LiteFold/GO · Datasets at Hugging Face

GO:0003695

3,695

obsolete random coil DNA binding

molecular_function

OBSOLETE. Binding to DNA in a random coil configuration.

[ "GOC:mah" ]

This term was obsoleted because the definition was not clear enough as to what is directing specificity of the binding to the DNA.

[ "random coil binding" ]

[ "EXACT" ]

[ "GO:0016017" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18879\" xsd:anyURI" ]

null

true

6

GO:0003696

3,696

satellite DNA binding

molecular_function

Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.

[ "GOC:jl", "SO:0000005" ]

null

[]

[ "GO:1990837" ]

[]

[ "GO:1990837" ]

[]

null

false

true

9

GO:0003697

3,697

single-stranded DNA binding

molecular_function

Binding to single-stranded DNA.

[ "GOC:elh", "GOC:vw", "PMID:22976174" ]

Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA.

[ "ssDNA binding" ]

[ "EXACT" ]

[ "GO:0003698", "GO:0003699" ]

[]

[ "GO:0003677" ]

[]

[ "GO:0003677" ]

[]

null

false

true

2

GO:0003700

3,700

DNA-binding transcription factor activity

molecular_function

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are tr...

[ "GOC:txnOH-2018" ]

Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protei...

[ "bacterial-type DNA binding transcription factor activity", "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity", "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity", "bacterial-...

[ "NARROW", "NARROW", "NARROW", "NARROW", "NARROW", "EXACT", "EXACT", "NARROW", "NARROW", "BROAD", "NARROW", "EXACT", "BROAD", "NARROW", "NARROW", "NARROW", "NARROW" ]

[ "GO:0000130", "GO:0001071", "GO:0001130", "GO:0001131", "GO:0001151", "GO:0001199", "GO:0001204" ]

[ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_metagenomics", "goslim_mouse", "goslim_plant", "goslim_yeast" ]

[ "Reactome:R-HSA-163666 \"Formation of ChREBP:MLX heterodimer\"" ]

[ "GO:0140110" ]

[ "has_part GO:0000976", "part_of GO:0006355" ]

[ "has_part", "part_of" ]

[ "GO:0000976", "GO:0006355" ]

[ "GO:0000976", "GO:0006355", "GO:0140110" ]

[ "GO:0140110", "has_part GO:0000976", "part_of GO:0006355" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15704\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16534\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20253\" xsd:anyURI" ]

krc

2010-10-21T04:37:54Z

false

true

9

GO:0003701

3,701

obsolete RNA polymerase I transcription factor activity

molecular_function

OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription.

[ "GOC:jl" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "RNA polymerase I transcription factor activity" ]

[ "EXACT" ]

[]

[ "GO:0001181", "GO:0006360" ]

[]

null

true

2

GO:0003702

3,702

obsolete RNA polymerase II transcription factor activity

molecular_function

OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.

[ "GOC:jl" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "RNA polymerase II transcription factor activity" ]

[ "EXACT" ]

[]

[ "GO:0000981", "GO:0006366" ]

[]

null

true

2

GO:0003704

3,704

obsolete specific RNA polymerase II transcription factor activity

molecular_function

OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.

[ "GOC:ma" ]

This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Bio...

[ "specific RNA polymerase II transcription factor activity" ]

[ "EXACT" ]

[]

[ "GO:0000981", "GO:0006366" ]

[]

null

true

5

GO:0003707

3,707

nuclear steroid receptor activity

molecular_function

A nuclear receptor activity regulated by steroid binding and modulating the transcription of specific gene sets transcribed by RNA polymerase II.

[ "GOC:signaling", "PMID:14708019" ]

null

[ "steroid hormone receptor activity" ]

[ "BROAD" ]

[]

[ "Reactome:R-HSA-8963915 \"1,25(OH)2D binds VDR\"" ]

[ "GO:0004879" ]

[ "part_of GO:0030518" ]

[ "part_of" ]

[ "GO:0030518" ]

[ "GO:0004879", "GO:0030518" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16717\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26957\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29150\" xsd:anyURI" ]

null

false

true

7

GO:0003709

3,709

obsolete RNA polymerase III transcription factor activity

molecular_function

OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription.

[ "GOC:jl" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "RNA polymerase III transcription factor activity" ]

[ "EXACT" ]

[]

[ "GO:0000995", "GO:0006383" ]

[]

null

true

5

GO:0003711

3,711

transcription elongation factor activity

molecular_function

A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.

[ "GOC:txnOH-2018", "PMID:23878398", "PMID:28892040" ]

Restored term from obsolete.

[ "transcription elongation regulator activity", "transcriptional elongation regulator activity" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0140110" ]

[]

[ "GO:0140110" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14398\" xsd:anyURI" ]

null

false

true

1

GO:0003712

3,712

transcription coregulator activity

molecular_function

A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcri...

[ "GOC:txnOH-2018", "PMID:10213677", "PMID:16858867", "PMID:24203923", "PMID:25957681", "Wikipedia:Transcription_coregulator" ]

Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.

[ "nuclear receptor coreceptor activity", "RNA polymerase II transcriptional cofactor activity", "transcription cofactor activity", "transcription coreceptor activity", "transcriptional co-regulator" ]

[ "NARROW", "RELATED", "EXACT", "EXACT", "EXACT" ]

[ "GO:0001104", "GO:0016455" ]

[ "goslim_drosophila" ]

[ "Reactome:R-HSA-5340251 \"NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2\"" ]

[ "GO:0140110" ]

[]

[ "GO:0140110" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15536\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15665\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15998\" xsd:anyURI", "term_tracker_item \"https://gi...

krc

2010-11-24T03:02:15Z

false

true

9

GO:0003713

3,713

transcription coactivator activity

molecular_function

A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one cl...

