source stringlengths 32 209 | text stringlengths 18 1.5k |
|---|---|
https://en.wikipedia.org/wiki/Samuel%20Isaac%20Weissman | Dr Samuel Isaac Weissman (June 25, 1912 – June 12, 2007) was an American chemist and professor best known for his work on the application of electron spin resonance (ESR) to chemistry.
Weissman was born in South Bend, Indiana in 1912. He completed a chemistry degree at the University of Chicago in 1933 and his doctorate from the same university in 1938.
Weissman was working on a project on fluorescent energy transfer, which later led to some rare-earth lasers, at the University of California at Berkeley when he was asked to join the Manhattan Project developing atomic weapons in 1943. He was among a group who asked unsuccessfully that the bomb not be dropped on civilian targets.
After his Los Alamos stint, Weissman went to the Washington University in St. Louis in 1946 becoming a full professor in 1955. At Washington University, Weissman worked with others developing the use of electron spin resonance. He was one of the first, probably in parallel with Clyde Hutchison, to measure the hyperfine splitting of the ESR line caused by the interaction with nuclear spins. This hyperfine splitting is the main source of the sensitivity of ESR to the chemical environment of the electron, and hence it underlies the broad applications of ESR in chemistry. Much of his work concerned the way this interaction term behaves as molecules tumble around in solution or undergo chemical reactions. He also investigated the special non-equilibrium ESR effects which are found as reactions take plac |
https://en.wikipedia.org/wiki/Post-silicon%20validation | Post-silicon validation and debug is the last step in the development of a semiconductor integrated circuit.
Pre-silicon process
During the pre-silicon process, engineers test devices in a virtual environment with sophisticated simulation, emulation, and formal verification tools. In contrast, post-silicon validation tests occur on actual devices running at-speed in commercial, real-world system boards using logic analyzer and assertion-based tools.
Reasoning
Large semiconductor companies spend millions creating new components; these are the "sunk costs" of design implementation. Consequently, it is imperative that the new chip function in full and perfect compliance to its specification, and be delivered to the market within tight consumer windows. Even a delay of a few weeks can cost tens of millions of dollars. Post-silicon validation is therefore one of the most highly leveraged steps in successful design implementation.
Validation
Chips comprising 500,000 logic elements are the silicon brains inside cell phones, MP3 players, computer printers and peripherals, digital television sets, medical imaging systems, components used in transportation safety and comfort, and even building management systems. Either because of their broad consumer proliferation, or because of their mission-critical application, the manufacturer must be absolutely certain that the device is thoroughly validated.
The best way to achieve high confidence is to leverage the pre-silicon verificat |
https://en.wikipedia.org/wiki/Adel%20El%20Hadi | Adel El Hadi (born 18 January 1980) is an Algerian former football player.
National team statistics
Honours
Top scorer of the Algerian league in 2003/2004 with 17 goals for USM Annaba
Top scorer of the Algerian second division in 2006/2007 with 19 goals for USM Annaba
Has 5 caps for the Algerian National Team
References
External links
1980 births
Living people
Algerian men's footballers
Algeria men's international footballers
Algerian Ligue Professionnelle 1 players
Algerian Ligue 2 players
Algeria men's under-23 international footballers
CA Batna players
CA Bordj Bou Arréridj players
CR Belouizdad players
ES Sétif players
JSM Béjaïa players
People from Biskra
USM Annaba players
US Biskra players
Competitors at the 2001 Mediterranean Games
Men's association football forwards
Mediterranean Games competitors for Algeria
21st-century Algerian people |
https://en.wikipedia.org/wiki/Samir%20Zazou | Samir Zazou (born March 24, 1980 in Sidi Bel Abbès) is an Algerian footballer who is currently playing as a defender for ASO Chlef in the Algerian Ligue Professionnelle 1.
National team statistics
Honours
Won the Algerian Ligue Professionnelle 1 three times:
Once with CR Belouizdad in 2001
Once with JS Kabylie in 2006
Once with ASO Chlef in 2011
Has 5 caps for the Algerian National Team
References
External links
Living people
Algerian men's footballers
Algeria men's international footballers
1980 births
JS Kabylie players
CR Belouizdad players
ASO Chlef players
Algerian Ligue Professionnelle 1 players
Algeria men's A' international footballers
USM Annaba players
2011 African Nations Championship players
USM Bel Abbès players
People from Sidi Bel Abbès
Competitors at the 2001 Mediterranean Games
Men's association football defenders
Mediterranean Games competitors for Algeria
21st-century Algerian people |
https://en.wikipedia.org/wiki/Vector-06C | Vector-06C () is a home computer with unique graphics capabilities that was designed and mass-produced in USSR in the late 1980s.
History
Vector-06C was created by Soviet engineers Donat Temirazov and Alexander Sokolov from Kishinev, Moldovan SSR. On 33rd National Radio Exhibition the design was honoured with the grand prize.
Shortly after that several factories started production of Vector-06C. In 1988 Vector was honoured a prize on
Exhibition of Achievements of the National Economy.
There were modifications adopting Zilog Z80 CPU or the unique Soviet KR580VM1 CPU. A commercial project called Vector Turbo+ with a Z80 CPU, clock frequency increased to 6 or 12 MHz, RAM sized up to 2 MiB and a variety of other improvements was in development. However, according to the InVector e-zine, a prototype of this system never left the work bench due to economical reasons.
Vector has gradually become less popular with the increasing flow of IBM PC-compatible computers on Soviet and then CIS markets. Presently Vector-06C enjoys loyal following of the few remaining fans.
Hardware
CPU: KR580VM80A (8080 clone), factory overclocked to 3 MHz (standard frequency was 2.5MHz);
Busses: 8-bit data bus, 16-bit address bus;
Memory: 64 KiB RAM, up to 32 KiB can be used as video memory; 2048 bytes of ROM (512 bytes in earlier models);
Video
Video system supports following modes:
256×256 pixels, 16 simultaneously displayed colours out of 256-colour palette
512×256 pixels, 4 simultaneous |
https://en.wikipedia.org/wiki/Zero%20field%20NMR | Zero- to ultralow-field (ZULF) NMR is the acquisition of nuclear magnetic resonance (NMR) spectra of chemicals with magnetically active nuclei (spins 1/2 and greater) in an environment carefully screened from magnetic fields (including from the Earth's field). ZULF NMR experiments typically involve the use of passive or active shielding to attenuate Earth’s magnetic field. This is in contrast to the majority of NMR experiments which are performed in high magnetic fields provided by superconducting magnets. In ZULF experiments the dominant interactions are nuclear spin-spin couplings, and the coupling between spins and the external magnetic field is a perturbation to this. There are a number of advantages to operating in this regime: magnetic-susceptibility-induced line broadening is attenuated which reduces inhomogeneous broadening of the spectral lines for samples in heterogeneous environments. Another advantage is that the low frequency signals readily pass through conductive materials such as metals due to the increased skin depth; this is not the case for high-field NMR for which the sample containers are usually made of glass, quartz or ceramic.
High-field NMR employs inductive detectors to pick up the radiofrequency signals, but this would be inefficient in ZULF NMR experiments since the signal frequencies are typically much lower (on the order of hertz to kilohertz). The development of highly sensitive magnetic sensors in the early 2000s including SQUIDs, magnetoresis |
https://en.wikipedia.org/wiki/Birdnest | Birdnest may refer to:
Bird nest - For birds
Birdnest wiring - Electronic interconnection used for prototyping and high frequency applications
Birdnest Records - Swedish punk record company |
https://en.wikipedia.org/wiki/Crystal%20Beach%20Cyclone | The Crystal Beach Cyclone was one of a 'Terrifying Triplet' of highly extreme and intense roller coasters designed and built by Harry G. Traver in the late 1920s. The Cyclone was located at the Crystal Beach Park in Ontario, Canada.
History
Three of these coasters (known as the 'Terrifying Triplets' of the Giant Cyclone Safety Coasters) were designed and built. The Crystal Beach 'Cyclone' and the Revere Beach 'Lightning' were both opened in 1927. The following year, the Schneck brothers, owners of Palisades Park in Fort Lee, NJ, contracted Traver to build a 'Cyclone' for the 1928 season. Of the three, the Crystal Beach version was the most famous and longest lasting, eventually being dismantled in September 1946 due to the high maintenance costs and falling revenues. Some of the wood and steel from the Cyclone was used by John Allen and Herbert Schmeck (both designers for the Philadelphia Toboggan Company) in the construction of the Crystal Beach Comet coaster in 1948.
Construction
Over 225 tonnes of metal were used in building the ride, which used a steel support structure instead of the more traditional wood. Having said this, it is still considered a "woodie", due to the construction of the track (300 X 25 millimetre wood laminants topped by a flat steel rail). Total length of wood used was about 6,100 metres - all British Columbia fir. At night, 1,000 small incandescent lamps lit the ride.
Ride layout
The layout consisted of a twisted arrangement of track with many |
https://en.wikipedia.org/wiki/Reductive%20dual%20pair | In the mathematical field of representation theory, a reductive dual pair is a pair of subgroups (G, G′) of the isometry group Sp(W) of a symplectic vector space W, such that G is the centralizer of G′ in Sp(W) and vice versa, and these groups act reductively on W. Somewhat more loosely, one speaks of a dual pair whenever two groups are the mutual centralizers in a larger group, which is frequently a general linear group. The concept was introduced by Roger Howe in . Its strong ties with Classical Invariant Theory are discussed in .
Examples
The full symplectic group G = Sp(W) and the two-element group G′, the center of Sp(W), form a reductive dual pair. The double centralizer property is clear from the way these groups were defined: the centralizer of the group G in G is its center, and the centralizer of the center of any group is the group itself. The group G′, consists of the identity transformation and its negative, and can be interpreted as the orthogonal group of a one-dimensional vector space. It emerges from the subsequent development of the theory that this pair is a first instance of a general family of dual pairs consisting of a symplectic group and an orthogonal group, which are known as type I irreducible reductive dual pairs.
Let X be an n-dimensional vector space, Y be its dual, and W be the direct sum of X and Y. Then W can be made into a symplectic vector space in a natural way, so that (X, Y) is its lagrangian polarization. The group G is the general li |
https://en.wikipedia.org/wiki/Bellanca%2077-140 |
The Bellanca 77-140 Bomber was a bomber aircraft built in small numbers in the United States in the 1930s. It was a derivative of Bellanca's successful Aircruiser civil transport in which the Aircruiser's single, nose-mounted engine was replaced by twin engines on the upper wing. The United States military were not interested in the type, but the Colombian Air Force bought a small number, including a float-equipped version dubbed the 77-320 Junior. This version also differed from the landplane in having a fully enclosed nose turret in place of the open turret of the 77-140.
Specifications (77-140)
Users
Colombian Air Force
See also
References
aerofiles.com
Fuerza Aérea Colombiana
77-140
1930s United States bomber aircraft
High-wing aircraft
Aircraft first flown in 1934
Twin piston-engined tractor aircraft
Flugzeug Fibel |
https://en.wikipedia.org/wiki/4-PPBP | 4-PPBP is a neuroprotective cyclic amine which binds to sigma receptors.
4-PPBP decreases neuronal nitric oxide synthase (nNOS) activity and ischemia-evoked nitric oxide (NO) production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+ dysregulation. 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB). Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.
See also
3-PPP
References
4-Phenylpiperidines
Sigma agonists |
https://en.wikipedia.org/wiki/Cutamesine | Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.
Structure
The molecular formula for cutamesine is C23H32N2O2. This particular agonist is a piperazine, meaning that its core functional group is a six-membered heterocycle with two oppositely-placed nitrogen atoms. Two phenalkyl groups act as substituents for the two nitrogen atoms. The phenethyl group has methoxy groups on the 3 and 4 locations of the aromatic ring, while the phenpropyl group has no additional functional groups attached.
Affinity
Causes of Affinity
The 3,4-methoxy groups located on the phenethyl group play an important role in σ receptor binding affinity, with alterations made to these groups leading to changes in affinity to σ1. Replacement side groups that possess the most steric bulk have the lowest binding affinity for the σ1 receptor. The nitrogen atoms in the molecule play a central role in its affinity, as removal of these nitrogen atoms results in a lack of affinity to σ1. N(b) - the nitrogen in the piperazine attached to the longest substituent - plays a much greater role in |
https://en.wikipedia.org/wiki/1-Cyclohexylpiperazine | 1-Cyclohexylpiperazine is a derivative of piperazine, and a precursor for PB-28.
1-Piperazinyl compounds
Cyclohexyl compounds |
https://en.wikipedia.org/wiki/Gluteal%20aponeurosis | The gluteal aponeurosis is a fibrous membrane, from the fascia lata, that lies between the iliac crest and the superior border of the gluteus maximus. A part of the gluteus medius arises from this membrane.
