interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052176 | 52,176 | Glycosyl Hydrolase Family 43 Enzymes | Glycosyl_Hydrlase_43_Enz | Family | 15,024 | true | false | The glycosyl hydrolase 43 family encompasses enzymes with diverse functions related to the degradation of plant cell wall components. Members of this family are involved in the hydrolysis of glycosidic bonds in beta-galactofuranoside-containing glycans, arabinoxylans, and xylooligosaccharides. They exhibit activities s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43772"
] | [
"Glycosyl_Hydrlase_43_Enz"
] | [
15024
] | 1 | [
"EC"
] | [
"3.2.1.55"
] | [
"EC:3.2.1.55"
] | 1 | [
"3c7e",
"3c7f",
"3c7g",
"3c7h",
"3c7o",
"3kst",
"3qed",
"3qee",
"3qef",
"3qz4",
"4mlg",
"4nov",
"4qqs",
"5a8c",
"5a8d",
"5glk",
"5gll",
"5glm",
"5gln",
"5glo",
"5glp",
"5glq",
"5glr",
"6xn0",
"6xn1",
"6xn2",
"8hcj",
"9no3"
] | 28 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
43,
12558,
2335,
88
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glycosyl Hydrolase Family 43 Enzymes | Glycosyl Hydrolase Family 43 Enzymes | Glycosyl_Hydrlase_43_Enz | 6 |
IPR052177 | 52,177 | Divisome-localized Glycosyl Hydrolase | Divisome_Glycosyl_Hydrolase | Family | 12,024 | true | false | This family of proteins includes glycosyl hydrolases that localize to the divisome, a complex involved in bacterial cell division. Members of this family are involved in the cleavage of peptidoglycans, specifically targeting regions that lack peptide side chains, known as denuded peptidoglycans. The enzymatic activity ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43405"
] | [
"Divisome_Glycosyl_Hydrolase"
] | [
12024
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.2.1.-",
"PWY-1921",
"PWY-5821",
"PWY-5976",
"PWY-6527",
"PWY-6717",
"PWY-6735",
"PWY-6737",
"PWY-6749",
"PWY-6784",
"PWY-6821",
"PWY-6848",
"PWY-6855",
"PWY-6906",
"PWY-6972",
"PWY-7056",
"PWY-7057",
"PWY-7074",
"PWY-7091",
"PWY-7133",
"PWY-7134",
"PWY-7256",
"PWY-7445... | [
"EC:3.2.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5821",
"METACYC:PWY-5976",
"METACYC:PWY-6527",
"METACYC:PWY-6717",
"METACYC:PWY-6735",
"METACYC:PWY-6737",
"METACYC:PWY-6749",
"METACYC:PWY-6784",
"METACYC:PWY-6821",
"METACYC:PWY-6848",
"METACYC:PWY-6855",
"METACYC:PWY-6906",
"METACYC:PWY-6... | 31 | [
"5oq2",
"5oq3"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctmdT21",
"unclassified sequences"
] | [
40,
11624,
210,
1,
149
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Family | Divisome-localized Glycosyl Hydrolase | Divisome-localized Glycosyl Hydrolase | Divisome_Glycosyl_Hydrolase | 9 |
IPR052178 | 52,178 | Short-chain dehydrogenase/reductase SAT3-like | SAT3-like | Family | 18,063 | true | true | This family of proteins includes short-chain dehydrogenases/reductases (SDRs) involved in various biosynthetic pathways for secondary metabolites in fungi and bacteria. These enzymes typically function in the reduction or oxidation of substrates using NAD(P)H as a cofactor. Members of this family are implicated in the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43618"
] | [
"Sec_Metab_Biosynth_SDR"
] | [
18063
] | 1 | [] | [] | [] | 0 | [
"2b4q",
"3afm",
"3afn",
"3pk0",
"9k8q",
"9k8r"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
17,
6117,
11757,
170,
2
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
10
] | 1 | true | Family | Short-chain dehydrogenase/reductase SAT3-like | Short-chain dehydrogenase/reductase SAT3-like | SAT3-like | 4 |
IPR052179 | 52,179 | D-alanyl-D-alanine carboxypeptidase-like | DD-CPase-like | Family | 14,605 | true | true | The protein family includes enzymes involved in peptidoglycan processing, such as D-alanyl-D-alanine carboxypeptidases and endopeptidases. These enzymes play a role in bacterial cell wall synthesis and remodeling by cleaving specific peptide bonds in peptidoglycan precursors. D-alanyl-D-alanine carboxypeptidases remove... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34385"
] | [
"Bact_PeptidoProc_Enz"
] | [
14605
] | 1 | [] | [] | [] | 0 | [
"4d0y",
"4f78",
"4jid",
"4mph",
"4muq",
"4mur",
"4mus",
"4mut",
"4nt9",
"4oak",
"4ox3",
"4ox5",
"4oxd",
"5hnm",
"5zhf",
"5zhw",
"6a6a"
] | 17 | [] | [] | [] | [] | 0 | [] | [
"IPR058233"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
14308,
128,
36,
133
] | 4 | [
"Arabidopsis thaliana"
] | [
1
] | 1 | true | Family | D-alanyl-D-alanine carboxypeptidase-like | D-alanyl-D-alanine carboxypeptidase-like | DD-CPase-like | 1 |
IPR052180 | 52,180 | NhaC Na(+)/H(+) Antiporter | NhaC_Na-H+_Antiporter | Family | 14,966 | true | false | This family of proteins is involved in the transport of ions across cellular membranes, functioning primarily as antiporters. They play a crucial role in maintaining pH homeostasis by exchanging sodium ions (Na+) for protons (H+). Some members are also capable of exchanging other ions such as arginine and ornithine, or... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33451"
] | [
"NhaC_Na-H+_Antiporter"
] | [
14966
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Siphoviridae sp. ct3z32",
"metagenomes"
] | [
14209,
28,
600,
1,
128
] | 5 | [] | [] | 0 | true | Family | NhaC Na(+)/H(+) Antiporter | NhaC Na(+)/H(+) Antiporter | NhaC_Na-H+_Antiporter | 2 |
IPR052182 | 52,182 | Glycogen_Maltodextrin_Phosphorylase | Glycogen/Maltodextrin_Phosph | Family | 7,822 | true | false | This family of proteins includes allosteric enzymes involved in carbohydrate metabolism. Members of this family catalyze the phosphorolytic cleavage of glycogen, maltodextrins, and other polysaccharides to produce glucose-1-phosphate. They play a key role in energy mobilization and are regulated by various mechanisms d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42655"
] | [
"Glycogen/Maltodextrin_Phosph"
] | [
7822
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.4.1.1",
"PWY-5941",
"PWY-6731",
"PWY-6737",
"PWY-7238"
] | [
"EC:2.4.1.1",
"METACYC:PWY-5941",
"METACYC:PWY-6731",
"METACYC:PWY-6737",
"METACYC:PWY-7238"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
382,
7179,
13,
248
] | 4 | [] | [] | 0 | true | Family | Glycogen_Maltodextrin_Phosphorylase | Glycogen_Maltodextrin_Phosphorylase | Glycogen/Maltodextrin_Phosph | 5 |
IPR052183 | 52,183 | Bacterial Insertion Sequence Transposase | IS_Transposase | Family | 13,890 | true | false | This family of proteins includes transposases that are responsible for the movement of insertion sequences within the genomes of bacteria. These enzymes facilitate the cut-and-paste mechanism of transposition, which can result in the insertion of these sequences into new genomic locations. Such mobility can contribute ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35528"
] | [
"IS_Transposase"
] | [
13890
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Punavirus",
"other sequences",
"unclassified sequences"
] | [
53,
13716,
38,
2,
6,
75
] | 6 | [] | [] | 0 | true | Family | Bacterial Insertion Sequence Transposase | Bacterial Insertion Sequence Transposase | IS_Transposase | 3 |
IPR052184 | 52,184 | Short-chain dehydrogenases/reductases (SDR) enzymes | SDR_enzymes | Family | 12,849 | true | false | The Short-chain dehydrogenases/reductases (SDR) family is involved in various biosynthetic pathways for natural products, including fungal metabolites, meroterpenoids, and isoprene degradation. Members of this family function as oxidoreductases, catalyzing NAD(+)-dependent reactions. They play roles in the formation of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45458"
] | [
"SDR_enzymes"
] | [
12849
] | 1 | [] | [] | [] | 0 | [
"5idq",
"5idw",
"5tqv",
"5tt1",
"5u1p",
"5uzx",
"5wqm",
"5wqn",
"5wqo",
"5wqp",
"7xwh",
"7xwi",
"7xwj",
"7xwk",
"7xwl",
"7xwm",
"7xwn",
"7ypd"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus thuringiensis phage MZTP02",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3,
1,
6662,
6078,
105
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Short-chain dehydrogenases/reductases (SDR) enzymes | Short-chain dehydrogenases/reductases (SDR) enzymes | SDR_enzymes | 4 |
IPR052185 | 52,185 | Inositol Phosphorylceramide Synthase-Related | IPC_Synthase-Related | Family | 11,706 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of sphingolipids, a class of lipids that play a crucial role in cell membrane structure and function. Members of this family are responsible for catalyzing the addition of a phosphorylinositol group to ceramide or dihydroceramide, forming in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31310"
] | [
"IPC_Synthase-Related"
] | [
11706
] | 1 | [] | [] | [] | 0 | [
"9ivc"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
272,
7361,
3910,
163
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
2,
1
] | 3 | true | Family | Inositol Phosphorylceramide Synthase-Related | Inositol Phosphorylceramide Synthase-Related | IPC_Synthase-Related | 4 |
IPR052186 | 52,186 | Hydantoin racemase-like | Hydantoin_racemase-like | Family | 10,166 | true | false | This family of proteins is involved in the racemization of 5-substituted hydantoins, facilitating the conversion of these compounds to L-amino acids. The racemization process occurs through the enolization of both D- and L-enantiomers of hydantoins, which may have various side chains, including arylalkyl and aliphatic ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28047"
] | [
"Hydantoin_racemase-like"
] | [
10166
] | 1 | [] | [] | [] | 0 | [
"3qvj",
"3qvk",
"3qvl",
"5lfd",
"5lg5"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
95,
8064,
1885,
122
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2
] | 3 | true | Family | Hydantoin racemase-like | Hydantoin racemase-like | Hydantoin_racemase-like | 3 |
IPR052187 | 52,187 | Lysosomal dipeptide transporter MFSD1 | MFSD1 | Family | 9,199 | true | true | This family of proteins includes lysosomal transporters that are crucial for maintaining liver homeostasis. Human MFSD1 is a lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol [ ]. Members of this... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23512"
] | [
"MFSD1"
] | [
9199
] | 1 | [] | [] | [] | 0 | [
"8r8q"
] | 1 | [
"PUB00154549"
] | [
"38507452"
] | [
"Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport."
] | [
2024
] | 1 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
129,
2902,
6096,
72
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
4,
9,
1,
2
] | 5 | true | Family | Lysosomal dipeptide transporter MFSD1 | Lysosomal dipeptide transporter MFSD1 | MFSD1 | 5 |
IPR052188 | 52,188 | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase-like | Ni-pincer_cofactor_biosynth | Family | 5,828 | true | true | This family of proteins is involved in the biosynthesis of a nickel-pincer cofactor, which is a (SCS)Ni(II) pincer complex and includes Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase (LarE) [ , ]. Members of this family catalyse the ATP-dependent incorporation of sulphur atoms into pyridinium-3,5-biscarb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43169"
] | [
"Ni-pincer_cofactor_biosynth"
] | [
5828
] | 1 | [] | [] | [] | 0 | [
"5udq",
"5udr",
"5uds",
"5udt",
"5udu",
"5udv",
"5udw",
"5udx",
"5unm",
"6b2m",
"6b2o",
"6dg3",
"6utp",
"6utq",
"6utr",
"6utt",
"8cnz",
"8cp3",
"8cp4"
] | 19 | [
"PUB00085157",
"PUB00086644"
] | [
"24710389",
"27114550"
] | [
"Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.",
"Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion."
