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10.1002/smtd.202101254 | 132,915,084 | Abstract The global threat of antibiotic resistance underscores critical but unmet needs for rapid antibiotic susceptibility testing (AST) technologies. To this end, droplet microfluidic‐based single‐cell AST offers promise by achieving unprecedented rapidity, but its potential for clinical use is marred by the capacit... | 10.1038/s43586-022-00190-y | This study demonstrates a droplet device for rapid and multiplex phenotypic AST |
10.1126/scitranslmed.aal3693 | 122,496,644 | Rapid antimicrobial susceptibility testing (AST) is urgently needed for informing treatment decisions and preventing the spread of antimicrobial resistance resulting from the misuse and overuse of antibiotics. To date, no phenotypic AST exists that can be performed within a single patient visit (30 min) directly from c... | 10.1038/s43586-022-00190-y | This study demonstrates a digital LAMP quantification method, which quantifies bacterial growth with high sensitivity for rapid phenotypic AST |
10.1038/s41467-020-20230-z | 62,025,946 | Abstract In vivo mutagenesis systems accelerate directed protein evolution but often show restricted capabilities and deleterious off-site mutations on cells. To overcome these limitations, here we report an in vivo platform to diversify specific DNA segments based on protein fusions between various base deaminases (BD... | 10.1038/s43586-022-00119-5 | This work expands the MutaT7 technology through the fusion of new base deaminases to T7RNAP (thereby achieving targeted hypermutation with expanded mutational parameters in E. coli ) and the addition of dCas9 to terminate polymerization by T7RNAP (thereby providing more control over the window of hypermutation) |
10.1093/nar/gkaa1231 | 17,175,687 | Abstract Various in vivo mutagenesis methods have been developed to facilitate fast and efficient continuous evolution of proteins in cells. However, they either modify the DNA region that does not match the target gene, or suffer from low mutation rates. Here, we report a mutator, eMutaT7 (enhanced MutaT7), with very ... | 10.1038/s43586-022-00119-5 | This work presents an expansion of MutaT7 technology to achieve exceptionally high rates of hypermutation in E. coli |
10.1038/s41467-021-21876-z | 14,307,140 | Abstract Random mutagenesis is a technique used to generate diversity and engineer biological systems. In vivo random mutagenesis generates diversity directly in a host organism, enabling applications such as lineage tracing, continuous evolution, and protein engineering. Here we describe TRIDENT (TaRgeted In vivo Dive... | 10.1038/s43586-022-00119-5 | This work extends the MutaT7 strategy to yeast, enabling the continuous targeted hypermutation and in vivo continuous evolution of GOIs in S. cerevisiae |
10.1038/s41467-020-19539-6 | 38,262,308 | Abstract Enzyme orthologs sharing identical primary functions can have different promiscuous activities. While it is possible to mine this natural diversity to obtain useful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of deep evolutionary processes occurring in a multi... | 10.1038/s43586-022-00119-5 | This work demonstrates the use of OrthoRep to evolve in a scalable manner a large collection of highly diverse orthologues of an enzyme (TrpB), which was mined for promiscuous activities leading to the biosynthesis of valuable chemicals |
10.1126/science.abb5916 | 62,451,643 | Removal of senescent cells (senolysis) has been proposed to be beneficial for improving age-associated pathologies, but the molecular pathways for such senolytic activity have not yet emerged. Here, we identified glutaminase 1 ( GLS1 ) as an essential gene for the survival of human senescent cells. The intracellular pH... | 10.1038/s43587-023-00369-2 | This paper reports that senescent cells rely on glutaminolysis, and its inhibition offers a promising strategy for inducing senolysis in vivo. |
10.1073/pnas.92.20.9363 | 62,247,869 | Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of aging. There is ample evidence that escape from senescence, or imm... | 10.1038/s43587-023-00369-2 | This paper reports that SA-β-gal is a useful marker of senescence. |
10.1002/gbc.20021 | 104,215,111 | Forests mediate the biogeochemical cycling of mercury (Hg) between the atmosphere and terrestrial ecosystems; however, there remain many gaps in our understanding of these processes. Our objectives in this study were to characterize Hg isotopic composition within forests, and use natural abundance stable Hg isotopes to... | 10.1038/s43017-021-00146-y | Demonstrates that dry deposition represents a major deposition pathway through the use of Hg stable isotopes |
10.5194/acp-16-4451-2016 | 104,215,106 | Abstract. Reliable quantification of air–surface fluxes of elemental Hg vapor (Hg0) is crucial for understanding mercury (Hg) global biogeochemical cycles. There have been extensive measurements and modeling efforts devoted to estimating the exchange fluxes between the atmosphere and various surfaces (e.g., soil, canop... | 10.1038/s43017-021-00146-y | Reviews the state of science in the atmosphere–surface exchange mechanisms, observation techniques and model parameterizations |
10.5194/acp-17-5271-2017 | 113,549,674 | Abstract. Current understanding of mercury (Hg) behavior in the atmosphere contains significant gaps. Some key characteristics of Hg processes, including anthropogenic and geogenic emissions, atmospheric chemistry, and air–surface exchange, are still poorly known. This study provides a complex analysis of processes gov... | 10.1038/s43017-021-00146-y | Reviews global Hg models and their differences, uncertainties and evaluation with measurements |
10.1182/blood-2021-146944 | 128,531,568 | Abstract Introduction: Translocations involving the MLL gene on chromosome 11q23 result in fusions with ≥10 partner genes that act as drivers in relatively chemotherapy resistant MLL-rearranged (MLLr) leukemias. These chimeric proteins form part of protein complexes that aberrantly upregulate transcription of the leuke... | 10.1038/s43018-022-00371-4 | This abstract from the American Society of Hematology Conference in 2021 demonstrates the preliminary efficacy of MENIN inhibitors in a phase 1 trial |