Pelvis |
https://en.wikipedia.org/wiki/Halbert%20L.%20Dunn | Halbert L. Dunn, M.D. (1896–1975) was the leading figure in establishing a national vital statistics system in the United States and is known as the "father of the wellness movement".
Early life
Born in New Paris, Ohio, he attended the University of Minnesota where he earned his M.D. in 1922 and his Ph.D. in 1923. He served as an assistant in medicine at Presbyterian Hospital of New York City 1923-1924 and as fellow in medicine at the Mayo Clinic in Rochester, Minnesota (1924–1925).
Work in statistics
In 1929, he was the first biostatistician hired by the Mayo Clinic and established its computer coding system for deriving medical statistics. He was Chief of the National Office of Vital Statistics from 1935 through 1960, first as part of the Bureau of the Census and later under the Department of Health, Education and Welfare, where it eventually became the National Center for Health Statistics in 1960. In his final year with the U.S. Public Health Service he was Assistant Surgeon General for aging.
He was one of the founders of the National Association for Public Health Statistics and Information Systems (NAPHSIS) and of the Inter-American Statistics Institute (IASI). He was Secretary General of the IASI from 1941 to 1952. The Halbert L. Dunn Award, named in his honor, has been presented since 1981 by NAPHSIS in recognition of outstanding and lasting contributions to the field of vital and health statistics.
Wellness
Dunn is known as the "father" of the wellness movement. |
https://en.wikipedia.org/wiki/Genome-wide%20association%20study | In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. GWA studies typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major human diseases, but can equally be applied to any other genetic variants and any other organisms.
When applied to human data, GWA studies compare the DNA of participants having varying phenotypes for a particular trait or disease. These participants may be people with a disease (cases) and similar people without the disease (controls), or they may be people with different phenotypes for a particular trait, for example blood pressure. This approach is known as phenotype-first, in which the participants are classified first by their clinical manifestation(s), as opposed to genotype-first. Each person gives a sample of DNA, from which millions of genetic variants are read using SNP arrays. If there is significant statistical evidence that one type of the variant (one allele) is more frequent in people with the disease, the variant is said to be associated with the disease. The associated SNPs are then considered to mark a region of the human genome that may influence the risk of disease.
GWA studies investigate the entire genome, in contrast to methods that specifically test a small number of pre-specified genetic regions. Hence, GWAS is a non-candidate-driven |
https://en.wikipedia.org/wiki/Transpeptidase | Transpeptidase may refer to:
DD-transpeptidase, a bacterial enzyme that cross-links the peptidoglycan chains to form rigid cell walls
Gamma-glutamyl transpeptidase, a liver enzyme
D-glutamyl transpeptidase
A protein-sorting transpeptidase (e.g. sortase), that cleaves a C-terminal sorting signal from its target protein(s) and then covalently attaches the remainder to the cell surface. |
https://en.wikipedia.org/wiki/Krantz | Krantz is a surname.
Geographical distribution
As of 2014, 59.1% of all known bearers of the surname Krantz were residents of the United States (frequency 1:40,458), 22.7% of Sweden (1:2,867), 4.2% of France (1:105,067), 3.9% of Germany (1:136,212), 1.7% of Canada (1:142,077), 1.4% of Israel (1:39,650) and 1.4% of South Africa (1:260,746).
In Sweden, the frequency of the surname was higher than national average (1:2,867) in the following regions:
1. Gävleborg County (1:1,245)
2. Jönköping County (1:1,269)
3. Västra Götaland County (1:1,980)
4. Kalmar County (1:2,038)
5. Kronoberg County (1:2,175)
6. Halland County (1:2,216)
7. Uppsala County (1:2,776)
People
Albert Krantz (1448-1517), German historian
Gordon Krantz, Canadian politician
Grover Krantz (1931-2002), American Bigfoot researcher
Jacob Krantz (1900-1977), American actor better known as Ricardo Cortez
Judith Krantz (1928–2019), American author and journalist
Kermit E Krantz, American physician and inventor
Morgan Krantz, American actor and writer
Steve Krantz (1923–2007), American film producer and writer
Steven G. Krantz, American mathematician
Tobias Krantz (born 1971), Swedish politician
Wayne Krantz, American musician
Landen Krantz, Professional Football Player
Ross Krantz, (1933-2017), Sound Engineer and Projectionist
Stefanie Krantz, (1972 - ) Ecologist and Climate Change Planner
See also
Kranz (surname)
Cranz (disambiguation)
References
German-language surnames
Surnames of Jewish |
https://en.wikipedia.org/wiki/Polymerase%20cycling%20assembly | Polymerase cycling assembly (or PCA, also known as Assembly PCR) is a method for the assembly of large DNA oligonucleotides from shorter fragments. The process uses the same technology as PCR, but takes advantage of DNA hybridization and annealing as well as DNA polymerase to amplify a complete sequence of DNA in a precise order based on the single stranded oligonucleotides used in the process. It thus allows for the production of synthetic genes and even entire synthetic genomes.
PCA principles
Much like how primers are designed such that there is a forward primer and a reverse primer capable of allowing DNA polymerase to fill the entire template sequence, PCA uses the same technology but with multiple oligonucleotides. While in PCR the customary size of oligonucleotides used is 18 base pairs, in PCA lengths of up to 50 are used to ensure uniqueness and correct hybridization.
Each oligonucleotide is designed to be either part of the top or bottom strand of the target sequence. As well as the basic requirement of having to be able to tile the entire target sequence, these oligonucleotides must also have the usual properties of similar melting temperatures, hairpin free, and not too GC rich to avoid the same complications as PCR.
During the polymerase cycles, the oligonucleotides anneal to complementary fragments and then are filled in by polymerase. Each cycle thus increases the length of various fragments randomly depending on which oligonucleotides find each other. It |
https://en.wikipedia.org/wiki/Stefan%27s%20formula | In thermodynamics, Stefan's formula says that the specific surface energy at a given interface is determined by the respective enthalpy difference .
where σ is the specific surface energy, NA is the Avogadro constant, is a steric dimensionless coefficient, and Vm is the molar volume.
References
Thermodynamic equations
Chemical thermodynamics |
https://en.wikipedia.org/wiki/DMWD | DMWD may refer to:
Department of Miscellaneous Weapons Development, a British Admiralty department during World War II
DMWD (gene), a human gene protein which encodes dystrophia myotonica WD repeat-containing protein |
https://en.wikipedia.org/wiki/Noncentral%20hypergeometric%20distributions | In statistics, the hypergeometric distribution is the discrete probability distribution generated by picking colored balls at random from an urn without replacement.
Various generalizations to this distribution exist for cases where the picking of colored balls is biased so that balls of one color are more likely to be picked than balls of another color.
This can be illustrated by the following example. Assume that an opinion poll is conducted by calling random telephone numbers. Unemployed people are more likely to be home and answer the phone than employed people are. Therefore, unemployed respondents are likely to be over-represented in the sample. The probability distribution of employed versus unemployed respondents in a sample of n respondents can be described as a noncentral hypergeometric distribution.
The description of biased urn models is complicated by the fact that there is more than one noncentral hypergeometric distribution. Which distribution one gets depends on whether items (e.g., colored balls) are sampled one by one in a manner in which there is competition between the items or they are sampled independently of one another. The name noncentral hypergeometric distribution has been used for both of these cases. The use of the same name for two different distributions came about because they were studied by two different groups of scientists with hardly any contact with each other.
Agner Fog (2007, 2008) suggested that the best way to avoid confusion is t |
https://en.wikipedia.org/wiki/Particle-size%20distribution | In granulometry, the particle-size distribution (PSD) of a powder, or granular material, or particles dispersed in fluid, is a list of values or a mathematical function that defines the relative amount, typically by mass, of particles present according to size. Significant energy is usually required to disintegrate soil, etc. particles into the PSD that is then called a grain size distribution.
Significance
The PSD of a material can be important in understanding its physical and chemical properties. It affects the strength and load-bearing properties of rocks and soils. It affects the reactivity of solids participating in chemical reactions, and needs to be tightly controlled in many industrial products such as the manufacture of printer toner, cosmetics, and pharmaceutical products.
Significance in the collection of particulate matter
Particle size distribution can greatly affect the efficiency of any collection device.
Settling chambers will normally only collect very large particles, those that can be separated using sieve trays.
Centrifugal collectors will normally collect particles down to about 20 μm. Higher efficiency models can collect particles down to 10 μm.
Fabric filters are one of the most efficient and cost effective types of dust collectors available and can achieve a collection efficiency of more than 99% for very fine particles.
Wet scrubbers that use liquid are commonly known as wet scrubbers. In these systems, the scrubbing liquid (usually water) com |
https://en.wikipedia.org/wiki/Douglas%20Ring | Douglas Ring may refer to:
Douglas H. Ring (1907–2000), American engineer, co-inventor of the cell phone
Doug Ring (Douglas Thomas Ring, 1918–2003), Australian cricketer |
https://en.wikipedia.org/wiki/Stearyl%20palmityl%20tartrate | Stearyl palmityl tartrate is a derivative of tartaric acid used as an emulsifier. It is produced by esterification of tartaric acid with commercial grade stearyl alcohol, which generally consists of a mixture of the fatty alcohols stearyl and palmityl alcohol. Stearyl palmityl tartrate consists mainly of diesters, with minor amounts of monoester and of unchanged starting materials.
Use
Stearyl palmityl tartrate is used as emulsifier under the E number E 483. The Food and Agriculture Organization of the United Nations sets limits of use at 4 g/kg for bakery wares and 5 g/kg for dessert products.
Law
Use of stearyl palmityl tartrate is prohibited in Australia.
References
Food additives
Tartrate esters
E-number additives |
https://en.wikipedia.org/wiki/Siegel%27s%20lemma | In mathematics, specifically in transcendental number theory and Diophantine approximation, Siegel's lemma refers to bounds on the solutions of linear equations obtained by the construction of auxiliary functions. The existence of these polynomials was proven by Axel Thue; Thue's proof used Dirichlet's box principle. Carl Ludwig Siegel published his lemma in 1929. It is a pure existence theorem for a system of linear equations.
Siegel's lemma has been refined in recent years to produce sharper bounds on the estimates given by the lemma.
Statement
Suppose we are given a system of M linear equations in N unknowns such that N > M, say
where the coefficients are rational integers, not all 0, and bounded by B. The system then has a solution
with the Xs all rational integers, not all 0, and bounded by
gave the following sharper bound for the X'''s:
where D is the greatest common divisor of the M × M minors of the matrix A, and AT is its transpose. Their proof involved replacing the pigeonhole principle by techniques from the geometry of numbers.
See also
Diophantine approximation
References
Wolfgang M. Schmidt. Diophantine approximation. Lecture Notes in Mathematics 785. Springer. (1980 [1996 with minor corrections]) (Pages 125-128 and 283-285)
Wolfgang M. Schmidt. "Chapter I: Siegel's Lemma and Heights" (pages 1–33). Diophantine approximations and Diophantine equations'', Lecture Notes in Mathematics, Springer Verlag 2000.
Lemmas
Diophantine approximation
Diophantine |
https://en.wikipedia.org/wiki/Glue%20%28disambiguation%29 | Glue is any fluid adhesive.
Glue or GLUE may also refer to:
In arts and entertainment
Glue (film), a 2006 Argentine film written and directed by Alexis Dos Santos
Glue (novel), a novel by Scottish writer Irvine Welsh
Glue (TV series), a 2014 British television drama written by Jack Thorne
"Glue" (New Girl)
"Glue" (Weeds)
In music
Glue (Eugene + the Lizards album), 2009
Glue (Boston Manor album), 2020
"Glue", a song from the 2010 Ten (Gabriella Cilmi album)
"Glue", a song by Bicep from their 2017 Bicep (album)
"Glue", a song by Breathe Carolina from their 2017 EP Coma
Glue, a hip-hop trio fronted by Adeem (rapper)
"Glue" a 2023 song by Beabadoobee
In electronics and computing
Glue logic, circuitry to interface between off-the-shelf integrated circuits
Glue records, records used in the Domain Name System (DNS)
General Language Understanding Evaluation, a benchmark in Natural Language Understanding
Grid Laboratory Uniform Environment, a technology-agnostic information model for a uniform representation of Grid resources
Software
glue (software), a data-visualization package
Glue code, code that serves to "glue together" otherwise incompatible code
Glue language, a programming language used for connecting software components together
webMethods Glue, a platform that provides web services/SOAP capabilities to existing Java and C/C++ applications
Other uses
GLUE (uncertainty assessment), a method to quantify the uncertainty of model predictions
Glue sem |
https://en.wikipedia.org/wiki/Tureia%20Airport | Tureia Airport is an airport on Tureia in French Polynesia .
Tureia Airport was inaugurated in 1985.
Airlines and destinations
Passenger
No scheduled flights as of May 2019.
Statistics
References
Airports in French Polynesia |
https://en.wikipedia.org/wiki/Levin%20%28surname%29 | Levin (original Russian: Левин) is a surname with several word origins. It is a common Ashkenazi Jewish surname (Levine/Levin/Levi).
