interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052415 | 52,415 | Diphthine methyltransferase | Diphthine_MTase | Family | 4,528 | true | false | This family of proteins catalyzes the demethylation of diphthine methyl ester to form diphthine, an essential step in the biosynthesis of diphthamide, a unique post-translational modification of histidine found in translation elongation factor 2. Diphthamide modification is critical for the function of elongation facto... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46042"
] | [
"Diphthine_MTase"
] | [
4528
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"3.1.1.97",
"PWY-7546",
"R-HSA-5358493"
] | [
"EC:3.1.1.97",
"METACYC:PWY-7546",
"REACTOME:R-HSA-5358493"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4528
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
2,
12,
16,
2,
5,
1,
3,
2,
1,
1,
2
] | 12 | true | Family | Diphthine methyltransferase | Diphthine methyltransferase | Diphthine_MTase | 3 |
IPR052416 | 52,416 | General transcription factor 3C component | GTF3C_component | Family | 4,531 | true | false | This family of proteins is involved in the transcription process mediated by RNA polymerase III. Members of this family are components of the transcription factor complex TFIIIC, which is essential for the assembly of the transcription initiation complex on tRNA genes and the transcription of 5S rRNA and other stable R... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15052"
] | [
"GTF3C_component"
] | [
4531
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-749476",
"R-HSA-76061",
"R-HSA-76066",
"R-MMU-76061",
"R-MMU-76066",
"R-SCE-76066",
"R-SPO-76061",
"R-SPO-76066"
] | [
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76061",
"REACTOME:R-HSA-76066",
"REACTOME:R-MMU-76061",
"REACTOME:R-MMU-76066",
"REACTOME:R-SCE-76066",
"REACTOME:R-SPO-76061",
"REACTOME:R-SPO-76066"
] | 8 | [
"2j04",
"8cli",
"8clj",
"8cll",
"8ffz",
"9gc3"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Staphylococcus capitis"
] | [
4530,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
4,
4,
6,
3,
1,
11,
4,
1,
1,
11
] | 11 | true | Family | General transcription factor 3C component | General transcription factor 3C component | GTF3C_component | 7 |
IPR052417 | 52,417 | Dachshund domain-containing protein | Dachshund_domain | Family | 4,461 | true | false | This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12577"
] | [
"Dachshund_domain"
] | [
4461
] | 1 | [] | [] | [] | 0 | [
"1l8r"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4461
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
41,
12,
11,
7,
10
] | 6 | true | Family | Dachshund domain-containing protein | Dachshund domain-containing protein | Dachshund_domain | 7 |
IPR052418 | 52,418 | Apolipoprotein B | Apolipoprotein_B | Family | 4,048 | true | false | The Apolipoprotein B family comprises proteins that are key constituents of lipoprotein particles such as chylomicrons, LDL, and VLDL. Members of this family, including Apolipoprotein B-100, play a crucial role in lipid transport and metabolism. They are recognized by the apoB/E receptor, which facilitates the cellular... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13769"
] | [
"Apolipoprotein_B"
] | [
4048
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-202733",
"R-HSA-3000471",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-432142",
"R-HSA-5686938",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8866423",
"R-HSA-8957275",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964026",
"R-HSA-8964038",
"R-HSA-8964041"... | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3000497",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-5686938",
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-8866423",
"REACTOME:R... | 56 | [
"9bd1",
"9bd8",
"9bde",
"9bdt",
"9coo",
"9e9r",
"9ea7",
"9eag"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
4045
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
19,
5,
11
] | 4 | true | Family | Apolipoprotein B | Apolipoprotein B | Apolipoprotein_B | 5 |
IPR052419 | 52,419 | 5'(3')-deoxyribonucleotidase-like | 5_3-deoxyribonucleotidase-like | Family | 2,905 | true | false | This family of proteins is involved in the hydrolysis of nucleotide monophosphates, which is a process of removing a phosphate group from the molecule. Members of this family are known to act on various nucleotide monophosphates and sugar phosphates, suggesting a role in nucleotide metabolism and possibly in the regula... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35134"
] | [
"5_3-deoxyribonucleotidase-like"
] | [
2905
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.3.-",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119",
"PWY-7321",
"PWY-7531",
"PWY-7771... | [
"EC:3.1.3.-",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACYC:PWY-6686",
"METACYC:PWY-6720",
"METACYC:PWY-6... | 36 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
52,
1561,
1230,
18,
44
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
13
] | 3 | true | Family | 5'(3')-deoxyribonucleotidase-like | 5'(3')-deoxyribonucleotidase-like | 5_3-deoxyribonucleotidase-like | 3 |
IPR052421 | 52,421 | Plant Cell Wall Enzyme Inhibitor | PCW_Enzyme_Inhibitor | Family | 5,659 | true | false | This family of proteins includes inhibitors that target specific enzymes involved in the modification of cell wall components. Members of this family are known to inhibit fructosidases and pectin methylesterases, which are enzymes that play roles in plant development and metabolism. These inhibitors are involved in var... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36710"
] | [
"PCW_Enzyme_Inhibitor"
] | [
5659
] | 1 | [] | [] | [] | 0 | [
"1x8z",
"1x90",
"1x91",
"1xg2"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
5659
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
110,
2,
1
] | 3 | true | Family | Plant Cell Wall Enzyme Inhibitor | Plant Cell Wall Enzyme Inhibitor | PCW_Enzyme_Inhibitor | 2 |
IPR052422 | 52,422 | Auxin Signal Transduction Ser/Thr Kinase | Auxin_Ser/Thr_Kinase | Family | 5,186 | true | false | This family of proteins is involved in auxin signal transduction, which is a key process in plant growth and development. Members of this family function as receptor-like kinases and are implicated in the regulation of cell expansion and proliferation. Some proteins within this family form complexes that activate ROP s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47986"
] | [
"Auxin_Ser/Thr_Kinase"
] | [
5186
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [
"4hq1",
"7brc"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
5183
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
31,
23,
26
] | 3 | true | Family | Auxin Signal Transduction Ser/Thr Kinase | Auxin Signal Transduction Ser/Thr Kinase | Auxin_Ser/Thr_Kinase | 6 |
IPR052423 | 52,423 | Erythrocyte Membrane Invagination Regulator | EMIR | Family | 4,128 | true | false | This family of proteins is involved in the structural modification of the erythrocyte membrane. Members of this family are implicated in the alteration of intermolecular interactions within the cytoplasmic domain of band 3, a process that is critical for the formation of the parasitophorous vacuole. This vacuole is ess... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44094"
] | [
"EMIR"
] | [
4128
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
86,
4038,
4
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
15,
44
] | 3 | true | Family | Erythrocyte Membrane Invagination Regulator | Erythrocyte Membrane Invagination Regulator | EMIR | 2 |
IPR052424 | 52,424 | Kielin/Chordin-like & BMP-binding Regulator | Kielin_Chordin-BMP_Reg | Family | 4,607 | true | false | The Kielin/chordin-like and BMP-binding endothelial regulator protein family is involved in the regulation of bone morphogenetic protein (BMP) signaling pathways. Members of the family enhance BMP signaling in a paracrine manner and are known to inhibit activin-A and TGFB1-mediated signaling pathways. Additionally, the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46698"
] | [
"Kielin_Chordin-BMP_Reg"
] | [
4607
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Polyangiaceae"
] | [
4598,
9
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
8,
19,
13,
7
] | 5 | true | Family | Kielin/Chordin-like & BMP-binding Regulator | Kielin/Chordin-like & BMP-binding Regulator | Kielin_Chordin-BMP_Reg | 5 |
IPR052425 | 52,425 | Uncharacterized MFS-type Transporter | Uncharacterized_MFS-type | Family | 2,239 | true | false | This family of proteins includes uncharacterized members that are predicted to be involved in transport across membranes, as some members are similar to the major facilitator superfamily (MFS). MFS transporters are integral membrane proteins responsible for the movement of a wide variety of substrates across cellular m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42688"
] | [
"Uncharacterized_MFS-type"
] | [
2239
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Myoviridae sp. ctLjW1",
"leotiomyceta",
"metagenomes"
] | [
160,
2052,
1,
3,
23
] | 5 | [] | [] | 0 | true | Family | Uncharacterized MFS-type Transporter | Uncharacterized MFS-type Transporter | Uncharacterized_MFS-type | 6 |
IPR052426 | 52,426 | Plant developmental regulator | Plant_dev_regulator | Family | 4,920 | true | false | This family of proteins includes probable transcriptional regulators involved in various developmental processes in plants. Members of this family are implicated in the regulation of cell proliferation, floral organ development, and maintenance of meristem determinacy. They may act by repressing genes associated with c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45801"
] | [
"Plant_dev_regulator"
] | [
4920
] | 1 | [] | [] | [] | 0 | [
"1njq",
"2l1o"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
4920
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
35,
22,
30
] | 3 | true | Family | Plant developmental regulator | Plant developmental regulator | Plant_dev_regulator | 6 |
IPR052427 | 52,427 | Glycosyltransferase family GT2 and GT47 | Glycosyltrans_GT2/GT47 | Family | 3,638 | true | false | The GT2 glycosyltransferase family is involved in various biological processes across different organisms. In fungi, members of this family maintain the cell wall's outer surface by synthesizing an unknown extracellular or cell wall polysaccharide, essential for plant-fungal interactions and hyphal growth on solid matr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47844"
] | [
"Glycosyltrans_GT2/GT47"
] | [
3638
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 203 | [
"1omx",
"1omz",
"1on6",
"1on8"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halogeometricum luteum",
"ecological metagenomes",
"unclassified Klosneuvirinae"
] | [
17,
3615,
1,
2,
3
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
10,
6,
2,
3
] | 5 | true | Family | Glycosyltransferase family GT2 and GT47 | Glycosyltransferase family GT2 and GT47 | Glycosyltrans_GT2/GT47 | 8 |
IPR052428 | 52,428 | Autophagy and Host Defense Regulator | Autophagy_HostDef_Reg | Family | 3,668 | true | false | The protein family is involved in the regulation of autophagy and host defense mechanisms. Members promote autophagosome maturation by facilitating the production of PtdIns(3)P and antagonizing negative regulators of the PI3K/PI3KC3 complex. They bind various phosphoinositides and recruit complexes to autophagosomes, i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45971"
] | [
"Autophagy_HostDef_Reg"
] | [
3668
] | 1 | [] | [] | [] | 0 | [
"6wcw"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3668
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
7,
3,
16,
6,
3,
9,
8
] | 8 | true | Family | Autophagy and Host Defense Regulator | Autophagy and Host Defense Regulator | Autophagy_HostDef_Reg | 7 |
IPR052429 | 52,429 | BAH domain-containing protein | BAH_domain_protein | Family | 3,834 | true | false | This family of proteins includes members with a BAH domain, which is implicated in chromosomal localization and gene regulation. One characterized function within this family is the determination of tissue-specific identity, particularly in the context of developmental processes. For example, a member of this family in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12505"
