LiteFold/InterPro · Datasets at Hugging Face

IPR052528

52,528

Putative sugar transporter and related proteins

Sugar_transport-like

Family

8,642

true

false

This family of proteins includes uncharacterized members and a characterized ribitol transporter. The ribitol transporter is part of the major facilitator superfamily, which is known for transporting sugars across membranes. The similarity to E. coli YihN suggests a potential function related to nucleotide sugar metabo...

[]

0

[ "PANTHER" ]

[ "PTHR23526" ]

[ "Sugar_transport-like" ]

[ 8642 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 404, 8063, 12, 163 ]

4

[]

0

true

Family

Putative sugar transporter and related proteins

Sugar_transport-like

8

IPR052530

52,530

NAD(P)H nitroreductase

NAD(P)H_nitroreductase

Family

12,500

true

false

This family of proteins is involved in the reduction of nitroaromatic compounds. Members of this family are typically characterized by their ability to utilize NAD(P)H as an electron donor to convert nitro groups to amino groups through a reductive process. This biochemical activity is important for the detoxification ...

[]

0

[ "PANTHER" ]

[ "PTHR43821" ]

[ "NAD(P)H_nitroreductase" ]

[ 12500 ]

1

[]

0

[ "2i7h", "3bm1", "3bm2", "3k6h", "7tmf", "7tmg", "8dil" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12103, 281, 116 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NAD(P)H nitroreductase

NAD(P)H_nitroreductase

7

IPR052531

52,531

CarD-like transcription regulator

CarD-like_regulator

Family

10,476

true

false

This family of proteins includes transcription factors that interact with RNA polymerase to control ribosomal RNA transcription. Members are involved in the regulation of replication and persistence during infection in some species. They also play a role in the response to various stresses, including starvation, oxidat...

[]

0

[ "PANTHER" ]

[ "PTHR38447" ]

[ "CarD-like_regulator" ]

[ 10476 ]

1

[]

0

[ "2lqk", "2lt1", "2lt3", "2lt4", "2lwj", "4ilu", "4kbm", "4kmc", "4l5g", "4mfr", "4xax", "4xlr", "4xls", "6edt", "6ee8", "6eec", "6vvx", "6vvy", "6vvz", "6vw0", "7kif", "7kim", "7kin", "8hvr", "8jke", "9e7v", "9e7y", "9e84", "9e85", "9e86", "9e87", "9e88"...

32

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 10222, 8, 246 ]

3

[]

0

true

Family

CarD-like transcription regulator

CarD-like_regulator

9

IPR052534

52,534

Extracellular DNA Utilization and Secretion System Component

Extracell_DNA_Util/SecSys_Comp

Family

9,121

true

false

This family of proteins includes components involved in the utilization of extracellular DNA as a nutrient and the assembly and function of secretion systems. Members are implicated in various cellular processes such as adhesion, colonization, biofilm maturation, and virulence. They play roles in the inner membrane, fo...

[]

0

[ "PANTHER" ]

[ "PTHR40278" ]

[ "Extracell_DNA_Util/SecSys_Comp" ]

[ 9121 ]

1

[]

0

[ "3jc8", "3jc9" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "environmental samples", "unclassified sequences" ]

[ 8991, 8, 2, 120 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Extracellular DNA Utilization and Secretion System Component

Extracell_DNA_Util/SecSys_Comp

4

IPR052535

52,535

Bacilysin biosynthesis H2HPP isomerase

Bacilysin_H2HPP_isomerase

Family

8,583

true

false

This family of proteins is involved in the biosynthesis of bacilysin, a nonribosomally synthesized dipeptide antibiotic composed of L-alanine and L-anticapsin. Members of this family function as isomerases, specifically catalyzing the allylic isomerization of endocyclic-delta(4),delta(8)-7R-dihydro-hydroxyphenylpyruvat...

[]

0

[ "PANTHER" ]

[ "PTHR40112" ]

[ "Bacilysin_H2HPP_isomerase" ]

[ 8583 ]

1

[ "EC", "METACYC" ]

[ "5.3.3.19", "PWY-7626" ]

[ "EC:5.3.3.19", "METACYC:PWY-7626" ]

2

[ "2pfw", "3h7j", "3h7y", "3h9a", "4e2g", "5fpx", "5fpz", "5fq0", "5zbe", "5zbf", "7zyb", "7zyc", "9bwf", "9bwh", "9bwi" ]

15

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 513, 7645, 248, 177 ]

4

[]

0

true

Family

Bacilysin biosynthesis H2HPP isomerase

Bacilysin_H2HPP_isomerase

6

IPR052536

52,536

ABC-4 Integral Membrane

ABC-4_Integral_Memb_Prot

Family

12,349

true

false

The ABC-4 integral membrane protein family is involved in the transport of specific substrates across the cell membrane, functioning as part of ABC transporter complexes. Members of the family such as BceAB and YxdLM are implicated in the export of bacitracin and possibly in peptide resistance, respectively. These tran...

