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GO

Dataset card Data Studio Files
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 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0099139
99,139
cheating during chimeric sorocarp development
biological_process
Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes.
[ "PMID:18272966" ]
null
[]
[]
[]
[]
[]
[ "GO:1901261" ]
[ "part_of GO:0099134" ]
[ "part_of" ]
[ "GO:0099134" ]
[ "GO:0099134", "GO:1901261" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099140
99,140
presynaptic actin cytoskeleton organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0030036", "GO:0099187" ]
[]
[]
[]
[ "GO:0030036", "GO:0099187" ]
[]
[]
[]
[]
[]
[]
dos
2017-06-09T18:34:19Z
false
true
9
GO:0099141
99,141
cellular response to protozoan
biological_process
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
[ "GOC:dos" ]
null
[]
[]
[]
[]
[]
[ "GO:0001562" ]
[]
[]
[]
[ "GO:0001562" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099142
99,142
intracellularly ATP-gated ion channel activity
molecular_function
Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
[ "PMID:9755289" ]
null
[]
[]
[]
[]
[]
[ "GO:0005217", "GO:0035381" ]
[]
[]
[]
[ "GO:0005217", "GO:0035381" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099143
99,143
presynaptic actin cytoskeleton
cellular_component
The actin cytoskeleton that is part of a presynapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0015629", "GO:0099569" ]
[]
[]
[]
[ "GO:0015629", "GO:0099569" ]
[ "GO:0015629", "part_of GO:0098793" ]
[]
[]
[]
[]
[]
dos
2017-06-09T18:36:19Z
false
true
6
GO:0099144
99,144
obsolete anchored component of synaptic membrane
cellular_component
OBSOLETE. The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
[ "GOC:dos" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0097060" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-05-25T17:25:19Z
true
true
8
GO:0099145
99,145
regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
biological_process
Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0017157", "GO:0051223", "GO:0065008", "GO:1902683", "GO:1904375", "GO:1905475" ]
[ "regulates GO:0098967" ]
[ "regulates" ]
[ "GO:0098967" ]
[ "GO:0017157", "GO:0051223", "GO:0065008", "GO:0098967", "GO:1902683", "GO:1904375", "GO:1905475" ]
[ "GO:0065007", "regulates GO:0098967" ]
[]
[]
[]
[]
[]
dos
2017-06-09T18:49:26Z
false
true
7
GO:0099146
99,146
obsolete intrinsic component of postsynaptic density membrane
cellular_component
OBSOLETE. The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
[ "GOC:dos", "GOC:mah" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[ "intrinsic to postsynaptic specialization membrane" ]
[ "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0098839" ]
[]
[]
dos
2017-07-05T10:43:24Z
true
true
9
GO:0099147
99,147
extrinsic component of postsynaptic density membrane
cellular_component
The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
[ "GOC:autophagy", "GOC:mf" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0098892" ]
[ "part_of GO:0098839" ]
[ "part_of" ]
[ "GO:0098839" ]
[ "GO:0098839", "GO:0098892" ]
[ "GO:0019898", "part_of GO:0098839" ]
[]
[]
[]
[]
[]
dos
2017-07-05T10:44:43Z
false
true
3
GO:0099149
99,149
regulation of postsynaptic neurotransmitter receptor internalization
biological_process
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
[ "GOC:ai" ]
null
[ "regulation of postsynaptic neurotransmitter receptor endocytosis" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0002090", "GO:0065008" ]
[ "regulates GO:0098884" ]
[ "regulates" ]
[ "GO:0098884" ]
[ "GO:0002090", "GO:0065008", "GO:0098884" ]
[ "GO:0065007", "regulates GO:0098884" ]
[]
[]
[]
[]
[]
dos
2017-07-05T13:13:49Z
false
true
4
GO:0099150
99,150
regulation of postsynaptic specialization assembly
biological_process
Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:1902115" ]
[ "regulates GO:0098698" ]
[ "regulates" ]
[ "GO:0098698" ]
[ "GO:0098698", "GO:1902115" ]
[ "GO:0065007", "regulates GO:0098698" ]
[]
[]
[]
[]
[]
dos
2017-07-05T13:20:48Z
false
true
9
GO:0099152
99,152
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
biological_process
Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
[ "GOC:dos", "PMID:20098723" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0065008", "GO:1902473", "GO:1902683", "GO:1905749" ]
[ "regulates GO:0098887" ]
[ "regulates" ]
[ "GO:0098887" ]
[ "GO:0065008", "GO:0098887", "GO:1902473", "GO:1902683", "GO:1905749" ]
[ "GO:0065007", "regulates GO:0098887" ]
[]
[]
[]
[]
[]
dos
2017-08-25T15:01:11Z
false
true
9
GO:0099153
99,153
synaptic transmission, serotonergic
biological_process
The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cy...
