Datasets:
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GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0002287
2,287
alpha-beta T cell activation involved in immune response
biological_process
The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "alpha-beta T cell activation during immune response", "alpha-beta T lymphocyte activation during immune response", "alpha-beta T-cell activation during immune response", "alpha-beta T-lymphocyte activation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002286", "GO:0046631" ]
[]
[]
[]
[ "GO:0002286", "GO:0046631" ]
[ "GO:0046631", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002288
2,288
obsolete NK T cell activation involved in immune response
biological_process
OBSOLETE. The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
[ "GOC:add", "PMID:15771592" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "natural killer T lymphocyte activation during immune response", "natural killer T-cell activation during immune response", "natural killer T-lymphocyte activation during immune response", "NK T cell activation during immune response", "NK T lymphocyte activation during immune response", "NK T-cell activa...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
4
GO:0002289
2,289
obsolete NK T cell proliferation involved in immune response
biological_process
OBSOLETE. The expansion of a NK T cell population by cell division as part of an immune response.
[ "GOC:add", "PMID:15771592" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "natural killer T lymphocyte proliferation during immune response", "natural killer T-cell proliferation during immune response", "natural killer T-lymphocyte proliferation during immune response", "NK T cell proliferation during immune response", "NK T lymphocyte proliferation during immune response", "N...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31306\" xsd:anyURI" ]
null
null
true
true
4
GO:0002290
2,290
obsolete gamma-delta T cell activation involved in immune response
biological_process
OBSOLETE. The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
[ "GOC:add", "PMID:8717523" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "gamma-delta T cell activation during immune response", "gamma-delta T lymphocyte activation during immune response", "gamma-delta T-cell activation during immune response", "gamma-delta T-lymphocyte activation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006955" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
7
GO:0002291
2,291
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
biological_process
The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell", "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molec...
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002286" ]
[]
[]
[]
[ "GO:0002286" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002292
2,292
T cell differentiation involved in immune response
biological_process
The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "T cell development involved in immune response", "T cell differentiation during immune response", "T lymphocyte differentiation during immune response", "T-cell differentiation during immune response", "T-lymphocyte differentiation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002286", "GO:0030217" ]
[]
[]
[]
[ "GO:0002286", "GO:0030217" ]
[ "GO:0030217", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002293
2,293
obsolete alpha-beta T cell differentiation involved in immune response
biological_process
OBSOLETE. The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
[ "GOC:add", "ISBN:0781735149" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "alpha-beta T cell development involved in immune response", "alpha-beta T cell differentiation during immune response", "alpha-beta T lymphocyte differentiation during immune response", "alpha-beta T-cell differentiation during immune response", "alpha-beta T-lymphocyte differentiation during immune respon...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
5
GO:0002294
2,294
obsolete CD4-positive, alpha-beta T cell differentiation involved in immune response
biological_process
OBSOLETE. The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
[ "GOC:add", "ISBN:0781735149" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "CD4-positive, alpha-beta T cell development involved in immune response", "CD4-positive, alpha-beta T cell differentiation during immune response", "CD4-positive, alpha-beta T lymphocyte differentiation during immune response", "CD4-positive, alpha-beta T-cell differentiation during immune response", "CD4-...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
3
GO:0002295
2,295
T-helper cell lineage commitment
biological_process
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T-helper cell fate commitment", "Th0 lineage commitment", "Thp lineage commitment" ]
[ "EXACT", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0043373" ]
[ "part_of GO:0042093" ]
[ "part_of" ]
[ "GO:0042093" ]
[ "GO:0042093", "GO:0043373" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002296
2,296
T-helper 1 cell lineage commitment
biological_process
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T-helper 1 cell fate commitment", "Th1 cell lineage commitment", "Th1 fate commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002295" ]
[ "part_of GO:0045063" ]
[ "part_of" ]
[ "GO:0045063" ]
[ "GO:0002295", "GO:0045063" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002297
2,297
T-helper 2 cell lineage commitment
biological_process
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and...
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T-helper 2 cell fate commitment", "Th2 fate commitment" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002295" ]
[ "part_of GO:0045064" ]
[ "part_of" ]
[ "GO:0045064" ]
[ "GO:0002295", "GO:0045064" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002298
2,298
obsolete CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
biological_process
OBSOLETE. The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.
