go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0003839 | 3,839 | gamma-glutamylcyclotransferase activity | molecular_function | Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. | [
"PMID:18515354"
] | null | [
"(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)",
"gamma-glutamyl-amino acid cyclotransferase activity",
"gamma-L-glutamylcyclotransferase activity",
"L-glutamic cyclase activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:4.3.2.9",
"MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN",
"Reactome:R-HSA-1247922 \"GGCT transforms gGluCys to OPRO\"",
"RHEA:20505"
] | [
"GO:0016842"
] | [] | [] | [] | [
"GO:0016842"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.3.2.9",
"skos:exactMatch RHEA:20505",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003840 | 3,840 | obsolete gamma-glutamyltransferase activity | molecular_function | OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. | [
"GOC:curators"
] | This term was obsoleted because it does not correspond to a physiological reaction.\nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the... | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0036374"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/13571\" xsd:anyURI"
] | null | null | true | true | 2 |
GO:0003841 | 3,841 | 1-acylglycerol-3-phosphate O-acyltransferase activity | molecular_function | Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. | [
"EC:2.3.1.51",
"GOC:ab"
] | null | [
"1-acyl-sn-glycero-3-phosphate acyltransferase activity",
"1-acyl-sn-glycerol 3-phosphate acyltransferase activity",
"1-acyl-sn-glycerol-3-phosphate acyltransferase activity",
"1-acylglycero-3-phosphate acyltransferase activity",
"1-acylglycerolphosphate acyltransferase activity",
"1-acylglycerophosphate ... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [
"GO:0004469"
] | [] | [
"EC:2.3.1.51",
"MetaCyc:RXN-1623",
"Reactome:R-HSA-1482539 \"1-acyl LPG is acylated to PG by LPGAT\"",
"Reactome:R-HSA-1482547 \"1-acyl LPC is acylated to PC by LPCAT\"",
"Reactome:R-HSA-1482548 \"1-acyl LPA is acylated to PA by AGPAT5 (OM)\"",
"Reactome:R-HSA-1482598 \"1-acyl LPI is acylated to PI by MBO... | [
"GO:0016411",
"GO:0042171"
] | [] | [] | [] | [
"GO:0016411",
"GO:0042171"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.51",
"skos:exactMatch RHEA:19709",
"skos:narrowMatch RHEA:33187",
"skos:narrowMatch RHEA:33315",
"skos:narrowMatch RHEA:33319",
"skos:narrowMatch RHEA:35911",
"skos:narrowMatch RHEA:35915",
"skos:narrowMatch RHEA:37135",
"skos:narrowMatch RHEA:37139",
"skos:narrowMatch RH... | null | null | false | true | 7 |
GO:0003842 | 3,842 | L-glutamate gamma-semialdehyde dehydrogenase activity | molecular_function | L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + 2 H+. | [
"RHEA:30235"
] | (S)-1-pyrroline-5-carboxylate is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. The activity can also oxidize other 1-pyrrolines, e.g. oxidation of 3-hydroxy-1-pyrroline-5-carboxylate to 4-hydroxyglutamate, and oxidation of (R)-1-pyrroline-5-carboxylate to D-glutamate. | [
"1-pyrroline dehydrogenase",
"1-pyrroline-5-carboxylate dehydrogenase activity",
"1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity",
"delta1-pyrroline-5-carboxylate dehydrogenase activity",
"L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity",
"pyrroline-5-carboxylate dehydrogenase activity",
... | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.1.88",
"MetaCyc:RXN-14116",
"Reactome:R-HSA-6784402 \"ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate\"",
"Reactome:R-HSA-70679 \"ALDH4A1 oxidises L-GluSS to Glu\"",
"Reactome:R-HSA-9929439 \"ALDH4A1 oxidizes 1PYR-3OH-5COOH\"",
"RHEA:30235"
] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.88",
"skos:exactMatch RHEA:30235",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23277\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30034\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003843 | 3,843 | 1,3-beta-D-glucan synthase activity | molecular_function | Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1). | [
"EC:2.4.1.34"
] | null | [
"(1,3)-beta-glucan (callose) synthase activity",
"1,3-beta-D-glucan synthetase activity",
"1,3-beta-D-glucan-UDP glucosyltransferase activity",
"1,3-beta-glucan synthase activity",
"1,3-beta-glucan-uridine diphosphoglucosyltransferase activity",
"beta-1,3-glucan synthase activity",
"beta-1,3-glucan synt... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0009981"
] | [] | [
"EC:2.4.1.34",
"MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN",
"RHEA:21476"
] | [
"GO:0035251"
] | [] | [] | [] | [
"GO:0035251"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.34",
"skos:exactMatch RHEA:21476",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003844 | 3,844 | 1,4-alpha-glucan branching enzyme activity | molecular_function | Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. | [
"EC:2.4.1.18"
] | null | [
"1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity",
"1,4-glucan-6-(1,4-glucano)-transferase activity",
"alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity",
"alpha-glucan-branching glycosyltransferase activity",
"amylo-(1,4 to 1,6)transglucosidase acti... | [
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.1.18",
"MetaCyc:GLYCOGEN-BRANCH-RXN",
"MetaCyc:RXN-7669",
"Reactome:R-HSA-3322005 \"GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a\"",
"Reactome:R-HSA-3322016 \"GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a\"",
"Reactome:R-HSA-3322057 \"GBE1 catalyzes... | [
"GO:0016758"
] | [] | [] | [] | [
"GO:0016758"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.18",
"skos:exactMatch MetaCyc:GLYCOGEN-BRANCH-RXN",
"skos:narrowMatch MetaCyc:RXN-7669",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28286\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003845 | 3,845 | obsolete 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity | molecular_function | OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+. | [
"PMID:15761036"
] | This term was obsoleted because it is an unnecessary grouping term. | [
"11beta-hydroxy steroid dehydrogenase",
"11beta-hydroxysteroid dehydrogenase",
"beta-hydroxysteroid dehydrogenase",
"corticosteroid 11-reductase",
"corticosteroid 11beta-dehydrogenase"
] | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"Wikipedia:11beta-hydroxysteroid_dehydrogenase"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0070523",
"GO:0070524"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21915\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28173\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28298\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0003846 | 3,846 | 2-acylglycerol O-acyltransferase activity | molecular_function | Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. | [
"PMID:4016575",
"RHEA:16741"
] | null | [
"acyl coenzyme A-monoglyceride acyltransferase activity",
"acyl-CoA:2-acylglycerol O-acyltransferase activity",
"acylglycerol palmitoyltransferase activity",
"monoacylglycerol acyltransferase activity",
"monoglyceride acyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.22",
"MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN",
"Reactome:R-HSA-5696448 \"AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG\"",
"Reactome:R-HSA-6800334 \"MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG\"",
"RHEA:16741",
"RHEA:32947",
"RHEA:38467",
"... | [
"GO:0016411"
] | [] | [] | [] | [
"GO:0016411"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.22",
"skos:exactMatch RHEA:16741",
"skos:narrowMatch RHEA:32947",
"skos:narrowMatch RHEA:38467",
"skos:narrowMatch RHEA:39951",
"skos:narrowMatch RHEA:77271",
"skos:narrowMatch RHEA:77275",
"skos:narrowMatch RHEA:77279",
"skos:narrowMatch RHEA:77283",
"skos:narrowMatch RH... | null | null | false | true | 3 |
GO:0003847 | 3,847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity | molecular_function | Catalysis of the reaction: a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H+. | [
"RHEA:17777"
] | null | [
"1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity",
"1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity",
"2-acetyl-1-alkylglycerophosphocholine esterase activity",
"alkylacetyl-GPC:acetylhydrolase activity",
"LDL-associated phospholipase A(2) activity",
"LDL-associa... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.47",
"MetaCyc:3.1.1.47-RXN",
"Reactome:R-HSA-8869206 \"PAFAH2 hydrolyses PAF to lyso-PAF and acetate\"",
"RHEA:17777",
"RHEA:40479",
"RHEA:41183",
"RHEA:41368",
"RHEA:41372",
"RHEA:41376"
] | [
"GO:0052689"
] | [] | [] | [] | [
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.47",
"skos:exactMatch RHEA:17777",
"skos:narrowMatch RHEA:40479",
"skos:narrowMatch RHEA:41183",
"skos:narrowMatch RHEA:41368",
"skos:narrowMatch RHEA:41372",
"skos:narrowMatch RHEA:41376",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:an... | null | null | false | true | 6 |
GO:0003848 | 3,848 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | molecular_function | Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. | [
"EC:2.7.6.3",
"RHEA:11412"
] | null | [
"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity",
"6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity",
"6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity",
"7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity",
"7,8-dihydro-6-hydroxymethylpterin pyrop... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:2.7.6.3",
"KEGG_REACTION:R03503",
"MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN",
"RHEA:11412"
] | [
"GO:0016778"
] | [] | [] | [] | [
"GO:0016778"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.6.3",
"skos:exactMatch RHEA:11412",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003849 | 3,849 | 3-deoxy-7-phosphoheptulonate synthase activity | molecular_function | Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. | [