[ "GOC:dos", "GOC:dph" ]
null
[ "serotonergic synaptic transmission" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0007268" ]
[]
[]
[]
[ "GO:0007268" ]
[]
[]
[]
[]
[]
[]
dos
2017-07-05T14:16:51Z
false
true
3
GO:0099154
99,154
serotonergic synapse
cellular_component
A synapse that uses serotonin as a neurotransmitter.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0045202" ]
[]
[]
[]
[ "GO:0045202" ]
[]
[]
[]
[]
[]
[]
dos
2017-07-05T14:22:05Z
false
true
5
GO:0099155
99,155
synaptic transmission, noradrenergic
biological_process
The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of...
[ "GOC:dos", "GOC:dph" ]
null
[ "noradrenergic synaptic transmission" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0007268" ]
[]
[]
[]
[ "GO:0007268" ]
[]
[]
[]
[]
[]
[]
dos
2017-07-05T14:36:55Z
false
true
3
GO:0099156
99,156
cell-cell signaling via exosome
biological_process
Cell-cell signaling in which the ligand is carried between cells by an exosome.
[ "GOC:dos", "PMID:19837038" ]
null
[ "exosome mediated" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0007267" ]
[]
[]
[]
[ "GO:0007267" ]
[]
[]
[]
[]
[]
[]
dos
2017-07-05T16:40:45Z
false
true
6
GO:0099157
99,157
trans-synaptic signaling via exosome
biological_process
Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
[ "GOC:dos", "PMID:19837038" ]
null
[ "exosome mediated transynaptic signalling", "trans-synaptic signalling via exosome" ]
[ "EXACT", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099156", "GO:0099537" ]
[]
[]
[]
[ "GO:0099156", "GO:0099537" ]
[]
[]
[]
[]
[]
[]
dos
2017-07-05T16:49:44Z
false
true
3
GO:0099158
99,158
regulation of recycling endosome localization within postsynapse
biological_process
Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
[ "GOC:dos", "PMID:20098723" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0032386", "GO:1903421" ]
[ "regulates GO:0036466" ]
[ "regulates" ]
[ "GO:0036466" ]
[ "GO:0032386", "GO:0036466", "GO:1903421" ]
[ "GO:0065007", "regulates GO:0036466" ]
[]
[]
[]
[]
[]
dos
2017-08-25T15:37:50Z
false
true
9
GO:0099159
99,159
regulation of modification of postsynaptic structure
biological_process
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
[ "GOC:dos" ]
null
[ "regulation of postsynapse remodelling" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:1905244" ]
[ "regulates GO:0099010" ]
[ "regulates" ]
[ "GO:0099010" ]
[ "GO:0099010", "GO:1905244" ]
[ "GO:0065007", "regulates GO:0099010" ]
[]
[]
[]
[]
[]
dos
2017-08-25T15:47:55Z
false
true
8
GO:0099160
99,160
postsynaptic intermediate filament cytoskeleton
cellular_component
The intermediate filament cytoskeleton that is part of a postsynapse.
[ "GOC:dos", "PMID:25869803" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0045111", "GO:0099571" ]
[]
[]
[]
[ "GO:0045111", "GO:0099571" ]
[ "GO:0045111", "part_of GO:0098794" ]
[]
[]
[]
[]
[]
dos
2017-08-28T15:26:08Z
false
true
6
GO:0099161
99,161
regulation of presynaptic dense core granule exocytosis
biological_process
Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
[ "GOC:dos", "PMID:17881523" ]
null
[ "regulation of presynaptic dense core vesicle exocytosis" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099171", "GO:1903233", "GO:1905413" ]
[ "regulates GO:0099525" ]
[ "regulates" ]
[ "GO:0099525" ]
[ "GO:0099171", "GO:0099525", "GO:1903233", "GO:1905413" ]
[ "GO:0065007", "regulates GO:0099525" ]
[]
[]
[]
[]
[]
dos
2017-09-10T10:59:08Z
false
true
6
GO:0099162
99,162
regulation of neurotransmitter loading into synaptic vesicle
biological_process
Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
[ "GOC:dos", "PMID:25176177" ]
null
[ "regulation of neurotransmitter uptake into synaptic vesicle", "regulation of synaptic vesicle neurotransmitter loading" ]
[ "EXACT", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0051588", "GO:0098693" ]
[ "regulates GO:0098700" ]
[ "regulates" ]
[ "GO:0098700" ]
[ "GO:0051588", "GO:0098693", "GO:0098700" ]
[ "GO:0065007", "regulates GO:0098700" ]
[]
[]
[]
[]
[]
dos
2017-09-10T11:07:57Z
false
true
9
GO:0099163
99,163
synaptic signaling by nitric oxide
biological_process
Cell-cell signaling to or from a synapse, mediated by nitric oxide.
