go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0003959 | 3,959 | NADPH dehydrogenase activity | molecular_function | Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. | [
"RHEA:13149"
] | null | [
"dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity",
"NADPH diaphorase activity",
"NADPH-dehydrogenase activity",
"NADPH2 diaphorase activity",
"NADPH2-dehydrogenase activity",
"NADPH:(acceptor) oxidoreductase activity",
"NADPH:acceptor oxidoreductase activity",
"old yellow enz... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0008468",
"GO:0016660"
] | [] | [
"EC:1.6.99.1",
"MetaCyc:NADPH-DEHYDROGENASE-RXN",
"Reactome:R-HSA-9018867 \"5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2\"",
"Reactome:R-HSA-9018901 \"5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2\"",
"RHEA:13149",
"RHEA:30151"
] | [
"GO:0016651"
] | [] | [] | [] | [
"GO:0016651"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.6.99.1",
"skos:exactMatch RHEA:13149",
"skos:narrowMatch RHEA:30151"
] | null | null | false | true | 5 |
GO:0003960 | 3,960 | quinone reductase (NADPH) activity | molecular_function | Catalysis of the reaction: 2 a quinone + NADPH + H+ = 2 a 1,4-benzosemiquinone + NADP+. | [
"RHEA:14269"
] | null | [
"NADPH:quinone oxidoreductase activity",
"NADPH:quinone reductase activity",
"quinone oxidoreductase activity",
"zeta-crystallin activity"
] | [
"RELATED",
"EXACT",
"BROAD",
"NARROW"
] | [] | [] | [
"EC:1.6.5.5",
"MetaCyc:QOR-RXN",
"Reactome:R-HSA-6799722 \"TP53I3 oxidoreductase generates unstable semiquinones\"",
"RHEA:14269"
] | [
"GO:0003959",
"GO:0016655"
] | [] | [] | [] | [
"GO:0003959",
"GO:0016655"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.6.5.5",
"skos:exactMatch RHEA:14269",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30386\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003961 | 3,961 | O-acetylhomoserine aminocarboxypropyltransferase activity | molecular_function | Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers. | [
"EC:2.5.1.49"
] | null | [
"L-methionine anabolism, direct, from O-acetyl-L-homoserine",
"L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine",
"L-methionine formation, direct, from O-acetyl-L-homoserine",
"L-methionine synthesis, direct, from O-acetyl-L-homoserine",
"methionine biosynthetic process, direct, from O-... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [
"GO:0019282"
] | [] | [
"EC:2.5.1.49",
"MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN",
"RHEA:10048"
] | [
"GO:0016765"
] | [
"part_of GO:0071266"
] | [
"part_of"
] | [
"GO:0071266"
] | [
"GO:0016765",
"GO:0071266"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.49",
"skos:narrowMatch RHEA:10048",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28681\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0003962 | 3,962 | cystathionine gamma-synthase activity | molecular_function | Catalysis of the reaction: L-cysteine + O-succinyl-L-homoserine = H+ + L,L-cystathionine + succinate. | [
"RHEA:20397"
] | null | [
"CTT gamma synthase activity",
"cystathionine g-synthase activity",
"cystathionine gamma synthase activity",
"cystathionine gamma-synthase activity (acts on O-phosphohomoserine)",
"cystathionine synthase activity",
"cystathionine synthetase activity",
"homoserine O-transsuccinylase activity",
"homoser... | [
"EXACT",
"EXACT",
"EXACT",
"NARROW",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"EXACT",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0000505"
] | [] | [
"EC:2.5.1.48",
"MetaCyc:O-SUCCHOMOSERLYASE-RXN",
"RHEA:20397"
] | [
"GO:0016765"
] | [] | [] | [] | [
"GO:0016765"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.5.1.48",
"skos:exactMatch MetaCyc:O-SUCCHOMOSERLYASE-RXN",
"skos:exactMatch RHEA:20397",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28811\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003963 | 3,963 | RNA-3'-phosphate cyclase activity | molecular_function | Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. | [
"EC:6.5.1.4"
] | null | [
"RNA 3'-terminal phosphate cyclase activity",
"RNA cyclase activity",
"RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.5.1.4",
"MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN",
"RHEA:23976"
] | [
"GO:0009975",
"GO:0016886",
"GO:0140098"
] | [] | [] | [] | [
"GO:0009975",
"GO:0016886",
"GO:0140098"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.5.1.4",
"skos:exactMatch RHEA:23976",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003964 | 3,964 | RNA-directed DNA polymerase activity | molecular_function | Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. | [
"EC:2.7.7.49"
] | null | [
"deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity",
"DNA nucleotidyltransferase (RNA-directed) activity",
"reverse transcriptase activity",
"revertase activity",
"RNA revertase activity",
"RNA-dependent deoxyribonucleate nucleotidyltransferase activity",
"RNA-dependen... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.49",
"MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN",
"Reactome:R-HSA-164504 \"Synthesis of minus strand strong stop DNA (-sssDNA)\"",
"Reactome:R-HSA-164520 \"Minus strand DNA synthesis resumes\""
] | [
"GO:0034061"
] | [
"part_of GO:0006278"
] | [
"part_of"
] | [
"GO:0006278"
] | [
"GO:0006278",
"GO:0034061"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.49",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28394\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28442\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0003966 | 3,966 | obsolete RNA-directed DNA polymerase, transposon encoded | molecular_function | OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. | [
"EC:2.7.7.49"
] | This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. | [
"RNA-directed DNA polymerase, transposon encoded"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003964"
] | [] | [] | null | null | true | true | 7 |
GO:0003967 | 3,967 | obsolete RNA-directed DNA polymerase, group II intron encoded | molecular_function | OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. | [
"EC:2.7.7.49"
] | This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. | [
"RNA-directed DNA polymerase, group II intron encoded"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0003964"
] | [] | [] | null | null | true | true | 1 |
GO:0003968 | 3,968 | RNA-directed RNA polymerase activity | molecular_function | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. | [
"EC:2.7.7.48",
"GOC:mah",
"GOC:pf"
] | null | [
"RdRP activity",
"RNA nucleotidyltransferase (RNA-directed) activity",
"RNA replicase activity",
"RNA synthetase activity",
"RNA-dependent RNA polymerase activity",
"RNA-dependent RNA replicase activity",
"RNA-directed 5'-3' RNA polymerase activity",
"transcriptase"
] | [
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"BROAD"
] | [] | [] | [
"EC:2.7.7.48",
"MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN",
"Reactome:R-HSA-168280 \"Priming and Initiation of Transcription\"",
"Reactome:R-HSA-168301 \"Elongation, Polyadenylation and Termination\"",
"Reactome:R-HSA-192624 \"cRNA Extension\"",
"Reactome:R-HSA-192832 \"Initiation of cRNA Synthesis\"",
"R... | [
"GO:0034062"
] | [
"part_of GO:0001172"
] | [
"part_of"
] | [
"GO:0001172"
] | [
"GO:0001172",
"GO:0034062"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.48",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23750\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003969 | 3,969 | obsolete RNA editase activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it describes a biological process. | [
"RNA editase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 1 |
GO:0003972 | 3,972 | RNA ligase (ATP) activity | molecular_function | Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate. | [
"EC:6.5.1.3"
] | null | [
"poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)",
"polyribonucleotide ligase activity",
"polyribonucleotide synthase (ATP) activity",
"ribonucleic ligase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:6.5.1.3",
"MetaCyc:RNA-LIGASE-ATP-RXN",
"Reactome:R-HSA-5696816 \"tRNA ligase complex ligates tRNA exons\""
] | [
"GO:0008452"
] | [] | [] | [] | [
"GO:0008452"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.5.1.3",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27418\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003973 | 3,973 | (S)-2-hydroxy-acid oxidase activity | molecular_function | Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2. | [
"RHEA:16789"
] | null | [
"glycolate oxidase activity",
"hydroxy-acid oxidase A activity",
"hydroxy-acid oxidase B activity",
"hydroxyacid oxidase A",
"L-2-hydroxy acid oxidase",
"L-alpha-hydroxy acid oxidase",
"long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity",
"medium-chain-(S)-2-hydroxy-acid oxidase activity",
"v... | [
"RELATED",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0008891",
"GO:0052852",
"GO:0052853",
"GO:0052854"
] | [] | [
"EC:1.1.3.15",
"MetaCyc:RXN-969",
"MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN",
"Reactome:R-HSA-389842 \"HAO1 tetramer oxidizes glycolate to glyoxylate\"",
"Reactome:R-HSA-6787811 \"HAO2 tetramer oxidises 2OH-PALM\"",
"RHEA:16789",
"RHEA:27662",
"RHEA:41227"
] | [
"GO:0016899"
] | [] | [] | [] | [
"GO:0016899"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.3.15",
"skos:exactMatch MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN",
"skos:exactMatch RHEA:16789",
"skos:narrowMatch MetaCyc:RXN-969",
"skos:narrowMatch RHEA:27662",
"skos:narrowMatch RHEA:41227",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21795\" xsd:anyUR... | null | null | false | true | 2 |
GO:0003974 | 3,974 | UDP-N-acetylglucosamine 4-epimerase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. | [
"EC:5.1.3.7"
] | null | [
"UDP acetylglucosamine epimerase activity",
"UDP-GlcNAc 4-epimerase activity",
"UDP-N-acetyl-D-glucosamine 4-epimerase activity",
"uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity",
"uridine diphosphate N-acetylglucosamine-4-epimerase activity",
"uridine diphosphoacetylglucosamine epimerase a... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.1.3.7",
"MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN",