10.1073/pnas.1706054114 | 59,074,786 | Calcium influx through the voltage-dependent L-type calcium channel (Ca V 1.2) rapidly increases in the heart during “fight or flight” through activation of the β-adrenergic and protein kinase A (PKA) signaling pathway. The precise molecular mechanisms of β-adrenergic activation of cardiac Ca V 1.2, however, are incomp... | 10.1038/s44161-022-00168-9 | This paper demonstrates that PKA phosphorylation and proteolytic cleavage of the C terminus of the Ca V channel α 1C subunit are not required for adrenergic augmentation of calcium currents in the heart. |
10.1073/pnas.1116141109 | 40,509,513 | Pedestrian crowds can form the substrate of important socially contagious behaviors, including propagation of visual attention, violence, opinions, and emotional state. However, relating individual to collective behavior is often difficult, and quantitative studies have largely used laboratory experimentation. We prese... | 10.1038/s44159-022-00118-z | This study investigates gaze-following behaviours in real-life, crowded contexts and shows that behavioural contagion of gaze-following by passers-by plateaus at about 10–15 individuals showing consistent gaze |
10.1111/nyas.13854 | 39,778,637 | Abstract Social interactions are at the core of social life. However, humans selectively choose their exchange partners and do not engage in all available opportunities for social encounters. In this review, we argue that attentional systems play an important role in guiding the selection of social interactions. Suppor... | 10.1038/s44159-022-00118-z | This review shows that the attentional system interacts with three core processes — perception, interpretation and evaluation — to modulate selective responses to social environments |
10.1177/1745691620953773 | 109,201,208 | When two people look at the same object in the environment and are aware of each other’s attentional state, they find themselves in a shared-attention episode. This can occur through intentional or incidental signaling and, in either case, causes an exchange of information between the two parties about the environment ... | 10.1038/s44159-022-00118-z | This review integrates current knowledge about the building blocks of shared attention (gaze perception and joint attention) into a neurocognitive model (the shared-attention system) that encompasses the perceptual, cognitive and affective processes that are involved in shared-attention episodes |
10.1098/rspb.2016.0376 | 102,038,816 | Gaze following, or co-orienting with others, is a foundational skill for human social behaviour. The emergence of this capacity scaffolds critical human-specific abilities such as theory of mind and language. Non-human primates also follow others' gaze, but less is known about how the cognitive mechanisms supporting th... | 10.1038/s44159-022-00118-z | This study revealed that semi-free-ranging rhesus monkeys experience substantial ontogenetic changes in gaze-following, with striking similarities to gaze changes over the human lifespan |
10.1177/0956797614544510 | 102,198,517 | In nearly every interpersonal encounter, people readily gather socio-visual cues to guide their behavior. Intriguingly, social information is most effective in directing behavior when it is perceived in crowds. For example, the shared gaze of a crowd is more likely to direct attention than is a single person’s gaze. Ar... | 10.1038/s44159-022-00118-z | This study shows that humans form a summary representation of a crowd’s attention by rapidly pooling information from the attention of crowd members and combining information from head and pupil rotation |
10.1177/0956797619867295 | 61,474,704 | Humans can effectively search visual scenes by spatial location, visual feature, or whole object. Here, we showed that visual search can also benefit from fast appraisal of relations between individuals in human groups. Healthy adults searched for a facing (seemingly interacting) body dyad among nonfacing dyads or a no... | 10.1038/s44159-022-00118-z | This study shows that visual search in crowded contexts benefits from perceptual subgrouping of interacting (facing) dyads within a crowd |
10.1039/c9sc02347j | 74,207,769 | Multi-state photoswitchable compounds are highly attractive for application in data storage or multi-responsive materials. Herein, a trisazobenzene macrocycle is presented, which can be switched selectively into three individual states. | 10.1038/s42004-020-00438-2 | Reference 27 found that ring strain played a significant role in isomerization of photo-responsive macrocycles containing multiple azobenzene units, which would inspire the design of multi-state light-responsive materials. |
10.1002/chem.201404977 | 124,378,617 | Abstract New methodology for making novel materials is highly desirable. Here, an “ingredients” approach to functional self‐assembled hydrogels was developed. By designing a building block to contain the right ingredients, a multi‐responsive, self‐assembled hydrogel was obtained through a process of template‐induced se... | 10.1038/s42004-020-00438-2 | Reference 44 demonstrated that dynamic covalent disulfide chemistry could give rise to quantitative synthesis of a multi-responsive macrocycle, suggesting an efficient ring-closing reaction for responsive macrocycles. |
10.1126/science.aao1377 | 124,007,037 | Acid fuels the motion of a threaded ring A central goal in the construction of molecular-scale machines is the efficient achievement of one-way motion. Erbas-Cakmak et al. developed a class of machines that transmit pH changes into the two-stage guided motion of molecular rings threaded on a linear or cyclic axle. The ... | 10.1038/s42004-020-00438-2 | Reference 46 used chemical fuels to direct the movement of components and subtracts along ring and linear molecules, which not only revealed an energy ratchet mechanism for constructing molecular motors but also opened a new door for powering task performance in molecular nanotechnology. |
10.1038/s41467-022-31882-4 | 142,560,671 | Abstract Nanoparticle elasticity is crucial in nanoparticles’ physiological fate, but how this occurs is largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity (45 kPa – 760 MPa) as models, we isolate the effects of nanoparticle elasticity from those ... | 10.1038/s44222-023-00047-3 | This article reports that nanoparticle elasticity alters protein adsorption, modulating macrophage-mediated clearance of nanoparticles. |
