interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052292 | 52,292 | Glucose repression regulatory protein | Glucose_repression_reg | Family | 2,452 | true | false | This family of proteins is involved in various cellular processes including RNA processing and the regulation of glucose repression. Members of this family have been shown to interact with protein phosphatases and kinases, suggesting a role in signal transduction pathways that influence cell growth and metabolism. Some... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28051"
] | [
"Glucose_repression_reg"
] | [
2452
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ornithinibacillus caprae"
] | [
2451,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
3,
1
] | 3 | true | Family | Glucose repression regulatory protein | Glucose repression regulatory protein | Glucose_repression_reg | 1 |
IPR052293 | 52,293 | Serine-Rich Repeat Protein (SRRP) | SRRP | Family | 913 | true | false | The Serine-Rich Repeat Protein (SRRP) family is characterized by its involvement in host-pathogen interactions, particularly in bacterial species. Members of the SRRP family are known to possess serine-rich regions that contribute to their function in mediating adhesion to host cell glycoproteins, such as human platele... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12239"
] | [
"SRRP"
] | [
913
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"viral metagenome"
] | [
182,
3,
726,
2
] | 4 | [] | [] | 0 | true | Family | Serine-Rich Repeat Protein (SRRP) | Serine-Rich Repeat Protein (SRRP) | SRRP | 5 |
IPR052294 | 52,294 | Visual system homeobox transcriptional regulators | VSX_homeobox_regulators | Family | 2,500 | true | false | The Visual system homeobox family comprises transcriptional regulators involved in the development and differentiation of various neuronal cell types and eye structures. Family members mediate the differentiation of V2a interneurons and play roles in eye development, including the specification and morphogenesis of the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46892"
] | [
"VSX_homeobox_regulators"
] | [
2500
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2500
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
5,
13,
3,
4
] | 6 | true | Family | Visual system homeobox transcriptional regulators | Visual system homeobox transcriptional regulators | VSX_homeobox_regulators | 1 |
IPR052295 | 52,295 | Odorant-binding protein | Odorant-binding_protein | Family | 2,219 | true | true | This family of proteins is found in insects and it is involved in the olfactory system, specifically in the capture and transport of hydrophobic odorant molecules. Members of this family are thought to be present in the fluid surrounding olfactory sensory dendrites, where they play a role in transporting these odorants... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21066"
] | [
"Odorant-binding_protein"
] | [
2219
] | 1 | [] | [] | [] | 0 | [
"3pm2",
"4ij7",
"4kyn"
] | 3 | [
"PUB00154133",
"PUB00154598"
] | [
"21561433",
"30230472"
] | [
"Crystal structure of a novel type of odorant-binding protein from Anopheles gambiae, belonging to the C-plus class.",
"Humidity response depends on the small soluble protein Obp59a in <i>Drosophila</i>."
] | [
2011,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Pterygota"
] | [
2219
] | 1 | [
"Drosophila melanogaster"
] | [
24
] | 1 | true | Family | Odorant-binding protein | Odorant-binding protein | Odorant-binding_protein | 2 |
IPR052296 | 52,296 | Transcriptional Repressor and Histone Methyltransferase | TR-Histone_Methyltrans | Family | 2,035 | true | false | This family of proteins includes transcriptional repressors and histone methyltransferases. Members are involved in various biological processes such as neural development, neuronal differentiation, and steroidogenesis. Some proteins in this family act on histone H3 lysine residues, modifying chromatin structure and in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16516"
] | [
"TR-Histone_Methyltrans"
] | [
2035
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 147 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2035
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
4,
2,
5
] | 6 | true | Family | Transcriptional Repressor and Histone Methyltransferase | Transcriptional Repressor and Histone Methyltransferase | TR-Histone_Methyltrans | 2 |
IPR052297 | 52,297 | RING-CH-type E3 ubiquitin-protein ligase | RING-CH-type_E3_ubiq-ligase | Family | 2,125 | true | false | This family of proteins includes E3 ubiquitin-protein ligases with a RING-CH-type zinc finger domain essential for their ligase activity. These enzymes facilitate the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to specific substrate proteins, thereby tagging them for various cellular processes. The ubiq... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14471"
] | [
"RING-CH-type_E3_ubiq-ligase"
] | [
2125
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
2125
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
14,
6,
15
] | 4 | true | Family | RING-CH-type E3 ubiquitin-protein ligase | RING-CH-type E3 ubiquitin-protein ligase | RING-CH-type_E3_ubiq-ligase | 2 |
IPR052298 | 52,298 | Zinc finger MYND domain-containing protein 10 | ZMYND10 | Family | 2,134 | true | false | The ZMYND10 family is implicated in the organization and motility of axonemal structures, which are essential components of cilia. Family members play a crucial role in the pre-assembly of inner and outer dynein arms, which are necessary for the proper construction of the axoneme, the core structure of cilia responsibl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13244"
] | [
"ZMYND10"
] | [
2134
] | 1 | [] | [] | [] | 0 | [
"2d8q",
"2dan"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2134
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
1,
3
] | 5 | true | Family | Zinc finger MYND domain-containing protein 10 | Zinc finger MYND domain-containing protein 10 | ZMYND10 | 6 |
IPR052299 | 52,299 | Centrosomal protein of 76 kDa | CEP76 | Family | 2,100 | true | false | The CEP76 family comprises centrosomal proteins that play a crucial role in ensuring proper centriole duplication. Members of the CEP76 family are essential for maintaining the fidelity of cell division by restricting centriole duplication to a single event per cell cycle, thereby preventing centriole reduplication. Th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46436"
] | [
"CEP76"
] | [
2100
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-XTR-2565942",
"R-XTR-380259",
"R-XTR-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 20 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Sulfurimonas diazotrophicus"
] | [
2099,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
1,
6
] | 4 | true | Family | Centrosomal protein of 76 kDa | Centrosomal protein of 76 kDa | CEP76 | 9 |
IPR052300 | 52,300 | Adhesion and Centrosome-associated Protein | Adhesion_Centrosome_assoc | Family | 2,272 | true | false | This family of proteins is involved in cellular adhesion systems, contributing to the organization of various types of cell-cell adherens junctions, including homotypic, interneuronal, and heterotypic connections. Members of this family may facilitate the linkage between the nectin-afadin and E-cadherin-catenin systems... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46507"
] | [
"Adhesion_Centrosome_assoc"
] | [
2272
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2272
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
7,
4,
5
] | 4 | true | Family | Adhesion and Centrosome-associated Protein | Adhesion and Centrosome-associated Protein | Adhesion_Centrosome_assoc | 1 |
IPR052301 | 52,301 | SCF Complex F-box/Wd Repeat-Containing Protein | SCF_F-box/WD-repeat | Family | 2,007 | true | false | This family of proteins includes components of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which are involved in the recognition and binding of specific substrate proteins, often following phosphorylation. These proteins facilitate the ubiquitination and subsequent proteasomal degradation of their ta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14381"
] | [
"SCF_F-box/WD-repeat"
] | [
2007
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-390471",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-SCE-983168"
] | [
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-SCE-983168"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2007
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
2,
9,
7,
6,
2
] | 6 | true | Family | SCF Complex F-box/Wd Repeat-Containing Protein | SCF Complex F-box/Wd Repeat-Containing Protein | SCF_F-box/WD-repeat | 7 |
IPR052302 | 52,302 | Neurotrophin receptor-related death domain-containing protein | Neurotrophin_rcpt-DD | Family | 2,055 | true | false | This family of proteins includes receptors that modulate signaling pathways for cell survival, differentiation, and apoptosis. They interact with neurotrophins such as NGF, BDNF, NTF3, and NTF4, with varying affinities for mature and precursor forms. Members of this family can form heterodimeric complexes, influencing ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46605"
] | [
"Neurotrophin_rcpt-DD"
] | [
2055
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-193692",
"R-GGA-205017",
"R-GGA-205043",
"R-GGA-209543",
"R-GGA-209560",
"R-GGA-209563",
"R-HSA-193634",
"R-HSA-193648",
"R-HSA-193670",
"R-HSA-193681",
"R-HSA-193692",
"R-HSA-205017",
"R-HSA-205025",
"R-HSA-205043",
"R-HSA-209543",
"R-HSA-209560",
"R-HSA-209563",
"R-MMU-193... | [
"REACTOME:R-GGA-193692",
"REACTOME:R-GGA-205017",
"REACTOME:R-GGA-205043",
"REACTOME:R-GGA-209543",
"REACTOME:R-GGA-209560",
"REACTOME:R-GGA-209563",
"REACTOME:R-HSA-193634",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-193670",
"REACTOME:R-HSA-193681",
"REACTOME:R-HSA-193692",
"REACTOME:R-HSA-205... | 33 | [
"1ngr",
"1sg1",
"2ib1",
"2mic",
"2mjo",
"2n80",
"2n83",
"2n97",
"3buk",
"3ij2",
"4f42",
"4f44",
"5zgg",
"6hj7",
"7csq",
"8x8t"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2055
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
9,
8
] | 4 | true | Family | Neurotrophin receptor-related death domain-containing protein | Neurotrophin receptor-related death domain-containing protein | Neurotrophin_rcpt-DD | 9 |
IPR052303 | 52,303 | Cardiac-enriched FHL2-interacting | CEFIP | Family | 2,081 | true | false | This family of proteins is implicated in the regulation of cardiomyocyte hypertrophy. Members are known to interact with the FHL2 protein and play a significant role in the activation of the calcineurin/NFAT signaling pathway, which is crucial for cardiac muscle cell growth and function. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33775"
] | [
"CEFIP"
] | [
2081
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ball python nidovirus",
"Eukaryota"
] | [
1,
2080
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
6,
4,
4
] | 4 | true | Family | Cardiac-enriched FHL2-interacting | Cardiac-enriched FHL2-interacting | CEFIP | 2 |
IPR052305 | 52,305 | Transcriptional Regulators and Tumor Expansion | TransReg_TumorExp | Family | 1,997 | true | false | The protein family is involved in various cellular processes including transcriptional regulation and tumor cell expansion. Members act as transcriptional coactivators, enhancing the activity of MEF2C and MYOD1, which are crucial for skeletal muscle differentiation. Additionally, they play a role in down-regulating spe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23251"
] | [
"TransReg_TumorExp"
] | [