[ "GOC:txnOH-2018", "PMID:10213677", "PMID:16858867" ]

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

[ "RNA polymerase II transcription co-activator activity", "RNA polymerase II transcription coactivator activity", "RNA polymerase II transcription mediator activity", "transcription co-activator activity" ]

[ "RELATED", "RELATED", "RELATED", "EXACT" ]

[ "GO:0001105" ]

[]

[ "GO:0003712" ]

[ "part_of GO:0045893" ]

[ "part_of" ]

[ "GO:0045893" ]

[ "GO:0003712", "GO:0045893" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15665\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15998\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20253\" xsd:anyURI", "term_tracker_item \"https://gi...

krc

2010-11-24T03:08:19Z

false

true

4

GO:0003714

3,714

transcription corepressor activity

molecular_function

A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one cl...

[ "GOC:txnOH-2018", "PMID:10213677", "PMID:16858867" ]

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

[ "RNA polymerase II transcription co-repressor activity", "RNA polymerase II transcription corepressor activity", "transcription co-repressor activity" ]

[ "RELATED", "RELATED", "EXACT" ]

[ "GO:0001106" ]

[]

[ "Reactome:R-HSA-400183 \"PPARA:RXRA binds Corepressors of PPARA\"" ]

[ "GO:0003712" ]

[ "part_of GO:0045892" ]

[ "part_of" ]

[ "GO:0045892" ]

[ "GO:0003712", "GO:0045892" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15665\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15998\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20464\" xsd:anyURI", "term_tracker_item \"https://gi...

krc

2010-11-24T03:14:44Z

false

true

6

GO:0003715

3,715

obsolete transcription termination factor activity

molecular_function

OBSOLETE. Any activity that brings about termination of transcription.

[ "GOC:mah" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "transcription termination factor activity", "transcriptional termination factor activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006353" ]

[]

null

true

1

GO:0003716

3,716

obsolete RNA polymerase I transcription termination factor activity

molecular_function

OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I.

[ "GOC:mah" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "Pol I transcription termination factor activity", "RNA polymerase I transcription termination factor activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006363" ]

[]

null

true

8

GO:0003717

3,717

obsolete RNA polymerase II transcription termination factor activity

molecular_function

OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II.

[ "GOC:mah" ]

This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the fun...

[ "Pol II transcription termination factor activity", "RNA polymerase II transcription termination factor activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006369" ]

[]

null

true

1

GO:0003719

3,719

obsolete transcription factor binding, cytoplasmic sequestering

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because sequestering is a process rather than a function.

[ "transcription factor binding, cytoplasmic sequestering" ]

[ "EXACT" ]

[]

null

true

5

GO:0003720

3,720

telomerase activity

molecular_function

Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) using an internal RNA template that encodes the telomeric repeat sequence.

[ "GOC:krc", "PMID:11812242", "PMID:28732250" ]

null

[ "telomerase RNA reverse transcriptase activity", "telomerase, catalyst" ]

[ "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-163090 \"Elongation Of The Telomeric Chromosome End\"", "Reactome:R-HSA-164617 \"Elongation of Extended Telomeric Chromosome End\"" ]

[ "GO:0003964" ]

[]

[ "GO:0003964" ]

[]

[ "skos:broadMatch EC:2.7.7.49", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28394\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28520\" xsd:anyURI" ]

null

false

true

9

GO:0003721

3,721

obsolete telomerase RNA reverse transcriptase activity

molecular_function

OBSOLETE. Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.

[ "PMID:11812242" ]

This term was obsoleted because it represents the same activity as telomerase activity ; GO:0003720.

[ "telomerase, catalyst" ]

[ "EXACT" ]

[]

[ "GO:0003720" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28394\" xsd:anyURI" ]

null

true

9

GO:0003723

3,723

RNA binding

molecular_function

Binding to an RNA molecule or a portion thereof.

[ "GOC:jl", "GOC:mah" ]

null

[ "base pairing with RNA", "poly(A) RNA binding", "poly(A)-RNA binding", "poly-A RNA binding" ]

[ "NARROW", "RELATED", "RELATED", "RELATED" ]

[ "GO:0000498", "GO:0044822" ]

[ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_flybase_ribbon", "goslim_generic", "goslim_mouse", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon", "goslim_yeast" ]

[ "Reactome:R-HSA-203922 \"Exportin-5 recognizes 3' overhang of pre-miRNA\"" ]

[ "GO:0003676" ]

[]

[ "GO:0003676" ]

[]

null

false

true

4

GO:0003724

3,724

RNA helicase activity

molecular_function

Unwinding of an RNA helix, driven by ATP hydrolysis.

[ "GOC:jl", "PMID:19158098" ]

null

[ "ATP-dependent RNA helicase activity" ]

[ "EXACT" ]

[ "GO:0004004" ]

[]

[ "EC:3.6.4.13", "MetaCyc:RXN-11109", "Reactome:R-HSA-72647 \"Cap-bound mRNA is activated by helicases\"", "Reactome:R-HSA-9770129 \"Formation of the Spliceosomal A complex\"", "Reactome:R-HSA-9770131 \"Formation of the Spliceosomal B* complex\"", "Reactome:R-HSA-9770141 \"Formation of the Spliceosomal C* c...

[ "GO:0004386", "GO:0008186", "GO:0140098" ]

[]

[ "GO:0004386", "GO:0008186", "GO:0140098" ]

[]

[ "skos:exactMatch EC:3.6.4.13", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21612\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

8

GO:0003725

3,725

double-stranded RNA binding

molecular_function

Binding to double-stranded RNA.

[ "GOC:jl" ]

null

[ "dsRNA binding" ]

[ "EXACT" ]

[]

[ "GO:0003723" ]

[]

[ "GO:0003723" ]

[]

null

false

true

3

GO:0003726

3,726

double-stranded RNA adenosine deaminase activity

molecular_function

Catalysis of the reaction: adenosine + H2O = inosine + NH4+, in a double-stranded RNA molecule.

[ "GOC:mah", "RHEA:10120" ]

null

[ "double-stranded RNA specific editase activity" ]

[ "RELATED" ]

[ "GO:0003971" ]

[]

[ "EC:3.5.4.37", "Reactome:R-HSA-77614 \"Deamination at C6 position of adenosine in Editosome (ADAR1)\"", "Reactome:R-HSA-77615 \"Deamination at C6 position of adenosine in Editosome (ADAR2)\"", "RHEA:10120" ]

[ "GO:0019239" ]

[]

[ "GO:0019239" ]

[]

[ "skos:exactMatch EC:3.5.4.37", "skos:exactMatch RHEA:10120", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24880\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0003727

3,727

single-stranded RNA binding

molecular_function

Binding to single-stranded RNA.