10.1073/pnas.1911360117 | 15,142,938 | The impact of ultrasmall nanoparticles (<10-nm diameter) on the immune system is poorly understood. Recently, ultrasmall silica nanoparticles (USSN), which have gained increasing attention for therapeutic applications, were shown to stimulate T lymphocytes directly and at relatively low-exposure doses. Delineating u... | 10.1038/s44222-023-00047-3 | This article reports a T-cell-ligating nanoparticle with optimized size and surface charge. |
10.1126/science.1237572 | 102,951,301 | The generation of high-affinity antibodies depends on the ability of B cells to extract antigens from the surfaces of antigen-presenting cells. B cells that express high-affinity B cell receptors (BCRs) acquire more antigen and obtain better T cell help. However, the mechanisms by which B cells extract antigen remain u... | 10.1038/s44222-023-00047-3 | This article is the first to report that B cells selectively extract antigens by sensing the stiffness of a substrate. |
10.1038/s41467-020-20886-7 | 29,200,717 | Abstract Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant p... | 10.1038/s44222-023-00047-3 | This article reports that surface charge modulation in nanomaterial design regulates the intactness of serum proteins, affecting the systemic circulation of nanomedicines. |
10.1098/rspa.1964.0151 | 83,393,184 | The disintegration of drops in strong electric fields is believed to play an important part in the formation of thunderstorms, at least in those parts of them where no ice crystals are present. Zeleny showed experimentally that disintegration begins as a hydrodynamical instability, but his ideas about the mechanics of ... | 10.1038/s43586-023-00203-4 | Regarded as the first description of the physical processes causing electrospray. |
10.1002/mas.21551 | 83,187,709 | The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization‐based MS and MS/MS spectra in order to identify small‐molecule analytes (typically below 2000 Da). Most of what is disc... | 10.1038/s43586-023-00203-4 | A beginner’s guide for interpretation of an ESI mass spectrum. |
10.1146/annurev-environ-012220-010228 | 84,050,476 | Ongoing deforestation in the Brazilian Amazon is the outcome of an explicit federal project to occupy, integrate, and “modernize” the region. Although there have been isolated periods of deforestation control, most recently between 2004 and 2012, the overall trajectory of the region since the colonial period has been o... | 10.1038/s41893-022-00953-1 | A review article that identifies the trends and outcomes of deforestation and degradation in the Brazilian Amazon, highlighting the related development policies. |
10.1111/conl.12008 | 62,152,598 | Abstract The hydrological connectivity of freshwater ecosystems in the Amazon basin makes them highly sensitive to a broad range of anthropogenic activities occurring in aquatic and terrestrial systems at local and distant locations. Amazon freshwater ecosystems are suffering escalating impacts caused by expansions in ... | 10.1038/s41893-022-00953-1 | A review article that describes freshwater ecosystems in Amazonia, including the ecological services they provide, the drivers of degradation and management strategies to protect them. |
10.1126/science.aar4265 | 60,719,978 | It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore re... | 10.1038/s42254-021-00302-9 | An application of the CISS-induced exchange forces and the relevance of these forces to homochirality in life |
10.1126/science.1199339 | 83,309,492 | Photoelectrons emitted from a DNA-covered gold surface can have an unbalanced spin population of up to 60%. | 10.1038/s42254-021-00302-9 | A demonstration of high spin selectivity of photoexcited electrons passing through chiral monolayers |
10.1126/sciadv.aay0571 | 83,479,744 | Chiral-induced spin selectivity (CISS) occurs when the chirality of the transporting medium selects one of the two spin ½ states to transport through the media while blocking the other. Monolayers of chiral organic molecules demonstrate CISS but are limited in their efficiency and utility by the requirement of a monola... | 10.1038/s42254-021-00302-9 | Close to 90% spin selectivity achieved in chiral perovskites crystals |
10.2337/db13-1848 | 59,102,716 | The intrauterine environment during pregnancy is a critical factor in the development of diabetes and obesity in offspring. To determine the effects of maternal exercise during pregnancy on the metabolic health of offspring, 6-week-old C57BL/6 virgin female mice were fed a chow (21%) or high-fat (60%) diet and divided ... | 10.1038/s42255-020-00274-7 | This study investigated the best time for exercise training during pregnancy and shows that maternal exercise in mice before and during pregnancy improves metabolic health in male offspring |
10.2337/db17-0098 | 83,297,781 | Poor maternal diet can lead to metabolic disease in offspring, whereas maternal exercise may have beneficial effects on offspring health. In this study, we determined ifmaternal exercise could reverse the detrimental effects of maternal high-fat feeding on offspring metabolism of female mice. C57BL/6 female mice were f... | 10.1038/s42255-020-00274-7 | This study reveals that maternal exercise in mice improves systemic metabolism and liver function in female offspring |
10.2337/db13-1614 | 62,156,253 | Abnormal conditions during early development adversely affect later health. We investigated whether maternal exercise could protect offspring from adverse effects of a maternal high-fat diet (HFD) with a focus on the metabolic outcomes and epigenetic regulation of the metabolic master regulator, peroxisome proliferator... | 10.1038/s42255-020-00274-7 | This study shows that maternal exercise in mice prevents epigenetic alterations caused by maternal overnutrition in muscles in female offspring |
10.1152/ajpendo.00213.2012 | 101,121,756 | Emerging research has shown that subtle factors during pregnancy and gestation can influence long-term health in offspring. In an attempt to be proactive, we set out to explore whether a nonpharmacological intervention, perinatal exercise, might improve offspring health. Female mice were separated into sedentary or exe... | 10.1038/s42255-020-00274-7 | This article demonstrates that maternal exercise in mice increases insulin-stimulated glucose uptake in the soleus and adipose tissues in female offspring, thus improving their metabolic health |