] | [
2014,
2016
] | 2 | [] | [
"IPR005232"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
996,
4426,
166,
240
] | 4 | [] | [] | 0 | true | Family | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase-like | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase-like | Ni-pincer_cofactor_biosynth | 6 |
IPR052189 | 52,189 | L-aspartate N-monooxygenase (nitrosuccinate-forming) | L-asp_N-monooxygenase_NS-form | Family | 11,273 | true | false | The L-aspartate N-monooxygenase (nitrosuccinate-forming) family is involved in the biosynthesis of various compounds with biological activity. Members of the family catalyze the iterative oxidation of L-aspartic acid to nitrosuccinic acid via intermediate steps involving N-hydroxyaspartic acid and nitrososuccinic acid.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40254"
] | [
"L-asp_N-monooxygenase_NS-form"
] | [
11273
] | 1 | [] | [] | [] | 0 | [
"8cp2",
"8cp5"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
10938,
305,
30
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | L-aspartate N-monooxygenase (nitrosuccinate-forming) | L-aspartate N-monooxygenase (nitrosuccinate-forming) | L-asp_N-monooxygenase_NS-form | 4 |
IPR052190 | 52,190 | Release factor glutamine methyltransferase Mtq2-like | Mtq2-like | Family | 11,391 | true | true | The PrmC-related methyltransferase family is composed of enzymes that primarily function as methyltransferases using S-adenosyl-L-methionine as the methyl donor. Members of the family are known to methylate proteins, including the methylation of 'Lys-12' of histone H4 and 'Gln' residues within specific motifs of target... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45875"
] | [
"Euk-Arch_PrmC-MTase"
] | [
11391
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.297",
"R-HSA-156581",
"R-HSA-72764",
"R-MMU-156581",
"R-MMU-72764",
"R-SCE-156581",
"R-SCE-72764",
"R-SPO-156581",
"R-SPO-72764"
] | [
"EC:2.1.1.297",
"REACTOME:R-HSA-156581",
"REACTOME:R-HSA-72764",
"REACTOME:R-MMU-156581",
"REACTOME:R-MMU-72764",
"REACTOME:R-SCE-156581",
"REACTOME:R-SCE-72764",
"REACTOME:R-SPO-156581",
"REACTOME:R-SPO-72764"
] | 9 | [
"3q87",
"6h1d",
"6h1e",
"6k0x",
"6khs",
"6kmr",
"6kms",
"6ped",
"7rc2",
"7rc3",
"7rc4",
"7rc6",
"8cnc",
"8qdg",
"8qdi",
"9fim",
"9fke",
"9fkg",
"9fkm",
"9fkv",
"9fkw",
"9fl4",
"9fl5"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
899,
5830,
4597,
65
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
1,
1,
2,
1,
2,
3,
1,
1,
12
] | 12 | true | Family | Release factor glutamine methyltransferase Mtq2-like | Release factor glutamine methyltransferase Mtq2-like | Mtq2-like | 9 |
IPR052191 | 52,191 | tRNA nucleotidyltransferase/poly(A) polymerase I | tRNA_ntf/polyA_polymerase_I | Family | 9,074 | true | false | The Poly(A) polymerase I family is characterized by enzymes that add poly(A) tails to the 3' ends of various RNAs, a process that typically marks these RNAs for degradation. The addition of poly(A) tails is a crucial step in the regulation of gene expression, as it affects the rate of RNA transcript degradation and pla... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43051"
] | [
"tRNA_ntf/polyA_polymerase_I"
] | [
9074
] | 1 | [
"EC"
] | [
"2.7.7.19"
] | [
"EC:2.7.7.19"
] | 1 | [
"3aqk",
"3aql",
"3aqm",
"3aqn"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7209,
1758,
107
] | 3 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
1,
6,
21
] | 4 | true | Family | tRNA nucleotidyltransferase/poly(A) polymerase I | tRNA nucleotidyltransferase/poly(A) polymerase I | tRNA_ntf/polyA_polymerase_I | 8 |
IPR052192 | 52,192 | Ionotropic receptor | Ionotropic_Rcpt | Family | 17,619 | true | true | The Ionotropic Receptor family is characterized by its role in sensory perception within the antenna of insects, particularly in Drosophila. Members of the family are integral to the detection of environmental changes such as temperature (thermosensation) and humidity (hygrosensation), as well as the recognition of spe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42643"
] | [
"Insect_Ionotropic_Sensory_Rcpt"
] | [
17619
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-204005",
"R-DME-399710",
"R-DME-416993",
"R-DME-438066",
"R-DME-5694530",
"R-DME-8849932"
] | [
"REACTOME:R-DME-204005",
"REACTOME:R-DME-399710",
"REACTOME:R-DME-416993",
"REACTOME:R-DME-438066",
"REACTOME:R-DME-5694530",
"REACTOME:R-DME-8849932"
] | 6 | [
"4zdm"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aestuariispira insulae",
"Eukaryota"
] | [
1,
17618
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
3,
92
] | 2 | true | Family | Ionotropic receptor | Ionotropic receptor | Ionotropic_Rcpt | 1 |
IPR052193 | 52,193 | Peptidase C59 family enzymes | Peptidase_C59 | Family | 8,867 | true | false | The peptidase C59 family includes enzymes with diverse functions such as bile salt hydrolases and penicillin acylases. Bile salt hydrolases deconjugate glycine- and taurine-linked bile salts in the intestines of humans and animals, releasing amino acid residues and bile acids. They can hydrolyze major human bile salts ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35527"
] | [
"Peptidase_C59"
] | [
8867
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METAC... | [
"3.5.1",
"3.5.1.-",
"3.5.1.24",
"PWY-1822",
"PWY-5497",
"PWY-5784",
"PWY-5846",
"PWY-6409",
"PWY-6899",
"PWY-7018",
"PWY-7403",
"PWY-7430",
"PWY-7496",
"PWY-7571",
"PWY-7652",
"PWY-7771",
"PWY-7821",
"PWY-7850",
"PWY-8135",
"PWY-8229",
"PWY-8293",
"PWY-8402",
"PWY-8418",
... | [
"EC:3.5.1",
"EC:3.5.1.-",
"EC:3.5.1.24",
"METACYC:PWY-1822",
"METACYC:PWY-5497",
"METACYC:PWY-5784",
"METACYC:PWY-5846",
"METACYC:PWY-6409",
"METACYC:PWY-6899",
"METACYC:PWY-7018",
"METACYC:PWY-7403",
"METACYC:PWY-7430",
"METACYC:PWY-7496",
"METACYC:PWY-7571",
"METACYC:PWY-7652",
"META... | 26 | [
"2bjf",
"2bjg",
"2hez",
"2hf0",
"2iwm",
"2oqc",
"2pva",
"2quy",
"2rf8",
"2rg2",
"2rlc",
"2z71",
"3hbc",
"3mji",
"3pva",
"4wl2",
"4wl3",
"5gs7",
"5hke",
"5j9r",
"5x8z",
"5x9i",
"5y7p",
"6a8q",
"6a8t",
"6ufy",
"6uh4",
"7sve",
"7svf",
"7svg",
"7svh",
"7svi"... | 46 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
78,
8334,
361,
11,
83
] | 5 | [] | [] | 0 | true | Family | Peptidase C59 family enzymes | Peptidase C59 family enzymes | Peptidase_C59 | 7 |
IPR052194 | 52,194 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | MESH1 | Family | 6,843 | true | false | This family of proteins includes guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolases, commonly known as MESH1 enzymes. These enzymes play a crucial role in the bacterial stringent response to starvation by hydrolyzing the signaling molecule ppGpp (guanosine pentaphosphate or tetraphosphate), which is involved in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46246"
] | [
"MESH1"
] | [
6843
] | 1 | [
"EC"
] | [
"3.1.7.2"
] | [
"EC:3.1.7.2"
] | 1 | [
"3nqw",
"3nr1",
"4yf1",
"5vxa",
"6yvc",
"6z3n",
"6z3o",
"7qoc",
"7qod",
"7qoe",
"7smg"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
88,
4961,
1535,
139,
120
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3,
6,
4
] | 6 | true | Family | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | MESH1 | 9 |
IPR052195 | 52,195 | Bacterial Alkyl/Aryl-Sulfatase | Bact_Alkyl/Aryl-Sulfatase | Family | 7,415 | true | false | The alkylsulfatase family comprises enzymes that catalyze the hydrolysis of alkyl sulfate esters, a reaction that is crucial for the utilization of sulfate esters as carbon or sulfur sources. Members of this family are involved in the degradation of various substrates, including the detergent sodium dodecyl sulfate (SD... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43223"
] | [
"Bact_Alkyl/Aryl-Sulfatase"
] | [
7415
] | 1 | [
"EC"
] | [
"3.1.6.21"
] | [
"EC:3.1.6.21"
] | 1 | [
"2cfu",
"2cfz",
"2cg2",
"2cg3",
"2yhe",
"4av7",
"4axh",
"4nur",
"4pdx",
"5a23",
"5aij",
"5ajl",
"7tl5"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
37,
6343,
761,
4,
270
] | 5 | [
"Escherichia coli (strain K12)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Bacterial Alkyl/Aryl-Sulfatase | Bacterial Alkyl/Aryl-Sulfatase | Bact_Alkyl/Aryl-Sulfatase | 2 |
IPR052196 | 52,196 | Bacterial Potassium Binding | Bact_Kbp | Family | 19,333 | true | false | The protein family includes highly specific potassium binding proteins that are essential for normal growth under high external potassium levels. Members of the family may function as sensors for cytoplasmic potassium concentration, binding potassium ions and undergoing significant conformational changes upon binding. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34700"
] | [
"Bact_Kbp"
] | [
19333
] | 1 | [] | [] | [] | 0 | [
"3jc8",
"3jc9",
"6ve2",
"7pvc",
"7vcm",
"9g8s",
"9gb2"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Viruses",
"unclassified sequences"
] | [
18916,
34,
6,
141,
236
] | 5 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | Bacterial Potassium Binding | Bacterial Potassium Binding | Bact_Kbp | 4 |
IPR052197 | 52,197 | Complex I 49 kDa subunit-like | ComplexI_49kDa-like | Family | 5,412 | true | false | This family of proteins includes subunits of enzyme complexes involved in energy metabolism, such as hydrogenases and NADH-ubiquinone oxidoreductase (complex I). They play roles in redox reactions, coupling these to proton translocation across membranes, which is essential for energy conservation in the form of proton ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43485"
] | [
"ComplexI_49kDa-like"
] | [
5412
] | 1 | [] | [] | [] | 0 | [
"6cfw",
"7z0s",
"7z0t"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
708,
4488,
3,
213
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Complex I 49 kDa subunit-like | Complex I 49 kDa subunit-like | ComplexI_49kDa-like | 9 |
IPR052198 | 52,198 | Indolepyruvate oxidoreductase subunit IorB-like | IorB_oxidoreductase | Family | 4,113 | true | true | This family of proteins is involved in the oxidative decarboxylation of arylpyruvates. Members of this family function as enzymes that facilitate the ferredoxin-dependent conversion process, which is a key step in the metabolic pathway. The enzymatic activity is crucial for the catabolism of aromatic compounds, where i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43854"
] | [
"IorB_Oxidoreductase"
] | [
4113
] | 1 | [
"EC"
] | [
"1.2.7.8"
] | [
"EC:1.2.7.8"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR017719"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
564,
3348,
4,
197
] | 4 | [] | [] | 0 | true | Family | Indolepyruvate oxidoreductase subunit IorB-like | Indolepyruvate oxidoreductase subunit IorB-like | IorB_oxidoreductase | 2 |
IPR052199 | 52,199 | Myo-inositol 1-phosphate synthase | MIPS | Family | 5,691 | true | false | This family of proteins includes enzymes that are key in the biosynthesis of myo-inositol, a molecule with various cellular functions including as a precursor for inositol phospholipids and inositol phosphates. Members of this family catalyze the NAD-dependent conversion of glucose 6-phosphate to 1D-myo-inositol 3-phos... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43125"
] | [
"MIPS"
] | [
5691
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"5.5.1.4",
"PWY-2301",
"PWY-4661",
"PWY-6372",
"PWY-6580",
"PWY-6664",
"R-MTU-879299"
] | [
"EC:5.5.1.4",
"METACYC:PWY-2301",
"METACYC:PWY-4661",
"METACYC:PWY-6372",
"METACYC:PWY-6580",
"METACYC:PWY-6664",
"REACTOME:R-MTU-879299"
] | 7 | [
"1gr0",
"3cin",
"6k96"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Menderavirus",
"unclassified sequences"
] | [
534,
4821,
18,
5,
313
] | 5 | [] | [] | 0 | true | Family | Myo-inositol 1-phosphate synthase | Myo-inositol 1-phosphate synthase | MIPS | 8 |
IPR052200 | 52,200 | Protoporphyrinogen IX dehydrogenase | Protoporphyrinogen_IX_DH | Family | 6,924 | true | false | This family of proteins catalyzes the 6-electron oxidation of protoporphyrinogen IX to protoporphyrin IX, a key step in the biosynthesis of heme. The reaction is mediated by different electron acceptors depending on the environmental oxygen availability. Under anaerobic conditions, members of this family typically use ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38030"
] | [
"Protoporphyrinogen_IX_DH"
] | [
6924
] | 1 | [
"EC",
"METACYC"
] | [
"1.3.5.3",
"PWY-5531"
] | [
"EC:1.3.5.3",
"METACYC:PWY-5531"
] | 2 | [
"8g64"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
407,
6281,
113,
123
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protoporphyrinogen IX dehydrogenase | Protoporphyrinogen IX dehydrogenase | Protoporphyrinogen_IX_DH | 8 |