[ "GOC:dos", "PMID:19038221" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099536" ]
[]
[]
[]
[ "GO:0099536" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099164
99,164
postsynaptic specialization membrane of symmetric synapse
cellular_component
The membrane component of the postsynaptic specialization of a symmetric synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099634" ]
[ "part_of GO:0099629" ]
[ "part_of" ]
[ "GO:0099629" ]
[ "GO:0099629", "GO:0099634" ]
[ "GO:0016020", "part_of GO:0045211", "part_of GO:0099629" ]
[]
[]
[]
[]
[]
dos
2017-09-10T11:50:44Z
false
true
5
GO:0099165
99,165
postsynaptic specialization of symmetric synapse, intracellular component
cellular_component
A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not...
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099091" ]
[ "part_of GO:0099629" ]
[ "part_of" ]
[ "GO:0099629" ]
[ "GO:0099091", "GO:0099629" ]
[ "GO:0043228", "part_of GO:0099629" ]
[]
[]
[]
[]
[]
dos
2017-09-10T11:54:15Z
false
true
7
GO:0099166
99,166
obsolete intrinsic component of postsynaptic specialization membrane of symmetric synapse
cellular_component
OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly ...
[ "GOC:dos" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[ "intrinsic to postsynaptic specialization membrane of symmetric synapse" ]
[ "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0099164" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-09-10T11:56:47Z
true
true
9
GO:0099167
99,167
obsolete integral component of postsynaptic specialization membrane of symmetric synapse
cellular_component
OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
[ "GOC:dos" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0099164" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-09-10T11:58:46Z
true
true
5
GO:0099168
99,168
obsolete extrinsic component of postsynaptic specialization membrane of symmetric synapse
cellular_component
OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
[ "GOC:dos" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0099164" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-09-10T12:00:26Z
true
true
1
GO:0099169
99,169
obsolete anchored component of postsynaptic specialization membrane of symmetric synapse
cellular_component
OBSOLETE. The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membran...
[ "GOC:dos" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0099164" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-09-10T12:01:53Z
true
true
5
GO:0099170
99,170
postsynaptic modulation of chemical synaptic transmission
biological_process
Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0050804" ]
[ "occurs_in GO:0098794" ]
[ "occurs_in" ]
[ "GO:0098794" ]
[ "GO:0050804", "GO:0098794" ]
[ "GO:0050804", "occurs_in GO:0098794" ]
[]
[]
[]
[]
[]
dos
2017-09-11T17:09:17Z
false
true
1
GO:0099171
99,171
presynaptic modulation of chemical synaptic transmission
biological_process
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0050804" ]
[ "occurs_in GO:0098793" ]
[ "occurs_in" ]
[ "GO:0098793" ]
[ "GO:0050804", "GO:0098793" ]
[ "GO:0050804", "occurs_in GO:0098793" ]
[]
[]
[]
[]
[]
dos
2017-09-11T17:09:31Z
false
true
7
GO:0099173
99,173
postsynapse organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
[ "GOC:dos" ]
null
[ "postsynapse development", "postsynapse morphogenesis", "postsynapse organisation", "postsynapse organization and biogenesis" ]
[ "EXACT", "RELATED", "EXACT", "RELATED" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0016043" ]
[ "part_of GO:0050808" ]
[ "part_of" ]
[ "GO:0050808" ]
[ "GO:0016043", "GO:0050808" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099174
99,174
regulation of presynapse organization
biological_process
Any process that modulates the physical form of a presynapse.
[ "GOC:ai", "GOC:dph", "GOC:tb" ]
null
[ "regulation of presynapse organisation", "regulation of presynapse organization and biogenesis", "regulation of presynapse structure" ]
[ "EXACT", "RELATED", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0050807" ]
[ "regulates GO:0099172" ]
[ "regulates" ]
[ "GO:0099172" ]
[ "GO:0050807", "GO:0099172" ]
[ "GO:0065007", "regulates GO:0099172" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0099176
99,176
regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
biological_process
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
[ "GOC:dos", "PMID:23209303" ]
null
[ "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling" ]
[ "RELATED" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099177" ]
[ "regulates GO:0098942" ]
[ "regulates" ]
[ "GO:0098942" ]
[ "GO:0098942", "GO:0099177" ]
[ "GO:0065007", "regulates GO:0098942" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099177
99,177
regulation of trans-synaptic signaling
biological_process
Any process that modulates the frequency, rate or extent of trans-synaptic signaling.