1997
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Kangiella spongicola",
"Vertebrata"
] | [
1,
1996
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
6,
12,
11
] | 4 | true | Family | Transcriptional Regulators and Tumor Expansion | Transcriptional Regulators and Tumor Expansion | TransReg_TumorExp | 3 |
IPR052306 | 52,306 | Cytochrome P450 71D | CYP450_71D | Family | 5,239 | true | false | The Cytochrome P450 71D family comprises enzymes with monooxygenase activity, involved in the biosynthesis of various phytoalexins, which are antimicrobial and often antioxidative substances produced by plants in response to pathogen attack. Members of the family catalyze hydroxylation reactions, adding hydroxyl groups... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47953"
] | [
"CYP450_71D"
] | [
5239
] | 1 | [
"EC"
] | [
"1.14.14"
] | [
"EC:1.14.14"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spermatophyta"
] | [
5239
] | 1 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
47,
19
] | 2 | true | Family | Cytochrome P450 71D | Cytochrome P450 71D | CYP450_71D | 6 |
IPR052307 | 52,307 | Epithelial Junction Adhesion Regulator | EJ_Adhesion_Regulator | Family | 1,833 | true | false | This family of proteins is involved in cellular adhesion and integrity, particularly in the formation and maintenance of tight junctions in epithelial cells. They play a crucial role in the epithelial apical junction complex and are implicated in the transepithelial migration of leukocytes. These proteins interact with... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44468"
] | [
"EJ_Adhesion_Regulator"
] | [
1833
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-198933",
"R-BTA-202733",
"R-DRE-198933",
"R-DRE-202733",
"R-HSA-198933",
"R-HSA-202733",
"R-MMU-198933",
"R-MMU-202733",
"R-RNO-198933",
"R-RNO-202733"
] | [
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-202733",
"REACTOME:R-DRE-198933",
"REACTOME:R-DRE-202733",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202733",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-202733",
"REACTOME:R-RNO-198933",
"REACTOME:R-RNO-202733"
] | 10 | [
"1eaj",
"1f5w",
"1jew",
"1kac",
"1p69",
"1p6a",
"1rsf",
"2j12",
"2j1k",
"2npl",
"2w9l",
"2wbw",
"3j6l",
"3j6m",
"3j6n",
"3j6o",
"3jz7",
"3mj7",
"7dpz",
"7dq1",
"7vxz",
"7vyk",
"7vyl",
"7vym",
"7w14"
] | 25 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1833
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
5,
7
] | 4 | true | Family | Epithelial Junction Adhesion Regulator | Epithelial Junction Adhesion Regulator | EJ_Adhesion_Regulator | 1 |
IPR052308 | 52,308 | Pentatricopeptide repeat domain-containing protein | PPR_domain-containing | Family | 2,204 | true | false | This family of proteins features the pentatricopeptide repeat (PPR), which is a sequence motif known to mediate sequence-specific RNA binding. Members of this family are implicated in post-transcriptional processes within organelles, such as RNA editing, stability, and processing. The PPR motif typically consists of 35... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47937"
] | [
"PPR_domain-containing"
] | [
2204
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
2201
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
22,
13,
13
] | 3 | true | Family | Pentatricopeptide repeat domain-containing protein | Pentatricopeptide repeat domain-containing protein | PPR_domain-containing | 5 |
IPR052310 | 52,310 | Kelch/BTB domain-containing protein | Kelch/BTB_domain_protein | Family | 1,586 | true | false | This family of proteins includes members that contain Kelch motifs, which are typically involved in protein-protein interactions, and may also feature BTB/POZ domains that participate in protein oligomerization and interactions with other cellular components. These domains are often found in proteins that play roles in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45972"
] | [
"Kelch/BTB_domain_protein"
] | [
1586
] | 1 | [] | [] | [] | 0 | [
"7on6",
"7ona"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
1584
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
7,
5,
8
] | 4 | true | Family | Kelch/BTB domain-containing protein | Kelch/BTB domain-containing protein | Kelch/BTB_domain_protein | 4 |
IPR052311 | 52,311 | MMS22L-TONSL complex component | MMS22L-TONSL_complex_comp | Family | 1,853 | true | false | This family of proteins is involved in the maintenance of genome integrity during DNA replication by promoting homologous recombination-mediated repair of double-strand breaks at stalled or collapsed replication forks. Members of this family are components of the MMS22L-TONSL complex, which is essential for the assembl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46358"
] | [
"MMS22L-TONSL_complex_comp"
] | [
1853
] | 1 | [] | [] | [] | 0 | [
"5ja4",
"9wvh",
"9wvi"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"bird metagenome"
] | [
1846,
5,
2
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
5,
1
] | 5 | true | Family | MMS22L-TONSL complex component | MMS22L-TONSL complex component | MMS22L-TONSL_complex_comp | 3 |
IPR052313 | 52,313 | Platelet Glycoprotein Ib-IX-V Complex | GPIb-IX-V_Complex | Family | 1,880 | true | false | The Platelet Glycoprotein Ib-IX-V Complex family comprises proteins that play a crucial role in hemostasis. Members of this family, including GPIb alpha, GPIb beta, GPIX, and GPV, form a receptor complex on the surface of platelets. This complex binds to von Willebrand factor (vWF), facilitating platelet adhesion to da... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22650"
] | [
"GPIb-IX-V_Complex"
] | [
1880
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140837",
"R-HSA-430116",
"R-HSA-75892",
"R-HSA-76009",
"R-HSA-9673221",
"R-HSA-9845620",
"R-HSA-9846298",
"R-MMU-140837",
"R-MMU-430116",
"R-MMU-75892",
"R-MMU-76009",
"R-RNO-140837",
"R-RNO-430116",
"R-RNO-76009"
] | [
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-430116",
"REACTOME:R-HSA-75892",
"REACTOME:R-HSA-76009",
"REACTOME:R-HSA-9673221",
"REACTOME:R-HSA-9845620",
"REACTOME:R-HSA-9846298",
"REACTOME:R-MMU-140837",
"REACTOME:R-MMU-430116",
"REACTOME:R-MMU-75892",
"REACTOME:R-MMU-76009",
"REACTOME:R-RNO-1408... | 14 | [
"3rez",
"3rfe",
"6bxc",
"6bxe",
"8wfs"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1880
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
11,
3,
3
] | 4 | true | Family | Platelet Glycoprotein Ib-IX-V Complex | Platelet Glycoprotein Ib-IX-V Complex | GPIb-IX-V_Complex | 4 |
IPR052314 | 52,314 | Immune receptor domain-containing protein | Immune_rcpt_domain | Family | 2,002 | true | false | This family of proteins is involved in immune system processes, including the innate and adaptive immune responses. Members act as cell surface receptors that can enhance T-cell activation, regulate Toll-like receptor signaling, and mediate cytokine production. Some proteins in the family are implicated in the regulati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16423"
] | [
"Immune_rcpt_domain"
] | [
2002
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-2172127",
"R-HSA-2424491",
"R-HSA-416700",
"R-MMU-198933",
"R-MMU-2172127",
"R-MMU-2424491",
"R-MMU-416700"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-2172127",
"REACTOME:R-HSA-2424491",
"REACTOME:R-HSA-416700",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-2172127",
"REACTOME:R-MMU-2424491",
"REACTOME:R-MMU-416700"
] | 8 | [
"1hkf",
"2frg",
"5eli",
"5ud7",
"5ud8",
"6b8o",
"6y6c",
"6ymq",
"6yye"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2002
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
23,
18
] | 3 | true | Family | Immune receptor domain-containing protein | Immune receptor domain-containing protein | Immune_rcpt_domain | 1 |
IPR052315 | 52,315 | MORN repeat-containing protein 4 | MORN4 | Family | 1,532 | true | false | The MORN repeat-containing protein 4 family is characterized by its role in neuronal response to injury. Members of this family are implicated in the promotion of axonal degeneration following neuronal damage due to toxic insult or trauma. In addition to this conserved function, the Drosophila homolog has a specialized... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46614"
] | [
"MORN4"
] | [
1532
] | 1 | [] | [] | [] | 0 | [
"6jle"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
57,
1473,
2
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
1,
3
] | 5 | true | Family | MORN repeat-containing protein 4 | MORN repeat-containing protein 4 | MORN4 | 4 |
IPR052316 | 52,316 | Speedy/Ringo cell cycle regulator | Speedy-Ringo_regulator | Family | 1,509 | true | false | This family of proteins is involved in the regulation of cell cycle progression, particularly the G1/S phase transition and meiotic G2/M progression. Members of this family bind and activate cyclin-dependent kinases (CDK1 and CDK2), facilitating cell cycle transitions without promoting CDK2 phosphorylation. They induce... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31545"
] | [
"Speedy-Ringo_regulator"
] | [
1509
] | 1 | [] | [] | [] | 0 | [
"5uq1",
"5uq2",
"5uq3",
"7e34"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1509
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
3,
3
] | 4 | true | Family | Speedy/Ringo cell cycle regulator | Speedy/Ringo cell cycle regulator | Speedy-Ringo_regulator | 1 |
IPR052317 | 52,317 | Viral replication and host interaction regulator | Viral_replicn-host_int_reg | Family | 1,436 | true | false | This family of proteins includes multifunctional components involved in various cellular and viral processes. Members of this family play essential roles in virus replication cycles, acting as viroporins to form ion conductive pores, altering cell permeability, and facilitating ion and small molecule transport. They ar... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44665"
] | [
"Viral_replicn-host_int_reg"
] | [
1436
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pestivirus"
] | [
1389,
47
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
2,
10,
4,
3
] | 6 | true | Family | Viral replication and host interaction regulator | Viral replication and host interaction regulator | Viral_replicn-host_int_reg | 1 |
IPR052319 | 52,319 | Centriolar and ciliogenesis-associated protein | Centriolar_ciliogenesis_assoc | Family | 1,378 | true | false | This family of proteins is involved in the process of ciliogenesis, which is the formation of cilia on the surface of cells. Cilia are small, hair-like structures that protrude from the cell body and are involved in movement and sensory functions. Members of this family are essential for the proper anchoring of centrio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34174"
] | [
"Centriolar_ciliogenesis_assoc"
] | [
1378
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1378
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
2,
3
] | 5 | true | Family | Centriolar and ciliogenesis-associated protein | Centriolar and ciliogenesis-associated protein | Centriolar_ciliogenesis_assoc | 7 |
IPR052320 | 52,320 | Cytochrome b5 domain-containing | Cytochrome_b5_domain | Family | 1,267 | true | false | The cytochrome b5 family is characterized by a domain that binds heme under oxidizing conditions. Members of this family are involved in redox signaling pathways and are essential for the coordinated beating of multiple cilia. The cytochrome b5 domain-containing proteins function as radial spoke stalk proteins, which a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21281"
] | [
"Cytochrome_b5_domain"
] | [
1267
] | 1 | [] | [] | [] | 0 | [
"7jtk",
"8glv",