] | [
"BAH_domain_protein"
] | [
3834
] | 1 | [] | [] | [] | 0 | [
"6vil",
"8ds8",
"8ye8"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
3831,
3
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
2,
16,
7,
11
] | 5 | true | Family | BAH domain-containing protein | BAH domain-containing protein | BAH_domain_protein | 2 |
IPR052430 | 52,430 | Intracellular Vesicle Transport-Associated | IVT-Associated | Family | 3,749 | true | false | This family of proteins appears to be involved in intracellular vesicle transport, a critical process for the trafficking of molecules within cells. The proteins may play a role in the movement of vesicles between different cellular compartments, ensuring the proper distribution of proteins, lipids, and other substance... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47804"
] | [
""
] | [
3749
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"plant metagenome"
] | [
338,
3408,
3
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | Intracellular Vesicle Transport-Associated | Intracellular Vesicle Transport-Associated | IVT-Associated | 3 |
IPR052431 | 52,431 | SKI2 subfamily ATP-dependent RNA helicases | SKI2_subfamily_helicases | Family | 3,345 | true | false | The helicase family, specifically the SKI2 subfamily, is characterized by proteins that exhibit nucleic acid unwinding activity, which is essential for various aspects of RNA and DNA metabolism. Members of this family are involved in processes such as RNA surveillance, splicing, and ribosome biogenesis. One member, DDX... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44533"
] | [
"SKI2_subfamily_helicases"
] | [
3345
] | 1 | [
"EC",
"METACYC"
] | [
"3.6.4.-",
"PWY-7250"
] | [
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 2 | [
"7ase",
"7ask"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae",
"Vibrio lentus",
"metagenomes"
] | [
3320,
2,
1,
22
] | 4 | [
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
21,
7,
2,
7,
1
] | 6 | true | Family | SKI2 subfamily ATP-dependent RNA helicases | SKI2 subfamily ATP-dependent RNA helicases | SKI2_subfamily_helicases | 7 |
IPR052432 | 52,432 | Phosphatidylinositol transfer protein/CRAL-TRIO domain | PITP/CRAL-TRIO | Family | 3,560 | true | false | The protein family is characterized by its involvement in lipid transfer and membrane trafficking. Members of the family are non-classical phosphatidylinositol transfer proteins (PITPs) that exhibit phosphatidylinositol-binding/transfer activity. They play a role in activating phospholipase D1, modulating ArfGAP functi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46590"
] | [
"PITP/CRAL-TRIO"
] | [
3560
] | 1 | [] | [] | [] | 0 | [
"7wvt",
"7wwd",
"7wwe",
"7wwg"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3560
] | 1 | [
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1,
3
] | 4 | true | Family | Phosphatidylinositol transfer protein/CRAL-TRIO domain | Phosphatidylinositol transfer protein/CRAL-TRIO domain | PITP/CRAL-TRIO | 2 |
IPR052433 | 52,433 | Xaa-Pro dipeptidase-like | X-Pro_dipept-like | Family | 30,270 | true | true | Xaa-Pro dipeptidase specialises in the hydrolysis of dipeptides where the C-terminal residue is either proline (Xaa-Pro) or hydroxyproline [ , ]. These enzyme preferentially cleave Gly-Pro dipeptides but are also capable of processing other dipeptides with a prolyl residue, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro, a... | [] | [] | [] | 0 | [
"PANTHER",
"PANTHER"
] | [
"PTHR43226",
"PTHR48480"
] | [
"Peptidase_M24B",
""
] | [
26471,
3799
] | 2 | [] | [] | [] | 0 | [
"1a16",
"1jaw",
"1m35",
"1n51",
"1w2m",
"1w7v",
"1wbq",
"1wl6",
"1wl9",
"1wlr",
"2bh3",
"2bha",
"2bhb",
"2bhc",
"2bhd",
"2bn7",
"2bws",
"2bwt",
"2bwu",
"2bwv",
"2bww",
"2bwx",
"2bwy",
"2iw2",
"2okn",
"2v3x",
"2v3y",
"2v3z",
"3ig4",
"3l24",
"3l7g",
"3rva"... | 64 | [
"PUB00002536",
"PUB00155274",
"PUB00155275"
] | [
"2925654",
"17081196",
"35165443"
] | [
"Primary structure and gene localization of human prolidase.",
"Human recombinant prolidase from eukaryotic and prokaryotic sources. Expression, purification, characterization and long-term stability studies.",
"M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome."
] | [
1989,
2006,
2022
] | 3 | [] | [
"IPR022846"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"unclassified sequences"
] | [
11,
18288,
11580,
2,
389
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
13,
4,
4,
5,
2,
20,
4,
4,
5,
10,
2,
1,
20
] | 13 | true | Family | Xaa-Pro dipeptidase-like | Xaa-Pro dipeptidase-like | X-Pro_dipept-like | 4 |
IPR052434 | 52,434 | Tectonic-like complex component protein | Tectonic-like_complex_comp | Family | 3,447 | true | false | This family of proteins includes components of the tectonic-like complex, which is localized at the transition zone of primary cilia. These proteins play a crucial role in maintaining the ciliary structure and are essential for ciliogenesis. They act as a barrier to prevent the diffusion of transmembrane proteins betwe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR20837"
] | [
"Tectonic-like_complex_comp"
] | [
3447
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
3444,
3
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
17,
1,
14,
4,
7
] | 6 | true | Family | Tectonic-like complex component protein | Tectonic-like complex component protein | Tectonic-like_complex_comp | 6 |
IPR052435 | 52,435 | YY1-Associated Transcriptional Regulator | YY1-Transcr_Regul | Family | 3,844 | true | false | The protein family in question is involved in various cellular processes including chromatin remodeling, transcriptional regulation, DNA repair, replication, and cell cycle regulation. Members of the family are known to associate with complexes that include proteins such as YY1, SIN3A, and HDAC1, indicating a role in t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16088"
] | [
"YY1-Transcr_Regul"
] | [
3844
] | 1 | [] | [] | [] | 0 | [
"1ug2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomonospora nanhaiensis"
] | [
3843,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
9,
2,
5,
3,
48,
10,
3,
10,
7
] | 9 | true | Family | YY1-Associated Transcriptional Regulator | YY1-Associated Transcriptional Regulator | YY1-Transcr_Regul | 8 |
IPR052436 | 52,436 | LTO1 complex adapter protein | LTO1_adapter | Family | 3,585 | true | false | This family of proteins is involved in the biogenesis of the large ribosomal subunit and initiation of translation. Members of this family form a complex with YAE1 or its homologs, functioning as a target-specific adapter that recruits apo-ribosomal-like proteins to the cytosolic iron-sulfur protein assembly (CIA) mach... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28532"
] | [
"LTO1_adapter"
] | [
3585
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Hyperionvirus sp."
] | [
17,
3567,
1
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
8,
1,
1,
7,
6,
1,
2,
10,
1,
1,
14
] | 11 | true | Family | LTO1 complex adapter protein | LTO1 complex adapter protein | LTO1_adapter | 3 |
IPR052437 | 52,437 | Pectin Methylation Modulator | Pectin_Meth_Modulator | Family | 4,246 | true | false | This family of proteins is involved in the modulation of cell wall physiology, particularly through the regulation of pectin methylation status. Members of this family are implicated in various developmental processes, including seed germination, hypocotyl elongation, reproductive organ development, and embryo developm... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31265"
] | [
"Pectin_Meth_Modulator"
] | [
4246
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chroococcales",
"Streptophyta"
] | [
3,
4243
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
42,
46,
47
] | 3 | true | Family | Pectin Methylation Modulator | Pectin Methylation Modulator | Pectin_Meth_Modulator | 1 |
IPR052439 | 52,439 | F-box/kelch-repeat domain-containing protein | F-box/Kelch-repeat | Family | 3,870 | true | false | This family of proteins includes members that contain an F-box domain and often kelch repeats. The F-box domain is crucial for the interaction with SKP1-like (ASK) proteins, which are part of the SCF (SKP1-cullin-F-box) E3 ubiquitin ligase complex. These complexes play a significant role in the ubiquitination pathway, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46122"
] | [
"F-box/Kelch-repeat"
] | [
3870
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
3867,
3
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
17,
35
] | 3 | true | Family | F-box/kelch-repeat domain-containing protein | F-box/kelch-repeat domain-containing protein | F-box/Kelch-repeat | 5 |
IPR052440 | 52,440 | Transcriptional Regulator and Chromatin Remodeler | Trans_Reg/Chrom_Remod | Family | 3,278 | true | false | The protein family is involved in transcriptional regulation and chromatin remodeling. Members of the family function as transcriptional activators, interacting with various transcriptional activators and cofactors to modulate gene expression. They play roles in the regulation of the circadian clock by controlling the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14955"
] | [
"Trans_Reg/Chrom_Remod"
] | [
3278
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9707616",
"R-HSA-9931509"
] | [
"REACTOME:R-HSA-9707616",
"REACTOME:R-HSA-9931509"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3278
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
3,
9,
13,
5
] | 5 | true | Family | Transcriptional Regulator and Chromatin Remodeler | Transcriptional Regulator and Chromatin Remodeler | Trans_Reg/Chrom_Remod | 1 |
IPR052441 | 52,441 | Armadillo Repeat & Ser/Thr Protein Kinase | Armadillo-Ser/Thr_Kinase | Family | 3,446 | true | false | This family of proteins includes armadillo repeat-containing proteins involved in male fertility and sperm motility, specifically by promoting autophagic degradation of ribosomes during spermatogenesis to supply energy for sperm flagellar motility. Additionally, the family encompasses serine/threonine-protein kinases t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46618"
] | [
"Armadillo-Ser/Thr_Kinase"
] | [
3446
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3446
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
4,
1,
3,
4,
5,
5,
84
] | 8 | true | Family | Armadillo Repeat & Ser/Thr Protein Kinase | Armadillo Repeat & Ser/Thr Protein Kinase | Armadillo-Ser/Thr_Kinase | 3 |
IPR052442 | 52,442 | Environmental Response Regulator | Env_Response_Regulator | Family | 3,612 | true | false | This family of proteins includes transcription factors that are involved in the regulation of gene expression in response to environmental conditions. One member of this family acts as a negative regulator by controlling the expression of genes that are regulated by abscisic acid, which is a plant hormone that plays a ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46136"
] | [
"Env_Response_Regulator"
] | [
3612
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
3607
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
26,
18,
58
] | 3 | true | Family | Environmental Response Regulator | Environmental Response Regulator | Env_Response_Regulator | 2 |
IPR052443 | 52,443 | E3 ubiquitin-protein ligase RNF220-like | E3_ubiq-ligase_RNF220-like | Family | 3,303 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that are involved in the ubiquitination and subsequent proteasomal degradation of specific substrates, such as SIN3B. These proteins also function independently of their ligase activity, stabilizing CTNNB1 through deubiquitination mediated by USP7, which in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13459"
] | [
"E3_ubiq-ligase_RNF220-like"
] | [
3303
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-HSA-983168",
"R-MMU-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3303
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
59,
6,
7,
3,
6
] | 5 | true | Family | E3 ubiquitin-protein ligase RNF220-like | E3 ubiquitin-protein ligase RNF220-like | E3_ubiq-ligase_RNF220-like | 8 |
