source_doi stringlengths 13 57 | source_mag_paper_id int64 490k 157M | source_abstract stringlengths 8 10.7k | target_doi stringlengths 14 27 | target_summary stringlengths 42 889 |
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10.1063/1.4812323 | 20,885,801 | Accelerating the discovery of advanced materials is essential for human welfare and sustainable, clean energy. In this paper, we introduce the Materials Project (www.materialsproject.org), a core program of the Materials Genome Initiative that uses high-throughput computing to uncover the properties of all known inorga... | 10.1038/s42256-020-0156-7 | This work presented the core programme of the Materials Genome Initiative that uses high-throughput computing to discover the properties of all known inorganic materials |
10.1126/science.aat7679 | 104,396,743 | The crystallization problem is an outstanding challenge in the chemistry of porous covalent organic frameworks (COFs). Their structural characterization has been limited to modeling and solutions based on powder x-ray or electron diffraction data. Single crystals of COFs amenable to x-ray diffraction characterization h... | 10.1038/s42004-018-0098-8 | Single crystal x-ray study of COF-300, providing deeper structural insight than previously attained |
10.1038/s41467-020-16640-8 | 83,186,289 | Abstract Nanoelectronic devices based on 2D materials are far from delivering their full theoretical performance potential due to the lack of scalable insulators. Amorphous oxides that work well in silicon technology have ill-defined interfaces with 2D materials and numerous defects, while 2D hexagonal boron nitride do... | 10.1038/s41928-022-00769-z | A review article that discusses the challenges of finding suitable gate insulators |
10.1126/sciadv.aav7266 | 41,582,820 | Himalayan glaciers supply meltwater to densely populated catchments in South Asia, and regional observations of glacier change over multiple decades are needed to understand climate drivers and assess resulting impacts on glacier-fed rivers. Here, we quantify changes in ice thickness during the intervals 1975–2000 and ... | 10.1038/s43017-020-00124-w | Identified and quantified accelerated glacier mass losses over the recent decades from 1975 to 2016 |
10.1126/science.aat4981 | 18,913,916 | Himalayan rivers are frequently hit by catastrophic floods that are caused by the failure of glacial lake and landslide dams; however, the dynamics and long-term impacts of such floods remain poorly understood. We present a comprehensive set of observations that capture the July 2016 glacial lake outburst flood (GLOF) ... | 10.1038/s43017-020-00124-w | Quantified the role of GLOFs in fluvial erosion and geomorphological evolution using in situ observations |
10.1002/smll.201000345 | 124,717,379 | Abstract The application of nanoscale electrical and biological devices will benefit from the development of nanomanufacturing technologies that are high‐throughput, low‐cost, and flexible. Utilizing nanomaterials as building blocks and organizing them in a rational way constitutes an attractive approach towards this g... | 10.1038/s41928-022-00802-1 | This article reports parallel near-field optical nanoprocessing using a microsphere array. |
10.1038/s41467-019-10508-2 | 19,718,121 | Abstract Somatic ribosomal protein mutations have recently been described in cancer, yet their impact on cellular transcription and translation remains poorly understood. Here, we integrate mRNA sequencing, ribosome footprinting, polysomal RNA sequencing and mass spectrometry datasets from a mouse lymphoid cell model t... | 10.1038/s42255-020-00329-9 | This paper highlights translational regulation of de novo serine and glycine synthesis |
10.1088/1742-6596/1858/1/012013 | 42,450,381 | Abstract Wastewater treatment using various existing technologies, including advanced oxidation processes, adsorption, and membrane separation for various pollutants removal from industrial and municipal wastewater streams, is an essential aspect of reaching environmental sustainability to keep human well-being and hea... | 10.1038/s42004-022-00744-x | Artificial intelligence can help predict and minimize complications and optimize wastewater treatment system parameters and processes. This study explains how artificial intelligence can help predict and minimize complications |
10.1126/sciadv.aaq0066 | 62,617,324 | Subnanometer metal organic framework pores can selectively transport alkali metal ions of the same valence and similar sizes. | 10.1038/s42004-022-00744-x | Researchers have shown that monovalent ions can be transported ultrafast and selectively through subnanometer MOF pores and have opened up new avenues for the development of future MOF platforms for ion separation |
10.1175/bams-d-19-0183.1 | 75,879,746 | Abstract Water management and flood control are major challenges in the western United States. They are heavily influenced by atmospheric river (AR) storms that produce both beneficial water supply and hazards; for example, 84% of all flood damages in the West (up to 99% in key areas) are associated with ARs. However, ... | 10.1038/s43247-020-00042-1 | This paper provides an overview of Atmospheric River Reconnaissance in the northeast Pacific which is key to the ideas proposed for AR Recon Atlantic |
10.1071/mf99078 | 19,080,395 | Sea temperatures in many tropical regions have increased by almost 1°C over the past 100 years, and are currently increasing at ~1–2°C per century. Coral bleaching occurs when the thermal tolerance of corals and their photosynthetic symbionts (zooxanthellae) is exceeded. Mass coral bleaching has occurred in association... | 10.1038/s43017-021-00214-3 | This paper projects loss and degradation of coral reefs on a global scale before it became common knowledge |
10.1073/pnas.2022653118 | 103,794,289 | Recurrent mass bleaching events are pushing coral reefs worldwide to the brink of ecological collapse. While the symptoms and consequences of this breakdown of the coral–algal symbiosis have been extensively characterized, our understanding of the underlying causes remains incomplete. Here, we investigated the nutrient... | 10.1038/s43017-021-00214-3 | This paper demonstrates that algal symbionts cease photosynthate transfer to coral hosts under heat stress long before visual signs of bleaching (symbiont loss) become evident |