10.1126/sciadv.aaz0359 | 124,296,511 | The obesity rate is rapidly increasing, which has been attributed to lack of exercise and excessive energy intake. Here, we found a previously unidentified explanation, due to lack of maternal exercise. In this study, healthy maternal mice were assigned either to a sedentary lifestyle or to exercise daily, and fetal br... | 10.1038/s42255-020-00274-7 | In this study, analysis of methylation changes in the Prdm16 promoter in adipose tissue indicates that maternal exercise in mice improves BAT and beige adipose tissue function, thus protecting offspring from obesity |
10.1126/science.aad7977 | 38,377,117 | Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse spe... | 10.1038/s42255-020-00274-7 | This article demonstrates that tsRNAs present in paternal sperm are capable of directing the metabolic programming of F 1 offspring, as a result of the dietary status of the F 0 fathers |
10.1152/ajpendo.00013.2015 | 125,168,100 | Obesity and type 2 diabetes are increasingly prevalent across all demographics. Paternal obesity in humans and rodents can program obesity and impair insulin sensitivity in female offspring. It remains to be determined whether these perturbed offspring phenotypes can be improved through targeted lifestyle interventions... | 10.1038/s42255-020-00274-7 | This study shows that exercise training in obese male mice normalizes the X-linked miRNA profile in sperm and increases insulin sensitivity in female offspring |
10.2337/db18-0667 | 100,587,364 | Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and alterations in sperm may be a major mechanism mediating these detrimental effects of diet. Although exercise in the general population is known to improve health, the effects of paternal exercise on sperm and offspring metabolic hea... | 10.1038/s42255-020-00274-7 | This article reveals that paternal exercise training normalizes the detrimental effects of a paternal high-fat diet on sperm motility, the sperm miRNA profile and glucose tolerance in offspring |
10.1063/1.2709758 | 20,699,205 | The technique of atom probe tomography (APT) is reviewed with an emphasis on illustrating what is possible with the technique both now and in the future. APT delivers the highest spatial resolution (sub-0.3-nm) three-dimensional compositional information of any microscopy technique. Recently, APT has changed dramatical... | 10.1038/s43586-021-00047-w | This article is a thorough introductory review article on APT, with an emphasis on its historical developments |
10.1038/s41598-020-77130-x | 105,309,550 | Abstract Measuring biological samples by atom probe tomography (APT) in their natural environment, i.e. aqueous solution, would take this analytical method, which is currently well established for metals, semi-conductive materials and non-metals, to a new level. It would give information about the 3D chemical structure... | 10.1038/s43586-021-00047-w | This article is a first thorough report on the analysis of thick layers of ice, liquid-metal interfaces and solutions |
10.1002/adem.201800255 | 60,050,174 | This review gives an overview of the effects of clusters in various aluminum alloys. Characterization methods are discussed in general and results for the important AlMgSi alloys are presented in detail. Indirect characterization methods, such as hardness, tensile testing, electrical resistivity, differential scanning ... | 10.1038/s43586-021-00047-w | This article reviews and compares cluster-finding techniques, therein applied to aluminium alloys |
10.1002/adfm.201801439 | 81,990,795 | Abstract The direct imaging of individual atoms within the cellular context holds great potential for understanding the fundamental physical and chemical processes in organisms. Here, a novel approach for imaging of electrically insulated biological cells by introducing a graphene encapsulation approach to “disguise” t... | 10.1038/s43586-021-00047-w | This article reports a new approach to enable the analysis of biological samples by APT, discussing aspects of what the technique can bring |
10.1146/annurev-fluid-122414-034252 | 61,414,298 | Pyroclastic density currents are generated in explosive volcanic eruptions when gas and particle mixtures remain denser than the surrounding atmosphere. These mobile currents have a diversity of flow regimes, from energetic granular flows to turbulent suspensions. Given their hazardous nature, much of our understanding... | 10.1038/s43017-020-0064-8 | A review of experimental, theoretical and computational work, with a focus on fluid-dynamic approaches, illustrating advances and current challenges in PDC research |
10.1029/2011jb009081 | 20,834,156 | The dynamics of the May 18, 1980 lateral blast at Mount St. Helens, Washington (USA), were studied by means of a three‐dimensional multiphase flow model. Numerical simulations describe the blast flow as a high‐velocity pyroclastic density current generated by a rapid expansion (burst phase, lasting less than 20 s) of a... | 10.1038/s43017-020-0064-8 | Three-dimensional, multiphase flow numerical models illuminate several aspects of PDC generation and emplacement, and inform interpretation of PDC deposits |
10.1002/2017jb013981 | 79,850,118 | Abstract A new depth‐averaged model has been developed for the simulation of both concentrated and dilute pyroclastic currents and their interactions. The capability of the model to reproduce a real event is tested for the first time with two well‐studied eruptive phases of the 2010 eruption of Merapi volcano (Indonesi... | 10.1038/s43017-020-0064-8 | Multilayer, depth-averaged models represent a promising computational approach to describe, in a simple way, the inner structure of PDCs, but still require calibration of the interaction between the concentrated and dilute layer |
10.1002/adma.202101473 | 135,058,582 | Abstract High‐entropy materials (HEMs) have great potential for energy storage and conversion due to their diverse compositions, and unexpected physical and chemical features. However, high‐entropy atomic layers with fully exposed active sites are difficult to synthesize since their phases are easily segregated. Here, ... | 10.1038/s43246-023-00341-y | Among the first papers on high-entropy 2D MXenes and the first on an M 2 CT x high-entropy MXene |