[]

0

[ "PANTHER" ]

[ "PTHR46795" ]

[ "ABC-4_Integral_Memb_Prot" ]

[ 12349 ]

1

[]

0

[ "7tcg", "7tch", "8g3a", "8g3b", "8g3f", "8g3l", "8g4c", "8g4d", "8s5g" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12282, 2, 65 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

ABC-4 Integral Membrane

ABC-4_Integral_Memb_Prot

3

IPR052537

52,537

Extradiol ring-cleavage dioxygenase

Extradiol_RC_dioxygenase

Family

10,962

true

false

This family of proteins includes extradiol ring-cleavage dioxygenases that are involved in the degradation of aromatic compounds with two hydroxyl groups at para positions. These enzymes catalyze the oxidative cleavage of aromatic rings, a critical step in the breakdown of various pollutants and toxins, such as gamma-h...

[]

0

[ "PANTHER" ]

[ "PTHR36110" ]

[ "Extradiol_RC_dioxygenase" ]

[ 10962 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.13.11.-", "PWY-181", "PWY-5163", "PWY-5642", "PWY-6068", "PWY-6069", "PWY-6084", "PWY-6087", "PWY-6089", "PWY-6093", "PWY-6094", "PWY-6102", "PWY-6107", "PWY-6178", "PWY-6190", "PWY-6193", "PWY-6336", "PWY-6339", "PWY-6667", "PWY-7006", "PWY-7009", "PWY-7010", "PWY-701...

[ "EC:1.13.11.-", "METACYC:PWY-181", "METACYC:PWY-5163", "METACYC:PWY-5642", "METACYC:PWY-6068", "METACYC:PWY-6069", "METACYC:PWY-6084", "METACYC:PWY-6087", "METACYC:PWY-6089", "METACYC:PWY-6093", "METACYC:PWY-6094", "METACYC:PWY-6102", "METACYC:PWY-6107", "METACYC:PWY-6178", "METACYC:PWY-...

38

[ "1zsw", "3oaj", "4huz" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 738, 10170, 7, 47 ]

4

[]

0

true

Family

Extradiol ring-cleavage dioxygenase

Extradiol_RC_dioxygenase

7

IPR052538

52,538

Flavonoid dioxygenase-like

Flavonoid_dioxygenase-like

Family

8,510

true

false

This family of proteins includes enzymes that are involved in the degradation of flavonoids, specifically catalyzing the dioxygenolytic cleavage of the O-heteroaromatic ring of flavonols. The enzymatic reaction results in the breakdown of compounds such as quercetin into smaller molecules, which is a key step in the ca...

[]

0

[ "PANTHER" ]

[ "PTHR43346" ]

[ "Flavonoid_dioxygenase-like" ]

[ 8510 ]

1

[]

0

[ "1gqg", "1gqh", "1h1i", "1h1m", "1juh", "2oa2", "7zvm", "7zvy" ]

8

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 187, 7049, 1157, 41, 76 ]

5

[]

0

true

Family

Flavonoid dioxygenase-like

Flavonoid_dioxygenase-like

1

IPR052539

52,539

Molybdopterin-guanine dinucleotide biosynthesis adapter

MGD_biosynthesis_adapter

Family

8,466

true

false

This family of proteins includes GTP-binding proteins that are involved in the biosynthesis and utilization of the molybdenum cofactor, specifically the Mo-molybdopterin guanine dinucleotide (Mo-MGD) form. Although they are not essential for the formation of Mo-MGD or for the activation of molybdoenzymes that utilize t...