IPR052201 | 52,201 | Leucine-rich repeat-containing regulator of pluripotency | LRR-containing_regulator | Family | 8,427 | true | false | This family of proteins includes members that are highly expressed in stem cells and may play a role in the regulation of pluripotency. They are implicated in maintaining the normal expression of key pluripotency regulators such as POU5F1/OCT4 and KLF4. Additionally, these proteins are important for the expression of m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24111"
] | [
"LRR-containing_regulator"
] | [
8427
] | 1 | [] | [] | [] | 0 | [
"7n6g",
"7sqc",
"8j07",
"8th8",
"8tid",
"9e5c",
"9fqr",
"9j7j"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
113,
8309,
2,
3
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
7,
10,
4,
8,
2
] | 5 | true | Family | Leucine-rich repeat-containing regulator of pluripotency | Leucine-rich repeat-containing regulator of pluripotency | LRR-containing_regulator | 9 |
IPR052203 | 52,203 | GHMP Kinase-Related Enzymes | GHMP_Kinase-Related | Family | 5,148 | true | false | This family of proteins includes enzymes that are involved in the salvage pathways of various sugars. Members of this family exhibit kinase activity, where they catalyze the phosphorylation of specific sugar substrates using ATP or GTP. Some members are bifunctional, having both kinase and pyrophosphorylase activities,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32463"
] | [
"GHMP_Kinase-Related"
] | [
5148
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.7.1.52",
"PWY-6",
"R-HSA-6787639",
"R-MMU-6787639"
] | [
"EC:2.7.1.52",
"METACYC:PWY-6",
"REACTOME:R-HSA-6787639",
"REACTOME:R-MMU-6787639"
] | 4 | [
"3k85",
"4usk",
"4usm",
"4ut4",
"4utg",
"5yys",
"9iip",
"9iis",
"9iit"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
61,
2335,
5,
2612,
135
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
9,
1,
1,
11,
3,
5,
7,
8
] | 8 | true | Family | GHMP Kinase-Related Enzymes | GHMP Kinase-Related Enzymes | GHMP_Kinase-Related | 9 |
IPR052204 | 52,204 | PpiC/parvulin rotamase | PpiC/parvulin_rotamase | Family | 6,181 | true | false | The PpiC/parvulin rotamase family is characterized by its peptidyl-prolyl cis-trans isomerase (PPIase) activity, which plays a crucial role in accelerating the folding of proteins. Members of the family exhibit a preference for substrates with hydrophobic side chains, such as leucine and phenylalanine, at the P1 positi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43629"
] | [
"PpiC/parvulin_rotamase"
] | [
6181
] | 1 | [
"EC"
] | [
"5.2.1.8"
] | [
"EC:5.2.1.8"
] | 1 | [
"1jns",
"1jnt"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
30,
5027,
1047,
76,
1
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
4,
7
] | 4 | true | Family | PpiC/parvulin rotamase | PpiC/parvulin rotamase | PpiC/parvulin_rotamase | 4 |
IPR052205 | 52,205 | Flagellar biosynthesis and adherence | FliO/MopB | Family | 6,711 | true | false | The FliO/MopB family is involved in bacterial motility and virulence, with members playing roles in flagellar biosynthesis and adherence. Proteins in the family may assist in the localization and assembly of flagellar components and adhesins on the bacterial surface, which are crucial for movement and host interaction.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38766"
] | [
"FliO/MopB"
] | [
6711
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cyprideis torosa",
"unclassified sequences"
] | [
6638,
1,
72
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Flagellar biosynthesis and adherence | Flagellar biosynthesis and adherence | FliO/MopB | 7 |
IPR052206 | 52,206 | All-trans-retinol saturase | Retinol_saturase | Family | 5,634 | true | false | This family of proteins includes enzymes that are involved in the metabolism of vitamin A. They catalyze the saturation of all-trans-retinol, converting it to all-trans-13,14-dihydroretinol, a step in the vitamin A metabolic pathway. These enzymes do not show activity towards all-trans-retinoic acid or various cis-isom... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46091"
] | [
"Retinol_saturase"
] | [
5634
] | 1 | [
"EC",
"REACTOME"
] | [
"1.3.99.23",
"R-HSA-975634"
] | [
"EC:1.3.99.23",
"REACTOME:R-HSA-975634"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
32,
2807,
2687,
2,
106
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
8,
6,
9
] | 4 | true | Family | All-trans-retinol saturase | All-trans-retinol saturase | Retinol_saturase | 5 |
IPR052207 | 52,207 | Max-like/E-box-binding transcription factors | Max-like/E-box_TFs | Family | 11,745 | true | false | The protein family in question is involved in transcriptional regulation, with members forming sequence-specific DNA-binding complexes that recognize the E box motif 5'-CACGTG-3'. These complexes can act as transcriptional repressors or activators, depending on the context and interacting partners. Family members are i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15741"
] | [
"Max-like/E-box_TFs"
] | [
11745
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-163358",
"R-HSA-163358",
"R-HSA-163680",
"R-HSA-163765",
"R-HSA-163767",
"R-RNO-163358"
] | [
"REACTOME:R-CEL-163358",
"REACTOME:R-HSA-163358",
"REACTOME:R-HSA-163680",
"REACTOME:R-HSA-163765",
"REACTOME:R-HSA-163767",
"REACTOME:R-RNO-163358"
] | 6 | [
"5f74"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Vibrio campbellii"
] | [
11744,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
4,
9,
9,
17,
22,
2,
19
] | 7 | true | Family | Max-like/E-box-binding transcription factors | Max-like/E-box-binding transcription factors | Max-like/E-box_TFs | 3 |
IPR052208 | 52,208 | DmX-like/RAVE complex component | DmX-like/RAVE_component | Family | 9,193 | true | false | This family of proteins includes members that are involved in various cellular processes. Some proteins in this family may function as scaffold proteins, interacting with other proteins such as MADD and RAB3GA on synaptic vesicles, and are implicated in the regulation of neuronal and endocrine homeostatic processes. Ot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13950"
] | [
"DmX-like/RAVE_component"
] | [
9193
] | 1 | [] | [] | [] | 0 | [
"9cop"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9193
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
8,
8,
2,
10,
7,
1,
6,
12,
1,
1,
29
] | 12 | true | Family | DmX-like/RAVE complex component | DmX-like/RAVE complex component | DmX-like/RAVE_component | 5 |
IPR052209 | 52,209 | Adenosylcobinamide Amidohydrolase | CbiZ | Family | 2,708 | true | false | The CbiZ family is involved in the de novo biosynthesis of coenzyme B12. Members of the CbiZ family, such as adenosylcobinamide amidohydrolases, catalyze the conversion of adenosylcobinamide to adenosylcobyric acid, an essential intermediate in this biosynthetic pathway. The function of some members within the family r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35336"
] | [
"CbiZ"
] | [
2708
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Pseudo-nitzschia australis",
"metagenomes"
] | [
648,
2029,
1,
30
] | 4 | [] | [] | 0 | true | Family | Adenosylcobinamide Amidohydrolase | Adenosylcobinamide Amidohydrolase | CbiZ | 3 |
IPR052211 | 52,211 | Cpx two-component system auxiliary protein | Cpx_auxiliary_protein | Family | 5,173 | true | false | This family of proteins includes periplasmic components involved in bacterial stress response and protein quality control. Members act as auxiliary proteins in the Cpx two-component envelope stress response system, modulating the response to various inducers. They bind the periplasmic domain of the sensor histidine kin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38102"
] | [
"Cpx_auxiliary_protein"
] | [
5173
] | 1 | [] | [] | [] | 0 | [
"3itf",
"3o39",
"3oeo",
"3qzc",
"5wnw",
"5wo1",
"5wo2",
"5wo3",
"6bie",
"6owx",
"6owy",
"6owz"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Thermococcus litoralis",
"unclassified sequences"
] | [
5144,
4,
1,
24
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Cpx two-component system auxiliary protein | Cpx two-component system auxiliary protein | Cpx_auxiliary_protein | 1 |
IPR052212 | 52,212 | Pleckstrin homology-like domain-containing protein | PH-like_domain | Family | 7,987 | true | false | This family of proteins includes members that contain a Pleckstrin homology (PH) domain, which is known to be involved in binding to phosphoinositides. This interaction is important in cellular signaling pathways and membrane dynamics. Additionally, some members of this family are implicated in the assembly of the post... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12156"
] | [
"PH-like_domain"
] | [
7987
] | 1 | [] | [] | [] | 0 | [
"8whk",
"8whm"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
7986,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
141,
7,
36,
21,
23
] | 5 | true | Family | Pleckstrin homology-like domain-containing protein | Pleckstrin homology-like domain-containing protein | PH-like_domain | 3 |
IPR052213 | 52,213 | Partitioning defective 3 homolog | PAR3 | Family | 7,659 | true | false | The PAR3 family consists of adapter proteins involved in the establishment and maintenance of cell polarity, playing a pivotal role in asymmetrical cell division. Members of the family are central to the formation of epithelial tight junctions and are implicated in various cellular processes, including the targeting of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16484"
] | [
"PAR3"
] | [
7659
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2173791",
"R-HSA-2173791",
"R-HSA-420029",
"R-MMU-2173791",
"R-MMU-420029",
"R-RNO-2173791",
"R-RNO-420029"
] | [
"REACTOME:R-CEL-2173791",
"REACTOME:R-HSA-2173791",
"REACTOME:R-HSA-420029",
"REACTOME:R-MMU-2173791",
"REACTOME:R-MMU-420029",
"REACTOME:R-RNO-2173791",
"REACTOME:R-RNO-420029"
] | 7 | [
"1wg6",
"2fne",
"2k1z",
"2k20",
"2koh",
"2koj",
"2kom",
"2ns5",
"2ogp",
"3zee",
"4i6p",
"5oak",
"6jue",
"9imp"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7659
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
20,
6,
17,
28,
20
] | 6 | true | Family | Partitioning defective 3 homolog | Partitioning defective 3 homolog | PAR3 | 2 |
IPR052215 | 52,215 | Plant ABC transporter G | Plant_ABCG | Family | 8,590 | true | false | The ABC transporter G family is involved in various transport functions across the plant cell membrane. Members of this family are implicated in the development and maintenance of plant structures such as the cuticle, root suberin, and pollen coat by regulating the transport of lipids, cutin, waxes, and possibly lignin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48042"
] | [
"Plant_ABCG"
] | [
8590
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8590
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
1,
50,
41
] | 4 | true | Family | Plant ABC transporter G | Plant ABC transporter G | Plant_ABCG | 5 |
IPR052216 | 52,216 | CRISPR-associated Csm3 endoribonuclease | CRISPR_Csm3_endoribonuclease | Family | 2,988 | true | false | This family of proteins is associated with the CRISPR adaptive immune system, which protects against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of this family are involved in the CRISPR mechanism where they act as endoribonucleases targeting single-stranded RNA (ss... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35579"
] | [
"CRISPR_Csm3_endoribonuclease"
] | [
2988
] | 1 | [] | [] | [] | 0 | [
"4n0l",
"4qts",
"5yjd",
"6ae2",
"6ifk",
"6ifl",
"6ifn",
"6ifr",
"6ifu",
"6ify",
"6ifz",
"6ig0",
"6iqw",
"6mur",
"6mus",
"6mut",
"6muu",
"6nbt",
"6nud",
"6nue",
"6o7e",
"6o7h",
"6o7i",
"6xn3",
"6xn4",
"6xn5",
"6xn7",
"7uzw",
"7uzx",
"7uzy",
"7uzz",
"7v00"... | 108 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
342,
2611,
35
] | 3 | [] | [] | 0 | true | Family | CRISPR-associated Csm3 endoribonuclease | CRISPR-associated Csm3 endoribonuclease | CRISPR_Csm3_endoribonuclease | 8 |
IPR052217 | 52,217 | Mitochondrial and Peroxisomal Carrier Protein | Mito/Peroxisomal_Carrier | Family | 6,795 | true | false | This family of proteins includes mitochondrial and peroxisomal transporters that are involved in the translocation of various cofactors across the organelle membranes. Members of this family are characterized by their ability to transport molecules such as coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mon... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45939"
] | [
"Mito/Peroxisomal_Carrier"
] | [
6795
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-389599",
"R-DDI-9603798",
"R-HSA-389599",
"R-HSA-9603798",
"R-MMU-389599",
"R-MMU-9603798"
] | [
"REACTOME:R-DDI-389599",
"REACTOME:R-DDI-9603798",
"REACTOME:R-HSA-389599",
"REACTOME:R-HSA-9603798",
"REACTOME:R-MMU-389599",
"REACTOME:R-MMU-9603798"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6795