"RHEA:20517"
] | [
"GO:0016857"
] | [] | [] | [] | [
"GO:0016857"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.1.3.7",
"skos:exactMatch RHEA:20517",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 9 |
GO:0003976 | 3,976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | molecular_function | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. | [
"EC:2.7.8.17"
] | null | [
"lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity",
"N-acetylglucosaminyl phosphotransferase activity",
"N-acetylglucosaminylphosphotransferase activity",
"UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity",
"UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-ace... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.8.17",
"MetaCyc:2.7.8.17-RXN",
"RHEA:13581"
] | [
"GO:0016780"
] | [] | [] | [] | [
"GO:0016780"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.8.17",
"skos:exactMatch RHEA:13581",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003977 | 3,977 | UDP-N-acetylglucosamine diphosphorylase activity | molecular_function | Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. | [
"EC:2.7.7.23",
"RHEA:13509"
] | null | [
"acetylglucosamine 1-phosphate uridylyltransferase",
"GlmU uridylyltransferase activity",
"N-acetylglucosamine-1-phosphate uridyltransferase activity",
"UDP-acetylglucosamine pyrophosphorylase activity",
"UDP-GlcNAc pyrophosphorylase activity",
"UDP-N-acetylglucosamine pyrophosphorylase activity",
"urid... | [
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.23",
"KEGG_REACTION:R00416",
"MetaCyc:NAG1P-URIDYLTRANS-RXN",
"Reactome:R-HSA-446204 \"GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine\"",
"RHEA:13509"
] | [
"GO:0070569"
] | [] | [] | [] | [
"GO:0070569"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.23",
"skos:exactMatch RHEA:13509",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003978 | 3,978 | UDP-glucose 4-epimerase activity | molecular_function | Catalysis of the reaction: UDP-glucose = UDP-galactose. | [
"EC:5.1.3.2"
] | null | [
"4-epimerase activity",
"galactowaldenase activity",
"UDP-D-galactose 4-epimerase activity",
"UDP-galactose 4-epimerase activity",
"UDP-glucose epimerase activity",
"UDPG-4-epimerase activity",
"UDPgalactose 4-epimerase activity",
"UDPglucose 4-epimerase activity",
"uridine diphosphate galactose 4-e... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.1.3.2",
"MetaCyc:UDPGLUCEPIM-RXN",
"Reactome:R-HSA-5610036 \"Defective GALE does not epimerise UDP-Gal to UDP-Glc\"",
"Reactome:R-HSA-70369 \"GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc\"",
"RHEA:22168"
] | [
"GO:0016857"
] | [] | [] | [] | [
"GO:0016857"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.1.3.2",
"skos:exactMatch RHEA:22168",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003979 | 3,979 | UDP-glucose 6-dehydrogenase activity | molecular_function | Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate. | [
"EC:1.1.1.22",
"RHEA:23596"
] | null | [] | [] | [] | [] | [
"EC:1.1.1.22",
"KEGG_REACTION:R00286",
"MetaCyc:UGD-RXN",
"Reactome:R-HSA-173597 \"UDP-glucose is oxidised to UDP-glucuronate\"",
"RHEA:23596"
] | [
"GO:0016616"
] | [] | [] | [] | [
"GO:0016616"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.22",
"skos:exactMatch RHEA:23596",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003980 | 3,980 | UDP-glucose:glycoprotein glucosyltransferase activity | molecular_function | Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. | [
"GOC:al",
"PMID:10764828"
] | null | [
"UGGT activity"
] | [
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-548884 \"UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b\"",
"RHEA:61304"
] | [
"GO:0035251"
] | [
"part_of GO:0097359"
] | [
"part_of"
] | [
"GO:0097359"
] | [
"GO:0035251",
"GO:0097359"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch RHEA:61304",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25719\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003983 | 3,983 | UTP:glucose-1-phosphate uridylyltransferase activity | molecular_function | Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. | [
"EC:2.7.7.9",
"RHEA:19889"
] | null | [
"glucose-1-phosphate uridylyltransferase activity",
"UDP glucose pyrophosphorylase activity",
"UDP-glucose diphosphorylase activity",
"UDP-glucose pyrophosphorylase activity",
"UDPG phosphorylase activity",
"UDPG pyrophosphorylase activity",
"uridine 5'-diphosphoglucose pyrophosphorylase activity",
"u... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.7.9",
"KEGG_REACTION:R00289",
"MetaCyc:GLUC1PURIDYLTRANS-RXN",
"Reactome:R-HSA-70286 \"UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose\"",
"RHEA:19889"
] | [
"GO:0051748"
] | [] | [] | [] | [
"GO:0051748"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.7.9",
"skos:exactMatch RHEA:19889",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003984 | 3,984 | acetolactate synthase activity | molecular_function | Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. | [
"EC:2.2.1.6"
] | null | [
"acetohydroxy acid synthetase activity",
"acetohydroxyacid synthase activity",
"acetolactate pyruvate-lyase (carboxylating) activity",
"acetolactic synthetase activity",
"alpha-acetohydroxy acid synthetase activity",
"alpha-acetohydroxyacid synthase activity",
"alpha-acetolactate synthase activity",
"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.2.1.6",
"MetaCyc:ACETOLACTSYN-RXN",
"RHEA:25249",
"RHEA:27654"
] | [
"GO:0016744"
] | [] | [] | [] | [
"GO:0016744"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.2.1.6",
"skos:narrowMatch RHEA:25249",
"skos:narrowMatch RHEA:27654",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28613\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28938\" xsd:anyURI",
"term_tracker_item \"https:/... | null | null | false | true | 5 |
GO:0003985 | 3,985 | acetyl-CoA C-acetyltransferase activity | molecular_function | Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. | [
"RHEA:21036"
] | null | [
"acetoacetyl-CoA thiolase activity",
"acetyl coenzyme A thiolase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.9",
"MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN",
"Reactome:R-HSA-70844 \"alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA\"",
"Reactome:R-HSA-73916 \"2 acetyl-CoA <=> acetoacetyl-CoA + CoA\"",
"Reactome:R-HSA-74181 \"acetoacetyl-CoA + CoA <=> 2 acetyl-CoA\"",
"Reactome:R-HSA-8848215 \... | [
"GO:0003988",
"GO:0016453"
] | [] | [] | [] | [
"GO:0003988",
"GO:0016453"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.9",
"skos:exactMatch RHEA:21036",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003986 | 3,986 | acetyl-CoA hydrolase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + H2O = acetate + CoA + H+. | [
"EC:3.1.2.1",
"RHEA:20289"
] | null | [
"acetyl coenzyme A acylase activity",
"acetyl coenzyme A deacylase activity",
"acetyl coenzyme A hydrolase activity",
"acetyl-CoA acylase activity",
"acetyl-CoA deacylase activity",
"acetyl-CoA thiol esterase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.2.1",
"KEGG_REACTION:R00227",
"MetaCyc:ACETYL-COA-HYDROLASE-RXN",
"Reactome:R-HSA-2066779 \"Conversion of DHA-CoA to docosahexaenoic acid (DHA)\"",
"Reactome:R-HSA-390304 \"acetyl-CoA + H2O => acetate + CoASH + H+\"",
"RHEA:20289"
] | [
"GO:0016289"
] | [] | [] | [] | [
"GO:0016289"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.2.1",
"skos:exactMatch RHEA:20289",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003987 | 3,987 | acetyl-CoA synthetase activity | molecular_function | Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate. | [
"RHEA:23176"
] | null | [
"acetate thiokinase activity",
"acetate to acetyl-CoA",
"acetate-CoA ligase activity",
"acetate:CoA ligase (AMP-forming)",
"acetic thiokinase activity",
"acetyl activating enzyme",
"acetyl CoA ligase activity",
"acetyl CoA synthase activity",
"acetyl coenzyme A synthetase activity",
"acetyl-activa... | [
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.2.1.1",
"MetaCyc:ACETATE--COA-LIGASE-RXN",
"Reactome:R-HSA-449911 \"acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]\"",
"Reactome:R-HSA-71735 \"acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]\"",
"Reactome:R-HSA-8875071 \"ACSS3 ligates CoA to CH3COO-\"",
"... | [
"GO:0016405"
] | [] | [] | [] | [
"GO:0016405"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.2.1.1",
"skos:exactMatch RHEA:23176",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0003988 | 3,988 | acetyl-CoA C-acyltransferase activity | molecular_function | Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. | [
"RHEA:21564"
] | null | [
"2-keto-acyl thiolase activity",
"3-ketoacyl coenzyme A thiolase activity",
"3-ketoacyl-CoA thiolase activity",
"3-ketothiolase activity",
"acetoacetyl-CoA beta-ketothiolase activity",
"acetyl-CoA acyltransferase activity",
"beta-ketoacyl coenzyme A thiolase activity",
"beta-ketothiolase activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"EC:2.3.1.16",
"MetaCyc:KETOACYLCOATHIOL-RXN",
"Reactome:R-HSA-390250 \"3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA\"",
"Reactome:R-HSA-77271 \"3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA\"",
"Reactome:R-HSA-77304 \"3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA\"",
"Reactome:R-HSA-77309 \... | [
"GO:0016408"
] | [] | [] | [] | [
"GO:0016408"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.16",
"skos:exactMatch RHEA:21564",
"skos:narrowMatch RHEA:34799",
"skos:narrowMatch RHEA:46312",
"skos:narrowMatch RHEA:67224",
"skos:narrowMatch RHEA:78895",
"skos:narrowMatch RHEA:78899",
"skos:narrowMatch RHEA:78903",
"skos:narrowMatch RHEA:78907",
"term_tracker_item \... | null | null | false | true | 7 |
GO:0003989 | 3,989 | acetyl-CoA carboxylase activity | molecular_function | Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. | [
"EC:6.4.1.2"
] | null | [
"acetyl coenzyme A carboxylase activity",
"acetyl-CoA:carbon-dioxide ligase (ADP-forming)"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.4.1.2",
"MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN",
"Reactome:R-HSA-200555 \"Formation of Malonyl-CoA from Acetyl-CoA (liver)\"",