10.1111/gcb.15148 | 82,855,418 | Abstract Coral bleaching is one of the main drivers of reef degradation. Most corals bleach and suffer mortality at just 1–2°C above their maximum monthly mean temperatures, but some species and genotypes resist or recover better than others. Here, we conducted a series of 18‐hr short‐term acute heat stress assays side... | 10.1038/s43017-021-00214-3 | This paper highlights the potential of mobile acute heat stress assays to resolve fine-scale differences in coral thermotolerance, suitable for large-scale identification of resilient genotypes/reefs for conservation and restoration approaches |
10.1002/bies.202000004 | 62,109,651 | Abstract Animals and plants are metaorganisms and associate with microbes that affect their physiology, stress tolerance, and fitness. Here the hypothesis that alteration of the microbiome may constitute a fast‐response mechanism to environmental change is examined. This is supported by recent reciprocal transplant exp... | 10.1038/s43017-021-00214-3 | This paper proposes microbiome flexibility as a mechanism to aid adaptation to environmental change and posits that capacity for dynamic restructuring of the microbiome is host specific |
10.1038/ncomms14213 | 20,845,221 | Abstract Ocean warming threatens corals and the coral reef ecosystem. Nevertheless, corals can be adapted to their thermal environment and inherit heat tolerance across generations. In addition, the diverse microbes that associate with corals have the capacity for more rapid change, potentially aiding the adaptation of... | 10.1038/s43017-021-00214-3 | This paper provides the first putative link between bacterial community composition and coral heat tolerance |
10.1146/annurev-animal-090120-115444 | 104,361,308 | The use of Beneficial Microorganisms for Corals (BMCs) has been proposed recently as a tool for the improvement of coral health, with knowledge in this research topic advancing rapidly. BMCs are defined as consortia of microorganisms that contribute to coral health through mechanisms that include ( a) promoting coral n... | 10.1038/s43017-021-00214-3 | This paper reviews coral probiotics and critical assessment of applicability |
10.1126/science.1251336 | 103,810,745 | Reef corals are highly sensitive to heat, yet populations resistant to climate change have recently been identified. To determine the mechanisms of temperature tolerance, we reciprocally transplanted corals between reef sites experiencing distinct temperature regimes and tested subsequent physiological and gene express... | 10.1038/s43017-021-00214-3 | This paper demonstrates that acclimation and adaptation contribute to coral thermal tolerance and climate resistance at about equal contribution |
10.1126/science.1261224 | 123,195,351 | Some like it hot Coral reefs are threatened by increasing temperatures. Acute temperature increases stress and damage corals. However, more gradual temperature changes can result in adaptation and subsequent tolerance for higher temperatures. Dixon et al. show that the heat tolerance that currently exists across coral ... | 10.1038/s43017-021-00214-3 | This paper demonstrates applicability of assisted evolution via selective breeding |
10.1029/2019jd030480 | 17,571,393 | Abstract Sudden stratospheric warmings (SSWs) have been linked with anomalously cold temperatures at the surface in the middle to high latitudes of the Northern Hemisphere as climatological westerly winds in the stratosphere tend to weaken and turn easterly. However, previous studies have largely relied on reanalyses a... | 10.1038/s43247-020-00060-z | Disruptions of the polar vortex have an effect not just on the mean climate over Europe but also on surface extremes |
10.1038/s41612-018-0054-4 | 101,295,330 | Abstract The stratospheric polar vortex can influence the tropospheric circulation and thereby winter weather in the mid-latitudes. Weak vortex states, often associated with sudden stratospheric warmings (SSW), have been shown to increase the risk of cold-spells especially over Eurasia, but its role for North American ... | 10.1038/s43247-020-00060-z | Different structures of the stratospheric polar vortex can have unique impacts on surface extremes over Eurasia and North America. |
10.1029/2019jd032362 | 100,323,978 | Abstract The quasi‐biennial oscillation (QBO) of the zonal mean zonal wind is the primary mode of variability in the tropical lower stratosphere. The QBO is characterized by alternating easterly westerly shear layers that descend down from ∼10 to 100 hPa. The QBO is also seen in lower stratospheric tropical temperature... | 10.1038/s43247-020-00060-z | More coupled atmosphere-ocean climate models are able to internally generate the Quasi-biennial Oscillation, but biases in the vertical extent and amplitude persist. |
10.1175/jcli-d-16-0620.1 | 20,666,175 | Abstract Interannual variation of seasonal-mean tropical convection over the Indo-Pacific region is primarily controlled by El Niño–Southern Oscillation (ENSO). For example, during El Niño winters, seasonal-mean convection around the Maritime Continent becomes weaker than normal, while that over the central to eastern ... | 10.1038/s43247-020-00060-z | Tropical convection associated with the Madden-Julian Oscillation is stronger and more organized when the tropical stratospheric winds are easterly. |
10.1029/2019jd030923 | 81,514,620 | Abstract The stratosphere can have a significant impact on winter surface weather on subseasonal to seasonal (S2S) timescales. This study evaluates the ability of current operational S2S prediction systems to capture two important links between the stratosphere and troposphere: (1) changes in probabilistic prediction s... | 10.1038/s43247-020-00060-z | Variability in the stratosphere impacts surface predictive skill on sub-seasonal timescales |
10.1002/qj.3158 | 39,798,880 | Wind power is playing an increasingly important role in Europe's electricity generation. Accurate forecasts of wind‐power output on various spatial and temporal scales are therefore of high interest for the energy industry. However, predictability of near‐surface wind on subseasonal time‐scales has received relatively ... | 10.1038/s43247-020-00060-z | Winds in the lower stratosphere can be used for skillful forecasts of European wind electricity generation up to one month ahead of time. |
10.1038/s41467-017-00322-z | 122,974,736 | Abstract Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis in this disease. Here, w... | 10.1038/s43587-022-00336-3 | This paper reports the expansion of nucleoli and increased protein synthesis in patients with Hutchinson–Gilford progeria syndrome, as well as during aging in healthy humans. |