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
4,
2,
8,
2,
3,
8
] | 6 | true | Family | Mitochondrial and Peroxisomal Carrier Protein | Mitochondrial and Peroxisomal Carrier Protein | Mito/Peroxisomal_Carrier | 7 |
IPR052219 | 52,219 | DNA Photolyase Class-2 | Photolyase_Class-2 | Family | 4,145 | true | false | This family of proteins is involved in the cellular response to ultraviolet (UV) radiation-induced DNA damage. Members of this family catalyze the light-dependent repair of cyclobutyl pyrimidine dimers, which are DNA lesions formed between adjacent pyrimidine bases on the same DNA strand after exposure to UV light. The... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10211"
] | [
"Photolyase_Class-2"
] | [
4145
] | 1 | [
"EC"
] | [
"4.1.99.3"
] | [
"EC:4.1.99.3"
] | 1 | [
"2xry",
"2xrz",
"3umv",
"4cdm",
"4cdn",
"5o86",
"5o8d",
"5o8e",
"5zcw",
"7f8t",
"7viw",
"7vix",
"7viy",
"7viz",
"7vj0",
"7vj1",
"7vj2",
"7vj3",
"7vj4",
"7vj5",
"7vj6",
"7vj7",
"7vj8",
"7vj9",
"7vja",
"7vjb",
"7vjc",
"7vje",
"7vjg",
"7vjh",
"7vji",
"7vjj"... | 62 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
81,
1033,
2945,
73,
13
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
15,
5,
3,
11
] | 5 | true | Family | DNA Photolyase Class-2 | DNA Photolyase Class-2 | Photolyase_Class-2 | 5 |
IPR052220 | 52,220 | Methyltransferase-like protein 25 | METTL25 | Family | 6,507 | true | false | The METTL25 family comprises proteins with a putative function as methyltransferases. Members of this family, known as Methyltransferase-like protein 25B and Probable methyltransferase-like protein 25, are characterized by their similarity to other methyltransferases, suggesting a role in the transfer of methyl groups ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12496"
] | [
"METTL25"
] | [
6507
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
6453,
54
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
2,
5,
3,
9,
5,
1,
3,
8,
8
] | 10 | true | Family | Methyltransferase-like protein 25 | Methyltransferase-like protein 25 | METTL25 | 4 |
IPR052221 | 52,221 | SLC35F Solute Transporter | SLC35F_Transporter | Family | 6,716 | true | false | This family of proteins is involved in the transport of solutes across cellular membranes. Members are characterized as putative solute transporters and are part of the SLC35F solute transporter family, which suggests a role in the facilitated or active transport of specific substrates, although the exact substrates an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14233"
] | [
"SLC35F_Transporter"
] | [
6716
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6716
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea... | [
24,
4,
6,
5,
2,
1,
14,
6,
1,
24
] | 10 | true | Family | SLC35F Solute Transporter | SLC35F Solute Transporter | SLC35F_Transporter | 5 |
IPR052222 | 52,222 | Arabidopsis DESIGUAL | DESIGUAL | Family | 7,881 | true | false | The DESIGUAL family is involved in various developmental processes in Arabidopsis thaliana. Members of the family contribute to secondary cell wall biology, particularly in lignin biosynthesis, which is crucial for plant structural integrity and defense. Some members are also implicated in ensuring bilateral symmetry d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31769"
] | [
"DESIGUAL"
] | [
7881
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7881
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
57,
56,
55
] | 3 | true | Family | Arabidopsis DESIGUAL | Arabidopsis DESIGUAL | DESIGUAL | 8 |
IPR052223 | 52,223 | Actin Cytoskeleton Regulatory | Actin_Cytoskeleton_Reg | Family | 6,172 | true | false | This family of proteins is involved in the regulation of the actin cytoskeleton. Members of this family target specific proteins to the actin cytoskeleton and are essential for the modulation of cytoskeletal organization. They play a role in the formation of cellular structures such as stress fibers and rootlets, and a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17271"
] | [
"Actin_Cytoskeleton_Reg"
] | [
6172
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6802952",
"R-HSA-9662360",
"R-HSA-9662361"
] | [
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6172
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
78,
1,
26,
14,
18
] | 6 | true | Family | Actin Cytoskeleton Regulatory | Actin Cytoskeleton Regulatory | Actin_Cytoskeleton_Reg | 6 |
IPR052224 | 52,224 | THAP domain-containing protein | THAP_domain_protein | Family | 4,461 | true | false | This family of proteins includes members with sequence-specific DNA-binding activity, suggesting a role in transcriptional regulation. Some members have been shown to function as transcriptional repressors in vitro. Additionally, there is evidence that overexpression of certain family members can lead to cell cycle arr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46927"
] | [
"THAP_domain_protein"
] | [
4461
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4461
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens"
] | [
1,
3,
6
] | 3 | true | Family | THAP domain-containing protein | THAP domain-containing protein | THAP_domain_protein | 8 |
IPR052225 | 52,225 | Serine/arginine repetitive matrix | Ser/Arg_repetitive_matrix | Family | 6,239 | true | false | The Serine/arginine repetitive matrix protein family is involved in various pre-mRNA splicing and processing events. Members of this family are integral components of both pre- and post-splicing multiprotein mRNP complexes and play a role in the splicing of U12-type introns as part of the minor spliceosome. They are kn... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23148"
] | [
"Ser/Arg_repetitive_matrix"
] | [
6239
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-159236",
"R-HSA-72163",
"R-HSA-72187",
"R-HSA-73856",
"R-HSA-9013418",
"R-HSA-9013422",
"R-MMU-159236",
"R-MMU-72163",
"R-MMU-72187",
"R-MMU-73856",
"R-MMU-9013418",
"R-MMU-9013422",
"R-SCE-159236"
] | [
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-HSA-9013418",
"REACTOME:R-HSA-9013422",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-73856",
"REACTOME:R-MMU-9013418",
"REACTOME:R-MMU-901342... | 13 | [
"1mp1",
"6ff4",
"6ff7",
"7abg",
"7abh",
"7abi",
"7dvq",
"8i0p",
"8i0r"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota",
"Invertebrate iridescent virus 22",
"marine sediment metagenome"
] | [
3,
6234,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
5,
2,
12,
8,
2,
6,
7,
1,
1,
32
] | 12 | true | Family | Serine/arginine repetitive matrix | Serine/arginine repetitive matrix | Ser/Arg_repetitive_matrix | 3 |
IPR052227 | 52,227 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein | Arf-Rho-GAP_ANK-PH_domain | Family | 5,623 | true | false | This family of proteins includes GTPase-activating proteins (GAPs) that are involved in the modulation of the actin cytoskeleton. They are activated by binding to specific phosphoinositides, including phosphatidylinositol 3,4,5-trisphosphate and, to a lesser extent, phosphatidylinositol 3,4-bisphosphate. These proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45899"
] | [
"Arf-Rho-GAP_ANK-PH_domain"
] | [
5623
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8849469",
"R-HSA-8980692",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013423",
"R-MMU-8849469",
"R-MMU-8980692",
"R-MMU-9013148",
"R-MMU-9013149",
"R-MMU-9013423"
] | [
"REACTOME:R-HSA-8849469",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013423",
"REACTOME:R-MMU-8849469",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013148",
"REACTOME:R-MMU-9013149",
"REACTOME:R-MMU-9013423"
] | 10 | [
"1x40",
"2cod",
"2kg5",
"5jcp",
"5jd0",
"7yir",
"7yis"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli",
"Eukaryota"
] | [
3,
5620
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
20,
3,
21,
15,
1,
18
] | 7 | true | Family | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein | Arf-Rho-GAP_ANK-PH_domain | 3 |
IPR052229 | 52,229 | Collagen VI and Biomineralization Protein PIF | Collagen-VI/PIF | Family | 2,545 | true | false | This family of proteins includes collagen VI chains that serve as cell-binding proteins. They are involved in the formation of a network that supports cells in connective tissues. Collagen VI is important for maintaining the integrity of various organs and tissues throughout the body. Additionally, a member of this fam... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22588"
] | [
"Collagen-VI/PIF"
] | [
2545
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-1650814",
"R-HSA-1442490",
"R-HSA-1650814",
"R-HSA-186797",
"R-HSA-2022090",
"R-HSA-216083",
"R-HSA-3000178",
"R-HSA-419037",
"R-HSA-8948216",
"R-MMU-1442490",
"R-MMU-1650814",
"R-MMU-186797",
"R-MMU-2022090",
"R-MMU-216083",
"R-MMU-3000178",
"R-MMU-419037",
"R-MMU-8948216"
] | [
"REACTOME:R-GGA-1650814",
"REACTOME:R-HSA-1442490",
"REACTOME:R-HSA-1650814",
"REACTOME:R-HSA-186797",
"REACTOME:R-HSA-2022090",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-419037",
"REACTOME:R-HSA-8948216",
"REACTOME:R-MMU-1442490",
"REACTOME:R-MMU-1650814",
"REACTOME:R... | 17 | [
"1cqp",
"1dgq",
"1lfa",
"1mjn",
"1mq9",
"1mqa",
"1rd4",
"1t0p",
"1xdd",
"1xdg",
"1xuo",
"1zon",
"1zoo",
"1zop",
"2ica",
"2o7n",
"3bn3",
"3bqm",
"3bqn",
"3e2m",
"3eoa",
"3eob",
"3f74",
"3f78",
"3hi6",
"3m6f",
"3tcx",
"4ixd",
"6tnj",
"7kc3",
"7kc5",
"7kc6"... | 34 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
34,
148,
2362,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
7,
10,
4,
11
] | 5 | true | Family | Collagen VI and Biomineralization Protein PIF | Collagen VI and Biomineralization Protein PIF | Collagen-VI/PIF | 4 |
IPR052230 | 52,230 | DNA polymerase eta | DNA_polymerase_eta | Family | 5,179 | true | false | The DNA polymerase eta family consists of specialized DNA polymerases involved in translesion synthesis (TLS), a DNA repair mechanism that allows DNA replication to proceed past lesions or distortions within the DNA helix. Members of the family are characterized by their ability to insert nucleotides opposite lesions, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45873"
] | [
"DNA_polymerase_eta"
] | [
5179
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.7",
"R-DME-110320",
"R-HSA-110320",
"R-HSA-5656169",
"R-HSA-5685942",
"R-MMU-110320",
"R-MMU-5656169",
"R-MMU-5685942",
"R-SCE-110320",
"R-SCE-5656169",
"R-SPO-110320",
"R-SPO-5656169"
] | [
"EC:2.7.7.7",
"REACTOME:R-DME-110320",
"REACTOME:R-HSA-110320",
"REACTOME:R-HSA-5656169",
"REACTOME:R-HSA-5685942",
"REACTOME:R-MMU-110320",
"REACTOME:R-MMU-5656169",
"REACTOME:R-MMU-5685942",
"REACTOME:R-SCE-110320",
"REACTOME:R-SCE-5656169",
"REACTOME:R-SPO-110320",
"REACTOME:R-SPO-5656169"
... | 12 | [
"1jih",
"2r8j",
"2r8k",
"2wtf",
"2xgp",
"2xgq",
"3jaa",
"3mfh",
"3mfi",
"3mr2",
"3mr3",
"3mr5",
"3mr6",
"3oha",
"3ohb",
"3si8",
"3tq1",
"4dl2",
"4dl3",
"4dl4",
"4dl5",
"4dl6",
"4dl7",
"4ecq",
"4ecr",
"4ecs",
"4ect",
"4ecu",
"4ecv",
"4ecw",
"4ecx",
"4ecy"... | 249 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
5175
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
1,
7,
3,
1,
6,
3,
1,
1,
54
] | 12 | true | Family | DNA polymerase eta | DNA polymerase eta | DNA_polymerase_eta | 7 |
IPR052231 | 52,231 | Rho GEF and signaling-related domain-containing protein | Rho_GEF_signaling-related | Family | 5,033 | true | false | This family of proteins includes members that are implicated in intracellular signaling and cytoskeleton dynamics. Some proteins within this family are suggested to function as guanine nucleotide exchange factors (GEFs), which are known to activate small GTPases by facilitating the exchange of GDP for GTP, thereby trig... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45845"
] | [
"Rho_GEF_signaling-related"
] | [
5033
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-8980692",
"R-HSA-9013106",
"R-HSA-9013148",
"R-HSA-9013149"
] | [
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013106",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
5033
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
50,
8,
18,
14,
16
] | 5 | true | Family | Rho GEF and signaling-related domain-containing protein | Rho GEF and signaling-related domain-containing protein | Rho_GEF_signaling-related | 4 |
IPR052232 | 52,232 | Receptor-like Ser/Thr Protein Kinase | RLK_Ser/Thr-Kinase | Family | 6,360 | true | false | This family of proteins includes receptor-like kinases that are predicted to function in signal transduction pathways. They are characterized by their kinase activity, specifically phosphorylating serine and threonine residues. These proteins are part of the larger protein kinase superfamily and are likely involved in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47984"