"EC:2.5.1.54",
"RHEA:14717"
] | null | [
"2-dehydro-3-deoxy-phosphoheptonate aldolase activity",
"2-dehydro-3-deoxyphosphoheptonate aldolase activity",
"2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity",
"3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity",
"3-deoxy-D-arabino-heptolosonate-7-phosphate synth... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELAT... | [] | [] | [
"EC:2.5.1.54",
"KEGG_REACTION:R01826",
"MetaCyc:DAHPSYN-RXN",
"RHEA:14717"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.54",
"skos:exactMatch RHEA:14717",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003850 | 3,850 | 2-deoxyglucose-6-phosphatase activity | molecular_function | Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. | [
"EC:3.1.3.68"
] | null | [
"2-deoxy-D-glucose-6-phosphate phosphohydrolase activity",
"2-deoxyglucose-6-phosphate phosphatase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.3.68",
"KEGG_REACTION:R02587",
"MetaCyc:3.1.3.68-RXN",
"RHEA:22236"
] | [
"GO:0050308"
] | [] | [] | [] | [
"GO:0050308"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.3.68",
"skos:exactMatch RHEA:22236",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003851 | 3,851 | N-acylsphingosine galactosyltransferase activity | molecular_function | Catalysis of the reaction: N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H+ + UDP. | [
"EC:2.4.1.47"
] | null | [
"2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity"
] | [
"EXACT"
] | [] | [] | [
"EC:2.4.1.47",
"MetaCyc:2.4.1.47-RXN",
"Reactome:R-HSA-6785933 \"UGT8 transfers Gal from UDP-Gal to CERA\"",
"RHEA:10856",
"RHEA:13093",
"RHEA:44896"
] | [
"GO:0035250"
] | [] | [] | [] | [
"GO:0035250"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.47",
"skos:exactMatch RHEA:13093",
"skos:narrowMatch RHEA:10856",
"skos:narrowMatch RHEA:44896",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27410\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27679\" xsd:anyURI... | null | null | false | true | 8 |
GO:0003852 | 3,852 | 2-isopropylmalate synthase activity | molecular_function | Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. | [
"RHEA:21524"
] | null | [
"3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity",
"acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)",
"alpha-IPM synthetase activity",
"alpha-isopropylmalate synthase activity",
"alpha-isopropylmalate synth... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.3.13",
"KEGG_REACTION:R01213",
"MetaCyc:2-ISOPROPYLMALATESYN-RXN",
"RHEA:21524"
] | [
"GO:0046912"
] | [] | [] | [] | [
"GO:0046912"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.3.13",
"skos:exactMatch RHEA:21524",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003853 | 3,853 | short-chain 2-methyl fatty acyl-CoA dehydrogenase activity | molecular_function | Catalysis of the reaction: Catalysis of the reaction: a short-chain 2-methyl fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-2-methyl-2-enoyl-CoA + reduced [electron-transfer flavoprotein]. | [
"PMID:10989435",
"PMID:6401712"
] | null | [
"2-methyl branched chain acyl-CoA dehydrogenase activity",
"2-methyl-branched-chain-enoyl-CoA reductase activity",
"2-methylacyl-CoA dehydrogenase activity",
"2-methylbutanoyl-CoA dehydrogenase activity",
"2-methylpropanoyl-CoA dehydrogenase activity",
"branched-chain acyl-CoA dehydrogenase activity",
"... | [
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0047119"
] | [] | [
"EC:1.3.8.5",
"KEGG_REACTION:R03169",
"MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN",
"RHEA:43780",
"RHEA:44180"
] | [
"GO:0016937"
] | [] | [] | [] | [
"GO:0016937"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.8.5",
"skos:narrowMatch MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN",
"skos:narrowMatch RHEA:43780",
"skos:narrowMatch RHEA:44180",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23472\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-on... | null | null | false | true | 8 |
GO:0003854 | 3,854 | 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: a 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone. | [
"EC:1.1.1.145"
] | null | [
"3-beta-hydroxy-5-ene steroid dehydrogenase activity",
"3-beta-hydroxy-D5-steroid dehydrogenase activity",
"3beta-HSDH",
"3beta-hydroxy steroid dehydrogenase/isomerase activity",
"3beta-hydroxy-5-ene steroid dehydrogenase activity",
"3beta-hydroxy-5-ene-steroid dehydrogenase activity",
"3beta-hydroxy-5-... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.1.1.145",
"MetaCyc:1.1.1.145-RXN",
"Reactome:R-HSA-192097 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one\"",
"Reactome:R-HSA-193789 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one\"",
"Reactome:R-HSA-1938... | [
"GO:0033764"
] | [] | [] | [] | [
"GO:0033764"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.145",
"skos:narrowMatch RHEA:24076",
"skos:narrowMatch RHEA:43932",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003855 | 3,855 | 3-dehydroquinate dehydratase activity | molecular_function | Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. | [
"EC:4.2.1.10",
"RHEA:21096"
] | null | [
"3-dehydroquinase activity",
"3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)",
"3-dehydroquinate hydro-lyase activity",
"3-dehydroquinate hydrolase activity",
"5-dehydroquinase activity",
"5-dehydroquinate dehydratase activity",
"5-dehydroquinate hydro-lyase activity",
"dehydroquinase activ... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.10",
"KEGG_REACTION:R03084",
"MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN",
"RHEA:21096"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.10",
"skos:exactMatch RHEA:21096",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003856 | 3,856 | 3-dehydroquinate synthase activity | molecular_function | Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. | [
"EC:4.2.3.4",
"RHEA:21968"
] | null | [] | [] | [] | [] | [
"EC:4.2.3.4",
"KEGG_REACTION:R03083",
"MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN",
"RHEA:21968"
] | [
"GO:0016838"
] | [] | [] | [] | [
"GO:0016838"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.3.4",
"skos:exactMatch RHEA:21968",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003857 | 3,857 | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+. | [
"RHEA:22432"
] | null | [
"3-oxoacyl-thioester reductase activity",
"beta-hydroxyacyl dehydrogenase activity",
"beta-hydroxyacyl-coenzyme A synthetase activity",
"beta-hydroxyacylcoenzyme A dehydrogenase activity",
"beta-hydroxybutyrylcoenzyme A dehydrogenase activity",
"beta-keto-reductase activity",
"beta-ketoacyl-CoA reductas... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.35",
"MetaCyc:OHACYL-COA-DEHYDROG-RXN",
"Reactome:R-HSA-193455 \"(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA\"",
"Reactome:R-HSA-193508 \"(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA... | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.35",
"skos:exactMatch RHEA:22432",
"skos:narrowMatch RHEA:34851",
"skos:narrowMatch RHEA:40211",
"skos:narrowMatch RHEA:78919",
"skos:narrowMatch RHEA:78923",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30577\" xsd:anyURI",
"term_tracker_item \"htt... | null | null | false | true | 3 |
GO:0003858 | 3,858 | 3-hydroxybutyrate dehydrogenase activity | molecular_function | Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH. | [
"EC:1.1.1.30",
"RHEA:20521"
] | null | [
"D-beta-hydroxybutyrate dehydrogenase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.1.1.30",
"KEGG_REACTION:R01361",
"MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN",
"Reactome:R-HSA-5696457 \"BDH2 dehydrogenates 3HBA\"",
"Reactome:R-HSA-73912 \"acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+\"",
"Reactome:R-HSA-73920 \"D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+... | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.30",
"skos:exactMatch RHEA:20521",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003859 | 3,859 | obsolete (3R)-3-hydroxybutyryl-CoA dehydratase activity | molecular_function | OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O. | [
"EC:4.2.1.55",
"RHEA:17849"
] | This term was obsoleted because it represents a specific substrate of 3-hydroxyacyl-CoA dehydratase activity ; GO:0018812. | [
"(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)",
"(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity",
"3-hydroxybutyryl-CoA dehydratase activity",
"crotonase activity",
"D-3-hydroxybutyryl coenzyme A dehydratase activity",
"D-3-hydroxybutyryl-CoA dehydratase activity",
"enoyl coenzyme A h... | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0018812"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24738\" xsd:anyURI"
] | null | null | true | true | 8 |
GO:0003860 | 3,860 | 3-hydroxyisobutyryl-CoA hydrolase activity | molecular_function | Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. | [
"EC:3.1.2.4"
] | null | [
"3-hydroxy-2-methylpropanoyl-CoA hydrolase activity",
"3-hydroxy-isobutyryl CoA hydrolase activity",
"HIB CoA deacylase activity"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.2.4",
"MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN",
"Reactome:R-HSA-70881 \"beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA\"",
"Reactome:R-HSA-9916727 \"HIBCH mutants don't synthesize beta-hydroxyisobutyrate\"",
"RHEA:20888"
] | [
"GO:0141126"
] | [] | [] | [] | [
"GO:0141126"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.2.4",
"skos:exactMatch RHEA:20888",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26441\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003861 | 3,861 | 3-isopropylmalate dehydratase activity | molecular_function | Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. | [
"EC:4.2.1.33"