IPR052444 | 52,444 | Spaetzle/Toll ligand-like | Spz/Toll_ligand-like | Family | 3,583 | true | false | This family of proteins includes neurotrophins that function as ligands for Toll and Toll-related receptors, playing a pivotal role in the development and function of the central nervous system. They are involved in the establishment of dorsal-ventral polarity during embryonic development, motor axon targeting, neurona... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23199"
] | [
"Spz/Toll_ligand-like"
] | [
3583
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-209442",
"R-DME-214842",
"R-DME-214844",
"R-DME-214862",
"R-DME-214863",
"R-DME-214869",
"R-DME-214874"
] | [
"REACTOME:R-DME-209442",
"REACTOME:R-DME-214842",
"REACTOME:R-DME-214844",
"REACTOME:R-DME-214862",
"REACTOME:R-DME-214863",
"REACTOME:R-DME-214869",
"REACTOME:R-DME-214874"
] | 7 | [
"3e07",
"4bv4",
"4lxr",
"4lxs",
"7b1b",
"7b1c"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3583
] | 1 | [
"Drosophila melanogaster"
] | [
15
] | 1 | true | Family | Spaetzle/Toll ligand-like | Spaetzle/Toll ligand-like | Spz/Toll_ligand-like | 8 |
IPR052445 | 52,445 | ZNF804A-like/GPATCH8 | ZNF804A-like/GPATCH8 | Family | 3,041 | true | true | This entry represents G patch domain-containing protein 8 and Zinc finger protein 804A/B from animals. ZNF804A is localised to neuronal compartments, including dendritic spines, growth cones and synapses. ZNF804A protein is involved in positive regulation of neuron projection development and gene expression [ ]. GPATCH... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17614"
] | [
"ZnF-G_patch_domain"
] | [
3041
] | 1 | [
"REACTOME"
] | [
"R-HSA-212436"
] | [
"REACTOME:R-HSA-212436"
] | 1 | [] | 0 | [
"PUB00162438",
"PUB00163222",
"PUB00163223"
] | [
"38216065",
"21594610",
"38688280"
] | [
"Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism.",
"Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8.",
"GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malig... | [
2024,
2011,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3041
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
36,
8,
8,
9
] | 4 | true | Family | ZNF804A-like/GPATCH8 | ZNF804A-like/GPATCH8 | ZNF804A-like/GPATCH8 | 7 |
IPR052446 | 52,446 | B-cell PI3K Activation and Signaling Adapters | B-cell_PI3K-Signaling_Adptrs | Family | 3,089 | true | false | The protein family is involved in B-cell development and signaling, acting as an adapter linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt pathway. It supports BCR and PI3K activation by providing a docking site for PIK3R1 and complements the role of CD19. Additionally, it connects Tol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16267"
] | [
"B-cell_PI3K-Signaling_Adptrs"
] | [
3089
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-1257604",
"R-GGA-6811558",
"R-GGA-983695",
"R-HSA-1257604",
"R-HSA-2219530",
"R-HSA-6811558",
"R-HSA-983695",
"R-MMU-1257604",
"R-MMU-6811558",
"R-MMU-983695"
] | [
"REACTOME:R-GGA-1257604",
"REACTOME:R-GGA-6811558",
"REACTOME:R-GGA-983695",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-2219530",
"REACTOME:R-HSA-6811558",
"REACTOME:R-HSA-983695",
"REACTOME:R-MMU-1257604",
"REACTOME:R-MMU-6811558",
"REACTOME:R-MMU-983695"
] | 10 | [
"5for",
"6sws"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3089
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
4,
9,
10
] | 5 | true | Family | B-cell PI3K Activation and Signaling Adapters | B-cell PI3K Activation and Signaling Adapters | B-cell_PI3K-Signaling_Adptrs | 2 |
IPR052447 | 52,447 | Dermatan-Sulfate Isomerase | Dermatan-Sulfate_Isomerase | Family | 2,475 | true | false | The dermatan-sulfate isomerase family is involved in the biosynthesis of dermatan sulfate, a type of glycosaminoglycan/mucopolysaccharide. Members of this family are responsible for the conversion of D-glucuronic acid to L-iduronic acid (IdoUA) residues, a key step in the formation of dermatan sulfate. This process is ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15532"
] | [
"Dermatan-Sulfate_Isomerase"
] | [
2475
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"5.1.3.19",
"PWY-6568",
"R-HSA-2022923",
"R-MMU-2022923"
] | [
"EC:5.1.3.19",
"METACYC:PWY-6568",
"REACTOME:R-HSA-2022923",
"REACTOME:R-MMU-2022923"
] | 4 | [
"6hzn"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"bioreactor metagenome"
] | [
221,
2253,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
11,
5,
5
] | 4 | true | Family | Dermatan-Sulfate Isomerase | Dermatan-Sulfate Isomerase | Dermatan-Sulfate_Isomerase | 6 |
IPR052448 | 52,448 | DnaJ Homolog Subfamily C Member 16 | DnaJ_C16_autophagy_reg | Family | 3,305 | true | false | The DnaJ homolog subfamily C member 16 family is involved in the cellular autophagy process, specifically in the regulation of autophagosome size. Autophagosomes are key structures in autophagy, a mechanism by which cells degrade and recycle cytoplasmic components. The members of the DnaJ homolog subfamily C member 16 ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44303"
] | [
"DnaJ_C16_autophagy_reg"
] | [
3305
] | 1 | [] | [] | [] | 0 | [
"2cug"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Clostridium thermobutyricum",
"Eukaryota",
"viral metagenome"
] | [
2,
3302,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
2,
5,
2,
7,
2,
4,
3,
8
] | 9 | true | Family | DnaJ Homolog Subfamily C Member 16 | DnaJ Homolog Subfamily C Member 16 | DnaJ_C16_autophagy_reg | 9 |
IPR052449 | 52,449 | Serine/Threonine/Tyrosine-Interacting Phosphatase | STYX-Interacting_Phosphatase | Family | 2,988 | true | false | This family of proteins includes catalytically inactive phosphatases that interact with serine, threonine, and tyrosine residues. Members of this family function as nuclear anchors for MAPK1/MAPK3, also known as ERK1/ERK2, thereby modulating cell-fate decisions and cell migration through the spatiotemporal regulation o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46588"
] | [
"STYX-Interacting_Phosphatase"
] | [
2988
] | 1 | [] | [] | [] | 0 | [
"2r0b"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphabaculovirus",
"Eukaryota"
] | [
4,
2984
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
1,
8,
1,
6
] | 5 | true | Family | Serine/Threonine/Tyrosine-Interacting Phosphatase | Serine/Threonine/Tyrosine-Interacting Phosphatase | STYX-Interacting_Phosphatase | 6 |
IPR052450 | 52,450 | Telomeric Repeat-Binding Domain-Containing Protein | TRBD-Containing_Protein | Family | 2,970 | true | false | This family of proteins is involved in the regulation and protection of telomeres, the repetitive nucleotide sequences at the ends of chromosomes. Members of this family bind specifically to telomeric DNA sequences, playing a crucial role in maintaining telomere integrity and length. They are components of the shelteri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46734"
] | [
"TRBD-Containing_Protein"
] | [
2970
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-1221632",
"R-HSA-171306",
"R-HSA-171319",
"R-HSA-174411",
"R-HSA-174414",
"R-HSA-174417",
"R-HSA-174430",
"R-HSA-174437",
"R-HSA-2559586",
"R-HSA-9670095",
"R-MMU-110330",
"R-MMU-110331",
"R-MMU-171319",
"R-MMU-... | [
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-1221632",
"REACTOME:R-HSA-171306",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-174411",
"REACTOME:R-HSA-174414",
"REACTOME:R-HSA-174417",
"REACTOME:R-HSA-174430",
"REACTOME:R-HSA-17... | 25 | [
"1ba5",
"1h6o",
"1ity",
"1iv6",
"1w0t",
"3bqo",
"3l82",
"5wir",
"5xup",
"8f0a",
"8f0u",
"8f1t",
"8f1u",
"8f21",
"8f26",
"8ox1",
"8w8g"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudobutyrivibrio xylanivorans"
] | [
2969,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
10,
3,
1,
3,
1
] | 6 | true | Family | Telomeric Repeat-Binding Domain-Containing Protein | Telomeric Repeat-Binding Domain-Containing Protein | TRBD-Containing_Protein | 2 |
IPR052451 | 52,451 | Serine/threonine kinase-like | Ser/Thr_kinase-like | Family | 3,689 | true | false | This family of proteins includes serine/threonine kinases and putative kinases. Some members are predicted to be catalytically inactive due to the absence of conserved active site residues, yet they may retain other functional roles within the cell. One member is reported to phosphorylate specific substrates, suggestin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48008"
] | [
"Ser/Thr_kinase-like"
] | [
3689
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces achromogenes"
] | [
3688,
1
] | 2 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
20,
7,
4,
20,
6,
21
] | 6 | true | Family | Serine/threonine kinase-like | Serine/threonine kinase-like | Ser/Thr_kinase-like | 1 |
IPR052452 | 52,452 | Ankyrin repeat and MYND domain-containing protein 2 | Ankyrin-MYND_dom_contain_2 | Family | 2,090 | true | false | The Ankyrin repeat and MYND domain-containing protein 2 family is implicated in the cellular process of trafficking signaling proteins to cilia. Members of this family play a crucial role in the proper localization of signaling molecules, which is essential for the function of cilia in sensory perception and signal tra... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24150"
] | [
"Ankyrin-MYND_dom_contain_2"
] | [
2090
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2090
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
1,
4,
1,
4
] | 6 | true | Family | Ankyrin repeat and MYND domain-containing protein 2 | Ankyrin repeat and MYND domain-containing protein 2 | Ankyrin-MYND_dom_contain_2 | 5 |
IPR052453 | 52,453 | CONSTANS-like zinc finger regulators | CONSTANS-like_ZF | Family | 3,630 | true | false | This family of proteins includes members that are characterized by the presence of zinc finger domains, suggesting a role in DNA binding and regulation of gene expression. The CONSTANS-like proteins within this family are likely involved in the regulation of flowering time and other developmental processes in plants, a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31874"
] | [
"CONSTANS-like_ZF"
] | [
3630
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3630
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
48,
23,
42
] | 3 | true | Family | CONSTANS-like zinc finger regulators | CONSTANS-like zinc finger regulators | CONSTANS-like_ZF | 8 |
IPR052454 | 52,454 | Thioredoxin-related transmembrane domain-containing protein | TMX_domain-containing | Family | 2,713 | true | false | This family of proteins contains a thioredoxin domain and is involved in redox reactions, where it catalyzes the reversible oxidation of its active center dithiol to a disulfide and facilitates dithiol-disulfide exchange reactions. Members of this family inhibit an alternative triglyceride biosynthesis pathway, thus re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46107"
] | [
"TMX_domain-containing"
] | [
2713
] | 1 | [
"EC"
] | [
"5.3.4.1"
] | [
"EC:5.3.4.1"
] | 1 | [
"1x5e"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinocatenispora rupis",
"Eukaryota",
"uncultured organism MedDCM-OCT-S04-C12"
] | [
1,
2711,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
6,
6,
6,
10
] | 6 | true | Family | Thioredoxin-related transmembrane domain-containing protein | Thioredoxin-related transmembrane domain-containing protein | TMX_domain-containing | 3 |
IPR052455 | 52,455 | Tricalbin domain-containing protein | Tricalbin_domain | Family | 2,886 | true | false | This family of proteins may be involved in membrane trafficking processes. Members are characterized by the presence of C2 domains, which in some cases show Ca(2+)-dependent phospholipid binding, suggesting a role in membrane interactions and signaling. The C2 domains bind to various phospholipids, including phosphatid... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46980"
] | [
"Tricalbin_domain"
] | [
2886
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2886
] | 1 | [
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
3,
2
] | 4 | true | Family | Tricalbin domain-containing protein | Tricalbin domain-containing protein | Tricalbin_domain | 2 |