[ "GOC:jl" ]

null

[ "ssRNA binding" ]

[ "EXACT" ]

[ "GO:0003728" ]

[]

[ "GO:0003723" ]

[]

[ "GO:0003723" ]

[]

null

false

true

3

GO:0003729

3,729

mRNA binding

molecular_function

Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

[ "GOC:kmv", "GOC:pr", "SO:0000234" ]

null

[ "base pairing with mRNA" ]

[ "NARROW" ]

[ "GO:0000499" ]

[ "goslim_chembl", "goslim_yeast" ]

[]

[ "GO:0003723" ]

[]

[ "GO:0003723" ]

[]

null

false

true

5

GO:0003730

3,730

mRNA 3'-UTR binding

molecular_function

Binding to a 3' untranslated region of an mRNA molecule.

[ "GOC:mah" ]

null

[ "mRNA 3' UTR binding" ]

[ "EXACT" ]

[]

[ "GO:0003729" ]

[]

[ "GO:0003729" ]

[]

null

false

true

2

GO:0003731

3,731

obsolete mRNA cap binding

molecular_function

OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript.

[ "GOC:mah" ]

This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.

[ "mRNA cap binding" ]

[ "EXACT" ]

[]

[ "GO:0000339" ]

[]

null

true

9

GO:0003732

3,732

obsolete snRNA cap binding

molecular_function

OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule.

[ "GOC:mah" ]

This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.

[ "snRNA cap binding" ]

[ "EXACT" ]

[]

[ "GO:0000339" ]

[]

null

true

3

GO:0003733

3,733

obsolete ribonucleoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it describes a cellular component rather than a molecular function.

[ "ribonucleoprotein" ]

[ "EXACT" ]

[]

[ "GO:1990904" ]

[]

null

true

4

GO:0003734

3,734

obsolete small nuclear ribonucleoprotein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it describes a cellular component rather than a molecular function.

[ "small nuclear ribonucleoprotein", "snRNP" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0030532" ]

[]

null

true

8

GO:0003735

3,735

structural constituent of ribosome

molecular_function

The action of a molecule that contributes to the structural integrity of the ribosome.

[ "GOC:mah" ]

Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.

[ "ribosomal protein", "ribosomal RNA" ]

[ "BROAD", "RELATED" ]

[ "GO:0003736", "GO:0003737", "GO:0003738", "GO:0003739", "GO:0003740", "GO:0003741", "GO:0003742" ]

[ "goslim_chembl", "goslim_drosophila", "goslim_metagenomics", "goslim_yeast" ]

[]

[ "GO:0005198" ]

[ "occurs_in GO:0005840" ]

[ "occurs_in" ]

[ "GO:0005840" ]

[ "GO:0005198", "GO:0005840" ]

[ "GO:0005198", "occurs_in GO:0005840" ]

[]

null

false

true

8

GO:0003743

3,743

translation initiation factor activity

molecular_function

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

[ "ISBN:0198506732" ]

null

[]

[ "GO:0003744", "GO:0003745" ]

[]

[ "Reactome:R-HSA-72621 \"Ribosomal scanning\"", "Reactome:R-HSA-72697 \"Start codon recognition\"", "Reactome:R-HSA-72722 \"eIF2 activation\"" ]

[ "GO:0180051" ]

[ "part_of GO:0006413" ]

[ "part_of" ]

[ "GO:0006413" ]

[ "GO:0006413", "GO:0180051" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29089\" xsd:anyURI" ]

null

false

true

2

GO:0003746

3,746

translation elongation factor activity

molecular_function

Functions in chain elongation during polypeptide synthesis at the ribosome.

[ "ISBN:0198506732" ]

null

[]

[ "GO:0008182", "GO:0008183" ]

[]

[ "Reactome:R-HSA-192704 \"Synthesis of PB1-F2\"", "Reactome:R-HSA-192841 \"Viral Protein Synthesis\"" ]

[ "GO:0180051" ]

[ "part_of GO:0006414" ]

[ "part_of" ]

[ "GO:0006414" ]

[ "GO:0006414", "GO:0180051" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29089\" xsd:anyURI" ]

null

false

true

3

GO:0003747

3,747

translation release factor activity

molecular_function

Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.

[ "ISBN:0198547684" ]

null

[]

[ "GO:0003748", "GO:0003749" ]

[]

[ "GO:0008079" ]

[]

[ "GO:0008079" ]

[]

null

false

true

2

GO:0003754

3,754

obsolete chaperone activity

molecular_function

OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.

[ "ISBN:0198547684" ]

This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.

[ "chaperone activity" ]

[ "EXACT" ]

[ "GO:0003757", "GO:0003758", "GO:0003760", "GO:0003761" ]

[]

[ "GO:0006457", "GO:0044183", "GO:0051082" ]

[]

null

true

6

GO:0003755

3,755

peptidyl-prolyl cis-trans isomerase activity

molecular_function

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

[ "EC:5.2.1.8" ]

null

[ "cis-trans proline isomerase activity", "cyclophilin activity", "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity", "FK506-sensitive peptidyl-prolyl cis-trans isomerase", "immunophilin", "juglone-sensitive cis-trans proline isomerase activity", "juglone-sensitive peptidyl-prolyl cis-trans i...

[ "EXACT", "RELATED", "NARROW", "NARROW", "RELATED", "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[ "GO:0004752", "GO:0042028" ]

[]

[ "EC:5.2.1.8", "MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN", "Reactome:R-HSA-2022073 \"Procollagen triple helix formation\"", "Reactome:R-HSA-9626816 \"PIN1 binds p-S345-NCF1\"", "RHEA:16237" ]

[ "GO:0016859", "GO:0140096" ]

[]

[ "GO:0016859", "GO:0140096" ]

[]

[ "skos:exactMatch EC:5.2.1.8", "skos:exactMatch RHEA:16237", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

9

GO:0003756

3,756

protein disulfide isomerase activity

molecular_function

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.