] | null | [
"(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)",
"(2R,3S)-3-isopropylmalate hydro-lyase activity",
"alpha-IPM isomerase activity",
"alpha-isopropylmalate isomerase activity",
"beta-isopropylmalate dehydratase activity",
"isopropylmalate isomerase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.1.33",
"MetaCyc:3-ISOPROPYLMALISOM-RXN",
"RHEA:32287"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.33",
"skos:exactMatch RHEA:32287",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003862 | 3,862 | 3-isopropylmalate dehydrogenase activity | molecular_function | Catalysis of the reaction: (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH. | [
"RHEA:32271"
] | null | [
"(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity",
"3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity",
"beta-IPM dehydrogenase activity",
"beta-isopropylmalate dehydrogenase activity",
"beta-isopropylmalic enzyme",
"IMDH activity",
"IPMDH",
"threo-Ds-3-isopropylmalate dehydro... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.85",
"MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN",
"RHEA:32271"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.85",
"skos:exactMatch RHEA:32271",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29562\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003863 | 3,863 | branched-chain 2-oxo acid dehydrogenase activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H+ = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2. Also acts on 4-methyl-2-oxopentanoate and (S)-3-me... | [
"EC:1.2.4.4"
] | null | [
"2-oxoisocaproate dehydrogenase activity",
"2-oxoisovalerate (lipoate) dehydrogenase activity",
"3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity",
"3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity",
"3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropa... | [
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0003826"
] | [] | [
"EC:1.2.4.4",
"MetaCyc:1.2.4.4-RXN",
"RHEA:13457",
"RHEA:84639",
"RHEA:84643"
] | [
"GO:0016624"
] | [] | [] | [] | [
"GO:0016624"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.2.1.25",
"skos:broadMatch MetaCyc:1.2.1.25-RXN",
"skos:exactMatch EC:1.2.4.4",
"skos:exactMatch MetaCyc:1.2.4.4-RXN",
"skos:narrowMatch RHEA:13457",
"skos:narrowMatch RHEA:84639",
"skos:narrowMatch RHEA:84643",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issu... | null | null | false | true | 1 |
GO:0003864 | 3,864 | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity | molecular_function | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. | [
"EC:2.1.2.11"
] | null | [
"5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity",
"5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity",
"alpha-ketoisovalerate hydroxymethyltransferase activity",
"dehydropantoate hydroxymethyltransferase activity",
"ketopantoate... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.2.11",
"MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN",
"RHEA:11824"
] | [
"GO:0016742"
] | [] | [] | [] | [
"GO:0016742"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.2.11",
"skos:exactMatch RHEA:11824",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003865 | 3,865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | molecular_function | Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. | [
"EC:1.3.99.5"
] | null | [
"3-keto-delta4-steroid-5alpha-reductase activity",
"3-oxo-5alpha-steroid 4-dehydrogenase activity",
"3-oxo-5alpha-steroid delta4-dehydrogenase activity",
"3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity",
"3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity",
"3-oxosteroid delta4-d... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:1.3.99.5",
"MetaCyc:RXN-13682",
"Reactome:R-HSA-469659 \"SRD5A1 dehydrogenates TEST to DHTEST\"",
"Reactome:R-HSA-9705713 \"SRD5A2 dehydrogenates TEST to DHTEST\"",
"Reactome:R-HSA-9705714 \"SRD5A3 dehydrogenates TEST to DHTEST\"",
"RHEA:13805",
"RHEA:51048",
"RHEA:51060"
] | [
"GO:0033765"
] | [] | [] | [] | [
"GO:0033765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.99.5",
"skos:exactMatch RHEA:13805",
"skos:narrowMatch RHEA:51048",
"skos:narrowMatch RHEA:51060",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26703\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xsd:anyURI... | null | null | false | true | 3 |
GO:0003866 | 3,866 | 3-phosphoshikimate 1-carboxyvinyltransferase activity | molecular_function | Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate. | [
"EC:2.5.1.19",
"RHEA:21256"
] | null | [
"3-enol-pyruvoylshikimate-5-phosphate synthase activity",
"5-enolpyruvylshikimate-3-phosphate synthase activity",
"EPSP synthase activity",
"phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.5.1.19",
"KEGG_REACTION:R03460",
"MetaCyc:2.5.1.19-RXN",
"RHEA:21256"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.19",
"skos:exactMatch RHEA:21256",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003867 | 3,867 | obsolete 4-aminobutyrate transaminase activity | molecular_function | OBSOLETE. Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. | [
"GOC:mah"
] | The reason for obsoletion is that this term was an unnecessary grouping term. | [
"4-aminobutanoate transaminase activity",
"4-aminobutyrate aminotransferase activity",
"4-aminobutyric acid aminotransferase activity",
"aminobutyrate aminotransferase activity",
"aminobutyrate transaminase activity",
"beta-alanine aminotransferase",
"GABA aminotransferase activity",
"GABA transaminas... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0034386",
"GO:0034387"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28802\" xsd:anyURI"
] | null | null | true | true | 8 |
GO:0003868 | 3,868 | 4-hydroxyphenylpyruvate dioxygenase activity | molecular_function | Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. | [
"EC:1.13.11.27"
] | null | [
"4-hydroxyphenylpyruvate hydroxylase activity",
"4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)",
"4-hydroxyphenylpyruvic acid dioxygenase activity",
"p-hydroxyphenylpyruvate dioxygenase activity",
"p-hydroxyphenylpyruvate hydroxylase activity",
"p-hydroxyphenylpyruvate oxi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.13.11.27",
"MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN",
"Reactome:R-HSA-71163 \"HPD dioxygenates HPP\"",
"RHEA:16189",
"UM-BBD_reactionID:r0298"
] | [
"GO:0016702"
] | [] | [] | [] | [
"GO:0016702"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.13.11.27",
"skos:exactMatch RHEA:16189",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003870 | 3,870 | 5-aminolevulinate synthase activity | molecular_function | Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA. | [
"EC:2.3.1.37",
"RHEA:12921"
] | null | [
"5-aminolevulinate synthetase activity",
"5-aminolevulinic acid synthase activity",
"5-aminolevulinic acid synthetase activity",
"ALA synthase activity",
"ALA synthetase activity",
"ALAS activity",
"alpha-aminolevulinic acid synthase activity",
"aminolevulinate synthase activity",
"aminolevulinate s... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.37",
"KEGG_REACTION:R00830",
"MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN",
"Reactome:R-HSA-189442 \"ALAS condenses SUCC-CoA and Gly to form dALA\"",
"RHEA:12921"
] | [
"GO:0016749"
] | [] | [] | [] | [
"GO:0016749"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.37",
"skos:exactMatch RHEA:12921",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003871 | 3,871 | 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | molecular_function | Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. | [
"EC:2.1.1.14",
"RHEA:21196"
] | null | [
"5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity",
"cobalamin-independent methionine synthase activity",
"homocysteine methylase activity",
"MetE",
"methionine synthase (cobalamin-independent) activity",
"methyltetrahydropteroylpolyglutamate:homocysteine methyltransfer... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.1.14",
"KEGG_REACTION:R04405",
"MetaCyc:HOMOCYSMET-RXN",
"RHEA:21196"
] | [
"GO:0008172"
] | [] | [] | [] | [
"GO:0008172"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.14",
"skos:exactMatch RHEA:21196",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30968\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003872 | 3,872 | 6-phosphofructokinase activity | molecular_function | Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. | [
"EC:2.7.1.11"
] | null | [
"6-phosphofructokinase reduction",
"6-phosphofructose 1-kinase activity",
"ATP-dependent phosphofructokinase activity",
"ATP:D-fructose-6-phosphate 1-phosphotransferase activity",
"D-fructose-6-phosphate 1-phosphotransferase activity",
"fructose 6-phosphate kinase activity",
"fructose 6-phosphokinase ac... | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:2.7.1.11",
"MetaCyc:6PFRUCTPHOS-RXN",
"Reactome:R-HSA-70467 \"PFK tetramer phosphorylates Fru(6)P\"",
"RHEA:16109"
] | [
"GO:0008443"
] | [
"part_of GO:0061615"
] | [
"part_of"
] | [
"GO:0061615"
] | [
"GO:0008443",
"GO:0061615"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.11",
"skos:exactMatch RHEA:16109",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003873 | 3,873 | 6-phosphofructo-2-kinase activity | molecular_function | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+. | [
"EC:2.7.1.105",
"RHEA:15653"
] | null | [
"6-phosphofructo-2-kinase (phosphorylating)",
"6-phosphofructose 2-kinase activity",
"ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity",
"ATP:D-fructose-6-phosphate 2-phosphotransferase activity",
"fructose 6-phosphate 2-kinase activity",
"phosphofructokinase 2 activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.105",
"KEGG_REACTION:R02732",
"MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN",
"Reactome:R-HSA-71802 \"PFKFKB dimer phosphorylates Fru(6)P\"",