10.1038/ncomms16083 | 83,184,817 | Abstract Animal lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors, but whether these pathways affect common downstream mechanisms remains largely elusive. Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the major C. ele... | 10.1038/s43587-022-00336-3 | This paper reports that nucleolar size is a cellular hallmark that is highly predictive of longevity in the nematode C. elegans. |
10.1063/1.4986627 | 91,840,335 | X-ray absorption spectroscopy at the L-edge of 3d transition metals provides unique information on the local metal charge and spin states by directly probing 3d-derived molecular orbitals through 2p-3d transitions. However, this soft x-ray technique has been rarely used at synchrotron facilities for mechanistic studies... | 10.1038/s42254-021-00289-3 | This Mn L-edge soft X-ray spectroscopic study of PS II at physiological (in operando) conditions based on measurements at the LCLS XFEL establishes protocols for probe-before-destroy spectroscopy of dilute high-valent metal complexes and proteins at XFELs |
10.1073/pnas.2000529117 | 41,385,793 | In oxygenic photosynthesis, light-driven oxidation of water to molecular oxygen is carried out by the oxygen-evolving complex (OEC) in photosystem II (PS II). Recently, we reported the room-temperature structures of PS II in the four (semi)stable S-states, S 1 , S 2 , S 3 , and S 0 , showing that a water molecule is in... | 10.1038/s42254-021-00289-3 | The application of combined X-ray crystallography and XES at an XFEL to understand the sequence of events during the water oxidation reaction in PS II |
10.1038/s41467-019-11499-w | 41,543,481 | Abstract Disentangling the strong interplay between electronic and nuclear degrees of freedom is essential to achieve a full understanding of excited state processes during ultrafast nonadiabatic chemical reactions. However, the complexity of multi-dimensional potential energy surfaces means that this remains challengi... | 10.1038/s42254-021-00289-3 | This study on the femtosecond excited-state dynamics of a Cu complex in solution based on time-resolved Cu K-edge hard XAS at the SACLA XFEL reports the observation of hitherto unreported nuclear wavepacket dynamics and a new mechanism for the ultrafast relaxation in the photochemical reaction of this complex |
10.3390/diagnostics9040207 | 102,438,934 | The aim of this study was to systematically review the performance of deep learning technology in detecting and classifying pulmonary nodules on computed tomography (CT) scans that were not from the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) database. Furthermore, we explored the ... | 10.1038/s43856-022-00199-0 | The studies reviewed reached a classification accuracy between 68-99.6% and a detection accuracy between 80.6-94% |
10.1073/pnas.1707849114 | 103,246,973 | Foundry-based routes to transient silicon electronic devices have the potential to serve as the manufacturing basis for “green” electronic devices, biodegradable implants, hardware secure data storage systems, and unrecoverable remote devices. This article introduces materials and processing approaches that enable stat... | 10.1038/s41928-022-00796-w | This paper describes release schemes and transfer printing methods for foundry-compatible transient electronics. |
10.1002/adfm.201910718 | 20,584,592 | Abstract Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes ... | 10.1038/s41928-022-00796-w | This paper reports a natural wax mixture that can function as a bioresorbable encapsulating material. |
10.1146/annurev-physiol-021119-034338 | 104,417,834 | Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health. End-organ effects are diverse, resulting in b... | 10.1038/s43587-022-00355-0 | This review outlines recent advances in our understanding of the biology and determinants of cerebral small vessel disease. |
10.1038/s41467-020-14330-z | 122,537,670 | Abstract Active nerve cells release vasodilators that increase their energy supply by dilating local blood vessels, a mechanism termed neurovascular coupling and the basis of BOLD functional neuroimaging signals. Here, we reveal a mechanism for cerebral blood flow control, a precapillary sphincter at the transition bet... | 10.1038/s43587-022-00355-0 | This paper reports that precapillary sphincters are a new important regulator of capillary blood flow. |
10.1063/1.126902 | 39,339,138 | Thin oxide films with perovskite or related structures and with transition metal doping show a reproducible switching in the leakage current with a memory effect. Positive or negative voltage pulses can switch the resistance of the oxide films between a low- and a high-impedance state in times shorter than 100 ns. The ... | 10.1038/s41928-018-0092-2 | This is the first work demonstrating reproducible resistance switching in an oxide layer, thus paving the way for memory applications |
10.1002/adfm.201202383 | 104,076,229 | Abstract Historically, the application of phase‐change materials and devices has been limited to the provision of non‐volatile memories. Recently, however, the potential has been demonstrated for using phase‐change devices as the basis for new forms of brain‐like computing, by exploiting their multilevel resistance cap... | 10.1038/s41928-018-0092-2 | This is the first work proposing the use of cumulative crystallization in PCM as a means for analogue computation and neuron-like integration |
10.1126/science.aaf4767 | 20,829,322 | Small and salty CO 2 reduction scheme Most artificial photosynthesis approaches focus on making hydrogen. Modifying CO 2 , as plants and microbes do, is more chemically complex. Asadi et al. report that fashioning WSe 2 and related electrochemical catalysts into nanometer-scale flakes greatly improves their activity fo... | 10.1038/s41929-018-0181-7 | Elucidates exfoliation of layered transition metal dichalcogenides to nanosheets which exhibit enhanced CO 2 reduction efficiency compared to their bulk counterparts due to the generation of a higher number of edges |
10.1002/anie.201309171 | 102,879,885 | Abstract The oxygen reduction reaction (ORR) is of high industrial importance. There is a large body of literature showing that metal‐based catalytic nanoparticles (e.g. Co, Mn, Fe or hybrid Mn/Co‐based nanoparticles) supported on graphene act as efficient catalysts for the ORR. A significant research effort is also di... | 10.1038/s41929-018-0181-7 | Demonstrates that traces of metal impurities are sufficient to influence the performance of graphene as an oxygen reduction reaction catalyst |