IPR052458 | 52,458 | Polycomb group PRC1-like complex component | PcG_PRC1-like_component | Family | 2,553 | true | false | This family of proteins includes components of Polycomb group (PcG) multiprotein PRC1-like complexes, which are essential for maintaining the transcriptionally repressive state of various genes, such as Hox genes, during development. These proteins are involved in chromatin remodeling and histone modification, specific... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46389"
] | [
"PcG_PRC1-like_component"
] | [
2553
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-2559580",
"R-DME-3108214",
"R-DME-3899300",
"R-DME-4570464",
"R-DME-8939243",
"R-DME-8943724",
"R-HSA-2559580",
"R-HSA-3108214",
"R-HSA-3899300",
"R-HSA-4551638",
"R-HSA-4570464",
"R-HSA-4655427",
"R-HSA-8939243",
"R-HSA-8943724",
"R-MMU-3108214",
"R-MMU-3899300",
"R-MMU-45516... | [
"REACTOME:R-DME-2559580",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3899300",
"REACTOME:R-DME-4570464",
"REACTOME:R-DME-8939243",
"REACTOME:R-DME-8943724",
"REACTOME:R-HSA-2559580",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-3899300",
"REACTOME:R-HSA-4551638",
"REACTOME:R-HSA-4570464",
"REACTOM... | 19 | [
"1pdq",
"1pfb",
"2dnv",
"3gv6",
"3i90",
"3i91",
"5eq0"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pediococcus pentosaceus"
] | [
2552,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
2,
6,
9,
7
] | 5 | true | Family | Polycomb group PRC1-like complex component | Polycomb group PRC1-like complex component | PcG_PRC1-like_component | 2 |
IPR052459 | 52,459 | Tumor necrosis factor receptor superfamily decoy receptor | TNFRSF_decoy_receptor | Family | 2,615 | true | false | This family of proteins includes decoy receptors that interact with various tumor necrosis factor superfamily ligands. They play a crucial role in regulating osteoclastogenesis by acting as decoy receptors for TNFSF11/RANKL, neutralizing its function and inhibiting osteoclast activation. These proteins are also involve... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23097"
] | [
"TNFRSF_decoy_receptor"
] | [
2615
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5669034",
"R-HSA-5669034",
"R-MMU-5669034",
"R-RNO-5669034"
] | [
"REACTOME:R-BTA-5669034",
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034",
"REACTOME:R-RNO-5669034"
] | 4 | [
"3k51",
"3mhd",
"3mi8",
"3urf",
"4e4d",
"4j6g",
"4kgg",
"4kgq",
"4msv",
"5l36"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bradymonadales",
"Eukaryota",
"Viruses"
] | [
3,
2590,
22
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
3,
4
] | 4 | true | Family | Tumor necrosis factor receptor superfamily decoy receptor | Tumor necrosis factor receptor superfamily decoy receptor | TNFRSF_decoy_receptor | 7 |
IPR052460 | 52,460 | Endoplasmic reticulum disulfide reductase | ER_disulfide_reductase | Family | 2,345 | true | false | This family of proteins functions as endoplasmic reticulum disulfide reductases, playing a crucial role in protein homeostasis. They are involved in the correct folding of nascent proteins by catalyzing the reduction of non-native disulfide bonds, as well as in the degradation of misfolded proteins through the endoplas... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44340"
] | [
"ER_disulfide_reductase"
] | [
2345
] | 1 | [
"EC"
] | [
"1.8.4.2"
] | [
"EC:1.8.4.2"
] | 1 | [
"3apo",
"3apq",
"3aps",
"5ayk",
"5ayl"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Klebsiella pneumoniae"
] | [
2344,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
18,
3,
5
] | 5 | true | Family | Endoplasmic reticulum disulfide reductase | Endoplasmic reticulum disulfide reductase | ER_disulfide_reductase | 4 |
IPR052461 | 52,461 | EVA1 A/B | EVA1_A/B | Family | 2,199 | false | false | This entry represents the EVA1 A and B. EVA1A, also known as TMEM166, regulates cell autophagy and apoptosis, which are essential for maintaining cellular homeostasis and responding to cellular stress [ , ]. EVA1A has also been shown to promote papillary thyroid cancer progression and epithelial-mesenchymal transition ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48422"
] | [
""
] | [
2199
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275"
] | 2 | [] | 0 | [
"PUB00089726",
"PUB00089727",
"PUB00155231"
] | [
"17492404",
"27490928",
"7701523"
] | [
"TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis.",
"TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death.",
"Effect of sympathetic nervous system stimulation on cerebrovascular CO2 responsiveness."
] | [
2007,
2016,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2199
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
5,
5,
7
] | 4 | true | Family | EVA1 A/B | EVA1 A/B | EVA1_A/B | 6 |
IPR052462 | 52,462 | SRA stem-loop-interacting RNA-binding protein/Glycine-rich RNA-binding-like | SLIRP/GR-RBP-like | Family | 25,205 | true | true | This family comprises RNA-binding proteins with roles in RNA transcription or processing, particularly under stress conditions [ , , ]. Some members of the family are involved in C-to-U editing of mitochondrial RNA, with some controlling a significant proportion of mitochondrial editing sites [ , ]. They exhibit a stro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48027"
] | [
"GR-RBP"
] | [
25205
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9836573",
"R-HSA-9937008"
] | [
"REACTOME:R-HSA-9836573",
"REACTOME:R-HSA-9937008"
] | 2 | [
"1x4e",
"2cpf",
"2ki2",
"7csx",
"7csz",
"7jly",
"8any",
"9evs",
"9gyt"
] | 9 | [
"PUB00077702",
"PUB00082774",
"PUB00148884",
"PUB00155111",
"PUB00155112"
] | [
"12220514",
"16762838",
"17376161",
"28549172",
"31812689"
] | [
"cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.",
"SLIRP, a small SRA binding protein, is a nuclear receptor corepressor.",
"Functional characterization of a glycine-rich RNA-binding protein 2 in Arabidopsis thaliana under abiotic stress conditions.",
"ORRM5, a... | [
2002,
2006,
2007,
2017,
2020
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
15,
6960,
18045,
185
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
58,
2,
4,
3,
10,
4,
4,
37,
10,
2,
99
] | 11 | true | Family | SRA stem-loop-interacting RNA-binding protein/Glycine-rich RNA-binding-like | SRA stem-loop-interacting RNA-binding protein/Glycine-rich RNA-binding-like | SLIRP/GR-RBP-like | 1 |
IPR052464 | 52,464 | Synovial Proliferation Regulator | Synovial_Prolif_Regulator | Family | 3,764 | true | false | This family of proteins is involved in cellular responses to inflammatory stimuli. Members of this family are known to contribute to the proliferation of cells, particularly synovial fibroblasts, under such conditions. The role of these proteins is crucial in the regulation of inflammatory processes and may have implic... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23424"
] | [
"Synovial_Prolif_Regulator"
] | [
3764
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3000471",
"R-HSA-416476",
"R-HSA-418594",
"R-HSA-444473",
"R-HSA-445989",
"R-HSA-6785807",
"R-HSA-879415",
"R-HSA-933542",
"R-HSA-977225"
] | [
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-444473",
"REACTOME:R-HSA-445989",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-879415",
"REACTOME:R-HSA-933542",
"REACTOME:R-HSA-977225"
] | 9 | [
"4ip8",
"4ip9",
"4q5g",
"6dso",
"6mst",
"6pxz",
"6py0",
"6zcf",
"6zcg",
"6zch",
"7ovt",
"7zh7",
"7zky",
"9r4z"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3764
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
4,
1,
19,
13,
4,
9,
4
] | 8 | true | Family | Synovial Proliferation Regulator | Synovial Proliferation Regulator | Synovial_Prolif_Regulator | 2 |
IPR052465 | 52,465 | Mitochondrial NAD+ Carrier | Mito_NAD+_Carrier | Family | 2,237 | true | false | This family of proteins includes mitochondrial membrane carrier proteins that are involved in the transport of nicotinamide adenine dinucleotide (NAD+) into the mitochondria. These proteins play a role in cellular metabolism by facilitating the import of NAD+, which is necessary for processes such as glycolysis and mit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46131"
] | [
"Mito_NAD+_Carrier"
] | [
2237
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-196807",
"R-MMU-196807",
"R-RNO-196807"
] | [
"REACTOME:R-HSA-196807",
"REACTOME:R-MMU-196807",
"REACTOME:R-RNO-196807"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2237
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
5,
8,
7
] | 6 | true | Family | Mitochondrial NAD+ Carrier | Mitochondrial NAD+ Carrier | Mito_NAD+_Carrier | 9 |
IPR052466 | 52,466 | DNA Methylation Protection Complex | DNA_MethProtect_Complex | Family | 2,183 | true | false | The protein family is involved in the protection and maintenance of transcriptional and developmental programs. It has a crucial role in safeguarding bivalent promoters and poised enhancers from hypermethylation, with a distinct preference for these regulatory elements. The family members function by forming a complex ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14709"
] | [
"DNA_MethProtect_Complex"
] | [
2183
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"bird metagenome"
] | [
2181,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
7,
6,
7
] | 4 | true | Family | DNA Methylation Protection Complex | DNA Methylation Protection Complex | DNA_MethProtect_Complex | 5 |
IPR052467 | 52,467 | Sorting nexin PX domain-containing protein | Sorting_nexin_PX-domain | Family | 2,154 | true | false | This family of proteins is involved in intracellular trafficking, indicating a role in the transport and sorting of molecules within the cell. Members of this family are characterized by the presence of a PX domain, which is known to bind specifically to phosphatidylinositol 3-phosphate (PtdIns(P3)) enriched membranes.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15813"
] | [
"Sorting_nexin_PX-domain"
] | [
2154
] | 1 | [] | [] | [] | 0 | [
"2ett",
"4az9"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2154
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
2,
9
] | 4 | true | Family | Sorting nexin PX domain-containing protein | Sorting nexin PX domain-containing protein | Sorting_nexin_PX-domain | 7 |
IPR052469 | 52,469 | Meiosis-specific OB domain-containing | MEIOB | Family | 2,030 | true | false | The MEIOB family comprises single-stranded DNA-binding proteins that play a crucial role in meiosis, particularly in homologous recombination during meiosis I. Members of the MEIOB family are essential for the repair of double strand breaks (DSBs) and the formation of crossovers, which are vital for the accurate segreg... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21166"
] | [
"MEIOB"
] | [
2030
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2030
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
1,
4,
3,
1,
3
] | 6 | true | Family | Meiosis-specific OB domain-containing | Meiosis-specific OB domain-containing | MEIOB | 8 |
IPR052471 | 52,471 | Protease B Inhibitor I9 | PBI_I9 | Family | 2,371 | true | false | This family of proteins includes cytosolic inhibitors of vacuolar proteinase B, which are likely involved in regulating protease B activity during limited proteolysis. Members of this family are also components of the LMA1 complex, which plays a role in facilitating vesicle fusion processes, including homotypic vacuole... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28288"
] | [
"PBI_I9"
] | [
2371
] | 1 | [] | [] | [] | 0 | [
"1itp",
"1v5i"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2371
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
2,
1
] | 3 | true | Family | Protease B Inhibitor I9 | Protease B Inhibitor I9 | PBI_I9 | 3 |
IPR052472 | 52,472 | MORN repeat-containing protein 3 | MORN3 | Family | 1,859 | true | false | This entry represents the MORN repeat-containing protein 3 (MORN3) family. Human MORN3 is involved in the regulation of the tumor suppressor p53/TP53 through the assembly of a Morn3-mediated protein complex (referred to as suppresome). MORN3 functions by tethering the enzymes SIRT1 and MDM2 to p53/TP53, leading to its ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46511"
] | [
"MORN3"
] | [
1859
] | 1 | [] | [] | [] | 0 | [
"7jts",
"7ju4",
"8glv",
"8j07",
"9e5c",
"9fqr"
] | 6 | [
"PUB00163405",
"PUB00163406"
] | [
"25248657",
"29681526"
] | [
"Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.",
"A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity."