[ "GOC:dos" ]
null
[]
[]
[]
[]
[]
[ "GO:0010646", "GO:0023051" ]
[ "regulates GO:0099537" ]
[ "regulates" ]
[ "GO:0099537" ]
[ "GO:0010646", "GO:0023051", "GO:0099537" ]
[ "GO:0065007", "regulates GO:0099537" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099178
99,178
regulation of retrograde trans-synaptic signaling by endocanabinoid
biological_process
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.
[ "GOC:dos", "PMID:15664177" ]
null
[ "regulation of endocannabinoid-mediated retrograde trans-synaptic signaling" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0099177" ]
[ "regulates GO:0098921" ]
[ "regulates" ]
[ "GO:0098921" ]
[ "GO:0098921", "GO:0099177" ]
[ "GO:0065007", "regulates GO:0098921" ]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0099179
99,179
regulation of synaptic membrane adhesion
biological_process
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
[ "GOC:dos" ]
null
[ "regulation of synapse adhesion between pre- and post-synapse" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0022407", "GO:0050807" ]
[ "regulates GO:0099560" ]
[ "regulates" ]
[ "GO:0099560" ]
[ "GO:0022407", "GO:0050807", "GO:0099560" ]
[ "GO:0065007", "regulates GO:0099560" ]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099180
99,180
zinc ion import into synaptic vesicle
biological_process
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
[ "PMID:9990090" ]
null
[ "zinc import into synaptic vesicle", "Zn2+ import into synaptic vesicle" ]
[ "EXACT", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0010496", "GO:0062111" ]
[]
[]
[]
[ "GO:0010496", "GO:0062111" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0099181
99,181
structural constituent of presynapse
molecular_function
The action of a molecule that contributes to the structural integrity of a presynapse.
[ "GOC:dos", "PMID:23751498" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0098918" ]
[ "occurs_in GO:0098793", "part_of GO:0099172" ]
[ "occurs_in", "part_of" ]
[ "GO:0098793", "GO:0099172" ]
[ "GO:0098793", "GO:0098918", "GO:0099172" ]
[ "GO:0005198", "occurs_in GO:0098793", "part_of GO:0099172" ]
[]
[]
[]
[]
[]
dos
2017-12-20T13:42:46Z
false
true
1
GO:0099182
99,182
presynaptic intermediate filament cytoskeleton
cellular_component
The intermediate filament cytoskeleton that is part of a presynapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0045111", "GO:0099569" ]
[]
[]
[]
[ "GO:0045111", "GO:0099569" ]
[ "GO:0045111", "part_of GO:0098793" ]
[]
[]
[]
[]
[]
dos
2017-12-01T18:10:21Z
false
true
5
GO:0099183
99,183
trans-synaptic signaling by BDNF, modulating synaptic transmission
biological_process
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
[ "GOC:dos" ]
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099191", "GO:0099550" ]
[]
[]
[]
[ "GO:0099191", "GO:0099550" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-01T18:25:24Z
false
true
8
GO:0099184
99,184
structural constituent of postsynaptic intermediate filament cytoskeleton
molecular_function
The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005200", "GO:0099186" ]
[ "occurs_in GO:0099160", "part_of GO:0099185" ]
[ "occurs_in", "part_of" ]
[ "GO:0099160", "GO:0099185" ]
[ "GO:0005200", "GO:0099160", "GO:0099185", "GO:0099186" ]
[ "GO:0005198", "occurs_in GO:0099160", "part_of GO:0099185" ]
[]
[]
[]
[]
[]
dos
2017-12-20T13:45:35Z
false
true
7
GO:0099185
99,185
postsynaptic intermediate filament cytoskeleton organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0045104", "GO:0099188" ]
[]
[]
[]
[ "GO:0045104", "GO:0099188" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T13:47:30Z
false
true
1
GO:0099186
99,186
structural constituent of postsynapse
molecular_function
The action of a molecule that contributes to the structural integrity of a postsynapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0098918" ]
[ "occurs_in GO:0098794", "part_of GO:0099173" ]
[ "occurs_in", "part_of" ]
[ "GO:0098794", "GO:0099173" ]
[ "GO:0098794", "GO:0098918", "GO:0099173" ]
[ "GO:0005198", "occurs_in GO:0098794", "part_of GO:0099173" ]
[]
[]
[]
[]
[]
dos
2017-12-20T14:54:33Z
false
true
3
GO:0099187
99,187
presynaptic cytoskeleton organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.