"RHEA:15653"
] | [
"GO:0008443"
] | [] | [] | [] | [
"GO:0008443"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.105",
"skos:exactMatch RHEA:15653",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003874 | 3,874 | 6-pyruvoyltetrahydropterin synthase activity | molecular_function | Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate. | [
"EC:4.2.3.12",
"RHEA:22048"
] | null | [
"2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity",
"2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)",
"6-pyruvoyl tetrahydrobiopterin synthase ac... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.2.3.12",
"KEGG_REACTION:R04286",
"MetaCyc:4.2.3.12-RXN",
"Reactome:R-HSA-1474184 \"DHNTP is dephosphorylated by PTPS to PTHP\"",
"RHEA:22048"
] | [
"GO:0016838"
] | [] | [] | [] | [
"GO:0016838"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.3.12",
"skos:exactMatch RHEA:22048",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003875 | 3,875 | ADP-ribosylarginine hydrolase activity | molecular_function | Catalysis of the reactions: H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein], and H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine. | [
"EC:3.2.2.19"
] | null | [
"ADP-ribose-L-arginine cleavage enzyme activity",
"ADP-ribose-L-arginine cleaving enzyme activity",
"ADPribosylarginine hydrolase activity",
"N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity",
"nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity",
"omega-protein-N-(ADP-D-ribos... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.2.19",
"MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN",
"MetaCyc:RXN-8732",
"RHEA:14885",
"RHEA:20784"
] | [
"GO:0016799",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016799",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.2.19",
"skos:narrowMatch MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN",
"skos:narrowMatch MetaCyc:RXN-8732",
"skos:narrowMatch RHEA:14885",
"skos:narrowMatch RHEA:20784",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003876 | 3,876 | AMP deaminase activity | molecular_function | Catalysis of the reaction: AMP + H2O = IMP + NH4+. | [
"RHEA:14777"
] | null | [
"5-adenylate deaminase activity",
"5-adenylic acid deaminase activity",
"5-AMP deaminase activity",
"adenosine 5-monophosphate deaminase activity",
"adenosine 5-phosphate aminohydrolase activity",
"adenosine monophosphate deaminase activity",
"adenyl deaminase activity",
"adenylate aminohydrolase acti... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:3.5.4.6",
"MetaCyc:AMP-DEAMINASE-RXN",
"Reactome:R-HSA-76590 \"AMP + H2O => IMP + NH4+ (AMPD)\"",
"RHEA:14777"
] | [
"GO:0047623"
] | [] | [] | [] | [
"GO:0047623"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.6",
"skos:exactMatch RHEA:14777",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003877 | 3,877 | ATP:ADP adenylyltransferase activity | molecular_function | Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. | [
"EC:2.7.7.53"
] | null | [
"adenine triphosphate adenylyltransferase activity",
"AP-4-A phosphorylase activity",
"ATP adenylyltransferase activity",
"bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity",
"diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity",
"diadenosine 5',5'''-P1,P4-tetraphosphat... | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.53",
"MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN",
"RHEA:16577"
] | [
"GO:0070566"
] | [] | [] | [] | [
"GO:0070566"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.53",
"skos:exactMatch RHEA:16577",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27575\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003878 | 3,878 | ATP citrate synthase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA. | [
"RHEA:21160"
] | Note that this term has a MetaCyc pathway reference as the pathway only has a single step. | [
"acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity",
"acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)",
"acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]",
"adenosine triphosphate citrate lyase ac... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0046913"
] | [] | [
"EC:2.3.3.8",
"KEGG_REACTION:R00352",
"MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN",
"Reactome:R-HSA-75848 \"ACLY tetramer transforms CIT to Ac-CoA\"",
"RHEA:21160"
] | [
"GO:0046912"
] | [] | [] | [] | [
"GO:0046912"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.3.8",
"skos:exactMatch KEGG_REACTION:R00352",
"skos:exactMatch MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN",
"skos:exactMatch RHEA:21160",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-o... | null | null | false | true | 7 |
GO:0003879 | 3,879 | ATP phosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. | [
"EC:2.4.2.17"
] | null | [
"1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity",
"adenosine triphosphate phosphoribosyltransferase activity",
"phosphoribosyl ATP synthetase activity",
"phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity",
"phosphoribosyl-ATP diphosphorylase activity",... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.17",
"MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN",
"RHEA:18473"
] | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.17",
"skos:exactMatch RHEA:18473",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003880 | 3,880 | protein C-terminal carboxyl O-methyltransferase activity | molecular_function | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. | [
"PMID:8428937"
] | null | [
"C-terminal protein carboxyl methyltransferase activity"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0051998"
] | [] | [] | [] | [
"GO:0051998"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0003881 | 3,881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity | molecular_function | Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+. | [
"EC:2.7.8.11",
"RHEA:11580"
] | null | [
"CDP diglyceride-inositol phosphatidyltransferase activity",
"CDP-DG:inositol transferase activity",
"CDP-diacylglycerol--inositol phosphatidyltransferase activity",
"CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity",
"CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:2.7.8.11",
"KEGG_REACTION:R01802",
"MetaCyc:2.7.8.11-RXN",
"Reactome:R-HSA-1482976 \"CDP-DAG is converted to PI by CDIPT\"",
"RHEA:11580"
] | [
"GO:0017169"
] | [] | [] | [] | [
"GO:0017169"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.8.11",
"skos:exactMatch RHEA:11580",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003882 | 3,882 | CDP-diacylglycerol-serine O-phosphatidyltransferase activity | molecular_function | Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. | [
"EC:2.7.8.8"
] | null | [
"CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity",
"CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity",
"CDP-diglyceride-L-serine phosphatidyltransferase activity",
"CDP-diglyceride:serine phosphatidyltransferase activity",
"CDP-diglycerine-serine O-phosphatidyltransferase acti... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:2.7.8.8",
"MetaCyc:PHOSPHASERSYN-RXN",
"RHEA:16913"
] | [
"GO:0017169"
] | [] | [] | [] | [
"GO:0017169"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.8.8",
"skos:exactMatch RHEA:16913",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003883 | 3,883 | CTP synthase activity | molecular_function | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. | [
"PMID:12354108",
"RHEA:26426"
] | null | [
"CTP synthetase activity",
"cytidine 5'-triphosphate synthetase activity",
"cytidine triphosphate synthetase activity",
"uridine triphosphate aminase activity",
"UTP--ammonia ligase activity",
"UTP:ammonia ligase (ADP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.2",
"MetaCyc:CTPSYN-RXN",
"Reactome:R-HSA-504054 \"UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]\"",
"Reactome:R-HSA-73647 \"UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]\"",
"RHEA:26426"
] | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.2",
"skos:exactMatch RHEA:26426",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003884 | 3,884 | D-amino-acid oxidase activity | molecular_function | Catalysis of the reaction: a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4+. | [
"RHEA:21816"
] | null | [
"D-amino-acid:oxygen oxidoreductase (deaminating)",
"L-amino acid:O2 oxidoreductase activity",
"new yellow enzyme"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.4.3.3",
"MetaCyc:D-AMINO-ACID-OXIDASE-RXN",
"Reactome:R-HSA-389821 \"glycine + O2 => glyoxylate + H2O2 + NH4+\"",
"RHEA:21816",
"RHEA:37583",
"RHEA:70951",
"RHEA:70959",
"RHEA:70963",
"RHEA:70971",
"RHEA:78203",
"RHEA:78207",
"RHEA:78211",
"RHEA:78215",
"RHEA:78219",
"RHEA:78223",
... | [
"GO:0008131"
] | [] | [] | [] | [
"GO:0008131"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.4.3.3",
"skos:exactMatch RHEA:21816",
"skos:narrowMatch RHEA:37583",
"skos:narrowMatch RHEA:70951",
"skos:narrowMatch RHEA:70959",
"skos:narrowMatch RHEA:70963",
"skos:narrowMatch RHEA:70971",
"skos:narrowMatch RHEA:78203",
"skos:narrowMatch RHEA:78207",
"skos:narrowMatch RHE... | null | null | false | true | 9 |
GO:0003885 | 3,885 | D-arabinono-1,4-lactone oxidase activity | molecular_function | Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H+. | [
"EC:1.1.3.37",
"RHEA:23756"
] | null | [
"D-arabinono-1,4-lactone:oxygen oxidoreductase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:1.1.3.37",
"KEGG_REACTION:R02715",
"MetaCyc:1.1.3.37-RXN",
"RHEA:23756"
] | [
"GO:0016899"
] | [] | [] | [] | [
"GO:0016899"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.3.37",
"skos:exactMatch RHEA:23756",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003886 | 3,886 | DNA (cytosine-5-)-methyltransferase activity | molecular_function | Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine. | [