"Reactome:R-HSA-75851 \"Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA\"",
"Reactome:R-HSA-8876889 \"Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA... | [
"GO:0016421"
] | [] | [] | [] | [
"GO:0016421"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.4.1.2",
"skos:exactMatch RHEA:11308",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0003990 | 3,990 | acetylcholinesterase activity | molecular_function | Catalysis of the reaction: acetylcholine + H2O = choline + acetate. | [
"EC:3.1.1.7"
] | null | [
"AcCholE",
"acetyl.beta-methylcholinesterase activity",
"acetylcholine acetylhydrolase activity",
"acetylcholine hydrolase activity",
"acetylthiocholinesterase activity",
"choline esterase I activity",
"true cholinesterase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.1.1.7",
"MetaCyc:ACETYLCHOLINESTERASE-RXN",
"Reactome:R-HSA-372519 \"AcCho is hydrolyzed to Cho and acetate by ACHE\"",
"RHEA:17561"
] | [
"GO:0004104"
] | [] | [] | [] | [
"GO:0004104"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.7",
"skos:exactMatch RHEA:17561",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0003991 | 3,991 | acetylglutamate kinase activity | molecular_function | Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. | [
"EC:2.7.2.8"
] | null | [
"acetylglutamate phosphokinase activity",
"ATP:N-acetyl-L-glutamate 5-phosphotransferase activity",
"N-acetylglutamate 5-phosphotransferase activity",
"N-acetylglutamate kinase activity",
"N-acetylglutamate phosphokinase activity",
"N-acetylglutamic 5-phosphotransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.2.8",
"MetaCyc:ACETYLGLUTKIN-RXN",
"RHEA:14629"
] | [
"GO:0016301",
"GO:0016774"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016774"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.2.8",
"skos:exactMatch RHEA:14629",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0003993 | 3,993 | acid phosphatase activity | molecular_function | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. | [
"EC:3.1.3.2"
] | null | [
"acid monophosphatase activity",
"acid nucleoside diphosphate phosphatase activity",
"acid phosphohydrolase activity",
"acid phosphomonoester hydrolase activity",
"acid phosphomonoesterase activity",
"glycerophosphatase activity",
"orthophosphoric-monoester phosphohydrolase (acid optimum)",
"phosphate... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:3.1.3.2",
"MetaCyc:ACID-PHOSPHATASE-RXN",
"Reactome:R-HSA-196950 \"2xTRAP hydrolyzes FMN to RIB\""
] | [
"GO:0016791"
] | [] | [] | [] | [
"GO:0016791"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch RHEA:15017",
"skos:exactMatch EC:3.1.3.2",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0003994 | 3,994 | aconitate hydratase activity | molecular_function | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrat... | [
"EC:4.2.1.3",
"GOC:pde",
"GOC:vw"
] | null | [
"aconitase activity",
"cis-aconitase activity",
"citrate hydro-lyase activity",
"citrate(isocitrate) hydro-lyase (cis-aconitate-forming)",
"citrate(isocitrate) hydro-lyase activity"
] | [
"EXACT",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [
"GO:0052632"
] | [] | [
"EC:4.2.1.3",
"MetaCyc:RXN-14047",
"Reactome:R-HSA-5690911 \"ACO1:4Fe-4S isomerises CIT to ISCIT\"",
"Reactome:R-HSA-70971 \"ACO2 isomerizes citrate\"",
"RHEA:10336"
] | [
"GO:0016836"
] | [] | [] | [] | [
"GO:0016836"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.2.1.3",
"skos:exactMatch RHEA:10336",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0003995 | 3,995 | acyl-CoA dehydrogenase activity | molecular_function | Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. | [
"RHEA:44704"
] | null | [
"acyl CoA dehydrogenase activity",
"acyl coenzyme A dehydrogenase activity",
"acyl-CoA reductase activity",
"fatty acyl coenzyme A dehydrogenase activity",
"fatty-acyl-CoA dehydrogenase activity",
"general acyl CoA dehydrogenase activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [
"GO:0019109"
] | [] | [
"MetaCyc:ACYLCOADEHYDROG-RXN",
"Reactome:R-HSA-109341 \"dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA\"",
"Reactome:R-HSA-5695980 \"ACAD10 dehydrogenates S-2MPDA-CoA\"",
"Reactome:R-HSA-5695989 \"ACAD11 dehydrogenates BH-CoA\"",
"Reactome:R-HSA-70800 \"alpha-methylbutyryl-CoA +... | [
"GO:0052890"
] | [] | [] | [] | [
"GO:0052890"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch MetaCyc:ACYLCOADEHYDROG-RXN",
"skos:exactMatch RHEA:44704",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23497\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25801\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneo... | null | null | false | true | 7 |
GO:0003998 | 3,998 | acylphosphatase activity | molecular_function | Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. | [
"EC:3.6.1.7"
] | null | [
"1,3-diphosphoglycerate phosphatase activity",
"acetic phosphatase activity",
"acetylphosphatase activity",
"acylphosphate phosphohydrolase activity",
"GP 1-3",
"Ho 1-3"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.6.1.7",
"MetaCyc:ACYLPHOSPHATASE-RXN",
"RHEA:14965"
] | [
"GO:0016462"
] | [] | [] | [] | [
"GO:0016462"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.7",
"skos:exactMatch RHEA:14965",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23401\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0003999 | 3,999 | adenine phosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. | [
"RHEA:16609"
] | null | [
"adenine phosphoribosylpyrophosphate transferase activity",
"adenosine phosphoribosyltransferase activity",
"adenylate pyrophosphorylase activity",
"adenylic pyrophosphorylase activity",
"AMP diphosphorylase activity",
"AMP pyrophosphorylase activity",
"AMP-pyrophosphate phosphoribosyltransferase activi... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.7",
"MetaCyc:ADENPRIBOSYLTRAN-RXN",
"Reactome:R-HSA-74213 \"APRT catalyzes the conversion of adenine to AMP\"",
"Reactome:R-HSA-9734193 \"Defective APRT does not convert adenine to AMP\"",
"RHEA:16609"
] | [
"GO:0106130"
] | [] | [] | [] | [
"GO:0106130"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.7",
"skos:exactMatch RHEA:16609"
] | null | null | false | true | 7 |
GO:0004000 | 4,000 | adenosine deaminase activity | molecular_function | Catalysis of the reaction: adenosine + H2O = inosine + NH4+. | [
"RHEA:24408"
] | null | [
"adenosine aminohydrolase activity",
"adenosine deaminase reaction"
] | [
"RELATED",
"EXACT"
] | [] | [] | [
"MetaCyc:ADENODEAMIN-RXN",
"Reactome:R-HSA-5693346 \"CECRI deaminates Ade-Rib to Ino\"",
"RHEA:24408"
] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [
"GO:0016814",
"GO:0019239"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:3.5.4.4",
"skos:exactMatch RHEA:24408"
] | null | null | false | true | 8 |
GO:0004005 | 4,005 | obsolete plasma membrane cation-transporting ATPase | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:ai"
] | This term was made obsolete because it contains both component and function information. | [
"plasma membrane cation-transporting ATPase"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005886",
"GO:0019829"
] | [] | null | null | true | true | 2 |
GO:0004007 | 4,007 | obsolete heavy metal-exporting ATPase activity | molecular_function | OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate. | [
"GOC:ai"
] | This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). | [
"heavy metal-exporting ATPase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0046873"
] | [] | null | null | true | true | 1 |
GO:0004009 | 4,009 | obsolete ATP-binding cassette (ABC) transporter activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. | [
"ATP-binding cassette (ABC) transporter activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0042626",
"GO:0043190"
] | [] | null | null | true | true | 9 |
GO:0004013 | 4,013 | adenosylhomocysteinase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. | [
"RHEA:21708"
] | null | [
"adenosylhomocysteine hydrolase activity",
"AdoHcyase activity",
"S-adenosyl-L-homocysteine hydrolase activity",
"S-adenosylhomocysteinase activity",
"S-adenosylhomocysteine hydrolase activity",
"S-adenosylhomocysteine synthase activity",
"SAHase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:3.13.2.1",
"MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN",
"Reactome:R-HSA-174401 \"AHCY:NAD+ tetramer hydrolyses AdoHcy\"",
"Reactome:R-HSA-5579084 \"Defective AHCY does not hydrolyse AdoHcy\"",
"RHEA:21708"
] | [
"GO:0046508"
] | [] | [] | [] | [
"GO:0046508"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.13.2.1",
"skos:exactMatch RHEA:21708",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24053\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004014 | 4,014 | adenosylmethionine decarboxylase activity | molecular_function | Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. | [
"EC:4.1.1.50",
"RHEA:15981"
] | null | [
"adenosyl methionine decarboxylase activity",
"S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]",
"S-adenosyl-L-methionine carboxy-lyase activity",
"S-adenosyl-L-methionine decarboxylase activity",
"S-adenosylmethionine decarboxylase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.50",
"KEGG_REACTION:R00178",
"MetaCyc:SAMDECARB-RXN",
"Reactome:R-HSA-351222 \"S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2\"",
"RHEA:15981"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.50",
"skos:exactMatch RHEA:15981",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004015 | 4,015 | S-adenosyl-L-methionine:8-amino-7-oxononanoate transaminase activity | molecular_function | Catalysis of the reaction: (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate. | [
"RHEA:16861"
] | null | [
"7,8-diamino-pelargonic acid aminotransferase activity",
"7,8-diaminonanoate transaminase activity",
"7,8-diaminononanoate aminotransferase activity",
"7,8-diaminononanoate transaminase activity",
"7,8-diaminopelargonic acid aminotransferase activity",
"7-keto-8-aminopelargonic acid",
"7-keto-8-aminopel... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.62",
"KEGG_REACTION:R03231",
"MetaCyc:DAPASYN-RXN",
"RHEA:16861"
] | [
"GO:0008483"
] | [] | [] | [] | [
"GO:0008483"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.62",