10.1002/adma.202100347 | 122,351,241 | Abstract High‐entropy alloys combine multiple principal elements at a near equal fraction to form vast compositional spaces to achieve outstanding functionalities that are absent in alloys with one or two principal elements. Here, the prediction, synthesis, and multiscale characterization of 2D high‐entropy transition ... | 10.1038/s43246-023-00341-y | Among the first reports on high-entropy 2D transition metal dichalogenides |
10.1111/agec.12454 | 20,881,698 | Abstract The purpose of this research was to explore how weather risk affects the value of nitrogen fertilizer use and improved seed variety adoption to sub‐Saharan African (SSA) maize farmers. It contributes to the literature by providing additional broad support for the hypothesis that low rates of fertilizer use and... | 10.1038/s43016-022-00494-y | This article models farmers’ willingness to pay for improved seeds and fertilizers in rainfed maize systems |
10.1126/science.abm0594 | 133,296,737 | Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al . designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR) T cells that can recognize the fibrotic cells in the heart (see the Perspective by Gao and Chen). By injecti... | 10.1038/s44161-022-00043-7 | In this paper, the authors used recent advances in lipid nanoparticle technology to engineer CAR T cells in vivo that effectively targeted FAP-expressing fibroblasts to diminish angiotensin II-induced cardiac injury in mice |
10.1073/pnas.1810301115 | 20,240,335 | Brazil has become a global leader in the production of commodity row crops such as soybean, sugarcane, cotton, and corn. Here, we report an increase in Brazilian cropland extent from 26.0 Mha in 2000 to 46.1 Mha in 2014. The states of Maranhão, Tocantins, Piauí, Bahia (collectively MATOPIBA), Mato Grosso, Mato Grosso d... | 10.1038/s41893-022-00969-7 | This paper reports on land-use changes in Brazil during the early twenty-first century. |
10.1007/s11625-020-00833-7 | 41,282,725 | Abstract The UN Sustainable Development Goals (SDGs) are a vision for achieving a sustainable future. Reliable, timely, comprehensive, and consistent data are critical for measuring progress towards, and ultimately achieving, the SDGs. Data from citizen science represent one new source of data that could be used for SD... | 10.1038/s43586-022-00144-4 | This is the first article to quantitatively assess the potential of citizen science for SDG indicator monitoring |
10.1098/rsos.202108 | 134,893,440 | Citizen science has expanded rapidly over the past decades. Yet, defining citizen science and its boundaries remained a challenge, and this is reflected in the literature—for example in the proliferation of typologies and definitions. There is a need for identifying areas of agreement and disagreement within the citize... | 10.1038/s43586-022-00144-4 | This article comprehensively explores the diverse perceptions of citizen science |
10.1007/s11625-021-00959-2 | 135,679,907 | Abstract Over the past decade, citizen science has experienced growth and popularity as a scientific practice and as a new form of stakeholder engagement and public participation in science or in the generation of new knowledge. One of the key requirements for realising the potential of citizen science is evidence and ... | 10.1038/s43586-022-00144-4 | This article presents guidelines for a common approach in assessing citizen science impacts |
10.1126/science.abi6487 | 135,443,831 | Does replacing the term “citizen science” do more harm than good? | 10.1038/s43586-022-00144-4 | This article discusses issues around justice, equity, diversity and inclusion related to citizen science |
10.1093/biosci/biab021 | 62,473,406 | Abstract Locally based monitoring is typically undertaken in areas in which communities have a close attachment to their natural resource base. We present a summary of work to develop a theoretical and practical understanding of locally based monitoring and we outline tests of this approach in research and practice ove... | 10.1038/s43586-022-00144-4 | This article summarizes the potential and intricacies of community-led citizen science |
10.1002/fee.1436 | 101,893,563 | Ecological and environmental citizen‐science projects have enormous potential to advance scientific knowledge, influence policy, and guide resource management by producing datasets that would otherwise be infeasible to generate. However, this potential can only be realized if the datasets are of high quality. While sci... | 10.1038/s43586-022-00144-4 | This article discusses common assumptions and evidence about citizen science data quality |
10.3389/fclim.2021.615032 | 2,365,928 | Information about data quality helps potential data users to determine whether and how data can be used and enables the analysis and interpretation of such data. Providing data quality information improves opportunities for data reuse by increasing the trustworthiness of the data. Recognizing the need for improving the... | 10.1038/s43586-022-00144-4 | This article describes perspectives on quality assessment and control issues |
10.1890/110294 | 20,703,522 | Citizen science creates a nexus between science and education that, when coupled with emerging technologies, expands the frontiers of ecological research and public engagement. Using representative technologies and other examples, we examine the future of citizen science in terms of its research processes, program and ... | 10.1038/s43586-022-00144-4 | This article gives a history account of the development of citizen science |
10.17161/bi.v17i.16441 | 135,062,456 | Citizen science has been in practice since the 1800s and is an important source of data for scientists and other applied users. It plays a vital role in democratizing science, providing equitable access to scientific participation and data, helps build the capacity of its participants, inculcates the spirit of scientif... | 10.1038/s43586-022-00144-4 | This document provides advice about the development of data management plans |