] | [
"RLK_Ser/Thr-Kinase"
] | [
6360
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6360
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
52,
44,
79
] | 3 | true | Family | Receptor-like Ser/Thr Protein Kinase | Receptor-like Ser/Thr Protein Kinase | RLK_Ser/Thr-Kinase | 1 |
IPR052233 | 52,233 | Rho-type GTPase guanine nucleotide-exchange factors | Rho-type_GEFs | Family | 4,970 | true | false | This family of proteins includes guanine nucleotide-exchange factors (GEFs) that specifically activate Rho-type GTPases, primarily Rho1, by catalyzing the exchange of GDP for GTP. These proteins play a crucial role in the regulation of cell wall biosynthesis, cell wall integrity, septum formation, and the organization ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46572"
] | [
"Rho-type_GEFs"
] | [
4970
] | 1 | [] | [] | [] | 0 | [
"5o51"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4970
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
3
] | 3 | true | Family | Rho-type GTPase guanine nucleotide-exchange factors | Rho-type GTPase guanine nucleotide-exchange factors | Rho-type_GEFs | 4 |
IPR052234 | 52,234 | U5 snRNP Complex Component | U5_snRNP_Component | Family | 4,769 | true | false | This family of proteins is essential for the process of pre-mRNA splicing, a critical step in gene expression where introns are removed and exons are joined to form a mature mRNA transcript. Members of this family are integral components of the spliceosome, a complex molecular machine that orchestrates the splicing pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44006"
] | [
"U5_snRNP_Component"
] | [
4769
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-72163",
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165",
"R-SPO-72163"
] | [
"REACTOME:R-DDI-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165",
"REACTOME:R-SPO-72163"
] | 6 | [
"3jb9",
"3jcr",
"5mqf",
"5o9z",
"5xjc",
"5yzg",
"5z56",
"5z57",
"5z58",
"6ah0",
"6ahd",
"6ff7",
"6icz",
"6id0",
"6id1",
"6qdv",
"6qw6",
"6qx9",
"6zym",
"7abg",
"7abi",
"7dvq",
"7w59",
"7w5a",
"7w5b",
"8c6j",
"8ch6",
"8h6e",
"8h6j",
"8h6k",
"8h6l",
"8i0p"... | 62 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Mimivirus",
"ecological metagenomes",
"uncultured marine group II/III euryarchaeote KM3_17_G02"
] | [
37,
4722,
5,
4,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
4,
2,
1,
1,
4,
2,
1,
3,
5,
1,
7
] | 11 | true | Family | U5 snRNP Complex Component | U5 snRNP Complex Component | U5_snRNP_Component | 1 |
IPR052235 | 52,235 | Nephronectin domain-containing protein | Nephronectin_domain | Family | 10,642 | true | false | This family of proteins is involved in the regulation of kidney development and organ morphogenesis. Members of this family are known to interact with integrin alpha-8/beta-1, serving as functional ligands that regulate the expression of growth factors essential for these developmental processes. They also play roles i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24050"
] | [
"Nephronectin_domain"
] | [
10642
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2129379",
"R-HSA-1566948",
"R-HSA-2129379",
"R-HSA-9830364",
"R-HSA-9830674",
"R-MMU-2129379",
"R-RNO-1566948",
"R-RNO-2129379"
] | [
"REACTOME:R-CEL-2129379",
"REACTOME:R-HSA-1566948",
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-9830364",
"REACTOME:R-HSA-9830674",
"REACTOME:R-MMU-2129379",
"REACTOME:R-RNO-1566948",
"REACTOME:R-RNO-2129379"
] | 8 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
15,
10627
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
27,
47,
22,
33
] | 5 | true | Family | Nephronectin domain-containing protein | Nephronectin domain-containing protein | Nephronectin_domain | 5 |
IPR052237 | 52,237 | Ataxin-7-like transcription regulator | Ataxin-7-like_regulator | Family | 4,552 | true | false | This family of proteins is involved in neurodegeneration and transcription regulation. Members act as components of the STAGA transcription coactivator-HAT complex, mediating interactions with CRX, a photoreceptor cell-specific transcription factor, and contributing to CRX-dependent gene activation. They are also neces... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15117"
] | [
"Ataxin-7-like_regulator"
] | [
4552
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-5689880",
"R-MMU-5689880"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-5689880",
"REACTOME:R-MMU-5689880"
] | 3 | [
"2kkr",
"7ktr",
"7kts",
"8h7g"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4552
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
20,
19,
17
] | 4 | true | Family | Ataxin-7-like transcription regulator | Ataxin-7-like transcription regulator | Ataxin-7-like_regulator | 8 |
IPR052239 | 52,239 | Serine/threonine-specific protein kinases | Ser/Thr-specific_kinases | Family | 4,782 | true | false | This family of proteins includes serine/threonine kinases that are involved in a variety of cellular processes. Members are known to phosphorylate substrates on serine and threonine residues, which is a key mechanism in regulating intracellular signaling pathways. Some proteins in this family have been shown to autopho... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45998"
] | [
"Ser/Thr-specific_kinases"
] | [
4782
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [
"2buj"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
4776
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
5,
7,
1,
4,
4,
1,
1,
14
] | 12 | true | Family | Serine/threonine-specific protein kinases | Serine/threonine-specific protein kinases | Ser/Thr-specific_kinases | 4 |
IPR052240 | 52,240 | SAP domain-containing ribonucleoprotein | SAP_domain_ribonucleoprotein | Family | 4,300 | false | false | The SAP domain-containing ribonucleoprotein family includes SARNP from animals and its orthologues from yeast THO1 and mlo1. This family is involved in various cellular processes including DNA and RNA binding, transcriptional and translational control, and mRNA export. Members of the family have a higher affinity for s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46551"
] | [
""
] | [
4300
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-159236",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU-159236",
"R-MMU-72187",
"R-MMU-73856",
"R-RNO-159236",
"R-RNO-72187",
"R-RNO-73856"
] | [
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-73856",
"REACTOME:R-RNO-159236",
"REACTOME:R-RNO-72187",
"REACTOME:R-RNO-73856"
] | 9 | [
"1h1j",
"1zrj",
"2do1",
"4uzw"
] | 4 | [
"PUB00154991",
"PUB00154992",
"PUB00154993",
"PUB00154994"
] | [
"15338056",
"17196963",
"20844015",
"37578863"
] | [
"Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function.",
"Intracellular characterization of DDX39, a novel growth-associated RNA helicase.",
"ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.",
"Struc... | [
2004,
2007,
2010,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Jiangella alkaliphila",
"Methanobacteriati",
"Viruses",
"metagenomes"
] | [
4280,
1,
10,
3,
6
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
1,
8,
5,
1,
8,
1,
1
] | 9 | true | Family | SAP domain-containing ribonucleoprotein | SAP domain-containing ribonucleoprotein | SAP_domain_ribonucleoprotein | 6 |
IPR052241 | 52,241 | Solute Carrier Family 66 (SLC66) and Scramblase ANY1 | SLC66/Scramblase_ANY1 | Family | 4,297 | true | false | The Solute Carrier Family 66 (SLC66) is involved in the bidirectional transport of phospholipids across the phospholipid bilayer, affecting membrane asymmetry. Members of the SLC66 family, such as scramblase ANY1 in yeast, facilitate the movement of phosphatidylserine (PS) and phosphatidylethanolamine (PE) between memb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14856"
] | [
"SLC66/Scramblase_ANY1"
] | [
4297
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4297
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
12,
5,
8,
3,
1,
5,
1
] | 8 | true | Family | Solute Carrier Family 66 (SLC66) and Scramblase ANY1 | Solute Carrier Family 66 (SLC66) and Scramblase ANY1 | SLC66/Scramblase_ANY1 | 1 |
IPR052242 | 52,242 | Mitochondrial 3-hydroxyacyl-CoA dehydrogenase | Mito_3-hydroxyacyl-CoA_DH | Family | 4,201 | true | false | This family of proteins includes mitochondrial enzymes involved in the fatty acid beta-oxidation pathway. They catalyze the third step in the beta-oxidation cycle, specifically for medium and short-chain 3-hydroxy fatty acyl-CoAs ranging from C4 to C10 in length. Additionally, these proteins have a regulatory role in i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43561"
] | [
"Mito_3-hydroxyacyl-CoA_DH"
] | [
4201
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.1.1.35",
"PWY-1361",
"PWY-5136",
"PWY-5177",
"PWY-5789",
"PWY-6435",
"PWY-6443",
"PWY-6458",
"PWY-6583",
"PWY-6863",
"PWY-6883",
"PWY-6944",
"PWY-6945",
"PWY-6946",
"PWY-7007",
"PWY-7094",
"PWY-7216",
"PWY-7401",
"PWY-7778",
"PWY-7779",
"PWY-8152",
"PWY-8179",
"PWY-818... | [
"EC:1.1.1.35",
"METACYC:PWY-1361",
"METACYC:PWY-5136",
"METACYC:PWY-5177",
"METACYC:PWY-5789",
"METACYC:PWY-6435",
"METACYC:PWY-6443",
"METACYC:PWY-6458",
"METACYC:PWY-6583",
"METACYC:PWY-6863",
"METACYC:PWY-6883",
"METACYC:PWY-6944",
"METACYC:PWY-6945",
"METACYC:PWY-6946",
"METACYC:PWY-... | 56 | [
"1f0y",
"1f12",
"1f14",
"1f17",
"1il0",
"1lsj",
"1lso",
"1m75",
"1m76",
"2hdh",
"3had",
"3hdh",
"3rqs",
"4dyd",
"4e12",
"4e13",
"4j0e",
"4j0f"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
32,
1363,
2779,
27
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
18,
1,
4
] | 5 | true | Family | Mitochondrial 3-hydroxyacyl-CoA dehydrogenase | Mitochondrial 3-hydroxyacyl-CoA dehydrogenase | Mito_3-hydroxyacyl-CoA_DH | 6 |
IPR052243 | 52,243 | Mitochondrial inner membrane organizing protein | Mito_inner_membrane_organizer | Family | 4,117 | true | false | This family of proteins is involved in the structural organization of the mitochondrial inner membrane. Members of this family are known to interact with the mitochondrial contact site and cristae organizing system (MICOS) complex, as well as the sorting and assembly machinery (SAM) complex located in the mitochondrial... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44157"
] | [
"Mito_inner_membrane_organizer"
] | [
4117
] | 1 | [
"REACTOME"
] | [
"R-HSA-8949613"
] | [
"REACTOME:R-HSA-8949613"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
22,
4092,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1,
9,
3,
3,
1
] | 7 | true | Family | Mitochondrial inner membrane organizing protein | Mitochondrial inner membrane organizing protein | Mito_inner_membrane_organizer | 9 |
IPR052244 | 52,244 | High-affinity choline transporter | Choline_transporter | Family | 4,358 | true | false | This family of proteins includes high-affinity sodium-coupled choline transmembrane symporters. They function as electrogenic, voltage-dependent transporters with variable charge/choline stoichiometry. These proteins are crucial for acetylcholine synthesis, as they transport choline from the synaptic cleft into presyna... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45897"
] | [
"Choline_transporter"
] | [
4358
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-264642",
"R-CEL-425366",
"R-DME-264642",
"R-DME-425366",
"R-HSA-264642",
"R-HSA-425366",
"R-HSA-5619114",
"R-HSA-5658471",
"R-MMU-264642",
"R-MMU-425366",
"R-RNO-264642",
"R-RNO-425366"
] | [
"REACTOME:R-CEL-264642",
"REACTOME:R-CEL-425366",
"REACTOME:R-DME-264642",
"REACTOME:R-DME-425366",
"REACTOME:R-HSA-264642",
"REACTOME:R-HSA-425366",
"REACTOME:R-HSA-5619114",
"REACTOME:R-HSA-5658471",
"REACTOME:R-MMU-264642",
"REACTOME:R-MMU-425366",
"REACTOME:R-RNO-264642",
"REACTOME:R-RNO-4... | 12 | [
"8j74",
"8j75",
"8j76",
"8j77",
"8zqo",
"8zqp",
"8zqq",
"8zqr",
"9bfi",
"9bfj",
"9bfk",
"9bim"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
130,
4225,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
4,
2,
3
] | 6 | true | Family | High-affinity choline transporter | High-affinity choline transporter | Choline_transporter | 5 |
IPR052245 | 52,245 | Plant Stress & Developmental Transcription Factors | Plant_Stress_Dev_TF | Family | 5,677 | true | false | The protein family described is involved in transcriptional regulation, with members acting as transcription factors that bind to specific DNA elements in gene promoters. These transcription factors play roles in plant stress responses, including cold, drought, and salt stress, as well as in sugar-repressed transcripti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44191"
] | [
"Plant_Stress_Dev_TF"
] | [
5677
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5677
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
32,
46