"8j07",
"9e5c",
"9fqr"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1267
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
1,
5
] | 5 | true | Family | Cytochrome b5 domain-containing | Cytochrome b5 domain-containing | Cytochrome_b5_domain | 6 |
IPR052321 | 52,321 | Polyamine Binding and Protein Trafficking | PolyBind_ProtTraffic | Family | 1,460 | true | false | The protein family includes members that are involved in polyamine binding and protein trafficking. Some members, like the prostatic spermine-binding proteins from mouse and rat, are glycoproteins that bind various polyamines and are regulated by androgens in the prostate. These proteins are functionally equivalent acr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33589"
] | [
"PolyBind_ProtTraffic"
] | [
1460
] | 1 | [] | [] | [] | 0 | [
"3apa",
"3aqg",
"3vy6",
"3vy7",
"3vze",
"3vzf",
"3vzg",
"3wob",
"3woc",
"7o3i",
"7o4p",
"7o88"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
17,
1443
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
23,
13
] | 3 | true | Family | Polyamine Binding and Protein Trafficking | Polyamine Binding and Protein Trafficking | PolyBind_ProtTraffic | 8 |
IPR052322 | 52,322 | Mitochondrial rRNA Methyltransferase NSUN4 | Mito_rRNA_Mtase_NSUN4 | Family | 485 | true | false | The NSUN4 family of proteins is involved in the biogenesis and assembly of mitochondrial ribosomes. Members of this family are 5-methylcytosine rRNA methyltransferases that play a crucial role in the maturation of the mitochondrial ribosome small subunit (SSU) by methylating 12S rRNA, as well as potentially methylating... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46955"
] | [
"Mito_rRNA_Mtase_NSUN4"
] | [
485
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
485
] | 1 | [
"Caenorhabditis elegans"
] | [
16
] | 1 | true | Family | Mitochondrial rRNA Methyltransferase NSUN4 | Mitochondrial rRNA Methyltransferase NSUN4 | Mito_rRNA_Mtase_NSUN4 | 7 |
IPR052323 | 52,323 | LRP2-binding protein | LRP2-binding | Family | 971 | true | false | This family of proteins may be involved in the regulation of LRP2, a multi-ligand receptor protein that plays a critical role in cellular uptake and signaling. The members of this family are thought to serve as adapter molecules that influence the function of LRP2, potentially affecting its interactions with various li... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44554"
] | [
"LRP2-binding"
] | [
971
] | 1 | [] | [] | [] | 0 | [
"9fqr"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
968,
3
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
6
] | 4 | true | Family | LRP2-binding protein | LRP2-binding protein | LRP2-binding | 5 |
IPR052324 | 52,324 | NFATC2-Interacting & DNA Repair | NFATC2-Int_DNA_Repair | Family | 1,037 | true | false | The NFATC2-interacting protein family is involved in the regulation of NFAT-driven transcription of cytokine genes in T-helper 2 (Th2) cells. Members of the family enhance cytokine expression by recruiting PRMT1 to promoters, facilitating histone methylation and acetylation. They also play a role in DNA repair by stabi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47187"
] | [
"NFATC2-Int_DNA_Repair"
] | [
1037
] | 1 | [] | [] | [] | 0 | [
"2jxx",
"2l76",
"3a4r",
"3a4s",
"3rd2"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1037
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
4,
2,
2
] | 5 | true | Family | NFATC2-Interacting & DNA Repair | NFATC2-Interacting & DNA Repair | NFATC2-Int_DNA_Repair | 7 |
IPR052326 | 52,326 | Differentiation & Development-Associated Protein | Diff-Dev_Assoc_Protein | Family | 486 | true | false | This family of proteins is involved in cellular differentiation and development. Members of this family appear to play roles in the process of cell differentiation, which is crucial for the development of specialized cell types from more generic precursor cells. Additionally, some proteins within this family are implic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33459"
] | [
"Diff-Dev_Assoc_Protein"
] | [
486
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pithovirus sibericum"
] | [
10,
475,
1
] | 3 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Family | Differentiation & Development-Associated Protein | Differentiation & Development-Associated Protein | Diff-Dev_Assoc_Protein | 9 |
IPR052327 | 52,327 | Activin-responsive transcriptional regulator | Activin_resp_transcr_regulator | Family | 746 | true | false | This family of proteins functions as transcriptional activators, primarily involved in early developmental processes such as gastrulation and mesoderm specification. They recognize and bind to specific DNA sequences, facilitating the transcription of genes responsive to TGF-beta or activin signaling pathways. Members o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47316"
] | [
"Activin_resp_transcr_regulator"
] | [
746
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1181150",
"R-HSA-1502540",
"R-HSA-9754189",
"R-HSA-9796292"
] | [
"REACTOME:R-HSA-1181150",
"REACTOME:R-HSA-1502540",
"REACTOME:R-HSA-9754189",
"REACTOME:R-HSA-9796292"
] | 4 | [
"7yz7",
"7yza",
"7yzb",
"7yzc",
"7yzd",
"7yzg"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
746
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2,
3
] | 4 | true | Family | Activin-responsive transcriptional regulator | Activin-responsive transcriptional regulator | Activin_resp_transcr_regulator | 9 |
IPR052328 | 52,328 | Forkhead box transcription regulators | FOX_transcription_regulators | Family | 648 | true | false | This family of proteins includes transcription factors that can function as both activators and repressors. They are involved in the regulation of genes associated with cellular responses to oxidative stress, such as heat shock chaperones and antioxidant enzymes. Additionally, they play a crucial role in normal brain d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46789"
] | [
"FOX_transcription_regulators"
] | [
648
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
648
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
4,
4
] | 4 | true | Family | Forkhead box transcription regulators | Forkhead box transcription regulators | FOX_transcription_regulators | 5 |
IPR052329 | 52,329 | Ciliary Microtubule Inner Protein 2C | CIMIP2C | Family | 613 | true | false | This family of proteins includes ciliary microtubule inner proteins that are integral components of the dynein-decorated doublet microtubules within the cilia axoneme. They play a crucial role in the beating of motile cilia, which is essential for various physiological processes including fluid movement and cell locomo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34924"
] | [
"CIMIP2C"
] | [
613
] | 1 | [] | [] | [] | 0 | [
"7ung",
"8i7o",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8snb",
"9fqr"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
613
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
3
] | 4 | true | Family | Ciliary Microtubule Inner Protein 2C | Ciliary Microtubule Inner Protein 2C | CIMIP2C | 8 |
IPR052333 | 52,333 | Cystatin family, spermatogenesis-associated | Cystatin_spermatogenesis | Family | 244 | true | false | The cystatin family is characterized by its members' ability to inhibit cysteine proteases. These proteins are involved in various physiological processes, including protein catabolism and extracellular matrix remodeling. Some members of the cystatin family, such as Cystatin-12 and Cystatin-14, are suggested to have sp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47393"
] | [
"Cystatin_spermatogenesis"
] | [
244
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160294"
] | [
"12444065"
] | [
"Identification and characterization of testis- and epididymis-specific genes: cystatin SC and cystatin TE-1."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eutheria"
] | [
244
] | 1 | [
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7
] | 2 | true | Family | Cystatin family, spermatogenesis-associated | Cystatin family, spermatogenesis-associated | Cystatin_spermatogenesis | 6 |
IPR052334 | 52,334 | G8 domain-containing protein comF-like | G8_domain-comF-like | Family | 258 | true | false | This family of proteins is characterized by the presence of a G8 domain, which suggests a potential role in signal transduction or protein-protein interactions. Members of this family are implicated in cellular communication processes, although the exact molecular functions and biological roles may vary among individua... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47687"
] | [
"G8_domain-comF-like"
] | [
258
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Epstein-Barr virus (strain GD1)",
"Eukaryota"
] | [
5,
16,
237
] | 3 | [] | [] | 0 | true | Family | G8 domain-containing protein comF-like | G8 domain-containing protein comF-like | G8_domain-comF-like | 4 |
IPR052335 | 52,335 | Insulin-like regulatory peptides | Insulin-like_regulatory | Family | 203 | true | false | This family of proteins includes insulin-like peptides that are implicated in the regulation of synapse development at neuromuscular junctions and may influence aging processes. They are likely involved in the negative regulation of dauer formation in response to environmental conditions, acting through the daf-2/InsR ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33893"
] | [
"Insulin-like_regulatory"
] | [
203
] | 1 | [] | [] | [] | 0 | [
"2kji",
"8tk9",
"8tkt",
"8tku"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rhabditida"
] | [
203
] | 1 | [
"Caenorhabditis elegans"
] | [
22
] | 1 | true | Family | Insulin-like regulatory peptides | Insulin-like regulatory peptides | Insulin-like_regulatory | 4 |
IPR052336 | 52,336 | MlaD Inter-membrane Phospholipid Transporter | MlaD_Phospholipid_Transporter | Family | 53,708 | true | false | This family of proteins is involved in the maintenance of lipid asymmetry in bacterial outer membranes. Members function as part of an ABC transporter complex, which is essential for the retrograde trafficking of phospholipids from the outer to the inner membrane. These proteins have a high affinity for phospholipids a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33371"
] | [
"MlaD_Phospholipid_Transporter"
] | [
53708
] | 1 | [] | [] | [] | 0 | [
"5uw2",
"5uw8",
"6ic4",
"6xbd",
"6z5u",
"6zy2",
"6zy3",
"6zy4",
"6zy9",
"7ai2",
"7ai3",
"7cge",
"7cgn",
"7ch0",
"7ch8",
"7ch9",
"7cha",
"7d06",
"7d08",
"7d09",
"7d0a",
"8fed",
"8fee",
"8fef",
"8hpz",
"8hq9",
"8hqa",
"8oj4",
"8ojg"
] | 29 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
53265,
92,
351
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | MlaD Inter-membrane Phospholipid Transporter | MlaD Inter-membrane Phospholipid Transporter | MlaD_Phospholipid_Transporter | 3 |
IPR052337 | 52,337 | Satratoxin biosynthesis SC1 cluster protein 4-like | SAT4-like | Family | 78,477 | true | true | The Satratoxin biosynthesis SC1-like family is involved in the biosynthesis of various secondary metabolites with diverse biological activities. Members of the family are typically part of gene clusters that mediate the production of compounds such as wortmanamides, satratoxins, polyenoic acids, tetraketides fugralins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33048"
] | [
"SAT4_SecMetBiosynth"
] | [
78477
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092618",
"PUB00160332"
] | [
"22238661",
"36611796"
] | [
"The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi.",
"Upstream Regulation of Development and Secondary Metabolism in <i>Aspergillus</i> Species."
