LiteFold/GO · Datasets at Hugging Face

GO:0006867

6,867

asparagine transport

biological_process

The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

[ "GOC:ai" ]

null

[ "L-asparagine transport" ]

[ "NARROW" ]

[]

[ "GO:0015804", "GO:0046942", "GO:0071705" ]

[]

[ "GO:0015804", "GO:0046942", "GO:0071705" ]

[]

null

false

true

4

GO:0006868

6,868

L-glutamine transport

biological_process

The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

[ "GOC:ai" ]

null

[ "glutamine transport" ]

[ "BROAD" ]

[ "GO:0015815" ]

[]

[ "GO:0015695", "GO:0015804", "GO:0015807" ]

[]

[ "GO:0015695", "GO:0015804", "GO:0015807" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27059\" xsd:anyURI" ]

null

false

true

5

GO:0006869

6,869

lipid transport

biological_process

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

[ "ISBN:0198506732" ]

null

[]

[ "goslim_drosophila", "goslim_pir", "goslim_yeast" ]

[ "Reactome:R-HSA-1369062 \"ABC transporters in lipid homeostasis\"" ]

[ "GO:0006810" ]

[ "part_of GO:0010876" ]

[ "part_of" ]

[ "GO:0010876" ]

[ "GO:0006810", "GO:0010876" ]

[]

null

false

true

3

GO:0006873

6,873

intracellular monoatomic ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.

[ "GOC:mah" ]

null

[ "cellular ion homeostasis", "cellular monoatomic ion homeostasis" ]

[ "BROAD", "EXACT" ]

[]

[ "goslim_yeast" ]

[]

[ "GO:0050801", "GO:0055082" ]

[]

[ "GO:0050801", "GO:0055082" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24455\" xsd:anyURI" ]

null

false

true

4

GO:0006874

6,874

intracellular calcium ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.

[ "GOC:ceb", "GOC:mah" ]

null

[ "cellular calcium ion homeostasis", "regulation of calcium ion concentration" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0030003", "GO:0055074" ]

[]

[ "GO:0030003", "GO:0055074" ]

[]

null

false

true

4

GO:0006875

6,875

obsolete intracellular metal ion homeostasis

biological_process

OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of metal ions within a cell.

[ "GOC:ai", "GOC:mah" ]

This term was obsoleted because it is an unnecessary grouping class.

[ "cellular heavy metal ion homeostasis", "cellular metal ion homeostasis" ]

[ "NARROW", "EXACT" ]

[]

[ "GO:0030003" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24570\" xsd:anyURI" ]

null

true

9

GO:0006876

6,876

obsolete intracellular cadmium ion homeostasis

biological_process

OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of cadmium ions within a cell.

[ "GOC:ai", "GOC:mah" ]

This term was obsoleted because it is not a normal process.

[ "cadmium homeostasis", "cellular cadmium ion homeostasis" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0098849" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24624\" xsd:anyURI" ]

null

true

9

GO:0006877

6,877

intracellular cobalt ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of cobalt (Co2+) ions within a cell.

[ "GOC:ai", "GOC:mah" ]

null

[ "cellular cobalt ion homeostasis", "cobalt homeostasis" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0030003", "GO:0098771" ]

[]

[ "GO:0030003", "GO:0098771" ]

[]

null

false

true

9

GO:0006878

6,878

intracellular copper ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.

[ "GOC:ai", "GOC:mah" ]

null

[ "cellular copper ion homeostasis", "copper homeostasis" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0030003", "GO:0055070" ]

[]

[ "GO:0030003", "GO:0055070" ]

[]

null

false

true

4

GO:0006879

6,879

intracellular iron ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.

[ "GOC:ai", "GOC:mah" ]

null

[ "cellular iron ion homeostasis", "iron homeostasis" ]

[ "EXACT", "BROAD" ]

[]

[ "Reactome:R-HSA-917937 \"Iron uptake and transport\"" ]

[ "GO:0030003", "GO:0098771" ]

[]

[ "GO:0030003", "GO:0098771" ]

[]

null

false

true

9

GO:0006880

6,880

obsolete intracellular sequestering of iron ion

biological_process

OBSOLETE. The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.

[ "GOC:ai" ]

The reason for obsoletion is that this term represents a molecular function, not a biological process.

[ "intracellular iron ion retention", "intracellular iron ion sequestering", "intracellular iron ion sequestration", "intracellular iron ion storage", "intracellular retention of iron ion", "intracellular sequestration of iron ion", "intracellular storage of iron ion" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0140315" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17075\" xsd:anyURI" ]

null

true

6

GO:0006881

6,881

obsolete extracellular sequestering of iron ion

biological_process

OBSOLETE. The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system.

[ "GOC:ai", "GOC:cjm" ]

The reason for obsoletion is that this term represents a molecular function, not a biological process.

[ "extracellular iron ion retention", "extracellular iron ion sequestering", "extracellular iron ion sequestration", "extracellular iron ion storage", "extracellular retention of iron ion", "extracellular sequestration of iron ion", "extracellular storage of iron ion" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0140315" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/17075\" xsd:anyURI" ]

null

true

4

GO:0006882

6,882

intracellular zinc ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell.

[ "GOC:ai", "GOC:mah" ]

null

[ "cellular zinc ion homeostasis", "zinc homeostasis" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0030003", "GO:0098771" ]

[]

[ "GO:0030003", "GO:0098771" ]

[]

null

false

true

4

GO:0006883

6,883

intracellular sodium ion homeostasis

biological_process

A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell.