[ "EC:5.3.4.1", "GOC:vw", "Wikipedia:Protein_disulfide-isomerase#Function" ]

null

[ "disulphide bond formation", "protein cysteine-thiol oxidation", "protein disulfide-isomerase", "protein disulphide isomerase activity", "protein thiol-disulfide exchange", "protein thiol-disulphide exchange", "S-S rearrangase activity" ]

[ "EXACT", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]

[ "GO:0006467" ]

[]

[ "EC:5.3.4.1", "MetaCyc:5.3.4.1-RXN", "Reactome:R-HSA-8950113 \"IL12A binds IL12B\"", "Reactome:R-HSA-8950183 \"IL12B binds IL23A\"", "Reactome:R-HSA-8950456 \"IL12B dimerizes\"", "Reactome:R-HSA-9760559 \"DsbA catalyzes disulfide crosslink formation on STa\"" ]

[ "GO:0016864", "GO:0140096" ]

[]

[ "GO:0016864", "GO:0140096" ]

[]

[ "skos:exactMatch EC:5.3.4.1", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0003759

3,759

obsolete glycoprotein-specific chaperone activity

molecular_function

OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins.

[ "GOC:jl", "PMID:11337494" ]

This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.

[ "glycoprotein-specific chaperone activity" ]

[ "EXACT" ]

[]

[ "GO:0006457", "GO:0044183", "GO:0051082" ]

[]

null

true

4

GO:0003762

3,762

obsolete histone-specific chaperone activity

molecular_function

OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function.

[ "GOC:jl", "PMID:7600578", "PMID:9325046" ]

This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.

[ "histone-specific chaperone activity", "nucleosome assembly chaperone" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006334", "GO:0042393" ]

[]

null

true

5

GO:0003763

3,763

obsolete chaperonin ATPase activity

molecular_function

OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.

[ "EC:3.6.4.9", "ISBN:0198547684" ]

This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.

[ "chaperonin", "chaperonin ATPase activity" ]

[ "EXACT", "EXACT" ]

[ "GO:0003764", "GO:0003765", "GO:0003766" ]

[]

[ "GO:0044183" ]

[]

null

true

8

GO:0003772

3,772

obsolete co-chaperonin activity

molecular_function

OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity.

[ "GOC:rb" ]

This term was made obsolete because it represents a class of gene products rather than a molecular function.

[ "co-chaperonin activity" ]

[ "EXACT" ]

[]

[ "GO:0006457", "GO:0044183", "GO:0051087" ]

[]

null

true

8

GO:0003773

3,773

obsolete heat shock protein activity

molecular_function

OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cel...

[ "ISBN:0198547684" ]

This term was made obsolete because it represents a class of gene products rather than a molecular function.

[ "heat shock protein activity" ]

[ "EXACT" ]

[]

[ "GO:0006986", "GO:0042026" ]

[]

null

true

4

GO:0003774

3,774

cytoskeletal motor activity

molecular_function

Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).

[ "GOC:mah", "GOC:vw", "PMID:11242086", "PMID:29716949" ]

null

[ "motor activity" ]

[ "BROAD" ]

[]

[ "goslim_candida", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_pir", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]

[ "Reactome:R-HSA-1861595 \"Extension of pseudopodia by myosin-X in a PI3K dependent manner\"" ]

[ "GO:0003674" ]

[]

[ "GO:0003674" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19590\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21756\" xsd:anyURI" ]

null

false

true

9

GO:0003775

3,775

obsolete axonemal motor activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it includes cellular component information.

[ "axonemal motor activity" ]

[ "EXACT" ]

[]

[ "GO:0003777", "GO:0005930" ]

[]

null

true

1

GO:0003776

3,776

obsolete muscle motor activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it includes anatomy information.

[ "muscle motor activity" ]

[ "EXACT" ]

[]

[ "GO:0000146" ]

[]

null

true

1

GO:0003777

3,777

microtubule motor activity

molecular_function

A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

[ "PMID:19686686", "PMID:32684327", "PMID:32842864" ]

Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.

[ "ATP-dependent microtubule motor activity", "axonemal motor activity", "dynein", "dynein ATPase activity", "kinesin", "kinesin motor activity", "kinetochore motor activity" ]

[ "EXACT", "NARROW", "BROAD", "NARROW", "BROAD", "NARROW", "NARROW" ]

[ "GO:1990939" ]

[]

[ "Reactome:R-HSA-177479 \"Axonal transport of NGF:Trk complexes\"", "Reactome:R-HSA-265160 \"Insulin secretory granule translocates to cell cortex\"", "Reactome:R-HSA-9610627 \"KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane\"" ]

[ "GO:0003774", "GO:0120544", "GO:0140657" ]

[]

[ "GO:0003774", "GO:0120544", "GO:0140657" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18664\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29690\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30980\" xsd:anyURI" ]

vw

2016-04-04T10:59:42Z

false

true

7

GO:0003778

3,778

obsolete dynactin motor

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:hjd" ]

This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.

[ "dynactin motor" ]

[ "EXACT" ]

[]

null

true

9

GO:0003779

3,779

actin binding

molecular_function

Binding to monomeric or multimeric forms of actin, including actin filaments.

[ "GOC:clt" ]

null

[ "membrane associated actin binding" ]

[ "NARROW" ]

[]

[ "GO:0008092" ]

[]

[ "GO:0008092" ]

[]

null

false

true

1

GO:0003780

3,780

obsolete actin cross-linking activity

molecular_function

OBSOLETE. Interacting selectively with two actin filaments to anchor them together.

[ "GOC:jid" ]

This term was made obsolete because it represents a combination of molecular functions.

[ "actin cross-linking activity" ]

[ "EXACT" ]

[]

[ "GO:0030674", "GO:0051015" ]

[]

null

true

9

GO:0003781

3,781

obsolete actin bundling activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a biological process.

[ "actin bundling activity" ]

[ "EXACT" ]

[]

[ "GO:0051017" ]

[]

null

true

7

GO:0003782

3,782

obsolete F-actin capping activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it describes a biological process.