10.1002/adfm.201604943 | 123,064,289 | Molybdenum disulfide (MoS 2 ) has been considered as a promising alternative to platinum (Pt)‐based catalyst for hydrogen evolution reaction (HER) due to its low cost and high catalytic activity. However, stable 2H phase of MoS 2 (2H‐MoS 2 ) exhibits low catalytic activity in HER due to the inert basal plane and S‐edge... | 10.1038/s41929-018-0181-7 | Depicts that functionalization of the inert basal planes and S-edges of MoS 2 by doping resulted in enhanced catalyst behaviour for hydrogen evolution reaction |
10.1002/adma.201701546 | 103,695,648 | An earth‐abundant and highly efficient electrocatalyst is essential for oxygen evolution reaction (OER) due to its poor kinetics. Layered double hydroxide (LDH)‐based nanomaterials are considered as promising electrocatalysts for OER. However, the stacking structure of LDHs limits the exposure of the active sites. Ther... | 10.1038/s41929-018-0181-7 | Elucidates water–plasma-enabled exfoliation of layered CoFe double hydroxide nanosheets that generates multiple Co, Fe and O vacancies, which lower the adsorption energy of water, in turn leading to an enhanced catalytic oxygen evolution reaction |
10.1002/adma.201905440 | 103,555,217 | Abstract Due to the ubiquitous presence of lithium‐ion batteries in portable applications, and their implementation in the transportation and large‐scale energy sectors, the future cost and availability of lithium is currently under debate. Lithium demand is expected to grow in the near future, up to 900 ktons per year... | 10.1038/s43017-022-00387-5 | Critical review about electrochemical ion pumping technologies, with suggestions about which experimental parameters need to be assessed. Not all electrochemical technologies are reviewed. |
10.1098/rsos.201130 | 38,877,287 | Urban transportation networks, from pavements and bicycle paths to streets and railways, provide the backbone for movement and socioeconomic life in cities. To make urban transport sustainable, cities are increasingly investing to develop their bicycle networks. However, it is yet unclear how to extend them comprehensi... | 10.1038/s43588-022-00324-y | This paper reports a percolation approach to connect the fragmented bike path network of a city. |
10.1038/ncomms10441 | 107,353,101 | Abstract A number of important transport networks, such as the airline and trade networks of the world, exhibit a characteristic core–periphery structure, wherein a few nodes are highly interconnected and the rest of the network frays into a tree. Mechanisms underlying the emergence of core–peripheries, however, remain... | 10.1038/s43588-022-00324-y | This paper employs inverse percolation to model the core–periphery structure of airline networks. |
10.1177/23998083221135611 | 141,035,947 | Developing safe infrastructure for micromobility like bicycles or e-scooters is an efficient pathway towards climate-friendly, sustainable, and livable cities. However, urban micromobility infrastructure is typically planned ad-hoc and at best informed by survey data. Here, we study how data of micromobility trips and ... | 10.1038/s43588-022-00324-y | This preprint article reports a network planning approach including empirical accident risk. |
10.1002/anie.201814457 | 62,589,317 | Abstract This Review summarizes advances in fluorination by C(sp 2 )−H and C(sp 3 )−H activation. Transition‐metal‐catalyzed approaches championed by palladium have allowed the installation of a fluorine substituent at C(sp 2 ) and C(sp 3 ) sites, exploiting the reactivity of high‐oxidation‐state transition‐metal fluor... | 10.1038/s43586-021-00042-1 | This article is a concise review on fluorination of C−H bonds |
10.1126/science.aar7941 | 38,397,335 | H-bond to deliver fluoride Simple fluoride salts are theoretically convenient reagents for carbon-fluorine bond formation. In practice, they are often insoluble in the solvents that dissolve their reaction partners. Pupo et al. developed urea-based catalysts that make fluoride soluble through hydrogen bonding. Moreover... | 10.1038/s43586-021-00042-1 | This article provides a conceptually novel method for asymmetric nucleophilic fluorination |
10.1126/science.1190524 | 107,185,271 | Three Fluorines at Once The trifluoromethyl (CF 3 ) group is playing an increasingly important role in the design of pharmaceutical and agrochemical compounds. CF 3 is a powerful attractor of electron density within a given molecular framework, and recently fluorine-hydrocarbon interactions have emerged as a distinct c... | 10.1038/s43586-021-00042-1 | This article describes the trifluoromethylation of aryl chlorides via a Pd 0 /Pd II catalytic cycle |
10.1073/pnas.0608262103 | 109,089,955 | Two-photon excitation is gaining rapidly in interest and significance in spectroscopy and microscopy. Here we introduce a new approach that suggests versatile optical labels suitable for both one- and two-photon excitation and also two-photon-excited ultrasensitive, nondestructive chemical probing. The underlying spect... | 10.1038/s43586-021-00075-6 | Application of HRS for the detection of complementary peaks of biomolecules and cells |
10.1073/pnas.1902322116 | 83,019,122 | Combining the strength of flow cytometry with fluorescence imaging and digital image analysis, imaging flow cytometry is a powerful tool in diverse fields including cancer biology, immunology, drug discovery, microbiology, and metabolic engineering. It enables measurements and statistical analyses of chemical, structur... | 10.1038/s43586-021-00075-6 | Development of a high-throughput Raman-based flow cell counter for microalgae based on multicolour-SRS microscopy and deep learning |
10.1111/j.1462-2920.2007.01352.x | 82,374,746 | Summary We have coupled fluorescence in situ hybridization (FISH) with Raman microscopy for simultaneous cultivation‐independent identification and determination of 13 C incorporation into microbial cells. Highly resolved Raman confocal spectra were generated for individual cells which were grown in minimal medium wher... | 10.1038/s43586-021-00075-6 | First demonstration of the combination of FISH, SIP and Raman microspectroscopy |
10.1038/s41467-020-18928-1 | 20,639,672 | Abstract Many intestinal pathogens, including Clostridioides difficile , use mucus-derived sugars as crucial nutrients in the gut. Commensals that compete with pathogens for such nutrients are therefore ecological gatekeepers in healthy guts, and are attractive candidates for therapeutic interventions. Nevertheless, th... | 10.1038/s43586-021-00075-6 | Application of a high-throughput optofluidic RACS platform and mini-metagenomics to identify mucosal sugar degraders within gut microbiota and use of this information to rationally design a probiotic mixture of microorganisms that could reduce pathogen colonization |