[ "GOC:dos" ]
null
[]
[]
[]
[]
[]
[ "GO:0007010" ]
[ "part_of GO:0099172" ]
[ "part_of" ]
[ "GO:0099172" ]
[ "GO:0007010", "GO:0099172" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T15:05:34Z
false
true
4
GO:0099188
99,188
postsynaptic cytoskeleton organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0007010" ]
[ "part_of GO:0099173" ]
[ "part_of" ]
[ "GO:0099173" ]
[ "GO:0007010", "GO:0099173" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T15:06:57Z
false
true
4
GO:0099189
99,189
postsynaptic spectrin-associated cytoskeleton
cellular_component
The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
[ "GOC:dos", "PMID:28576936" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0014731", "GO:0099571" ]
[]
[]
[]
[ "GO:0014731", "GO:0099571" ]
[ "GO:0014731", "part_of GO:0098794" ]
[]
[]
[]
[]
[]
dos
2017-12-20T15:29:09Z
false
true
8
GO:0099190
99,190
postsynaptic spectrin-associated cytoskeleton organization
biological_process
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
[ "GOC:dos", "PMID:28576936" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099188" ]
[]
[]
[]
[ "GO:0099188" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T15:34:26Z
false
true
6
GO:0099191
99,191
trans-synaptic signaling by BDNF
biological_process
Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.
[ "GOC:dos" ]
null
[ "trans-synaptic signaling by brain-derived neurotrophic factor" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099537" ]
[]
[]
[]
[ "GO:0099537" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T15:48:33Z
false
true
2
GO:0099192
99,192
cerebellar Golgi cell to granule cell synapse
cellular_component
A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
[ "PMID:26134650" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0045202" ]
[]
[]
[]
[ "GO:0045202" ]
[]
[]
[]
[]
[]
[]
dos
2017-12-20T16:12:25Z
false
true
1
GO:0099240
99,240
obsolete intrinsic component of synaptic membrane
cellular_component
OBSOLETE. The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
[ "GOC:dos", "GOC:mah" ]
This term was obsoleted because it represents protein topology, not a cellular component.
[ "intrinsic to synaptic membrane" ]
[ "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0097060" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23424\" xsd:anyURI" ]
dos
2017-05-25T17:23:21Z
true
true
7
GO:0099243
99,243
extrinsic component of synaptic membrane
cellular_component
The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0019897" ]
[ "part_of GO:0097060" ]
[ "part_of" ]
[ "GO:0097060" ]
[ "GO:0019897", "GO:0097060" ]
[ "GO:0019898", "part_of GO:0097060" ]
[]
[]
[]
[]
[]
dos
2017-05-25T17:24:23Z
false
true
2
GO:0099400
99,400
caveola neck
cellular_component
A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it.
[ "GOC:pad", "GOC:PARL", "PMID:17227843" ]
null
[]
[]
[]
[]
[]
[ "GO:0098590", "GO:0098857" ]
[ "part_of GO:0005901" ]
[ "part_of" ]
[ "GO:0005901" ]
[ "GO:0005901", "GO:0098590", "GO:0098857" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099401
99,401
caveola bulb
cellular_component
The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins.
[ "GOC:PARL", "GOC:POD", "PMID:17227843" ]
null
[ "caveola crater" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0098857" ]
[]
[]
[]
[ "GO:0098857" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099402
99,402
plant organ development
biological_process
Development of a plant organ, a multi-tissue plant structure that forms a functional unit.
[ "GOC:dos" ]
null
[ "development of a plant organ" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0048856" ]
[ "part_of GO:0048731" ]
[ "part_of" ]
[ "GO:0048731" ]
[ "GO:0048731", "GO:0048856" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0099404
99,404
mitotic sister chromatid cohesion, telomeric
biological_process
The cell cycle process in which telomeres of sister chromatids are joined during mitosis.
[ "GOC:BHF", "GOC:BHF_telomere", "GOC:mah", "GOC:rph", "PMID:26373281" ]
null
[ "mitotic sister chromatid cohesion at telomere", "sister chromatid cohesion at telomere at mitosis", "telomeric mitotic sister chromatin cohesion" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0007064" ]
[]
[]
[]
[ "GO:0007064" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099500
99,500
vesicle fusion to plasma membrane
biological_process
Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.
[ "GOC:aruk", "GOC:bc", "ISBN:0071120009", "PMID:18618940" ]
null
[]
[]
[]
[]
[]
[ "GO:0006906", "GO:0140029" ]
[]
[]
[]
[ "GO:0006906", "GO:0140029" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099501
99,501
exocytic vesicle membrane
cellular_component
The lipid bilayer surrounding an exocytic vesicle.