"skos:exactMatch RHEA:16861",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31140\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004017 | 4,017 | AMP kinase activity | molecular_function | Catalysis of the reaction: ATP + AMP = 2 ADP. | [
"RHEA:12973"
] | null | [
"5'-AMP-kinase activity",
"adenylate kinase activity",
"adenylic kinase activity",
"adenylokinase activity",
"ATP:AMP phosphotransferase activity",
"myokinase activity"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:2.7.4.3",
"MetaCyc:ADENYL-KIN-RXN",
"Reactome:R-HSA-110141 \"(d)ADP + ADP <=> (d)AMP + ATP (AK1)\"",
"Reactome:R-HSA-110144 \"ADP + ADP <=> AMP + ATP [AK2]\"",
"Reactome:R-HSA-110145 \"AMP + ATP <=> ADP + ADP [AK2]\"",
"Reactome:R-HSA-74220 \"(d)AMP + ATP <=> (d)ADP + ADP (AK1)\"",
"RHEA:12973"
] | [
"GO:0050145"
] | [] | [] | [] | [
"GO:0050145"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.4.3",
"skos:exactMatch MetaCyc:ADENYL-KIN-RXN",
"skos:exactMatch RHEA:12973",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27917\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29533\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004018 | 4,018 | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | molecular_function | Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. | [
"RHEA:16853"
] | null | [
"6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity",
"adenylosuccinase activity",
"adenylosuccinate lyase activity",
"N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity",
"succino AMP-lyase activity"
] | [
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"BROAD"
] | [] | [] | [
"KEGG_REACTION:R01083",
"MetaCyc:AMPSYN-RXN",
"RHEA:16853"
] | [
"GO:0016842"
] | [] | [] | [] | [
"GO:0016842"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:4.3.2.2",
"skos:exactMatch RHEA:16853"
] | null | null | false | true | 6 |
GO:0004019 | 4,019 | adenylosuccinate synthase activity | molecular_function | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate. | [
"EC:6.3.4.4",
"RHEA:15753"
] | null | [
"adenylosuccinate synthetase activity",
"IMP--aspartate ligase activity",
"IMP:L-aspartate ligase (GDP-forming)",
"succino-AMP synthetase activity",
"succinoadenylic kinosynthetase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.4",
"KEGG_REACTION:R01135",
"MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN",
"Reactome:R-HSA-111524 \"IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]\"",
"RHEA:15753"
] | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.4",
"skos:exactMatch RHEA:15753",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004020 | 4,020 | adenylylsulfate kinase activity | molecular_function | Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+. | [
"EC:2.7.1.25"
] | null | [
"5'-phosphoadenosine sulfate kinase activity",
"adenosine 5'-phosphosulfate kinase activity",
"adenosine phosphosulfate kinase activity",
"adenosine phosphosulfokinase activity",
"adenosine-5'-phosphosulfate 3'-phosphotransferase activity",
"adenosine-5'-phosphosulfate-3'-phosphokinase activity",
"adeno... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.1.25",
"MetaCyc:ADENYLYLSULFKIN-RXN",
"Reactome:R-HSA-174389 \"PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS\"",
"Reactome:R-HSA-3560785 \"Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS\"",
"RHEA:24152"
] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [
"GO:0016301",
"GO:0016773"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.1.25",
"skos:exactMatch RHEA:24152",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28907\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004021 | 4,021 | L-alanine:2-oxoglutarate transaminase activity | molecular_function | Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate. | [
"RHEA:19453"
] | null | [
"alanine aminotransferase activity",
"alanine transaminase activity",
"alanine-alpha-ketoglutarate aminotransferase activity",
"alanine-pyruvate aminotransferase activity",
"ALT",
"beta-alanine aminotransferase",
"glutamic acid-pyruvic acid transaminase activity",
"glutamic--alanine transaminase activ... | [
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"EXACT",
"BROAD",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.6.1.2",
"KEGG_REACTION:R00258",
"MetaCyc:ALANINE-AMINOTRANSFERASE-RXN",
"Reactome:R-HSA-507749 \"PXLP-K341-GPT2 transaminates PYR to form L-Ala\"",
"Reactome:R-HSA-507775 \"PXLP-K341-GPT2 transaminates L-Ala to form PYR\"",
"Reactome:R-HSA-70523 \"PXLP-K314-GPT transaminates L-Ala to form PYR\"",
... | [
"GO:0047635"
] | [] | [] | [] | [
"GO:0047635"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.2",
"skos:exactMatch KEGG_REACTION:R00258",
"skos:exactMatch MetaCyc:ALANINE-AMINOTRANSFERASE-RXN",
"skos:exactMatch RHEA:19453",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-o... | null | null | false | true | 9 |
GO:0004022 | 4,022 | alcohol dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. | [
"EC:1.1.1.1"
] | null | [
"ADH",
"alcohol dehydrogenase activity",
"alcohol:NAD+ oxidoreductase",
"aldehyde dehydrogenase (NAD) activity",
"aldo-keto reductase (NAD) activity",
"aliphatic alcohol dehydrogenase",
"ethanol dehydrogenase",
"NAD-dependent alcohol dehydrogenase",
"NAD-specific aromatic alcohol dehydrogenase",
"... | [
"RELATED",
"BROAD",
"RELATED",
"NARROW",
"EXACT",
"NARROW",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"NARROW"
] | [] | [] | [
"EC:1.1.1.1",
"MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN",
"MetaCyc:RXN-12448",
"Reactome:R-HSA-2162078 \"abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+\"",
"Reactome:R-HSA-71707 \"ethanol + NAD+ => acetaldehyde + NADH + H+\"",
"RHEA:10736",
"RHEA:10740"
] | [
"GO:0018455"
] | [] | [] | [] | [
"GO:0018455"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.1.1.1",
"skos:narrowMatch MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN",
"skos:narrowMatch MetaCyc:RXN-12448",
"skos:narrowMatch RHEA:10736",
"skos:narrowMatch RHEA:10740",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28532\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004023 | 4,023 | obsolete alcohol dehydrogenase (NAD+) activity, metal ion-independent | molecular_function | OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion. | [
"GOC:mah"
] | This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022. | [
"alcohol dehydrogenase activity, metal ion-independent"
] | [
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004022"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28393\" xsd:anyURI"
] | null | null | true | true | 1 |
GO:0004024 | 4,024 | obsolete alcohol dehydrogenase (NAD+) activity, zinc-dependent | molecular_function | OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. | [
"GOC:mah"
] | This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022. | [
"alcohol dehydrogenase activity, zinc-dependent"
] | [
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004022"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28393\" xsd:anyURI"
] | null | null | true | true | 1 |
GO:0004025 | 4,025 | obsolete alcohol dehydrogenase (NAD+) activity, iron-dependent | molecular_function | OBSOLETE. Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron. | [
"GOC:mah"
] | This term was obsoleted because it represents the same activity as alcohol dehydrogenase (NAD+) activity ; GO:0004022. | [
"alcohol dehydrogenase activity, iron-dependent"
] | [
"BROAD"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004022"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28393\" xsd:anyURI"
] | null | null | true | true | 3 |
GO:0004027 | 4,027 | alcohol sulfotransferase activity | molecular_function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. | [
"EC:2.8.2.2"
] | null | [
"3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity",
"3-hydroxysteroid sulfotransferase activity",
"3beta-hydroxy steroid sulfotransferase activity",
"3beta-hydroxysteroid sulfotransferase activity",
"5alpha-androstenol sulfotransferase activity",
"alcohol sulphotransferase activity",
"alcoho... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:2.8.2.2",
"MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN",
"Reactome:R-HSA-176494 \"SULTs transfer (SO4)2- group to 27HCHOL\"",
"Reactome:R-HSA-176609 \"cholesterol + PAPS => cholesterol sulfate + PAP\"",
"RHEA:22552",
"RHEA:59300",
"RHEA:59304"
] | [
"GO:0008146"
] | [] | [] | [] | [
"GO:0008146"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.8.2.2",
"skos:exactMatch RHEA:22552",
"skos:narrowMatch RHEA:59300",
"skos:narrowMatch RHEA:59304",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004028 | 4,028 | 3-chloroallyl aldehyde dehydrogenase activity | molecular_function | Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28261\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004029 | 4,029 | aldehyde dehydrogenase (NAD+) activity | molecular_function | Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH. | [
"RHEA:16185"
] | null | [
"aldehyde dehydrogenase (NAD+)",
"aldehyde:NAD+ oxidoreductase activity",
"CoA-independent aldehyde dehydrogenase activity",
"m-methylbenzaldehyde dehydrogenase activity",
"NAD-aldehyde dehydrogenase activity",
"NAD-dependent 4-hydroxynonenal dehydrogenase activity",
"NAD-dependent aldehyde dehydrogenas... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.1.3",
"MetaCyc:ALDHDEHYDROG-RXN",
"Reactome:R-HSA-380608 \"5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid\"",
"Reactome:R-HSA-389609 \"ALDH3A2-2 oxidizes pristanal to pristanate\"",
"Reactome:R-HSA-5692261 \"ALDH3A2-1 oxidises HD2NAL to PALM\"",
"Reactome:R-HSA-5696091 \"ALDH1B1 tetra... | [
"GO:0004030"
] | [] | [] | [] | [
"GO:0004030"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.3",
"skos:exactMatch RHEA:16185",
"skos:narrowMatch RHEA:30867",
"skos:narrowMatch RHEA:30879",
"skos:narrowMatch RHEA:31043",
"skos:narrowMatch RHEA:31059",
"skos:narrowMatch RHEA:31215",
"skos:narrowMatch RHEA:31231",
"skos:narrowMatch RHEA:31243",
"skos:narrowMatch RHE... | null | null | false | true | 9 |
GO:0004030 | 4,030 | aldehyde dehydrogenase [NAD(P)+] activity | molecular_function | Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. | [
"EC:1.2.1.5"