[ "GOC:ai", "GOC:mah" ]

null

[ "cellular sodium ion homeostasis" ]

[ "EXACT" ]

[]

[ "GO:0030003", "GO:0055078" ]

[]

[ "GO:0030003", "GO:0055078" ]

[]

null

false

true

5

GO:0006884

6,884

cell volume homeostasis

biological_process

Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.

[ "GOC:curators", "GOC:dph", "GOC:tb" ]

null

[ "regulation of cell volume" ]

[ "EXACT" ]

[]

[ "GO:0008361", "GO:0019725" ]

[]

[ "GO:0008361", "GO:0019725" ]

[]

null

false

true

9

GO:0006885

6,885

regulation of pH

biological_process

Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.

[ "GOC:curators", "GOC:dph", "GOC:tb" ]

null

[ "hydrogen ion homeostasis" ]

[ "EXACT" ]

[]

[ "GO:0055080", "GO:0065007" ]

[]

[ "GO:0055080", "GO:0065007" ]

[]

null

false

true

1

GO:0006886

6,886

intracellular protein transport

biological_process

The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

[ "GOC:mah" ]

null

[ "copper-induced intracellular protein transport" ]

[ "RELATED" ]

[ "GO:0032779" ]

[ "goslim_generic", "goslim_prokaryote" ]

[]

[ "GO:0015031", "GO:0046907" ]

[ "part_of GO:0008104" ]

[ "part_of" ]

[ "GO:0008104" ]

[ "GO:0008104", "GO:0015031", "GO:0046907" ]

[]

null

false

true

3

GO:0006887

6,887

exocytosis

biological_process

A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formatio...

[ "GOC:mah", "ISBN:0716731363", "PMID:22323285" ]

null

[ "nonselective vesicle exocytosis", "vesicle exocytosis" ]

[ "RELATED", "EXACT" ]

[ "GO:0016194", "GO:0016195" ]

[ "goslim_yeast" ]

[ "Wikipedia:Exocytosis" ]

[ "GO:0016192", "GO:0032940" ]

[ "has_part GO:0099500" ]

[ "has_part" ]

[ "GO:0099500" ]

[ "GO:0016192", "GO:0032940", "GO:0099500" ]

[]

null

false

true

4

GO:0006888

6,888

endoplasmic reticulum to Golgi vesicle-mediated transport

biological_process

The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

[ "GOC:ascb_2009", "GOC:dph", "GOC:jp", "GOC:tb", "ISBN:0716731363" ]

null

[ "anterograde (ER to Golgi) transport", "anterograde transport, endoplasmic reticulum to Golgi", "anterograde transport, ER to Golgi", "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi", "anterograde vesicle-mediated transport, ER to Golgi", "endoplasmic reticulum to Golgi transport",...

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0048221" ]

[]

[ "Reactome:R-HSA-159763 \"Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus\"", "Reactome:R-HSA-199977 \"ER to Golgi Anterograde Transport\"" ]

[ "GO:0010496", "GO:0046907", "GO:0048193" ]

[ "occurs_in GO:0005737" ]

[ "occurs_in" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:0010496", "GO:0046907", "GO:0048193" ]

[]

null

false

true

6

GO:0006889

6,889

obsolete regulation of calcium in ER

biological_process

OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum.

[ "GOC:curators" ]

This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').

[ "regulation of calcium in ER" ]

[ "EXACT" ]

[]

[ "GO:0005783", "GO:0006874" ]

[]

null

true

6

GO:0006891

6,891

intra-Golgi vesicle-mediated transport

biological_process

The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).

[ "ISBN:0716731363" ]

null

[ "intra-Golgi transport" ]

[ "EXACT" ]

[]

[ "GO:0048193" ]

[]

[ "GO:0048193" ]

[]

null

false

true

4

GO:0006893

6,893

Golgi to plasma membrane transport

biological_process

The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. Golgi to plasma membrane transport precedes exocytosis.

[ "ISBN:0716731363" ]

null

[ "Golgi to plasma membrane vesicle-mediated transport" ]

[ "EXACT" ]

[]

[ "GO:0006892", "GO:0098876" ]

[]

[ "GO:0006892", "GO:0098876" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31197\" xsd:anyURI" ]

null

false

true

5

GO:0006894

6,894

obsolete Golgi to secretory vesicle transport

biological_process

OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble ...

[ "ISBN:0716731363" ]

This term was made obsolete because it mixes two processes that can be better captured in separate terms.

[ "Golgi to secretory vesicle transport", "Golgi to secretory vesicle transport, vesicle-mediated" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0006893", "GO:0055107" ]

[]

null

true

5

GO:0006895

6,895

Golgi to endosome transport

biological_process

The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.

[ "GOC:jl", "ISBN:0716731363", "PMID:10873832" ]

null

[ "Golgi to endosome vesicle-mediated transport", "TGN to endosome transport", "trans-Golgi to endosome transport" ]

[ "EXACT", "EXACT", "EXACT" ]

[ "GO:0048218" ]

[]

[ "GO:0006892", "GO:0010496", "GO:0016482" ]

[]

[ "GO:0006892", "GO:0010496", "GO:0016482" ]

[]

null

false

true

6

GO:0006896

6,896

Golgi to vacuole transport

biological_process

The directed movement of substances from the Golgi to the vacuole.

[ "GOC:ai" ]

null

[ "Golgi to vacuole vesicle-mediated transport" ]

[ "EXACT" ]

[]

[ "GO:0006892", "GO:0007034", "GO:0010496" ]

[]

[ "GO:0006892", "GO:0007034", "GO:0010496" ]

[]

null

false

true

4

GO:0006897

6,897

endocytosis

biological_process

A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.