[ "GOC:add", "PMID:12093005" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response", "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response", "CD4...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31306\" xsd:anyURI" ]
null
null
true
true
8
GO:0002299
2,299
alpha-beta intraepithelial T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "alpha-beta intraepithelial T cell development", "alpha-beta intraepithelial T lymphocyte differentiation", "alpha-beta intraepithelial T-cell differentiation", "alpha-beta intraepithelial T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0046632" ]
[]
[]
[]
[ "GO:0046632" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002300
2,300
CD8-positive, alpha-beta intraepithelial T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD8-positive, alpha-beta intraepithelial T cell development", "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation", "CD8-positive, alpha-beta intraepithelial T-cell differentiation", "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002299", "GO:0043374" ]
[]
[]
[]
[ "GO:0002299", "GO:0043374" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002301
2,301
CD4-positive, alpha-beta intraepithelial T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD4-positive, alpha-beta intraepithelial T cell development", "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation", "CD4-positive, alpha-beta intraepithelial T-cell differentiation", "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002299", "GO:0043367" ]
[]
[]
[]
[ "GO:0002299", "GO:0043367" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002302
2,302
CD8-positive, alpha-beta T cell differentiation involved in immune response
biological_process
The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD8-positive, alpha-beta intraepithelial T cell development", "CD8-positive, alpha-beta T cell differentiation during immune response", "CD8-positive, alpha-beta T lymphocyte differentiation during immune response", "CD8-positive, alpha-beta T-cell differentiation during immune response", "CD8-positive, al...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002287", "GO:0002292", "GO:0043374" ]
[]
[]
[]
[ "GO:0002287", "GO:0002292", "GO:0043374" ]
[ "GO:0043374", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002303
2,303
obsolete gamma-delta T cell differentiation involved in immune response
biological_process
OBSOLETE. The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
[ "GOC:add" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "gamma-delta T cell development involved in immune response", "gamma-delta T cell differentiation during immune response", "gamma-delta T lymphocyte differentiation during immune response", "gamma-delta T-cell differentiation during immune response", "gamma-delta T-lymphocyte differentiation during immune r...
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006955", "GO:0042492" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]
null
null
true
true
4
GO:0002304
2,304
gamma-delta intraepithelial T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "gamma-delta intraepithelial T cell development", "gamma-delta intraepithelial T lymphocyte differentiation", "gamma-delta intraepithelial T-cell differentiation", "gamma-delta intraepithelial T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0042492" ]
[]
[]
[]
[ "GO:0042492" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002306
2,306
CD4-positive gamma-delta intraepithelial T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD4-positive, gamma-delta intraepithelial T cell development", "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation", "CD4-positive, gamma-delta intraepithelial T-cell differentiation", "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002304" ]
[]
[]
[]
[ "GO:0002304" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002307
2,307
CD8-positive, alpha-beta regulatory T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD8-positive, alpha-beta regulatory T cell development", "CD8-positive, alpha-beta regulatory T lymphocyte differentiation", "CD8-positive, alpha-beta regulatory T-cell differentiation", "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043374", "GO:0045066" ]
[]
[]
[]
[ "GO:0043374", "GO:0045066" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002308
2,308
CD8-positive, alpha-beta cytotoxic T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD8-positive, alpha-beta cytotoxic T cell development", "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation", "CD8-positive, alpha-beta cytotoxic T-cell differentiation", "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043374", "GO:0045065" ]
[]
[]
[]
[ "GO:0043374", "GO:0045065" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002309
2,309
T cell proliferation involved in immune response
biological_process
The expansion of a T cell population by cell division as part of an immune response.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T cell proliferation during immune response", "T lymphocyte proliferation during immune response", "T-cell proliferation during immune response", "T-lymphocyte proliferation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002286", "GO:0042098" ]
[]
[]
[]
[ "GO:0002286", "GO:0042098" ]
[ "GO:0042098", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002310
2,310
obsolete alpha-beta T cell proliferation involved in immune response
biological_process
OBSOLETE. The expansion of an alpha-beta T cell population by cell division as part of an immune response.