] | null | [
"aldehyde:NAD(P)+ oxidoreductase activity",
"ALDH"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.1.5",
"MetaCyc:ALDEHYDE-DEHYDROGENASE-NADORNOP+-RXN",
"Reactome:R-HSA-5692283 \"ALD3A1 oxidises 4HPCP to CXPA\"",
"Reactome:R-HSA-5696080 \"ALDH3B1 oxidises HXAL to PALM\"",
"Reactome:R-HSA-6808464 \"ALDH3B2 oxidises HXAL to PALM\""
] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.5",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28183\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29544\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004031 | 4,031 | aldehyde oxidase activity | molecular_function | Catalysis of the reaction: an aldehyde + O2 + H2O = a carboxylate + H2O2 + H+. | [
"RHEA:16829"
] | null | [
"aldehyde:oxygen oxidoreductase activity",
"quinoline oxidase activity",
"retinal oxidase activity"
] | [
"RELATED",
"RELATED",
"NARROW"
] | [
"GO:0050250"
] | [] | [
"EC:1.2.3.1",
"MetaCyc:ALDEHYDE-OXIDASE-RXN",
"MetaCyc:RETINAL-OXIDASE-RXN",
"MetaCyc:RXN-8093",
"MetaCyc:RXN-8094",
"Reactome:R-HSA-3204311 \"AOX1 oxidises PXL to PDXate\"",
"RHEA:16829",
"RHEA:22520",
"RHEA:33439",
"RHEA:49636",
"RHEA:56736",
"RHEA:58964",
"RHEA:58976",
"RHEA:58980",
"... | [
"GO:0016623"
] | [] | [] | [] | [
"GO:0016623"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.3.1",
"skos:exactMatch MetaCyc:ALDEHYDE-OXIDASE-RXN",
"skos:exactMatch RHEA:16829",
"skos:narrowMatch MetaCyc:RETINAL-OXIDASE-RXN",
"skos:narrowMatch MetaCyc:RXN-8093",
"skos:narrowMatch MetaCyc:RXN-8094",
"skos:narrowMatch RHEA:22520",
"skos:narrowMatch RHEA:33439",
"skos:na... | null | null | false | true | 3 |
GO:0004032 | 4,032 | aldose reductase (NADPH) activity | molecular_function | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. | [
"EC:1.1.1.21"
] | null | [
"aldehyde reductase activity",
"alditol:NADP+ 1-oxidoreductase activity",
"aldose reductase activity",
"polyol dehydrogenase (NADP(+)) activity"
] | [
"RELATED",
"EXACT",
"RELATED",
"RELATED"
] | [] | [] | [
"KEGG_REACTION:R02820",
"Reactome:R-HSA-196060 \"Reduction of isocaproaldehyde to 4-methylpentan-1-ol\"",
"Reactome:R-HSA-5652172 \"AKR1B1 reduces Glc to D-sorbitol\"",
"Reactome:R-HSA-9931850 \"AKR1B1 reduces galactose to galactitol\"",
"RHEA:12789",
"RHEA:59924"
] | [
"GO:0008106"
] | [] | [] | [] | [
"GO:0008106"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.1.1.21",
"skos:broadMatch MetaCyc:ALDEHYDE-REDUCTASE-RXN",
"skos:exactMatch KEGG_REACTION:R02820",
"skos:exactMatch RHEA:12789",
"skos:narrowMatch RHEA:59924",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27136\" xsd:anyURI",
"term_tracker_item \"https://... | null | null | false | true | 1 |
GO:0004033 | 4,033 | obsolete aldo-keto reductase (NADPH) activity | molecular_function | OBSOLETE. Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. | [
"GOC:ai"
] | This term was obsoleted because it represents the same reaction as alcohol dehydrogenase (NADP+) activity ; GO:0008106. | [
"alcohol dehydrogenase (NADP+) activity",
"aldo-keto reductase (NADP) activity",
"aldo-keto reductase (NADP+) activity",
"aldo-keto reductase activity",
"NADPH-dependent aldo-keto reductase activity"
] | [
"NARROW",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0008106"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27180\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28532\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004034 | 4,034 | aldose 1-epimerase activity | molecular_function | Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. | [
"EC:5.1.3.3"
] | null | [
"aldose mutarotase activity",
"mutarotase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:5.1.3.3",
"MetaCyc:ALDOSE-1-EPIMERASE-RXN",
"Reactome:R-HSA-9931853 \"GALM converts beta-D-GAL to alpha-D-GAL\"",
"Reactome:R-HSA-9931926 \"Defective GALM doesn't convert beta-D-GAL to alpha-D-GAL\"",
"RHEA:10264",
"RHEA:28675",
"RHEA:63332",
"RHEA:63336"
] | [
"GO:0016857"
] | [] | [] | [] | [
"GO:0016857"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:5.1.3.3",
"skos:narrowMatch RHEA:10264",
"skos:narrowMatch RHEA:28675",
"skos:narrowMatch RHEA:63332",
"skos:narrowMatch RHEA:63336",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28011\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-o... | null | null | false | true | 5 |
GO:0004035 | 4,035 | alkaline phosphatase activity | molecular_function | Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. | [
"EC:3.1.3.1"
] | null | [
"alkaline phenyl phosphatase activity",
"alkaline phosphohydrolase activity",
"alkaline phosphomonoesterase activity",
"glycerophosphatase activity",
"orthophosphoric-monoester phosphohydrolase (alkaline optimum)",
"phosphate-monoester phosphohydrolase (alkaline optimum)",
"phosphomonoesterase activity"... | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"BROAD"
] | [] | [] | [
"EC:3.1.3.1",
"MetaCyc:ALKAPHOSPHA-RXN",
"Reactome:R-HSA-8878787 \"ALPI dimer hydrolyses phosphate monoesters\""
] | [
"GO:0016791"
] | [] | [] | [] | [
"GO:0016791"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch RHEA:15017",
"skos:exactMatch EC:3.1.3.1",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004037 | 4,037 | allantoicase activity | molecular_function | Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea. | [
"EC:3.5.3.4",
"RHEA:11016"
] | null | [
"allantoate amidinohydrolase activity",
"allantoine amidinohydrolase activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [
"EC:3.5.3.4",
"KEGG_REACTION:R02422",
"MetaCyc:ALLANTOICASE-RXN",
"RHEA:11016"
] | [
"GO:0016813"
] | [] | [] | [] | [
"GO:0016813"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.3.4",
"skos:exactMatch RHEA:11016",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004038 | 4,038 | allantoinase activity | molecular_function | Catalysis of the reaction: allantoin + H2O = allantoate. | [
"EC:3.5.2.5"
] | null | [
"(S)-allantoin amidohydrolase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:3.5.2.5",
"MetaCyc:ALLANTOINASE-RXN",
"RHEA:17029"
] | [
"GO:0016812"
] | [] | [] | [] | [
"GO:0016812"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.2.5",
"skos:exactMatch RHEA:17029",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 6 |
GO:0004039 | 4,039 | allophanate hydrolase activity | molecular_function | Catalysis of the reaction: H2O + 3 H+ + urea-1-carboxylate = 2 CO2 + 2 NH4. | [
"EC:3.5.1.54",
"RHEA:19029"
] | null | [
"allophanate lyase activity",
"urea-1-carboxylate amidohydrolase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.54",
"KEGG_REACTION:R00005",
"MetaCyc:ALLOPHANATE-HYDROLASE-RXN",
"RHEA:19029",
"UM-BBD_reactionID:r0848"
] | [
"GO:0016811"
] | [] | [] | [] | [
"GO:0016811"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.54",
"skos:exactMatch RHEA:19029",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004040 | 4,040 | amidase activity | molecular_function | Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+. | [
"RHEA:12020"
] | null | [
"acetamidase activity",
"acylamidase activity",
"acylamide amidohydrolase activity",
"acylase activity",
"amidohydrolase activity",
"fatty acylamidase activity",
"N-acetylaminohydrolase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.4",
"MetaCyc:AMIDASE-RXN",
"RHEA:12020",
"RHEA:34367",
"RHEA:34375",
"RHEA:35063",
"RHEA:45048",
"RHEA:64820",
"RHEA:64824",
"RHEA:68112",
"UM-BBD_reactionID:r0084",
"UM-BBD_reactionID:r0375",
"UM-BBD_reactionID:r1440"
] | [
"GO:0016811"
] | [] | [] | [] | [
"GO:0016811"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.4",
"skos:exactMatch RHEA:12020",
"skos:narrowMatch RHEA:34367",
"skos:narrowMatch RHEA:34375",
"skos:narrowMatch RHEA:35063",
"skos:narrowMatch RHEA:45048",
"skos:narrowMatch RHEA:64820",
"skos:narrowMatch RHEA:64824",
"skos:narrowMatch RHEA:68112",
"term_tracker_item \"... | null | null | false | true | 6 |
GO:0004042 | 4,042 | L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor | molecular_function | Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. | [
"RHEA:24292"
] | null | [
"acetyl-CoA:L-glutamate N-acetyltransferase activity",
"acetylglutamate acetylglutamate synthetase activity",
"AGAS",
"amino acid acetyltransferase activity",
"amino-acid N-acetyltransferase activity",
"L-glutamate N-acetyltransferase activity",
"N-acetylglutamate synthase activity"
] | [
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD"
] | [] | [] | [
"KEGG_REACTION:R00259",
"MetaCyc:N-ACETYLTRANSFER-RXN",
"Reactome:R-HSA-70542 \"glutamate + acetyl CoA => N-acetyl glutamate + CoA\"",
"Reactome:R-HSA-9955697 \"NAGS variants don't synthesize N-acetylglutamate\"",
"RHEA:24292"
] | [
"GO:0140085"
] | [] | [] | [] | [
"GO:0140085"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:2.3.1.1",
"skos:exactMatch RHEA:24292",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31438\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004043 | 4,043 | L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity | molecular_function | Catalysis of the reaction: (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + 2 H+. | [
"EC:1.2.1.31"
] | null | [
"2-aminoadipate semialdehyde dehydrogenase activity",
"2-aminoadipic semialdehyde dehydrogenase activity",
"AAR",
"alpha-aminoadipate reductase activity",
"alpha-aminoadipate-semialdehyde dehydrogenase activity",
"aminoadipate semialdehyde dehydrogenase activity",
"aminoadipate-semialdehyde dehydrogenas... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT"
] | [] | [] | [
"EC:1.2.1.31",
"MetaCyc:1.2.1.31-RXN",
"Reactome:R-HSA-70941 \"alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+\"",
"RHEA:12304",
"RHEA:12308"
] | [
"GO:0004030"
] | [] | [] | [] | [
"GO:0004030"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.31",
"skos:narrowMatch RHEA:12304",
"skos:narrowMatch RHEA:12308",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30732\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004044 | 4,044 | amidophosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. | [
"EC:2.4.2.14",
"RHEA:14905"
] | null | [
"5'-phosphoribosylpyrophosphate amidotransferase activity",
"5-phosphoribosyl-1-pyrophosphate amidotransferase activity",
"5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)",
