055868
T070
36,220,896
person identifi brainprint stabli embed eeg mindprint electroencephalographi eeg signal measur fix condit exploit biometr identifi howev contribut uniqu one brain signal remain unclear present research conduct multi task multi week eeg studi ten pair monozygot mz twin examin natur compon person identifi brain signal machin learn analys uncov person identifi eeg compon serv base signal share across task week task invari tempor stabil suggest person identifi eeg characterist structur brainprint function mindprint moreov base signal similar within mz twin still possibl distinguish twin sibl particular use eeg signal come primarili late rather earli develop area brain besid theoret clarif discoveri eeg base signal practic implic privaci protect applic brain comput interfac
D062207;D014429
T074;T099
36,220,895
distinct role ckm mediat control polycomb depend chromosom interact prime gene induct precis control gene express underpin normal develop reli mechan enabl communic gene promot regulatori element embryon stem cell esc cyclin depend kinas modul mediat complex ckm mediat report physic link gene regulatori element enabl gene express also prime gene induct differenti show ckm mediat contribut littl three dimension genom organ esc specif essenti role control interact inact gene regulatori element bound polycomb repress complex prcs interact establish canon prc cprc complex reli ckm mediat facilit bind cprc target site import separ function experi reveal collabor ckm mediat cprc creat long rang interact function prime gene induct differenti instead discov prime reli interact independ mechan wherebi ckm support core mediat engag gene promot differenti enabl gene activ
D056892;D063150
T123;T116
36,220,894
mio integr imag comput strategi model gene fold nucleosom resolut linear sequenc dna provid invalu inform gene regulatori element along chromosom howev fulli understand gene function regul need dissect gene physic fold three dimension nuclear space describ immuno oligostorm imag strategi reveal distribut nucleosom within specif gene super resolut simultan visual dna histon combin immuno oligostorm restraint base coars grain model approach integr super resolut imag data hi c contact frequenc deconvolut micrococc nucleas sequenc inform result method call model immuno oligostorm allow quantit model gene nucleosom resolut provid inform chromatin access regulatori factor rna polymeras ii model immuno oligostorm explor intercellular variabl transcript depend gene conform fold housekeep pluripot relat gene human pluripot differenti cell therebi obtain highest degre data integr achiev far knowledg
D008836;D009707
T126;T116;T123
36,220,893
nucleus transloc mitochondri cytochrom c liber nucleophosmin sequest arf tumor suppressor chang nucleolar liquid liquid phase separ regular function nucleolus nucleus mitochondria crosstalk consid unrel process yet cytochrom c cc migrat nucleus even nucleolus stress condit nucleolar liquid liquid phase separ usual serv cell fast smart mechan control spatial local traffick nuclear protein actual altern read frame arf tumor suppressor protein sequest nucleophosmin npm nucleoli shift npm upon dna damag dna damag also trigger earli transloc respiratori cc nucleus cytoplasm caspas activ show cc bind nucleolar npm trigger extend compact conform chang drive arf releas npm cc nucleolar interact extend general mechan dna damag lysin rich region cc rather canon arginin rich stretch membran less organell compon control traffick avail nucleolar protein
D045304;D000090243
T126;T123;T116
36,220,885
influenc self report histori mild traumat brain injuri cognit perform long term cognit consequ mild traumat brain injuri mtbi poor understood studi investig cognit perform chronic stage injuri hospit base popul base sampl reveal inconsist find import popul base mtbi sampl remain studi literatur studi investig cognit perform among individu histori self report mtbi use batteri cognit demand behaviour task import half mtbi particip experienc multipl mild head injuri compar control particip n particip histori mtbi n demonstr deficit work memori multitask abil cognit flexibl visuospati abil respons inhibit inform process speed social cognit moder evid mtbi group perform better control particip visual work memori measur overal find suggest even multipl instanc mtbi necessarili lead long term cognit impair group level thus provid import evid impact chronic mtbi across number cognit process popul base sampl studi necessari determin impact individu differ injuri relat variabl cognit perform chronic stage injuri
D001924;D003072