[ "GOC:mah", "ISBN:0198506732", "ISBN:0716731363", "Wikipedia:Endocytosis" ]

null

[ "endocytic import into cell", "nonselective vesicle endocytosis", "plasma membrane invagination", "vesicle endocytosis" ]

[ "EXACT", "RELATED", "NARROW", "EXACT" ]

[ "GO:0016193", "GO:0016196", "GO:0098701" ]

[ "goslim_yeast" ]

[ "Wikipedia:Endocytosis" ]

[ "GO:0016192", "GO:0098657" ]

[ "has_part GO:0006900", "has_part GO:0010324" ]

[ "has_part", "has_part" ]

[ "GO:0006900", "GO:0010324" ]

[ "GO:0006900", "GO:0010324", "GO:0016192", "GO:0098657" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24907\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25268\" xsd:anyURI" ]

null

false

true

8

GO:0006898

6,898

receptor-mediated endocytosis

biological_process

An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transp...

[ "GOC:mah", "ISBN:0716731363" ]

null

[ "receptor mediated endocytosis" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-2173782 \"Binding and Uptake of Ligands by Scavenger Receptors\"", "Wikipedia:Receptor-mediated_endocytosis" ]

[ "GO:0006897" ]

[]

[ "GO:0006897" ]

[]

null

false

true

5

GO:0006900

6,900

vesicle budding from membrane

biological_process

The evagination of a membrane, resulting in formation of a vesicle.

[ "GOC:jid", "GOC:tb" ]

null

[ "membrane evagination", "nonselective vesicle assembly", "single organism membrane budding", "single-organism membrane budding", "vesicle biosynthesis", "vesicle budding", "vesicle formation" ]

[ "EXACT", "RELATED", "RELATED", "RELATED", "EXACT", "RELATED", "EXACT" ]

[ "GO:0006902", "GO:1902591" ]

[]

[ "GO:0016050", "GO:0061024" ]

[ "part_of GO:0016192" ]

[ "part_of" ]

[ "GO:0016192" ]

[ "GO:0016050", "GO:0016192", "GO:0061024" ]

[]

jl

2013-12-19T15:26:17Z

false

true

8

GO:0006901

6,901

vesicle coating

biological_process

A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.

[ "GOC:jid" ]

null

[ "vesicle coat assembly" ]

[ "BROAD" ]

[]

[ "GO:0016050" ]

[ "part_of GO:0006900" ]

[ "part_of" ]

[ "GO:0006900" ]

[ "GO:0006900", "GO:0016050" ]

[]

null

false

true

1

GO:0006903

6,903

vesicle targeting

biological_process

The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.

[ "GOC:mah", "PMID:17335816" ]

null

[]

[ "GO:0009987" ]

[ "part_of GO:0016192", "part_of GO:0051650" ]

[ "part_of", "part_of" ]

[ "GO:0016192", "GO:0051650" ]

[ "GO:0009987", "GO:0016192", "GO:0051650" ]

[]

null

false

true

6

GO:0006904

6,904

vesicle docking involved in exocytosis

biological_process

The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.

[ "GOC:aruk", "GOC:bc", "GOC:jid", "PMID:22438915" ]

null

[ "vesicle docking during exocytosis" ]

[ "RELATED" ]

[]

[ "GO:0048278", "GO:0140029" ]

[]

[ "GO:0048278", "GO:0140029" ]

[ "GO:0048278", "part_of GO:0006887" ]

[]

null

false

true

3

GO:0006906

6,906

vesicle fusion

biological_process

Fusion of the membrane of a transport vesicle with its target membrane.

[ "GOC:jid" ]

null

[]

[ "GO:0016050", "GO:0090174" ]

[ "part_of GO:0016192" ]

[ "part_of" ]

[ "GO:0016192" ]

[ "GO:0016050", "GO:0016192", "GO:0090174" ]

[]

null

false

true

7

GO:0006907

6,907

pinocytosis

biological_process

An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane.

[ "ISBN:0198506732" ]

null

[ "clathrin-independent pinocytosis", "fluid-phase endocytosis", "single-organism pinocytosis" ]

[ "BROAD", "EXACT", "RELATED" ]

[ "GO:0006908", "GO:1902536" ]

[]

[ "Wikipedia:Pinocytosis" ]

[ "GO:0006897" ]

[]

[ "GO:0006897" ]

[]

jl

2013-12-02T14:14:38Z

false

true

1

GO:0006909

6,909

phagocytosis

biological_process

A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.

[ "ISBN:0198506732" ]

null

[]

[ "Reactome:R-HSA-9664417 \"Leishmania phagocytosis\"", "Wikipedia:Phagocytosis" ]

[ "GO:0006897" ]

[]

[ "GO:0006897" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24907\" xsd:anyURI" ]

null

false

true

6

GO:0006910

6,910

phagocytosis, recognition

biological_process

The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to ...

[ "GOC:curators", "ISBN:0781735149" ]

Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to...

[ "recognition of phagocytosed substance by phagocytic cell" ]

[ "EXACT" ]

[]

[ "GO:0008037" ]

[ "has_part GO:0038024", "part_of GO:0006909" ]

[ "has_part", "part_of" ]

[ "GO:0038024", "GO:0006909" ]

[ "GO:0006909", "GO:0008037", "GO:0038024" ]

[ "GO:0008037", "part_of GO:0006909" ]

[]

null

false

true

9

GO:0006911

6,911

phagocytosis, engulfment

biological_process

The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the ta...