[ "GOC:add", "ISBN:0781735149" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "alpha-beta T cell proliferation during immune response", "alpha-beta T lymphocyte proliferation during immune response", "alpha-beta T-cell proliferation during immune response", "alpha-beta T-lymphocyte proliferation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
3
GO:0002311
2,311
obsolete gamma-delta T cell proliferation involved in immune response
biological_process
OBSOLETE. The expansion of a gamma-delta T cell population by cell division as part of an immune response.
[ "GOC:add" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "gamma-delta T cell proliferation during immune response", "gamma-delta T lymphocyte proliferation during immune response", "gamma-delta T-cell proliferation during immune response", "gamma-delta T-lymphocyte proliferation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006955", "GO:0046630" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]
null
null
true
true
3
GO:0002312
2,312
B cell activation involved in immune response
biological_process
The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
[ "GOC:jal" ]
null
[ "B cell activation during immune response", "B lymphocyte activation during immune response", "B-cell activation during immune response", "B-lymphocyte activation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002285", "GO:0042113" ]
[]
[]
[]
[ "GO:0002285", "GO:0042113" ]
[ "GO:0042113", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002313
2,313
mature B cell differentiation involved in immune response
biological_process
The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
[ "GOC:jal" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "mature B cell development involved in immune response", "mature B cell differentiation during immune response", "mature B lymphocyte differentiation during immune response", "mature B-cell differentiation during immune response", "mature B-lymphocyte differentiation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002312", "GO:0002335" ]
[]
[]
[]
[ "GO:0002312", "GO:0002335" ]
[ "GO:0002335", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002314
2,314
germinal center B cell differentiation
biological_process
The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "germinal center B cell development", "germinal center B lymphocyte differentiation", "germinal center B-cell differentiation", "germinal center B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002315
2,315
marginal zone B cell differentiation
biological_process
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are...
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "marginal zone B cell development", "marginal zone B lymphocyte differentiation", "marginal zone B-cell differentiation", "marginal zone B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002316
2,316
follicular B cell differentiation
biological_process
The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "follicular B cell development", "follicular B lymphocyte differentiation", "follicular B-cell differentiation", "follicular B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002317
2,317
plasma cell differentiation
biological_process
The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
[ "GOC:jal" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "plasma cell development" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[ "GO:0002313" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002318
2,318
myeloid progenitor cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.
[ "GOC:add", "PMID:16551264" ]
null
[]
[]
[]
[]
[]
[ "GO:0002244" ]
[]
[]
[]
[ "GO:0002244" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002319
2,319
memory B cell differentiation
biological_process
The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "memory B cell development", "memory B lymphocyte differentiation", "memory B-cell differentiation", "memory B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002313", "GO:0090715" ]
[]
[]
[]
[ "GO:0002313", "GO:0090715" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002320
2,320
lymphoid progenitor cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.
[ "GOC:add", "PMID:16551251", "PMID:16551264" ]
null
[]
[]
[]
[]
[]
[ "GO:0002244" ]
[]
[]
[]
[ "GO:0002244" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002321
2,321
natural killer cell progenitor differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.
[ "GOC:add", "PMID:16551251", "PMID:16551264" ]
null
[]
[]
[]
[]
[]
[ "GO:0002320" ]
[]
[]
[]
[ "GO:0002320" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002322
2,322
B cell proliferation involved in immune response
biological_process
The expansion of a B cell population by cell division following B cell activation during an immune response.
[ "GOC:jal" ]
null
[ "B cell proliferation during immune response", "B lymphocyte proliferation during immune response", "B-cell proliferation during immune response", "B-lymphocyte proliferation during immune response" ]
[ "RELATED", "RELATED", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002312", "GO:0042100" ]
[]
[]
[]
[ "GO:0002312", "GO:0042100" ]
[ "GO:0042100", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002323
2,323
natural killer cell activation involved in immune response
biological_process
The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
[ "GOC:add", "PMID:15032583" ]
null
[ "natural killer cell activation during immune response", "NK cell activation during immune response" ]
[ "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002285", "GO:0030101" ]
[ "part_of GO:0045087" ]
[ "part_of" ]
[ "GO:0045087" ]
[ "GO:0002285", "GO:0030101", "GO:0045087" ]
[ "GO:0030101", "part_of GO:0045087" ]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002324
2,324
obsolete natural killer cell proliferation involved in immune response
biological_process
OBSOLETE. The expansion of a natural killer cell population by cell division as part of an immune response.