] | 3 | true | Family | Plant Stress & Developmental Transcription Factors | Plant Stress & Developmental Transcription Factors | Plant_Stress_Dev_TF | 2 |
IPR052246 | 52,246 | Cell Polarization and PKA Anchoring | Cell_Polariz_PKAAnc | Family | 3,885 | true | false | The protein family is involved in various cellular processes including cell polarization, division, and bud site selection. Members anchor regulatory subunits of protein kinase A (PKA) to mitochondria or the plasma membrane, potentially influencing apoptosis through BAD phosphorylation and inactivation. They may also f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13155"
] | [
"Cell_Polariz_PKAAnc"
] | [
3885
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-983231",
"R-HSA-983231",
"R-MMU-983231",
"R-SCE-983231",
"R-SPO-983231"
] | [
"REACTOME:R-CEL-983231",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-983231",
"REACTOME:R-SCE-983231",
"REACTOME:R-SPO-983231"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3885
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
4,
2,
9,
2,
1,
9,
1,
1
] | 9 | true | Family | Cell Polarization and PKA Anchoring | Cell Polarization and PKA Anchoring | Cell_Polariz_PKAAnc | 3 |
IPR052247 | 52,247 | Meiotic Crossover Helicase | Meiotic_Crossover_Helicase | Family | 4,288 | true | false | This family of proteins includes ATP-dependent DNA helicases that play a crucial role in meiotic recombination. They are involved in the formation of crossovers and the complete synapsis of homologous chromosomes, which are essential for accurate chromosome segregation during meiosis. These helicases preferentially unw... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47835"
] | [
"Meiotic_Crossover_Helicase"
] | [
4288
] | 1 | [
"EC"
] | [
"5.6.2.4"
] | [
"EC:5.6.2.4"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4288
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
24,
11,
8,
1,
3,
5,
1,
13
] | 9 | true | Family | Meiotic Crossover Helicase | Meiotic Crossover Helicase | Meiotic_Crossover_Helicase | 7 |
IPR052248 | 52,248 | Arf-GAP domain and FG repeat-containing protein | Arf-GAP_FG-repeat_protein | Family | 4,070 | true | false | This family of proteins is involved in vesicular transport processes, particularly in vesicle docking and fusion events during acrosome biogenesis. Members of this family may also play a role in RNA trafficking or localization within cells. Additionally, certain proteins within this family can interact with viral compo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46134"
] | [
"Arf-GAP_FG-repeat_protein"
] | [
4070
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8856825",
"R-HSA-8856828",
"R-MMU-8856828",
"R-RNO-8856825",
"R-RNO-8856828"
] | [
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-MMU-8856828",
"REACTOME:R-RNO-8856825",
"REACTOME:R-RNO-8856828"
] | 5 | [
"2d9l",
"2olm"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4070
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
9,
13,
8,
12
] | 5 | true | Family | Arf-GAP domain and FG repeat-containing protein | Arf-GAP domain and FG repeat-containing protein | Arf-GAP_FG-repeat_protein | 3 |
IPR052249 | 52,249 | Roquin domain-containing protein | Roquin_domain | Family | 3,764 | true | false | This family of proteins functions as post-transcriptional repressors, regulating mRNA stability by recognizing and binding to conserved stem loop motifs in the 3'-UTR of target mRNAs, leading to mRNA deadenylation and degradation. Members of this family are involved in controlling inflammatory responses and the differe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13139"
] | [
"Roquin_domain"
] | [
3764
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [
"3x1o",
"4qi0",
"4qi2",
"4qik",
"4qil",
"4txa",
"4ulw",
"4ywq",
"4z30",
"4z31",
"4zlc",
"4zld",
"5f5f",
"5f5h",
"6tqa",
"6tqb",
"8rhs"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3764
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
22,
1,
7,
9,
8
] | 6 | true | Family | Roquin domain-containing protein | Roquin domain-containing protein | Roquin_domain | 7 |
IPR052250 | 52,250 | Protein disulfide-isomerase TMX3 | PDI_TMX3 | Family | 4,171 | true | false | The TMX3 family proteins are probable disulfide isomerases involved in the folding of proteins with disulfide bonds. They may function as dithiol oxidases and play a role in regulating redox signals. Members of the TMX3 family are also implicated in maintaining endoplasmic reticulum-mitochondria contact sites, which ar... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46426"
] | [
"PDI_TMX3"
] | [
4171
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.3.4.1",
"R-HSA-114608",
"R-MMU-114608",
"R-SPO-114608"
] | [
"EC:5.3.4.1",
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-SPO-114608"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Flavivirga spongiicola",
"Phaeocystis globosa virus PgV-16T",
"viral metagenome"
] | [
4133,
1,
1,
36
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
5,
1,
6,
3,
1,
4,
1
] | 8 | true | Family | Protein disulfide-isomerase TMX3 | Protein disulfide-isomerase TMX3 | PDI_TMX3 | 7 |
IPR052251 | 52,251 | Glycosyl Hydrolase and Zinc Finger Regulators | GH-ZnFinger_Regulators | Family | 3,781 | true | false | This family of proteins includes enzymes and transcriptional regulators. The enzymatic members are involved in the breakdown of complex carbohydrates, such as dextran, which may influence bacterial adherence to surfaces like teeth. Other members of the family, characterized by zinc finger domains, are implicated in the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15507"
] | [
"GH-ZnFinger_Regulators"
] | [
3781
] | 1 | [] | [] | [] | 0 | [
"1x3c"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Limosilactobacillus reuteri"
] | [
3780,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
15,
12,
8
] | 4 | true | Family | Glycosyl Hydrolase and Zinc Finger Regulators | Glycosyl Hydrolase and Zinc Finger Regulators | GH-ZnFinger_Regulators | 6 |
IPR052252 | 52,252 | Cell surface hyaluronidase CEMIP/CEMIP2 | CEMIP/CEMIP2 | Family | 3,550 | false | false | This family of proteins is involved in the metabolism of hyaluronic acid (HA), a major component of the extracellular matrix. It includes Cell migration-inducing and hyaluronan-binding protein (CEMIP) and Cell surface hyaluronidase (CEMIP2) which mediate the depolymerization of high-molecular-weight HA into intermediat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15535"
] | [
""
] | [
3550
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.35",
"PWY-6573",
"R-DDI-2160916",
"R-HSA-2160916",
"R-MMU-2160916"
] | [
"EC:3.2.1.35",
"METACYC:PWY-6573",
"REACTOME:R-DDI-2160916",
"REACTOME:R-HSA-2160916",
"REACTOME:R-MMU-2160916"
] | 5 | [
"8c6i"
] | 1 | [
"PUB00089707",
"PUB00154995",
"PUB00154996",
"PUB00154997",
"PUB00154998",
"PUB00154999"
] | [
"23509262",
"23990668",
"24269685",
"37527776",
"33647313",
"34624311"
] | [
"KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.",
"Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.",
"N-Terminal signal sequence is required for cellular trafficking and hyaluronan-depo... | [
2013,
2013,
2014,
2023,
2021,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
14,
3535,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
10,
5,
7
] | 4 | true | Family | Cell surface hyaluronidase CEMIP/CEMIP2 | Cell surface hyaluronidase CEMIP/CEMIP2 | CEMIP/CEMIP2 | 1 |
IPR052253 | 52,253 | CR1/CR2 motif-containing transcription regulator | CR1/CR2-DNA-binding_regulator | Family | 3,794 | true | false | This family of proteins includes transcription factors that are characterized by their ability to bind DNA through specific motifs, such as CR1 and CR2, which mediate sequence-specific DNA binding. Members of this family are involved in the regulation of gene expression by binding to enhancer or promoter elements of ta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13006"
] | [
"CR1/CR2-DNA-binding_regulator"
] | [
3794
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-212436",
"R-MMU-212436"
] | [
"REACTOME:R-HSA-212436",
"REACTOME:R-MMU-212436"
] | 2 | [
"7dta"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3794
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
6,
9,
7,
7
] | 5 | true | Family | CR1/CR2 motif-containing transcription regulator | CR1/CR2 motif-containing transcription regulator | CR1/CR2-DNA-binding_regulator | 8 |
IPR052254 | 52,254 | CUL4-DDB1 E3 ligase complex substrate receptor | CUL4-DDB1_E3_ligase_receptor | Family | 3,863 | true | false | This family of proteins appears to be involved in the ubiquitin-proteasome system, specifically as substrate receptors for the CUL4-DDB1 E3 ubiquitin-protein ligase complex. Members of this family may play a role in targeting proteins for ubiquitination and subsequent degradation, which is a critical process for mainta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44472"
] | [
"CUL4-DDB1_E3_ligase_receptor"
] | [
3863
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8951664",
"R-HSA-8951664",
"R-SPO-8951664"
] | [
"REACTOME:R-CEL-8951664",
"REACTOME:R-HSA-8951664",
"REACTOME:R-SPO-8951664"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3863
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea... | [
9,
2,
3,
11,
2,
3,
3,
2,
1,
9
] | 10 | true | Family | CUL4-DDB1 E3 ligase complex substrate receptor | CUL4-DDB1 E3 ligase complex substrate receptor | CUL4-DDB1_E3_ligase_receptor | 3 |
IPR052255 | 52,255 | RNA polymerase II subunit 5-mediating protein | RNA_pol_II_subunit5-mediator | Family | 3,861 | true | false | This family of proteins is involved in the regulation of gene transcription and cellular growth signaling pathways. Members act as transcriptional repressors, working with corepressors to regulate transcription factors such as androgen receptors. Some family members are implicated in tumor suppression by inhibiting gen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15111"
] | [
"RNA_pol_II_subunit5-mediator"
] | [
3861
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
3860,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
3,
1,
7,
5,
1,
4,
5,
19
] | 10 | true | Family | RNA polymerase II subunit 5-mediating protein | RNA polymerase II subunit 5-mediating protein | RNA_pol_II_subunit5-mediator | 9 |
IPR052256 | 52,256 | E3 ubiquitin-protein ligase CHFR | E3_ubiquitin-ligase_CHFR | Family | 3,968 | true | false | This family of proteins includes E3 ubiquitin-protein ligases involved in the antephase checkpoint of the cell cycle. They function by delaying the onset of mitosis in response to microtubule poisons, acting in early prophase before chromosome condensation. These proteins are implicated in signaling mitotic stress thro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16079"
] | [
"E3_ubiquitin-ligase_CHFR"
] | [
3968
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [
"1lgp",
"1lgq",
"2xoc",
"2xoy",
"2xoz",
"2xp0"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3968
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
6,
5,
3,
1,
5,
7,
11
] | 8 | true | Family | E3 ubiquitin-protein ligase CHFR | E3 ubiquitin-protein ligase CHFR | E3_ubiquitin-ligase_CHFR | 6 |
IPR052258 | 52,258 | Diverse Functionality Domain-containing Protein | Diverse_Func_Domain-Protein | Family | 2,053 | true | false | This family of proteins includes a variety of functions, such as structural components in fibrous materials, antibacterial activity, and potential roles in cellular structure and regulation. One member is a core component of silk, contributing to the formation of a strong, insoluble, and chemically inert filament. Anot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37612"
] | [
"Diverse_Func_Domain-Protein"
] | [
2053
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
15,
523,
1485,
15,
15
] | 5 | [
"Arabidopsis thaliana",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
2,
1,
12
] | 5 | true | Family | Diverse Functionality Domain-containing Protein | Diverse Functionality Domain-containing Protein | Diverse_Func_Domain-Protein | 8 |
IPR052259 | 52,259 | Nucleoredoxin-like | Nucleoredoxin-like | Family | 3,677 | true | false | This family of proteins includes probable thiol-disulfide oxidoreductases that are likely involved in various redox reactions. Members of this family may function in processes such as pollen tube growth and pollen function in plants, although some members do not require this activity for in vitro pollen tube growth. Th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13871"
] | [
"Nucleoredoxin-like"
] | [
3677
] | 1 | [
"EC"
] | [
"1.8.1.8"
] | [
"EC:1.8.1.8"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