T048;T037
36,220,882
new diagnost criteria myelodysplasia relat acut myeloid leukemia use predict clinic outcom comparison th th world health organ classif mutat myelodysplasia relat mr gene rather morpholog featur includ diagnost criteria new th world health organ classif myelodysplast syndrom mds associ acut myeloid leukemia aml studi compar clinic relev new criteria previous version cohort patient newli diagnos aml mds relat aml patient classifi accord th th edit classif aml myelodysplasia relat aml mr th aml myelodysplasia relat chang aml mrc th respect median age patient year mr gene mutat found patient sixti one patient diagnos aml mrc th patient diagnos aml mr th patient aml mr th signific older signific lower treatment respons rate higher recurr rate shorter relaps free surviv chemotherapi wherea aml mrc th patient show associ treatment outcom overal follow prognost factor surviv identifi age year anteced mds mdsmyeloprolif neoplasm chromosom abnorm kras zszr mutat th classif use predict treatment respons patient aml mr previous version among mr gene zszr mutat found independ prognost factor affect surviv
D009190;D015470
T191;T046
36,220,881
iron chelat hetrombopag aplast anemia post hoc analysi phase ii studi hetrombopag cfda approv thrombopoietin tpo receptor agonist sever aplast anemia saa china chemic structur iron chelat domain explor iron chelat effect hetrombopag perform post hoc analysi phase ii clinic trial nct thirti five immunosuppress therapi ist refractori saa patient enrol studi longitudin chang serum ferritin sf assess week post hetrombopag initi patient show decreas sf level median baselin median sf decreas valu ngml rang ngml decreas sf found hematolog respond non respond among patient iron overload decreas sf level baselin patient normal sf level also show decreas sf level iron defici occur two patient conclus hetrombopag show power rapid iron chelat effect
D000741;D047069
T047;T109
36,220,880
arylcoumarin perturb sar cov pathogenesi target proteinac interact vaccin drive covid worldwid quit success howev second wave infect even disastr rapid increas reinfect human death due appear new sar cov variant viral genom mutat variant acquir pass differ human host could escap antibodi convalesc vaccin individu treatment base oxygen supplement support protocol due lack specif drug studi identifi three lead inhibitor aryl coumarin deriv tri naphthalen yl h chromen one nf hydroxyphenyl di naphthalen yl h chromen one nf hydroxyphenyl di naphthalen yl h chromen one nf show higher bind affin toward junction sar cov spike glycoprotein protein human angiotensin convert enzym ace receptor use molecular dock analysi identifi putat bind site potent inhibitor notabl molecular dynam md simul mm pbsa studi confirm inhibitor potenti abil bind spike proteinac protein complex minim energi two major concern adapt mutat spike protein ny dg display strong affin toward nf dock analysi addit vitro vivo studi requir confirm find develop inhibitor potenti drug sar cov
D000085962;D000086382
T067;T047;T126;T116
36,220,879
galectin bind protein stimul il express imped antibodi intervent sar cov suscept cell line covid global pandem affect popul past year consider research done better understand pathophysiolog diseas identifi new therapeut target especi sever case galectin gal receptor present surfac differ cell type name epitheli inflammatori cell describ sever marker covid activ gal bind protein gal bp direct link product pro inflammatori cytokin contribut cytokin storm cs observ sever covid patient show recombin fragment lectin bind region gal bp abl stimul express il colon lung epitheli cell line galactosid depend manner show induc il augment reduc anti gal bp monoclon antibodi data confirm extend prior find gal bp mediat il induct enlighten potenti antibodi mediat blockag prevent treatment cs sever diseas covid patient
D000086382;D000086402
T047;T067;T005
36,220,878
vitro test salt coat fabric potenti antivir agent reusabl face mask coronavirus diseas covid pandem wear face mask public space becam mandatori countri risk self contamin handl face mask one earliest concern mitig ad antivir coat mask present studi evalu antivir effect sodium chlorid deposit fabric suitabl manufactur reusabl cloth mask use techniqu adapt home environ test eight coat condit involv spray dip method three salt dilut influenza hn virus particl incub direct salt coat materi collect ad human airway epitheli cultur live virus replic epithelia quantifi time collect apic wash relat non coat materi salt deposit mgcm mark reduc viral replic howev even larger quantiti salt effect coat remain depend crystal size distribut turn depend coat techniqu find confirm suitabl salt coat antivir protect cloth mask also emphas particular attent paid coat protocol develop consum solut