10.1073/pnas.1420406112 | 125,210,609 | Microbial communities are essential to the function of virtually all ecosystems and eukaryotes, including humans. However, it is still a major challenge to identify microbial cells active under natural conditions in complex systems. In this study, we developed a new method to identify and sort active microbes on the si... | 10.1038/s43586-021-00075-6 | First study combining deuterium labelling, RACS and 16S ribosomal RNA gene sequencing, which together led to the identification of novel glucosamine- and mucin-utilizing bacteria from mouse gut microbiota |
10.1038/s41396-019-0399-7 | 125,250,736 | Abstract Enhanced biological phosphorus removal (EBPR) is a globally important biotechnological process and relies on the massive accumulation of phosphate within special microorganisms. Candidatus Accumulibacter conform to the classical physiology model for polyphosphate accumulating organisms and are widely believed ... | 10.1038/s43586-021-00075-6 | Application of FISH–Raman to quantify the amount of polyphosphate in various microbial taxa in wastewater treatment plants, showing that Tetrasphaera have a more important role in enhanced biological phosphorus removal than previously thought |
10.1038/s41467-019-12898-9 | 20,628,592 | Abstract Raman optical spectroscopy promises label-free bacterial detection, identification, and antibiotic susceptibility testing in a single step. However, achieving clinically relevant speeds and accuracies remains challenging due to weak Raman signal from bacterial cells and numerous bacterial species and phenotype... | 10.1038/s43586-021-00075-6 | Application of Raman spectroscopy and deep learning to identify 30 common bacterial pathogens with high accuracy (up to 97%) |
10.1002/advs.202001452 | 40,286,691 | Abstract Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic‐resistant bacteria. Here, a phenotypic platform that rapidly produces AST results by femtosecond stimulated Raman scattering imaging of deuterium... | 10.1038/s43586-021-00075-6 | Rapid antimicrobial susceptibility testing based on femtosecond SRS imaging of deuterium incorporation into cells of interest |
10.1073/pnas.1800367115 | 82,785,549 | Electron transport within living cells is essential for energy conservation in all respiring and photosynthetic organisms. While a few bacteria transport electrons over micrometer distances to their surroundings, filaments of cable bacteria are hypothesized to conduct electric currents over centimeter distances. We use... | 10.1038/s43586-021-00075-6 | Resonance Raman measurements of cytochrome demonstrates long-distance electron transport over micrometres in cable bacteria |
10.1111/j.1365-2958.2010.07241.x | 82,587,745 | Summary The phylum Chlamydiae consists exclusively of obligate intracellular bacteria. Some of them are formidable pathogens of humans, while others occur as symbionts of amoebae. These genetically intractable bacteria possess a developmental cycle consisting of replicative reticulate bodies and infectious elementary b... | 10.1038/s43586-021-00075-6 | By using Raman microspectroscopy to differentiate developmental stages of chlamydiae and to investigate the physiological activity of these stages by single-cell SIP it could be demonstrated that in contrast to textbook knowledge elementary bodies of Chlamydia are physiologically active outside of their host cells — a ... |
10.1038/ncomms10095 | 103,792,554 | Abstract In the last couple of decades, the spatial resolution in optical microscopy has increased to unprecedented levels by exploiting the fluorescence properties of the probe. At about the same time, Raman imaging techniques have emerged as a way to image inherent chemical information in a sample without using fluor... | 10.1038/s43586-021-00075-6 | Super-resolution Raman microscopy structured line illumination to increase the spatial resolution below the Rayleigh limit |
10.1002/anie.201503595 | 62,076,442 | Abstract Much research has been carried out in the last decade to convert bio‐based feedstock into fuels and chemicals. Most of the research focuses on developing active and selective catalysts, with much less attention devoted to their long‐term stability. This Review considers the main challenges in long‐term catalys... | 10.1038/s41929-022-00842-y | Highlights the main challenges concerning the long-term stability of catalysts for the conversion of bio-based feedstock into fuels and chemicals |
10.1126/science.1213194 | 123,026,946 | Tracking Reaction Surfaces Gold becomes a remarkably active catalyst for CO oxidation when it is dispersed as nanoparticles on the surface of reducible metal oxides such as ceria, so much so that the reaction proceeds at room temperature. Yoshida et al. (p. 317 ) used an aberration-corrected, environmental transmission... | 10.1038/s41929-022-00842-y | Uses aberration-corrected transmission electron microscopy to visualize changes in both ceria-supported gold nanoparticles and the adsorbed species during CO oxidation |
10.1126/science.aau4821 | 96,329,855 | Exploration of intermediates that enable chemoselective cycloaddition reactions and expeditious construction of fused- or bridged-ring systems is a continuous challenge for organic synthesis. As an intermediate of interest, the oxyallyl cation has been harnessed to synthesize architectures containing seven-membered rin... | 10.1038/s44160-022-00151-z | This paper reports the first catalytic (3 + 2) cycloaddition of palladium–oxyallyl with conjugated dienes. |
10.1126/science.aao5894 | 41,334,801 | Small-molecule dual hydrogen-bond (H-bond) donors such as ureas, thioureas, squaramides, and guanidinium ions enjoy widespread use as effective catalysts for promoting a variety of enantioselective reactions. However, these catalysts are only weakly acidic and therefore require highly reactive electrophilic substrates ... | 10.1038/s44160-022-00151-z | This paper reports the asymmetric (3 + 2) cycloaddition of oxyallyl cations with furans. |
10.1126/science.1259855 | 125,335,278 | Crossing the boundaries in global sustainability The planetary boundary (PB) concept, introduced in 2009, aimed to define the environmental limits within which humanity can safely operate. This approach has proved influential in global sustainability policy development. Steffen et al. provide an updated and extended an... | 10.1038/s43017-022-00287-8 | Revises and updates the planetary boundaries framework, including a regional-scale planetary boundary for freshwater use based on environmental flow requirements |