[ "F-actin capping activity" ]

[ "EXACT" ]

[]

[ "GO:0051016" ]

[]

null

true

6

GO:0003783

3,783

obsolete barbed-end actin capping activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it describes a biological process.

[ "barbed-end actin capping activity" ]

[ "EXACT" ]

[]

[ "GO:0051016" ]

[]

null

true

6

GO:0003784

3,784

obsolete barbed-end actin capping/severing activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it describes two biological processes.

[ "barbed-end actin capping/severing activity" ]

[ "EXACT" ]

[]

[ "GO:0051014", "GO:0051016" ]

[]

null

true

3

GO:0003785

3,785

actin monomer binding

molecular_function

Binding to monomeric actin, also known as G-actin.

[ "GOC:ai" ]

null

[ "G actin binding" ]

[ "EXACT" ]

[]

[ "GO:0003779" ]

[]

[ "GO:0003779" ]

[]

null

false

true

6

GO:0003786

3,786

actin lateral binding

molecular_function

Binding to an actin filament along its length.

[ "GOC:mah" ]

null

[]

[ "GO:0051015" ]

[]

[ "GO:0051015" ]

[]

null

false

true

1

GO:0003787

3,787

obsolete actin depolymerizing activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it represents a biological process.

[ "actin depolymerizing activity" ]

[ "EXACT" ]

[]

[ "GO:0030042" ]

[]

null

true

7

GO:0003788

3,788

actin monomer sequestering activity

molecular_function

Binding to an actin monomer to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.

[ "PMID:11274401", "PMID:1447300" ]

null

[]

[ "GO:0140311" ]

[ "has_part GO:0003785" ]

[ "has_part" ]

[ "GO:0003785" ]

[ "GO:0003785", "GO:0140311" ]

[ "GO:0140313", "has_part GO:0003785" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29782\" xsd:anyURI" ]

null

false

true

9

GO:0003789

3,789

actin filament severing activity

molecular_function

Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments.

[ "PMID:11812157", "PMID:23395798", "PMID:23727096" ]

null

[ "actin depolymerizing activity" ]

[ "EXACT" ]

[]

[ "GO:0140776" ]

[ "has_part GO:0051015", "part_of GO:0030036" ]

[ "has_part", "part_of" ]

[ "GO:0051015", "GO:0030036" ]

[ "GO:0030036", "GO:0051015", "GO:0140776" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18437\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23065\" xsd:anyURI" ]

null

false

true

1

GO:0003790

3,790

obsolete actin modulating activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it does not make sense.

[ "actin modulating activity" ]

[ "EXACT" ]

[]

[ "GO:0030036" ]

[]

null

true

2

GO:0003791

3,791

obsolete membrane associated actin binding

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it contains both component and function information.

[ "membrane associated actin binding" ]

[ "EXACT" ]

[]

[ "GO:0003779", "GO:0016020" ]

[]

null

true

4

GO:0003792

3,792

obsolete regulation of actin thin filament length activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because the term belongs in the process ontology.

[ "regulation of actin thin filament length activity" ]

[ "EXACT" ]

[]

[ "GO:0030832" ]

[]

null

true

3

GO:0003793

3,793

obsolete defense/immunity protein activity

molecular_function

OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.

[ "GOC:curators" ]

This term was made obsolete because it refers to involvement in a biological process.

[ "defence/immunity protein activity", "defense/immunity protein activity" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006952" ]

[]

null

true

8

GO:0003794

3,794

obsolete acute-phase response protein activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it refers to involvement in a biological process.

[ "acute-phase response protein activity" ]

[ "EXACT" ]

[]

[ "GO:0006953" ]

[]

null

true

9

GO:0003795

3,795

obsolete antimicrobial peptide activity

molecular_function

OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.

[ "GOC:curators" ]

This term was made obsolete because it describes involvement in a process and not a function.

[ "antimicrobial peptide activity" ]

[ "EXACT" ]

[]

[ "GO:0019730" ]

[]

null

true

7

GO:0003796

3,796

lysozyme activity

molecular_function

Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.

[ "EC:3.2.1.17", "PMID:22748813" ]

null

[ "1,4-N-acetylmuramidase activity", "globulin G", "globulin G1", "L-7001", "lysozyme g", "mucopeptide glucohydrolase activity", "mucopeptide N-acetylmuramoylhydrolase activity", "muramidase activity", "N,O-diacetylmuramidase activity", "peptidoglycan N-acetylmuramoylhydrolase activity", "PR1-lyso...

[ "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "RELATED" ]

[]

[ "EC:3.2.1.17", "MetaCyc:3.2.1.17-RXN", "Reactome:R-HSA-8862320 \"LYZ hydrolyzes peptidoglycans in the bacterial cell wall\"" ]

[ "GO:0004553", "GO:0061783" ]

[]

[ "GO:0004553", "GO:0061783" ]

[]

[ "skos:exactMatch EC:3.2.1.17", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0003798

3,798

obsolete male-specific antibacterial peptide activity

molecular_function

OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.

[ "GOC:curators" ]

This term was made obsolete because it describes involvement in a process and not a function.

[ "male-specific antibacterial peptide activity" ]

[ "EXACT" ]

[]

[ "GO:0050831" ]

[]

null

true

3

GO:0003799

3,799

obsolete antifungal peptide activity

molecular_function

OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.

[ "GOC:curators" ]

This term was made obsolete because it describes involvement in a process and not a function.

[ "antifungal peptide activity" ]

[ "EXACT" ]

[]

[ "GO:0050832" ]

[]

null

true

4

GO:0003801

3,801

obsolete blood coagulation factor activity

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:ai" ]

This term was made obsolete because it refers to involvement in a biological process.

[ "blood coagulation factor activity" ]

[ "EXACT" ]

[]

[ "GO:0004252", "GO:0007596" ]

[]

null

true

2

GO:0003802

3,802

obsolete coagulation factor VIIa activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.

[ "PMID:12496253" ]

This term was made obsolete because it represents a gene product.