"5-phosphororibosyl-1-pyrophosphate amidotransferase activity",
"alpha-5-phosphoribosyl-1-py... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.14",
"KEGG_REACTION:R01072",
"MetaCyc:PRPPAMIDOTRANS-RXN",
"Reactome:R-HSA-73815 \"5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate\"",
"RHEA:14905"
] | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.14",
"skos:exactMatch RHEA:14905",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004045 | 4,045 | peptidyl-tRNA hydrolase activity | molecular_function | Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+. | [
"RHEA:54448"
] | null | [
"aminoacyl-transfer ribonucleate hydrolase activity",
"aminoacyl-tRNA aminoacylhydrolase activity",
"aminoacyl-tRNA hydrolase reaction",
"D-tyrosyl-tRNA hydrolase activity",
"N-substituted aminoacyl transfer RNA hydrolase activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"NARROW",
"RELATED"
] | [
"GO:0019850",
"GO:0019851"
] | [] | [
"EC:3.1.1.29",
"MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN",
"Reactome:R-HSA-9937374 \"MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates\"",
"Reactome:R-HSA-9937719 \"ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide\"",
"RHEA:54448",
"RHEA:81979"
] | [
"GO:0052689",
"GO:0140101"
] | [] | [] | [] | [
"GO:0052689",
"GO:0140101"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.29",
"skos:exactMatch RHEA:54448",
"skos:narrowMatch RHEA:81979",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29746\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004046 | 4,046 | aminoacylase activity | molecular_function | Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. | [
"EC:3.5.1.14"
] | null | [
"acylase I activity",
"alpha-N-acylaminoacid hydrolase activity",
"amido acid deacylase activity",
"aminoacylase I activity",
"benzamidase activity",
"dehydropeptidase II activity",
"hippurase activity",
"histozyme activity",
"L-amino-acid acylase activity",
"L-aminoacylase activity",
"long acyl... | [
"NARROW",
"RELATED",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.14",
"MetaCyc:AMINOACYLASE-RXN",
"Reactome:R-HSA-5433074 \"ACY1:Zn2+ dimer hydrolyses mercapturic acids\"",
"Reactome:R-HSA-5579081 \"Defective ACY1 does not hydrolyse mercapturic acids\"",
"Reactome:R-HSA-9638046 \"ACY3:Zn2+ dimer hydrolyses mercapturic acids\"",
"Reactome:R-HSA-9753944 \"ACY1:... | [
"GO:0016811"
] | [] | [] | [] | [
"GO:0016811"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.14",
"skos:exactMatch RHEA:15565",
"skos:narrowMatch RHEA:36855",
"skos:narrowMatch RHEA:52628",
"skos:narrowMatch RHEA:54184",
"skos:narrowMatch RHEA:67368",
"skos:narrowMatch RHEA:67440",
"skos:narrowMatch RHEA:75515",
"skos:narrowMatch RHEA:81115",
"skos:narrowMatch RH... | null | null | false | true | 6 |
GO:0004047 | 4,047 | aminomethyltransferase activity | molecular_function | Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+. | [
"RHEA:16945"
] | null | [
"glycine synthase activity",
"glycine-cleavage system T-protein activity",
"protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity",
"protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity",
"S-amino... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.2.10",
"MetaCyc:GCVT-RXN",
"Reactome:R-HSA-5693977 \"AMT transfers NH2CH2 from GCSH:SAMDLL to THF\"",
"RHEA:16945"
] | [
"GO:0016742"
] | [] | [] | [] | [
"GO:0016742"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch EC:1.4.1.27",
"skos:broadMatch MetaCyc:GCVMULTI-RXN",
"skos:broadMatch RHEA:27758",
"skos:exactMatch EC:2.1.2.10",
"skos:exactMatch MetaCyc:GCVT-RXN",
"skos:exactMatch RHEA:16945",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23282\" xsd:anyURI",
"term_track... | null | null | false | true | 4 |
GO:0004048 | 4,048 | anthranilate phosphoribosyltransferase activity | molecular_function | Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. | [
"EC:2.4.2.18",
"RHEA:11768"
] | null | [
"anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity",
"anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity",
"anthranilate-PP-ribose-P phosphoribosyltransferase activity",
"N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase ac... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.4.2.18",
"KEGG_REACTION:R01073",
"MetaCyc:PRTRANS-RXN",
"RHEA:11768"
] | [
"GO:0016763"
] | [] | [] | [] | [
"GO:0016763"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.2.18",
"skos:exactMatch RHEA:11768",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004049 | 4,049 | anthranilate synthase activity | molecular_function | Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. | [
"EC:4.1.3.27"
] | null | [
"anthranilate synthetase activity",
"chorismate pyruvate-lyase (amino-accepting) activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.3.27",
"MetaCyc:ANTHRANSYN-RXN",
"RHEA:21732"
] | [
"GO:0016833"
] | [] | [] | [] | [
"GO:0016833"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.3.27",
"skos:exactMatch RHEA:21732",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004050 | 4,050 | apyrase activity | molecular_function | Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs... | [
"EC:3.6.1.5"
] | null | [] | [] | [] | [] | [
"EC:3.6.1.5",
"MetaCyc:RXN-14024",
"RHEA:20988",
"RHEA:36795",
"RHEA:64896",
"RHEA:64904",
"RHEA:64908",
"RHEA:77735"
] | [
"GO:0016462"
] | [] | [] | [] | [
"GO:0016462"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.6.1.5",
"skos:exactMatch RHEA:36795",
"skos:narrowMatch RHEA:20988",
"skos:narrowMatch RHEA:64896",
"skos:narrowMatch RHEA:64904",
"skos:narrowMatch RHEA:64908",
"skos:narrowMatch RHEA:77735",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/2473\" xsd:anyU... | null | null | false | true | 1 |
GO:0004051 | 4,051 | arachidonate 5-lipoxygenase activity | molecular_function | Catalysis of the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4. | [
"RHEA:32307"
] | Note that this is a multi-step reaction. | [
"5-delta-lipoxygenase activity",
"5-lipoxygenase activity",
"5Delta-lipoxygenase activity",
"arachidonate:oxygen 5-oxidoreductase activity",
"arachidonic 5-lipoxygenase activity",
"arachidonic acid 5-lipoxygenase activity",
"C-5-lipoxygenase activity",
"delta(5)-lipoxygenase activity",
"delta5-lipox... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"NARROW",
"RELATED",
"NARROW"
] | [] | [] | [
"EC:1.13.11.34",
"MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN",
"MetaCyc:RXN-8647",
"RHEA:17485",
"RHEA:17961",
"RHEA:32307"
] | [
"GO:0016702"
] | [] | [] | [] | [
"GO:0016702"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.13.11.34",
"skos:exactMatch RHEA:32307",
"skos:narrowMatch MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN",
"skos:narrowMatch MetaCyc:RXN-8647",
"skos:narrowMatch RHEA:17485",
"skos:narrowMatch RHEA:17961",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28199\" xs... | null | null | false | true | 4 |
GO:0004052 | 4,052 | arachidonate 12(S)-lipoxygenase activity | molecular_function | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. | [
"EC:1.13.11.31",
"RHEA:10428"
] | null | [
"12-lipoxygenase activity",
"12Delta-lipoxygenase activity",
"12S-lipoxygenase activity",
"arachidonate:oxygen 12-oxidoreductase activity",
"C-12 lipoxygenase activity",
"delta12-lipoxygenase activity",
"leukotriene A4 synthase",
"LTA4 synthase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED"
] | [] | [] | [
"EC:1.13.11.31",
"KEGG_REACTION:R01596",
"MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN",
"Reactome:R-HSA-2161948 \"Arachidonate is converted to 12-oxoETE by ALOX12\"",
"Reactome:R-HSA-2161950 \"Arachidonate is oxidised to 12R-HpETE by ALOX12B\"",
"Reactome:R-HSA-2161964 \"Arachidonate is oxidised to 12S-HpET... | [
"GO:0016702"
] | [] | [] | [] | [
"GO:0016702"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.13.11.31",
"skos:exactMatch RHEA:10428",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004053 | 4,053 | arginase activity | molecular_function | Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. | [
"EC:3.5.3.1"
] | null | [
"arginine amidinase activity",
"arginine transamidinase activity",
"canavanase activity",
"L-arginase activity",
"L-arginine amidinohydrolase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.3.1",
"MetaCyc:ARGINASE-RXN",
"Reactome:R-HSA-452036 \"arginine + H2O => ornithine + urea [ARG2]\"",
"Reactome:R-HSA-70569 \"arginine + H2O => ornithine + urea [ARG1]\"",
"Reactome:R-HSA-9956512 \"ARG1 variants don't synthesize urea and ornithine\"",
"RHEA:20569"
] | [
"GO:0016813"
] | [] | [] | [] | [
"GO:0016813"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.3.1",
"skos:exactMatch RHEA:20569",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004054 | 4,054 | arginine kinase activity | molecular_function | Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+. | [
"EC:2.7.3.3",
"RHEA:22940"
] | null | [
"adenosine 5'-triphosphate-arginine phosphotransferase activity",
"adenosine 5'-triphosphate:L-arginine",
"arginine phosphokinase activity",
"ATP:L-arginine N-phosphotransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.3.3",
"KEGG_REACTION:R00554",
"MetaCyc:ARGININE-KINASE-RXN",
"RHEA:22940"
] | [
"GO:0016775",
"GO:0019202"
] | [] | [] | [] | [
"GO:0016775",
"GO:0019202"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.3.3",
"skos:exactMatch RHEA:22940",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004055 | 4,055 | argininosuccinate synthase activity | molecular_function | Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. | [
"EC:6.3.4.5"
] | null | [
"arginine succinate synthetase activity",
"argininosuccinate synthetase activity",
"argininosuccinic acid synthetase activity",
"arginosuccinate synthetase activity",
"citrulline--aspartate ligase activity",
"L-citrulline:L-aspartate ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.5",
"MetaCyc:ARGSUCCINSYN-RXN",
"Reactome:R-HSA-70577 \"ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA\"",
"Reactome:R-HSA-9956517 \"ASS1 variants don't synthesize arginosuccinate\"",
"RHEA:10932"
] | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.5",
"skos:exactMatch RHEA:10932",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004056 | 4,056 | argininosuccinate lyase activity | molecular_function | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. | [