10.1038/srep20018 | 81,688,665 | Abstract Ecosystems may exhibit alternative stable states (ASS) in response to environmental change. Modelling and observational data broadly support the theory of ASS, however evidence from manipulation experiments supporting this theory is limited. Here, we provide long-term manipulation and observation data supporti... | 10.1038/s43017-022-00287-8 | Manipulation experiments demonstrate the presence of drought-driven irreversible tipping points of soil moisture states, in support of previous modelling and observation-based studies |
10.1126/science.abb3368 | 61,669,811 | Unprecedented heatwave-drought concurrences in the past two decades have been reported over inner East Asia. Tree-ring–based reconstructions of heatwaves and soil moisture for the past 260 years reveal an abrupt shift to hotter and drier climate over this region. Enhanced land-atmosphere coupling, associated with persi... | 10.1038/s43017-022-00287-8 | Analyses based on tree-ring data over the past 260 years show an abrupt shift that could potentially be explained by self-amplifying feedbacks of soil moisture deficit and surface warming, which points towards risk for an irreversible tipping point in the East Asian climate system under climate change |
10.1002/wat2.1406 | 4,706,191 | Abstract A review of the literature on water governance reveals that most studies focus on blue water governance; while there is some literature on green and atmospheric water, explicit literature on how to govern green and atmospheric water is lacking. Hence, this paper addresses the question: What are the arguments f... | 10.1038/s43017-022-00287-8 | Provides rationales for the need for regulating and governing human interference with green water and atmospheric water |
10.1073/pnas.1712381114 | 41,711,161 | Plant rooting depth affects ecosystem resilience to environmental stress such as drought. Deep roots connect deep soil/groundwater to the atmosphere, thus influencing the hydrologic cycle and climate. Deep roots enhance bedrock weathering, thus regulating the long-term carbon cycle. However, we know little about how de... | 10.1038/s43017-022-00287-8 | Shows that rooting depths globally are highly adaptive to hydroclimate, topography and soil hydrology, with implications for improving the representation of plant–water interactions in Earth system models |
10.1073/pnas.1934654100 | 41,532,464 | An unresolved question in cardiac biology is whether distinct signaling pathways are responsible for the development of pathological and physiological cardiac hypertrophy in the adult. Physiological hypertrophy is characterized by a normal organization of cardiac structure and normal or enhanced cardiac function, where... | 10.1038/s42255-020-0262-1 | This article shows that PI3K is required for the induction of physiological cardiac growth and is essential for maintaining contractile function in response to pathological stimuli |
10.1098/rsta.2018.0009 | 102,564,990 | The thermal and therefore physical state of magma bodies within the crust controls the processes and time scales required to mobilize magmas before eruptions, which in turn are critical to hazard assessment. Crystal records can be used to reconstruct magma reservoir histories, and the resulting time and length scales a... | 10.1038/s43017-020-0038-x | Contains a very detailed compilation of timescales obtained from diffusion chronometry and U-Th dating, and a discussion of the hot and cold magma-storage hypothesis |
10.1126/science.aam8720 | 80,454,198 | Taupo Volcanic Zone magma spent more than 90% of its life deep and crystalline before rapid shallow accumulation and eruption. | 10.1038/s43017-020-0038-x | Reports timescales from diffusion chronometry and dating of zircon from the same crystal zones. The results of long storage at low temperature generated significant discussion, especially for the application of Li diffusion in zircon |
10.1126/science.1100035 | 20,674,845 | Large, living biological specimens present challenges to existing optical imaging techniques because of their absorptive and scattering properties. We developed selective plane illumination microscopy (SPIM) to generate multidimensional images of samples up to a few millimeters in size. The system combines two-dimensio... | 10.1038/s43586-021-00069-4 | This work describes the first diffraction-limited LSM in the form of the selective/single plane illumination implementation (SPIM), which uses a cylindrical lens to generate a static light sheet |
10.1126/science.1162493 | 62,323,518 | A long-standing goal of biology is to map the behavior of all cells during vertebrate embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy and recorded nuclei localization and movement in entire wild-type and mutant zebrafish embryos over the first 24 hours of development. Multiview in ... | 10.1038/s43586-021-00069-4 | This work presents the first digital scanned laser light sheet-based fluorescence implementation (DSLM), which used beam scanning to generate a dynamic light sheet |
10.1242/dev.082586 | 80,680,801 | Light sheet microscopy techniques, such as selective plane illumination microscopy (SPIM), are ideally suited for time-lapse imaging of developmental processes lasting several hours to a few days. The success of this promising technology has mainly been limited by the lack of suitable techniques for mounting fragile sa... | 10.1038/s43586-021-00069-4 | This work describes a method that allows for stacking multiple zebrafish embryos into one sample holder for multi-embryo imaging within a single experiment |
10.1046/j.1365-2818.2000.00710.x | 83,318,735 | Lateral resolution that exceeds the classical diffraction limit by a factor of two is achieved by using spatially structured illumination in a wide‐field fluorescence microscope. The sample is illuminated with a series of excitation light patterns, which cause normally inaccessible high‐resolution information to be enc... | 10.1038/s43586-021-00069-4 | This work introduces SIM, a method that can double the resolving power of a microscope |