In the Jewish variant (a form of Levy) it is derivative of one of the 12 Jewish biblical tribes, the tribe of Levi, whose descendants the Levites had distinctive duties in the Temple period.
In the Russian variant, Levin comes from lev (лев) which means lion in Russian. It can also be pronounced Lyovin (Лёвин) which is a patronymic form of Лёва.
Other variations include Lavin, Lavine, Le Neve, Levene, Levi, Levina, Levine, Levitt, Levy, Lewin, Lieven, Levins and Levinson.
People with the name "Levin" (and Russian feminine variant Levina) include:
People
A–I
A. Leo Levin (1919–2015), American law professor at the University of Pennsylvania Law School
Adam K. Levin, former director of the New Jersey Division of Consumer Affairs and businessman in consumer credit-related businesses
Adam Levin, fiction author
Alan Levin (business), American businessmen, CFO of drug maker Pfizer
Alan Levin (filmmaker) (1926–2006), American filmmaker and journalist
Alan Levin (Internet governance), South African computer scientist and Internet activist
Aleksandr Mitrofanovich Levin (1871–1929), Russian chess player
Alter Levin (1883–1933), Hebrew writer and poet
Andy Levin (born 1960), US Democratic Representative from Michigan; son of Sander and nephew of Carl
Arnold Levin, New Yorker cartoonist
Bengt Levin (1958–2020), Swedish orienteering competito |
https://en.wikipedia.org/wiki/List%20of%20urban%20areas%20in%20the%20Nordic%20countries | This is a list of urban areas in the Nordic countries by population. Urban areas in the Nordic countries are measured at national level, independently by each country's statistical office. Statistics Sweden uses the term tätort (urban settlement), Statistics Finland also uses tätort in Swedish and taajama in Finnish, Statistics Denmark uses byområde (city), while Statistics Norway uses tettsted (urban settlement).
A common statistical definition between the Nordic countries was agreed in 1960, which defines an urban area as a contiguous built-up area with a population of at least 200 and where the maximum distance between dwellings is 200 metres, excluding roads, car parks, parks, sports grounds and cemeteries - regardless of the boundaries of the municipality, district or county. Despite the common definition, the different statistical offices have different approaches to carrying out these measurements, resulting in slight differences between countries.
The Nordic definition is unique to these countries and should not be confused with international concepts of metropolitan area or urban areas in general. In 2010, Finland (stat.fi) changed its definition. This means that, according to official statistics, the land area covered by urban areas is three times larger in Finland than in Norway, although the total urban population is about the same (ssb.no). It also means that the population of a Danish 'byområder' is usually less than half the population of the 'functional urba |
https://en.wikipedia.org/wiki/Signature-tagged%20mutagenesis | Signature-tagged mutagenesis (STM) is a genetic technique used to study gene function. Recent advances in genome sequencing have allowed us to catalogue a large variety of organisms' genomes, but the function of the genes they contain is still largely unknown. Using STM, the function of the product of a particular gene can be inferred by disabling it and observing the effect on the organism. The original and most common use of STM is to discover which genes in a pathogen are involved in virulence in its host, to aid the development of new medical therapies/drugs.
Basic premise
The gene in question is inactivated by insertional mutation; a transposon is used which inserts itself into the gene sequence. When that gene is transcribed and translated into a protein, the insertion of the transposon affects the protein structure and (in theory) prevents it from functioning. In STM, mutants are created by random transposon insertion and each transposon contains a different 'tag' sequence that uniquely identifies it. If an insertional mutant bacterium exhibits a phenotype of interest, such as susceptibility to an antibiotic it was previously resistant to, its genome can be sequenced and searched (using a computer) for any of the tags used in the experiment. When a tag is located, the gene that it disrupts is also thus located (it will reside somewhere between a start and stop codon which mark the boundaries of the gene).
STM can be used to discover which genes are critical to a path |
https://en.wikipedia.org/wiki/Crystal%20Gayle%20in%20Concert | Crystal Gayle in Concert is an hour long live recording of Crystal Gayle's 1982 HBO TV special, filmed at Canada's Hamilton Place Theatre. Released numerous times on VHS video, White Star Records also issued it on DVD in 2005. Gayle was most famous in the 1970s and 1980s, for her string of Country-Pop crossover songs like "Don't It Make My Brown Eyes Blue" and "Half the Way". In this concert she sings live versions of some of her biggest hits, as well as some otherwise unreleased songs.
Track listing
Introduction
"Gone at Last"
Early Hits Medley:
"Wrong Road Again", "Somebody Loves You", "I'll Get Over You"
"Why Have You Left the One You Left Me For"
"When I Dream"
"What a Little Moonlight Can Do"
Standards Medley:
"Lover Man", "Since I Fell for You", "Mean to Me"
"You Never Gave Up on Me"
"Same Old Story (Same Old Song)"
"Talking in Your Sleep"
"Ready for the Times to Get Better"
"True Love"
"Our Love Is on the Faultline"
"Don't It Make My Brown Eyes Blue"
"Half the Way"
"He Is Beautiful to Me"
"Rocky Top"
Credits
Crystal Gayle albums
2005 live albums
2005 video albums
Live video albums |
https://en.wikipedia.org/wiki/Live%21%20An%20Evening%20with%20Crystal%20Gayle | Live! An Evening With Crystal Gayle is a recording of a 2005 concert by Crystal Gayle at the Renaissance Center in Dickson, Tennessee. Originally released in a package containing a DVD and an edited CD, it was Gayle's first official live album and includes some of her biggest hits of the 1970s and 1980s, as well as several otherwise unreleased songs. It also includes Gayle singing some songs by her sister, Country music singer Loretta Lynn, like "Coal Miner's Daughter" (performed with her sister Peggy Sue). The DVD has various extra features, including an interview with Gayle and a photo gallery.
It was released on August 29, 2006 on Cleopatra Records.
The DVD has since been reissued by numerous different labels and though featuring identical content, has confusingly been given different titles, e.g. Live in Tennessee, Don't It Make My Brown Eyes Blue, Crystal Gayle Live and Crystal Gayle: Live in Concert (not to be confused with Crystal Gayle in Concert).
Track listing
"Everybody's Reaching Out for Someone"
"Green Door"
"Half the Way"
"Wrong Road Again"
"Somebody Loves You"
"Why Have You Left the One You Left Me For"
"Talking in Your Sleep"
"You Don't Even Know My Name"
"Old Songs" (with Jay Patten)
"Coal Miner's Daughter" (with Peggy Sue)
"Blue Moon of Kentucky" (with Peggy Sue)
"Ready for the Times to Get Better"
"Midnight in the Desert"
"More Money" (with Peggy Sue)
"Don't Come Home A' Drinkin' (With Lovin' on Your Mind)" (with Peggy Sue)
"That's What I Like About the |
https://en.wikipedia.org/wiki/Bohemian%20glass | Bohemian glass (), also referred to as Bohemia crystal (Český křišťál), is glass produced in the regions of Bohemia and Silesia, now parts of the Czech Republic. It has a centuries long history of being internationally recognised for its high quality, craftsmanship, beauty and often innovative designs. Hand-cut, engraved, blown and painted decorative glassware ranging from champagne flutes to enormous chandeliers, ornaments, figurines and other glass items are among the best known Czech exports and immensely popular as tourist souvenirs. The Czech Republic is home to numerous glass studios and schools attended by local and foreign students.
The oldest archaeological excavations of glass-making sites in the region date to around 1250 and are located in the Lusatian Mountains of Northern Bohemia. Other notable Czech sites of glass-making throughout the ages are Skalice (), Jablonec nad Nisou, Železný Brod, Poděbrady, Karlovy Vary, Kamenický Šenov () and Nový Bor (). Several of these towns have their own glass museums with many items dating to around 1600. Jablonec nad Nisou in particular is famous for the local tradition of manufacturing glass costume jewellery. Its long history is documented by large collections in the Museum of Glass and Jewellery in Jablonec nad Nisou.
Among the most famous Czech glass producers are: Moser (considered the most luxurious Czech brand), Rückl (the glass from them is owned, for example, by the British Queen Elizabeth II), and Crystalex (the la |
https://en.wikipedia.org/wiki/Expo%3A%20Magic%20of%20the%20White%20City | Expo: Magic of the White City is a 2005 American direct-to-video historical documentary film directed and produced by Mark Bussler, and narrated by Gene Wilder. The documentary tells the story of Chicago's World's Columbian Exposition in 1893.
Synopsis
It begins by explaining Frederick Law Olmsted's planning of the fair and the architecture by Daniel Burnham. It also details exhibits by many people, including George Westinghouse, Nikola Tesla and Thomas Edison.
In addition to detailing the fair itself, the documentary also describes the Midway Plaisance. Features of the Midway included bellydancing, side-shows, saloons, and a large Ferris wheel. Finally Expo: Magic of the White City discusses the aftermath of the fair and the legacy it left.
Cast
Gene Wilder as the Narrator
Release
It was released to DVD on September 13, 2005. Janson Media later acquired the copyright to the film in 2010.
DVD Special features
Commentary tracks by Mark Bussler, Brian Connelly and David Cope (World's Fair Historian)
Featurettes ("Making the Fair", "Art of the Fair", "Storyboards of the Fair", "Pictures of the Fair")
Deleted scenes
External links
Official Page
Official Trailer
Synopsis, information and reviews on Rotten Tomatoes
2005 films
2005 documentary films
2005 independent films
American documentary films
Documentary films about architecture
Documentary films about technology
World's Columbian Exposition
Documentary films about United States history
Direct-to-video documentary |
https://en.wikipedia.org/wiki/Joseki%20%28disambiguation%29 | Joseki is a sequence of standard moves in the game of Go.
Joseki may also refer to:
a sequence of standard moves in Shogi
JOSEKI, a pair of encryption algorithms used by the National Security Agency |
https://en.wikipedia.org/wiki/Wellcome%20Genome%20Campus | The Wellcome Genome Campus is a scientific research campus built in the grounds of Hinxton Hall, Hinxton in Cambridgeshire, England.
Campus
The Campus is home to some institutes and organisations in genomics and computational biology. The Campus is part of the Wellcome Trust, a global charitable foundation that exists to improve health, and houses the Wellcome Sanger Institute, the European Bioinformatics Institute (EBI), the bioinformatics outstation of the European Molecular Biology Laboratory (EMBL), and a number of biotech companies whose UK offices are located in the BioData Innovation Centre acting as an incubator for businesses of all sizes. Today, the Campus is a globally significant hub for scientific, business, educational and cultural activities for genomic and biodata sciences.
Over the next 15 years, there are significant plans to grow the Campus, extending its facilities to expand its community of scientific talent and business leaders with aligned interests.
Campus Facilities
As the leading hub of genomic science in Europe, the campus provides a range of facilities and services to support academic research, and businesses that operate in the genomics and biodata market. Its facilities include:
350+ seminars, lectures and training courses a year (free and paid for) to help educate staff and keep their skills current.
A state-of-the-art conference centre that attracts thousands of visitors every year.
Connecting Science is a group of experts who help the |
https://en.wikipedia.org/wiki/PEST%20sequence | A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S) and threonine (T). It is associated with proteins that have a short intracellular half-life, so might act as a signal peptide for protein degradation. This may be mediated via the proteasome or calpain.
References
Peptide sequences
Proteins
Post-translational modification |
https://en.wikipedia.org/wiki/Bloch%27s%20theorem%20%28complex%20variables%29 | In complex analysis, a branch of mathematics, Bloch's theorem describes the behaviour of holomorphic functions defined on the unit disk. It gives a lower bound on the size of a disk in which an inverse to a holomorphic function exists. It is named after André Bloch.
Statement
Let f be a holomorphic function in the unit disk |z| ≤ 1 for which
Bloch's Theorem states that there is a disk S ⊂ D on which f is biholomorphic and f(S) contains a disk with radius 1/72.
Landau's theorem
If f is a holomorphic function in the unit disk with the property |f′(0)| = 1, then let Lf be the radius of the largest disk contained in the image of f.
Landau's theorem states that there is a constant L defined as the infimum of Lf over all such functions f, and that L is greater than Bloch's constant L ≥ B.
This theorem is named after Edmund Landau.
Valiron's theorem
Bloch's theorem was inspired by the following theorem of Georges Valiron:
Theorem. If f is a non-constant entire function then there exist disks D of arbitrarily large radius and analytic functions φ in D such that f(φ(z)) = z for z in D.
Bloch's theorem corresponds to Valiron's theorem via the so-called Bloch's Principle.
Proof
Landau's theorem
We first prove the case when f(0) = 0, f′(0) = 1, and |f′(z)| ≤ 2 in the unit disk.
By Cauchy's integral formula, we have a bound
where γ is the counterclockwise circle of radius r around z, and 0 < r < 1 − |z|.