[ "GOC:dos" ]
null
[ "secretory vesicle membrane" ]
[ "BROAD" ]
[]
[]
[]
[ "GO:0030658" ]
[ "part_of GO:0070382" ]
[ "part_of" ]
[ "GO:0070382" ]
[ "GO:0030658", "GO:0070382" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0099502
99,502
calcium-dependent activation of synaptic vesicle fusion
biological_process
The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
[ "PMID:23060190" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0031632" ]
[ "part_of GO:0016079" ]
[ "part_of" ]
[ "GO:0016079" ]
[ "GO:0016079", "GO:0031632" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099503
99,503
secretory vesicle
cellular_component
A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_drosophila" ]
[]
[ "GO:0031410" ]
[]
[]
[]
[ "GO:0031410" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099504
99,504
synaptic vesicle cycle
biological_process
A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
[ "GOC:aruk", "GOC:bc", "PMID:15217342" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0051649", "GO:0099003" ]
[ "occurs_in GO:0098793" ]
[ "occurs_in" ]
[ "GO:0098793" ]
[ "GO:0051649", "GO:0098793", "GO:0099003" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099505
99,505
regulation of presynaptic membrane potential
biological_process
Any process that modulates the potential difference across a presynaptic membrane.
[ "GOC:dph", "GOC:ef" ]
null
[ "regulation of pre-synaptic membrane potential" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0042391" ]
[]
[]
[]
[ "GO:0042391" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0099506
99,506
synaptic vesicle transport along actin filament
biological_process
The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0030050", "GO:0099514" ]
[]
[]
[]
[ "GO:0030050", "GO:0099514" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0099507
99,507
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
molecular_function
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
[ "GOC:dos", "PMID:15145529", "PMID:19558451" ]
null
[ "ligand gated ion channel activity involved in regulation of presynaptic membrane potential", "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential", "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential", "ligand-gated ion c...
[ "EXACT", "EXACT", "EXACT", "EXACT", "BROAD" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0015276" ]
[ "occurs_in GO:0042734", "part_of GO:0099505" ]
[ "occurs_in", "part_of" ]
[ "GO:0042734", "GO:0099505" ]
[ "GO:0015276", "GO:0042734", "GO:0099505" ]
[ "GO:0015276", "part_of GO:0099505" ]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0099508
99,508
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
molecular_function
Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
[ "GOC:dos" ]
null
[ "voltage gated ion channel activity involved in regulation of presynaptic membrane potential", "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential", "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential", "voltage-gated i...
[ "EXACT", "EXACT", "EXACT", "EXACT", "BROAD" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005244" ]
[ "occurs_in GO:0042734", "part_of GO:0099505" ]
[ "occurs_in", "part_of" ]
[ "GO:0042734", "GO:0099505" ]
[ "GO:0005244", "GO:0042734", "GO:0099505" ]
[ "GO:0005244", "part_of GO:0099505" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24479\" xsd:anyURI" ]
null
null
false
true
9
GO:0099509
99,509
regulation of presynaptic cytosolic calcium ion concentration
biological_process
Any process that regulates the concentration of calcium in the presynaptic cytosol.
[ "GOC:dos" ]
null
[ "regulation of presynaptic cytosolic calcium levels" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0051480", "GO:0070050" ]
[ "occurs_in GO:0098793" ]
[ "occurs_in" ]
[ "GO:0098793" ]
[ "GO:0051480", "GO:0070050", "GO:0098793" ]
[ "GO:0051480", "occurs_in GO:0098793" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099510
99,510
obsolete calcium ion binding involved in regulation of cytosolic calcium ion concentration
molecular_function
OBSOLETE. The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations.
[ "PMID:24442513", "PMID:26190970" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[ "regulation of cytosolic calcium ion concentration by calcium ion buffering" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
8
GO:0099511
99,511
voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
molecular_function
Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005245" ]
[ "part_of GO:0051480" ]
[ "part_of" ]
[ "GO:0051480" ]
[ "GO:0005245", "GO:0051480" ]
[ "GO:0005245", "part_of GO:0051480" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0099512
99,512
supramolecular fiber
cellular_component
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
[ "GOC:dos" ]
null
[ "fibril" ]
[ "RELATED" ]
[ "GO:0043205" ]
[]
[]
[ "GO:0099081" ]
[]
[]
[]
[ "GO:0099081" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099513
99,513
polymeric cytoskeletal fiber
cellular_component
A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.