[ "activated blood coagulation factor VII", "blood coagulation factor VII activity", "blood-coagulation factor VIIa", "coagulation factor VIIa activity" ]

[ "RELATED", "EXACT", "RELATED", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0003803

3,803

obsolete coagulation factor IXa activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated blood coagulation factor XI", "activated blood-coagulation factor IX", "activated christmas factor", "autoprothrombin II", "blood coagulation factor IX activity", "blood platelet cofactor II", "blood-coagulation factor IXa", "Christmas factor activity", "coagulation factor IXa activity" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "EXACT" ]

[]

[ "GO:0004252" ]

[]

null

true

5

GO:0003804

3,804

obsolete coagulation factor Xa activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).

[ "GOC:jl", "PMID:7354023" ]

This term was made obsolete because it represents a gene product.

[ "activated blood-coagulation factor X", "activated factor X", "activated Stuart-Prower factor", "autoprothrombin C", "blood coagulation factor X activity", "coagulation factor Xa activity", "factor Xa", "plasma thromboplastin", "prothrombase activity", "prothrombinase activity", "Stuart factor",...

[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

1

GO:0003805

3,805

obsolete coagulation factor XIa activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated blood-coagulation factor XI", "activated plasma thromboplastin antecedent", "blood coagulation factor XI activity", "blood-coagulation factor XIa", "coagulation factor XIa activity", "plasma thromboplastin antecedent activity" ]

[ "RELATED", "RELATED", "EXACT", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0003806

3,806

obsolete coagulation factor XIIa activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated beta blood-coagulation factor XII", "blood coagulation factor XII activity", "blood-coagulation factor XIIabeta", "blood-coagulation factor XIIf", "coagulation factor XIIa activity", "hageman factor (activated)", "hageman factor activity", "hageman factor beta-fragment", "hageman factor f...

[ "RELATED", "EXACT", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0003807

3,807

obsolete plasma kallikrein activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "callicrein", "depot-padutin", "dilminal D", "glumorin", "kallidinogenase", "kallikrein", "kallikrein I", "kallikrein II", "kininogenase", "kininogenin activity", "onokrein P", "padreatin", "padutin", "panceatic kallikrein", "plasma kallikrein activity", "serum kallikrein activity", ...

[ "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0003808

3,808

obsolete protein C (activated) activity

molecular_function

OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated blood coagulation factor XIV activity", "activated protein C", "autoprothrombin II-A", "autoprothrombin IIA activity", "blood-coagulation factor XIVa", "GSAPC", "protein C (activated) activity", "protein Ca" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

5

GO:0003809

3,809

obsolete thrombin activity

molecular_function

OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated blood-coagulation factor II", "beta-thrombin", "blood-coagulation factor IIa", "E thrombin", "factor IIa", "fibrinogenase activity", "gamma-thrombin", "thrombase activity", "thrombin activity", "thrombin-C", "thrombofort", "topical", "tropostasin" ]

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0003810

3,810

protein-glutamine gamma-glutamyltransferase activity

molecular_function

Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as ac...

[ "EC:2.3.2.13" ]

null

[ "factor XIIIa", "fibrin stabilizing factor", "fibrinoligase activity", "glutaminylpeptide gamma-glutamyltransferase activity", "polyamine transglutaminase activity", "protein-glutamine:amine gamma-glutamyltransferase", "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity", "TGase activity",...

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "NARROW", "EXACT" ]

[]

[ "EC:2.3.2.13", "MetaCyc:2.3.2.13-RXN", "Reactome:R-HSA-140851 \"fibrin multimer -> fibrin multimer, crosslinked + NH4+\"", "Reactome:R-HSA-6810894 \"Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking\"", "RHEA:54816" ]

[ "GO:0016755", "GO:0140096" ]

[]

[ "GO:0016755", "GO:0140096" ]

[]

[ "skos:exactMatch EC:2.3.2.13", "skos:exactMatch RHEA:54816", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

4

GO:0003811

3,811

obsolete complement activity

molecular_function

OBSOLETE. Any of a set of activities involved in the complement cascade.

[ "GOC:jl" ]

This term was made obsolete because it refers to involvement in a biological process.

[ "complement activity" ]

[ "EXACT" ]

[]

[ "GO:0006956" ]

[]

null

true

3

GO:0003812

3,812

obsolete alternative-complement-pathway C3/C5 convertase activity

molecular_function

OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "(C3b)n,Bb", "(CVF)-dependent glycine-rich-beta-glucoprotein", "alternative complement pathway C3(C5) convertase activity", "alternative-complement-pathway C3/C5 convertase activity", "C3 convertase activity", "C3 proactivator", "C3b,Bb,CVF,Bb,C5 convertase activity", "C5 convertase activity", "cobr...

[ "RELATED", "RELATED", "RELATED", "EXACT", "BROAD", "RELATED", "RELATED", "BROAD", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

6

GO:0003813

3,813

obsolete classical-complement-pathway C3/C5 convertase activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "C3 convertase activity", "C42", "C423", "C4b,2a", "C4b,2a,3b", "C5 convertase activity", "classical-complement-pathway C3/C5 convertase activity", "complement C2 activity", "complement C3 convertase activity", "complement C42" ]

[ "BROAD", "RELATED", "RELATED", "RELATED", "RELATED", "BROAD", "EXACT", "BROAD", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

2

GO:0003815

3,815

obsolete complement component C1r activity

molecular_function

OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "activated complement C1r", "C1r esterase activity", "complement component C1r activity", "complement subcomponent C1r" ]

[ "RELATED", "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

3

GO:0003817

3,817

obsolete complement factor D activity

molecular_function

OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "adipsin", "C3 convertase activator activity", "C3 proactivator convertase activity", "complement factor D activity", "factor D", "factor D (complement)", "properdin factor D esterase activity" ]

[ "EXACT", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

4

GO:0003818

3,818

obsolete complement factor I activity

molecular_function

OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.

[ "GOC:curators" ]

This term was made obsolete because it represents a gene product.