D000086382;D000086402
T047;T067;T005
36,220,877
lysyl trna synthetas target urgent need tuberculosi drug tuberculosi major global caus mortal financi burden main low middl incom countri given signific ongo rise drug resist strain mycobacterium tuberculosi within clinic set urgent need develop new safe effect treatment develop drug like seri base fuse dihydropyrrolidino pyrimidin scaffold describ seri develop tuberculosi lysyl trna synthetas lysr cellular studi support mechan action ddd lead compound efficaci mous model acut chronic tuberculosi suitabl physicochem pharmacokinet properti vitro safeti profil support develop import preliminari analysi use clinic resist strain show pre exist clinic resist toward scaffold
D008250;D009169;D014376
T007;T047;T126;T116
36,220,875
gradient boost decis tree becom reliabl logist regress predict probabl diabet big data sought verifi reliabl machin learn ml develop diabet predict model util big data end compar reliabl gradient boost decis tree gbdt logist regress lr model use data obtain kokuho databas osaka prefectur japan develop model focus predictor health checkup data april decemb total elig particip studi predict model develop use light gradient boost machin lightgbm effect gbdt implement algorithm lr reliabl measur base expect calibr error ece negat log likelihood logloss reliabl diagram similar classif accuraci measur area curv auc analyz reliabl chang sampl size train among particip male femal newli diagnos diabet within year lightgbm lr achiev ece logloss auc sampl size analysi reliabl lightgbm becam higher lr sampl size increas formula see text thus confirm gbdt provid reliabl model lr develop diabet predict model use big data ml could potenti produc high reliabl diabet predict model help tool improv lifestyl prevent diabet
D000077558;D003920
T047;T170
36,220,873
stack ensembl machin learn model predict alpha antitrypsin defici associ liver diseas clinic outcom base uk biobank data alpha antitrypsin defici associ liver diseas aatd ld rare genet disord well recogn predict clinic outcom aatd ld defin patient like progress advanc liver diseas crucial better understand aatd ld progress promot time medic intervent aim develop tailor machin learn ml model predict diseas progress aatd ld analysi conduct stack ensembl learn model combin five differ ml algorithm predictor variabl use nest five fold cross valid repetit base uk biobank data perform model assess predict accuraci area receiv oper characterist auroc area precis recal curv auprc import predictor contribut evalu featur import permut method propos stack ensembl ml model show clinic meaning accuraci appear superior singl ml algorithm ensembl eg auroc aatd ld caus mortal liver relat death liver transplant caus mortal liver transplant respect work support use ml address unansw clinic question clinic meaning accuraci use real world data
D018070;D019896
T093;T047
36,220,871
novel assess fine motor function reveal earli hindlimb detect forelimb deficit experiment model al amyotroph later sclerosi al neurodegen disord associ loss cortic spinal motor neuron mns muscl degener kiernan et al lancet preclin set function test detect earli chang motor function rodent model al critic understand etiolog diseas treatment develop establish string pull paradigm detect forelimb hindlimb motor deficit sod mous model al earlier tradit motor perform task addit find indic earli loss forelimb hindlimb function correl cortic spinal mn loss respect task ecolog low cost effici non oner also requir littl anim handl reduc stress place anim long concern field sod mous display forelimb motor deficit give research complet pictur diseas provid evid sod model fact develop earli forelimb motor deficit due task abil assess fine motor function reconcil model various clinic present al taken togeth string pull paradigm may provid novel insight pathogenesi al offer nuanc evalu prospect treatment high translat potenti clinic
D000690
T047
36,220,870