10.1126/science.1260088 | 20,691,552 | Overcoming the limits of the microscope The resolution of a light microscope is limited. Physicists have long since worked out what these limits are and which parameters determine the spatial resolution. Many groups have nevertheless made numerous attempts to overcome these resolution limits. Rather than improving the ... | 10.1038/s43586-021-00069-4 | This work introduces expansion microscopy, a super-resolution technique that is based on physically expanding the sample |
10.1002/anie.202007040 | 82,818,000 | Abstract The development of fluorophores for the second near‐infrared window (NIR‐II, 1000–1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, and biomedical engineering. The wavelength, brightness, and stability are three crucial factors that determine the performan... | 10.1038/s44222-022-00002-8 | This review summarizes strategies to develop molecular fluorophores with high brightness and long wavelengths |
10.1186/s12872-021-02137-9 | 135,384,198 | Abstract Background The relative association between cardiovascular (CV) risk factors, such as diabetes and hypertension, established CV disease (CVD), and susceptibility to CV complications or mortality in COVID-19 remains unclear. Methods We conducted a cohort study of consecutive adults hospitalised for severe COVID... | 10.1038/s44161-022-00029-5 | Results from a cohort study of more than 1,700 consecutive adults hospitalized for severe COVID-19 in the United Kingdom showing that preexisting established cardiovascular disease is a more important contributor to mortality than cardiovascular risk factors in the absence of cardiovascular disease |
10.1126/sciadv.aat8131 | 102,631,227 | Intracellular delivery of mRNA, DNA, and other large macromolecules into cells plays an essential role in an array of biological research and clinical therapies. However, current methods yield a wide variation in the amount of material delivered, as well as limitations on the cell types and cargoes possible. Here, we d... | 10.1038/s44222-022-00010-8 | This article reports a nanostraw array that, combined with low-voltage electroporation, enables controlled cytosolic delivery of gene editing cargos such as siRNA and Cas9 ribonucleoproteins. |
10.1017/cbo9780511489662 | 81,688,209 | In this ground-breaking work, Norman Yoffee shatters the prevailing myths underpinning our understanding of the evolution of early civilisations. He counters the emphasis in traditional scholarship on the rule of 'godly' and despotic male leaders and challenges the conventional view that early states were uniformly con... | 10.1038/s41893-022-00907-7 | This book depicts the evolutionary processes of complex societies across the world based on archaeological evidence |
10.1017/cbo9781139022682 | 104,042,537 | This volume aims to satisfy a pressing need for an updated account of Chinese archaeology. It covers an extended time period from the earliest peopling of China to the unification of the Chinese Empire some two thousand years ago. The geographical coverage includes the traditional focus on the Yellow River basin but al... | 10.1038/s41893-022-00907-7 | This book introduces the social development trajectory of early China, especially the development of socio-political complexity based on updated archaeological studies |
10.1126/sciadv.aax6225 | 38,309,394 | Although broomcorn and foxtail millet are among the earliest staple crop domesticates, their spread and impacts on demography remain controversial, mainly because of the use of indirect evidence. Bayesian modeling applied to a dataset of new and published radiocarbon dates derived from domesticated millet grains sugges... | 10.1038/s41893-022-00907-7 | A review article that presents the origin and spread of millet-based agriculture across eastern Asia and reveals the importance of millet farming in underpinning the population growth in North China |
10.1073/pnas.0809960106 | 62,465,162 | Stable isotope biochemistry (δ 13 C and δ 15 N) and radiocarbon dating of ancient human and animal bone document 2 distinct phases of plant and animal domestication at the Dadiwan site in northwest China. The first was brief and nonintensive: at various times between 7900 and 7200 calendar years before present (calBP) ... | 10.1038/s41893-022-00907-7 | This paper reports isotopic evidence for the early domestication of millets (7,800–7,200 cal yr bp) and the use of intensive millet agriculture by 5,900 cal yr bp at Dadiwan |
10.1038/s41598-018-23315-4 | 81,543,098 | Abstract Research in to the nature of Neolithic agriculture in China is often focused on topics such as the domestication and spread of cereal crops and the reconstruction of human and animal diets in the past. Field management practices, such as organic manuring, have not been systematically investigated in Chinese ar... | 10.1038/s41893-022-00907-7 | This article provides the first evidence for millet manuring practices during the Late Neolithic period in North China |
10.1038/s41586-019-1913-9 | 125,292,520 | Abstract A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes 1–7 . Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analys... | 10.1038/s42003-021-02020-5 | In this paper, Li et al. provided the largest and most detailed description of the landscape of structural variation (SV) in the cancer genome to date, demonstrating that specific SV signatures were enriched in certain tumour types |
10.1101/gr.177121.114 | 83,538,863 | Copy number variants (CNVs) resulting from genomic deletions and duplications and common fragile sites (CFSs) seen as breaks on metaphase chromosomes are distinct forms of structural chromosome instability precipitated by replication inhibition. Although they share a common induction mechanism, it is not known how CNVs... | 10.1038/s42003-021-02020-5 | In this study, Wilson et al. induced CNV hotpots using aphidicolin (APH), hydroxyurea (HU), or ionizing radiation (IR) and demonstrated these CNVs occurred in the same location as common fragile sites and corresponded to the largest active transcription units in both human and mouse cells |
10.1073/pnas.79.8.2554 | 62,587,501 | Computational properties of use of biological organisms or to the construction of computers can emerge as collective properties of systems having a large number of simple equivalent components (or neurons). The physical meaning of content-addressable memory is described by an appropriate phase space flow of the state o... | 10.1038/s43588-023-00411-8 | A seminal work on the application of spin models to the study of neural networks. |