[ "GOC:add", "PMID:15032583" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "natural killer cell proliferation during immune response", "NK cell proliferation during immune response" ]
[ "RELATED", "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31306\" xsd:anyURI" ]
null
null
true
true
5
GO:0002326
2,326
B cell lineage commitment
biological_process
The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "B lymphocyte lineage commitment", "B-cell lineage commitment", "B-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0045165" ]
[ "part_of GO:0030183" ]
[ "part_of" ]
[ "GO:0030183" ]
[ "GO:0030183", "GO:0045165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002327
2,327
immature B cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of an immature B cell.
[ "GOC:jal", "ISBN:0781735149", "PMID:16551251" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "immature B cell development", "immature B lymphocyte differentiation", "immature B-cell differentiation", "immature B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0030183" ]
[]
[]
[]
[ "GO:0030183" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002329
2,329
pre-B cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "pre-B cell development", "pre-B lymphocyte differentiation" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0002327" ]
[]
[]
[]
[ "GO:0002327" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002330
2,330
pre-B cell receptor expression
biological_process
The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-...
[ "GOC:add", "GOC:jal", "PMID:15263090", "PMID:22949502", "PMID:9834086" ]
null
[]
[]
[]
[]
[]
[ "GO:0048869" ]
[ "part_of GO:0002329" ]
[ "part_of" ]
[ "GO:0002329" ]
[ "GO:0002329", "GO:0048869" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002331
2,331
pre-B cell allelic exclusion
biological_process
Expression of a single heavy chain allele during pre-B cell differentiation.
[ "GOC:add", "GOC:jal", "ISBN:0781735149" ]
null
[ "pre-B lymphocyte allelic exclusion" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0010468" ]
[ "part_of GO:0002329" ]
[ "part_of" ]
[ "GO:0002329" ]
[ "GO:0002329", "GO:0010468" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0002332
2,332
transitional stage B cell differentiation
biological_process
The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "transitional stage B cell development", "transitional stage B lymphocyte differentiation", "transitional stage B-cell differentiation", "transitional stage B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002327" ]
[]
[]
[]
[ "GO:0002327" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002333
2,333
transitional one stage B cell differentiation
biological_process
The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "T1 stage B cell differentiation", "transitional one stage B cell development", "transitional one stage B lymphocyte differentiation", "transitional one stage B-cell differentiation", "transitional one stage B-lymphocyte differentiation" ]
[ "EXACT", "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002332" ]
[]
[]
[]
[ "GO:0002332" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002334
2,334
transitional two stage B cell differentiation
biological_process
The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "T2 stage B cell differentiation", "transitional two stage B cell development", "transitional two stage B lymphocyte differentiation", "transitional two stage B-cell differentiation", "transitional two stage B-lymphocyte differentiation" ]
[ "EXACT", "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002332" ]
[]
[]
[]
[ "GO:0002332" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002335
2,335
mature B cell differentiation
biological_process
The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "mature B lymphocyte differentiation", "mature B-cell differentiation", "mature B-lymphocyte differentiation", "mature cell development" ]
[ "EXACT", "EXACT", "EXACT", "RELATED" ]
[]
[]
[]
[ "GO:0030183" ]
[]
[]
[]
[ "GO:0030183" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002336
2,336
B-1 B cell lineage commitment
biological_process
The process in which an immature B cell becomes committed to become a B-1 B cell.
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "B-1 B lymphocyte lineage commitment", "B-1 B-cell lineage commitment", "B-1 B-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002326" ]
[ "part_of GO:0001923" ]
[ "part_of" ]
[ "GO:0001923" ]
[ "GO:0001923", "GO:0002326" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002337
2,337
B-1a B cell differentiation
biological_process
The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "B-1a B cell development", "B-1a B lymphocyte differentiation", "B-1a B-cell differentiation", "B-1a B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0001923" ]
[]
[]
[]
[ "GO:0001923" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002338
2,338
B-1b B cell differentiation
biological_process
The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.