] | [
2012,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
78477
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
41
] | 1 | true | Family | Satratoxin biosynthesis SC1 cluster protein 4-like | Satratoxin biosynthesis SC1 cluster protein 4-like | SAT4-like | 8 |
IPR052338 | 52,338 | Transposase_5 | Transposase_5 | Family | 24,975 | true | false | This family of proteins includes transposases which are enzymes that catalyze the movement of transposable elements within the genome. Members of this family are responsible for recognizing specific DNA sequences at the ends of transposable elements and facilitating their excision and insertion into new genomic locatio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23022"
] | [
"Transposase_5"
] | [
24975
] | 1 | [] | [] | [] | 0 | [
"5cr4"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota",
"Sylvanvirus sp.",
"invertebrate metagenome"
] | [
24967,
6,
1,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster"
] | [
2,
2,
45
] | 3 | true | Family | Transposase_5 | Transposase_5 | Transposase_5 | 8 |
IPR052339 | 52,339 | Iron-Sulfur Protein Maturation MIP18 | Fe-S_Maturation_MIP18 | Family | 24,418 | true | false | The MIP18 family is involved in the maturation of iron-sulfur (Fe-S) proteins, functioning as Fe-S cluster carriers. Members of this family play a crucial role in various cellular processes by assisting in the assembly and repair of Fe-S clusters, which are vital cofactors for many enzymes. The family includes proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42831"
] | [
"Fe-S_Maturation_MIP18"
] | [
24418
] | 1 | [] | [] | [] | 0 | [
"1uwd",
"1wcj",
"2cu6",
"3cq1",
"3cq2",
"3cq3",
"3lno",
"5ird"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
766,
23203,
13,
436
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Iron-Sulfur Protein Maturation MIP18 | Iron-Sulfur Protein Maturation MIP18 | Fe-S_Maturation_MIP18 | 3 |
IPR052342 | 52,342 | Mesaconyl-CoA Hydratase/Beta-methylmalyl-CoA Dehydratase | MCH/BMMD | Family | 19,985 | true | false | This family of proteins is involved in various metabolic cycles related to the processing of Coenzyme A (CoA) derivatives. Members of this family catalyze the reversible hydration and dehydration of specific CoA-bound substrates. These enzymes play a role in the methylaspartate cycle, the ethylmalonyl-CoA pathway, and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43664"
] | [
"MCH/BMMD"
] | [
19985
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.2.1.148",
"PWY-5741",
"PWY-5744",
"PWY-6728",
"PWY-7854"
] | [
"EC:4.2.1.148",
"METACYC:PWY-5741",
"METACYC:PWY-5744",
"METACYC:PWY-6728",
"METACYC:PWY-7854"
] | 5 | [
"1q6w",
"2bi0",
"3exz",
"4e3e",
"4ffu",
"8hgn"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1300,
18348,
45,
292
] | 4 | [] | [] | 0 | true | Family | Mesaconyl-CoA Hydratase/Beta-methylmalyl-CoA Dehydratase | Mesaconyl-CoA Hydratase/Beta-methylmalyl-CoA Dehydratase | MCH/BMMD | 8 |
IPR052343 | 52,343 | Diverse Retrotransposon and Effector-Associated Protein | Retrotransposon-Effector_Assoc | Family | 10,297 | true | false | This family of proteins includes diverse elements such as retrovirus-related pol polyproteins, uncharacterized mitochondrial proteins, secreted RxLR effectors, and proteins associated with transposable elements. The retrovirus-related pol polyproteins are likely involved in the replication and mobilization of retrotran... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46890"
] | [
"Retrotransposon-Effector_Assoc"
] | [
10297
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
10295,
2
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
19,
33
] | 2 | true | Family | Diverse Retrotransposon and Effector-Associated Protein | Diverse Retrotransposon and Effector-Associated Protein | Retrotransposon-Effector_Assoc | 3 |
IPR052344 | 52,344 | Transposase-related protein | Transposase-related | Family | 23,331 | true | false | This family of proteins includes members that are related to transposases, which are enzymes that catalyze the movement of DNA segments within the genome. These proteins typically contain domains that facilitate the binding and cleavage of DNA, as well as the integration of the transposable element into new genomic loc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33678"
] | [
"Transposase-related"
] | [
23331
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes",
"plasmids"
] | [
658,
21964,
112,
9,
586,
2
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Transposase-related protein | Transposase-related protein | Transposase-related | 2 |
IPR052345 | 52,345 | Radiation response metalloprotease | Rad_response_metalloprotease | Family | 16,034 | true | false | This family of proteins includes metalloproteases that are central regulators in DNA repair and protection pathways, particularly in response to radiation stress. They exhibit site-specific proteolytic activity, cleaving and inactivating repressor proteins, which leads to the induction of gene expression necessary for ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43236"
] | [
"Rad_response_metalloprotease"
] | [
16034
] | 1 | [] | [] | [] | 0 | [
"3dte",
"3dti",
"3dtk",
"7t5t",
"8slm",
"8sln"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
91,
15625,
9,
86,
223
] | 5 | [] | [] | 0 | true | Family | Radiation response metalloprotease | Radiation response metalloprotease | Rad_response_metalloprotease | 8 |
IPR052347 | 52,347 | Isochorismatase Family Nicotinamidases | Isochorismatase_Nicotinamidase | Family | 16,913 | true | false | The Isochorismatase Family Nicotinamidases are enzymes that catalyze the deamidation of nicotinamide into nicotinate, a key step in the NAD(+) salvage pathway. This reaction is crucial for maintaining cellular NAD(+) levels, which is essential for various metabolic processes. Members of the family are also involved in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11080"
] | [
"Isochorismatase_Nicotinamidase"
] | [
16913
] | 1 | [
"EC",
"METACYC"
] | [
"3.5.1.19",
"PWY-5381"
] | [
"EC:3.5.1.19",
"METACYC:PWY-5381"
] | 2 | [
"1ilw",
"1im5",
"2h0r",
"2wt9",
"2wta",
"3pl1",
"3r2j",
"3v8e",
"9u8m"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
75,
13537,
3166,
24,
111
] | 5 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
1,
1,
1,
1,
1
] | 6 | true | Family | Isochorismatase Family Nicotinamidases | Isochorismatase Family Nicotinamidases | Isochorismatase_Nicotinamidase | 5 |
IPR052348 | 52,348 | Zinc-dependent_metallopeptidase_M50B | Metallopeptidase_M50B | Family | 10,584 | true | false | This family of proteins includes zinc metalloproteases that are characterized by their ability to hydrolyze peptide bonds in other proteins. Members of this family are typically involved in various cellular processes, including protein degradation, regulation of cell signaling pathways, and the modulation of membrane p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35864"
] | [
"Metallopeptidase_M50B"
] | [
10584
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.24.-",
"PWY-8119"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
731,
9480,
88,
285
] | 4 | [] | [] | 0 | true | Family | Zinc-dependent_metallopeptidase_M50B | Zinc-dependent_metallopeptidase_M50B | Metallopeptidase_M50B | 7 |
IPR052350 | 52,350 | Metallo-dependent Lactonases | Metallo-dep_Lactonases | Family | 12,759 | true | false | The Metallo-dependent Lactonases family comprises enzymes that catalyze the hydrolysis of various lactones to the corresponding carboxylate forms, playing a role in carbohydrate degradation pathways. Members of this family exhibit high substrate specificity for lactones derived from sugars such as L-rhamnono-1,4-lacton... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43569"
] | [
"Metallo-dep_Lactonases"
] | [
12759
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.1.1.120",
"PWY-8318",
"PWY-8444"
] | [
"EC:3.1.1.120",
"METACYC:PWY-8318",
"METACYC:PWY-8444"
] | 3 | [
"4dlf",
"4dlm",
"4dnm",
"4do7",
"6uvz"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
10777,
1632,
65,
285
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Metallo-dependent Lactonases | Metallo-dependent Lactonases | Metallo-dep_Lactonases | 2 |
IPR052351 | 52,351 | L-ornithine N(alpha)-acyltransferase | Ornithine_N-alpha-AT | Family | 12,174 | true | false | This family of proteins is involved in the biosynthesis of ornithine lipids, which are a type of phosphorus-free membrane lipid. Members of this family function as enzymes that catalyze the acylation of ornithine with a 3-hydroxyacyl moiety derived from an acyl carrier protein. This enzymatic activity results in the fo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37323"
] | [
"Ornithine_N-alpha-AT"
] | [
12174
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.30",
"PWY-6818"
] | [
"EC:2.3.2.30",
"METACYC:PWY-6818"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
12041,
9,
1,
123
] | 4 | [] | [] | 0 | true | Family | L-ornithine N(alpha)-acyltransferase | L-ornithine N(alpha)-acyltransferase | Ornithine_N-alpha-AT | 9 |
IPR052352 | 52,352 | Sugar Degradation Dehydratases | Sugar_Degrad_Dehydratases | Family | 12,193 | true | false | This family of proteins includes dehydratases that are involved in the degradation of various sugars and sugar derivatives. Members of this family catalyze the dehydration of specific substrates such as D-xylonate, L-arabinonate, and 6-deoxy-6-sulfo-D-gluconate, leading to the formation of their respective dehydrated p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43183"
] | [
"Sugar_Degrad_Dehydratases"
] | [
12193
] | 1 | [] | [] | [] | 0 | [
"5j83",
"5j84",
"5j85",
"5oyn",
"7m3k",
"8ej0",
"8epz",
"9evv"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine thaumarchaeote KM3_34_B07"
] | [
10565,
1422,
205,
1
] | 4 | [] | [] | 0 | true | Family | Sugar Degradation Dehydratases | Sugar Degradation Dehydratases | Sugar_Degrad_Dehydratases | 4 |
IPR052353 | 52,353 | Benzoxazolinone Detoxification Enzymes | Benzoxazolinone_Detox_Enz | Family | 13,504 | true | false | This family of proteins includes enzymes involved in the detoxification of plant-derived benzoxazolinones. These compounds are phytoanticipins produced by certain plants as a defense mechanism and can be toxic to other organisms. The proteins in this family participate in a multi-step degradation process that converts ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30212"
] | [
"Benzoxazolinone_Detox_Enz"
] | [
13504
] | 1 | [] | [] | [] | 0 | [
"1o65",
"1o67",
"5yhh",
"5yhi",
"6icm"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
14,
12414,
957,
119
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Family | Benzoxazolinone Detoxification Enzymes | Benzoxazolinone Detoxification Enzymes | Benzoxazolinone_Detox_Enz | 5 |
IPR052354 | 52,354 | Bacterial Cell Wall Dynamics Protein | Cell_Wall_Dynamics_Protein | Family | 10,275 | true | false | This family of proteins includes enzymes with roles in bacterial cell wall dynamics and integrity. Members are involved in processes such as peptidoglycan hydrolysis, which is crucial for cell wall lysis, cell viability, and various stages of bacterial life cycle including sporulation and germination. Some proteins in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34408"
] | [
"Cell_Wall_Dynamics_Protein"
] | [
10275
] | 1 | [] | [] | [] | 0 | [
"2kq8",
"2krs",
"2kt8",
"2kyb",
"4ok7",
"8p8e",
"8xcl",
"9eoi",
"9ms6",
"9ms7"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