10.1002/rog.20023 | 123,902,341 | Abstract The stable oxygen isotope ratio (δ 18 O) in precipitation is an integrated tracer of atmospheric processes worldwide. Since the 1990s, an intensive effort has been dedicated to studying precipitation isotopic composition at more than 20 stations in the Tibetan Plateau (TP) located at the convergence of air mas... | 10.1038/s43017-022-00299-4 | This work proposes a conceptual framework of three distinct modes that control moisture transport over the Tibetan Plateau |
10.1126/science.1225829 | 20,844,166 | Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated adaptive immune system called CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated (Cas). Jinek et al. (p. 816 , published online 28 June; see the Perspective by Brou... | 10.1038/s44222-022-00013-5 | This article contains the first description of the CRISPR–Cas9 system as a potential tool for RNA-programmable genome engineering |
10.1002/anie.201801592 | 101,824,569 | Abstract We report a unique strategy for the development of a H 2 O 2 ‐dependent cytochrome P450BM3 system, which catalyzes the monooxygenation of non‐native substrates with the assistance of dual‐functional small molecules (DFSMs), such as N ‐(ω‐imidazolyl fatty acyl)‐ l ‐amino acids. The acyl amino acid group of DFSM... | 10.1038/s41929-020-00507-8 | In this study, the P450 monooxygenase BM-3 was converted into a peroxygenase by the exogenous addition of a small molecule comprising a substrate mimicking part to activate the enzyme towards low-molecular-weight substrates and to anchor the molecule to the active site and an acid–base catalyst to enable H 2 O 2 -usage |
10.1038/s41467-020-15170-7 | 38,784,920 | Abstract Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic me... | 10.1038/s42003-020-01539-3 | This study has discussed the existence of a second DPC protease in humans. |
10.1038/s41467-019-11095-y | 101,639,453 | Abstract The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidence suggestin... | 10.1038/s42003-020-01539-3 | This study has discovered one of the non-DPC-related functions of proteases |
10.1038/s41467-020-15000-w | 83,454,176 | Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate—a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)—is stabilised. TOP1ccs ... | 10.1038/s42003-020-01539-3 | This article has identified the first DPC-specific cofactor for the ATPase p97 |
10.1038/ncomms6427 | 82,904,479 | Abstract Blood stream infection or sepsis is a major health problem worldwide, with extremely high mortality, which is partly due to the inability to rapidly detect and identify bacteria in the early stages of infection. Here we present a new technology termed ‘Integrated Comprehensive Droplet Digital Detection’ (IC 3D... | 10.1038/s43586-022-00190-y | This study presents an integrated comprehensive droplet digital detection system that can detect bacteria in diluted blood at the single-cell resolution |
10.1073/pnas.1819569116 | 124,477,122 | Infectious diseases caused by bacterial pathogens remain one of the most common causes of morbidity and mortality worldwide. Rapid microbiological analysis is required for prompt treatment of bacterial infections and to facilitate antibiotic stewardship. This study reports an adaptable microfluidic system for rapid pat... | 10.1038/s43586-022-00190-y | This study presents an adaptable microfluidic device that isolates individual bacterial cells in channels, performs pathogen classification based on bacterial shape and size, and conducts phenotypic AST at the single-cell level |
10.1073/pnas.1922172117 | 60,857,279 | The lack of rapid antibiotic susceptibility tests adversely affects the treatment of bacterial infections and contributes to increased prevalence of multidrug-resistant bacteria. Here, we describe an all-electrical approach that allows for ultrasensitive measurement of growth signals from only tens of bacteria in a mic... | 10.1038/s43586-022-00190-y | This study demonstrates a microfluidic device that allows for sensitive detection of single bacterial cell growth via all-electrical means |
10.1126/science.288.5463.113 | 20,644,081 | Soft lithography is an alternative to silicon-based micromachining that uses replica molding of nontraditional elastomeric materials to fabricate stamps and microfluidic channels. We describe here an extension to the soft lithography paradigm, multilayer soft lithography, with which devices consisting of multiple layer... | 10.1038/s43586-022-00190-y | This study demonstrates the active microfluidic on–off valves via soft lithography |
10.1002/advs.202003419 | 62,286,941 | Abstract Empiric broad‐spectrum antimicrobial treatments of urinary tract infections (UTIs) have contributed to widespread antimicrobial resistance. Clinical adoption of evidence‐based treatments necessitates rapid diagnostic methods for pathogen identification (ID) and antimicrobial susceptibility testing (AST) with m... | 10.1038/s43586-022-00190-y | This study demonstrates a droplet-based system that can isolate a single bacterium in droplets, probe 16S rRNA for pathogen identification and quantify the concentration of the 16S rRNA in response to antibiotics to determine AST results |
10.1073/pnas.1703736114 | 80,987,814 | Antibiotic resistance is a major global health concern that requires action across all sectors of society. In particular, to allow conservative and effective use of antibiotics clinical settings require better diagnostic tools that provide rapid determination of antimicrobial susceptibility. We present a method for rap... | 10.1038/s43586-022-00190-y | This study presents a simple yet efficient device for rapid AST by testing bacterial metabolism products in an array of nanolitre wells |
10.1126/scitranslmed.3009650 | 103,998,174 | An antimicrobial susceptibility test rapidly identifies bacterial response to drugs based on imaged morphology of single cells. | 10.1038/s43586-022-00190-y | This study demonstrates rapid AST by capturing bacteria in agarose and, subsequently, monitoring individual bacterial growth in the presence of antibiotics |
10.1038/s41467-020-18902-x | 45,465,181 | Abstract There is an urgent need to develop simple and fast antimicrobial susceptibility tests (ASTs) that allow informed prescribing of antibiotics. Here, we describe a label-free AST that can deliver results within an hour, using an actively dividing culture as starting material. The bacteria are incubated in the pre... | 10.1038/s43586-022-00190-y | This study demonstrates a microfluidic channel device that performs rapid AST by examining the impedance signal of the channel caused by individual bacteria passing through the channel |
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