"RHEA:13681"
] | null | [
"cytosine 5-methyltransferase activity",
"cytosine DNA methylase activity",
"cytosine DNA methyltransferase activity",
"cytosine-specific DNA methyltransferase activity",
"deoxyribonucleic (cytosine-5-)-methyltransferase activity",
"deoxyribonucleic acid (cytosine-5-)-methyltransferase activity",
"deoxy... | [
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED"
] | [
"GO:0008326"
] | [] | [
"EC:2.1.1.37",
"MetaCyc:DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN",
"RHEA:13681"
] | [
"GO:0008757",
"GO:0009008"
] | [] | [] | [] | [
"GO:0008757",
"GO:0009008"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.37",
"skos:exactMatch MetaCyc:DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN",
"skos:exactMatch RHEA:13681",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28396\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003887 | 3,887 | DNA-directed DNA polymerase activity | molecular_function | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. | [
"EC:2.7.7.7",
"GOC:vw"
] | null | [
"alpha DNA polymerase activity",
"beta DNA polymerase activity",
"delta DNA polymerase activity",
"deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity",
"deoxyribonucleic acid duplicase activity",
"deoxyribonucleic duplicase activity",
"deoxyribonucleic polymerase I",
... | [
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"BROAD",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
... | [
"GO:0003888",
"GO:0003889",
"GO:0003890",
"GO:0003891",
"GO:0003893",
"GO:0003894",
"GO:0003895",
"GO:0008723",
"GO:0015999",
"GO:0016000",
"GO:0016448",
"GO:0016449",
"GO:0016450",
"GO:0016451",
"GO:0016452",
"GO:0019984"
] | [] | [
"EC:2.7.7.7",
"MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN",
"Reactome:R-HSA-110311 \"POLZ extends translesion synthesis\"",
"Reactome:R-HSA-110317 \"Insertion of correct bases opposite the lesion by POLH\"",
"Reactome:R-HSA-110319 \"Elongation by POLH\"",
"Reactome:R-HSA-110368 \"POLD,POLE-mediated DNA stran... | [
"GO:0034061"
] | [] | [] | [] | [
"GO:0034061"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.7",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28442\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003892 | 3,892 | obsolete proliferating cell nuclear antigen | molecular_function | OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair. | [
"ISBN:0123668387"
] | This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. | [
"PCNA",
"proliferating cell nuclear antigen"
] | [
"EXACT",
"EXACT"
] | [
"GO:0005661"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 6 |
GO:0003896 | 3,896 | obsolete DNA primase activity | molecular_function | OBSOLETE. Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer. | [
"GOC:mah",
"GOC:mcc",
"PMID:11395402",
"PMID:26184436",
"PMID:38203225",
"PMID:38492718"
] | The reason for obsoletion is that this term is equivalent to DNA-directed 5'-3' RNA polymerase activity. | [] | [] | [
"GO:0003897",
"GO:0003898"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003899"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23779\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27176\" xsd:anyURI"
] | null | null | true | true | 6 |
GO:0003899 | 3,899 | DNA-directed RNA polymerase activity | molecular_function | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. | [
"EC:2.7.7.6"
] | null | [
"C ribonucleic acid formation factors",
"C RNA formation factors",
"deoxyribonucleic acid-dependent ribonucleic acid polymerase activity",
"DNA-dependent ribonucleate nucleotidyltransferase activity",
"DNA-dependent RNA nucleotidyltransferase activity",
"DNA-dependent RNA polymerase activity",
"DNA-dire... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"BROAD"
] | [
"GO:0000129"
] | [] | [
"EC:2.7.7.6",
"MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN",
"Reactome:R-HSA-111264 \"Addition of nucleotides between position +11 and +30\"",
"Reactome:R-HSA-167113 \"Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition\"",
"Reactome:R-HSA-167115 \"Addition of nucleotides betwee... | [
"GO:0034062"
] | [
"part_of GO:0032774"
] | [
"part_of"
] | [
"GO:0032774"
] | [
"GO:0032774",
"GO:0034062"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.6",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29681\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003900 | 3,900 | obsolete DNA-directed RNA polymerase I activity | molecular_function | OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). | [
"GOC:curators"
] | This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. | [
"DNA-directed RNA polymerase I activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003899"
] | [] | [] | null | null | true | true | 4 |
GO:0003901 | 3,901 | obsolete DNA-directed RNA polymerase II activity | molecular_function | OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). | [
"GOC:curators"
] | This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. | [
"DNA-directed RNA polymerase II activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003899"
] | [] | [] | null | null | true | true | 9 |
GO:0003904 | 3,904 | deoxyribodipyrimidine photo-lyase activity | molecular_function | Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. | [
"EC:4.1.99.3"
] | null | [
"CPD photolyase activity",
"deoxyribocyclobutadipyrimidine pyrimidine-lyase activity",
"deoxyribodipyrimidine photolyase activity",
"deoxyribonucleate pyrimidine dimer lyase (photosensitive)",
"deoxyribonucleic cyclobutane dipyrimidine photolyase activity",
"deoxyribonucleic photolyase activity",
"dipyr... | [
"EXACT",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.99.3",
"MetaCyc:RXN-19243",
"MetaCyc:RXN-19244",
"RHEA:10672"
] | [
"GO:0003913"
] | [] | [] | [] | [
"GO:0003913"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.99.3",
"skos:exactMatch RHEA:10672",
"skos:narrowMatch MetaCyc:RXN-19243",
"skos:narrowMatch MetaCyc:RXN-19244",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/3019... | null | null | false | true | 7 |
GO:0003905 | 3,905 | alkylbase DNA N-glycosylase activity | molecular_function | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. | [
"EC:3.2.2.21",
"GOC:elh",
"PMID:10872450",
"PMID:9224623"
] | null | [
"3-methyladenine DNA glycosylase II",
"AlkA",
"alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)",
"alkylbase DNA glycosidase activity",
"deoxyribonucleate 3-methyladenine glycosidase II",
"DNA glycosidase II activity",
"DNA-3-methyladenine glycosidase II activity",
"DNA-3-methy... | [
"RELATED",
"RELATED",
"BROAD",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED"
] | [
"GO:0004036"
] | [] | [
"EC:3.2.2.21",
"MetaCyc:3.2.2.21-RXN"
] | [
"GO:0019104"
] | [] | [] | [] | [
"GO:0019104"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.2.21",
"skos:exactMatch MetaCyc:3.2.2.21-RXN",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003906 | 3,906 | DNA-(apurinic or apyrimidinic site) endonuclease activity | molecular_function | Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). | [
"Wikipedia:AP_endonuclease"
] | null | [
"abasic deoxyendoribonuclease activity",
"AP deoxyendoribonuclease activity",
"apurinic deoxyendoribonuclease activity",
"apurinic/apyrimidinic endodeoxyribonuclease activity",
"apyrimidinic deoxyendoribonuclease activity",
"deoxyribonuclease (apurinic or apyrimidinic) activity",
"endonuclease VIII acti... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"BROAD"
] | [] | [] | [
"Reactome:R-HSA-110375 \"Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break\"",
"Reactome:R-HSA-5649711 \"NEIL1,NEIL2 incises DNA strand 5' to the AP site\"",
"Reactome:R-HSA-5649725 \"POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)\""
] | [
"GO:0004520"
] | [] | [] | [] | [
"GO:0004520"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15308\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15357\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22262\" xsd:anyURI",
"term_tracker_item \"https://gi... | null | null | false | true | 5 |
GO:0003908 | 3,908 | methylated-DNA-[protein]-cysteine S-methyltransferase activity | molecular_function | Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. | [
"EC:2.1.1.63"
] | null | [
"6-O-methylguanine-DNA methyltransferase activity",
"DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity",
"DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity",
"methylated-DNA-protein-cysteine S-methyltransferase activity",
"MGMT",
"O-6-methylguanine-DNA-alkyltransf... | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:2.1.1.63",
"MetaCyc:2.1.1.63-RXN",
"Reactome:R-HSA-73892 \"MGMT/hAGT mediated DNA Damage Reversal\"",
"RHEA:24000"
] | [
"GO:0008172",
"GO:0008276"
] | [] | [] | [] | [
"GO:0008172",
"GO:0008276"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.1.63",
"skos:exactMatch RHEA:24000",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26174\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003909 | 3,909 | DNA ligase activity | molecular_function | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. | [
"ISBN:0716720094"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-174456 \"Joining of adjacent Okazaki fragments of the C-strand\"",
"Reactome:R-HSA-175258 \"2-LTR formation due to circularization of viral DNA\"",
"Reactome:R-HSA-5358592 \"DNA ligase I ligates single stranded nick in double stranded DNA\"",
"Reactome:R-HSA-5649734 \"LIG3 ligates NEIL1,NEIL2-... | [
"GO:0016886",
"GO:0140097"
] | [] | [] | [] | [
"GO:0016886",
"GO:0140097"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0003910 | 3,910 | DNA ligase (ATP) activity | molecular_function | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). | [
"EC:6.5.1.1"
] | null | [
"deoxyribonucleate ligase",
"deoxyribonucleic acid joinase",
"deoxyribonucleic acid ligase",