9664,
80,
458,
73
] | 4 | [] | [] | 0 | true | Family | Bacterial Cell Wall Dynamics Protein | Bacterial Cell Wall Dynamics Protein | Cell_Wall_Dynamics_Protein | 5 |
IPR052355 | 52,355 | Centromere protein V-like | CENP-V-like | Family | 11,780 | true | false | This family of proteins is involved in the structural organization of chromosomes during cell division. Members are essential for the proper distribution of pericentromeric heterochromatin within interphase nuclei. They play a crucial role in the formation and organization of centromeres, which are key to chromosome al... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28620"
] | [
"CENP-V-like"
] | [
11780
] | 1 | [] | [] | [] | 0 | [
"3fac"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7228,
4492,
60
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
2,
1,
4,
1,
2,
3,
1,
12
] | 9 | true | Family | Centromere protein V-like | Centromere protein V-like | CENP-V-like | 5 |
IPR052356 | 52,356 | Thiol S-methyltransferase | Thiol_S-MT | Family | 11,706 | true | false | This family of proteins includes thiol S-methyltransferases that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to various thiol-containing substrates. These enzymes are involved in the methylation of small molecules such as hydrogen sulfide and dithiothreitol. Some family members are known to met... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45036"
] | [
"Thiol_S-MT"
] | [
11706
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"2.1.1.9",
"PWY-6736",
"PWY-6842",
"R-HSA-6798695"
] | [
"EC:2.1.1.9",
"METACYC:PWY-6736",
"METACYC:PWY-6842",
"REACTOME:R-HSA-6798695"
] | 4 | [
"8ys9"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
253,
6138,
5176,
139
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
3,
6,
14,
1,
2,
8,
6
] | 8 | true | Family | Thiol S-methyltransferase | Thiol S-methyltransferase | Thiol_S-MT | 2 |
IPR052357 | 52,357 | Orn/Lys/Arg decarboxylase class-I | Orn_Lys_Arg_decarboxylase-I | Family | 9,977 | true | false | The Orn/Lys/Arg decarboxylase class-I family is characterized by its members' enzymatic function in catalyzing the conversion of arginine to agmatine. This reaction is a key step in the biosynthesis of polyamines, which are critical for cell growth and differentiation. The family includes arginine decarboxylases that a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43277"
] | [
"Orn_Lys_Arg_decarboxylase-I"
] | [
9977
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.1.1.19",
"PWY-40",
"PWY-43",
"PWY-6834"
] | [
"EC:4.1.1.19",
"METACYC:PWY-40",
"METACYC:PWY-43",
"METACYC:PWY-6834"
] | 4 | [
"2x3l"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
20,
8789,
984,
184
] | 4 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
8
] | 2 | true | Family | Orn/Lys/Arg decarboxylase class-I | Orn/Lys/Arg decarboxylase class-I | Orn_Lys_Arg_decarboxylase-I | 9 |
IPR052358 | 52,358 | Aromatic Compound Degradation Hydrolases | Aro_Compnd_Degr_Hydrolases | Family | 9,268 | true | false | This family of proteins includes enzymes involved in the degradation of various aromatic compounds and sulfonated benzenes. Members of this family catalyze hydrolysis and isomerization reactions that are key steps in specific catabolic pathways. These reactions include the hydrolytical desulfonation of 4-sulfomuconolac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35563"
] | [
"Aro_Compnd_Degr_Hydrolases"
] | [
9268
] | 1 | [] | [] | [] | 0 | [
"2ffi",
"4d8l",
"4di8",
"4di9",
"4dia",
"4i6k",
"4mup"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Sym plasmid",
"unclassified sequences"
] | [
7404,
1788,
6,
1,
69
] | 5 | [] | [] | 0 | true | Family | Aromatic Compound Degradation Hydrolases | Aromatic Compound Degradation Hydrolases | Aro_Compnd_Degr_Hydrolases | 7 |
IPR052359 | 52,359 | Bacterial HTH-type regulators and antitoxins | HTH-type_reg/antitoxin | Family | 8,612 | true | false | This family of proteins includes transcriptional regulators and antitoxins involved in bacterial toxin-antitoxin (TA) systems. Members of this family function as antitoxins that neutralize the activity of cognate toxins, thereby preventing cell growth cessation and inhibition of cell proliferation. They can bind to DNA... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36511"
] | [
"HTH-type_reg/antitoxin"
] | [
8612
] | 1 | [] | [] | [] | 0 | [
"2kz8",
"3fmy",
"3gn5",
"3o9x",
"5j9i",
"5jaa",
"8a0w",
"8a0x"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcinales",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
8502,
9,
2,
4,
95
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Bacterial HTH-type regulators and antitoxins | Bacterial HTH-type regulators and antitoxins | HTH-type_reg/antitoxin | 8 |
IPR052361 | 52,361 | F-box domain-containing protein | F-box_domain | Family | 637 | true | false | This family of proteins includes members that are part of SCF (SKP1-cullin-F-box) E3 ubiquitin ligase complexes, which are involved in the ubiquitination and subsequent proteasomal degradation of target proteins. These proteins typically contain an F-box domain that is essential for interaction with SKP1 and other prot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31790"
] | [
"F-box_domain"
] | [
637
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
637
] | 1 | [] | [] | 0 | true | Family | F-box domain-containing protein | F-box domain-containing protein | F-box_domain | 5 |
IPR052362 | 52,362 | HTH-type GbsR-related transcriptional regulator | HTH-GbsR_regulator | Family | 9,551 | true | false | This family of proteins includes transcriptional regulators that are involved in the response to environmental conditions such as osmolarity. They regulate the expression of operons related to the transport and metabolism of compounds like choline and glycine betaine, which are important for cellular adjustment to osmo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38465"
] | [
"HTH-GbsR_regulator"
] | [
9551
] | 1 | [] | [] | [] | 0 | [
"1ku9",
"4nb5",
"5jbr"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
295,
9193,
4,
59
] | 4 | [] | [] | 0 | true | Family | HTH-type GbsR-related transcriptional regulator | HTH-type GbsR-related transcriptional regulator | HTH-GbsR_regulator | 7 |
IPR052363 | 52,363 | Lipopolysaccharide export system LptC | LPS_export_LptC | Family | 7,299 | true | false | This family of proteins is involved in the bacterial lipopolysaccharide (LPS) assembly pathway. Members of this family are essential for the translocation of LPS from the inner membrane to the outer membrane of Gram-negative bacteria. They act by facilitating the transfer of LPS to the periplasmic protein LptA and may ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37481"
] | [
"LPS_export_LptC"
] | [
7299
] | 1 | [] | [] | [] | 0 | [
"3my2",
"4b54",
"6mi7",
"6mit",
"6mjp",
"6s8n"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
7175,
8,
116
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Lipopolysaccharide export system LptC | Lipopolysaccharide export system LptC | LPS_export_LptC | 6 |
IPR052364 | 52,364 | Rubrerythrin | Rubrerythrin | Family | 5,080 | true | true | This family of proteins includes rubrerythrin from Porphyromonas gingivalis, Clostridium perfringens and related sequences from bacteria and archaea. Rubrerythrin is involved in cellular defense mechanisms against oxidative stress. Members of this family are known to catalyse the reduction of hydrogen peroxide, thereby... | [] | [] | [] | 0 | [
"NCBIFAM",
"PANTHER"
] | [
"NF045767",
"PTHR43865"
] | [
"RuberyRbr",
"Rubrerythrin-like"
] | [
3776,
5007
] | 2 | [] | [] | [] | 0 | [
"1b71",
"1dvb",
"1jyb",
"1lkm",
"1lko",
"1lkp",
"1qyb",
"1ryt",
"1s2z",
"1s30",
"9fj2"
] | 11 | [
"PUB00008767",
"PUB00098338",
"PUB00100840",
"PUB00154662",
"PUB00154663"
] | [
"8646540",
"19118342",
"11972784",
"8955396",
"2835096"
] | [
"The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains.",
"Pathway for H2O2 and O2 detoxification in Clostridium acetobutylicum.",
"Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis.",
"Rubrery... | [
1996,
2009,
2002,
1996,
1988
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
219,
4565,
65,
231
] | 4 | [] | [] | 0 | true | Family | Rubrerythrin | Rubrerythrin | Rubrerythrin | 3 |
IPR052365 | 52,365 | THEM4/THEM5 acyl-CoA thioesterase | THEM4/THEM5_acyl-CoA_thioest | Family | 7,762 | true | false | The THEM4/THEM5 thioesterase family is characterized by acyl-CoA thioesterase activity, specifically targeting medium and long-chain fatty acyl-CoA substrates, ranging from C14 to C18 in length. Members of the THEM4/THEM5 family are implicated in mitochondrial fatty acid metabolism, contributing to the regulation of en... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12418"
] | [
"THEM4/THEM5_acyl-CoA_thioest"
] | [
7762
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"3.1.2.2",
"PWY-1121",
"PWY-321",
"PWY-5972",
"PWY-5996",
"PWY-6733",
"PWY-7723",
"R-HSA-1257604",
"R-HSA-165158",
"R-HSA-199418",
"R-HSA-389357",
"R-HSA-5218920",
"R-HSA-77289",
"R-MMU-1257604",
"R-MMU-165158",
"R-MMU-199418",
"R-MMU-389357",
"R-MMU-5218920",
"R-MMU-77289",
"R... | [
"EC:3.1.2.2",
"METACYC:PWY-1121",
"METACYC:PWY-321",
"METACYC:PWY-5972",
"METACYC:PWY-5996",
"METACYC:PWY-6733",
"METACYC:PWY-7723",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-165158",
"REACTOME:R-HSA-199418",
"REACTOME:R-HSA-389357",
"REACTOME:R-HSA-5218920",
"REACTOME:R-HSA-77289",
"REACT... | 25 | [
"2ov9",
"4ae8",
"4gah"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7,
6507,
968,
280
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
4,
2,
4
] | 4 | true | Family | THEM4/THEM5 acyl-CoA thioesterase | THEM4/THEM5 acyl-CoA thioesterase | THEM4/THEM5_acyl-CoA_thioest | 3 |
IPR052366 | 52,366 | GTP Pyrophosphokinase | GTP_Pyrophosphokinase | Family | 8,941 | true | false | This family of proteins functions as (p)ppGpp synthases, enzymes that are integral to the stringent response in eubacteria. Members of this family catalyze the synthesis of ppGpp (guanosine 3'-diphosphate 5'-diphosphate), a molecule that coordinates cellular activities in response to nutritional changes. These proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47837"
] | [
"GTP_Pyrophosphokinase"
] | [
8941
] | 1 | [] | [] | [] | 0 | [
"2be3",
"3l9d",
"5dec",
"5ded",
"5f2v",
"6ewz",
"6ex0",
"6fgj",
"6fgk",
"6fgx",
"7ztb",
"9erv"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
9,
8864,
8,
19,
41
] | 5 | [] | [] | 0 | true | Family | GTP Pyrophosphokinase | GTP Pyrophosphokinase | GTP_Pyrophosphokinase | 7 |
IPR052367 | 52,367 | Thiosulfate Sulfurtransferase/Rhodanese-like Domain-Containing Protein | Thiosulfate_ST/Rhodanese-like | Family | 5,312 | true | false | This family of proteins is involved in sulfur metabolism, specifically in the transfer of sulfur from donor molecules. Members of this family are known to catalyze the transfer of sulfur to various acceptor compounds, including cyanide and thiol compounds, forming products such as sulfite and thiocyanate. Some proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45431"
] | [
"Thiosulfate_ST/Rhodanese-like"
] | [
5312
] | 1 | [] | [] | [] | 0 | [
"1tq1",
"2jtq",
"2jtr",
"2jts",
"8w14"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Myoviridae sp. ctTBm11",
"metagenomes"
] | [
4135,
1051,
20,
1,
105
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
1,
5,
6
] | 4 | true | Family | Thiosulfate Sulfurtransferase/Rhodanese-like Domain-Containing Protein | Thiosulfate Sulfurtransferase/Rhodanese-like Domain-Containing Protein | Thiosulfate_ST/Rhodanese-like | 6 |