By Taylor's theorem, for each z in the unit disk, there exists 0 ≤ t ≤ |
https://en.wikipedia.org/wiki/Growth%20factor%20receptor | A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell to grow and/or divide.
These receptors may use the JAK/STAT, MAP kinase, and PI3 kinase pathways.
A majority of growth factor receptors consists of receptor tyrosine kinases (RTKs). There are 3 dominant receptor types that are exclusive to research : the epidermal growth factor receptor, the neurotrophin receptor, and the insulin receptors. All growth factor receptors are membrane bound and composed of 3 general protein domains: extracellular, transmembrane, and cytoplasmic. The extracellular domain region is where a ligand may bind, usually with very high specificity. In RTKs, the binding of a ligand to the extracellular ligand binding site leads to the autophosphorylation of tyrosine residues in the intracellular domain. These phosphorylations allow for other intracellular proteins to bind to with the phosphotyrosine-binding domain which results in a series of physiological responses within the cell.
Medical Relevance
Research in today’s society focus on growth factor receptors in order to pinpoint cancer treatment. Epidermal growth factor receptors are involved heavily with oncogene activity. Once growth factors bind to their recept |
https://en.wikipedia.org/wiki/At%20the%20Movies | At the Movies may refer to:
Television
At the Movies (1982 TV program), an American program, originally known as At the Movies with Gene Siskel and Roger Ebert
At the Movies (1986 TV program), a successor/competitor program (1986–2010) to the original, which was also known as Siskel & Ebert & the Movies
Ebert Presents: At the Movies, a successor program (2011)
At the Movies (Australian TV program), an Australian program (2004–2014) with a similar format to the American program
At the Movies, an episode segment of Rugrats
At the Movies, an episode of Beavis and Butt-head
Music
At the Movies (Creedence Clearwater Revival album), 1985
At the Movies (Mint 400 Records album), 2018; see
At the Movies (Stanley Clarke album), 1995
At the Movies (Richard & Adam album), 2014
At the Movies (Gary Williams album), 2017
At the Movies, an album by Sting
At the Movies (Dave Koz album), 2007
"At the Movies", a song by Bad Brains from Rock for Light
Van Morrison at the Movies – Soundtrack Hits, a compilation album by Van Morrison
See also |
https://en.wikipedia.org/wiki/Activin%20receptor | An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain.
Types include:
Activin type 1 receptors
Activin type 2 receptors
Human proteins containing this domain
ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; BMPR1A; BMPR1B;
BMPR2; TGFBR1;
References
External links
GS domain
TS domain
S/T domain
Single-pass transmembrane proteins |
https://en.wikipedia.org/wiki/Anti-M%C3%BCllerian%20hormone%20receptor | Anti-Müllerian hormone receptor is a receptor for the anti-Müllerian hormone. Furthermore, anti-Mullerian hormone receptor type 2 is a protein in humans that is encoded by the AMHR2 gene.
Function
Both men and women have this gene. AMHR2 is a Type 2 receptor that binds AMH (Anti-mullerian hormone). This hormone is responsible for Mullerian Duct regression in vertebrates once the SRY gene has been expressed. Some animals such as jawless fish do not express either AMH or AMHR2. High circulating AMH continues on after testis development and is secreted from the Sertoli Cells. It has been reported that the loss of function of the AMHR2 gene results in 50% of XY animals to reverse sex to females and also leads to hyperproliferation of mitotically active germ cells, which leads to the sex reversal. AMH binding to the AMHR2 in mammals causes regression of the oviducts, uterus, and upper 2/3 of the vagina. A syndrome called "Persistent Mullerian Duct Syndrome" (PMDS) can occur in human males and results in the uterus, vagina, and uterus being present in virilized male. PMDS can be caused by a genetic mutation of deletions, or missenses, and these males often have undescended testes or cryptorchidism, where one testis fails to descend outside of the body cavity. The majority of these patients will be infertile. In females that are homozygous for the mutation, no abnormalities have been observed. However, heterozygous females have been observed to reach menopause sooner and display |
https://en.wikipedia.org/wiki/Property%20derivative | A property derivative is a financial derivative whose value is derived from the value of an underlying real estate asset. In practice, because individual real estate assets fall victim to market inefficiencies and are hard to accurately price, property derivative contracts are typically written based on a real estate property index. In turn, the real estate property index attempts to aggregate real estate market information to provide a more accurate representation of underlying real estate asset performance. Trading or taking positions in property derivatives is also known as synthetic real estate.
Property derivatives usually take the form of a total return swap, forward contract, futures, or can adopt a funded format where the property derivative is embedded into a bond or note structure. Under the total return swap or forward contract the parties will usually take contrary positions on the price movements of a property index. See Exotic derivative.
The only index used for writing property derivative contracts in the UK are the various property indices published by the Investment Property Databank (IPD) now owned by MSCI. The IPD Annual Index covers approximately 12,000 directly held UK property investments, market revalued in December 2015 at just under £202 billion equivalent to 49% of the UK investment market. IPD indices have also been used in a number of other countries such as Australia, France, Germany, Italy, Japan and Switzerland as the basis for commercial |
https://en.wikipedia.org/wiki/ACVRL1 | Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene.
ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1.
Function
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia (HHT) type 2, also known as Rendu-Osler-Weber syndrome 2.
Pathology
Germline mutations of ACVRL1 are associated with:
hereditary hemorrhagic telangiectasia type 2 (Rendu-Osler-Weber syndrome 2)
Pulmonary arteriovenous malformations
Somatic mosaicism in ACVRL1 are associated with severe pulmonary arterial hypertension.
ACVRL1 directly interacts with low-density lipoprotein (LDL), which implies that it might initiate the early phases of atherosclerosis.
Abnormal activity of ACVRL1 has been found to be closely associated with idiopathic pulmonary arterial hypertension.
As a drug target
Dalantercept is an experimental ALK1 inhibitor.
Closely/family rela |
https://en.wikipedia.org/wiki/Latent%20TGF-beta%20binding%20protein | The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.
LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.
Genes
References
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Latent-transforming growth factor beta-binding protein 1 |
https://en.wikipedia.org/wiki/Gremlin%20%28protein%29 | Gremlin is an inhibitor in the TGF beta signaling pathway. It primarily inhibits bone morphogenesis and is implicated in disorders of increased bone formation and several cancers.
Structure
Gremlin1, previously known as Drm, is a highly conserved 20.7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Gremlin1 was first identified in differential screening as a transcriptional down-regulated gene in v-mos-transformed rat embryonic fibroblasts.
Function
Gremlin1 (Grem1) is known for its antagonistic interaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway. Grem1 inhibits predominantly BMP2 and BMP4 in limb buds and functions as part of a self-regulatory feedback signaling system, which is essential for normal limb bud development and digit formation. Inhibition of BMPs by Grem1 in limb buds allows the transcriptional up-regulation of the fibroblast growth factors (FGFs) 4 and 8 and sonic hedgehog (SHH) ligands, which are part of the signaling system that controls progression of limb bud development. Grem1 regulation of BMP4 in mice embryos is also essential for kidney and lung branching morphogenesis.
Clinical significance
Cancer
Data from microarrays of cancer and non-cancer tissues suggest that grem1 and other BMP antagonists are important in the survival of cancer stroma and proliferation in some cancers. Grem1 expression is found in many cancers and is thought to play important roles in ute |
https://en.wikipedia.org/wiki/Cerberus%20%28protein%29 | Cerberus is a protein that in humans is encoded by the CER1 gene. Cerberus is a signaling molecule which contributes to the formation of the head, heart and left-right asymmetry of internal organs. This gene varies slightly from species to species but its overall functions seem to be similar.
Cerberus is secreted by the anterior visceral endoderm and blocks the action of BMP, Nodal and Wnt, secreted by the primitive node, which allows for the formation of a head region. This is accomplished by inhibiting the formation of mesoderm in this region. Xenopus Cerberus causes a protein to be secreted that is able to induce the formation of an ectopic head. Knockdown experiments have helped to explain Cerberus's role in both the formation of the head and left and right symmetry. These experiments have shown that Cerberus helps to keep Nodal from crossing to the right side of the developing embryo, allowing left and right asymmetry to form. This is why misexpression of Cerberus can cause the heart to fold in the opposite direction during development. When Cerberus is “knocked down” and BMP and Wnt are up regulated the head does not form. Other experiments using mice that this gene has been “knocked out” showed no head defects, which suggest that it is the combination of the up regulation of BMP and Wnt along with the absence of Cerberus that causes this defect. For the heart, Cerberus is one of several factors that inhibits Nodal to initiate cardiomyogenic differentiation
The Cerb |
https://en.wikipedia.org/wiki/Poly%28A%29-binding%20protein | Poly(A)-binding protein (PAB or PABP) is an RNA-binding protein which triggers the binding of eukaryotic initiation factor 4 complex (eIF4G) directly to the poly(A) tail of mRNA which is 200-250 nucleotides long. The poly(A) tail is located on the 3' end of mRNA and was discovered by Mary Edmonds, who also characterized the poly-A polymerase enzyme that generates the poly(a) tail. The binding protein is also involved in mRNA precursors by helping polyadenylate polymerase add the poly(A) nucleotide tail to the pre-mRNA before translation. The nuclear isoform selectively binds to around 50 nucleotides and stimulates the activity of polyadenylate polymerase by increasing its affinity towards RNA. Poly(A)-binding protein is also present during stages of mRNA metabolism including nonsense-mediated decay and nucleocytoplasmic trafficking. The poly(A)-binding protein may also protect the tail from degradation and regulate mRNA production. Without these two proteins in-tandem, then the poly(A) tail would not be added and the RNA would degrade quickly.
Structure
Cytosolic poly-A binding protein (PABPC) is made up of four RNA recognition motifs (RRMs) and a C-terminal region known as the PABC domain. RRM is the most common motifs for RNA recognition and is usually made up of 90-100 amino acids. Previous solution NMR and X-ray crystallography studies have shown that RRMs are globular domains, each composed of 4 anti-parallel β sheets that are backed by 2 α-helices. The central two β- |
https://en.wikipedia.org/wiki/Picosecond%20ultrasonics | Picosecond ultrasonics is a type of ultrasonics that uses ultra-high frequency ultrasound generated by ultrashort light pulses. It is a non-destructive technique in which picosecond acoustic pulses penetrate into thin films or nanostructures to reveal internal features such as film thickness as well as cracks, delaminations and voids. It can also be used to probe liquids. The technique is also referred to as picosecond laser ultrasonics or laser picosecond acoustics.
Introduction
When an ultrashort light pulse, known as the pump pulse, is focused onto a thin opaque film on a substrate, the optical absorption results in a thermal expansion that launches an elastic strain pulse. This strain pulse mainly consists of longitudinal acoustic phonons that propagate directly into the film as a coherent pulse.
After acoustic reflection from the film-substrate interface, the strain pulse returns to the film surface, where it can be detected by a delayed optical probe pulse through optical reflectance or (for films that are thin enough) transmittance changes. This time-resolved method for generation and photoelastic detection of coherent picosecond acoustic phonon pulses was proposed by Christian Thomsen and coworkers in a collaboration between Brown University and Bell Laboratories in 1984.
Initial development took place in Humphrey Maris’s group at Brown University and elsewhere in the late 1980s.
In the early 1990s the method was extended in scope at Nippon Steel Corp. by direct |
https://en.wikipedia.org/wiki/Polypyrimidine%20tract-binding%20protein | Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons. These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.
See also
Polypyrimidine tract
References
External links |
https://en.wikipedia.org/wiki/Nuclear%20cap-binding%20protein%20complex | Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary structure contains approximately sixty percent of helical and one percent of beta sheet in the strand. The small subunit, CBC20 has 98 amino acid residues. Its secondary structure contains approximately twenty percent of helical and twenty-four percent of beta sheet in the strand. Human nuclear cap-binding protein complex plays important role in the maturation of pre-mRNA and in uracil-rich small nuclear RNA.
References
External links
RNA-binding proteins |
https://en.wikipedia.org/wiki/Cap%20binding%20complex | The 5' cap of eukaryotic messenger RNA is bound at all times by various cap-binding complexes (CBCs).
Nuclear cap-binding complex
In the nucleus, freshly transcribed mRNA molecules are bound on the 5' cap by the nuclear cap-binding complex of Cbc1/Cbc2 in yeast or CBP20/CBP80 in metazoans. These aid in the export of the mRNA and protect it from decapping. They also serve as a marker for the so-called pioneer round of translation when the message is examined by nonsense mediated decay.
Cytoplasmic cap-binding complex
After the first round of translation ("pioneer round"), CBC20/80 is replaced by the translation initiation factor eIF4E. The eIF4F complex (eIF4E, eIF4G and eIF4A) then regulates translation in response to the state of the cell via its phosphorylation state and again protects the message from decapping.