[ "C3b inactivator activity", "C3b/C4b inactivator activity", "C3bINA", "complement C3b inactivator", "complement C3b/C4b inactivator", "complement C4b inactivator", "complement C4bi", "complement component C3b inactivator activity", "complement factor I activity", "conglutinogen-activating factor C...

[ "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "RELATED" ]

[]

[ "GO:0004252" ]

[]

null

true

7

GO:0003819

3,819

obsolete major histocompatibility complex antigen

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.

[ "major histocompatibility complex antigen", "MHC protein" ]

[ "EXACT", "EXACT" ]

[]

null

true

9

GO:0003820

3,820

obsolete class I major histocompatibility complex antigen

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.

[ "class I major histocompatibility complex antigen" ]

[ "EXACT" ]

[]

[ "GO:0042612" ]

[]

null

true

4

GO:0003821

3,821

obsolete class II major histocompatibility complex antigen

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.

[ "class II major histocompatibility complex antigen" ]

[ "EXACT" ]

[]

[ "GO:0042613" ]

[]

null

true

7

GO:0003822

3,822

obsolete MHC-interacting protein

molecular_function

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a gene product.

[ "MHC-interacting protein" ]

[ "EXACT" ]

[]

null

true

7

GO:0003823

3,823

antigen binding

molecular_function

Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein compl...

[ "GOC:jl", "ISBN:0198506732", "ISBN:0721662544" ]

null

[ "antibody activity", "B cell receptor activity", "major histocompatibility complex activity", "major histocompatibility complex antigen display activity", "MHC activity", "opsonin activity" ]

[ "RELATED", "NARROW", "NARROW", "NARROW", "NARROW", "NARROW" ]

[]

[ "goslim_chembl", "goslim_pir" ]

[]

[ "GO:0005488" ]

[]

[ "GO:0005488" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25644\" xsd:anyURI" ]

null

false

true

1

GO:0003824

3,824

catalytic activity

molecular_function

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or l...

[ "GOC:vw", "ISBN:0198506732" ]

null

[ "enzyme activity" ]

[ "EXACT" ]

[]

[ "goslim_agr", "goslim_chembl", "goslim_euk_cellular_processes_ribbon", "goslim_flybase_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote_ribbon" ]

[ "Wikipedia:Enzyme" ]

[ "GO:0003674" ]

[]

[ "GO:0003674" ]

[]

null

false

true

9

GO:0003825

3,825

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

molecular_function

Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.

[ "EC:2.4.1.15" ]

null

[ "alpha,alpha-trehalose phosphate synthase (UDP-forming)", "phosphotrehalose-uridine diphosphate transglucosylase activity", "transglucosylase activity", "trehalose 6-phosphate synthase activity", "trehalose 6-phosphate synthetase activity", "trehalose phosphate synthase activity", "trehalose phosphate s...

[ "RELATED", "RELATED", "EXACT", "EXACT", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.15", "MetaCyc:TREHALOSE6PSYN-RXN", "RHEA:18889" ]

[ "GO:0035251" ]

[]

[ "GO:0035251" ]

[]

[ "skos:exactMatch EC:2.4.1.15", "skos:exactMatch RHEA:18889", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

7

GO:0003827

3,827

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

molecular_function

Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP.

[ "EC:2.4.1.101", "RHEA:11456" ]

null

[ "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity", "GnTI", "GNTI activity", "N-acetylglucosaminyltransfer...

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.101", "KEGG_REACTION:R05983", "MetaCyc:2.4.1.101-RXN", "Reactome:R-HSA-964768 \"Addition of GlcNAc to the glycan on the A arm\"", "RHEA:11456" ]

[ "GO:0008375", "GO:0140103" ]

[]

[ "GO:0008375", "GO:0140103" ]

[]

[ "skos:exactMatch EC:2.4.1.101", "skos:exactMatch RHEA:11456", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

1

GO:0003828

3,828

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

molecular_function

Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.

[ "EC:2.4.3.8" ]

null

[ "alpha-2,8-sialyltransferase activity", "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity", "cytidine monophosphoacetylneuraminate-ganglioside GM3", "ganglioside GD3 synthase activity", "ganglioside GD3 synthetase sialyltransferase activity" ]

[ "RELATED", "EXACT", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.3.8", "MetaCyc:2.4.99.8-RXN", "Reactome:R-HSA-1022133 \"ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-4084978 \"ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues\"", "Reactome:R-HSA-422454 \"Polysialylation of NCAM1\"", "Reactome:R-HSA-9845587 \"ST8SIA5 transfers...

[ "GO:0008373" ]

[]

[ "GO:0008373" ]

[]

[ "skos:exactMatch EC:2.4.3.8", "skos:exactMatch RHEA:19313", "skos:narrowMatch RHEA:48288", "skos:narrowMatch RHEA:48912", "skos:narrowMatch RHEA:48924", "skos:narrowMatch RHEA:48932", "skos:narrowMatch RHEA:77387", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:any...

null

false

true

2

GO:0003829

3,829

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

molecular_function

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. This reaction is the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core...

[ "EC:2.4.1.102" ]

null

[ "beta(6)-N-acetylglucosaminyltransferase activity", "beta6-N-acetylglucosaminyltransferase activity", "core 2 acetylglucosaminyltransferase activity", "core 6-beta-GlcNAc-transferase A", "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity", "UDP-N-acetyl-D-glucosamine:O-gly...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.102", "MetaCyc:2.4.1.102-RXN", "Reactome:R-HSA-914012 \"GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins\"", "Reactome:R-HSA-914018 \"GCNT3 transfers GlcNAc to Core 3 mucin\"", "RHEA:18705", "RHEA:56212", "RHEA:56216" ]

[ "GO:0008375", "GO:0140103" ]

[]

[ "GO:0008375", "GO:0140103" ]

[]

[ "skos:exactMatch EC:2.4.1.102", "skos:exactMatch RHEA:18705", "skos:narrowMatch RHEA:56212", "skos:narrowMatch RHEA:56216", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21793\" xsd:anyURI" ]

null

false

true

1

GO:0003830

3,830

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

molecular_function

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.