IPR052368 | 52,368 | 2-oxoacid oxidoreductase subunit | 2-oxoacid_oxidoreductase | Family | 3,664 | true | false | This family of proteins includes subunits of enzymes involved in the oxidative decarboxylation of 2-oxo acids to form corresponding acyl-CoA derivatives, a key step in various metabolic pathways. The enzymes are multisubunit complexes, and the family members act as catalytic subunits that bind substrates and cofactors,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43088"
] | [
"2-oxoacid_oxidoreductase"
] | [
3664
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.7.3",
"PWY-5392",
"PWY-6969",
"PWY-7254"
] | [
"EC:1.2.7.3",
"METACYC:PWY-5392",
"METACYC:PWY-6969",
"METACYC:PWY-7254"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aduncisulcus paluster",
"Archaea",
"Bacteria",
"metagenomes"
] | [
1,
265,
3154,
244
] | 4 | [] | [] | 0 | true | Family | 2-oxoacid oxidoreductase subunit | 2-oxoacid oxidoreductase subunit | 2-oxoacid_oxidoreductase | 6 |
IPR052369 | 52,369 | Unsaturated Glycosaminoglycan Hydrolases | UG_Glycosaminoglycan_Hydrolase | Family | 8,571 | true | false | This family of proteins includes enzymes that catalyze the hydrolysis of unsaturated glycosaminoglycans, such as hyaluronate, chondroitin, and heparin disaccharides. They are involved in the degradation of extracellular matrix components, which is a crucial process in various biological contexts, including cell invasio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36845"
] | [
"UG_Glycosaminoglycan_Hydrolase"
] | [
8571
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.2.1.180",
"PWY-6572",
"PWY-7645"
] | [
"EC:3.2.1.180",
"METACYC:PWY-6572",
"METACYC:PWY-7645"
] | 3 | [
"1vd5",
"2ahf",
"2ahg",
"2d5j",
"2fuz",
"2fv0",
"2fv1",
"2zzr",
"3ani",
"3anj",
"3ank",
"3vxd",
"3wiw",
"3wux"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
36,
6776,
1680,
79
] | 4 | [] | [] | 0 | true | Family | Unsaturated Glycosaminoglycan Hydrolases | Unsaturated Glycosaminoglycan Hydrolases | UG_Glycosaminoglycan_Hydrolase | 8 |
IPR052371 | 52,371 | Bacterioferritin-associated ferredoxin | BFD-associated_ferredoxin | Family | 7,617 | true | false | This family of proteins is involved in iron storage and mobilization, potentially acting as a redox and/or regulatory component. Members of this family are thought to interact with bacterioferritin (BFR) and may play a role in the transfer of iron to and from BFR or other iron-containing complexes, thus participating i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37424"
] | [
"BFD-associated_ferredoxin"
] | [
7617
] | 1 | [] | [] | [] | 0 | [
"4e6k",
"6e6q",
"6e6r",
"6e6s"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"unclassified sequences"
] | [
7591,
2,
24
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterioferritin-associated ferredoxin | Bacterioferritin-associated ferredoxin | BFD-associated_ferredoxin | 3 |
IPR052372 | 52,372 | Inner Membrane Protein YpjD/HemX | YpjD/HemX | Family | 6,808 | true | false | The protein family includes inner membrane proteins named YpjD and a protein involved in HemL synthesis, HemX. The YpjD proteins are found in various strains of E. coli, suggesting a conserved role within these bacteria. HemX is required for the synthesis of HemL, indicating a function in heme biosynthesis. The unchara... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38034"
] | [
"YpjD/HemX"
] | [
6808
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Escherichia phage vB_EcoM-613R3",
"Eukaryota",
"unclassified sequences"
] | [
6697,
1,
7,
103
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Inner Membrane Protein YpjD/HemX | Inner Membrane Protein YpjD/HemX | YpjD/HemX | 9 |
IPR052373 | 52,373 | Gamma-glutamyl amide hydrolase | Gamma-glu_amide_hydrolase | Family | 7,943 | true | false | This family of proteins includes enzymes that are involved in the hydrolysis of gamma-glutamyl amide bonds in specific substrates. Members of this family play a role in the biosynthesis of ergothioneine, an important antioxidant that protects certain bacteria from oxidative stress. Ergothioneine acts as a redox buffer,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43187"
] | [
"Gamma-glu_amide_hydrolase"
] | [
7943
] | 1 | [
"EC",
"METACYC"
] | [
"3.5.1.118",
"PWY-7255"
] | [
"EC:3.5.1.118",
"METACYC:PWY-7255"
] | 2 | [
"3mdn",
"4zfj",
"4zfk",
"4zfl"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample",
"metagenomes"
] | [
6,
5587,
2318,
1,
31
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Gamma-glutamyl amide hydrolase | Gamma-glutamyl amide hydrolase | Gamma-glu_amide_hydrolase | 9 |
IPR052374 | 52,374 | SERAC1 | SERAC1 | Family | 9,376 | true | false | The SERAC1 family is implicated in essential biological processes involving lipid metabolism and intracellular trafficking. Members of this family are believed to play a crucial role in the remodeling of phosphatidylglycerol, a lipid component vital for mitochondrial functionality and cholesterol transport within cells... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48182"
] | [
"SERAC1"
] | [
9376
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
480,
8894,
2
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
8,
1,
7,
1,
4,
6
] | 6 | true | Family | SERAC1 | SERAC1 | SERAC1 | 8 |
IPR052376 | 52,376 | Oxidative Scavengers and Glycosyltransferases | Oxidative_Scav/Glycosyltrans | Family | 8,249 | true | false | This family of proteins includes members with diverse functions, ranging from scavenging oxidative molecules to glycosyltransferase activity involved in the biosynthesis of heparan-sulfate. Some members are responsible for protecting cells by neutralizing harmful oxidative products, while others play a crucial role in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39082"
] | [
"Oxidative_Scav/Glycosyltrans"
] | [
8249
] | 1 | [] | [] | [] | 0 | [
"3na7",
"4ilo",
"5y05",
"5y06"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bilateria",
"metagenomes"
] | [
6792,
1244,
213
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
3,
3
] | 4 | true | Family | Oxidative Scavengers and Glycosyltransferases | Oxidative Scavengers and Glycosyltransferases | Oxidative_Scav/Glycosyltrans | 5 |
IPR052377 | 52,377 | Mitochondrial enoyl-CoA hydratase domain-containing protein | Mitochondrial_ECH-domain | Family | 6,029 | true | false | This family of proteins is involved in the metabolic process of fatty acid biosynthesis, where they may contribute to the hydration of enoyl-CoA intermediates in the mitochondrial matrix. Additionally, these proteins are implicated in regulating insulin sensitivity, which is a critical aspect of glucose homeostasis in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43602"
] | [
"Mitochondrial_ECH-domain"
] | [
6029
] | 1 | [] | [] | [] | 0 | [
"2vx2",
"3l3s",
"3myb",
"9fia",
"9hqv"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
30,
3812,
2096,
91
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
4,
1,
4
] | 6 | true | Family | Mitochondrial enoyl-CoA hydratase domain-containing protein | Mitochondrial enoyl-CoA hydratase domain-containing protein | Mitochondrial_ECH-domain | 9 |
IPR052378 | 52,378 | Nitrous-oxide reductase regulator | NosR_regulator | Family | 4,458 | true | false | This family of proteins includes transcriptional activators that are involved in the regulation of nitrous-oxide reductase genes, such as NosZ. Members of this family are responsible for initiating the transcription of genes that encode for enzymes involved in the reduction of nitrous oxide, a significant step in the d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30224"
] | [
"NosR_regulator"
] | [
4458
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
71,
4169,
97,
121
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Nitrous-oxide reductase regulator | Nitrous-oxide reductase regulator | NosR_regulator | 5 |
IPR052382 | 52,382 | Mitochondrial ABHD10 acyl-protein thioesterase | ABHD10_acyl-thioesterase | Family | 4,889 | true | false | This family of proteins functions as acyl-protein thioesterases, hydrolyzing fatty acids from acylated protein residues. They play a role in regulating mitochondrial antioxidant capacity by modulating the S-depalmitoylation of peroxiredoxin-5, a key antioxidant enzyme. Additionally, they are involved in the metabolic p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16138"
] | [
"ABHD10_acyl-thioesterase"
] | [
4889
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.93",
"3.1.2.22",
"R-BTA-156588",
"R-HSA-156588",
"R-MMU-156588",
"R-RNO-156588"
] | [
"EC:3.1.1.93",
"EC:3.1.2.22",
"REACTOME:R-BTA-156588",
"REACTOME:R-HSA-156588",
"REACTOME:R-MMU-156588",
"REACTOME:R-RNO-156588"
] | 6 | [
"3llc",
"6ny9",
"8trf"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
40,
3236,
1555,
58
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
1,
5
] | 5 | true | Family | Mitochondrial ABHD10 acyl-protein thioesterase | Mitochondrial ABHD10 acyl-protein thioesterase | ABHD10_acyl-thioesterase | 3 |
IPR052383 | 52,383 | Anti-sigma-E factor RseA-like | Anti-sigma-E_RseA-like | Family | 5,322 | true | false | This family of proteins functions as anti-sigma factors for extracytoplasmic function (ECF) sigma factors, specifically sigma-E (RpoE). Members of this family regulate the activity of sigma-E by maintaining it in an inactive state until an extracytoplasmic signal induces a proteolytic cascade known as regulated intrame... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38104"
] | [
"Anti-sigma-E_RseA-like"
] | [
5322
] | 1 | [] | [] | [] | 0 | [
"1or7",
"3m4w",
"6in7",
"6in9",
"8z6g"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5261,
5,
56
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Anti-sigma-E factor RseA-like | Anti-sigma-E factor RseA-like | Anti-sigma-E_RseA-like | 9 |
IPR052384 | 52,384 | O-mannosyl-transferase TMTC | TMTC_O-mannosyltransferase | Family | 4,887 | true | false | This family of proteins includes O-mannosyl-transferases that are primarily involved in the post-translational modification of proteins by transferring mannosyl residues to the hydroxyl groups of serine or threonine residues. Members of this family have distinct roles, particularly in the modification of the cadherin s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44216"
] | [
"TMTC_O-mannosyltransferase"
] | [
4887
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.4.1.109",
"PWY-7921",
"PWY-7922",
"PWY-7979"
] | [
"EC:2.4.1.109",
"METACYC:PWY-7921",
"METACYC:PWY-7922",
"METACYC:PWY-7979"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
34,
1898,
2904,
51
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4,
4,
1,
4
] | 6 | true | Family | O-mannosyl-transferase TMTC | O-mannosyl-transferase TMTC | TMTC_O-mannosyltransferase | 9 |
IPR052385 | 52,385 | Obscurin and Obscurin-like Regulators | Obscurin/Obscurin-like_Reg | Family | 7,707 | true | false | This family of proteins includes structural components involved in myofibrillogenesis and the assembly of myosin into sarcomeric A bands in striated muscle. Members exhibit serine/threonine protein kinase activity, phosphorylating various substrates including N-cadherin and sodium/potassium-transporting ATPase subunits... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35971"
] | [
"Obscurin/Obscurin-like_Reg"
] | [
7707
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-8951664",
"R-HSA-8980692",
"R-HSA-9013406",