[ "GOC:dos" ]
null
[]
[]
[]
[]
[]
[ "GO:0099512" ]
[ "part_of GO:0005856" ]
[ "part_of" ]
[ "GO:0005856" ]
[ "GO:0005856", "GO:0099512" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0099514
99,514
synaptic vesicle cytoskeletal transport
biological_process
The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0048489", "GO:0099518" ]
[]
[]
[]
[ "GO:0048489", "GO:0099518" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099515
99,515
actin filament-based transport
biological_process
The transport of organelles or other particles from one location in the cell to another along actin filaments.
[ "GOC:dos", "GOC:dph", "GOC:mah", "GOC:tb" ]
null
[]
[]
[]
[]
[]
[ "GO:0030705" ]
[]
[]
[]
[ "GO:0030705" ]
[]
[]
[]
[]
[]
[]
tb
2009-05-27T10:56:08Z
false
true
7
GO:0099517
99,517
synaptic vesicle transport along microtubule
biological_process
The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0047496", "GO:0099514" ]
[]
[]
[]
[ "GO:0047496", "GO:0099514" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099518
99,518
vesicle cytoskeletal trafficking
biological_process
The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.
[ "GOC:ecd", "GOC:rl" ]
null
[ "cytoskeletal fiber-based vesicle localization", "vesicle cytoskeletal transport" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0030705", "GO:0051650" ]
[]
[]
[]
[ "GO:0030705", "GO:0051650" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099519
99,519
dense core granule cytoskeletal transport
biological_process
The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments.
[ "GOC:kmv", "PMID:23358451" ]
null
[ "dense core vesicle cytoskeletal trafficking" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0099518", "GO:1901950" ]
[ "occurs_in GO:0030424" ]
[ "occurs_in" ]
[ "GO:0030424" ]
[ "GO:0030424", "GO:0099518", "GO:1901950" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0099521
99,521
obsolete ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
molecular_function
OBSOLETE. Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
[ "GOC:dos", "PMID:17220883" ]
The reason for obsoletion is that this term is pre-composed and should be represented as a GO-CAM model.
[ "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential", "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0042625" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31205\" xsd:anyURI" ]
null
null
true
true
1
GO:0099522
99,522
cytosolic region
cellular_component
Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol.
[ "GOC:dos" ]
null
[ "region of cytosol" ]
[ "EXACT" ]
[]
[ "gocheck_do_not_annotate" ]
[]
[ "GO:0110165" ]
[ "part_of GO:0005829" ]
[ "part_of" ]
[ "GO:0005829" ]
[ "GO:0005829", "GO:0110165" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31276\" xsd:anyURI" ]
null
null
false
true
6
GO:0099523
99,523
presynaptic cytosol
cellular_component
The region of the cytosol consisting of all cytosol that is part of the presynapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005829" ]
[ "part_of GO:0005829", "part_of GO:0098793" ]
[ "part_of", "part_of" ]
[ "GO:0005829", "GO:0098793" ]
[ "GO:0005829", "GO:0098793" ]
[ "GO:0005829", "part_of GO:0005829", "part_of GO:0098793" ]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099524
99,524
postsynaptic cytosol
cellular_component
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005829" ]
[ "part_of GO:0005829", "part_of GO:0098794" ]
[ "part_of", "part_of" ]
[ "GO:0005829", "GO:0098794" ]
[ "GO:0005829", "GO:0098794" ]
[ "GO:0005829", "part_of GO:0005829", "part_of GO:0098794" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099525
99,525
presynaptic dense core vesicle exocytosis
biological_process
The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
[ "PMID:17553987", "PMID:24653208" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0048791", "GO:0099011" ]
[]
[]
[]
[ "GO:0048791", "GO:0099011" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099526
99,526
presynapse to nucleus signaling pathway
biological_process
The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
[ "GOC:dos", "PMID:24317321", "PMID:25652077" ]
This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
[ "presynaptic signaling to nucleus" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0098928" ]
[]
[]
[]
[ "GO:0098928" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0099527
99,527
postsynapse to nucleus signaling pathway
biological_process
The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
[ "GOC:dos", "PMID:24317321", "PMID:25652077" ]
null
[ "postsynaptic signaling to nucleus" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0098926" ]
[]
[]
[]
[ "GO:0098926" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099528
99,528
G protein-coupled neurotransmitter receptor activity
molecular_function
Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
[ "GOC:bf", "GOC:fj", "GOC:mah" ]
null
[ "G-protein coupled neurotransmitter receptor activity" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0004930", "GO:0030594" ]
[]
[]
[]
[ "GO:0004930", "GO:0030594" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0099529
99,529
obsolete neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
molecular_function
OBSOLETE. Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
[ "GOC:dos" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31330\" xsd:anyURI" ]
null
null
true
true
4
GO:0099530
99,530
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
molecular_function