"deoxyribonucleic acid repair enzyme",
"deoxyribonucleic acid-joining enzyme",
"deoxyribonucleic joinase",
"deoxyribonucleic ligase",
"deoxyribonucleic repair enzyme",
"deoxyribonucleic-joining enzyme",
"D... | [
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.5.1.1",
"MetaCyc:DNA-LIGASE-ATP-RXN",
"Reactome:R-HSA-9914903 \"LIG3 (Ligase III) ligates nascent mitochondrial DNA strands\""
] | [
"GO:0003909"
] | [] | [] | [] | [
"GO:0003909"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.5.1.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003911 | 3,911 | DNA ligase (NAD+) activity | molecular_function | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). | [
"EC:6.5.1.2"
] | null | [
"deoxyribonucleate ligase",
"deoxyribonucleic acid joinase",
"deoxyribonucleic acid ligase",
"deoxyribonucleic joinase",
"deoxyribonucleic ligase",
"deoxyribonucleic repair enzyme",
"deoxyribonucleic-joining enzyme",
"DNA joinase activity",
"DNA ligase (NAD)",
"DNA repair enzyme activity",
"DNA-... | [
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.5.1.2",
"MetaCyc:DNA-LIGASE-NAD+-RXN"
] | [
"GO:0003909"
] | [] | [] | [] | [
"GO:0003909"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.5.1.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003912 | 3,912 | DNA nucleotidylexotransferase activity | molecular_function | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. | [
"EC:2.7.7.31"
] | null | [
"addase activity",
"deoxynucleotidyl terminal transferase activity",
"deoxyribonucleic acid nucleotidyltransferase activity",
"deoxyribonucleic nucleotidyltransferase activity",
"nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity",
"TdT",
"terminal addition enzyme activity",
"terminal... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.31",
"MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN"
] | [
"GO:0034061"
] | [] | [] | [] | [
"GO:0034061"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.31",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28442\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003913 | 3,913 | DNA photolyase activity | molecular_function | Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. | [
"GOC:mah",
"PMID:11124949"
] | null | [] | [] | [] | [] | [] | [
"GO:0016830",
"GO:0140097"
] | [] | [] | [] | [
"GO:0016830",
"GO:0140097"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003914 | 3,914 | DNA (6-4) photolyase activity | molecular_function | Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. | [
"GOC:mah",
"PMID:11124949"
] | null | [] | [] | [] | [] | [
"EC:4.1.99.13",
"MetaCyc:RXN-10771"
] | [
"GO:0003913"
] | [] | [] | [] | [
"GO:0003913"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.99.13",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003916 | 3,916 | DNA topoisomerase activity | molecular_function | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. | [
"GOC:mah",
"PMID:8811192"
] | null | [] | [] | [
"GO:0009387"
] | [] | [] | [
"GO:0120545",
"GO:0140097"
] | [
"has_part GO:0003677"
] | [
"has_part"
] | [
"GO:0003677"
] | [
"GO:0003677",
"GO:0120545",
"GO:0140097"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23524\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29690\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003918 | 3,918 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | molecular_function | Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in... | [
"PMID:8811192"
] | null | [
"deoxyribonucleate topoisomerase",
"deoxyribonucleic topoisomerase activity",
"DNA topoisomerase (ATP-hydrolysing)",
"DNA topoisomerase II",
"DNA topoisomerase II activity",
"DNA topoisomerase IV activity",
"DNA topoisomerase type II activity",
"topoisomerase",
"topoisomerase II",
"type II DNA top... | [
"BROAD",
"BROAD",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"EXACT",
"BROAD",
"NARROW",
"RELATED"
] | [
"GO:0061505"
] | [] | [
"EC:5.6.2.2",
"MetaCyc:5.99.1.3-RXN",
"Wikipedia:Type_II_topoisomerase"
] | [
"GO:0003916",
"GO:0008094"
] | [] | [] | [] | [
"GO:0003916",
"GO:0008094"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.6.2.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/15575\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17661\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003919 | 3,919 | FMN adenylyltransferase activity | molecular_function | Catalysis of the reaction: ATP + FMN = diphosphate + FAD. | [
"EC:2.7.7.2",
"RHEA:17237"
] | null | [
"adenosine triphosphate-riboflavin mononucleotide transadenylase activity",
"adenosine triphosphate-riboflavine mononucleotide transadenylase activity",
"ATP:FMN adenylyltransferase activity",
"FAD diphosphorylase activity",
"FAD pyrophosphorylase activity",
"FAD synthetase activity",
"flavin adenine di... | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.2",
"KEGG_REACTION:R00161",
"MetaCyc:FADSYN-RXN",
"Reactome:R-HSA-196929 \"FLAD1 phosphorylates FMN\"",
"RHEA:17237"
] | [
"GO:0070566"
] | [] | [] | [] | [
"GO:0070566"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.2",
"skos:exactMatch RHEA:17237",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003920 | 3,920 | GMP reductase activity | molecular_function | Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH. | [
"EC:1.7.1.7",
"RHEA:17185"
] | null | [
"guanosine 5'-monophosphate oxidoreductase activity",
"guanosine 5'-monophosphate reductase activity",
"guanosine 5'-phosphate reductase activity",
"guanosine monophosphate reductase activity",
"guanylate reductase activity",
"inosine-5'-phosphate:NADP+ oxidoreductase (aminating)",
"NADPH2:guanosine-5'-... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.7.1.7",
"KEGG_REACTION:R01134",
"MetaCyc:GMP-REDUCT-RXN",
"Reactome:R-HSA-514604 \"GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)\"",
"RHEA:17185"
] | [
"GO:0046857"
] | [] | [] | [] | [
"GO:0046857"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.7.1.7",
"skos:exactMatch RHEA:17185",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003921 | 3,921 | GMP synthase activity | molecular_function | Catalysis of the reaction: ATP + XMP + NH4+ = AMP + diphosphate + GMP + 2H+. | [
"RHEA:18301"
] | null | [] | [] | [] | [] | [
"MetaCyc:GMP-SYN-NH3-RXN",
"RHEA:18301"
] | [
"GO:0016879"
] | [
"part_of GO:0003922"
] | [
"part_of"
] | [
"GO:0003922"
] | [
"GO:0003922",
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:18301",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003922 | 3,922 | GMP synthase (glutamine-hydrolyzing) activity | molecular_function | Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+. | [
"RHEA:11680"
] | null | [
"glutamine amidotransferase activity",
"GMP synthase (glutamine-hydrolysing)",
"GMP synthetase (glutamine-hydrolysing)",
"GMP synthetase (glutamine-hydrolyzing) activity",
"guanosine 5'-monophosphate synthetase activity",
"guanosine monophosphate synthetase (glutamine-hydrolyzing)",
"guanylate synthetas... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.5.2",
"MetaCyc:GMP-SYN-GLUT-RXN",
"Reactome:R-HSA-73792 \"XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate\"",
"Reactome:R-HSA-9748957 \"GMPS dimer transforms 6TXMP to 6TGMP\"",
"RHEA:11680",
"Wikipedia:GMP_synthase_(glutamine-hydrolysing)"
] | [
"GO:0016884"
] | [
"part_of GO:0006177"
] | [
"part_of"
] | [
"GO:0006177"
] | [
"GO:0006177",
"GO:0016884"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.5.2",
"skos:exactMatch RHEA:11680",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003923 | 3,923 | GPI-anchor transamidase activity | molecular_function | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. | [
"ISBN:0471331309"
] | null | [] | [] | [] | [] | [
"Reactome:R-HSA-162836 \"uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide\""
] | [
"GO:0004197",
"GO:0016769"
] | [] | [] | [] | [
"GO:0004197",
"GO:0016769"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28258\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003924 | 3,924 | GTPase activity | molecular_function | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. | [
"PMID:26832457",
"PMID:27218782"
] | null | [
"ARF small monomeric GTPase activity",
"dynamin GTPase activity",
"GTPase activity, coupled",
"heterotrimeric G-protein GTPase activity",
"heterotrimeric G-protein GTPase, alpha-subunit",
"heterotrimeric G-protein GTPase, beta-subunit",
"heterotrimeric G-protein GTPase, gamma-subunit",
"hydrolase acti... | [
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0061745"
] | [
"goslim_chembl",
"goslim_drosophila",
"goslim_generic",
"goslim_prokaryote",
"goslim_yeast"
] | [
"MetaCyc:RXN0-5462",
"Reactome:R-HSA-1445143 \"RAB8A,10,13,14 hydrolyze GTP\"",
"Reactome:R-HSA-1458485 \"RALA hydrolyzes GTP\"",
"Reactome:R-HSA-156923 \"Hydrolysis of eEF1A:GTP\"",
"Reactome:R-HSA-164381 \"G alpha (s) auto-inactivates by hydrolysing GTP to GDP\"",
"Reactome:R-HSA-165055 \"Hydrolysis of ... | [
"GO:0017111"
] | [] | [] | [] | [
"GO:0017111"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:19669",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19078\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26014\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | dph | 2015-11-11T12:47:56Z | false | true | 7 |
GO:0003925 | 3,925 | G protein activity | molecular_function | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by ... | [
"PMID:16923326",
"PMID:24470015"
] | null | [
"heterotrimeric G-protein GTPase activity",
"large G-protein activity",
"large G-protein GTPase activity",
"Ras superfamily protein",
"signaling G protein activity",
"small G-protein",
"small GTPase",
"small GTPase activity",
"small monomeric G protein activity",
"small monomeric GTPase activity"
... | [
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0003927"
] | [] | [
"EC:3.6.5.1",
"EC:3.6.5.2",
"Reactome:R-HSA-400027 \"Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma\"",