"R-MMU-193648",
"R-MMU-416482",
"R-MMU-8980692",
"R-MMU-9013406",
"R-RNO-8951664"
] | [
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013406",
"REACTOME:R-MMU-193648",
"REACTOME:R-MMU-416482",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013406",
"REACTOME:R-RNO-8951664"
] | 10 | [
"1pd6",
"1tit",
"1tiu",
"1waa",
"1x44",
"2cpc",
"2cr6",
"2dku",
"2dlt",
"2dm7",
"2e6p",
"2e6q",
"2e7b",
"2edf",
"2edh",
"2edk",
"2edl",
"2edq",
"2edr",
"2edt",
"2edw",
"2eny",
"2eo1",
"2gqh",
"2k1m",
"2lu7",
"2lvc",
"2mq0",
"2mq3",
"2mwc",
"2n56",
"2rq8"... | 59 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Pseudomonadati",
"bird metagenome"
] | [
7692,
14,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
106,
23,
17,
13
] | 4 | true | Family | Obscurin and Obscurin-like Regulators | Obscurin and Obscurin-like Regulators | Obscurin/Obscurin-like_Reg | 1 |
IPR052386 | 52,386 | G-protein-signaling modulator | GPSM | Family | 6,088 | true | false | The GPSM family includes guanine nucleotide dissociation inhibitors (GDIs) that regulate G-protein signaling independently of G protein-coupled receptors. Members of the GPSM family are involved in maintaining G(i/o) alpha subunits in their GDP-bound state, thus controlling heterotrimeric G-protein signaling. These pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45954"
] | [
"GPSM"
] | [
6088
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-418594",
"R-MMU-418594",
"R-RNO-418594"
] | [
"REACTOME:R-HSA-418594",
"REACTOME:R-MMU-418594",
"REACTOME:R-RNO-418594"
] | 3 | [
"3ro2",
"3ro3",
"3sf4",
"4a1s",
"4g2v",
"4jhr",
"4wnd",
"4wne",
"4wnf",
"4wng",
"5a6c",
"5a7d",
"6hc2",
"7ep7"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
53,
1040,
4969,
26
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
9,
3,
20,
8,
16
] | 6 | true | Family | G-protein-signaling modulator | G-protein-signaling modulator | GPSM | 6 |
IPR052387 | 52,387 | Fibrocystin | Fibrocystin | Family | 5,804 | true | true | This family of proteins is involved in promoting ciliogenesis within renal epithelial cells, contributing to the formation of kidney tubules and maintaining the lumen architecture [ , ]. They play a role in cellular symmetry, ensuring proper bipolar cell division by regulating centrosome duplication and mitotic spindle... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46769"
] | [
"Fibrocystin-related"
] | [
5804
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00069429",
"PUB00155066",
"PUB00155067",
"PUB00155068"
] | [
"20554582",
"18235088",
"20875407",
"30898581"
] | [
"Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity.",
"Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function.",
"Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelia... | [
2010,
2008,
2011,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Harvfovirus sp.",
"Stenosarchaea group",
"unclassified sequences"
] | [
1565,
4173,
1,
29,
36
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
8,
10
] | 4 | true | Family | Fibrocystin | Fibrocystin | Fibrocystin | 1 |
IPR052388 | 52,388 | Peroxisomal trans-2-enoyl-CoA reductase | Peroxisomal_t2-enoyl-CoA_red | Family | 4,410 | true | false | This family of proteins is involved in the metabolic process of fatty acid chain elongation within peroxisomes. Members of this family are enzymes that specifically catalyze the reduction of trans-2-enoyl-CoA substrates with chain lengths ranging from C6 to C16, with the highest activity observed for the C10 substrate.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24317"
] | [
"Peroxisomal_t2-enoyl-CoA_red"
] | [
4410
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.1.38",
"R-HSA-389599",
"R-HSA-9033241",
"R-MMU-389599",
"R-MMU-9033241",
"R-RNO-389599",
"R-RNO-9033241"
] | [
"EC:1.3.1.38",
"REACTOME:R-HSA-389599",
"REACTOME:R-HSA-9033241",
"REACTOME:R-MMU-389599",
"REACTOME:R-MMU-9033241",
"REACTOME:R-RNO-389599",
"REACTOME:R-RNO-9033241"
] | 7 | [
"1yxm",
"6lln"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
93,
2419,
1844,
54
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4,
7
] | 4 | true | Family | Peroxisomal trans-2-enoyl-CoA reductase | Peroxisomal trans-2-enoyl-CoA reductase | Peroxisomal_t2-enoyl-CoA_red | 5 |
IPR052389 | 52,389 | Secondary Metabolite Biosynthesis-Associated | Sec_Metab_Biosynth-Assoc | Family | 5,970 | true | false | This family of proteins includes enzymes involved in the biosynthesis of secondary metabolites such as glycolipid biosurfactants and reduced long-chain polyketides. Members of this family participate in complex gene clusters that mediate the production of specific bioactive compounds. These proteins are associated with... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38110"
] | [
"Sec_Metab_Biosynth-Assoc"
] | [
5970
] | 1 | [] | [] | [] | 0 | [
"3bbj",
"3rqb"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3874,
2026,
70
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Secondary Metabolite Biosynthesis-Associated | Secondary Metabolite Biosynthesis-Associated | Sec_Metab_Biosynth-Assoc | 8 |
IPR052390 | 52,390 | tRNA Nucleotidyltransferase/Poly(A) Polymerase | tRNA_nt/polyA_polymerase | Family | 1,995 | true | false | The tRNA nucleotidyltransferase/poly(A) polymerase family is involved in the synthesis of the tRNA CCA terminus, which is crucial for proper tRNA function and protein synthesis. Members of this family add the terminal adenosine residue to tRNA, and in some cases, can also add cytidine residues. The enzymes adopt a seah... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47788"
] | [
"tRNA_nt/polyA_polymerase"
] | [
1995
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.-",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179"
] | [
"EC:2.7.7.-",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-7735",
"METACYC:PWY-7737",
"METACYC:PWY-7769",
"METACYC:PWY-7... | 18 | [
"1vfg",
"3h37",
"3h38",
"3h39",
"3h3a",
"4wby",
"4wbz",
"4wc0",
"4wc1",
"4wc2",
"4wc3",
"4wc4",
"4wc5",
"4wc6",
"4wc7",
"4x0a",
"4x0b",
"5hc9"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5,
1690,
121,
179
] | 4 | [] | [] | 0 | true | Family | tRNA Nucleotidyltransferase/Poly(A) Polymerase | tRNA Nucleotidyltransferase/Poly(A) Polymerase | tRNA_nt/polyA_polymerase | 6 |
IPR052392 | 52,392 | Kelch repeat and BTB domain-containing protein | Kelch-BTB_domain-containing | Family | 4,788 | true | false | This family of proteins serves as substrate-specific adapters for BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes, which are involved in the ubiquitination and degradation of target proteins. Members of this family are characterized by the presence of kelch repeats and a BTB domain, which is responsible for mediating... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46375"
] | [
"Kelch-BTB_domain-containing"
] | [
4788
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168"
] | 4 | [
"1u6d",
"1x2j",
"1x2r",
"1zgk",
"2flu",
"2xn4",
"3ii7",
"4asc",
"4chb",
"5cgj",
"5fnq",
"5fnr",
"5fns",
"5fnt",
"5fnu",
"5fzj",
"5fzn",
"5wfl",
"5wfv",
"5wg1",
"5whl",
"5who",
"5wiy",
"6qmc",
"6qmd",
"6qme",
"6qmj",
"6qmk",
"6zew",
"6zex",
"6zey",
"6zez"... | 85 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrososphaerota",
"Viruses",
"metagenomes"
] | [
522,
4195,
5,
52,
14
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
9,
8,
10,
3
] | 5 | true | Family | Kelch repeat and BTB domain-containing protein | Kelch repeat and BTB domain-containing protein | Kelch-BTB_domain-containing | 6 |
IPR052393 | 52,393 | Cadmium-induced response protein | Cadmium-induced_rsp | Family | 3,838 | true | false | This family of proteins includes cadmium-induced proteins that are suggested to be involved in the cellular response to cadmium exposure. The proteins in this family are indicated to have similarity to bacterial proteins, which may imply a role in metal ion binding or detoxification processes. However, the specific fun... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR41294"
] | [
"Cadmium-induced_rsp"
] | [
3838
] | 1 | [] | [] | [] | 0 | [
"5c4p",
"5c68",
"5c6x",
"5cb9",
"5d4f",
"5dfg",
"5drh",
"5hcw",
"5v0f",
"6xa0",
"6xck"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Kipferlia bialata",
"metagenomes"
] | [
3773,
1,
64
] | 3 | [] | [] | 0 | true | Family | Cadmium-induced response protein | Cadmium-induced response protein | Cadmium-induced_rsp | 1 |
IPR052394 | 52,394 | Leucine-rich repeat-containing protein | LRR-containing | Family | 9,982 | true | false | This family of proteins contains leucine-rich repeat (LRR) motifs, which are typically involved in protein-protein interactions. The LRR motifs consist of 20-30 amino acids and are rich in leucine residues. Proteins with LRRs are known to participate in a variety of cellular processes including signal transduction, cel... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24114"
] | [
"LRR-containing"
] | [
9982
] | 1 | [] | [] | [] | 0 | [
"9e5c",
"9fqr"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
170,
9803,
6,
3
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Zea mays"
] | [
1,
3,
3,
7,
4,
1,
8,
3
] | 8 | true | Family | Leucine-rich repeat-containing protein | Leucine-rich repeat-containing protein | LRR-containing | 4 |
IPR052395 | 52,395 | Electron Transfer Ferredoxin | ET_Ferredoxin | Family | 4,139 | true | false | This family of proteins includes iron-sulfur proteins that are involved in electron transfer across a range of metabolic processes. One member of this family is known to participate as a phosphodonor to cytochrome P450 BioI, indicating a role in biosynthetic pathways. The electron transfer function is fundamental to va... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39163"
] | [
"ET_Ferredoxin"
] | [
4139
] | 1 | [] | [] | [] | 0 | [
"1dax",
"1dfd",
"1fxr",
"1iqz",
"1ir0",
"1wtf",
"7m1n",
"7m1o",
"7yl8"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
16,
4074,
3,
4,
42
] | 5 | [] | [] | 0 | true | Family | Electron Transfer Ferredoxin | Electron Transfer Ferredoxin | ET_Ferredoxin | 6 |
IPR052396 | 52,396 | Meiotic Drive Suppressor Kinase | Meiotic_Drive_Suppr_Kinase | Family | 4,800 | true | false | This family of proteins is involved in the regulation of meiotic drive, a process that biases the transmission of alleles to progeny. Members of this family function as a poison/antidote system, where they may act as a DNA nuclease that leads to the killing of spores that do not inherit the allele, while also possessin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37171"
] | [
"Meiotic_Drive_Suppr_Kinase"
] | [
4800
] | 1 | [] | [] | [] | 0 | [
"7vnx"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
174,
1088,
3530,
5,
3
] | 5 | [] | [] | 0 | true | Family | Meiotic Drive Suppressor Kinase | Meiotic Drive Suppressor Kinase | Meiotic_Drive_Suppr_Kinase | 2 |
IPR052397 | 52,397 | NADPH:quinone oxidoreductase MdaB | NADPH-QR_MdaB | Family | 4,344 | true | false | This family of proteins includes NADPH-specific quinone reductases that are most active with quinone derivatives and ferricyanide as electron acceptors. They can utilize menadione, 1,4-naphthoquinone, and 1,4-benzoquinone as substrates. Members of this family may operate in conjunction with other proteins to form a qui... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46305"
] | [
"NADPH-QR_MdaB"
] | [
4344
] | 1 | [
"EC"
] | [
"1.6.5.10"
] | [
"EC:1.6.5.10"
] | 1 | [
"2amj",
"2b3d",
"3rpe",
"4s24"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nitrosopumilus maritimus (strain SCM1)",