Decapping complex
When translationally repressed or marked for decay by various mechanisms the 5' cap is bound by the mRNA decapping enzyme DCP2. A host of proteins accompany it including UPF1, UPF2, UPF3A, Dcp1, Dhh1, XRN1, and others. The decapping enzyme removes the 5' cap leading to destruction of the message.
References
External links
RNA |
https://en.wikipedia.org/wiki/Roscoe%20Dsane | Roscoe Niiquaye Dsane (born 16 October 1980) is an English professional footballer who last played for Isthmian Division One South side Walton Casuals as a striker.
A Crystal Palace youth product, Dsane made his professional debut for Southend United before spells at Slough Town and Woking in 2002. He joined Aldershot Town in May 2002 for a three-year stint, followed by moves to Wealdstone and Lewes. In July 2006, Dsane joined AFC Wimbledon and earned a move to Accrington Stanley a year later. In January 2008, he completed a move to Torquay United for an undisclosed fee. Following a year-long absence, Dsane returned to AFC Wimbledon in 2011, followed by moves to Merstham and Whyteleafe. He joined current club Walton Casuals in December 2016.
Dsane has represented England at semi-professional level, scoring four times for the National Game XI.
Career
Born in Epsom, Dsane spent four years as a junior with Crystal Palace before joining Southend United in November 2001. He made his debut as a second-half substitute for Leon Johnson in Southend's 1–0 defeat at home to Plymouth Argyle and started the next game, a 2–0 defeat away to Shrewsbury Town. These were to be his only first team appearances for Southend and he moved to Slough Town on a free transfer and then to Woking in January 2002.
He moved to Aldershot Town in May 2002 and helped Aldershot to promotion to the Conference at the end of the following season. He scored 21 goals for Aldershot to help them to the playoff fi |
https://en.wikipedia.org/wiki/All%20My%20Tomorrows%20%28Crystal%20Gayle%20album%29 | All My Tomorrows is an album by the American country music singer Crystal Gayle. Released on September 30, 2003, it was Gayle first studio album of mainstream songs in several years (her previous few albums being either gospel/Christian music or children's songs).
The album is a collection of classic standards including Jo Stafford's "You Belong to Me" and the ballad "Cry Me a River".
Track listing
References
2003 albums
Crystal Gayle albums |
https://en.wikipedia.org/wiki/Eggomania | Eggomania is an action video game released in January 1983 by U.S. Games for the Atari 2600. Similar in design to Kaboom!, which itself is a derivative of the arcade game Avalanche, the objective is to catch eggs in a hat which are thrown by a chicken.
Gameplay
A chicken at the top of the screen moves back and forth, dropping eggs. The paddle controller is used to move a blue bear holding a hat over its head left and right at the bottom of the screen. The goal is to catch the eggs in the hat. At the end of each round, the player has a chance to throw the eggs they have caught back at the chicken for bonus points. The speed of the game increases as the player progresses.
The game has two difficulties; the easier variation gives the player a larger hat for catching eggs.
Reception
Electronic Games in June 1983 called Eggomania "delightful," stating that the game improved on Kaboom! and Avalanche as a "fully-animated delight that might even eclipse its inspiration" with "state-of-the-art graphics on the 2600".
See also
Chicken
References
External links
Eggomania at Atari Mania
1983 video games
Action games
Atari 2600 games
Atari 2600-only games
Fictional chickens
Video games about bears
Video games about birds
Video games developed in the United States
U.S. Games games |
https://en.wikipedia.org/wiki/Entropy%20power%20inequality | In information theory, the entropy power inequality (EPI) is a result that relates to so-called "entropy power" of random variables. It shows that the entropy power of suitably well-behaved random variables is a superadditive function. The entropy power inequality was proved in 1948 by Claude Shannon in his seminal paper "A Mathematical Theory of Communication". Shannon also provided a sufficient condition for equality to hold; Stam (1959) showed that the condition is in fact necessary.
Statement of the inequality
For a random vector X : Ω → Rn with probability density function f : Rn → R, the differential entropy of X, denoted h(X), is defined to be
and the entropy power of X, denoted N(X), is defined to be
In particular, N(X) = |K| 1/n when X is normal distributed with covariance matrix K.
Let X and Y be independent random variables with probability density functions in the Lp space Lp(Rn) for some p > 1. Then
Moreover, equality holds if and only if X and Y are multivariate normal random variables with proportional covariance matrices.
Alternative form of the inequality
The entropy power inequality can be rewritten in an equivalent form that does not explicitly depend on the definition of entropy power (see Costa and Cover reference below).
Let X and Y be independent random variables, as above. Then, let X' and Y' be independently distributed random variables with gaussian distributions, such that
and
Then,
See also
Information entropy
Information theory
Limi |
https://en.wikipedia.org/wiki/Fenna%E2%80%93Matthews%E2%80%93Olson%20complex | The Fenna–Matthews–Olson (FMO) complex is a water-soluble complex and was the first pigment-protein complex (PPC) to be structure analyzed by x-ray spectroscopy. It appears in green sulfur bacteria and mediates the excitation energy transfer from light-harvesting chlorosomes to the membrane-embedded bacterial reaction center (bRC). Its structure is trimeric (C3-symmetry). Each of the three monomers contains eight bacteriochlorophyll a (BChl a) molecules. They are bound to the protein scaffold via chelation of their central magnesium atom either to amino acids of the protein (mostly histidine) or water-bridged oxygen atoms (only one BChl a of each monomer).
Since the structure is available, calculating structure-based optical spectra is possible for comparison with experimental optical spectra. In the simplest case only the excitonic coupling of the BChls is taken into account. More realistic theories consider pigment-protein coupling. An important property is the local transition energy (site energy) of the BChls, different for each, due to their individual local protein environment. The site energies of the BChls determine the direction of the energy flow.
Some structural information on the FMO-RC super complex is available, which was obtained by electron microscopy and linear dichroism spectra measured on FMO trimers and FMO-RC complexes. From these measurements, two orientations of the FMO complex relative to the RC are possible. The orientation with BChl 3 and 4 close t |
https://en.wikipedia.org/wiki/Tyrosine%20kinase%202 | Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.
TYK2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.
Function
This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity.
Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation, and function of immune cells, as well as cells from other organ systems. Hence, targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to affect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases, which associate with their cognate receptors.
The mammalian JAK family has four members: JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). The connection between Jaks and cytokine signaling was first revealed when a screen for genes involved in interferon type I (IFN-1) signaling identified TYK2 as an es |
https://en.wikipedia.org/wiki/Janus%20kinase%203 | Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.
Janus kinases
Janus kinase 3 is a tyrosine kinase that belongs to the janus family of kinases. Other members of the Janus family include JAK1, JAK2 and TYK2. Janus kinases (JAKs) are relatively large kinases of approximately 1150 amino acids with apparent molecular weights of 120-130 kDa. They are cytosolic tyrosine kinases that are specifically associated with cytokine receptors. Since cytokine receptor proteins lack enzymatic activity, they are dependent upon JAKs to initiate signaling upon binding of their ligands (e.g. cytokines). The cytokine receptors can be divided into five major subgroups based on their different domains and activation motifs. JAK3 is required for signaling of the type I receptors that use the common gamma chain (γc).Studies suggest Jak3 plays essential roles in immune and nonimmune cell physiology. Epithelial Jak3 is important for the regulation of epithelial-mesenchymal transition, cell survival, cell growth, development, and differentiation. Growth factors and cytokines produced by the cells of hematopoietic origin use Jak kinases for signal transduction in both immune and nonimmune cells. Among Jaks, Jak3 is widely expressed in both immune cells and in intestinal epithelial cells (IECs) of both humans and mice. Mutations that abrogate Jak3 functions cause an autosomal severe combined immunodeficiency disease (SCID) while activating Jak3 mutati |
https://en.wikipedia.org/wiki/Janus%20kinase%201 | JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
Interactions
Janus kinase 1 has been shown to interact with:
ELP2,
GNB2L1
IL6ST,
Grb2,
IL2RB,
IRS1,
IL10RA,
PTPN11,
STAM2,
STAT3,
STAT5A,
STAT5B, and
TNFRSF1A.
See also
Janus kinase inhibitor
References
Further reading
External links
Tyrosine kinases |
https://en.wikipedia.org/wiki/ETV6 | ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. However, its gene, ETV6 frequently suffers various mutations that lead to an array of potentially lethal cancers, i.e., ETV6 is a clinically significant proto-oncogene in that it can fuse with other genes to drive the development and/or progression of certain cancers. However, ETV6 is also an anti-oncogene or tumor suppressor gene in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers.
Gene
The human ETV6 gene is located at position "13.2" on the short (i.e. "p") arm of chromosome 12, i.e. its notated position is 12p13.2. The gene has 8 exons and two start codons, one located at exon 1 at the start of the gene and an alternative located upstream of exon 3. ETV6 codes for a full length protein consisting of 452 amino acids; the gene is expressed in virtually all cell types and tissues. Mice depleted of the ETV6 gene by Gene knockout die between day 10.5 and 11.5 of embryonic life with defective yolk sac angiogenesis and extensive losses in mesenchymal and neural cells due to apoptosis. Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of bone marrow-based blood cell for |
https://en.wikipedia.org/wiki/Bonnet%20theorem | In the mathematical field of differential geometry, the fundamental theorem of surface theory deals with the problem of prescribing the geometric data of a submanifold of Euclidean space. Originally proved by Pierre Ossian Bonnet in 1867, it has since been extended to higher dimensions and non-Euclidean contexts.
Bonnet's theorem
Any surface in three-dimensional Euclidean space has a first and second fundamental form, which automatically are interrelated by the Gauss–Codazzi equations. Bonnet's theorem asserts a local converse to this result.
Given an open region in , let and be symmetric 2-tensors on , with additionally required to be positive-definite. If these are smooth and satisfy the Gauss–Codazzi equations, then Bonnet's theorem says that is covered by open sets which can be smoothly embedded into with first fundamental form and second fundamental form (relative to one of the two choices of unit normal vector field) . Furthermore, each of these embeddings is uniquely determined up to a rigid motion of .
Bonnet's theorem is a corollary of the Frobenius theorem, upon viewing the Gauss–Codazzi equations as a system of first-order partial differential equations for the two coordinate derivatives of the position vector of an embedding, together with the normal vector.
General formulations
Bonnet's theorem can be naturally formulated for hypersurfaces in a Euclidean space of any dimension, and the result remains true in this context. Furthermore, the theorem can b |
https://en.wikipedia.org/wiki/James%20S.%20Harris | James S. Harris is a scientist and engineer and fellow of IEEE, American Physical Society and Optical Society of America. His research primarily deals with optoelectronic devices and semiconductor material research.
Since 1982, he is the James and Elenor Chesebrough Professor of Electrical Engineering, Applied Physics and Material Science at Stanford University.
Harris was elected a member of the National Academy of Engineering in 2011 for contributions to epitaxial growth of compound semiconductor materials and their applications.
Education
Harris completed his BS (1964), MS (1965), and PhD (1969) – all in electrical engineering – from Stanford University.
Career
Prior to joining the Stanford department of electrical engineering in 1982, James Harris was with Rockwell International Science Center, where he held various positions from technical staff member to director optoelectronics research.
Research
Harris’ research interests are in the areas of new electronic and optoelectronic device structures created by heterojunctions, quantum wells, superlattices and nanostructured materials. He has carried out research on novel semiconductor materials and their growth at atomic level dimensions for the past 50 years.
Harris has been issued approximately 37 patents as of this publication (2019).
Awards
1988 IEEE Fellow
1992 American Physical Society Fellow
2005 Optical Society of America Fellow
2000 IEEE Third Millennium Medal
2000 IEEE Morris N. Liebmann Memorial Award
|
https://en.wikipedia.org/wiki/Biodiversity%20Outcomes%20Framework | Canada's Biodiversity Outcomes Framework was approved by Ministers responsible for Environment, Forests, Parks, Fisheries and Aquaculture, and Wildlife in October 2006. It has been developed further to the Canadian Biodiversity Strategy, an implementation measure required under Article 6 of the United Nations Convention on Biological Diversity.
Criticism of the Framework
The Framework has been developed from the Canadian Biodiversity Strategy, which has been criticized as having a tendency to focus on species and to assign less importance to other scales of biodiversity from the genetic to the ecosystem level.
See also
Criticisms of the biodiversity paradigm
References
External links
Convention on Biological Diversity
Biodiversity Convention Office
Environment Canada
Ecology organizations
Environment and Climate Change Canada
Convention on Biological Diversity |
https://en.wikipedia.org/wiki/Biodiversity%20Convention%20Office | Canada's Biodiversity Convention Office (BCO) serves as National Focal Point for the United Nations Convention on Biological Diversity and the Canadian Biodiversity Strategy. BCO also provides a leadership role in the Biodiversity Conservation Working Group of the Commission for Environmental Cooperation and in the Conservation of Arctic Flora and Fauna (CAFF) working group of the Arctic Council.