[ "GOC:curators", "ISBN:0781735149" ]

null

[ "phagosome biosynthesis", "phagosome formation" ]

[ "RELATED", "RELATED" ]

[]

[ "GO:0099024" ]

[ "part_of GO:0006909" ]

[ "part_of" ]

[ "GO:0006909" ]

[ "GO:0006909", "GO:0099024" ]

[ "GO:0099024", "part_of GO:0006909" ]

[]

null

false

true

3

GO:0006912

6,912

obsolete phagosome formation

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:hjd" ]

This term was made obsolete because of the ambiguity in its meaning.

[ "phagosome formation" ]

[ "EXACT" ]

[]

[ "GO:0001845", "GO:0006911" ]

[]

null

true

3

GO:0006913

6,913

nucleocytoplasmic transport

biological_process

The directed movement of molecules between the nucleus and the cytoplasm.

[ "GOC:curators" ]

Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.

[ "nucleocytoplasmic shuttling" ]

[ "NARROW" ]

[ "GO:0000063" ]

[ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pombe" ]

[]

[ "GO:0051169" ]

[]

[ "GO:0051169" ]

[]

null

false

true

2

GO:0006914

6,914

autophagy

biological_process

The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during ce...

[ "GOC:autophagy", "ISBN:0198547684", "PMID:11099404", "PMID:29455577", "PMID:9412464" ]

null

[]

[ "GO:0016238" ]

[ "goslim_chembl", "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_pir", "goslim_pombe" ]

[ "Reactome:R-HSA-9612973 \"Autophagy\"", "Wikipedia:Autophagy_(cellular)" ]

[ "GO:0009056", "GO:0061919" ]

[ "has_part GO:0055085" ]

[ "has_part" ]

[ "GO:0055085" ]

[ "GO:0009056", "GO:0055085", "GO:0061919" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25541\" xsd:anyURI" ]

null

false

true

3

GO:0006918

6,918

obsolete induction of apoptosis by p53

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete because more accurate terms were created.

[ "induction of apoptosis by p53" ]

[ "EXACT" ]

[]

[ "GO:0006915" ]

[]

null

true

4

GO:0006919

6,919

obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process

biological_process

OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

[ "GOC:al", "GOC:dph", "GOC:jl", "GOC:mtg_apoptosis", "GOC:tb", "PMID:14744432", "PMID:18328827", "Wikipedia:Caspase" ]

This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use th...

[ "activation of caspase activity", "activation of metacaspase activity", "caspase activation" ]

[ "NARROW", "NARROW", "EXACT" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28468\" xsd:anyURI" ]

null

true

5

GO:0006920

6,920

obsolete commitment to apoptosis

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete because more accurate terms were created.

[ "commitment to apoptosis" ]

[ "EXACT" ]

[]

[ "GO:0006915" ]

[]

null

true

8

GO:0006921

6,921

cellular component disassembly involved in execution phase of apoptosis

biological_process

The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.

[ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb" ]

null

[ "cellular component disassembly involved in apoptosis", "cellular component disassembly involved in apoptotic process", "disassembly of cell structures" ]

[ "NARROW", "BROAD", "BROAD" ]

[]

[ "GO:0022411" ]

[ "part_of GO:0097194" ]

[ "part_of" ]

[ "GO:0097194" ]

[ "GO:0022411", "GO:0097194" ]

[ "GO:0022411", "part_of GO:0097194" ]

[]

null

false

true

5

GO:0006922

6,922

obsolete cleavage of lamin involved in execution phase of apoptosis

biological_process

OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina.

[ "GOC:mah", "GOC:mtg_apoptosis", "ISBN:0815332181" ]

This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.

[ "cleavage of lamin", "cleavage of lamin involved in execution phase of apoptosis" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

9

GO:0006923

6,923

obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis

biological_process

OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures.

[ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0815332181" ]

This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'.

[ "apoptotic cleavage of cytoskeletal proteins", "cleavage of cytoskeletal proteins involved in apoptosis", "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" ]

[ "EXACT", "BROAD", "EXACT" ]

[]

[ "GO:0004197" ]

[]

null

true

2

GO:0006924

6,924

activation-induced cell death of T cells

biological_process

A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p5...

[ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196", "PMID:12414721", "PMID:12752672" ]

null

[ "activated T cell apoptosis", "activation-induced cell death of T lymphocytes", "activation-induced cell death of T-cells", "activation-induced cell death of T-lymphocytes", "AICD", "antigen-driven apoptosis" ]

[ "BROAD", "EXACT", "EXACT", "EXACT", "BROAD", "BROAD" ]

[]

[ "GO:0070231" ]

[ "part_of GO:0043029" ]

[ "part_of" ]

[ "GO:0043029" ]

[ "GO:0043029", "GO:0070231" ]

[]

null

false

true

3

GO:0006925

6,925

inflammatory cell apoptotic process

biological_process

Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.

[ "GOC:jl", "GOC:mtg_apoptosis" ]

null

[ "apoptosis of inflammatory cells", "inflammatory cell apoptosis", "inflammatory cell programmed cell death by apoptosis", "killing of inflammatory cells", "programmed cell death of inflammatory cells by apoptosis", "programmed cell death, inflammatory cells" ]

[ "EXACT", "NARROW", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-168277 \"Influenza Virus Induced Apoptosis\"" ]

[ "GO:0006915" ]

[]

[ "GO:0006915" ]

[]

null

false

true

6

GO:0006926

6,926

obsolete virus-infected cell apoptotic process

biological_process

OBSOLETE. Any apoptotic process in a cell infected with a virus.

[ "GOC:jl", "GOC:mtg_apoptosis" ]

This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral...

[ "apoptosis of virus-infected cells", "killing virus-infected cells", "programmed cell death of virus-infected cells by apoptosis", "programmed cell death, virus-infected cells", "virus-infected cell apoptosis", "virus-infected cell apoptotic process", "virus-infected cell programmed cell death by apopto...