A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
[ "GOC:dos" ]
null
[ "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0004930" ]
[ "occurs_in GO:0045211", "part_of GO:0060078" ]
[ "occurs_in", "part_of" ]
[ "GO:0045211", "GO:0060078" ]
[ "GO:0004930", "GO:0045211", "GO:0060078" ]
[ "GO:0004930", "part_of GO:0060078" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099531
99,531
obsolete presynaptic process involved in chemical synaptic transmission
biological_process
OBSOLETE. The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
[ "GOC:dos" ]
This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31306\" xsd:anyURI" ]
null
null
true
true
9
GO:0099532
99,532
synaptic vesicle endosomal processing
biological_process
The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
[ "GOC:aruk", "GOC:bc", "GOC:dos" ]
This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
[ "synaptic vesicle processing via endosome" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0016197" ]
[]
[]
[]
[ "GO:0016197" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0099533
99,533
positive regulation of presynaptic cytosolic calcium concentration
biological_process
Any process that increases the concentration of calcium ions in the presynaptic cytosol.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0007204" ]
[ "occurs_in GO:0098793" ]
[ "occurs_in" ]
[ "GO:0098793" ]
[ "GO:0007204", "GO:0098793" ]
[ "GO:0007204", "occurs_in GO:0098793" ]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099534
99,534
calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
molecular_function
The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
[ "PMID:24442513", "PMID:26190970" ]
null
[ "calcium ion binding involved in regulation of presynaptic cytosolic calcium levels", "presynaptic calcium ion buffering", "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0005509" ]
[ "occurs_in GO:0099523", "part_of GO:0099509" ]
[ "occurs_in", "part_of" ]
[ "GO:0099523", "GO:0099509" ]
[ "GO:0005509", "GO:0099509", "GO:0099523" ]
[ "GO:0005509", "part_of GO:0099509" ]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099535
99,535
synapse-associated extracellular matrix
cellular_component
The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
[ "GOC:dos" ]
null
[ "extra-synaptic extracellular matrix", "synapse-associated ECM" ]
[ "EXACT", "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0140047" ]
[]
[]
[]
[ "GO:0140047" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0099536
99,536
synaptic signaling
biological_process
Cell-cell signaling to, from or within a synapse.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_drosophila", "goslim_synapse" ]
[]
[ "GO:0007267" ]
[ "occurs_in GO:0045202" ]
[ "occurs_in" ]
[ "GO:0045202" ]
[ "GO:0007267", "GO:0045202" ]
[ "GO:0007267", "occurs_in GO:0045202" ]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0099537
99,537
trans-synaptic signaling
biological_process
Cell-cell signaling in either direction across the synaptic cleft.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099536" ]
[]
[]
[]
[ "GO:0099536" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0099538
99,538
synaptic signaling via neuropeptide
biological_process
Cell-cell signaling to or from a synapse, mediated by a peptide.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099536" ]
[]
[]
[]
[ "GO:0099536" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0099539
99,539
neuropeptide secretion from presynapse
biological_process
The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
[ "PMID:17553987", "PMID:24653208" ]
null
[ "neuropeptide secretion from presynapse via dense core granule exocytosis" ]
[ "EXACT" ]
[]
[ "goslim_synapse" ]
[]
[ "GO:0002790", "GO:0099525" ]
[ "part_of GO:0099538" ]
[ "part_of" ]
[ "GO:0099538" ]
[ "GO:0002790", "GO:0099525", "GO:0099538" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0099540
99,540
trans-synaptic signaling by neuropeptide
biological_process
Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099537", "GO:0099538" ]
[]
[]
[]
[ "GO:0099537", "GO:0099538" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0099541
99,541
trans-synaptic signaling by lipid
biological_process
Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099537" ]
[]
[]
[]
[ "GO:0099537" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0099542
99,542
trans-synaptic signaling by endocannabinoid
biological_process
Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099541" ]
[]
[]
[]
[ "GO:0099541" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0099543
99,543
trans-synaptic signaling by soluble gas
biological_process
Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099537" ]
[]
[]
[]
[ "GO:0099537" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0099545
99,545
trans-synaptic signaling by trans-synaptic complex
biological_process
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
[ "GOC:dos" ]
null
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0099537" ]
[]
[]
[]
[ "GO:0099537" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0099546
99,546
protein catabolic process, modulating synaptic transmission
biological_process
Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
[ "GOC:dos", "PMID:23083742" ]
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
[]
[]
[]
[ "goslim_synapse" ]
[]
[ "GO:0140246" ]
[ "regulates GO:0007268" ]
[ "regulates" ]
[ "GO:0007268" ]
[ "GO:0007268", "GO:0140246" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9