The BCO was established by Environment Canada in September 1991 to coordinate Canadian involvement in the negotiations of the Convention. Following Canada's ratification of the Convention in December 1992, attention shifted to development of a Canadian response. Under the guidance of the BCO, a Federal-Provincial-Territorial Working Group was charged by the Canadian Council of Ministers of the Environment with developing the Canadian Biodiversity Strategy. In 1996, all jurisdictions signed a statement of commitment to use the Strategy as a guide to implementing the Convention in Canada. In 2005, Ministers instructed the Federal-Provincial-Territorial Working Group to develop a corresponding outcomes-based framework for guiding and monitoring implementation of the Canadian Biodiversity Strategy. This Biodiversity Outcomes Framework was approved by Ministers responsible for Environment, Forests, Parks, Fisheries and Aquaculture, and Wildlife in October 2006.
The BCO plays a policy coordinating, catalysing and facilitating role in national efforts to define Canada's response to the |
https://en.wikipedia.org/wiki/Canadian%20Biodiversity%20Strategy | The Canadian Biodiversity Strategy has been prepared in response to Canada's obligations as a party to the United Nations Convention on Biological Diversity. The Strategy has been developed as a guide to the implementation of the Biodiversity Convention in Canada.
Recognition of the worldwide impact of the decline of biodiversity inspired the global community to negotiate the United Nations Convention on Biological Diversity. The Canadian delegation participated in the negotiations, the Prime Minister signed the Convention at the Earth Summit in June 1992 and, in December 1992, Canada ratified it. Prior ratifying parties included Mauritius, Maldives, and Monaco.
One of the key obligations for parties that have ratified the Convention is to prepare a national strategy.
Elements of the Strategy
The Strategy contains guiding principles supporting a vision of society that lives sustainably, and contains a framework for action to support sustainable development as part of international efforts to implement the Convention on Biological Diversity. The Strategy goals are related to conservation, education, support, and collaboration.
In 2015, Canada adopted 19 targets to fulfill its obligations under the treaty. The first was to conserve at least 17% of terrestrial area and inland water, and 10% of coastal and marine areas, through "networks of protected areas and other effective area-based conservation measures." By the end of 2019, Canada was not on track to meeting its fi |
https://en.wikipedia.org/wiki/Canadian%20Biodiversity%20Information%20Network | The Canadian Biodiversity Information Network (CBIN) was developed in 1996 to deliver information on the Canadian Biodiversity Strategy and to serve as Canada's national node to the global Clearing House Mechanism. CBIN facilitates biodiversity-relevant information-sharing as part of Canada's implementation of the United Nations Convention on Biological Diversity.
See also: Criticisms of the biodiversity paradigm
References
External links
Convention on Biological Diversity
Biodiversity Convention Office
Environment Canada
Environment of Canada
Environment and Climate Change Canada |
https://en.wikipedia.org/wiki/Mathieu%20wavelet | The Mathieu equation is a linear second-order differential equation with periodic coefficients. The French mathematician, E. Léonard Mathieu, first introduced this family of differential equations, nowadays termed Mathieu equations, in his “Memoir on vibrations of an elliptic membrane” in 1868. "Mathieu functions are applicable to a wide variety of physical phenomena, e.g., diffraction, amplitude distortion, inverted pendulum, stability of a floating body, radio frequency quadrupole, and vibration in a medium with modulated density"
Elliptic-cylinder wavelets
This is a wide family of wavelet system that provides a multiresolution analysis. The magnitude of the detail and smoothing filters corresponds to first-kind Mathieu functions with odd characteristic exponent. The number of notches of these filters can be easily designed by choosing the characteristic exponent. Elliptic-cylinder wavelets derived by this method possess potential application in the fields of optics and electromagnetism due to its symmetry.
Mathieu differential equations
Mathieu's equation is related to the wave equation for the elliptic cylinder. In 1868, the French mathematician Émile Léonard Mathieu introduced a family of differential equations nowadays termed Mathieu equations.
Given , the Mathieu equation is given by
The Mathieu equation is a linear second-order differential equation with periodic coefficients. For q = 0, it reduces to the well-known harmonic oscillator, a being the square |
https://en.wikipedia.org/wiki/Days%20of%20Memories | Days of Memories is a series of dating sims from SNK for cell phones, beginning in 2005. SNK released a compilation of the first three games for the Nintendo DS in 2007, with new graphics and an extra viewing mode.
Summary
The games are dating sims starring SNK and ADK characters that take place in a parallel world to their own. In each game, the player is given the month of July to start a relationship with one of the girls featured in the game, in order to finish the game with the beginnings of a workable relationship.
Games
Released on October 17th, 2005.
The cast of this game is considered to be fan favorites from their respective debut games.
Features - Athena Asamiya, Kasumi Todoh, B. Jenet, King, Mai Shiranui, Yuri Sakazaki, Leona Heidern, Kula Diamond.
Male characters - Kyoya Kaido (original)
Released on February 1st, 2006.
Debuted the first unique Days Of Memories character.
Features - Hotaru Futaba, Kisarah Westfield, Fiolina "Fio" Germi, Chizuru Kagura, Mature, Blue Mary.
Male characters - Kyo Kusanagi, Iori Yagami
Exclusive character - Shizuku Misawa.
Released on May 15th, 2006.
Is set during the era of Feudal Japan.
It is the first game in the series to show where the girls are.
Features - Nakoruru, Mina Majikina, Rinka Yoshino, Saya, Mikoto, Shiki, Iroha.
Male characters - Haohmaru, Genjuro Kibagami, Ukyo Tachibana, Kyouemon (original)
Exclusive characters - Shino, Chiyo.
This game features only Samurai Shodown characters, rather than the normal cast o |
https://en.wikipedia.org/wiki/Norberto%20Esbrez | Norberto Esbrez (November 22, 1966 - July 16, 2014) was an Argentine tango dancer, choreographer and teacher.
A dancer and teacher of tango nuevo, he was known as El Pulpo or octopus for his fluid and intricate leg moves. Esbrez created and named several tango movements including: ocho loco, sentada girada, elevador, or el elástico. He explored the concept of trap sacadas (sacadas con agarre) and enganches into innovative variations.
His style was so well known that when the dancer starts combining several leg moves that look like Pulpo's it is being called pulpeadas. He developed the concept of suspension as a tool to generate the control and fluidity that is part of his dance.
He worked for theaters and show-places in Buenos Aires, such as: Teatro San Martin, Teatro Astral, Teatro Opera, Cafe Tortoni, El Viejo Almacen, La Ventana, Casablanca. He taught in Brazil as a member of the Academia Argentina de Tango. One of Esbrez's partners was Luiza Paes - they were part of the International Congress of Argentine Tango in Buenos Aires.
He died on July 16, 2014, in Buenos Aires of complications of a liver disease.
See also
List of dancers
References
1966 births
2014 deaths
Dancers from Buenos Aires
Tango dancers and choreographers
Argentine male dancers
Argentine dancers
Argentine choreographers |
https://en.wikipedia.org/wiki/Halbert%20L.%20Dunn%20Award | The Halbert L. Dunn Award is the most prestigious award presented by the National Association for Public Health Statistics and Information Systems (NAPHSIS). The award has been presented since 1981 providing national recognition of outstanding and lasting contributions to the field of vital and health statistics at the national, state, or local level.
The award was established in honor of the late Halbert L. Dunn, M.D., Director of the National Office of Vital Statistics from 1936 to 1960. Dr. Dunn was highly instrumental in encouraging the states to establish state vital statistics associations and played a major role in developing NAPHSIS. The award is presented at the Hal Dunn Awards Luncheon during the association’s annual meeting.
The winners of the Halbert L. Dunn Award have been:
Source: NAPHSIS
1981 Deane Huxtable
1982 Loren Chancellor
1983 Vito Logrillo
1984 Carl Erhardt
1985 Irvin Franzen
1986 W. D. "Don" Carroll
1987 Margaret Shackelford
1988 John Brockert, State Registrar, Utah
1989 Margaret Watts
1990 John Patterson
1991 Patricia Potrzebowski, State Registrar, Pennsylvania
1992 Rose Trasatti, National Association for Public Health Statistics and Information Systems (NAPHSIS)
1993 Garland Land, State Registrar, Missouri
1994 George Van Amburg
1995 Jack Smith
1996 no award
1997 Ray Nashold
1998 Iwao Moriyama
1999 no award
2000 George Gay
2001 Dorothy Harshbarger, State Registrar, Alabama
2002 Lorne Phillips, State Registrar, Kansas
2 |
https://en.wikipedia.org/wiki/Sami%20Brady%20and%20EJ%20DiMera | Elvis "EJ" Aaron DiMera and Samantha "Sami" Gene Brady DiMera (also known by the portmanteau EJami for EJ and Sami) are fictional characters and a supercouple from the American soap opera Days of Our Lives. Since 1993, the role of Sami Brady has been portrayed by actress Alison Sweeney. James Scott originally portrayed the role of EJ DiMera when the character was introduced on May 30, 2006, but in 2021 when EJ finally returns for the first time on-screen since his supposed death in 2014, he is now portrayed by actor Dan Feuerriegel. Scott says that his days of acting are now behind him.
The pairing is noted for a controversial storyline in which EJ is considered to have raped Sami. They are also noted for being a popular pairing.
Storyline
2006–2007
EJ Wells, a famous European race car driver and entrepreneur, arrives in Salem and moves into the apartment across the hall from Sami Brady on 30 May 2006. The attraction between the handsome, charming Brit and Salem's resident bad girl is instantaneous and they quickly become good friends, despite her romantic relationship with Austin Reed at the time. Over that summer, EJ and Sami share a number of flirtatious exchanges and romantic moments. Ultimately, Sami leaves Austin at the altar to satisfy the person blackmailing her. She's also forced to give up custody of her son, Will, to her ex-fiancé, Lucas Horton. EJ promises her that he will always be there for her, and they kiss.
Shortly thereafter, Sami's secret is revealed w |
https://en.wikipedia.org/wiki/Tanguar%20Haor | Tanguar Haor (), located in the Dharmapasha and Tahirpur upazilas of Sunamganj District in Bangladesh, is a unique wetland ecosystem of national importance and has come into international focus. The area of Tanguar Haor including 46 villages within the haor is about of which 2,802.36 ha2 is wetland. It is the source of livelihood for more than 40,000 people. Bangladesh declared it an Ecologically Critical Area in 1999 considering its critical condition as a result of overexploitation of its natural resources.
Every winter the haor is home to about 200 types of migratory birds. In 1999–2000, the government earned 7,073,184 takas as revenue just from fisheries of the haor. There are more than 140 species of fresh water fish in the haor. The more predominant among them are: , Cat fish, . Gulli, balua, ban tulsi, nalkhagra and other freshwater wetland trees are in this haor.
Plant species like Hizol (Barringtonia acutangula), Clematis cadmia, Crataeva nurvala, Euryale ferox, Nelumbo nucifera, Ottelia alismoides, Oxystelma secamone var. secamone, Pongamia pinnata, Rosa clinophylla, and Typha species are present.
Houseboat
It has become more popular with tourists as a tourist attraction due to the number of houseboats plying at Tanguar Haor. There is a big houseboat in Tanguar Haor. It is a huge, slow-moving barges used for leisure trips. This service is inspired from the houseboat Rabindranath Tagore used during his visit to Shilaidaha. It is in service from since 2021. It is |
https://en.wikipedia.org/wiki/Approximate%20Bayesian%20computation | Approximate Bayesian computation (ABC) constitutes a class of computational methods rooted in Bayesian statistics that can be used to estimate the posterior distributions of model parameters.
In all model-based statistical inference, the likelihood function is of central importance, since it expresses the probability of the observed data under a particular statistical model, and thus quantifies the support data lend to particular values of parameters and to choices among different models. For simple models, an analytical formula for the likelihood function can typically be derived. However, for more complex models, an analytical formula might be elusive or the likelihood function might be computationally very costly to evaluate.
ABC methods bypass the evaluation of the likelihood function. In this way, ABC methods widen the realm of models for which statistical inference can be considered. ABC methods are mathematically well-founded, but they inevitably make assumptions and approximations whose impact needs to be carefully assessed. Furthermore, the wider application domain of ABC exacerbates the challenges of parameter estimation and model selection.
ABC has rapidly gained popularity over the last years and in particular for the analysis of complex problems arising in biological sciences, e.g. in population genetics, ecology, epidemiology, systems biology, and in radio propagation.
History
The first ABC-related ideas date back to the 1980s. Donald Rubin, when discussin |
https://en.wikipedia.org/wiki/BRN-3 | BRN-3 is a group of related transcription factors in the POU family. They are also known as class 4 POU domain homeobox proteins.