30,
3645,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
9,
10,
28
] | 4 | true | Family | Nucleoredoxin-like | Nucleoredoxin-like | Nucleoredoxin-like | 6 |
IPR052261 | 52,261 | Glycosyltransferase 13 | Glycosyltransferase_13 | Family | 3,515 | true | false | The glycosyltransferase 13 family is responsible for the initiation of complex N-linked carbohydrate formation. Members of this family play a crucial role in the conversion of high-mannose N-glycans to hybrid and complex N-glycans. This enzymatic activity is essential for various biological processes, including proper ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10468"
] | [
"Glycosyltransferase_13"
] | [
3515
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.1.101",
"PWY-7426",
"PWY-7920",
"R-CEL-964739",
"R-HSA-964739",
"R-HSA-9683686",
"R-HSA-9694548",
"R-MMU-964739",
"R-RNO-964739"
] | [
"EC:2.4.1.101",
"METACYC:PWY-7426",
"METACYC:PWY-7920",
"REACTOME:R-CEL-964739",
"REACTOME:R-HSA-964739",
"REACTOME:R-HSA-9683686",
"REACTOME:R-HSA-9694548",
"REACTOME:R-MMU-964739",
"REACTOME:R-RNO-964739"
] | 9 | [
"1fo8",
"1fo9",
"1foa",
"2am3",
"2am4",
"2am5",
"2apc"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanolobus mangrovi"
] | [
30,
3484,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
3,
6,
2,
7,
4,
3,
2,
10
] | 9 | true | Family | Glycosyltransferase 13 | Glycosyltransferase 13 | Glycosyltransferase_13 | 4 |
IPR052262 | 52,262 | E2F-responsive SERTA domain-containing protein | E2F-SERTA_domain_protein | Family | 3,415 | true | false | This family of proteins includes coregulators that interact with E2F-responsive promoters, integrating signals from PHD- and bromodomain-containing transcription factors. They modulate the transcriptional activity of E2F1/TFDP1 complexes, influencing cell cycle progression and cellular proliferation. Members of this fa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16277"
] | [
"E2F-SERTA_domain_protein"
] | [
3415
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3415
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
4,
5,
9,
10
] | 5 | true | Family | E2F-responsive SERTA domain-containing protein | E2F-responsive SERTA domain-containing protein | E2F-SERTA_domain_protein | 1 |
IPR052263 | 52,263 | GPI Anchor Biosynthesis Protein | GPI_Anchor_Biosynth | Family | 3,297 | true | false | This family of proteins is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are glycolipid structures that anchor proteins to the cell membrane. Members of this family function as part of a complex that catalyzes the initial step of GPI biosynthesis, transferring N-acetylglucosamine fro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46346"
] | [
"GPI_Anchor_Biosynth"
] | [
3297
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-162710",
"R-MMU-162710"
] | [
"REACTOME:R-HSA-162710",
"REACTOME:R-MMU-162710"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3297
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
1,
3,
5,
1,
6,
1,
1
] | 9 | true | Family | GPI Anchor Biosynthesis Protein | GPI Anchor Biosynthesis Protein | GPI_Anchor_Biosynth | 1 |
IPR052265 | 52,265 | Gamma-class Carbonic Anhydrase | Gamma-CA | Family | 1,742 | true | false | The gamma-class carbonic anhydrase family is involved in the reversible hydration of carbon dioxide, which is essential for photosynthetic carbon dioxide fixation in organisms that grow on acetate. Members of the family function as scaffold proteins for the assembly of beta-carboxysomes, structures that concentrate car... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43360"
] | [
"Gamma-CA"
] | [
1742
] | 1 | [] | [] | [] | 0 | [
"1qq0",
"1qre",
"1qrf",
"1qrg",
"1qrl",
"1qrm",
"1thj",
"3kwc",
"3kwd",
"3kwe",
"3otm",
"3otz",
"3ou9",
"3oup",
"3ow5",
"6has",
"6hba",
"6hbb",
"6hbc",
"6mr1",
"6z1g",
"7d6c",
"7o4z",
"7o54",
"9fwv",
"9lin"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
114,
1611,
17
] | 3 | [] | [] | 0 | true | Family | Gamma-class Carbonic Anhydrase | Gamma-class Carbonic Anhydrase | Gamma-CA | 9 |
IPR052266 | 52,266 | Mitochondrial Rho GTPase/EF-hand domain-containing protein | Miro-EF-hand_domain | Family | 9,439 | true | false | This family of proteins includes mitochondrial Rho GTPases and EF-hand calcium-binding domain-containing proteins. The mitochondrial Rho GTPases are involved in the regulation of mitochondrial morphology, distribution, and development, playing crucial roles in cell division, gamete development, and pollen tube growth. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46819"
] | [
"Miro-EF-hand_domain"
] | [
9439
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.5.-",
"R-BTA-5689880",
"R-BTA-9013419",
"R-BTA-9013425",
"R-CEL-5689880",
"R-CEL-9013419",
"R-CEL-9013425",
"R-DME-5689880",
"R-DME-9013419",
"R-DME-9013425",
"R-DRE-5689880",
"R-DRE-9013419",
"R-DRE-9013425",
"R-HSA-5635838",
"R-HSA-5689880",
"R-HSA-9013419",
"R-HSA-9013425",
... | [
"EC:3.6.5.-",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-9013419",
"REACTOME:R-BTA-9013425",
"REACTOME:R-CEL-5689880",
"REACTOME:R-CEL-9013419",
"REACTOME:R-CEL-9013425",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-9013419",
"REACTOME:R-DME-9013425",
"REACTOME:R-DRE-5689880",
"REACTOME:R-DRE-9013... | 22 | [
"4c0j",
"4c0k",
"4c0l",
"5ksz",
"5kty",
"5ku1",
"9e2p"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9439
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
2,
13,
4,
6,
10,
1,
12,
14,
31
] | 10 | true | Family | Mitochondrial Rho GTPase/EF-hand domain-containing protein | Mitochondrial Rho GTPase/EF-hand domain-containing protein | Miro-EF-hand_domain | 3 |
IPR052268 | 52,268 | Sterile alpha motif domain-containing protein | SAM_domain-containing_protein | Family | 3,203 | true | false | This family of proteins includes members that are involved in important cellular signaling pathways. Specifically, one characterized member is essential for normal photoreceptor differentiation and is implicated in the epidermal growth factor receptor (EGFR) signaling cascade in the eye. It is believed to function in t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR20843"
] | [
"SAM_domain-containing_protein"
] | [
3203
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-209190",
"R-DME-209214",
"R-DME-432553"
] | [
"REACTOME:R-DME-209190",
"REACTOME:R-DME-209214",
"REACTOME:R-DME-432553"
] | 3 | [
"3bs5",
"3bs7",
"8bw8",
"8bw9",
"9k1l"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3203
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
2,
5,
6,
15
] | 6 | true | Family | Sterile alpha motif domain-containing protein | Sterile alpha motif domain-containing protein | SAM_domain-containing_protein | 8 |
IPR052269 | 52,269 | Golgi apparatus maintenance and PI4KB interaction protein | Golgi-PI4KB_interaction | Family | 2,987 | true | false | This family of proteins is involved in the structural maintenance of the Golgi apparatus by interacting with the protein giantin, which is crucial for protein transport between the endoplasmic reticulum and the Golgi. Members of this family are also implicated in hormone-induced steroid biosynthesis in Leydig cells. Th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22973"
] | [
"Golgi-PI4KB_interaction"
] | [
2987
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-432722",
"R-MMU-432722",
"R-RNO-432722"
] | [
"REACTOME:R-HSA-432722",
"REACTOME:R-MMU-432722",
"REACTOME:R-RNO-432722"
] | 3 | [
"2n72",
"2n73",
"5lz1",
"5lz3",
"5lz6",
"5tdq",
"6hln",
"6hlt",
"6hlv",
"6hlw",
"6hm8",
"6hmv",
"6q67",
"6q68",
"6q69"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2987
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
6,
1,
3,
6,
6
] | 6 | true | Family | Golgi apparatus maintenance and PI4KB interaction protein | Golgi apparatus maintenance and PI4KB interaction protein | Golgi-PI4KB_interaction | 7 |
IPR052270 | 52,270 | Centrosome-associated contractile fiber protein | CACF_protein | Family | 3,298 | true | false | This family of proteins is involved in the structural integrity and dynamics of centrosome-associated contractile fibers. Members of this family interact with CETN2, a centrin protein, through specific binding regions that contain a conserved tryptophan residue at their C-terminal ends. This interaction is crucial for ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22028"
] | [
"CACF_protein"
] | [
3298
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Catenulispora yoronensis",
"Eukaryota"
] | [
1,
3297
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
4,
10,
12,
11
] | 5 | true | Family | Centrosome-associated contractile fiber protein | Centrosome-associated contractile fiber protein | CACF_protein | 8 |
IPR052271 | 52,271 | Glycerophosphoryl Diester Phosphodiesterase-Related | GDPD-Related | Family | 2,660 | true | false | This family of proteins is involved in the hydrolysis of lysoglycerophospholipids to generate lysophosphatidic acid (LPA) and corresponding amines. Members of this family exhibit lysophospholipase D activity, with a preference for substrates such as 1-O-alkyl-sn-glycero-3-phosphocholine, lysophosphatidylcholine, and N-... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42758"
] | [
"GDPD-Related"
] | [
2660
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"3.1.4.-",
"PWY-5978",
"PWY-6129",
"PWY-6689",
"PWY-7119",
"PWY-7366",
"R-HSA-6814848"
] | [
"EC:3.1.4.-",
"METACYC:PWY-5978",
"METACYC:PWY-6129",
"METACYC:PWY-6689",
"METACYC:PWY-7119",
"METACYC:PWY-7366",
"REACTOME:R-HSA-6814848"
] | 7 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
30,
2629,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
4,
5,
2,
14,
1
] | 5 | true | Family | Glycerophosphoryl Diester Phosphodiesterase-Related | Glycerophosphoryl Diester Phosphodiesterase-Related | GDPD-Related | 3 |
IPR052272 | 52,272 | GT106 glycosyltransferase | GT106_glycosyltransferase | Family | 3,835 | true | false | This family of proteins includes glycosyltransferases, specifically classified within the GT106 group. Members of this family are involved in the transfer of fucose residues to various substrates, a process that is critical for modifying the properties of proteins and other molecules. One characterized function within ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31933"
] | [
"GT106_glycosyltransferase"
] | [
3835
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
3835
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
28,
17,
55
] | 3 | true | Family | GT106 glycosyltransferase | GT106 glycosyltransferase | GT106_glycosyltransferase | 3 |
IPR052273 | 52,273 | Peptidyl-prolyl cis-trans isomerase FKBP | PPIase_FKBP | Family | 3,011 | true | false | This family of proteins functions as peptidyl-prolyl cis-trans isomerases (PPIases) that catalyze the isomerization of proline imidic peptide bonds in oligopeptides, which is a rate-limiting step in protein folding. These enzymes are known to facilitate the proper folding of proteins during synthesis. Members of this f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46222"
] | [
"PPIase_FKBP"
] | [
3011
] | 1 | [
"EC",
"REACTOME"
] | [
"5.2.1.8",
"R-HSA-381038"
] | [
"EC:5.2.1.8",
"REACTOME:R-HSA-381038"
] | 2 | [
"4dip",
"4msp"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"mine drainage metagenome"
] | [
2979,
31,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
11,
9,
7
] | 6 | true | Family | Peptidyl-prolyl cis-trans isomerase FKBP | Peptidyl-prolyl cis-trans isomerase FKBP | PPIase_FKBP | 8 |
IPR052274 | 52,274 | Krueppel-type C2H2 zinc-finger | Krueppel_C2H2_Zn-finger | Family | 2,807 | true | false | This family of proteins includes members that are likely to play a role in the regulation of gene expression. Each member contains C2H2-type zinc-finger motifs, which are commonly found in transcription factors. These motifs facilitate DNA binding, allowing the proteins to interact with specific gene promoter regions a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22979"
] | [
"Krueppel_C2H2_Zn-finger"
] | [
2807
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013424",
"R-MMU-9013424"
] | [
"REACTOME:R-HSA-9013424",
"REACTOME:R-MMU-9013424"
] | 2 | [
"2ctd",
"2gqj"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2807
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
7,
10,
9
] | 4 | true | Family | Krueppel-type C2H2 zinc-finger | Krueppel-type C2H2 zinc-finger | Krueppel_C2H2_Zn-finger | 2 |
IPR052275 | 52,275 | Mitochondrial Fe-S cluster assembly factor | Mt_Fe-S_assembly_factor | Family | 2,864 | true | false | This family of proteins functions as mitochondrial iron-sulfur (Fe-S) cluster assembly factors. They are involved in the insertion of [4Fe-4S] clusters into a subset of mitochondrial proteins, such as lipoyl synthase and succinate dehydrogenase. These proteins operate in the final step of the Fe-S protein assembly proc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46188"