[ "EC:2.4.1.144" ]

null

[ "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity", "GnTIII activity", "N-acetylglucosaminyltransferase III activity", "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.144", "MetaCyc:2.4.1.144-RXN", "Reactome:R-HSA-975926 \"Addition of a bifurcating GlcNAc to the N-glycan by MGAT3\"", "RHEA:15509" ]

[ "GO:0008375", "GO:0140103" ]

[]

[ "GO:0008375", "GO:0140103" ]

[]

[ "skos:exactMatch EC:2.4.1.144", "skos:exactMatch RHEA:15509", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

6

GO:0003831

3,831

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

molecular_function

Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.

[ "EC:2.4.1.38" ]

null

[ "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity", "beta-N-acetyl-beta-1,4-galactosyltransferase activity", "GalT activity", "glycoprotein 4-beta-galactosyl-transferase activity", "glycoprotein 4-beta-galactosyltransferase activity", "glycoprotein beta-galactosyltransferase activity", "thyroid g...

[ "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:2.4.1.38", "MetaCyc:2.4.1.38-RXN", "Reactome:R-HSA-1912352 \"Galactosylation of Pre-NOTCH\"", "Reactome:R-HSA-2025723 \"B4GALTs transfer Gal to the N-glycan precursor\"", "Reactome:R-HSA-2046265 \"B4GALTs transfer Gal to the keratan chain\"", "Reactome:R-HSA-2046298 \"B4GALTs transfer Gal to a branch ...

[ "GO:0035250" ]

[]

[ "GO:0035250" ]

[]

[ "skos:exactMatch EC:2.4.1.38", "skos:exactMatch RHEA:22932", "skos:narrowMatch RHEA:56260", "skos:narrowMatch RHEA:82127", "skos:narrowMatch RHEA:82967", "skos:narrowMatch RHEA:84999", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

2

GO:0003834

3,834

beta-carotene 15,15'-dioxygenase activity

molecular_function

Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal.

[ "RHEA:32887" ]

null

[ "beta-carotene 15,15'-monooxygenase activity", "carotene 15,15'-dioxygenase activity", "carotene dioxygenase activity" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "EC:1.13.11.63", "KEGG_REACTION:R00032", "MetaCyc:RXN-13374", "Reactome:R-HSA-975635 \"BCMO1:Fe2+ cleaves betaC to atRAL\"", "RHEA:32887" ]

[ "GO:0016702" ]

[]

[ "GO:0016702" ]

[]

[ "skos:exactMatch EC:1.13.11.63", "skos:exactMatch RHEA:32887", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21765\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0003835

3,835

beta-galactoside alpha-2,6-sialyltransferase activity

molecular_function

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+.

[ "EC:2.4.3.1" ]

null

[ "beta-galactosamide alpha-2,6-sialyltransferase activity", "beta-galactoside alpha-(2,6)-sialyltransferase", "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity", "lactosylceramide alpha-2,6-N-sialyltransferase" ]

[ "EXACT", "EXACT", "RELATED", "RELATED" ]

[]

[ "EC:2.4.3.1", "MetaCyc:RXN-18268", "Reactome:R-HSA-4085033 \"ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)\"", "Reactome:R-HSA-975902 \"ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-977071 \"ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens\"", "RHE...

[ "GO:0008373" ]

[]

[ "GO:0008373" ]

[]

[ "skos:exactMatch EC:2.4.3.1", "skos:exactMatch RHEA:52104", "skos:narrowMatch RHEA:11836", "skos:narrowMatch RHEA:21552", "skos:narrowMatch RHEA:56268", "skos:narrowMatch RHEA:82903", "skos:narrowMatch RHEA:82947", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:any...

null

false

true

5

GO:0003836

3,836

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

molecular_function

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.

[ "EC:2.4.3.4" ]

null

[]

[ "EC:2.4.3.4", "MetaCyc:2.4.99.4-RXN", "Reactome:R-HSA-1022129 \"ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans\"", "Reactome:R-HSA-1912378 \"Sialylation of Pre-NOTCH\"", "Reactome:R-HSA-2046285 \"ST3GAL1-4,6 optionally cap keratan chain\"", "Reactome:R-HSA-3656258 \"Defective ST3GAL3 does not trans...

[ "GO:0008373" ]

[]

[ "GO:0008373" ]

[]

[ "skos:exactMatch EC:2.4.3.4", "skos:exactMatch RHEA:21616", "skos:narrowMatch RHEA:56204", "skos:narrowMatch RHEA:56208", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0003837

3,837

beta-ureidopropionase activity

molecular_function

Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH4+.

[ "EC:3.5.1.6" ]

null

[ "N-carbamoyl-beta-alanine amidohydrolase activity" ]

[ "RELATED" ]

[]

[ "EC:3.5.1.6", "MetaCyc:BETA-UREIDOPROPIONASE-RXN", "Reactome:R-HSA-73591 \"beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2\"", "Reactome:R-HSA-73620 \"beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2\"", "RHEA:11184" ]

[ "GO:0016811" ]

[]

[ "GO:0016811" ]

[]

[ "skos:exactMatch EC:3.5.1.6", "skos:exactMatch RHEA:11184", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI" ]

null

false

true

3

GO:0003838

3,838

sterol 24-C-methyltransferase activity

molecular_function

Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine.

[ "RHEA:21128" ]

null

[ "24-sterol C-methyltransferase activity", "delta(24)-methyltransferase activity", "delta(24)-sterol C-methyltransferase activity", "delta(24)-sterol methyltransferase activity", "delta24-methyltransferase activity", "delta24-sterol methyltransferase activity", "phytosterol methyltransferase activity", ...

[ "RELATED", "RELATED", "EXACT", "RELATED", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED", "NARROW", "EXACT", "NARROW" ]

[ "GO:0102101" ]

[]

[ "EC:2.1.1.41", "MetaCyc:RXN3O-178", "RHEA:21128" ]

[ "GO:0008169", "GO:0008757" ]

[]

[ "GO:0008169", "GO:0008757" ]

[]

[ "skos:exactMatch EC:2.1.1.41", "skos:exactMatch RHEA:21128", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20399\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25963\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontol...

null

false

true

3