] | [
2015,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pandoravirus",
"metagenomes"
] | [
45,
1803,
6,
5
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
1,
2,
3
] | 5 | true | Family | MORN repeat-containing protein 3 | MORN repeat-containing protein 3 | MORN3 | 9 |
IPR052473 | 52,473 | Mitochondrial Large Ribosomal Subunit mL53 | mtLSU_mL53 | Family | 2,115 | true | false | This family of proteins is involved in the assembly and function of the mitochondrial ribosome, which is responsible for protein synthesis within mitochondria. These proteins are part of the large ribosomal subunit and play a role in the translation of mitochondrial-encoded mRNAs, essential for the production of compon... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33618"
] | [
"mtLSU_mL53"
] | [
2115
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 10 | [
"3j7y",
"3j9m",
"4v1a",
"5aj4",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6xyw",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5h",
"7a5i",
"7a5j",
"7a5k",
"7l08"... | 91 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2115
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
1,
2,
1,
1,
2,
1,
4
] | 9 | true | Family | Mitochondrial Large Ribosomal Subunit mL53 | Mitochondrial Large Ribosomal Subunit mL53 | mtLSU_mL53 | 7 |
IPR052474 | 52,474 | UDP-N-acetylglucosamine transferase subunit | UDP-GlcNAc_transferase | Family | 1,980 | true | false | This family of proteins includes UDP-N-acetylglucosamine transferase subunits that are essential components in the pathway of protein N-glycosylation. They play a crucial role in the second step of the dolichol-linked oligosaccharide pathway, which is a fundamental process for the proper folding and stability of many p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47043"
] | [
"UDP-GlcNAc_transferase"
] | [
1980
] | 1 | [
"EC"
] | [
"2.4.1.141"
] | [
"EC:2.4.1.141"
] | 1 | [
"2jzc",
"2ks6"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bioreactor metagenome"
] | [
127,
1852,
1
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
2,
3,
1,
12
] | 5 | true | Family | UDP-N-acetylglucosamine transferase subunit | UDP-N-acetylglucosamine transferase subunit | UDP-GlcNAc_transferase | 8 |
IPR052475 | 52,475 | Wnt Signal Transduction Protein | Wnt_Signal_Transd_Protein | Family | 1,936 | true | false | This family of proteins is involved in the Wnt signaling pathway, a critical mechanism for regulating gene expression and cell behavior. Members of this family play a role in transmitting signals received from Wnt proteins to the intracellular environment, influencing various developmental processes and cell fate decis... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23194"
] | [
"Wnt_Signal_Transd_Protein"
] | [
1936
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-201722",
"R-DME-209407",
"R-DME-209421",
"R-HSA-201722",
"R-HSA-3769402",
"R-MMU-201722"
] | [
"REACTOME:R-DME-201722",
"REACTOME:R-DME-209407",
"REACTOME:R-DME-209421",
"REACTOME:R-HSA-201722",
"REACTOME:R-HSA-3769402",
"REACTOME:R-MMU-201722"
] | 6 | [
"2dx8",
"2vp7",
"2vpb",
"2vpd",
"2vpe",
"2vpg",
"2xb1",
"2yyr",
"3zpv",
"4up0",
"4up5"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10)"
] | [
1935,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
2,
5,
4,
4
] | 6 | true | Family | Wnt Signal Transduction Protein | Wnt Signal Transduction Protein | Wnt_Signal_Transd_Protein | 9 |
IPR052476 | 52,476 | Ubiquitin-associated domain-containing protein 1 | UBAC1 | Family | 1,870 | false | false | This entry represents UBAC1 and related proteins found in eukaryotes. Ubiquitin-associated domain-containing protein 1 (UBAC1) proteins include non-catalytic components of the KPC complex, a specific type of E3 ubiquitin-protein ligase complex. Members of this group function as adaptors within the KPC complex, facilita... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46738"
] | [
""
] | [
1870
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168",
"R-RNO-983168",
"R-XTR-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-983168",
"REACTOME:R-XTR-983168"
] | 4 | [
"2dai",
"2lbc"
] | 2 | [
"PUB00086162",
"PUB00135879"
] | [
"15531880",
"16227581"
] | [
"Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.",
"Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle."
] | [
2004,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1870
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
5,
2,
4,
8
] | 5 | true | Family | Ubiquitin-associated domain-containing protein 1 | Ubiquitin-associated domain-containing protein 1 | UBAC1 | 7 |
IPR052477 | 52,477 | Orphan G-protein coupled receptor 1 | Orphan_GPCR1 | Family | 1,744 | true | false | This family of proteins includes G-protein coupled receptors (GPCRs) that are classified as orphan receptors, which means their endogenous ligands have not been identified. Members of this family are thought to signal through a G(q/11)-mediated pathway, although the specific biological processes they regulate remain to... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46272"
] | [
"Orphan_GPCR1"
] | [
1744
] | 1 | [] | [] | [] | 0 | [
"7vug",
"7vuh",
"7vui",
"7vuj"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1744
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
9,
7,
4
] | 4 | true | Family | Orphan G-protein coupled receptor 1 | Orphan G-protein coupled receptor 1 | Orphan_GPCR1 | 6 |
IPR052478 | 52,478 | Transcriptional Regulators of Metabolite Synthesis | Metabolite_Synth_Reg | Family | 1,678 | true | false | This family of proteins includes transcription factors and probable transcriptional repressors. Members are involved in the regulation of gene clusters responsible for the biosynthesis of specific secondary metabolites, such as kojic acid, which is a by-product of the fermentation process and acts as a chelation agent.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31779"
] | [
"Metabolite_Synth_Reg"
] | [
1678
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1678
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Transcriptional Regulators of Metabolite Synthesis | Transcriptional Regulators of Metabolite Synthesis | Metabolite_Synth_Reg | 9 |
IPR052480 | 52,480 | Receptor-associated synaptic protein | RAPsyn | Family | 1,708 | true | false | This family of proteins is involved in the postsynaptic clustering of nicotinic acetylcholine receptors at the neuromuscular junction. Members of this family may interact with the postsynaptic cytoskeleton, potentially through direct association with actin or spectrin. They contain a cysteine-rich region that is homolo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46574"
] | [
"RAPsyn"
] | [
1708
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pyrococcus horikoshii",
"ecological metagenomes"
] | [
29,
1675,
1,
3
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
8,
3,
5
] | 6 | true | Family | Receptor-associated synaptic protein | Receptor-associated synaptic protein | RAPsyn | 6 |
IPR052481 | 52,481 | Double zinc ribbon and ankyrin repeat-containing protein | DZAN1 | Family | 1,550 | true | false | This family of proteins is involved in the intracellular transport of organelles and vesicles, particularly within photoreceptor cells. Members of this family play a crucial role in the formation, maintenance, and function of the photoreceptor's outer segments, which are essential for the conversion of light into elect... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16058"
] | [
"DZAN1"
] | [
1550
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacterium"
] | [
15,
1533,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
13,
5,
4
] | 4 | true | Family | Double zinc ribbon and ankyrin repeat-containing protein | Double zinc ribbon and ankyrin repeat-containing protein | DZAN1 | 7 |
IPR052482 | 52,482 | Mitochondrial large ribosomal subunit mL37 | mtLSU_mL37 | Family | 1,701 | true | false | This family of proteins is involved in the assembly and function of the mitochondrial ribosome, which is responsible for protein synthesis within mitochondria. These proteins are part of the large ribosomal subunit and are specific to the mitochondria, reflecting their specialized roles in mitochondrial gene expression... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15889"
] | [
"mtLSU_mL37"
] | [
1701
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383",
"R-RNO-5389840",
"R-RNO-5419276",
"R-RNO-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383",
"REACTOME:R-RNO-5389840",
"REACTOM... | 13 | [
"3j7y",
"3j9m",
"4v1a",
"5aj4",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse",
"6zsg",
"7a5f",
"7a5g",
"7a5h",
"7a5i",
"7a5j",
"7a5k",
"7l08",
"7l20"... | 91 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1701
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
5,
1,
3
] | 6 | true | Family | Mitochondrial large ribosomal subunit mL37 | Mitochondrial large ribosomal subunit mL37 | mtLSU_mL37 | 1 |
IPR052483 | 52,483 | Basic leucine zipper transcription regulators | bZIP_transcription_regulators | Family | 2,192 | true | false | This family of proteins includes transcriptional activators and regulators. Members of this family are involved in various cellular processes, including the control of cell wall patterning, pollen development, metabolic pathways, cellular transport, and lipid metabolism. They share a basic leucine zipper domain, which ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46391"
] | [
"bZIP_transcription_regulators"
] | [
2192
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2192
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
6,
22
] | 3 | true | Family | Basic leucine zipper transcription regulators | Basic leucine zipper transcription regulators | bZIP_transcription_regulators | 4 |
IPR052484 | 52,484 | Centromere Protein W/WIP1 | CENP-W/WIP1 | Family | 1,628 | true | false | The CENP-W/WIP1 family is involved in the essential processes of kinetochore assembly, mitotic progression, and chromosome segregation. Family members are components of the CENPA-NAC complex, which is crucial for assembling kinetochore proteins and may assist in the integration of newly synthesized CENPA into centromer... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34832"
] | [
"CENP-W/WIP1"
] | [
1628
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-606279",
"R-HSA-606279",
"R-MMU-606279",
"R-RNO-606279"
] | [
"REACTOME:R-GGA-606279",
"REACTOME:R-HSA-606279",
"REACTOME:R-MMU-606279",
"REACTOME:R-RNO-606279"
] | 4 | [
"3b0c",
"3b0d",
"3vh5",
"3vh6",
"7qoo",
"7r5s",
"7xhn",
"7xho",
"7ywx"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1628
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
7,
2,
3,
1,
3,
1
] | 6 | true | Family | Centromere Protein W/WIP1 | Centromere Protein W/WIP1 | CENP-W/WIP1 | 1 |
IPR052485 | 52,485 | MEGF-related differentiation regulators | MEGF_diff_regulators | Family | 3,238 | true | false | This family of proteins includes members that are involved in various cellular differentiation processes. Some proteins in this family are implicated in the regulation of platelet activation and hematopoiesis through interactions with specific ligands and activation of downstream signaling pathways such as AKT/mTOR. Ot... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24052"
] | [
"MEGF_diff_regulators"