[ "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT" ]

[]

null

true

9

GO:0006927

6,927

obsolete transformed cell apoptotic process

biological_process

OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm.

[ "GOC:jl", "GOC:mtg_apoptosis" ]

This term was made obsolete because it does not refer to a normal process.

[ "apoptosis of transformed cells", "killing transformed cells", "programmed cell death of transformed cells by apoptosis", "programmed cell death, transformed cells", "transformed cell apoptosis", "transformed cell programmed cell death by apoptosis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "NARROW", "EXACT" ]

[]

null

true

7

GO:0006930

6,930

substrate-dependent cell migration, cell extension

biological_process

The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.

[ "ISBN:0815316194", "PMID:11944043", "PMID:14657486" ]

null

[ "substrate-bound cell migration, cell extension" ]

[ "EXACT" ]

[]

[ "GO:0120031" ]

[ "part_of GO:0006929" ]

[ "part_of" ]

[ "GO:0006929" ]

[ "GO:0006929", "GO:0120031" ]

[]

null

false

true

9

GO:0006931

6,931

substrate-dependent cell migration, cell attachment to substrate

biological_process

The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions.

[ "ISBN:0815316194", "PMID:11944043", "PMID:14657486" ]

null

[ "substrate-bound cell migration, cell attachment to substrate" ]

[ "EXACT" ]

[]

[ "GO:0031589" ]

[ "part_of GO:0006929" ]

[ "part_of" ]

[ "GO:0006929" ]

[ "GO:0006929", "GO:0031589" ]

[]

null

false

true

3

GO:0006932

6,932

substrate-dependent cell migration, cell contraction

biological_process

The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves.

[ "ISBN:0815316194", "PMID:11944043", "PMID:14657486" ]

null

[ "substrate-bound cell migration, cell contraction" ]

[ "EXACT" ]

[]

[ "GO:0060327" ]

[ "part_of GO:0001667", "part_of GO:0006929" ]

[ "part_of", "part_of" ]

[ "GO:0001667", "GO:0006929" ]

[ "GO:0001667", "GO:0006929", "GO:0060327" ]

[]

null

false

true

6

GO:0006934

6,934

substrate-bound cell migration, adhesion receptor recycling

biological_process

The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions.

[ "PMID:11944043" ]

null

[]

[ "GO:0001881" ]

[ "part_of GO:0006933" ]

[ "part_of" ]

[ "GO:0006933" ]

[ "GO:0001881", "GO:0006933" ]

[]

null

false

true

5

GO:0006935

6,935

chemotaxis

biological_process

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

[ "ISBN:0198506732" ]

null

[ "taxis in response to chemical stimulus" ]

[ "EXACT" ]

[]

[ "Wikipedia:Chemotaxis" ]

[ "GO:0042330" ]

[ "part_of GO:0042221" ]

[ "part_of" ]

[ "GO:0042221" ]

[ "GO:0042221", "GO:0042330" ]

[]

null

false

true

4

GO:0006936

6,936

muscle contraction

biological_process

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

[ "GOC:ef", "GOC:mtg_muscle", "ISBN:0198506732" ]

null

[]

[ "goslim_pir" ]

[ "Reactome:R-HSA-445355 \"Smooth Muscle Contraction\"", "Wikipedia:Muscle_contraction" ]

[ "GO:0003012" ]

[]

[ "GO:0003012" ]

[]

null

false

true

6

GO:0006937

6,937

regulation of muscle contraction

biological_process

Any process that modulates the frequency, rate or extent of muscle contraction.

[ "GOC:curators" ]

null

[]

[ "GO:0090257" ]

[ "regulates GO:0006936" ]

[ "regulates" ]

[ "GO:0006936" ]

[ "GO:0006936", "GO:0090257" ]

[ "GO:0065007", "regulates GO:0006936" ]

[]

null

false

true

6

GO:0006939

6,939

smooth muscle contraction

biological_process

A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated mus...

[ "GOC:ef", "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ]

null

[ "visceral muscle contraction" ]

[ "EXACT" ]

[]

[ "GO:0006936" ]

[]

[ "GO:0006936" ]

[]

null

false

true

2

GO:0006940

6,940

regulation of smooth muscle contraction

biological_process

Any process that modulates the frequency, rate or extent of smooth muscle contraction.

[ "GOC:curators" ]

null

[]

[ "GO:0006937" ]

[ "regulates GO:0006939" ]

[ "regulates" ]

[ "GO:0006939" ]

[ "GO:0006937", "GO:0006939" ]

[ "GO:0065007", "regulates GO:0006939" ]

[]

null

false

true

1

GO:0006941

6,941

striated muscle contraction

biological_process

A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle ...

[ "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ]

null

[ "sarcomeric muscle contraction" ]

[ "EXACT" ]

[]

[ "GO:0006936" ]

[]

[ "GO:0006936" ]

[]

null

false

true

6

GO:0006945

6,945

obsolete nuclear fusion during karyogamy

biological_process

OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process.

[ "PMID:9442101" ]

This term was made obsolete because it is redundant outside the context of Saccharomyces biology.

[ "nuclear fusion during karyogamy" ]

[ "EXACT" ]

[]

[ "GO:0000741" ]

[]

null

true

9

GO:0006948

6,948

obsolete induction by virus of host cell-cell fusion

biological_process

OBSOLETE. The process of syncytia-forming cell-cell fusion, caused by a virus.

[ "ISBN:0781718325" ]

This term was obsoleted because it represents the same process as positive regulation of syncytium formation by virus ; GO:0060141.