[ "GOC:jal", "ISBN:0781735149" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "B-1b B cell development", "B-1b B lymphocyte differentiation", "B-1b B-cell differentiation", "B-1b B-lymphocyte differentiation" ]
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0001923" ]
[]
[]
[]
[ "GO:0001923" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002339
2,339
B cell selection
biological_process
The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
[ "GOC:jal" ]
null
[ "B lymphocyte selection", "B-cell selection", "B-lymphocyte selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002376" ]
[ "part_of GO:0030183" ]
[ "part_of" ]
[ "GO:0030183" ]
[ "GO:0002376", "GO:0030183" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002340
2,340
central B cell selection
biological_process
Any B cell selection process that occurs in the bone marrow.
[ "GOC:jal" ]
null
[ "central B lymphocyte selection", "central B-cell selection", "central B-lymphocyte selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002342
2,342
central B cell deletion
biological_process
The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.
[ "GOC:add", "GOC:jal", "GOC:mtg_apoptosis" ]
null
[ "central B lymphocyte deletion", "central B-cell deletion", "central B-lymphocyte deletion" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002516", "GO:0010623" ]
[ "part_of GO:0002340", "part_of GO:0002510" ]
[ "part_of", "part_of" ]
[ "GO:0002340", "GO:0002510" ]
[ "GO:0002340", "GO:0002510", "GO:0002516", "GO:0010623" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002343
2,343
peripheral B cell selection
biological_process
Any B cell selection process that occurs in the periphery.
[ "GOC:jal" ]
null
[ "peripheral B lymphocyte selection", "peripheral B-cell selection", "peripheral B-lymphocyte selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002344
2,344
B cell affinity maturation
biological_process
The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
[ "GO_REF:0000022", "GOC:jal", "ISBN:0781735149" ]
null
[ "B lymphocyte affinity maturation", "B-cell affinity maturation", "B-lymphocyte affinity maturation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002343" ]
[ "part_of GO:0002381" ]
[ "part_of" ]
[ "GO:0002381" ]
[ "GO:0002343", "GO:0002381" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002345
2,345
peripheral B cell receptor editing
biological_process
The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.
[ "GOC:jal" ]
null
[ "peripheral B lymphocyte receptor editing", "peripheral B-cell receptor editing", "peripheral B-lymphocyte receptor editing" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002452" ]
[]
[]
[]
[ "GO:0002452" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002349
2,349
histamine production involved in inflammatory response
biological_process
The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
[ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
null
[ "histamine production involved in acute inflammatory response" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0002532" ]
[]
[]
[]
[ "GO:0002532" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002350
2,350
peripheral B cell positive selection
biological_process
Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.
[ "GOC:jal" ]
null
[ "peripheral B lymphocyte positive selection", "peripheral B-cell positive selection", "peripheral B-lymphocyte positive selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002343", "GO:0002346" ]
[]
[]
[]
[ "GO:0002343", "GO:0002346" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002351
2,351
serotonin production involved in inflammatory response
biological_process
The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
[ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
null
[ "serotonin production involved in acute inflammatory response" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0002532" ]
[]
[]
[]
[ "GO:0002532" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002352
2,352
B cell negative selection
biological_process
Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.
[ "GOC:jal" ]
null
[ "B lymphocyte negative selection", "B-cell negative selection", "B-lymphocyte negative selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[ "GO:0002339" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002353
2,353
plasma kallikrein-kinin cascade
biological_process
A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininog...
[ "GOC:add", "ISBN:0721601871", "PMID:11842287", "PMID:14501145" ]
null
[]
[]
[]
[]
[]
[ "GO:0002254" ]
[]
[]
[]
[ "GO:0002254" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002354
2,354
central B cell negative selection
biological_process
Any process leading to negative selection of B cells in the bone marrow.
[ "GOC:jal" ]
null
[ "central B lymphocyte negative selection", "central B-cell negative selection", "central B-lymphocyte negative selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002340", "GO:0002352" ]
[]
[]
[]
[ "GO:0002340", "GO:0002352" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002355
2,355
detection of tumor cell
biological_process
The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.
[ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
null
[]
[]
[]
[]
[]
[ "GO:0002347", "GO:0009595" ]
[]
[]
[]
[ "GO:0002347", "GO:0009595" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002356
2,356
peripheral B cell negative selection
biological_process
Any process leading to negative selection of B cells in the periphery.