"metagenomes",
"unclassified Caudoviricetes"
] | [
4285,
45,
1,
11,
2
] | 5 | [
"Escherichia coli (strain K12)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | NADPH:quinone oxidoreductase MdaB | NADPH:quinone oxidoreductase MdaB | NADPH-QR_MdaB | 8 |
IPR052398 | 52,398 | Ubiquitin carboxyl-terminal hydrolase 53/54 | Ubiquitin_hydrolase_53/54 | Family | 6,570 | true | true | This family includes ubiquitin carboxyl-terminal hydrolases 53 and 54 that, despite their classification in the peptidase C19 family, do not exhibit peptidase activity. Instead, certain members of this family are associated with tight junctions and are implicated in the survival of auditory hair cells and hearing. They... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22975"
] | [
"Inactive_ubiquitin_hydrolase"
] | [
6570
] | 1 | [
"EC"
] | [
"3.4.19.12"
] | [
"EC:3.4.19.12"
] | 1 | [
"8c61"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6570
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
139,
35,
4,
22,
7,
27,
7,
53
] | 8 | true | Family | Ubiquitin carboxyl-terminal hydrolase 53/54 | Ubiquitin carboxyl-terminal hydrolase 53/54 | Ubiquitin_hydrolase_53/54 | 5 |
IPR052399 | 52,399 | Phage Baseplate Assembly Protein | Phage_Baseplate_Assmbl_Protein | Family | 6,189 | true | false | This family of proteins includes components typically associated with bacteriophage baseplates, suggesting a role in phage assembly or function. Members are likely involved in the structural formation of the phage tail, which is critical for the phage's ability to infect host bacteria. The presence of these proteins in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37829"
] | [
"Phage_Baseplate_Assmbl_Protein"
] | [
6189
] | 1 | [] | [] | [] | 0 | [
"8v3w",
"8v41",
"8v43",
"9g8s",
"9gb2",
"9ki1"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
43,
5791,
17,
297,
41
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phage Baseplate Assembly Protein | Phage Baseplate Assembly Protein | Phage_Baseplate_Assmbl_Protein | 2 |
IPR052402 | 52,402 | ADCK protein kinase | ADCK_kinase | Family | 5,686 | true | false | The ADCK protein kinase family is part of the larger protein kinase superfamily. Members of the ADCK family are characterized by the presence of an aarF domain and are typically associated with mitochondrial functions. Although the precise biochemical activities of these kinases are not fully understood, they are belie... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45890"
] | [
"ADCK_kinase"
] | [
5686
] | 1 | [
"EC"
] | [
"2.7.11.-"
] | [
"EC:2.7.11.-"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
256,
5377,
11,
42
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
10,
2,
1,
5,
6,
1,
8,
3,
1,
1,
12
] | 11 | true | Family | ADCK protein kinase | ADCK protein kinase | ADCK_kinase | 8 |
IPR052403 | 52,403 | LINC complex-associated protein | LINC-complex_assoc | Family | 5,097 | true | false | This family of proteins is involved in the LINC complex, which connects the nuclear lamina to the cytoskeleton, facilitating the transmission of mechanical forces across the nuclear envelope and playing a role in nuclear movement and positioning. Members of this family are likely to serve as anchoring proteins, tetheri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47535"
] | [
"LINC-complex_assoc"
] | [
5097
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
4,
5093
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
14,
14,
7,
11
] | 5 | true | Family | LINC complex-associated protein | LINC complex-associated protein | LINC-complex_assoc | 3 |
IPR052404 | 52,404 | SPP1-like small terminase | SPP1-like_terminase | Family | 3,564 | true | false | The SPP1-like small terminase family is involved in the packaging of viral DNA into the procapsid of bacteriophages. Members of this family recognize specific DNA packaging sequences and regulate the ATPase activity of the terminase large subunit. The small terminase subunit, in conjunction with the large subunit, form... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR41328"
] | [
"SPP1-like_terminase"
] | [
3564
] | 1 | [] | [] | [] | 0 | [
"2cmp",
"3zqp",
"3zqq",
"4zc3"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanolapillus millepedarum",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
3124,
1,
2,
371,
66
] | 5 | [] | [] | 0 | true | Family | SPP1-like small terminase | SPP1-like small terminase | SPP1-like_terminase | 9 |
IPR052405 | 52,405 | Mitochondrial Translation Release Factor | Mito_Transl_Release_Factor | Family | 3,720 | true | false | This family of proteins is involved in the quality control of mitochondrial translation. Members of this family function as part of a mitoribosome-associated pathway that addresses interruptions during elongation. They form heterodimers with MTRES1 to facilitate the ejection of incomplete nascent chains and peptidyl tr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46203"
] | [
"Mito_Transl_Release_Factor"
] | [
3720
] | 1 | [
"REACTOME"
] | [
"R-HSA-9937383"
] | [
"REACTOME:R-HSA-9937383"
] | 1 | [
"2rsm",
"7a5h"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
423,
3274,
23
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
3,
1,
3,
1,
1,
2,
1,
1
] | 9 | true | Family | Mitochondrial Translation Release Factor | Mitochondrial Translation Release Factor | Mito_Transl_Release_Factor | 7 |
IPR052406 | 52,406 | Chromatin Remodeling Complex Component | Chromatin_Remodeling_Comp | Family | 4,960 | true | false | This family of proteins is involved in chromatin remodeling, which is a critical process in the regulation of gene expression. Members of this family participate in altering DNA-nucleosome topology, thereby affecting transcriptional activation and repression of specific genes. They are components of various chromatin r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22970"
] | [
"Chromatin_Remodeling_Comp"
] | [
4960
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214858",
"R-HSA-8939243",
"R-HSA-9933939"
] | [
"REACTOME:R-HSA-3214858",
"REACTOME:R-HSA-8939243",
"REACTOME:R-HSA-9933939"
] | 3 | [
"6k15",
"6kw3",
"6kw4",
"6kw5",
"6tda",
"6v8o",
"6v92",
"7vdv",
"7y8r"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Niabella soli DSM 19437"
] | [
4959,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
2,
3,
9,
6,
1,
5,
1,
1
] | 9 | true | Family | Chromatin Remodeling Complex Component | Chromatin Remodeling Complex Component | Chromatin_Remodeling_Comp | 9 |
IPR052407 | 52,407 | BTB/POZ domain-containing protein 9 | BTB_POZ_domain_cont_9 | Family | 5,188 | true | false | This family of proteins includes BTB/POZ domain-containing proteins that are implicated in the regulation of sleep and motor activity. They are believed to play a role in maintaining homeostasis in these processes, potentially by influencing dopamine biosynthesis, which is a critical neurotransmitter involved in the co... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46306"
] | [
"BTB_POZ_domain_cont_9"
] | [
5188
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
46,
5141,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
5,
14,
5
] | 6 | true | Family | BTB/POZ domain-containing protein 9 | BTB/POZ domain-containing protein 9 | BTB_POZ_domain_cont_9 | 1 |
IPR052408 | 52,408 | Exonuclease MUT-7-like | Exonuclease_MUT-7-like | Family | 6,078 | true | false | This family of proteins includes exonucleases with a role in RNA interference and miRNA processing. Members are involved in the repression of transposon activity, possibly through the degradation of transposon-specific RNA. They are also implicated in the 3'-5' exoribonuclease activity required for the maturation of mi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47765"
] | [
"Exonuclease_MUT-7-like"
] | [
6078
] | 1 | [] | [] | [] | 0 | [
"7jw2",
"7jw3",
"7jw6",
"8q66"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
5099,
946,
33
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
3,
3,
2,
1,
7,
21
] | 7 | true | Family | Exonuclease MUT-7-like | Exonuclease MUT-7-like | Exonuclease_MUT-7-like | 1 |
IPR052410 | 52,410 | Dynein regulatory complex subunit 5 | DRC5 | Family | 3,106 | true | false | This family of proteins is involved in the regulation of ciliary and flagellar motility, specifically through the nexin-dynein regulatory complex (N-DRC). Members of this family are essential for maintaining the alignment and integrity of the distal axoneme and for regulating microtubule sliding in motile axonemes. The... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24107"
] | [
"DRC5"
] | [
3106
] | 1 | [] | [] | [] | 0 | [
"8glv",
"8j07",
"9e5c",
"9fqr"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Indivirus ILV1",
"marine sediment metagenome"
] | [
41,
3063,
1,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
5,
1,
5,
1,
1,
3,
1
] | 7 | true | Family | Dynein regulatory complex subunit 5 | Dynein regulatory complex subunit 5 | DRC5 | 5 |
IPR052411 | 52,411 | c/mor Transcriptional Regulatory Protein | c-mor_Regulatory_Protein | Family | 3,524 | true | false | This family of proteins includes transcriptional regulators that are involved in the regulation of gene expression in response to various stimuli such as DNA damage and the progression of viral infection. Members of this family typically contain a helix-turn-helix (HTH) motif for DNA-binding and may also have domains f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37812"
] | [
"c-mor_Regulatory_Protein"
] | [
3524
] | 1 | [] | [] | [] | 0 | [
"1rr7"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
3448,
38,
6,
32
] | 4 | [] | [] | 0 | true | Family | c/mor Transcriptional Regulatory Protein | c/mor Transcriptional Regulatory Protein | c-mor_Regulatory_Protein | 8 |
IPR052413 | 52,413 | SUR7 domain-containing protein | SUR7_domain | Family | 4,477 | true | false | This family of proteins appears to be involved in cellular responses to environmental stress, particularly nitrogen stress, and may play a role in the regulation of amino acid biosynthesis. Members of this family are also implicated in processes such as filamentous growth, cell growth, and cell-cell adhesion. Some prot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28019"
] | [
"SUR7_domain"
] | [
4477
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4477
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
4,
1
] | 3 | true | Family | SUR7 domain-containing protein | SUR7 domain-containing protein | SUR7_domain | 3 |
IPR052414 | 52,414 | U3 small nucleolar RNA-associated WD repeat-containing protein | U3_snoRNA-assoc_WDR | Family | 4,579 | true | false | This family of proteins is involved in ribosome biogenesis, particularly in the processing and transcription of pre-18S ribosomal RNA. Members of this family are part of the small subunit (SSU) processome, which is the first precursor of the small eukaryotic ribosomal subunit. They play a role in coordinating the assem... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44267"
] | [
"U3_snoRNA-assoc_WDR"
] | [
4579
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 5 | [
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 45 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4579
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
2,
4,
3,
1,
2,
5,
1,
2,
5
] | 12 | true | Family | U3 small nucleolar RNA-associated WD repeat-containing protein | U3 small nucleolar RNA-associated WD repeat-containing protein | U3_snoRNA-assoc_WDR | 5 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.