[ "induction by virus of cell-cell fusion in host", "viral-induced cell-cell fusion", "viral-induced host cell-cell fusion", "viral-induced membrane fusion" ]

[ "EXACT", "EXACT", "EXACT", "NARROW" ]

[]

[ "GO:0060141" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28984\" xsd:anyURI" ]

null

true

7

GO:0006949

6,949

obsolete syncytium formation

biological_process

OBSOLETE. The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.

[ "ISBN:0198506732" ]

The reason for obsoletion is that this term was an unnecessary grouping term.

[]

[ "GO:0000768" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31270\" xsd:anyURI" ]

null

true

3

GO:0006950

6,950

response to stress

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

[ "GOC:mah" ]

null

[ "response to abiotic stress", "response to biotic stress" ]

[ "RELATED", "RELATED" ]

[]

[ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_metagenomics", "goslim_plant", "goslim_plant_ribbon" ]

[]

[ "GO:0050896" ]

[]

[ "GO:0050896" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26810\" xsd:anyURI" ]

null

false

true

8

GO:0006952

6,952

defense response

biological_process

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

[ "GOC:curators" ]

null

[ "antimicrobial peptide activity", "defence response", "defense/immunity protein activity", "physiological defense response" ]

[ "RELATED", "EXACT", "RELATED", "EXACT" ]

[ "GO:0002217", "GO:0042829" ]

[]

[ "GO:0006950" ]

[]

[ "GO:0006950" ]

[]

null

false

true

4

GO:0006953

6,953

acute-phase response

biological_process

An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

[ "ISBN:0198506732" ]

null

[]

[ "GO:0002526" ]

[]

[ "GO:0002526" ]

[]

null

false

true

5

GO:0006954

6,954

inflammatory response

biological_process

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

[ "GO_REF:0000022", "ISBN:0198506732" ]

null

[ "inflammation" ]

[ "BROAD" ]

[]

[ "goslim_generic" ]

[ "Wikipedia:Inflammation" ]

[ "GO:0006952" ]

[]

[ "GO:0006952" ]

[]

null

false

true

8

GO:0006955

6,955

immune response

biological_process

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

[ "GO_REF:0000022", "GOC:add" ]

null

[]

[ "goslim_drosophila" ]

[]

[ "GO:0002376", "GO:0050896" ]

[]

[ "GO:0002376", "GO:0050896" ]

[]

null

false

true

8

GO:0006956

6,956

complement activation

biological_process

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alte...

[ "GO_REF:0000022", "GOC:add", "ISBN:0781735149" ]

null

[ "complement activity", "complement cascade", "complement response" ]

[ "RELATED", "EXACT", "EXACT" ]

[]

[ "Reactome:R-HSA-166658 \"Complement cascade\"" ]

[ "GO:0002252", "GO:0002253", "GO:0006959" ]

[ "has_part GO:0072376" ]

[ "has_part" ]

[ "GO:0072376" ]

[ "GO:0002252", "GO:0002253", "GO:0006959", "GO:0072376" ]

[]

null

false

true

9

GO:0006957

6,957

complement activation, alternative pathway

biological_process

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

[ "GOC:add", "ISBN:0781735149" ]

null

[ "complement cascade, alternative pathway" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-173736 \"Alternative complement activation\"" ]

[ "GO:0006956", "GO:0045087" ]

[]

[ "GO:0006956", "GO:0045087" ]

[]

null

false

true

4

GO:0006958

6,958

complement activation, classical pathway

biological_process

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

[ "GOC:add", "ISBN:0781735149" ]

null

[ "complement cascade, classical pathway" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-173623 \"Classical antibody-mediated complement activation\"" ]

[ "GO:0006956" ]

[ "part_of GO:0002455" ]

[ "part_of" ]

[ "GO:0002455" ]

[ "GO:0002455", "GO:0006956" ]

[]

null

false

true

8

GO:0006959

6,959

humoral immune response

biological_process

An immune response mediated through a body fluid.

[ "GOC:hb", "ISBN:0198506732" ]

null

[]

[ "Wikipedia:Humoral_immunity" ]

[ "GO:0006955" ]

[]

[ "GO:0006955" ]

[]

null

false

true

7

GO:0006962

6,962

male-specific antibacterial humoral response

biological_process

An immune response against bacteria, specific to males and mediated through a body fluid.

[ "GOC:curators" ]

null

[]

[ "GO:0019731", "GO:0050831" ]

[]

[ "GO:0019731", "GO:0050831" ]

[]

null

false

true

3

GO:0006963

6,963

positive regulation of antibacterial peptide biosynthetic process

biological_process

Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.

[ "GOC:mah", "PMID:10973475" ]

null

[ "activation of antibacterial peptide biosynthetic process", "antibacterial peptide induction", "antibacterial polypeptide induction", "stimulation of antibacterial peptide biosynthetic process", "up regulation of antibacterial peptide biosynthetic process", "up-regulation of antibacterial peptide biosynth...

[ "NARROW", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0002803", "GO:0002807", "GO:0002808" ]

[ "positively_regulates GO:0002780" ]

[ "positively_regulates" ]

[ "GO:0002780" ]

[ "GO:0002780", "GO:0002803", "GO:0002807", "GO:0002808" ]

[ "GO:0065007", "positively_regulates GO:0002780" ]

[]

null

false

true

2

GO:0006964

6,964

positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

biological_process

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.

[ "GOC:mah", "PMID:10973475" ]

null

[ "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "anti-Gram-negative bacterial peptide induction", "anti-Gram-negative bacterial polypeptide induction", "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", ...