] | [
3238
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota",
"bird metagenome"
] | [
6,
3231,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
12,
11,
8
] | 5 | true | Family | MEGF-related differentiation regulators | MEGF-related differentiation regulators | MEGF_diff_regulators | 8 |
IPR052486 | 52,486 | Phosphate transporter PHO1 | PHO1 | Family | 2,008 | false | false | PHO1 is characterised by its role in inorganic phosphate (Pi) transport and homeostasis in plants. It is involved in various aspects of Pi handling, including sensing Pi starvation [ ], exporting Pi out of cells [ , ], and transferring Pi between different plant tissues such as roots and shoots [ , ]. It contains an SP... | [
"GO:0016036"
] | [
"cellular response to phosphate starvation"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR48477"
] | [
""
] | [
2008
] | 1 | [] | [] | [] | 0 | [
"9ik4",
"9jf8"
] | 2 | [
"PUB00082650",
"PUB00132161",
"PUB00155261",
"PUB00155262",
"PUB00155263",
"PUB00155264"
] | [
"22612335",
"21309867",
"11971143",
"17461783",
"22449068",
"27080106"
] | [
"PHO1 expression in guard cells mediates the stomatal response to abscisic acid in Arabidopsis.",
"Over-expression of PHO1 in Arabidopsis leaves reveals its role in mediating phosphate efflux.",
"Identification and characterization of the Arabidopsis PHO1 gene involved in phosphate loading to the xylem.",
"Me... | [
2012,
2011,
2002,
2007,
2012,
2016
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2008
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
6,
19
] | 3 | true | Family | Phosphate transporter PHO1 | Phosphate transporter PHO1 | PHO1 | 3 |
IPR052487 | 52,487 | Galactose-binding lectin | Galactose-binding_lectin | Family | 1,116 | true | false | This family of proteins includes galactose- and N-acetylgalactosamine-binding lectins that are implicated in cell-substratum adhesion processes. Members of this family are thought to contribute to the maintenance of cell morphology during certain stages of cell aggregation. Additionally, some proteins within this famil... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46938"
] | [
"Galactose-binding_lectin"
] | [
1116
] | 1 | [] | [] | [] | 0 | [
"2ce6",
"2cgy",
"2cgz",
"2vm9",
"2vmc",
"2vmd",
"2vme",
"2w94",
"2w95",
"2wn2",
"2wn3"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
513,
598,
5
] | 3 | [] | [] | 0 | true | Family | Galactose-binding lectin | Galactose-binding lectin | Galactose-binding_lectin | 5 |
IPR052488 | 52,488 | Diencephalon/mesencephalon homeobox | DMBX_homeobox | Family | 1,520 | true | false | The Diencephalon/mesencephalon homeobox protein family is characterized by its role in transcriptional repression and developmental processes in vertebrates. Members of the family are known to function as transcriptional repressors, with some forming heterodimers with OTX2 to repress OTX2-mediated transactivation on sp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46639"
] | [
"DMBX_homeobox"
] | [
1520
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1520
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
1,
2
] | 4 | true | Family | Diencephalon/mesencephalon homeobox | Diencephalon/mesencephalon homeobox | DMBX_homeobox | 8 |
IPR052489 | 52,489 | Leucine-rich repeat and WD repeat-containing protein 1 | LRWD1 | Family | 1,404 | true | false | The LRWD1 family proteins are essential for the G1/S transition of the cell cycle. They recruit and stabilize the origin recognition complex (ORC) onto chromatin during G1 to establish the pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Members of the LRWD1 family bind a combinati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24370"
] | [
"LRWD1"
] | [
1404
] | 1 | [] | [] | [] | 0 | [
"8siu",
"8siy"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1404
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
6,
3,
4
] | 5 | true | Family | Leucine-rich repeat and WD repeat-containing protein 1 | Leucine-rich repeat and WD repeat-containing protein 1 | LRWD1 | 1 |
IPR052490 | 52,490 | Calcineurin B Homologous Protein 3 | CHP3 | Family | 1,324 | true | false | The Calcineurin B Homologous Protein 3 family plays a crucial role in cellular pH regulation by modulating plasma membrane-type Na(+)/H(+) exchange activity. It is involved in hematopoietic stem cell differentiation, particularly towards the megakaryocytic lineage, and is essential for linking ERK cascade activation to... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46823"
] | [
"CHP3"
] | [
1324
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata",
"bird metagenome"
] | [
1323,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
5,
11
] | 4 | true | Family | Calcineurin B Homologous Protein 3 | Calcineurin B Homologous Protein 3 | CHP3 | 1 |
IPR052491 | 52,491 | Tumor necrosis factor receptor superfamily member 10 | TNFRSF10 | Family | 2,095 | true | false | This family of proteins includes receptors that interact with the cytotoxic ligand TNFSF10/TRAIL. Members of this family can initiate apoptosis through the formation of a death-inducing signaling complex (DISC) that activates caspase-8 and subsequent caspases. Some members contain a truncated death domain and do not in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46330"
] | [
"TNFRSF10"
] | [
2095
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140534",
"R-HSA-202733",
"R-HSA-3371378",
"R-HSA-5213460",
"R-HSA-5218900",
"R-HSA-6803211",
"R-HSA-69416",
"R-HSA-75158",
"R-MMU-202733",
"R-MMU-3371378",
"R-MMU-5218900",
"R-MMU-69416",
"R-MMU-75158"
] | [
"REACTOME:R-HSA-140534",
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3371378",
"REACTOME:R-HSA-5213460",
"REACTOME:R-HSA-5218900",
"REACTOME:R-HSA-6803211",
"REACTOME:R-HSA-69416",
"REACTOME:R-HSA-75158",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-3371378",
"REACTOME:R-MMU-5218900",
"REACTOME:R-MMU... | 13 | [
"1d0g",
"1d4v",
"1du3",
"1za3",
"2h9g",
"3x3f",
"4i9x",
"4n90",
"4od2",
"5cir",
"6t3j",
"8dpx"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Sandaracinus amylolyticus"
] | [
2094,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
17,
11,
8
] | 4 | true | Family | Tumor necrosis factor receptor superfamily member 10 | Tumor necrosis factor receptor superfamily member 10 | TNFRSF10 | 1 |
IPR052492 | 52,492 | Tubulin--tyrosine ligase | Tubulin-tyrosine_ligase | Family | 1,154 | true | false | This family of proteins is responsible for the enzymatic activity that attaches a tyrosine residue to the C-terminal end of detyrosinated alpha-tubulin. This post-translational modification is crucial for the restoration of alpha-tubulin's tyrosine residue, which is important for the polymerization and function of micr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46570"
] | [
"Tubulin-tyrosine_ligase"
] | [
1154
] | 1 | [
"EC",
"REACTOME"
] | [
"6.3.2.25",
"R-HSA-8955332"
] | [
"EC:6.3.2.25",
"REACTOME:R-HSA-8955332"
] | 2 | [
"3tig",
"3tii",
"3tin",
"4i4t",
"4i50",
"4i55",
"4ihj",
"4iij",
"4o2a",
"4o2b",
"4o4h",
"4o4i",
"4o4j",
"4o4l",
"4tuy",
"4tv8",
"4tv9",
"4yj2",
"4yj3",
"4zhq",
"4zi7",
"4zol",
"5bmv",
"5c8y",
"5ca0",
"5ca1",
"5cb4",
"5ezy",
"5fnv",
"5gon",
"5h74",
"5h7o"... | 290 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Marseillevirus LCMAC102",
"Pseudomonadati",
"viral metagenome"
] | [
1140,
1,
11,
2
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
5
] | 4 | true | Family | Tubulin--tyrosine ligase | Tubulin--tyrosine ligase | Tubulin-tyrosine_ligase | 3 |
IPR052493 | 52,493 | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A | Family | 1,171 | true | false | This family of proteins includes receptors that bind to tumor necrosis factors such as TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. Upon ligand binding, these receptors recruit the adapter molecule FADD, which in turn recruits caspase-8 to form the death-inducing signaling complex (DISC). Activation of c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46861"
] | [
"TNFRSF1A"
] | [
1171
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-HSA-5626978",
"R-HSA-5669034",
"R-HSA-6783783",
"R-HSA-75893",
"R-MMU-5357786",
"R-MMU-5357905",
"R-MMU-5357956",
"R-MMU-5626978",
"R-MMU-5669034",
"R-MMU-75893",
"R-RNO-5357786",
"R-RNO-5357905",
"R-RNO-5357956",
"R-RNO-5626978",... | [
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-5357956",
"REACTOME:R-HSA-5626978",
"REACTOME:R-HSA-5669034",
"REACTOME:R-HSA-6783783",
"REACTOME:R-HSA-75893",
"REACTOME:R-MMU-5357786",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-5357956",
"REACTOME:R-MMU-5626978",
"REACTOME:... | 19 | [
"1ext",
"1ft4",
"1ich",
"1ncf",
"1tnr",
"7kp7",
"7kp8",
"7kpb",
"8p6q",
"8zui"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyprinid herpesvirus 3",
"Eumetazoa"
] | [
2,
1169
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
10,
9,
5
] | 4 | true | Family | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A | 4 |
IPR052494 | 52,494 | Flagella-assembly related protein | Flagella_assembly_related | Family | 710 | true | false | This family of proteins is involved in the structure and function of flagella, which are whip-like appendages that enable motility in various microorganisms. Members of this family are implicated in the assembly or stability of the flagellar apparatus. They may interact with each other, suggesting a coordinated role in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40698"
] | [
"Flagella_assembly_related"
] | [
710
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"candidate division WOR-3 bacterium",
"unclassified sequences"
] | [
705,
2,
3
] | 3 | [] | [] | 0 | true | Family | Flagella-assembly related protein | Flagella-assembly related protein | Flagella_assembly_related | 6 |
IPR052495 | 52,495 | Protein EARLY STARVATION 1-like | ESV1-like | Family | 1,423 | true | true | This family of proteins includes Protein EARLY STARVATION 1 and its homologues from plants. It is involved in the binding and organisation of alpha-glucans, particularly starch and crystalline maltodextrins, within the chloroplasts [ , ]. Members of this family play a crucial role in starch metabolism by affecting the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34113"
] | [
"Alpha-glucan_binding_chloro"
] | [
1423
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162125",
"PUB00162489",
"PUB00162490"
] | [
"27207856",
"29681129",
"35665549"
] | [
"The Starch Granule-Associated Protein EARLY STARVATION1 Is Required for the Control of Starch Degradation in Arabidopsis thaliana Leaves.",
"EARLY STARVATION1 specifically affects the phosphorylation action of starch-related dikinases.",
"LIKE EARLY STARVATION 1 alters the glucan structures at the starch granu... | [
2016,
2018,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1423
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
7,
18
] | 3 | true | Family | Protein EARLY STARVATION 1-like | Protein EARLY STARVATION 1-like | ESV1-like | 9 |
IPR052496 | 52,496 | Orphan Nuclear Receptor | Orphan_Nuclear_Rcpt | Family | 1,021 | true | false | This family of proteins includes members that are classified as orphan nuclear receptors. Orphan receptors are a type of nuclear hormone receptor for which endogenous ligands have not yet been identified. They are capable of DNA binding and may be involved in the regulation of gene expression, development, metabolism, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47519"