"EC:4.3.2.1"
] | null | [
"2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)",
"2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)",
"arginine-succinate lyase activity",
"argininosuccinic acid lyase activity",
"arginosuccinase activity",
"N-(L-argininosuccinate) arginine-lyase activity",
"omega-N-(L... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.3.2.1",
"MetaCyc:ARGSUCCINLYA-RXN",
"Reactome:R-HSA-70573 \"argininosuccinate <=> fumarate + arginine\"",
"Reactome:R-HSA-9956524 \"ASL variants don't synthesize fumarate and arginine\"",
"RHEA:24020"
] | [
"GO:0016842"
] | [] | [] | [] | [
"GO:0016842"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.3.2.1",
"skos:exactMatch RHEA:24020",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004057 | 4,057 | arginyl-tRNA--protein transferase activity | molecular_function | Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg). | [
"PMID:16492767",
"PMID:9858543",
"RHEA:10208"
] | null | [
"arginine transferase activity",
"arginyl-tRNA protein transferase activity",
"arginyltransferase activity"
] | [
"BROAD",
"EXACT",
"BROAD"
] | [
"GO:0042172"
] | [] | [
"EC:2.3.2.8",
"MetaCyc:ARGINYLTRANSFERASE-RXN",
"RHEA:10208"
] | [
"GO:0016755",
"GO:0140096",
"GO:0140101"
] | [] | [] | [] | [
"GO:0016755",
"GO:0140096",
"GO:0140101"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.2.8",
"skos:exactMatch RHEA:10208",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25493\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30124\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 6 |
GO:0004058 | 4,058 | aromatic-L-amino-acid decarboxylase activity | molecular_function | Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. | [
"EC:4.1.1.28"
] | null | [
"5-hydroxytryptophan decarboxylase activity",
"aromatic amino acid decarboxylase activity",
"aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)",
"aromatic-L-amino-acid carboxy-lyase activity",
"DOPA decarboxylase activity",
"hydroxytryptophan decarboxylase activity",
"L-DOPA decarboxylase activit... | [
"NARROW",
"RELATED",
"NARROW",
"RELATED",
"NARROW",
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0016400"
] | [] | [
"EC:4.1.1.28",
"MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN",
"Reactome:R-HSA-209859 \"Decarboxylation of 5-hydroxytryptophan forms serotonin\"",
"Reactome:R-HSA-209924 \"Dopa is decarboxylated to dopamine\""
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.28",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004059 | 4,059 | aralkylamine N-acetyltransferase activity | molecular_function | Catalysis of the reaction: a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H+. | [
"RHEA:20497"
] | null | [
"AANAT activity",
"acetyl-CoA:2-arylethylamine N-acetyltransferase activity",
"arylalkylamine N-acetyltransferase activity",
"melatonin rhythm enzyme activity",
"serotonin acetylase activity",
"serotonin acetyltransferase activity",
"serotonin N-acetyltransferase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"NARROW",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:2.3.1.87",
"MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-209792 \"N-acetylation of serotonin\"",
"RHEA:20497",
"RHEA:25217",
"RHEA:51388",
"RHEA:66136",
"RHEA:66140",
"RHEA:66144",
"RHEA:66148",
"RHEA:66152",
"RHEA:66196"
] | [
"GO:0008080"
] | [] | [] | [] | [
"GO:0008080"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.87",
"skos:exactMatch RHEA:20497",
"skos:narrowMatch RHEA:25217",
"skos:narrowMatch RHEA:51388",
"skos:narrowMatch RHEA:66136",
"skos:narrowMatch RHEA:66140",
"skos:narrowMatch RHEA:66144",
"skos:narrowMatch RHEA:66148",
"skos:narrowMatch RHEA:66152",
"skos:narrowMatch RH... | null | null | false | true | 7 |
GO:0004060 | 4,060 | arylamine N-acetyltransferase activity | molecular_function | Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. | [
"EC:2.3.1.5"
] | null | [
"2-naphthylamine N-acetyltransferase activity",
"4-aminobiphenyl N-acetyltransferase activity",
"acetyl CoA-arylamine N-acetyltransferase activity",
"acetyl-CoA:arylamine N-acetyltransferase activity",
"arylamine acetylase activity",
"arylamine acetyltransferase activity",
"beta-naphthylamine N-acetyltr... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.3.1.5",
"MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN",
"Reactome:R-HSA-174963 \"NAT1 acetylation\"",
"Reactome:R-HSA-174967 \"NAT2 acetylation\"",
"Reactome:R-HSA-9753676 \"NAT1,2 acetylate APAP-Cys to APAP-Mer\"",
"RHEA:14241",
"RHEA:16613",
"RHEA:56316",
"UM-BBD_reactionID:r1333",
"UM-BBD_re... | [
"GO:0008080"
] | [] | [] | [] | [
"GO:0008080"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.3.1.5",
"skos:exactMatch RHEA:16613",
"skos:narrowMatch RHEA:14241",
"skos:narrowMatch RHEA:56316",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004061 | 4,061 | arylformamidase activity | molecular_function | Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. | [
"EC:3.5.1.9"
] | null | [
"aryl-formylamine amidohydrolase activity",
"formamidase I",
"formamidase II",
"formylase activity",
"formylkynureninase activity",
"formylkynurenine formamidase activity",
"kynurenine formamidase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.9",
"MetaCyc:ARYLFORMAMIDASE-RXN",
"Reactome:R-HSA-71189 \"AFMID hydrolyses NFK to L-KYN\"",
"RHEA:13009"
] | [
"GO:0016811"
] | [] | [] | [] | [
"GO:0016811"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.5.1.9",
"skos:exactMatch RHEA:13009",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 8 |
GO:0004062 | 4,062 | aryl sulfotransferase activity | molecular_function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. | [
"EC:2.8.2.1"
] | null | [
"1-naphthol phenol sulfotransferase activity",
"2-naphtholsulfotransferase activity",
"3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity",
"4-nitrocatechol sulfokinase activity",
"aryl sulphotransferase activity",
"arylsulfotransferase",
"dopamine sulfotransferase activity",
"p-nitrophenol s... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [
"goslim_chembl"
] | [
"EC:2.8.2.1",
"MetaCyc:ARYL-SULFOTRANSFERASE-RXN",
"Reactome:R-HSA-158468 \"SULT1A1 dimer sulfonates PARA to PARA-SO4\"",
"Reactome:R-HSA-158849 \"Phenol can form a sulfate conjugate\"",
"Reactome:R-HSA-158860 \"SULT1A1 dimer sulfonates NHABP\"",
"Reactome:R-HSA-159358 \"SULT1A3,4 dimers sulfate DA to DAO... | [
"GO:0008146"
] | [] | [] | [] | [
"GO:0008146"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.8.2.1",
"skos:exactMatch RHEA:12164",
"skos:narrowMatch RHEA:66548",
"skos:narrowMatch RHEA:66572",
"skos:narrowMatch RHEA:66576",
"skos:narrowMatch RHEA:66580",
"skos:narrowMatch RHEA:67876",
"skos:narrowMatch RHEA:67888",
"skos:narrowMatch RHEA:67892",
"skos:narrowMatch RHE... | null | null | false | true | 2 |
GO:0004063 | 4,063 | aryldialkylphosphatase activity | molecular_function | Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. | [
"EC:3.1.8.1"
] | null | [
"A-esterase activity",
"aryltriphosphatase activity",
"aryltriphosphate dialkylphosphohydrolase activity",
"esterase B1",
"esterase E4",
"OPH",
"organophosphate esterase activity",
"organophosphate hydrolase activity",
"organophosphorus acid anhydrase activity",
"organophosphorus hydrolase activit... | [
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"BROAD",
"NARROW",
"BROAD",
"BROAD",
"NARROW",
"NARROW"
] | [] | [] | [
"EC:3.1.8.1",
"MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN",
"RHEA:18053",
"UM-BBD_enzymeID:r0067",
"UM-BBD_reactionID:r0064"
] | [
"GO:0016795"
] | [] | [] | [] | [
"GO:0016795"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.8.1",
"skos:exactMatch RHEA:18053",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0004064 | 4,064 | arylesterase activity | molecular_function | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. | [
"EC:3.1.1.2"
] | null | [
"A-esterase activity",
"aromatic esterase",
"aryl-ester hydrolase",
"paraoxonase activity"
] | [
"BROAD",
"NARROW",
"NARROW",
"BROAD"
] | [] | [] | [
"EC:3.1.1.2",
"MetaCyc:ARYLESTERASE-RXN",
"RHEA:17309",
"UM-BBD_reactionID:r0757"
] | [
"GO:0052689"
] | [] | [] | [] | [
"GO:0052689"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.2",
"skos:exactMatch RHEA:17309",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0004065 | 4,065 | arylsulfatase activity | molecular_function | Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. | [
"EC:3.1.6.1"
] | null | [
"4-methylumbelliferyl sulfatase activity",
"aryl-sulfate sulfohydrolase activity",
"aryl-sulfate sulphohydrolase activity",
"aryl-sulphate sulphohydrolase activity",
"arylsulfohydrolase activity",
"arylsulphatase activity",
"estrogen sulfatase activity",
"nitrocatechol sulfatase activity",
"p-nitrop... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.1.6.1",
"MetaCyc:ARYLSULFAT-RXN",
"RHEA:17261"
] | [
"GO:0008484"
] | [] | [] | [] | [
"GO:0008484"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.6.1",
"skos:exactMatch RHEA:17261",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0004066 | 4,066 | asparagine synthase (glutamine-hydrolyzing) activity | molecular_function | Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. | [
"EC:6.3.5.4",
"RHEA:12228"
] | null | [
"AS",
"AS-B activity",
"asparagine synthase (glutamine-hydrolysing)",
"asparagine synthetase (glutamine-hydrolysing)",
"asparagine synthetase (glutamine-hydrolyzing) activity",
"asparagine synthetase B activity",
"glutamine-dependent asparagine synthetase activity",
"L-aspartate:L-glutamine amido-liga... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.5.4",
"MetaCyc:ASNSYNB-RXN",
"Reactome:R-HSA-70599 \"aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]\"",
"RHEA:12228"
] | [
"GO:0016884"
] | [] | [] | [] | [
"GO:0016884"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.5.4",
"skos:exactMatch RHEA:12228",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004067 | 4,067 | asparaginase activity | molecular_function | Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. | [
"EC:3.5.1.1"
] | null | [
"alpha-asparaginase activity",
"asparaginase II",
"colaspase activity",
"crasnitin",
"elspar",