"Reactome:R-HSA-422320 \"Heterotrimeric G(s) complex dissociates\""
] | [
"GO:0003924",
"GO:0098772"
] | [] | [] | [] | [
"GO:0003924",
"GO:0098772"
] | [] | [] | [] | [] | [] | [
"skos:narrowMatch EC:3.6.5.1",
"skos:narrowMatch EC:3.6.5.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19082\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26014\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003926 | 3,926 | obsolete ARF small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | [
"EC:3.6.1.47"
] | This term was made obsolete because it represents a gene product. | [
"ARF small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 4 |
GO:0003928 | 3,928 | obsolete RAB small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | [
"EC:3.6.1.47"
] | This term was made obsolete because it represents a gene product. | [
"RAB small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 5 |
GO:0003929 | 3,929 | obsolete RAN small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | [
"EC:3.6.1.47"
] | This term was made obsolete because it represents a gene product. | [
"RAN small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 2 |
GO:0003930 | 3,930 | obsolete RAS small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | [
"EC:3.6.1.47"
] | This term was made obsolete because it represents a gene product. | [
"RAS small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 7 |
GO:0003931 | 3,931 | obsolete Rho small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. | [
"EC:3.6.1.47",
"GOC:mah",
"ISBN:0198547684"
] | This term was made obsolete because it represents a gene product. | [
"Rho small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 9 |
GO:0003932 | 3,932 | obsolete SAR small monomeric GTPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | [
"EC:3.6.1.47"
] | This term was made obsolete because it represents a gene product. | [
"SAR small monomeric GTPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003924"
] | [] | [] | null | null | true | true | 4 |
GO:0003933 | 3,933 | GTP cyclohydrolase activity | molecular_function | Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [] | [
"GO:0019238"
] | [] | [] | [] | [
"GO:0019238"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26710\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003934 | 3,934 | GTP cyclohydrolase I activity | molecular_function | Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. | [
"EC:3.5.4.16"
] | null | [
"dihydroneopterin triphosphate synthase activity",
"GTP 7,8-8,9-dihydrolase activity",
"GTP 8-formylhydrolase activity",
"guanosine triphosphate 8-deformylase activity",
"guanosine triphosphate cyclohydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.16",
"KEGG_REACTION:R00424",
"MetaCyc:GTP-CYCLOHYDRO-I-RXN",
"Reactome:R-HSA-1474146 \"GCH1 reduces GTP to dihydroneopterin triphosphate\"",
"RHEA:17473"
] | [
"GO:0003933"
] | [] | [] | [] | [
"GO:0003933"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.16",
"skos:exactMatch RHEA:17473",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26710\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003935 | 3,935 | GTP cyclohydrolase II activity | molecular_function | Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate. | [
"EC:3.5.4.25",
"RHEA:23704"
] | null | [
"GTP 7,8-8,9-dihydrolase (diphosphate-forming)",
"GTP-8-formylhydrolase activity",
"guanosine triphosphate cyclohydrolase II"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.25",
"KEGG_REACTION:R00425",
"MetaCyc:GTP-CYCLOHYDRO-II-RXN",
"RHEA:23704"
] | [
"GO:0003933"
] | [] | [] | [] | [
"GO:0003933"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.25",
"skos:exactMatch RHEA:23704",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26710\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003936 | 3,936 | obsolete hydrogen-transporting two-sector ATPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). | [
"EC:3.6.3.14",
"TC:3.A.3.-.-"
] | This term was made obsolete because it refers to a bifunctional gene product. | [
"hydrogen-transporting two-sector ATPase activity",
"proton-transporting two-sector ATPase activity"
] | [
"EXACT",
"EXACT"
] | [
"GO:0004006",
"GO:0008729"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0046933",
"GO:0046961"
] | [] | null | null | true | true | 7 |
GO:0003937 | 3,937 | IMP cyclohydrolase activity | molecular_function | Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. | [
"EC:3.5.4.10"
] | null | [
"IMP 1,2-hydrolase (decyclizing)",
"IMP synthetase activity",
"inosinate cyclohydrolase activity",
"inosinicase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.4.10",
"MetaCyc:IMPCYCLOHYDROLASE-RXN",
"Reactome:R-HSA-73797 \"FAICAR => IMP + H2O\"",
"RHEA:18445"
] | [
"GO:0019238"
] | [] | [] | [] | [
"GO:0019238"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.4.10",
"skos:exactMatch RHEA:18445",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003938 | 3,938 | IMP dehydrogenase activity | molecular_function | Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. | [
"EC:1.1.1.205"
] | null | [
"IMP oxidoreductase activity",
"IMP:NAD+ oxidoreductase activity",
"inosinate dehydrogenase activity",
"inosine 5'-monophosphate dehydrogenase activity",
"inosine monophosphate dehydrogenase activity",
"inosine monophosphate oxidoreductase activity",
"inosine-5'-phosphate dehydrogenase activity",
"ino... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.1.1.205",
"MetaCyc:IMP-DEHYDROG-RXN",
"Reactome:R-HSA-73794 \"IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]\"",
"Reactome:R-HSA-9748945 \"IMPDH tetramers dehydrogenate 6TIMP to 6TXMP\"",
"RHEA:11708"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.205",
"skos:exactMatch RHEA:11708",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003939 | 3,939 | L-iditol 2-dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. | [
"EC:1.1.1.14",
"PMID:13373783"
] | null | [
"glucitol dehydrogenase activity",
"L-iditol (sorbitol) dehydrogenase activity",
"L-iditol:NAD oxidoreductase activity",
"L-iditol:NAD+ 5-oxidoreductase activity",
"NAD+-dependent sorbitol dehydrogenase activity",
"NAD-dependent sorbitol dehydrogenase activity",
"NAD-sorbitol dehydrogenase",
"polyol d... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.1.1.14",
"MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN",
"Reactome:R-HSA-5652195 \"SORD oxidizes D-sorbitol to Fru\"",
"RHEA:10160",
"RHEA:33031"
] | [
"GO:0004022"
] | [] | [] | [] | [
"GO:0004022"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.14",
"skos:narrowMatch RHEA:10160",
"skos:narrowMatch RHEA:33031",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28432\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003940 | 3,940 | L-iduronidase activity | molecular_function | Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. Can also hydrolyze alpha-L-iduronosidic linkages in heparan sulfate. | [
"EC:3.2.1.76",
"PMID:35011691"
] | null | [
"alpha-L-iduronidase activity",
"glycosaminoglycan alpha-L-iduronohydrolase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.2.1.76",
"MetaCyc:3.2.1.76-RXN",
"Reactome:R-HSA-1678716 \"IDUA cleaves iduronate from HS chain\"",
"Reactome:R-HSA-1793186 \"IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS\"",
"Reactome:R-HSA-2090037 \"IDUA hydrolyses Heparan sulfate chain(6)\"",
"Reactome:R-HSA-2206299 \"Defective ... | [
"GO:0004553"
] | [] | [] | [] | [
"GO:0004553"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.2.1.76",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28907\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003941 | 3,941 | L-serine ammonia-lyase activity | molecular_function | Catalysis of the reaction: L-serine = pyruvate + NH4+. | [
"RHEA:19169"
] | null | [
"L-hydroxyaminoacid dehydratase activity",
"L-serine ammonia-lyase (pyruvate-forming) activity",
"L-serine deaminase activity",
"L-serine dehydratase activity",
"L-serine dehydration activity",
"L-serine hydro-lyase (deaminating) activity",
"serine deaminase activity"
] | [
"BROAD",
"RELATED",
"EXACT",
"BROAD",
"RELATED",
"EXACT",
"BROAD"
] | [] | [] | [
"EC:4.3.1.17",
"MetaCyc:4.3.1.17-RXN",
"Reactome:R-HSA-9929460 \"SDS dimers:PXLP convert L-Ser to PYR and NH4+\"",
"RHEA:19169"
] | [
"GO:0016841"
] | [] | [] | [] | [
"GO:0016841"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.3.1.17",
"skos:exactMatch RHEA:19169",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003942 | 3,942 | N-acetyl-gamma-glutamyl-phosphate reductase activity | molecular_function | Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. | [
"RHEA:21588"
] | null | [
"N-acetyl-glutamate semialdehyde dehydrogenase activity",
"N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)",
"N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)",
"N-acetylglutamate 5-semialdehyde dehydrogenase activity",
"N-acetylglutamic gamma-semial... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.2.1.38",
"MetaCyc:N-ACETYLGLUTPREDUCT-RXN",
"RHEA:21588"
] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.38",
"skos:exactMatch RHEA:21588",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003943 | 3,943 | N-acetylgalactosamine-4-sulfatase activity | molecular_function | Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. | [
"EC:3.1.6.12"
] | null | [
"acetylgalactosamine 4-sulfatase activity",
"arylsulfatase B",
"chondroitinsulfatase",
"N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity",
"N-acetylgalactosamine 4-sulfate sulfohydrolase activity",
"N-acetylgalactosamine-4-sulphatase activity"
] | [
"RELATED",
"EXACT",
"BROAD",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.1.6.12",
"MetaCyc:3.1.6.12-RXN",
"Reactome:R-HSA-1606789 \"ARSB hydrolyses DS\"",
"Reactome:R-HSA-1793207 \"ARSB hydrolyses C4S/C6S chains\"",
"Reactome:R-HSA-2282889 \"Defective ARSB does not hydrolyse C4S/C6S chains\"",