] | [
"Orphan_Nuclear_Rcpt"
] | [
1021
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-200425",
"R-CEL-381340",
"R-CEL-383280",
"R-CEL-400206",
"R-CEL-4090294",
"R-CEL-5362517",
"R-CEL-9616222",
"R-CEL-9841922"
] | [
"REACTOME:R-CEL-200425",
"REACTOME:R-CEL-381340",
"REACTOME:R-CEL-383280",
"REACTOME:R-CEL-400206",
"REACTOME:R-CEL-4090294",
"REACTOME:R-CEL-5362517",
"REACTOME:R-CEL-9616222",
"REACTOME:R-CEL-9841922"
] | 8 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
1021
] | 1 | [
"Caenorhabditis elegans"
] | [
13
] | 1 | true | Family | Orphan Nuclear Receptor | Orphan Nuclear Receptor | Orphan_Nuclear_Rcpt | 7 |
IPR052497 | 52,497 | H2.0 Homeobox Transcription Factors | H2.0_Homeobox_TF | Family | 1,115 | true | false | The H2.0 homeobox family comprises transcription factors that are pivotal in the maturation and maintenance of Th1 cells through TBX21/T-bet dependency. Members of this family are also involved in key developmental processes including embryogenesis and hematopoiesis. In Drosophila, they may contribute to pattern format... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46808"
] | [
"H2.0_Homeobox_TF"
] | [
1115
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1115
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
3,
4,
3
] | 5 | true | Family | H2.0 Homeobox Transcription Factors | H2.0 Homeobox Transcription Factors | H2.0_Homeobox_TF | 9 |
IPR052498 | 52,498 | E3 ubiquitin-protein ligase RNF138 | E3_ubiq-protein_ligase_RNF138 | Family | 953 | true | false | The RNF138 ubiquitin-protein ligase family is involved in the cellular response to DNA damage, particularly in promoting DNA resection and homologous recombination for the repair of double-strand breaks. Members of this family are recruited to damaged DNA sites and facilitate repair through homologous recombination, po... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46968"
] | [
"E3_ubiq-protein_ligase_RNF138"
] | [
953
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-983168",
"R-HSA-983168",
"R-MMU-983168",
"R-RNO-983168"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-983168"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
953
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
9
] | 3 | true | Family | E3 ubiquitin-protein ligase RNF138 | E3 ubiquitin-protein ligase RNF138 | E3_ubiq-protein_ligase_RNF138 | 9 |
IPR052499 | 52,499 | Caenorhabditis elegans Nuclear Hormone Receptors | C.elegans_NHRs | Family | 999 | true | false | The nuclear hormone receptor family in Caenorhabditis elegans includes orphan nuclear receptors that are implicated in various metabolic and physiological processes. While the specific functions of some members are not well characterized, at least one member, nhr-62, is known to play a role in the metabolic and physiol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47630"
] | [
"C.elegans_NHRs"
] | [
999
] | 1 | [
"REACTOME"
] | [
"R-CEL-383280"
] | [
"REACTOME:R-CEL-383280"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
999
] | 1 | [
"Caenorhabditis elegans"
] | [
35
] | 1 | true | Family | Caenorhabditis elegans Nuclear Hormone Receptors | Caenorhabditis elegans Nuclear Hormone Receptors | C.elegans_NHRs | 1 |
IPR052500 | 52,500 | Chloroplastic/Mitochondrial RNA Processing | Chloro/Mito_RNA_Process | Family | 935 | true | false | This family of proteins includes both chloroplastic pentatricopeptide repeat-containing proteins and mitochondrial intron-encoded endonucleases. The chloroplastic members are involved in the splicing of group II introns, which is essential for the assembly of photosystems I and II, and the proper functioning of the chl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47539"
] | [
"Chloro/Mito_RNA_Process"
] | [
935
] | 1 | [] | [] | [] | 0 | [
"1r7m",
"3c0w",
"3c0x",
"3ool",
"3oor",
"5a0m",
"6x1j"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
75,
860
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
4,
1,
1,
4
] | 4 | true | Family | Chloroplastic/Mitochondrial RNA Processing | Chloroplastic/Mitochondrial RNA Processing | Chloro/Mito_RNA_Process | 3 |
IPR052502 | 52,502 | FAM241 domain-containing protein | FAM241_domain | Family | 875 | true | false | This family of proteins may be involved in maintaining lysosome homeostasis, which is crucial for cellular waste processing and recycling of biomolecules. The exact molecular functions and biological processes associated with this family remain to be fully characterized. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33690"
] | [
"FAM241_domain"
] | [
875
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
875
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
7,
6
] | 4 | true | Family | FAM241 domain-containing protein | FAM241 domain-containing protein | FAM241_domain | 7 |
IPR052503 | 52,503 | S100-fused Epidermal Structural Protein | S100-fused_Epidermal_Struct | Family | 721 | true | false | This family of proteins is involved in the structural integrity and mechanical strength of the epidermis, particularly in the formation of the stratum corneum. Members play a crucial role in cell-cell adhesion within the cornified cell layers and contribute to the assembly of the epidermal cornified cell envelopes. The... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22571"
] | [
"S100-fused_Epidermal_Struct"
] | [
721
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-HSA-6809371",
"R-HSA-9725554",
"R-MMU-6798695"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-9725554",
"REACTOME:R-MMU-6798695"
] | 4 | [
"4pcw"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Halarcobacter mediterraneus"
] | [
720,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
13,
5
] | 3 | true | Family | S100-fused Epidermal Structural Protein | S100-fused Epidermal Structural Protein | S100-fused_Epidermal_Struct | 8 |
IPR052504 | 52,504 | Mucin-related_signaling_and_protection_protein | Mucin_signaling_protection | Family | 170 | true | false | This family of proteins includes mucins and transcription-associated components. Mucins are high molecular weight glycoproteins that form a protective, lubricating barrier on mucosal surfaces, playing a role in defense against pathogens and particles. They are involved in various cellular processes such as ligand bindi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24041"
] | [
"Mucin_signaling_protection"
] | [
170
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-913709",
"R-HSA-5083625",
"R-HSA-5083632",
"R-HSA-5083636",
"R-HSA-5621480",
"R-HSA-913709",
"R-HSA-977068"
] | [
"REACTOME:R-DDI-913709",
"REACTOME:R-HSA-5083625",
"REACTOME:R-HSA-5083632",
"REACTOME:R-HSA-5083636",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-913709",
"REACTOME:R-HSA-977068"
] | 7 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)"
] | [
9,
160,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens"
] | [
6,
1,
14
] | 3 | true | Family | Mucin-related_signaling_and_protection_protein | Mucin-related_signaling_and_protection_protein | Mucin_signaling_protection | 6 |
IPR052505 | 52,505 | Fungal Pathogen Heme-Binding RBT5 | Fungal_Heme-Binding_RBT5 | Family | 81 | true | false | The RBT5 family comprises heme-binding proteins with a role in heme-iron utilization, a critical process for the virulence of pathogenic fungi. Members of the RBT5 family are characterized by the presence of a CFEM domain, which is distinguished by its novel helical-basket fold, composed of six alpha-helices and eight ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35607"
] | [
"Fungal_Heme-Binding_RBT5"
] | [
81
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
5,
76
] | 2 | [] | [] | 0 | true | Family | Fungal Pathogen Heme-Binding RBT5 | Fungal Pathogen Heme-Binding RBT5 | Fungal_Heme-Binding_RBT5 | 7 |
IPR052506 | 52,506 | Bacterial Fibronectin-Binding | Bact_Fn-Binding | Family | 223 | true | false | This family of proteins is involved in bacterial adhesion and invasion processes. They facilitate the attachment of bacteria to various host substrates, including fibronectin, fibrinogen, elastin peptides, and tropoelastin. These interactions enable the bacteria to invade endothelial cells and adhere to activated plate... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48234"
] | [
"Bact_Fn-Binding"
] | [
223
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
116,
106,
1
] | 3 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
2,
2
] | 2 | true | Family | Bacterial Fibronectin-Binding | Bacterial Fibronectin-Binding | Bact_Fn-Binding | 5 |
IPR052507 | 52,507 | BPI fold-containing antibacterial protein | BPI_fold-antibacterial | Family | 281 | true | false | This family of proteins exhibits antibacterial activity, particularly against Pseudomonas aeruginosa. Members of this family are part of the BPI/LBP/Plunc superfamily and are characterized by the presence of a BPI fold. The BPI fold is known to play a role in binding to and neutralizing lipopolysaccharides, which are c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47145"
] | [
"BPI_fold-antibacterial"
] | [
281
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803157",
"R-MMU-6803157",
"R-RNO-6803157"
] | [
"REACTOME:R-HSA-6803157",
"REACTOME:R-MMU-6803157",
"REACTOME:R-RNO-6803157"
] | 3 | [
"5wd6",
"6o1t"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
281
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
4
] | 3 | true | Family | BPI fold-containing antibacterial protein | BPI fold-containing antibacterial protein | BPI_fold-antibacterial | 4 |
IPR052508 | 52,508 | Maize Seed Storage Zein | Maize_Zein_Storage | Family | 230 | true | false | The Zein family comprises proteins that serve as major seed storage proteins. These proteins are predominantly found in maize and related cereal grains. They are synthesized during seed development and are deposited in protein bodies within the endosperm of the seed. The primary role of zein proteins is to serve as a n... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48244"
] | [
"Maize_Zein_Storage"
] | [
230
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
230
] | 1 | [
"Zea mays"
] | [
86
] | 1 | true | Family | Maize Seed Storage Zein | Maize Seed Storage Zein | Maize_Zein_Storage | 1 |
IPR052509 | 52,509 | Metal-responsive DNA-binding regulator | Metal_resp_DNA-bind_regulator | Family | 38,803 | true | true | This entry represents Putative DNA-binding protein YizB, Transcriptional regulator Rv3488, Uncharacterized protein X. These proteins are DNA-binding proteins that are potentially involved in transcription regulation and may play a role in metal detoxification. Members of this family are known to bind to promoter region... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33169"
] | [
"Metal_resp_DNA-bind_regulator"
] | [
38803
] | 1 | [] | [] | [] | 0 | [
"1xma",
"2e1n",
"2esh",
"2zfw",
"3f8b",
"3f8c",
"3f8f",
"3hhh",
"3l7w",
"4ejo",
"4esb",
"4esf",
"4zzd",
"5dym",
"5h20",
"5zhc",
"5zhv",
"5zi8",
"5zqh",
"6abq",
"6abt",
"6do0",
"6fuu",
"6i8n",
"6r1l",
"6vwe",
"7q34",
"7qz5",
"7qz6",
"7qz7",
"7qz8",
"7qz9"... | 54 | [
"PUB00161741"
] | [
"30266832"
] | [
"Structural and functional characterization of the transcriptional regulator Rv3488 of <i>Mycobacterium tuberculosis</i> H37Rv."