10.1093/biosci/biab018 | 45,409,762 | Abstract Effective responses to rapid environmental change rely on observations to inform planning and decision-making. Reviewing literature from 124 programs across the globe and analyzing survey data for 30 Arctic community-based monitoring programs, we compare top-down, large-scale program driven approaches with bot... | 10.1038/s43586-022-00144-4 | This article highlights the benefits of linking community- and science/policy-led approaches |
10.1084/jem.20150900 | 17,633,384 | Abnormal glucose metabolism and enhanced oxidative stress accelerate cardiovascular disease, a chronic inflammatory condition causing high morbidity and mortality. Here, we report that in monocytes and macrophages of patients with atherosclerotic coronary artery disease (CAD), overutilization of glucose promotes excess... | 10.1038/s44161-022-00103-y | An Article that describes the bias of CAD macrophages toward pro-inflammatory function |
10.1186/s12872-021-02137-9 | 135,384,198 | Abstract Background The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear. Methods We conducted a cohort study of consecutive adults hospitalised for severe COVID... | 10.1038/s44161-022-00103-y | A cohort study that examines the association between established cardiovascular disease and mortality in COVID-19. |
10.1111/gcb.12065 | 104,226,502 | Abstract Microbes play key roles in various biogeochemical processes, including carbon (C) and nitrogen (N) cycling. However, changes of microbial community at the functional gene level by livestock grazing, which is a global land‐use activity, remain unclear. Here we use a functional gene array, GeoChip 4.0, to examin... | 10.1038/s43017-022-00330-8 | This work shows that soil microbial community functional structure is very sensitive to livestock grazing |
10.1002/ece3.4099 | 40,868,323 | Abstract Quantifying the impact of climate change and human activities on grassland dynamics is an essential step for developing sustainable grassland ecosystem management strategies. However, the direction and magnitude of climate change and human activities in driving alpine grassland dynamic over the Tibetan Plateau... | 10.1038/s43017-022-00330-8 | This work finds that large inconsistencies exist in distinguishing the respective contribution of climatic and anthropogenic forces to grassland dynamics |
10.1111/gcb.12277 | 62,559,729 | Abstract With a pace of about twice the observed rate of global warming, the temperature on the Qinghai‐Tibetan Plateau (Earth's ‘third pole’) has increased by 0.2 °C per decade over the past 50 years, which results in significant permafrost thawing and glacier retreat. Our review suggested that warming enhanced net pr... | 10.1038/s43017-022-00330-8 | This work suggests that warming enhanced NPP and soil respiration but many uncertainties remain |
10.1890/11-1408.1 | 83,528,369 | Uncertainty about the effects of warming and grazing on soil nitrogen (N) availability, species composition, and aboveground net primary production (ANPP) limits our ability to predict how global carbon sequestration will vary under future warming with grazing in alpine regions. Through a controlled asymmetrical warmin... | 10.1038/s43017-022-00330-8 | This work shows the effects of asymmetric warming and moderate grazing on plant composition, diversity, productivity and their relationships |
10.1111/gcb.15786 | 128,866,606 | Abstract Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences b... | 10.1038/s43017-022-00330-8 | This work finds that the negative effect of warming on plant diversity disappears with experimental duration, and ambient climate modulates the effects of warming and grazing on productivity stability |
10.1073/pnas.1700299114 | 104,157,994 | The structure and function of alpine grassland ecosystems, including their extensive soil carbon stocks, are largely shaped by temperature. The Tibetan Plateau in particular has experienced significant warming over the past 50 y, and this warming trend is projected to intensify in the future. Such climate change will l... | 10.1038/s43017-022-00330-8 | This work demonstrates that shifting plant species composition in response to climate change may have stabilized primary production in this high-elevation ecosystem, but also causes a shift from above-ground to below-ground productivity |
10.1145/3422622 | 125,090,523 | Generative adversarial networks are a kind of artificial intelligence algorithm designed to solve the generative modeling problem. The goal of a generative model is to study a collection of training examples and learn the probability distribution that generated them. Generative Adversarial Networks (GANs) are then able... | 10.1038/s43586-022-00125-7 | This paper proposes a flexible PWL activation function for PWL-DNNs, and ReLU can be regarded as its special case, and analysis on the universal approximation ability and the relations to the shallow-architectured PWLNNs are given |
10.1126/science.1188761 | 102,222,159 | Perennial grains hold promise, especially for marginal landscapes or with limited resources where annual versions struggle. | 10.1038/s41893-022-01002-7 | This paper proposes the need to develop perennial grains to ensure food and ecosystem security. |
10.1073/pnas.0630531100 | 20,382,641 | Annual and perennial habit are two major strategies by which grasses adapt to seasonal environmental change, and these distinguish cultivated cereals from their wild relatives. Rhizomatousness, a key trait contributing to perenniality, was investigated by using an F 2 population from a cross between cultivated rice ( O... | 10.1038/s41893-022-01002-7 | This paper shows that it is possible to use O. longistaminata for the development of PR. |
10.1002/anie.201813523 | 18,959,083 | Abstract Palladium catalysis induced by visible light is an emerging field of catalysis. In contrast to classical reactions catalyzed by Pd complexes in the ground state, which mostly proceed through two‐electron redox processes, the mechanisms of these new methods based on photoexcited Pd complexes usually operate thr... | 10.1038/s44160-022-00086-5 | A review article offering an overview of visible-light-induced palladium photocatalysis |