[ "NARROW", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0002813", "GO:0006963" ]

[ "positively_regulates GO:0002812" ]

[ "positively_regulates" ]

[ "GO:0002812" ]

[ "GO:0002812", "GO:0002813", "GO:0006963" ]

[ "GO:0065007", "positively_regulates GO:0002812" ]

[]

null

false

true

8

GO:0006965

6,965

positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

biological_process

Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.

[ "GOC:mah", "PMID:10973475" ]

null

[ "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", "anti-Gram-positive bacterial peptide induction", "anti-Gram-positive bacterial polypeptide induction", "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria", ...

[ "NARROW", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0002816", "GO:0006963" ]

[ "positively_regulates GO:0002815" ]

[ "positively_regulates" ]

[ "GO:0002815" ]

[ "GO:0002815", "GO:0002816", "GO:0006963" ]

[ "GO:0065007", "positively_regulates GO:0002815" ]

[]

null

false

true

6

GO:0006967

6,967

positive regulation of antifungal peptide biosynthetic process

biological_process

Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis.

[ "GOC:mah" ]

null

[ "activation of antifungal peptide biosynthetic process", "antifungal peptide induction", "antifungal polypeptide induction", "stimulation of antifungal peptide biosynthetic process", "up regulation of antifungal peptide biosynthetic process", "up-regulation of antifungal peptide biosynthetic process", "...

[ "NARROW", "EXACT", "EXACT", "NARROW", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0002804", "GO:0002807", "GO:0002810" ]

[ "positively_regulates GO:0002783" ]

[ "positively_regulates" ]

[ "GO:0002783" ]

[ "GO:0002783", "GO:0002804", "GO:0002807", "GO:0002810" ]

[ "GO:0065007", "positively_regulates GO:0002783" ]

[]

null

false

true

5

GO:0006968

6,968

cellular defense response

biological_process

A defense response that is mediated by cells.

[ "GOC:ebc" ]

null

[ "cellular defence response", "intracellular defence response", "intracellular defense response" ]

[ "EXACT", "NARROW", "NARROW" ]

[ "GO:0002818", "GO:0016066", "GO:0016067" ]

[]

[ "GO:0006952" ]

[]

[ "GO:0006952" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/18111\" xsd:anyURI" ]

null

false

true

8

GO:0006969

6,969

obsolete melanotic tumor response

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:add" ]

This term was made obsolete because it was undefined and represented an abnormal process.

[ "melanotic mass response", "melanotic tumor response" ]

[ "EXACT", "EXACT" ]

[]

null

true

5

GO:0006970

6,970

response to osmotic stress

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

[ "GOC:jl" ]

null

[ "osmotic response", "osmotic stress response" ]

[ "EXACT", "EXACT" ]

[]

[ "goslim_yeast" ]

[]

[ "GO:0006950", "GO:0009628" ]

[]

[ "GO:0006950", "GO:0009628" ]

[]

null

false

true

1

GO:0006971

6,971

hypotonic response

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.

[ "GOC:jl", "PMID:12598593" ]

null

[ "hypo-osmotic response" ]

[ "EXACT" ]

[]

[ "GO:0006970" ]

[]

[ "GO:0006970" ]

[]

null

false

true

7

GO:0006972

6,972

hyperosmotic response

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.

[ "GOC:jl", "PMID:12142009" ]

null

[ "HOG response", "hypertonic response", "response to hypertonicity" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0006970" ]

[]

[ "GO:0006970" ]

[]

null

false

true

3

GO:0006973

6,973

intracellular accumulation of glycerol

biological_process

The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment.

[ "GOC:jl", "PMID:11752666" ]

null

[]

[ "GO:0019725" ]

[ "part_of GO:0071474" ]

[ "part_of" ]

[ "GO:0071474" ]

[ "GO:0019725", "GO:0071474" ]

[]

null

false

true

4

GO:0006974

6,974

DNA damage response

biological_process

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

[ "GOC:curators" ]

null

[ "cellular DNA damage response", "cellular response to DNA damage stimulus", "response to DNA damage stimulus", "response to genotoxic stress" ]

[ "EXACT", "EXACT", "BROAD", "EXACT" ]

[ "GO:0034984" ]

[ "goslim_yeast" ]

[]

[ "GO:0033554" ]

[]

[ "GO:0033554" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24775\" xsd:anyURI" ]

null

false

true

6

GO:0006977

6,977

obsolete DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

biological_process

OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

[ "GOC:curators" ]

The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.

[ "positive regulation of cell cycle arrest by p53-mediated DNA damage response" ]

[ "EXACT" ]

[]

[ "GO:0030330" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26003\" xsd:anyURI" ]

null

true

5

GO:0006978

6,978

obsolete DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

biological_process

OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.

[ "PMID:10967424" ]

The reason for obsoletion is that this term is about down stream effects, not the signaling pathway itself.

[]

[ "GO:0030330" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26003\" xsd:anyURI" ]

null

true

1

GO:0006979

6,979

response to oxidative stress

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2...

[ "GOC:jl", "PMID:12115731" ]

null

[]

[ "goslim_yeast" ]

[]

[ "GO:0006950" ]

[]

[ "GO:0006950" ]

[]

null

false

true

3

GO:0006981

6,981

obsolete activation of SoxR protein

biological_process

OBSOLETE. The conversion of the SoxR transcription factor to its active (oxidized) form.

[ "GOC:jl", "PMID:8816757" ]

This term was made obsolete because it was too specific with respect to a single gene product.

[]

null

true

6

GO:0006983

6,983

ER overload response

biological_process

The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.

[ "PMID:10390516" ]

null

[ "endoplasmic reticulum overload response", "EOR", "EOR-mediated activation of NF-kappaB", "EOR-mediated NF-kappaB activation", "ER-overload response", "positive regulation of NF-kappaB transcription factor activity by EOR", "positive regulation of NF-kappaB transcription factor activity by ER overload r...