] | [
2018
] | 1 | [] | [
"IPR017799"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
418,
38046,
8,
3,
328
] | 5 | [] | [] | 0 | true | Family | Metal-responsive DNA-binding regulator | Metal-responsive DNA-binding regulator | Metal_resp_DNA-bind_regulator | 3 |
IPR052511 | 52,511 | ATP-dependent Helicase | ATP-dep_Helicase | Family | 20,137 | true | false | This family of proteins includes ATP-dependent helicases which are enzymes that utilize the energy derived from ATP hydrolysis to unwind double-stranded nucleic acids. Helicases are essential for many cellular processes, including DNA replication, repair, recombination, and transcription, as well as RNA processing and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47962"
] | [
"ATP-dep_Helicase"
] | [
20137
] | 1 | [
"EC",
"EC"
] | [
"5.6.2.-",
"5.6.2.4"
] | [
"EC:5.6.2.-",
"EC:5.6.2.4"
] | 2 | [
"5v9x",
"7lhl"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1810,
17855,
44,
166,
262
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ATP-dependent Helicase | ATP-dependent Helicase | ATP-dep_Helicase | 6 |
IPR052512 | 52,512 | 4-carboxymuconolactone decarboxylase/NDH-1 regulator | 4CMD/NDH-1_regulator | Family | 23,790 | true | false | This family of proteins includes enzymes known as 4-carboxymuconolactone decarboxylases, which are involved in the beta-ketoadipate pathway, a route for the degradation of aromatic compounds. These enzymes catalyze the decarboxylation step, converting 4-carboxymuconolactone to 3-oxoadipate, a key intermediate in the pa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33570"
] | [
"4CMD/NDH-1_regulator"
] | [
23790
] | 1 | [] | [] | [] | 0 | [
"2af7",
"4g9q"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
126,
22234,
1267,
163
] | 4 | [] | [] | 0 | true | Family | 4-carboxymuconolactone decarboxylase/NDH-1 regulator | 4-carboxymuconolactone decarboxylase/NDH-1 regulator | 4CMD/NDH-1_regulator | 8 |
IPR052514 | 52,514 | S-adenosyl-L-methionine-dependent methyltransferase | SAM-dependent_MTase | Family | 16,609 | true | false | This family of proteins includes S-adenosyl-L-methionine-dependent methyltransferases involved in diverse biosynthetic pathways. Members are responsible for the methylation of various substrates, contributing to the biosynthesis of complex molecules with antibiotic, immunosuppressant, or other bioactive properties. The... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34203"
] | [
"SAM-dependent_MTase"
] | [
16609
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 146 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
691,
12213,
3177,
71,
457
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
6
] | 3 | true | Family | S-adenosyl-L-methionine-dependent methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase | SAM-dependent_MTase | 6 |
IPR052516 | 52,516 | Nicotinate and N-heterocyclic Hydroxylase | N-heterocyclic_Hydroxylase | Family | 15,398 | true | false | This family of proteins includes enzymes involved in the hydroxylation of nicotinate and other N-heterocyclic substrates. Members of this family function in the degradation pathways of nicotinate and isoquinoline, catalyzing the conversion of nicotinate to 6-hydroxynicotinate, as well as hydroxylating various N-contain... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47495"
] | [
"N-heterocyclic_Hydroxylase"
] | [
15398
] | 1 | [] | [] | [] | 0 | [
"8gy3"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
21,
14967,
37,
373
] | 4 | [] | [] | 0 | true | Family | Nicotinate and N-heterocyclic Hydroxylase | Nicotinate and N-heterocyclic Hydroxylase | N-heterocyclic_Hydroxylase | 5 |
IPR052517 | 52,517 | GlcG-related carbohydrate metabolism protein | GlcG_carb_metab_protein | Family | 16,180 | true | false | This family of proteins is involved in carbohydrate metabolism and transport. Members of the GlcG family are typically associated with the utilization of glucose and may play roles in the regulation of glucose levels within the cell. They may be involved in various biochemical pathways that process glucose or glucose-d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34309"
] | [
"GlcG_carb_metab_protein"
] | [
16180
] | 1 | [] | [] | [] | 0 | [
"2a2l",
"3fpv",
"3fpw",
"4bmw",
"4nkp",
"5cx7",
"6bws",
"6c0z",
"9jth"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pithovirus LCPAC202",
"Sym plasmid",
"unclassified sequences"
] | [
184,
15096,
753,
1,
1,
145
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | GlcG-related carbohydrate metabolism protein | GlcG-related carbohydrate metabolism protein | GlcG_carb_metab_protein | 7 |
IPR052518 | 52,518 | Chromate transport protein | CHR_Transporter | Family | 15,273 | true | true | This family of proteins is involved in the transport of chromate ions across cellular membranes. Members of this family are characterized by their similarity to the chromate ion transporter (CHR) family, which is classified under the Transporter Classification (TC) system as 2.A.51. These transporters play a role in re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43663"
] | [
"CHR_Transporter"
] | [
15273
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
28,
14936,
140,
169
] | 4 | [] | [] | 0 | true | Family | Chromate transport protein | Chromate transport protein | CHR_Transporter | 6 |
IPR052519 | 52,519 | Eukaryotic-type N-acetylglucosamine Kinase | Euk-type_GlcNAc_Kinase | Family | 15,426 | true | false | This family of proteins includes enzymes that phosphorylate various substrates, including amino sugars and sugar derivatives, using ATP. Members of this family are involved in metabolic pathways that process carbohydrates and are characterized by their kinase activity. They can phosphorylate N-acetylglucosamine (GlcNAc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43190"
] | [
"Euk-type_GlcNAc_Kinase"
] | [
15426
] | 1 | [] | [] | [] | 0 | [
"1zbs",
"1zc6",
"1zxo",
"2e2n",
"2e2o",
"2e2p",
"2e2q",
"8oqk",
"8oqw",
"8oqx",
"8ow7",
"8ow9",
"8zo3",
"8zov",
"8zpo"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
137,
13586,
1523,
180
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
5,
13
] | 3 | true | Family | Eukaryotic-type N-acetylglucosamine Kinase | Eukaryotic-type N-acetylglucosamine Kinase | Euk-type_GlcNAc_Kinase | 6 |
IPR052520 | 52,520 | Alkyltransferase-like DNA repair | ATL_DNA_repair | Family | 14,436 | true | false | The ATL subfamily of the MGMT family is involved in the recognition and repair of DNA damage. Members of this family bind to DNA containing O(6)-alkylguanine adducts, with a preference for larger alkyl groups. They facilitate the repair process by flipping the damaged base out of the DNA helix into an extrahelical posi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42942"
] | [
"ATL_DNA_repair"
] | [
14436
] | 1 | [] | [] | [] | 0 | [
"2kif",
"2kim",
"3gva",
"3gx4",
"3gyh",
"4enj",
"4enk",
"4enm",
"4enn",
"4hdu",
"4hdv"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
9,
13017,
1305,
105
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Alkyltransferase-like DNA repair | Alkyltransferase-like DNA repair | ATL_DNA_repair | 2 |
IPR052521 | 52,521 | Bacterial cell division SPOR domain-containing protein | Cell_div_SPOR-domain | Family | 12,899 | true | false | This family of proteins is involved in bacterial cell division. Members of this family are associated with the septal ring structure and are implicated in septal peptidoglycan synthesis and cell constriction. They may interact with other cell division proteins to facilitate the division process. Some proteins in this f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38687"
] | [
"Cell_div_SPOR-domain"
] | [
12899
] | 1 | [] | [] | [] | 0 | [
"1uta",
"6ztg"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanogaster sp.",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
12721,
1,
5,
2,
170
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Bacterial cell division SPOR domain-containing protein | Bacterial cell division SPOR domain-containing protein | Cell_div_SPOR-domain | 9 |
IPR052522 | 52,522 | ABC-2 integral membrane transport permease | ABC-2_transport_permease | Family | 12,620 | true | false | This family of proteins is involved in the transport of various molecules across the inner membranes of bacterial cells. They are part of the ATP-binding cassette (ABC) transporter superfamily, specifically the ABC-2 integral membrane group. These proteins typically function as permeases, which are components of larger... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43332"
] | [
"ABC-2_transport_permease"
] | [
12620
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
265,
12117,
16,
222
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | ABC-2 integral membrane transport permease | ABC-2 integral membrane transport permease | ABC-2_transport_permease | 5 |
IPR052523 | 52,523 | Trichothecene Biosynthesis Acetyltransferases | Trichothecene_AcTrans | Family | 21,463 | true | false | The acetyltransferase family is involved in various biological processes, including the biosynthesis of secondary metabolites such as satratoxins, which are trichothecene mycotoxins linked to human food poisonings. Members of the family function as acetyltransferases, which are enzymes that transfer acetyl groups to su... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42791"
] | [
"Trichothecene_AcTrans"
] | [
21463
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"2qec",
"3mgd",
"7k09",
"7k0a"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Heunggongvirae",
"metagenomes"
] | [
27,
6060,
15281,
2,
93
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
7,
2
] | 2 | true | Family | Trichothecene Biosynthesis Acetyltransferases | Trichothecene Biosynthesis Acetyltransferases | Trichothecene_AcTrans | 5 |
IPR052524 | 52,524 | Major Facilitator Superfamily Cyanate Porter | MFS_Cyanate_Porter | Family | 16,700 | true | false | This family of proteins is part of the major facilitator superfamily and is involved in the active transport of specific substrates across cellular membranes. Members of this family function as transporters for various compounds, including cyanate and anionic 4-hydroxy-benzoate, and are also implicated in the efflux of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23523"
] | [
"MFS_Cyanate_Porter"
] | [
16700
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
16463,
12,
94,
131
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Major Facilitator Superfamily Cyanate Porter | Major Facilitator Superfamily Cyanate Porter | MFS_Cyanate_Porter | 8 |
IPR052526 | 52,526 | HTH-type transcriptional regulators in bedaquiline tolerance | HTH-type_Bedaq_tolerance | Family | 13,902 | true | false | The HTH-type transcriptional regulator family is involved in a regulatory network that coordinates bacterial tolerance to the antitubercular drug bedaquiline. Members of the family are characterized by the presence of a winged helix-turn-helix (HTH) domain, which is typically involved in DNA binding and regulation of g... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39515"
] | [
"HTH-type_Bedaq_tolerance"
] | [
13902
] | 1 | [] | [] | [] | 0 | [
"2hr3",
"4yif"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Russula earlei",
"Sym plasmid",
"metagenomes"
] | [
13853,
1,
1,
47
] | 4 | [] | [] | 0 | true | Family | HTH-type transcriptional regulators in bedaquiline tolerance | HTH-type transcriptional regulators in bedaquiline tolerance | HTH-type_Bedaq_tolerance | 5 |
IPR052527 | 52,527 | Heavy metal cation-efflux system component | Metal_cation-efflux_comp | Family | 8,836 | true | false | This family of proteins includes components of cation-efflux systems that confer resistance to various heavy metals such as cobalt, zinc, cadmium, and nickel. Members of this family appear to be involved in the specificity and transport of these metals, contributing to the detoxification and resistance mechanisms in ba... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43847"
] | [
"Metal_cation-efflux_comp"
] | [
8836
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Fadolivirus FV1/VV64",
"unclassified sequences"
] | [
192,
7775,
668,
1,
200
] | 5 | [] | [] | 0 | true | Family | Heavy metal cation-efflux system component | Heavy metal cation-efflux system component | Metal_cation-efflux_comp | 3 |
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