10.1126/science.aau1777 | 20,044,910 | Single-electron reduction of a carbonyl to a ketyl enables access to a polarity-reversed platform of reactivity for this cornerstone functional group. However, the synthetic utility of the ketyl radical is hindered by the strong reductants necessary for its generation, which also limit its reactivity to net reductive m... | 10.1038/s44160-022-00086-5 | This paper reports the generation of ketyl-type radicals from α-oxy iodides under atom transfer catalysis |
10.1093/eurheartj/ehab724.1781 | 131,261,369 | Abstract Background More than half of hypertrophic cardiomyopathy (HCM) remains genetically unsolved. ALPK3 truncating variants (ALPK3tv) have been described as a cause of autosomal recessive cardiomyopathy in a small number of paediatric cases, but the pathogenicity in heterozygosity as a possible cause of autosomal d... | 10.1038/s44161-023-00221-1 | This article reported a cohort of patients carrying autosomal dominant ALPK3 truncating variants associated with adult-onset hypertrophic cardiomyopathy. |
10.1126/science.aal3321 | 104,257,315 | Mapping the proteome Proteins function in the context of their environment, so an understanding of cellular processes requires a knowledge of protein localization. Thul et al. used immunofluorescence microscopy to map 12,003 human proteins at a single-cell level into 30 cellular compartments and substructures (see the ... | 10.1038/s43586-021-00029-y | This ambitious work performs immunofluorescence and confocal microscopy to systematically assess the subcellular localization of more than 12,000 human proteins in several human cell lines, published in the HPA database |
10.1038/s41467-020-19840-4 | 107,221,199 | Abstract Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle rel... | 10.1038/s43586-021-00029-y | This article presents a general strategy for analysing intracellular sub-proteomes by combining acute cellular rewiring with high-resolution spatial proteomics |
10.1126/science.1230593 | 62,313,185 | Mitochondrial Makeup Mapped Because mass spectrometry (MS) cannot be performed on living cells, biologists currently recover spatial information indirectly, by purifying organelles or protein complexes prior to MS analysis. These purifications often yield false positives because of sample contamination and false negati... | 10.1038/s43586-021-00029-y | This article is the first example of combining APEX with MS, capturing spatial and temporal information for the human mitochondria matrix proteome, including 31 proteins not previously associated with this compartment |
10.1083/jcb.201112098 | 83,405,492 | We have developed a new technique for proximity-dependent labeling of proteins in eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is based on fusion of a promiscuous Escherichia coli biotin protein ligase to a targeting protein. BioID features proximity-dependent biotinylation... | 10.1038/s43586-021-00029-y | This article is the first description of BioID technology, identifying known and new components of the nuclear envelope using the well-characterized nuclear filament protein lamin A |
10.1126/science.aar7042 | 41,529,389 | Making multiplexed subcellular protein maps Being able to visualize protein localizations within cells and tissues by means of immuno-fluorescence microscopy has been key to developments in cell biology and beyond. Gut et al. present a high-throughput method that achieves the detection of more than 40 different protein... | 10.1038/s43586-021-00029-y | This work describes a protocol that achieves 40-plex protein staining in the same biological sample using off-the-shelf antibodies for immunofluorescence in an iterative manner |
10.1002/stem.736 | 4,716,381 | Abstract Embryonic stem cells (ESCs) derived from preimplantation blastocysts have unique self-renewal and multilineage differentiation properties that are controlled by key components of a core regulatory network including Oct4, Sox2, and Nanog. Understanding molecular underpinnings of these properties requires identi... | 10.1038/s43018-022-00425-7 | This article shows that Zfp281 is a repressor of Nanog , thereby allowing for differentiation programs during embryogenesis, and enables the understanding of Zfp281 function in early dissemination. |
10.1038/s41467-018-02838-4 | 123,078,583 | Abstract During the last century, inorganic oxide compounds laid foundations for materials synthesis, characterization, and technology translation by adding new functions into devices previously dominated by main-group element semiconductor compounds. Today, compounds with multiple anions beyond the single-oxide ion, s... | 10.1038/s44160-022-00132-2 | A review article that presents the implications of systems with multiple anions as candidates for catalysis, energy conversion and electronic materials. |
10.1073/pnas.1406211111 | 82,305,088 | Significance Dense inorganic materials comprise most functional electronic, optical, and magnetic devices. Whereas the discovery of new inorganic materials can increase our technical capabilities and uncover new phenomena, the search is difficult due to their formation at high temperatures where only the most stable (o... | 10.1038/s44160-022-00132-2 | This paper reports the powerful technique of panoramic synthesis in materials discovery using in situ X-ray diffraction. |
10.1126/science.aan3235 | 18,949,125 | 3D gene expression blueprint of the fly When looking at populations of cells, features such as cell heterogeneity and localization are masked. However, single-cell sequencing reveals cellular heterogeneity and rare cell types. At the onset of gastrulation, the fly embryo consists of about 6000 cells with distinct gene ... | 10.1038/s42003-020-01341-1 | DistMap employs quantitative Drop-seq methods to computationally reconstruct the Drosophila embryo using single-cell sequencing data |
10.1126/science.aaf2403 | 62,604,497 | Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the visualization of a few proteins or expressed genes at a time. We have devised a strategy, which we call “spatial transcriptomics,” that allows... | 10.1038/s42003-020-01341-1 | Spatial Transcriptomics is the pioneering approach using position-encoded barcodes combined with RNA-sequencing to retrieve gene expression with integrated spatial coordinates |