"L-asparaginase activity",
"L-asparagine amidohydrolase activity",
"leunase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:3.5.1.1",
"Reactome:R-HSA-6797627 \"ASPG hydrolyses L-Asn to L-Asp\"",
"RHEA:21016"
] | [
"GO:0004040"
] | [] | [] | [] | [
"GO:0004040"
] | [] | [] | [] | [] | [] | [
"skos:broadMatch MetaCyc:ASPARAGHYD-RXN",
"skos:exactMatch EC:3.5.1.1",
"skos:exactMatch RHEA:21016",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28070\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28176\" xsd:anyURI",
"term_tracker_item... | null | null | false | true | 1 |
GO:0004068 | 4,068 | aspartate 1-decarboxylase activity | molecular_function | Catalysis of the reaction: L-aspartate = beta-alanine + CO2. | [
"EC:4.1.1.11"
] | null | [
"aspartate alpha-decarboxylase activity",
"aspartic alpha-decarboxylase",
"L-aspartate 1-carboxy-lyase (beta-alanine-forming)",
"L-aspartate 1-carboxy-lyase activity",
"L-aspartate alpha-decarboxylase activity"
] | [
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:4.1.1.11",
"MetaCyc:ASPDECARBOX-RXN",
"RHEA:19497"
] | [
"GO:0016831"
] | [] | [] | [] | [
"GO:0016831"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:4.1.1.11",
"skos:exactMatch MetaCyc:ASPDECARBOX-RXN",
"skos:exactMatch RHEA:19497",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31587\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004069 | 4,069 | L-aspartate:2-oxoglutarate transaminase activity | molecular_function | Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. | [
"RHEA:21824"
] | null | [
"2-oxoglutarate-glutamate aminotransferase activity",
"AAT",
"aspartate alpha-ketoglutarate transaminase activity",
"aspartate aminotransferase activity",
"aspartate transaminase activity",
"aspartate-2-oxoglutarate transaminase activity",
"aspartate:2-oxoglutarate aminotransferase activity",
"asparti... | [
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"BROAD",
"BROAD",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"EX... | [] | [] | [
"EC:2.6.1.1",
"KEGG_REACTION:R00355",
"MetaCyc:ASPAMINOTRANS-RXN",
"Reactome:R-HSA-70581 \"oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]\"",
"Reactome:R-HSA-70592 \"PXLP-K259-GOT1 transaminates 2-OG and L-Asp\"",
"Reactome:R-HSA-70596 \"GOT2 dimer transaminates L-Asp\"",
"Reactome:... | [
"GO:0140385"
] | [] | [] | [] | [
"GO:0140385"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.6.1.1",
"skos:exactMatch RHEA:21824",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontolo... | null | null | false | true | 3 |
GO:0004070 | 4,070 | aspartate carbamoyltransferase activity | molecular_function | Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. | [
"EC:2.1.3.2",
"RHEA:20013"
] | null | [
"aspartate carbamyltransferase activity",
"aspartate transcarbamoylase activity",
"aspartate transcarbamylase activity",
"aspartic acid transcarbamoylase activity",
"aspartic carbamyltransferase activity",
"aspartic transcarbamylase activity",
"ATCase activity",
"carbamoyl-phosphate:L-aspartate carbam... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.1.3.2",
"KEGG_REACTION:R01397",
"MetaCyc:ASPCARBTRANS-RXN",
"Reactome:R-HSA-73573 \"CAD hexamer transforms CAP to N-carb-L-Asp\"",
"RHEA:20013"
] | [
"GO:0016743"
] | [] | [] | [] | [
"GO:0016743"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.1.3.2",
"skos:exactMatch RHEA:20013",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004071 | 4,071 | aspartate-ammonia ligase activity | molecular_function | Catalysis of the reaction: ATP + L-aspartate + NH4+ = AMP + diphosphate + L-asparagine. | [
"RHEA:11372"
] | null | [
"asparagine synthetase activity",
"L-asparagine synthetase activity",
"L-aspartate:ammonia ligase (AMP-forming)"
] | [
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.1.1",
"MetaCyc:ASNSYNA-RXN",
"RHEA:11372"
] | [
"GO:0016211"
] | [] | [] | [] | [
"GO:0016211"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.1.1",
"skos:exactMatch RHEA:11372",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004072 | 4,072 | aspartate kinase activity | molecular_function | Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. | [
"EC:2.7.2.4",
"RHEA:23776"
] | null | [
"aspartic kinase activity",
"aspartokinase activity",
"ATP:L-aspartate 4-phosphotransferase activity",
"beta-aspartokinase activity"
] | [
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.7.2.4",
"KEGG_REACTION:R00480",
"MetaCyc:ASPARTATEKIN-RXN",
"RHEA:23776"
] | [
"GO:0016774",
"GO:0019202"
] | [] | [] | [] | [
"GO:0016774",
"GO:0019202"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.7.2.4",
"skos:exactMatch RHEA:23776",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0004073 | 4,073 | aspartate-semialdehyde dehydrogenase activity | molecular_function | Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP+ + phosphate = 4-phospho-L-aspartate + H+ + NADPH. | [
"EC:1.2.1.11",
"RHEA:24284"
] | null | [
"ASA dehydrogenase activity",
"aspartate semialdehyde dehydrogenase activity",
"aspartic beta-semialdehyde dehydrogenase activity",
"aspartic semialdehyde dehydrogenase activity",
"L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)",
"L-aspartate-beta-semialdehyde dehydrogenase activity",
... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.2.1.11",
"KEGG_REACTION:R02291",
"MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN",
"RHEA:24284"
] | [
"GO:0016620"
] | [] | [] | [] | [
"GO:0016620"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.2.1.11",
"skos:exactMatch RHEA:24284",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0004074 | 4,074 | biliverdin reductase [NAD(P)H] activity | molecular_function | Catalysis of the reaction: bilirubin IXalpha + NAD(P)+ = biliverdin IXalpha + NAD(P)H + H+. | [
"EC:1.3.1.24"
] | null | [
"bilirubin:NAD(P)+ oxidoreductase activity",
"biliverdin reductase [NAD(P)+] activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [
"EC:1.3.1.24",
"MetaCyc:BILIVERDIN-REDUCTASE-RXN",
"Reactome:R-HSA-189384 \"BLVRA:Zn2+, BLVRB reduce BV to BIL\""
] | [
"GO:0016628"
] | [] | [] | [] | [
"GO:0016628"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.3.1.24",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27180\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30105\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004075 | 4,075 | biotin carboxylase activity | molecular_function | Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. | [
"EC:6.3.4.14"
] | null | [
"biotin carboxylase (component of acetyl CoA carboxylase) activity",
"biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.14",
"MetaCyc:BIOTIN-CARBOXYL-RXN",
"RHEA:13501"
] | [
"GO:0016879"
] | [] | [] | [] | [
"GO:0016879"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.14",
"skos:exactMatch RHEA:13501",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0004076 | 4,076 | biotin synthase activity | molecular_function | Catalysis of the reaction: (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = [sulfur carrier]-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]. | [
"EC:2.8.1.6",
"RHEA:22060"
] | null | [
"biotin synthetase activity",
"dethiobiotin:sulfur sulfurtransferase activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:2.8.1.6",
"KEGG_REACTION:R01078",
"MetaCyc:2.8.1.6-RXN",
"RHEA:22060"
] | [
"GO:0016783"
] | [] | [] | [] | [
"GO:0016783"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.8.1.6",
"skos:exactMatch RHEA:22060",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29748\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0004077 | 4,077 | biotin--[biotin carboxyl-carrier protein] ligase activity | molecular_function | Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein]. | [
"RHEA:11756"
] | null | [
"acetyl CoA holocarboxylase synthetase activity",
"acetyl coenzyme A holocarboxylase synthetase activity",
"acetyl-CoA carboxylase biotin holoenzyme synthetase activity",
"biotin holoenzyme synthetase activity",
"biotin--[acetyl-CoA carboxylase] synthetase activity",
"biotin--protein ligase activity",
"... | [
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"RELATED",
"BROAD",
"RELATED",
"EXACT",
"RELATED",
"RELATED",
"RELATED"
] | [] | [] | [
"EC:6.3.4.10",
"EC:6.3.4.11",
"EC:6.3.4.15",
"EC:6.3.4.9",
"MetaCyc:6.3.4.10-RXN",
"MetaCyc:6.3.4.11-RXN",
"MetaCyc:6.3.4.9-RXN",
"MetaCyc:BIOTINLIG-RXN",
"Reactome:R-HSA-2993447 \"HLCS biotinylates 6x(PCCA:PCCB)\"",
"Reactome:R-HSA-2993799 \"HLCS biotinylates 6xMCCC1:6xMCCC2\"",
"Reactome:R-HSA... | [
"GO:0016879",
"GO:0140096"
] | [] | [] | [] | [
"GO:0016879",
"GO:0140096"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:6.3.4.15",
"skos:exactMatch RHEA:11756",
"skos:narrowMatch EC:6.3.4.10",
"skos:narrowMatch EC:6.3.4.11",
"skos:narrowMatch EC:6.3.4.9",
"skos:narrowMatch MetaCyc:6.3.4.10-RXN",
"skos:narrowMatch MetaCyc:6.3.4.11-RXN",
"skos:narrowMatch MetaCyc:6.3.4.9-RXN",
"skos:narrowMatch RHEA... | null | null | false | true | 1 |
GO:0004078 | 4,078 | obsolete biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). | [
"GOC:rynl"
] | The reason for obsoletion is this term is more specific than the specificity of any known gene product. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004077"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28107\" xsd:anyURI"
] | null | null | true | true | 3 |
GO:0004079 | 4,079 | obsolete biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). | [
"GOC:rynl"
] | The reason for obsoletion is this term is more specific than the specificity of any known gene product. | [
"biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004077"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28107\" xsd:anyURI"
] | null | null | true | true | 5 |
GO:0004080 | 4,080 | obsolete biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity | molecular_function | OBSOLETE. Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)). | [
"GOC:rynl"
] | The reason for obsoletion is this term is more specific than the specificity of any known gene product. | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0004077"
] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28107\" xsd:anyURI"
] | null | null | true | true | 6 |
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