[ "EXACT", "EXACT", "NARROW", "NARROW", "EXACT", "NARROW", "NARROW" ]

[ "GO:0006985" ]

[]

[ "GO:0006984", "GO:0034976", "GO:0071216" ]

[]

[ "GO:0006984", "GO:0034976", "GO:0071216" ]

[]

null

false

true

3

GO:0006984

6,984

ER-nucleus signaling pathway

biological_process

The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.

[ "GOC:mah" ]

null

[ "endoplasmic reticulum to nucleus signaling pathway", "endoplasmic reticulum-nuclear signaling pathway", "ER to nucleus signaling pathway", "ER to nucleus signalling pathway", "ER-nuclear signaling pathway", "ER-nuclear signalling pathway" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0035556" ]

[]

[ "GO:0035556" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28057\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28069\" xsd:anyURI" ]

null

false

true

2

GO:0006986

6,986

response to unfolded protein

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

[ "GOC:jl" ]

Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.

[ "heat shock protein activity" ]

[ "RELATED" ]

[]

[ "GO:0035966" ]

[]

[ "GO:0035966" ]

[]

null

false

true

4

GO:0006987

6,987

obsolete activation of signaling protein activity involved in unfolded protein response

biological_process

OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response.

[ "GOC:dph", "GOC:mah", "GOC:tb", "PMID:12042763" ]

The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498).

[ "unfolded protein response, activation of signaling protein activity", "unfolded protein response, activation of signaling protein kinase/endonuclease", "unfolded protein response, activation of signalling protein kinase/endonuclease" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0036498" ]

[]

null

true

6

GO:0006988

6,988

obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a function rather than a process.

[ "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" ]

[ "EXACT" ]

[]

[ "GO:0004521" ]

[]

null

true

4

GO:0006989

6,989

obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase

biological_process

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:mah" ]

This term was made obsolete because it represents a function rather than a process.

[ "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" ]

[ "EXACT" ]

[]

[ "GO:0008452" ]

[]

null

true

2

GO:0006990

6,990

obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

biological_process

OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response.

[ "GOC:dph", "GOC:mah", "GOC:tb", "GOC:txnOH", "PMID:12042763" ]

This term was obsoleted because is represents a GO-CAM model.

[ "positive regulation of transcription of target genes involved in unfolded protein response", "unfolded protein response, activation of target gene transcription", "unfolded protein response, positive regulation of target gene transcription", "unfolded protein response, stimulation of target gene transcriptio...

[ "EXACT", "NARROW", "EXACT", "NARROW", "BROAD", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0030968", "GO:0034514", "GO:0045944" ]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12739\" xsd:anyURI" ]

null

true

3

GO:0006991

6,991

response to sterol depletion

biological_process

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a h...

[ "GOC:bf", "ISBN:0198506732" ]

null

[ "sterol depletion response" ]

[ "EXACT" ]

[]

[ "GO:0006950" ]

[]

[ "GO:0006950" ]

[]

null

false

true

2

GO:0006995

6,995

cellular response to nitrogen starvation

biological_process

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.

[ "GOC:jl" ]

null

[]

[ "GO:0009267", "GO:0043562" ]

[]

[ "GO:0009267", "GO:0043562" ]

[]

null

false

true

4

GO:0006996

6,996

organelle organization

biological_process

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes an...

[ "GOC:mah" ]

Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

[ "organelle organisation", "organelle organization and biogenesis", "single organism organelle organization", "single-organism organelle organization" ]

[ "EXACT", "RELATED", "EXACT", "RELATED" ]

[ "GO:1902589" ]

[ "gocheck_do_not_annotate", "goslim_candida", "goslim_pir" ]

[ "Reactome:R-HSA-1852241 \"Organelle biogenesis and maintenance\"" ]

[ "GO:0016043" ]

[]

[ "GO:0016043" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27189\" xsd:anyURI" ]

jl

2013-12-19T15:25:51Z

false

true

6

GO:0006997

6,997

nucleus organization

biological_process

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.

[ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ]

null

[ "nuclear morphology", "nuclear organisation", "nuclear organization", "nuclear organization and biogenesis", "nucleus organization and biogenesis" ]

[ "RELATED", "EXACT", "EXACT", "RELATED", "RELATED" ]

[ "GO:0048287" ]

[ "goslim_candida", "goslim_drosophila", "goslim_pir", "goslim_yeast" ]

[]

[ "GO:0006996" ]

[]

[ "GO:0006996" ]

[]

null

false

true

7

GO:0006998

6,998

nuclear envelope organization

biological_process

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.

[ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ]

null

[ "nuclear envelope organisation", "nuclear envelope organization and biogenesis" ]

[ "EXACT", "RELATED" ]

[]

[ "GO:0061024" ]

[ "part_of GO:0006997", "part_of GO:0010256" ]

[ "part_of", "part_of" ]

[ "GO:0006997", "GO:0010256" ]

[ "GO:0006997", "GO:0010256", "GO:0061024" ]

[]

null

false

true

9

GO:0006999

6,999

nuclear pore organization

biological_process

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore.

[ "GOC:dph", "GOC:jid", "GOC:jl", "GOC:mah" ]

null

[ "nuclear pore complex organization and biogenesis", "nuclear pore organisation", "nuclear pore organization and biogenesis" ]

[ "RELATED", "EXACT", "RELATED" ]

[]

[ "GO:0006997", "GO:0043933" ]

[]

[ "GO:0006997", "GO:0043933" ]

[]

null

false

true

8