10.1126/science.aaw1219 | 20,831,748 | Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed Slide-seq, a method for transferring RNA from tissue sections onto a surface covered in DNA-barcoded beads with known positions, allowing the... | 10.1038/s42003-020-01341-1 | Slide-seq allows identification of cell zonation patterns and cellular constituents in single-cell tissues layers, using DNA-barcoding beads to release mRNA |
10.1038/s41467-019-11028-9 | 20,636,455 | Abstract Sequencing of newly synthesised RNA can monitor transcriptional dynamics with great sensitivity and high temporal resolution, but is currently restricted to populations of cells. Here, we develop new transcriptome alkylation-dependent single-cell RNA sequencing (NASC-seq), to monitor newly synthesised and pre-... | 10.1038/s42003-020-01341-1 | NASC-seq monitors newly synthesised and pre-existing RNAs simultaneously, providing single-cell, temporal analysis of the dynamic regulation of gene expression and RNA turnover |
10.3322/caac.21654 | 20,879,294 | Abstract Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program... | 10.1038/s41598-022-16155-w | (epub 2021 Jan 12. Erratum in: CA Cancer J Clin. 2021 Jul;71(4):359) |
10.1073/pnas.97.18.10101 | 62,382,892 | We describe the use of singular value decomposition in transforming genome-wide expression data from genes × arrays space to reduced diagonalized “eigengenes” × “eigenarrays” space, where the eigengenes (or eigenarrays) are unique orthonormal superpositions of the genes (or arrays). Normalizing the data by filtering ou... | 10.1038/s43586-022-00184-w | Application of PCA to gene expression data, proposing the concepts of eigenarrays and eigengenes as representative linear combinations of original arrays and genes. |
10.1126/science.aaa5648 | 103,178,650 | Yellowstone's missing magmatic link Yellowstone is an extensively studied “supervolcano” that has a large supply of heat coming from a pool of magma near the surface and the mantle below. A link between these two features has long been suspected. Huang et al. imaged the lower crust using seismic tomography (see the Per... | 10.1038/s43017-021-00191-7 | Using tomographic techniques, this paper presented the new discovery at Yellowstone (but now recognized at other centres globally) of the lower-crustal basaltic magma reservoir in addition to the previously known upper-crustal magma reservoir |
10.1002/anie.201410961 | 123,401,231 | Abstract One of the simplest methods for splitting water into H 2 and O 2 with solar energy entails the use of a particulate‐type semiconductor photocatalyst. To harness solar energy efficiently, a new water‐splitting photocatalyst that is active over a wider range of the visible spectrum has been developed. In particu... | 10.1038/s41929-019-0242-6 | The applicability of narrow band gap oxynitrides to one-step excitation overall water splitting is demonstrated via surface modifications with oxide thin layers. |
10.1002/2013jd020566 | 62,252,210 | Abstract Geoengineering with stratospheric sulfate aerosols has been proposed as a means of temporarily cooling the planet, alleviating some of the side effects of anthropogenic CO 2 emissions. However, one of the known side effects of stratospheric injections of sulfate aerosols under present‐day conditions is a gener... | 10.1038/s43017-019-0004-7 | One of the few papers to carry out an in-depth analysis of model differences, instead of focusing on similarities |
10.1002/2016ef000418 | 114,205,014 | Abstract Any well‐informed future decision on whether and how to deploy solar geoengineering requires balancing the impacts (both intended and unintended) of intervening in the climate against the impacts of not doing so. Despite tremendous progress in the last decade, the current state of knowledge remains insufficien... | 10.1038/s43017-019-0004-7 | Provides a state of the science from a field that was largely curiosity driven, providing motivation for moving to a mission-driven approach |
10.1029/2019jd031093 | 107,386,222 | Abstract Geoengineering methods could potentially offset aspects of greenhouse gas‐driven climate change. However, before embarking on any such strategy, a comprehensive understanding of its impacts must be obtained. Here, a 20‐member ensemble of simulations with the Community Earth System Model with the Whole Atmosphe... | 10.1038/s43017-019-0004-7 | One of the first studies to isolate some of the surface-climate effects of stratospheric heating |
10.5194/acp-17-3879-2017 | 107,386,373 | Abstract. Sulfate geoengineering has been proposed as an affordable and climate-effective means to temporarily offset the warming produced by the increase of well-mixed greenhouse gases (WMGHGs). This technique would likely have to be applied while and after global intergovernmental measures on emissions of WMGHGs are ... | 10.1038/s43017-019-0004-7 | Provides a multi-model summary of SAG from the lens of solar geoengineering as a design problem |
10.1029/2019jd030329 | 107,386,564 | Abstract Geoengineering with stratospheric sulfate aerosols can, to some extent, be designed to achieve different climate objectives. Here we use the state‐of‐the‐art Community Earth System Model, version 1, with the Whole Atmosphere Community Climate Model as its atmospheric component (CESM1(WACCM)), to compare surfac... | 10.1038/s43017-019-0004-7 | Illustrates the dependence of uncertainty on the SAG scenario and strategy |
10.1038/srep37254 | 82,288,749 | Abstract Current technologies for X-ray detection rely on scintillation from expensive inorganic crystals grown at high-temperature, which so far has hindered the development of large-area scintillator arrays. Thanks to the presence of heavy atoms, solution-grown hybrid lead halide perovskite single crystals exhibit sh... | 10.1038/s43246-023-00348-5 | The breakthrough report on the development of perovskites-based X-ray scintillators. |
10.1063/5.0093606 | 129,857,621 | Fast hybrid organic–inorganic two-dimensional (2D) perovskite scintillators with high light yield are measured for their scintillating properties. With a light yield of 17 300 ± 2140 photons/MeV, undoped PEA 2 PbBr 4 crystals already exhibit 100 ± 4 ps coincidence time resolution (CTR) at 511 keV excitation. However, L... | 10.1038/s43246-023-00348-5 | The impact of lithium dopant to improve the coincidence time resolution of hybrid perovskite scintillators from 100 to 84 ps. |
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