"Reactome:R-HSA-9036065 \"Defective ARSB does not hydrolyse DS\"",
"Wikipedi... | [
"GO:0008484"
] | [] | [] | [] | [
"GO:0008484"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.6.12",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003945 | 3,945 | N-acetyllactosamine synthase activity | molecular_function | Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. | [
"EC:2.4.1.90"
] | null | [
"acetyllactosamine synthetase activity",
"beta-(1,4)-galactosyltransferase activity",
"beta-1,4-galactosyltransferase activity",
"beta-1,4-GalT",
"beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity",
"Gal-T",
"lactosamine synthase activity",
"lactosamine synthetase activity",
"lactos... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELAT... | [] | [] | [
"EC:2.4.1.90",
"MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN",
"RHEA:17745"
] | [
"GO:0035250"
] | [] | [] | [] | [
"GO:0035250"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.1.90",
"skos:exactMatch RHEA:17745",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003948 | 3,948 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | molecular_function | Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+. | [
"EC:3.5.1.26",
"RHEA:11544"
] | null | [
"4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity",
"aspartylglucosaminidase activity",
"aspartylglucosylaminase activity",
"aspartylglucosylamine deaspartylase activity",
"aspartylglucosylaminidase activity",
"aspartylglycosylamine amidohydrolase activity",
"beta-aspartylglucosyl... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.26",
"KEGG_REACTION:R03421",
"MetaCyc:3.5.1.26-RXN",
"RHEA:11544"
] | [
"GO:0016811"
] | [] | [] | [] | [
"GO:0016811"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.26",
"skos:exactMatch RHEA:11544",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003949 | 3,949 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity | molecular_function | Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. | [
"EC:5.3.1.16",
"RHEA:15469"
] | null | [
"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity",
"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity",
"N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imid... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.3.1.16",
"KEGG_REACTION:R04640",
"MetaCyc:PRIBFAICARPISOM-RXN",
"RHEA:15469"
] | [
"GO:0016861"
] | [] | [] | [] | [
"GO:0016861"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.3.1.16",
"skos:exactMatch RHEA:15469",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003950 | 3,950 | NAD+ poly-ADP-ribosyltransferase activity | molecular_function | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. | [
"EC:2.4.2.30"
] | null | [
"ADP-ribosyltransferase (polymerizing) activity",
"NAD ADP-ribosyltransferase activity",
"NAD+ ADP-ribosyltransferase activity",
"NAD+-protein poly-ADP-ribosyltransferase activity",
"NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity",
"poly(adenosine diphosphate ribose) ... | [
"RELATED",
"EXACT",
"BROAD",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.30",
"MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN",
"Reactome:R-HSA-2187325 \"PARP1 ADP-ribosylates SMAD3 and SMAD4\"",
"Reactome:R-HSA-3640858 \"Tankyrase ADP-ribosylates AXIN\"",
"Reactome:R-HSA-5651723 \"PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate\"",
"Reactome:R-HSA-5687653 \"PARP1,PA... | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.30",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29560\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003951 | 3,951 | NAD+ kinase activity | molecular_function | Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. | [
"RHEA:18629"
] | null | [
"ATP:NAD+ 2'-phosphotransferase activity",
"DPN kinase activity",
"NAD kinase activity",
"NADK",
"nicotinamide adenine dinucleotide kinase (phosphorylating)",
"nicotinamide adenine dinucleotide kinase activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.23",
"KEGG_REACTION:R00104",
"MetaCyc:NAD-KIN-RXN",
"Reactome:R-HSA-197198 \"NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+\"",
"Reactome:R-HSA-8955030 \"NADK2 dimer phosphorylates NAD+ to NADP+\"",
"RHEA:18629"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.23",
"skos:exactMatch RHEA:18629",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28752\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003952 | 3,952 | NAD+ synthase (glutamine-hydrolyzing) activity | molecular_function | Catalysis of the reaction: deamido-NAD+ + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD+ + H+. | [
"RHEA:24384"
] | null | [
"deamido-NAD+:L-glutamine amido-ligase (AMP-forming)",
"desamidonicotinamide adenine dinucleotide amidotransferase activity",
"DPN synthetase activity",
"NAD synthase (glutamine-hydrolyzing) activity",
"NAD synthetase (glutamine-hydrolysing)",
"NAD(+) synthetase (glutamine-hydrolyzing) activity",
"NAD+ ... | [
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.5.1",
"MetaCyc:NAD-SYNTH-GLN-RXN",
"Reactome:R-HSA-197271 \"NADSYN1 hexamer amidates NAAD to NAD+\"",
"RHEA:24384",
"Wikipedia:NAD+_synthase_(glutamine-hydrolysing)"
] | [
"GO:0016884"
] | [] | [] | [] | [
"GO:0016884"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.5.1",
"skos:exactMatch MetaCyc:NAD-SYNTH-GLN-RXN",
"skos:exactMatch RHEA:24384",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29467\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003953 | 3,953 | NAD+ nucleosidase activity | molecular_function | Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+. | [
"PMID:11866528",
"PMID:7805847",
"RHEA:16301"
] | null | [
"beta-NAD(+) glycohydrolase activity",
"diphosphopyridine nucleosidase activity",
"DPNase activity",
"NAD glycohydrolase activity",
"NAD nucleosidase activity",
"NAD(+) glycohydrolase activity",
"NADase activity",
"nicotinamide adenine dinucleotide glycohydrolase activity",
"nicotinamide adenine din... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:3.2.2.5",
"MetaCyc:RXN-13859"
] | [
"GO:0016799"
] | [] | [] | [] | [
"GO:0016799"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch RHEA:16301",
"skos:exactMatch EC:3.2.2.5",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26011\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003954 | 3,954 | NADH dehydrogenase activity | molecular_function | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. | [
"RHEA:11356"
] | null | [
"beta-NADH dehydrogenase dinucleotide activity",
"cytochrome c reductase activity",
"diaphorase activity",
"dihydrocodehydrogenase I dehydrogenase activity",
"dihydronicotinamide adenine dinucleotide dehydrogenase activity",
"diphosphopyridine diaphorase activity",
"diphosphopyrinase activity",
"DPNH ... | [
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"RHEA:11356",
"RHEA:30147",
"RHEA:47524"
] | [
"GO:0016651"
] | [] | [] | [] | [
"GO:0016651"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:11356",
"skos:narrowMatch RHEA:30147",
"skos:narrowMatch RHEA:47524",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003955 | 3,955 | NAD(P)H dehydrogenase (quinone) activity | molecular_function | Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. | [
"EC:1.6.5.2"
] | null | [
"azoreductase activity",
"dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity",
"diaphorase activity",
"DT-diaphorase activity",
"flavoprotein NAD(P)H-quinone reductase activity",
"menadione oxidoreductase activity",
"menadione reductase activity",
"NAD(P)H dehydroge... | [
"BROAD",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW... | [] | [] | [
"EC:1.6.5.2",
"MetaCyc:NQOR-RXN",
"UM-BBD_reactionID:r0227"
] | [
"GO:0016655"
] | [] | [] | [] | [
"GO:0016655"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.6.5.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20616\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003957 | 3,957 | NAD(P)+ transhydrogenase (Si-specific) activity | molecular_function | Catalysis of the reaction: NADPH + NAD+ = NADP+ + NADH. | [
"RHEA:11692"
] | null | [
"H+-thase",
"NAD transhydrogenase",
"NAD(P) transhydrogenase (B-specific) activity",
"NAD(P)+ transhydrogenase (B-specific) activity",
"NADH transhydrogenase",
"NADH-NADP-transhydrogenase",
"NADPH-NAD oxidoreductase",
"NADPH-NAD transhydrogenase",
"NADPH:NAD+ oxidoreductase (B-specific)",
"NADPH:N... | [
"BROAD",
"BROAD",
"EXACT",
"EXACT",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"BROAD",
"BROAD"
] | [] | [] | [
"EC:1.6.1.1",
"Reactome:R-HSA-450971 \"NNT dimer transfers proton from NADPH to NAD+\"",
"RHEA:11692"
] | [
"GO:0016652"
] | [] | [] | [] | [
"GO:0016652"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch KEGG_REACTION:R00112",
"skos:broadMatch MetaCyc:PYRNUTRANSHYDROGEN-RXN",
"skos:exactMatch EC:1.6.1.1",
"skos:exactMatch RHEA:11692",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27814\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolog... | null | null | false | true | 9 |
GO:0003958 | 3,958 | NADPH-hemoprotein reductase activity | molecular_function | Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. | [
"EC:1.6.2.4"
] | null | [
"aldehyde reductase (NADPH-dependent) activity",
"CPR activity",
"cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity",
"cytochrome P-450 reductase activity",
"cytochrome P450 reductase activity",
"dihydroxynicotinamide adenine dinucleotide phospha... | [
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"NARROW",... | [] | [] | [
"EC:1.6.2.4",
"MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN",
"Reactome:R-HSA-76494 \"POR reduces CYP450:Fe3+ to CYP450:Fe2+\"",
"RHEA:24040"
] | [
"GO:0016653"
] | [] | [] | [] | [
"GO:0016653"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.6.2.4",
"skos:exactMatch RHEA:24040",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
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