methicillin resist staphylococcus aureus nosocomi infect distinct epidemiolog posit act marker overal hospit acquir infect trend ongo healthcar debat whether control hospit acquir infect hai methicillin resist staphylococcus aureus mrsa result lower global hai rate mrsa simpli replac anoth pathogen chang overal diseas burden surg drug resist hospit acquir pathogen covid pandem remain import issu use dataset million patient acut care facil across usa aid threshold model model nonlinear outbreak diseas show mrsa addit total burden hai distinct epidemiolog posit simpli replac microb caus hai critic mrsa reduc replac anoth pathogen rather lower overal hai burden analysi also show control mrsa benchmark well non aureus nosocomi infect hospit prevent result high relev healthcar epidemiologist polici maker assess impact mrsa hospit patient find stress major import mrsa uniqu caus nosocomi infect well pivot role biomark demonstr measur efficaci lack thereof organ infect control program
D000086382;D003428;D055624;D013203
T007;T047;T067
36,220,868
low temperatur argon plasma jet cascad electrod techniqu biolog applic studi design perform characterist low temperatur argon plasma jet cascad electrod techniqu apjc present apjc design base tip ring structur cascad ring effect plasma jet driven repetit high voltag microsecond puls apjc structur measur qualit local surfac temperatur detect system appli generat plasma jet biolog surfac measur character electr paramet obtain plasma jet electr thermal cold plasma regim simul electr field distribut nozzl also yield similar result experiment result final cascad electrod guid plasma column nozzl output plasma temperatur within four centimet nozzl output c result plasma jet studi atom emiss spectroscopi intens spectral line atmospher argon plasma jet spectra obtain final experiment result output
D058626
T104
36,220,867
integr multiom analys dorsal root ganglia diabet neuropath pain use proteom phospho proteom metabolom diabet peripher neuropathi dpn character spontan pain extrem incid dpn continu rise global diabet epidem howev remain lack safe effect analges control chronic pain condit dorsal root ganglia drg contain soma sensori neuron modul sensori signal transduct central nervous system studi aim gain deeper understand chang molecular pathway drg dpn patient chronic pain recent report transcriptom chang drg dpn expand upon result integr metabolom proteom phospho proteom analys compar molecular profil drg dpn donor drg control donor without diabet chronic pain analys identifi decreas select amino acid phospholipid metabolit drg dpn donor import cellular mainten addit analys reveal chang suggest extracellular matrix ecm remodel alter mrna process result reveal new insight chang molecular profil associ dpn
D059350;D003920;D003929;D009437
T047;T184
36,220,865
deterior liver function age disturb sequenti system therapi unresect hepatocellular carcinoma studi aim investig clinic characterist patient unresect hepatocellular carcinoma hcc elig sequenti system therapi evalu patient hcc underw system therapi overal surviv os month month month first line second line third line later therapi group respect multivari analysi reveal modifi albumin bilirubin albi grade macrovascular invas extrahepat spread discontinu due advers event ae sequenti therapi independ factor os end therapi albi score signific wors among patient discontinu due ae among without convers rate second line third line therapi among patient discontinu due ae signific lower among patient without vs p vs p respect decis tree analysi albi grade non advanc age select split variabl respect sequenti system therapi conclus sequenti therapi prolong os unresect hcc addit good hepat function non advanc age clinic elig characterist sequenti system therapi
D006528;D008113
T191
36,220,864
close loop stimul later cervic spinal cord upper limb ampute enabl sensori discrimin case studi modern myoelectr prosthet hand multipl independ control degre freedom requir constant visual attent use effect somatosensori feedback provid inform avail vision alon essenti fine motor control limb similar stimul nervous system potenti provid artifici somatosensori feedback reduc relianc visual cue effici oper prosthet devic shown previous epidur stimul later cervic spinal cord evok tactil sensat perceiv eman miss arm hand peopl upper limb amput case studi two subject upper limb amput use somatotop match tactil feedback discrimin object size complianc control prosthet hand less min practic day subject abl use artifici somatosensori feedback perform subset discrimin task success level well chanc subject consist adept determin object size accuraci chanc subject achiev higher accuraci level determin object complianc accuraci chanc subject discrimin object properti slight chanc level suggest task design stimul encod scheme import determin object properti could reliabl identifi observ suggest chang intens artifici somatosensori feedback provid via spinal cord stimul readili use infer inform object properti minim train
D000674;D001186;D066193
T101;T023;T074