] | [
"Mt_Fe-S_assembly_factor"
] | [
2864
] | 1 | [] | [] | [] | 0 | [
"2ncl"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Rickettsiales"
] | [
2860,
4
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2,
5,
1,
3,
1,
1
] | 8 | true | Family | Mitochondrial Fe-S cluster assembly factor | Mitochondrial Fe-S cluster assembly factor | Mt_Fe-S_assembly_factor | 3 |
IPR052276 | 52,276 | Diphthamide biosynthesis and chaperone domain-containing protein | Diphthamide-biosynth_chaperone | Family | 2,968 | true | false | This family of proteins is involved in diverse cellular processes, including post-translational modification and molecular chaperoning. One member is essential for diphthamide biosynthesis, a unique modification of histidine in elongation factor 2, which is crucial for accurate protein synthesis. Another member functio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44240"
] | [
"Diphthamide-biosynth_chaperone"
] | [
2968
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megamimivirinae",
"metagenomes"
] | [
174,
810,
1961,
3,
20
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
7,
7
] | 3 | true | Family | Diphthamide biosynthesis and chaperone domain-containing protein | Diphthamide biosynthesis and chaperone domain-containing protein | Diphthamide-biosynth_chaperone | 1 |
IPR052277 | 52,277 | Inner Nuclear Membrane ESCRT-Associated Protein | INM_ESCRT-Associated | Family | 2,700 | true | false | This family of proteins is associated with the inner nuclear membrane and plays a crucial role in nuclear structure organization, maintenance of nuclear envelope integrity, and nuclear envelope reformation after mitosis. Members of this family function as transmembrane adapters for the ESCRT machinery, facilitating ESC... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13428"
] | [
"INM_ESCRT-Associated"
] | [
2700
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2980766",
"R-HSA-2995383",
"R-HSA-4419969",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013405",
"R-HSA-9013408",
"R-HSA-9013423",
"R-HSA-9668328",
"R-HSA-9696264",
"R-HSA-9696270",
"R-HSA-9696273"
] | [
"REACTOME:R-HSA-2980766",
"REACTOME:R-HSA-2995383",
"REACTOME:R-HSA-4419969",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013405",
"REACTOME:R-HSA-9013408",
"REACTOME:R-HSA-9013423",
"REACTOME:R-HSA-9668328",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOM... | 12 | [
"2ch0",
"5zoj",
"5zok"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
2697
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
10,
5,
7
] | 6 | true | Family | Inner Nuclear Membrane ESCRT-Associated Protein | Inner Nuclear Membrane ESCRT-Associated Protein | INM_ESCRT-Associated | 7 |
IPR052278 | 52,278 | Chordin-like dorsalizing regulators | Chordin-like_regulators | Family | 2,567 | true | false | This family of proteins includes dorsalizing factors that play a crucial role in early vertebrate embryogenesis. They are involved in the regulation of developmental processes by binding to and sequestering TGF-beta family bone morphogenetic proteins (BMPs), which are known as ventralizing factors. By forming latent co... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46526"
] | [
"Chordin-like_regulators"
] | [
2567
] | 1 | [] | [] | [] | 0 | [
"1u5m",
"5nir"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
129,
2437,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
10,
7,
5
] | 5 | true | Family | Chordin-like dorsalizing regulators | Chordin-like dorsalizing regulators | Chordin-like_regulators | 3 |
IPR052279 | 52,279 | EngB GTPase | EngB_GTPase | Family | 2,697 | true | false | The EngB GTPase family is part of the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Members of the EngB GTPase family, such as GTP-binding protein 8, are involved in various cellular processes due to their ability to bind and hydrolyze GTP. One of the family members is known to be a component of MIORE... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46498"
] | [
"EngB_GTPase"
] | [
2697
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
3,
2692,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
5,
4,
1,
4,
1
] | 6 | true | Family | EngB GTPase | EngB GTPase | EngB_GTPase | 5 |
IPR052280 | 52,280 | HEPACAM domain-containing protein | HEPACAM_domain | Family | 2,484 | true | false | This family of proteins is involved in various cellular processes including cell-matrix adhesion, cell motility, and cell proliferation. Some members play a crucial role during prometaphase of cell division by ensuring centrosome maturation, which is vital for proper chromosome segregation. They facilitate the transloc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44888"
] | [
"HEPACAM_domain"
] | [
2484
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2484
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
5,
9
] | 4 | true | Family | HEPACAM domain-containing protein | HEPACAM domain-containing protein | HEPACAM_domain | 3 |
IPR052281 | 52,281 | GRB2-associated and regulator of MAPK | GAREM | Family | 2,885 | true | false | The GAREM family consists of adapter proteins that play a crucial role in the intracellular signaling pathways initiated by the activation of the epidermal growth factor receptor (EGFR) on the cell surface or by cytoplasmic protein tyrosine kinases. Members of this family are involved in promoting the activation of the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14454"
] | [
"GAREM"
] | [
2885
] | 1 | [] | [] | [] | 0 | [
"2dkz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2885
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
3,
2,
7
] | 5 | true | Family | GRB2-associated and regulator of MAPK | GRB2-associated and regulator of MAPK | GAREM | 8 |
IPR052282 | 52,282 | Starch-active lytic polysaccharide monooxygenase | Starch-active_LPMO | Family | 2,611 | true | false | This family of proteins includes enzymes known as lytic polysaccharide monooxygenases (LPMOs) that are involved in the oxidative cleavage of polysaccharides. They are characterized by their ability to act on starch substrates by oxidizing the C1 position. These proteins typically contain a carbohydrate-binding module 2... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36575"
] | [
"Starch-active_LPMO"
] | [
2611
] | 1 | [
"EC"
] | [
"1.14.99.55"
] | [
"EC:1.14.99.55"
] | 1 | [
"4opb",
"5lsv",
"5t7j",
"5t7k",
"5t7n",
"6tbq",
"6tbr",
"6tc4",
"7ze9"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
2610,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Starch-active lytic polysaccharide monooxygenase | Starch-active lytic polysaccharide monooxygenase | Starch-active_LPMO | 3 |
IPR052283 | 52,283 | Genomic Stability and Neuronal Morphogenesis Regulator | GenomicStab_NeuMorph_Reg | Family | 2,684 | true | false | This family of proteins is involved in various cellular processes related to neurogenesis, neuronal morphology, and genomic stability. Members of this family contribute to the differentiation of oligodendrocytes and the morphogenesis of basket cells in the cortex during development. They play a role in the formation an... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15739"
] | [
"GenomicStab_NeuMorph_Reg"
] | [
2684
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2684
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
3,
4,
5,
8
] | 5 | true | Family | Genomic Stability and Neuronal Morphogenesis Regulator | Genomic Stability and Neuronal Morphogenesis Regulator | GenomicStab_NeuMorph_Reg | 8 |
IPR052284 | 52,284 | Collagen-modifying leprecan protein | Collagen_mod_leprecan | Family | 2,524 | true | false | This family of proteins is involved in the post-translational modification of collagen, specifically in the hydroxylation of prolyl and lysine residues within collagen alpha chains. These modifications are crucial for the proper assembly and cross-linking of collagen fibrils, which are essential for maintaining the str... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13986"
] | [
"Collagen_mod_leprecan"
] | [
2524
] | 1 | [
"REACTOME"
] | [
"R-HSA-1650814"
] | [
"REACTOME:R-HSA-1650814"
] | 1 | [
"8k0e",
"8k0f",
"8k0i",
"8k0m",
"8k17",
"8kc9"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2524
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
10,
18,
6,
9
] | 5 | true | Family | Collagen-modifying leprecan protein | Collagen-modifying leprecan protein | Collagen_mod_leprecan | 8 |
IPR052285 | 52,285 | Nuclear exosome targeting complex subunit | NEXT_complex_subunit | Family | 2,723 | true | false | This family of proteins includes RNA-binding subunits of the nuclear exosome targeting (NEXT) complex, which functions as an RNA exosome cofactor. They are involved in the surveillance and turnover of a subset of non-coding short-lived RNAs, including aberrant transcripts. These proteins bind preferentially to polyurid... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13798"
] | [
"NEXT_complex_subunit"
] | [
2723
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-BTA-9930044",
"R-HSA-72163",
"R-HSA-9843970",
"R-HSA-9930044",
"R-MMU-72163",
"R-MMU-9930044"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-9930044",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-9843970",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-9930044"
] | 7 | [
"2m8h",
"2ywk",
"5iqq",
"5lsl",
"5lxr",
"5lxy",
"7s7b",
"7s7c"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2723
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
2,
4,
3,
9,
6,
7,
10,
24
] | 9 | true | Family | Nuclear exosome targeting complex subunit | Nuclear exosome targeting complex subunit | NEXT_complex_subunit | 3 |
IPR052287 | 52,287 | Non-homologous end-joining factor | NHEJ_factor | Family | 2,515 | true | false | This family of proteins is involved in the DNA damage response, specifically in the repair of double-strand breaks (DSBs) through the non-homologous end joining (NHEJ) pathway. Members of this family play a crucial role in maintaining genomic stability by facilitating the ligation of DSBs, which can arise from various ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32235"
] | [
"NHEJ_factor"
] | [
2515
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5693571",
"R-MMU-5693571",
"R-RNO-5693571"
] | [
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-5693571",
"REACTOME:R-RNO-5693571"
] | 3 | [
"2qm4",
"2r9a",
"3q4f",
"3rwr",
"3sr2",
"3w03",
"7lsy",
"7lt3",
"7nfc",
"7nfe",
"7zyg",
"8bhv",
"8bhy",
"8bot",
"8eza",
"8ezb",
"9cq3",
"9cq6",
"9cqc",
"9n81",
"9n82",
"9n83"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2515
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
6,
2,
1,
4,
1
] | 6 | true | Family | Non-homologous end-joining factor | Non-homologous end-joining factor | NHEJ_factor | 1 |
IPR052288 | 52,288 | Glycosyl Hydrolase 45 Enzymes | GH45_Enzymes | Family | 2,138 | true | false | This family of proteins includes enzymes that catalyze the endohydrolysis of 1,4-beta-glucosidic linkages in various substrates such as cellulose, lichenin, and cereal beta-D-glucans. Members of this family are characterized by their ability to break down complex carbohydrates into simpler sugars, with a preference for... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39730"
] | [
"GH45_Enzymes"
] | [
2138
] | 1 | [
"EC",
"METACYC"
] | [
"3.2.1.4",
"PWY-6788"
] | [
"EC:3.2.1.4",
"METACYC:PWY-6788"
] | 2 | [
"1hd5",
"1l8f",
"1oa7",
"1oa9",
"2eng",
"3eng",
"4eng",
"5glx",
"5gly",
"5gm9",
"5h4u",
"6mvi",
"6mvj"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
47,
2089,
2
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glycosyl Hydrolase 45 Enzymes | Glycosyl Hydrolase 45 Enzymes | GH45_Enzymes | 1 |
IPR052290 | 52,290 | Sphingolipid C9-methyltransferase | Sphingo_C9-MT | Family | 2,350 | true | false | This family of proteins catalyzes the methylation of the sphingoid base component of glucosylceramides at the C9-position. The specific activity involves the use of 4,8-desaturated ceramides as substrates. These enzymes play a pivotal role in the growth, differentiation, and pathogenicity of fungi. The addition of a me... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45197"
] | [
"Sphingo_C9-MT"
] | [
2350
] | 1 | [
"EC"
] | [
"2.1.1.317"
] | [
"EC:2.1.1.317"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample"
] | [
27,
2322,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Sphingolipid C9-methyltransferase | Sphingolipid C9-methyltransferase | Sphingo_C9-MT | 6 |
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