There are three BRN-3 proteins encoded by the following genes:
BRN3A (POU4F1, )
BRN3B (POU4F2, )
BRN3C (POU4F3, )
Nomenclature
The BRN or Brn prefix is an abbreviation for "brain"; the longer name is "Brain-specific homeobox". The name of the group may also be abbreviated as POU4, Pou4, POU IV, or POU-IV.
References
External links
Transcription factors |
https://en.wikipedia.org/wiki/Centromere%20protein%20B | Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.
Function
Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Clinical significance
Centromere protein B is a potential biomarker of small-cell lung cancer.
See also
Centromere
References
Further reading
External links |
https://en.wikipedia.org/wiki/Cottrell%20equation | In electrochemistry, the Cottrell equation describes the change in electric current with respect to time in a controlled potential experiment, such as chronoamperometry. Specifically it describes the current response when the potential is a step function in time. It was derived by Frederick Gardner Cottrell in 1903. For a simple redox event, such as the ferrocene/ferrocenium couple, the current measured depends on the rate at which the analyte diffuses to the electrode. That is, the current is said to be "diffusion controlled". The Cottrell equation describes the case for an electrode that is planar but can also be derived for spherical, cylindrical, and rectangular geometries by using the corresponding Laplace operator and boundary conditions in conjunction with Fick's second law of diffusion.
where,
= current, in units of A
= number of electrons (to reduce/oxidize one molecule of analyte , for example)
= Faraday constant, 96485 C/mol
= area of the (planar) electrode in cm2
= initial concentration of the reducible analyte in mol/cm3;
= diffusion coefficient for species in cm2/s
= time in s.
Deviations from linearity in the plot of vs. sometimes indicate that the redox event is associated with other processes, such as association of a ligand, dissociation of a ligand, or a change in geometry.
In practice, the Cottrell equation simplifies to where is the collection of constants for a given system (, , ).
See also
Voltammetry
Electroanalytical methods
Lim |
https://en.wikipedia.org/wiki/Winnie%20Hsin | Winnie Hsin (; born 8 February 1962) is a Taiwanese singer. She is best known for her crystal clear soprano voice.
Biography
In 1976, Hsin was admitted to the Taipei Hwa Kang Arts School, and in 1979 she studied music in the Chinese Culture University in Taipei. After graduating, she became a music teacher in the Yamaha Music School in Taipei. She released her first album, Lonely Winter, in 1986, and has since released a total of 16 albums, under the labels of Decca Records, Rock Records and Warner Music.
In 1995, Hsin provided the voice of the titular character in the Mandarin dubbed version of the Walt Disney animated film Pocahontas. She also performed the Mandarin version of the film's theme song, Colours of the Wind, and some other songs in the soundtrack.
In 2003, Hsin starred as Zhu Yingtai in a Taiwanese musical based on the Chinese legend of the Butterfly Lovers.
In 2006, Hsin held two solo concerts in Taiwan on 30 June and 1 July, called Winnie Hsin "The Promise" Concert.
In 2007, Hsin held another concert in Genting Highlands, Malaysia, on 26 July 2008.
In 2007, Hsin endorsed one of Avon's ANEW Alternative beauty care products.
On 7 July 2007, Hsin performed at the Live Earth concert held in Shanghai.
On 30 May 2009, Hsin performed in the Join, Love Club concert held at the Hong Kong Coliseum.
In 2009, Hsin held her first solo ticketed concert in Shanghai on 18 Dec 2009.
In 2010, Hsin held another solo ticketed concert in Chengdu on 21 Aug 2010.
In 2011, |
https://en.wikipedia.org/wiki/List%20of%20Sheffield%20United%20F.C.%20records%20and%20statistics | This article lists honours and records associated with Sheffield United F.C..
Club honours and best performances
Major domestic competitions
Leagues
First Division / Premier League (level 1)
Champions (1): 1897–98
Runners up (2): 1896–97, 1899–1900
Second Division / First Division / Championship (level 2)
Champions (1): 1952–53
Runners-up (7): 1892–93, 1938–39, 1960–61, 1970–71, 1989–90, 2005–06, 2018–19, 2022–23 (as The Championship)
Third Division / Third Division South / Second Division / League One (level 3)
Champions (1): 2016–17 (as League One)
Runners-up (1): 1988–89
Promoted in third place (1): 1983–84
Fourth Division / Third Division / League Two (level 4)
Champions (1): 1981–82
Football League North
Champions (1): 1945–46
Cups
FA Cup
Winners (4): 1899, 1902, 1915, 1925
Runners-up (2): 1901, 1936
Football League Cup
Best performance: Semi-final – 2002–03, 2014–15
Football League Trophy
Best performance: North quarter-final – 2011–12, 2012–13, 2014–15, 2015–16
Club records
League
Record League Win: 10–0 away v Port Vale, Division Two, 10 December 1892 (Goals scored by Drummond, Wallace, Hammond (4), Watson (2) & Davies (2)) and 10–0 home v Burnley, Division One, 19 January 1929 (Goals scored by Harry Johnson 8th, 11th, 49th, 64th, Fred Tunstall 59th, 67th pen, Tom Phillipson 68th, 87th, Billy Gillespie 77th & Sid Gibson 86th)
Record League defeat: 0–8 home v Newcastle United, Premier League, 24 September 2023
Most League Points in a Season (2 p |
https://en.wikipedia.org/wiki/ErbB | The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. In humans, the family includes Her1 (EGFR, ErbB1), Her2 (ErbB2), Her3 (ErbB3), and Her4 (ErbB4). The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor.
ErbB protein family signaling is important for development. For example, ErbB-2 and ErbB-4 knockout mice die at midgestation leads to deficient cardiac function associated with a lack of myocardial ventricular trabeculation and display abnormal development of the peripheral nervous system. In ErbB-3 receptor mutant mice, they have less severe defects in the heart and thus are able to survive longer throughout embryogenesis. Lack of Schwann cell maturation leads to degeneration of motor and sensory neurons. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors.
Family members
The ErbB protein family consists |
https://en.wikipedia.org/wiki/Digital%20Mars | Digital Mars is a small American software company owned by Walter Bright and based in Vienna, Virginia. It makes C, C++, and D compilers, and associated utilities such as an integrated development environment (IDE) for Windows and DOS, which Digital Mars calls an integrated development and debugging environment (IDDE).
The compilers can be downloaded, free of charge, from Digital Mars's web site.
Product names changed over time. The C compiler was first named Datalight C compiler, then Zorland C, then Zortech C, then Digital Mars C/C++ compiler. The C++ compiler was first named Zortech C++, then Symantec C++, then Digital Mars C++ (DMC++).
The company gained notice in the software development community for creating the D programming language. D resulted from Bright's frustration with the direction of the C++ language and from his experience implementing it.
Digital Mars is also notable for having shipped the first commercial C++ compiler for Windows
In 2002, Digital Mars released DMDScript, an ECMA-262-compliant JavaScript engine, written in D.
History
In 1988, Zortech was the first C++ compiler to ship for Windows. PC Magazine ran a graphics benchmark, and reported that most executables produced by Zortech ran faster than executables produced by Microsoft C 5.1 and by Watcom C 6.5. Stanley B. Lippman wrote that Zortech was the first C++ compiler to implement return value optimization. Later, the C++ standard required this.
In 2023, Mike Engelhardt released a new simula |
https://en.wikipedia.org/wiki/Exon%20%28disambiguation%29 | Exon may refer to:
Exon, a region of DNA that is represented in the mature form of RNA
Exoribonuclease or ExoN, an RNA degrading enzyme
Exoniensis or Exon., the Post-Nominal Letters for alumni / degrees from the University of Exeter
Exon can also refer to the signature of the Bishop of Exeter
J. James Exon (1921–2005), American politician
Nat Exon (born 1992), Australian rules footballer
Exon is a rank for an officer in the Yeomen of the Guard
It may also be a spelling error for:
ExxonMobil, the energy company
Exxon, a brand of fuel sold by ExxonMobil |
https://en.wikipedia.org/wiki/Cystic%20eyeball | Congenital cystic eye (also known as CCE or cystic eyeball) is an extremely rare ocular malformation where the eye fails to develop correctly in utero and is replaced by benign, fluid-filled tissue. Its incidence is unknown, due to the very small number of cases reported. An audit by Duke-Elder of the medical literature from 1880 to 1963 discovered only 28 cases. The term was coined in 1937 by the renowned ophthalmologist Ida Mann.
Embryologically, the defect is thought to occur around day 35 of gestation, when the vesicle fails to invaginate. Dysgenesis of the vesicle later in development may result in coloboma, a separate and less severe malformation of the ocular structures.
CCE is almost always unilateral, but at least 2 cases of bilateral involvement have been described. Patients may also present with skin appendages attached to the skin surrounding the eyes. Association with intracranial anomalies has been reported.
Treatment
Treatment of CCE is usually by enucleation, followed by insertion of an ocular implant and prosthesis.
References
External links
Congenital disorders of eyes |
https://en.wikipedia.org/wiki/Western%20Cape%20wine | Western Cape is a Geographical Unit within the Wine of Origin classification system of South African wine. Corresponding to the province of Western Cape it includes most of the vineyards in South Africa.
Style
The wines of the Western Cape range from sturdy Rhone-style red wines to aromatic Sauvignon blancs in vineyards cooled by breezes off the Atlantic.
History
On 2 February 1659 the founder of Cape Town, Jan van Riebeeck, produced the first wine recorded in South Africa. In 1685, the Constantia estate was established in a valley facing False Bay by the Governor of the Cape, Simon van der Stel. His 'Vin de Constance' soon acquired a good reputation. But it was Hendrik Cloete, who bought the homestead in 1778, who really made the name of Constantia famous, with an unfortified wine made from a blend of mostly Muscat de Frontignan (Muscat Blanc à Petits Grains), Pontiac, red and white Muscadel (probably clones of Muscat Blanc à Petits Grains??) and a little Chenin blanc. It became a favorite tipple of European kings and emperors, from Frederick the Great to Napoleon. But the vineyards were decimated by phylloxera, the Cloete family were bankrupted, and Groot Constantia was sold to the government as an experimental station. In 1980 Duggie Jooste bought Klein Constantia, redeveloped it, and is now selling a new version of Vin de Constance made from Muscat Blanc à Petits Grains.
The Franschhoek Valley was settled over 300 years ago by the French Huguenots. The first official |
https://en.wikipedia.org/wiki/KwaZulu-Natal%20wine | KwaZulu-Natal is designated as a geographical unit under the Wine of Origin classification of South African wine. It corresponds to the province of KwaZulu-Natal in the east of South Africa, which has an embryonic wine industry.
History
The first trials of Vitis vinifera in KwaZulu-Natal were in 1992 at Sunwich Port on the South Coast.
Tiny and Judy van Niekerk established the Stables Wine Estate in 2005, the first wine estate in KwaZulu-Natal, and released the first wines from the region in 2006. Judy van Niekerk was responsible for having KZN designated as a "Wine of Origin" region in 2005 after negotiations with SAWIS.
Owners and winemakers Ian and Jane Smorthwaite bought their farm Abingdon Wine Estate in 2000 and the first vines were planted in 2004. Situated at 1100m above sea level, Abingdon Estate has in excess of 2ha under vine.
Judy van Niekerk approached the KZN Government in 2007 with a proposal to fund vineyard plantings in the Tribal regions of the province, creating job opportunities in under-resourced regions. This project commenced in 2009 with newer plantings of 10ha at Ballito on the KNZ north coast. These vineyards are cultivating the French-American hybrid Villard Blanc, a grape cultivar that thrives in warm, humid conditions. The first wines of this were produced in Sept 2013 under the banner of iLembe Co-operative Winery.
See also
South African wine
Wine regions of South Africa
Notes and references
Further reading
John Platter South African W |
https://en.wikipedia.org/wiki/State%20Statistics%20Service%20of%20Ukraine | State Statistics Committee of Ukraine (, Derzhavnyi Komitet Statystyky Ukrainy) is the government agency responsible for collection and dissemination of statistics in Ukraine. For brevity, it was also referred to as Derzhkomstat. In 2010, the committee was transformed into the State Service of Statistics under the Ministry of Economic Development and Trade.
Institutions
Science and Research Institute of Statistics, keeps track of the Classification of objects of the administrative-territorial system of Ukraine
See also
Ukrainian Census (2001), Censuses in Ukraine
External links
Official website (Ukrainian, Russian, English)
2001 Ukraine Census
Presidential decree #1085/2010 "For optimization the system of central bodies of executive power (Ukrainian)
Statistics
Ukraine
Ministry of Economic Development, Trade and Agriculture
Central executive bodies of Ukraine |
https://en.wikipedia.org/wiki/Number%20sentence | In mathematics education, a number sentence is an equation or inequality expressed using numbers and mathematical symbols. The term is used in primary level mathematics teaching in the US, Canada, UK, Australia, New Zealand and South Africa.