[ "GOC:jal" ]
null
[ "peripheral B lymphocyte negative selection", "peripheral B-cell negative selection", "peripheral B-lymphocyte negative selection" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002343", "GO:0002352" ]
[]
[]
[]
[ "GO:0002343", "GO:0002352" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002357
2,357
defense response to tumor cell
biological_process
Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
[ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
null
[]
[]
[]
[]
[]
[ "GO:0002347", "GO:0006952" ]
[]
[]
[]
[ "GO:0002347", "GO:0006952" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002360
2,360
T cell lineage commitment
biological_process
The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "T lymphocyte lineage commitment", "T-cell lineage commitment", "T-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0045165" ]
[ "part_of GO:0030217" ]
[ "part_of" ]
[ "GO:0030217" ]
[ "GO:0030217", "GO:0045165" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002361
2,361
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
biological_process
The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
[ "GOC:add", "PMID:15207821" ]
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
[ "CD4-positive, CD25-positive, alpha-beta regulatory T cell development", "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation", "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiat...
[ "RELATED", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043367", "GO:0045066" ]
[]
[]
[]
[ "GO:0043367", "GO:0045066" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002362
2,362
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
biological_process
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
[ "GOC:add", "PMID:15207821" ]
null
[ "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment", "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment", "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0043373" ]
[ "part_of GO:0002361" ]
[ "part_of" ]
[ "GO:0002361" ]
[ "GO:0002361", "GO:0043373" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002363
2,363
alpha-beta T cell lineage commitment
biological_process
The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "alpha-beta T lymphocyte lineage commitment", "alpha-beta T-cell lineage commitment", "alpha-beta T-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002360" ]
[ "part_of GO:0046632" ]
[ "part_of" ]
[ "GO:0046632" ]
[ "GO:0002360", "GO:0046632" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0002364
2,364
NK T cell lineage commitment
biological_process
The process in which a pro-T cell becomes committed to becoming an NK T cell.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "natural killer T lymphocyte lineage commitment", "natural killer T-cell lineage commitment", "natural killer T-lymphocyte lineage commitment", "NK T lymphocyte lineage commitment", "NK T-cell lineage commitment", "NK T-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002363" ]
[ "part_of GO:0001865" ]
[ "part_of" ]
[ "GO:0001865" ]
[ "GO:0001865", "GO:0002363" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0002365
2,365
gamma-delta T cell lineage commitment
biological_process
The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.
[ "GOC:add", "ISBN:0781735149" ]
null
[ "gamma-delta T lymphocyte lineage commitment", "gamma-delta T-cell lineage commitment", "gamma-delta T-lymphocyte lineage commitment" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0002360" ]
[ "part_of GO:0042492" ]
[ "part_of" ]
[ "GO:0042492" ]
[ "GO:0002360", "GO:0042492" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002367
2,367
cytokine production involved in immune response
biological_process
The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
[ "GO_REF:0000022", "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "cytokine biosynthetic process involved in immune response", "cytokine production during immune response", "cytokine secretion during immune response", "cytokine secretion involved in immune response" ]
[ "NARROW", "RELATED", "RELATED", "RELATED" ]
[ "GO:0002374", "GO:0002375" ]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0001816", "GO:0002440" ]
[ "part_of GO:0006955" ]
[ "part_of" ]
[ "GO:0006955" ]
[ "GO:0001816", "GO:0002440", "GO:0006955" ]
[ "GO:0001816", "part_of GO:0006955" ]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0002368
2,368
B cell cytokine production
biological_process
Any process that contributes to cytokine production by a B cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "B lymphocyte cytokine production", "B-cell cytokine production", "B-lymphocyte cytokine production" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002367", "GO:0019724" ]
[]
[]
[]
[ "GO:0002367", "GO:0019724" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002369
2,369
T cell cytokine production
biological_process
Any process that contributes to cytokine production by a T cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "T lymphocyte cytokine production", "T-cell cytokine production", "T-lymphocyte cytokine production" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002367", "GO:0002456" ]
[]
[]
[]
[ "GO:0002367", "GO:0002456" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002370
2,370
natural killer cell cytokine production
biological_process
Any process that contributes to cytokine production by a natural killer cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "NK cell cytokine production" ]
[ "EXACT" ]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002228", "GO:0002367" ]
[]
[]
[]
[ "GO:0002228", "GO:0002367" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002372
2,372
myeloid dendritic cell cytokine production
biological_process
Any process that contributes to cytokine production by a myeloid dendritic cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[]
[]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002371", "GO:0002444", "GO:0061082" ]
[]
[]
[]
[ "GO:0002371", "GO:0002444", "GO:0061082" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002373
2,373
plasmacytoid dendritic cell cytokine production
biological_process
Any process that contributes to cytokine production by a plasmacytoid dendritic cell.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[]
[]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002371" ]
[]
[]
[]
[ "GO:0002371" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002376
2,376
immune system process
biological_process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
[ "GO_REF:0000022", "GOC:add" ]
Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
[]
[]
[]
[ "goslim_agr", "goslim_chembl", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_pir" ]
[ "Wikipedia:Immune_system" ]
[ "GO:0008150" ]
[]
[]
[]
[ "GO:0008150" ]
[]
[]
[ "GO:0044848" ]
[]
[]
[]
null
null
false
true
2
GO:0002377
2,377
immunoglobulin production
biological_process
The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
[ "GOC:add", "ISBN:0781735149" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "antibody production", "immunoglobulin biosynthetic process", "immunoglobulin secretion" ]
[ "EXACT", "NARROW", "NARROW" ]
[ "GO:0002378", "GO:0048305" ]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002440" ]
[]
[]
[]
[ "GO:0002440" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002381
2,381
immunoglobulin production involved in immunoglobulin-mediated immune response
biological_process
The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
[ "GOC:add", "ISBN:0781735149", "PMID:9185563" ]
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
[ "antibody production during immune response", "antibody secretion during immune response", "immunoglobulin biosynthetic process involved in immune response", "immunoglobulin production during immune response", "immunoglobulin production involved in immune response", "immunoglobulin production involved in ...
[ "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "EXACT", "NARROW" ]
[ "GO:0002379", "GO:0002380" ]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0002377" ]
[ "part_of GO:0016064" ]
[ "part_of" ]
[ "GO:0016064" ]
[ "GO:0002377", "GO:0016064" ]
[ "GO:0002377", "part_of GO:0016064" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002382
2,382
regulation of tissue kallikrein-kinin cascade
biological_process
Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.
[ "GOC:add" ]
null
[ "regulation of glandular kallikrein-kinin cascade" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002256" ]
[ "regulates GO:0002255" ]
[ "regulates" ]
[ "GO:0002255" ]
[ "GO:0002255", "GO:0002256" ]
[ "GO:0065007", "regulates GO:0002255" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002383
2,383
immune response in brain or nervous system
biological_process
An immune response taking place in the brain or nervous system.
[ "GO_REF:0000022", "GOC:jal", "ISBN:0781735149" ]
null
[]
[]
[]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0002384
2,384
hepatic immune response
biological_process
An immune response taking place in the liver.
[ "GO_REF:0000022", "GOC:jal", "ISBN:0781735149" ]
null
[]
[]
[]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0002385
2,385
mucosal immune response
biological_process
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
[ "GO_REF:0000022", "GOC:jal", "ISBN:0781735149" ]
null
[ "immune response in MALT", "immune response in mucosal-associated lymphoid tissue", "immune response in urogenital tract" ]
[ "NARROW", "NARROW", "NARROW" ]
[ "GO:0002386", "GO:0002422" ]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[ "GO:0002251" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002387
2,387
immune response in gut-associated lymphoid tissue
biological_process
Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "immune response in GALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0006955" ]
[]
[]
[]
[ "GO:0006955" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002388
2,388
immune response in Peyer's patch
biological_process
Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.
[ "GOC:jal", "ISBN:0781735149" ]
null
[]
[]
[]
[]
[]
[ "GO:0002387" ]
[]
[]
[]
[ "GO:0002387" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0002389
2,389
tolerance induction in Peyer's patch
biological_process
Tolerance induction taking place in the Peyer's patches.