Usage
The term is used as means of asking students to write down equations using simple mathematical symbols (numerals, the four main basic mathematical operators, equality symbol). Sometimes boxes or shapes are used to indicate unknown values. As such, number sentences are used to introduce students to notions of structure and elementary algebra prior to a more formal treatment of these concepts.
A number sentence without unknowns is equivalent to a logical proposition expressed using the notation of arithmetic.
Examples
A valid number sentence that is true: 83 + 19 = 102.
A valid number sentence that is false: 1 + 1 = 3.
A valid number sentence using a 'less than' symbol: 3 + 6 < 10.
A valid number sentence using a 'more than' symbol: 3 + 9 > 11.
An example from a lesson plan:
Some students will use a direct computational approach. They will carry out the addition 26 + 39 = 65, put 65 = 26 + , and then find that = 39.
See also
Expression (mathematics)
Equation
Inequality (mathematics)
Open sentence
Sentence (mathematical logic)
References
Mathematics education |
https://en.wikipedia.org/wiki/2%2C5-Dimethylfuran | 2,5-Dimethylfuran is a heterocyclic compound with the formula (CH3)2C4H2O. Although often abbreviated DMF, it should not be confused with dimethylformamide. A derivative of furan, this simple compound is a potential biofuel, being derivable from cellulose.
Production
Fructose can be converted into 2,5-dimethylfuran in a catalytic biomass-to-liquid process. The conversion of fructose to DMF proceeds via hydroxymethylfurfural.
Fructose is obtainable from glucose, a building block in cellulose.
Potential as a biofuel
DMF has a number of attractions as a biofuel. It has an energy density 40% greater than that of ethanol, making it comparable to gasoline (petrol). It is also chemically stable and, being insoluble in water, does not absorb moisture from the atmosphere. Evaporating dimethylfuran during the production process also requires around one third less energy than the evaporation of ethanol, although it has a boiling point some 14 °C higher, at 92 °C, compared to 78 °C for ethanol.
The ability to efficiently and rapidly produce dimethylfuran from fructose, found in fruit and some root vegetables, or from glucose, which can be derived from starch and cellulose - all widely available in nature - adds to the attraction of dimethylfuran, although safety issues must be examined. Bioethanol and biodiesel are currently the leading liquid biofuels.
The stoichiometric air/fuel ratio of dimethylfuran is 10.72, compared to ethanol at 8.95 and gasoline at 14.56. This means that bu |
https://en.wikipedia.org/wiki/Dichloromethane%20dehalogenase | Dichloromethane dehalogenase (EC 4.5.1.3; systematic name dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)) is a lyase enzyme that generates formaldehyde.
dichloromethane + H2O = formaldehyde + 2 chloride
Glutathione is required for its activity.
References
External links
EC 4.5 |
https://en.wikipedia.org/wiki/Steve%20Lovell%20%28Welsh%20footballer%29 | Stephen Lovell (born 16 July 1960) is a Welsh former professional footballer and manager. He is currently manager of Herne Bay.
He played professionally for Crystal Palace, Stockport County, Millwall, Swansea City, Gillingham and AFC Bournemouth and made over 450 Football League appearances. He was capped six times by Wales.
Playing career
Born in Swansea, Wales, Lovell began his career as an apprentice with Crystal Palace in 1977, winning the FA Youth Cup with the South London side in 1977 and 1978, before making his league debut in a 2–0 defeat away to Wolverhampton Wanderers on 30 August 1980. Playing at the time as a right-back or a midfielder, he managed 74 Football League appearances in six years at Selhurst Park, during which he also had spells on loan at Stockport County and with Memphis Rogues of the North American Soccer League. In 1983, he moved to Millwall, making his debut in a 5–1 defeat loss away to Huddersfield Town on 12 February 1983. Millwall manager George Graham played Lovell as a striker during an injury crisis and he went on to score 13 goals in 11 matches and remained a striker for the remainder of his career.
In 1986 Lovell was injured whilst playing for Wales and was unable to regain a place in the Millwall team and, after a short loan spell with his hometown club Swansea City, was sold to Gillingham for £20,000. During his time with the Kent club he played over 200 matches and scored nearly 100 goals, finishing as the club's leading scorer in fou |
https://en.wikipedia.org/wiki/PC3 | PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing their response to chemotherapeutic agents. PC3 cells are also used to study viral infection in mammalian cells that exhibit an immune response
Description
The PC3 cell line was established in 1979 from bone metastasis of grade IV of prostate cancer in a 62-year-old Caucasian male. These cells do not respond to androgens, glucocorticoids or fibroblast growth factors, but results suggest that the cells are influenced by epidermal growth factors. PC3 cells can be used to create subcutaneous tumor xenografts in mice to investigate the tumor environment and therapeutic drug functionality.
PC3 cells have high metastatic potential compared to DU145 cells, which have a moderate metastatic potential, and to LNCaP cells, which have low metastatic potential. Comparisons of the protein expression of PC3, LNCaP, and other cells have shown that PC3 is characteristic of small cell neoendocrine carcinoma.
PC3 cells have low testosterone-5-alpha reductase and acidic phosphatase activity, and do not express PSA (prostate-specific antigen). Furthermore, karyotypic analysis has shown that PC3 are near-triploid, having 62 chromosomes. Q-band analysis showed no Y chromosome. From a morphological point of view, electron microscopy revealed that PC3 cells show characteristics of a poorly |
https://en.wikipedia.org/wiki/DU145 | DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research.
The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy of a 69-year-old, White, male. DU145 are not hormone-sensitive and do not express prostate-specific antigen (PSA). DU145 cells have moderate metastatic potential compared to PC3 cells, which have high metastatic potential.
Research on castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) is prostate cancer that progresses despite extremely low testosterone in the body often due to medical castration. Unlike many other types of prostate cancer, CRPC do not need normal testosterone levels, but they still require regular androgen receptors (AR).
Effects of NEK6 alteration
NEK6 inhibition is a potential treatment for CRPC due to its role as an essential protein kinase in the mitotic cell cycle. Although specific pathways remain unclear, deactivating the NEK6 gene is able to decrease clonogenic capacity, proliferation, cell viability, and mitochondrial activity. Additionally, intracellular ROS is increased and antioxidant defenses including SOD1, SOD2, and PRDX3 are decreased. SOD1, SOD2, and PRDX3 are known to be pro-oncogenic and be involved in chemotherapy resistance. Overall, altering NEK6 leads to DNA damage and death of |
https://en.wikipedia.org/wiki/Translocated%20promoter%20region | Translocated promoter region is a component of the tpr-met fusion protein.
External links |
https://en.wikipedia.org/wiki/Tpr-met%20fusion%20protein | Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET.
Structure
Tpr-Met was generated following a chromosomal rearrangement induced by the treatment of a human osteogenic sarcoma cell line with the carcinogen N-methyl-N'-nitronitrosoguanidine. The genomic rearrangement fuses two genetic loci, translocated promoter region, from chromosome 1q25 which encodes a dimerization leucine zipper motif, and MET, from chromosome 7q31 which contributes the kinase domain and carboxy-terminus of the Met RTK. The resulting 65 kDa cytoplasmic Tpr-Met oncoprotein forms a dimer mediated through the Tpr leucine zipper.
The Tpr-Met fusion protein lacks the extracellular, transmembrane and juxtamembrane domains of c-Met receptor, and has gained the Tpr dimerization motif, which allows constitutive and ligand-independent activation of the kinase. The loss of juxtamembrane sequences, necessary for the negative regulation of kinase activity and receptor degradation, prolongs duration of Met signalling.
Experimental evidences
Effects in muscle
Skeletal muscle
Specific expression of Tpr-Met in terminally-differentiated skeletal muscle causes muscle wasting in vivo and exerts anti-differentiation effects in terminally differentiated myotubes. Constitutive activation of MET signaling has been suggested to cause defects in myogenic differentiation, contributing to rhabdomyosarcoma development and progression.
Cardiac muscle
In a transgenic model, cardiac-specific express |
https://en.wikipedia.org/wiki/Hfq%20protein | The Hfq protein (also known as HF-I protein) encoded by the hfq gene was discovered in 1968 as an Escherichia coli host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RNA binding protein which has many important physiological roles that are usually mediated by interacting with Hfq binding sRNA.
In E. coli, Hfq mutants show multiple stress response related phenotypes. The Hfq protein is now known to regulate the translation of two major stress transcription factors ( σS (RpoS) and σE (RpoE) ) in Enterobacteria. It also regulates sRNA in Vibrio cholerae, a specific example being MicX sRNA.
In Salmonella typhimurium, Hfq has been shown to be an essential virulence factor as its deletion attenuates the ability of S.typhimurium to invade epithelial cells, secrete virulence factors or survive in cultured macrophages. In Salmonella, Hfq deletion mutants are also non motile and exhibit chronic activation of the sigma mediated envelope stress response. A CLIP-Seq study of Hfq in Salmonella has revealed 640 binding sites across the Salmonella transcriptome. The majority of these binding sites was found in mRNAs and sRNAs.
In Photorhabdus luminescens, a deletion of the hfq gene causes loss of secondary metabolite production.
Hfq mediates its pleiotropic effects through several mechanisms. It interacts with regulatory sRNA and facilitates their antisense interaction with their targets. It also acts independently to m |
https://en.wikipedia.org/wiki/CD4%20immunoadhesin | CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region, similarly known as immunoglobulin. It belongs to the antibody (Ig) gene family. CD4 is a surface receptor for human immunodeficiency virus (HIV). The CD4 immunoadhesin molecular fusion allow the protein to possess key functions from each independent subunit. The CD4 specific properties include the gp120-binding and HIV-blocking capabilities. Properties specific to immunoglobulin are the long plasma half-life and Fc receptor binding. The properties of the protein means that it has potential to be used in AIDS therapy as of 2017. Specifically, CD4 immunoadhesin plays a role in antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells. While natural anti-gp120 antibodies exhibit a response towards uninfected CD4-expressing cells that have a soluble gp120 bound to the CD4 on the cell surface, CD4 immunoadhesin, however, will not exhibit a response. One of the most relevant of these possibilities is its ability to cross the placenta.
History and significance
CD4 immunoadhesin was first developed in the mid-1990s as a potential therapeutic agent and treatment for HIV/AIDS. The protein is a fusion of the extracellular domain of the CD4 receptor and the Fc domain of human immunoglobulin G (IgG), the most abundant antibody isotype in the human body. The Fc domain of IgG contributes several important properties to the fusion protein, inclu |
https://en.wikipedia.org/wiki/Heparin-binding%20EGF-like%20growth%20factor | Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.
HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
Interactions
Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1.
HB-EGF biological activities with these genes influence cell cycle progression, molecular chaperone regulation, |
https://en.wikipedia.org/wiki/Extensin | Extensins are a family of flexuous, rodlike, hydroxyproline-rich glycoproteins (HRGPs) of the plant cell wall.
They are highly abundant proteins. There are around 20 extensins in Arabidopsis thaliana. They form crosslinked networks in the young cell wall. Typically they have two major diagnostic repetitive peptide motifs, one hydrophilic and the other hydrophobic, with potential for crosslinking. Extensins are thought to act as self-assembling amphiphiles essential for cell-wall assembly and growth by cell extension and expansion. The name "extensin" encapsulates the hypothesis that they are involved in cell extension.
Hydrophilic motif
This pentapeptide consists of serine (Ser) and four hydroxyprolines (Hyp): Ser-Hyp-Hyp-Hyp-Hyp. Hydroxyproline is unusual not only as a cyclic amino acid that restricts peptide flexibility but as an amino acid with no codon, being encoded as proline. Polypeptides targeted for secretion are subsequently hydroxylated by direct addition of molecular oxygen to proline at C-4. Extensin hydroxyproline is uniquely glycosylated with short chains of L-arabinose that further rigidify and increase hydrophilicity. Generally the serine has a single galactose attached.
Hydrophobic tyrosine crosslinking motif
Two tyrosines separated by a single amino acid, typically valine or another tyrosine, form a short intra-molecular diphenylether crosslink. This can be crosslinked further by the enzyme extensin peroxidase to form an inter-molecular bridge between e |
https://en.wikipedia.org/wiki/Biometrics%20%28journal%29 | Biometrics is a journal that publishes articles on the application of statistics and mathematics to the biological sciences. It is published by the International Biometric Society (IBS). Originally published in 1945 under the title Biometrics Bulletin, the journal adopted the shorter title in 1947. A notable contributor to the journal was R.A. Fisher, for whom a memorial edition was published in 1964. In a survey of statistics researchers' opinions, it was ranked fifth overall among 40 statistics journals, and it was second only to the Journal of the American Statistical Association in the ranking provided by biometrics specialists.
References
External links
Publisher website (Wiley)
International Biometric Society (IBS)
Biometry by m2sys.com
Biostatistics journals
Academic journals established in 1945
Wiley-Blackwell academic journals
English-language journals
Quarterly journals
Academic journals associated with international learned and professional societies |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.