[ "GOC:jal", "ISBN:0781735149" ]
null
[]
[]
[]
[]
[]
[ "GO:0002388", "GO:0002394" ]
[]
[]
[]
[ "GO:0002388", "GO:0002394" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002391
2,391
obsolete platelet activating factor production involved in inflammatory response
biological_process
OBSOLETE. The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
[ "GOC:add", "ISBN:0781735149" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "platelet activating factor production", "platelet activating factor production involved in acute inflammatory response", "platelet activating factor secretion", "platelet activating factor secretion involved in acute inflammatory response", "platelet activating factor secretion involved in inflammatory res...
[ "RELATED", "NARROW", "NARROW", "NARROW", "NARROW" ]
[ "GO:0002390", "GO:0002392", "GO:0002535" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0002532", "GO:000666" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20154\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI" ]
null
null
true
true
3
GO:0002393
2,393
obsolete lysosomal enzyme production involved in inflammatory response
biological_process
OBSOLETE. The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.
[ "GOC:add" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "lysosomal enzyme production involved in acute inflammatory response", "production of lysosomal enzymes involved in acute inflammatory response", "production of lysosomal enzymes involved in inflammatory response" ]
[ "BROAD", "BROAD", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31306\" xsd:anyURI" ]
null
null
true
true
1
GO:0002394
2,394
tolerance induction in gut-associated lymphoid tissue
biological_process
Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "oral tolerance", "tolerance induction in GALT" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0002387", "GO:0002401" ]
[]
[]
[]
[ "GO:0002387", "GO:0002401" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0002395
2,395
immune response in nasopharyngeal-associated lymphoid tissue
biological_process
An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "immune response in NALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002387" ]
[]
[]
[]
[ "GO:0002387" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002396
2,396
MHC protein complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.
[ "GOC:add", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ]
null
[]
[]
[]
[]
[]
[ "GO:0065003" ]
[]
[]
[]
[ "GO:0065003" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002397
2,397
MHC class I protein complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.
[ "GOC:add", "ISBN:0781735149", "PMID:15771591" ]
null
[]
[]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002398
2,398
MHC class Ib protein complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.
[ "GOC:add", "PMID:15928678", "PMID:15928680" ]
null
[]
[]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002399
2,399
MHC class II protein complex assembly
biological_process
The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.
[ "GOC:add", "ISBN:0781735149", "PMID:15771591" ]
null
[]
[]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[ "GO:0002396" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0002400
2,400
tolerance induction in nasopharyngeal-associated lymphoid tissue
biological_process
Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "nasal tolerance", "tolerance induction in NALT" ]
[ "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0002394", "GO:0002395" ]
[]
[]
[]
[ "GO:0002394", "GO:0002395" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0002401
2,401
tolerance induction in mucosal-associated lymphoid tissue
biological_process
Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "tolerance induction in MALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002427" ]
[]
[]
[]
[ "GO:0002427" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0002402
2,402
B cell tolerance induction in mucosal-associated lymphoid tissue
biological_process
Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.
[ "GOC:jal", "ISBN:0781735149" ]
null
[ "B cell tolerance induction in MALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002401", "GO:0002451" ]
[]
[]
[]
[ "GO:0002401", "GO:0002451" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002403
2,403
T cell tolerance induction in mucosal-associated lymphoid tissue
biological_process
Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.
[ "GOC:jal", "ISBN:0781735149", "PMID:16551263" ]
null
[ "T cell tolerance induction in MALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002401", "GO:0002458" ]
[]
[]
[]
[ "GO:0002401", "GO:0002458" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0002404
2,404
antigen sampling in mucosal-associated lymphoid tissue
biological_process
The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.
[ "GOC:jal", "PMID:11896763", "PMID:12843411", "PMID:15681746" ]
null
[ "antigen sampling in MALT", "antigen transport in MALT", "antigen transport in mucosal-associated lymphoid tissue" ]
[ "EXACT", "RELATED", "RELATED" ]
[]
[]
[]
[ "GO:0002376" ]
[ "part_of GO:0002385" ]
[ "part_of" ]
[ "GO:0002385" ]
[ "GO:0002376", "GO:0002385" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0002405
2,405
antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
biological_process
The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.
[ "GOC:jal", "PMID:11896763", "PMID:15681746" ]
null
[ "antigen sampling by dendritic cells in MALT" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0002404" ]
[ "part_of GO:0002468" ]
[ "part_of" ]
[ "GO:0002468" ]
[ "GO:0002404", "GO:0002468" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7