[]

0

[ "PANTHER" ]

[ "PTHR40072" ]

[ "MGD_biosynthesis_adapter" ]

[ 8466 ]

1

[]

0

[ "1np6", "1p9n", "1xjc", "2f1r", "4nkr", "4oyh" ]

6

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 500, 7805, 8, 153 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Molybdopterin-guanine dinucleotide biosynthesis adapter

MGD_biosynthesis_adapter

6

IPR052541

52,541

Sulfide-quinone oxidoreductase

SQRD

Family

6,152

true

false

This family of proteins includes enzymes that are involved in the oxidation of sulfides, such as hydrogen sulfide, using quinones as electron acceptors. The reaction catalyzed by these enzymes leads to the formation of polysulfide products at the active site cysteine residues. These products are released when they reac...

[]

0

[ "PANTHER" ]

[ "PTHR43755" ]

[ "SQRD" ]

[ 6152 ]

1

[]

0

[ "1fcd", "3h8i", "3h8l", "3vrd", "5n1t" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 726, 5155, 35, 236 ]

4

[]

0

true

Family

Sulfide-quinone oxidoreductase

SQRD

3

IPR052542

52,542

Cholesterol Oxidase Enzyme

Cholesterol_Oxidase

Family

10,462

true

false

The Cholesterol Oxidase family comprises enzymes that play a crucial role in the cholesterol degradation pathway. Members of this family are responsible for the oxidation and isomerization of cholesterol to cholestenone, which is a key initial step in breaking down cholesterol. These enzymes are characterized by their ...

[]

0

[ "PANTHER" ]

[ "PTHR47470" ]

[ "Cholesterol_Oxidase" ]

[ 10462 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.3.6", "5.3.3.1", "PWY-2582", "PWY-6945", "PWY-6946", "PWY-6948", "PWY-699", "PWY-7299", "PWY-8151", "PWY-8200", "PWY-8202" ]

[ "EC:1.1.3.6", "EC:5.3.3.1", "METACYC:PWY-2582", "METACYC:PWY-6945", "METACYC:PWY-6946", "METACYC:PWY-6948", "METACYC:PWY-699", "METACYC:PWY-7299", "METACYC:PWY-8151", "METACYC:PWY-8200", "METACYC:PWY-8202" ]

11

[ "1b4v", "1b8s", "1cbo", "1cc2", "1coy", "1ijh", "1mxt", "1n1p", "1n4u", "1n4v", "1n4w", "2gew", "3b3r", "3b6d", "3cnj", "3cox", "3gyi", "3gyj", "4rek", "4u2l", "4u2s", "4u2t", "4xwr", "4xxg", "5kwf" ]

25

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8914, 1372, 176 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Cholesterol Oxidase Enzyme

Cholesterol_Oxidase

9

IPR052543

52,543

HTH-type Metal-responsive Transcriptional Regulator

HTH_Metal-responsive_Reg

Family

9,875

true

false

This family of proteins includes helix-turn-helix (HTH) type transcriptional regulators that are responsive to metal ions. Members of this family are known to repress transcription of specific operons by binding to DNA. The presence of certain metal ions, such as cadmium or lead, can induce these proteins to release fr...

[]

0

[ "PANTHER" ]

[ "PTHR39168" ]

[ "HTH_Metal-responsive_Reg" ]

[ 9875 ]

1

[]

0

[ "2jsc" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9842, 8, 25 ]

3

[]

0

true

Family

HTH-type Metal-responsive Transcriptional Regulator

HTH_Metal-responsive_Reg

7

IPR052544

52,544

Bacteriocin Processing Enzyme

Bacteriocin_Proc_Enz

Family

6,899

true

false

The protein family includes enzymes involved in the processing of precursor peptides into their active forms. Members of the family are necessary for the maturation of bacteriocins, which are ribosomally synthesized antibacterial peptides. Specifically, the family is responsible for the conversion of inactive precursor...

[]

0

[ "PANTHER" ]

[ "PTHR43745" ]

[ "Bacteriocin_Proc_Enz" ]

[ 6899 ]

1

[]

0

[ "3hj9", "3hoi", "5lq4", "6gos", "6grg", "6grh", "6gri", "7ly4", "7ly5", "7ly6", "7ly7", "8cqs", "8pz5" ]

13

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 482, 6227, 13, 177 ]

4

[]

0

true

Family

Bacteriocin Processing Enzyme

Bacteriocin_Proc_Enz

2

IPR052546

52,546

Transposase_8_domain-containing_protein

Transposase_8_domain

Family

7,968

true

false

This family of proteins includes members that are typically associated with mobile genetic elements, specifically insertion sequences. These proteins are related to transposases, which are enzymes that catalyze the movement of DNA segments within the genome. Members of this family are likely to play a role in the recom...

[]

0

[ "PANTHER" ]

[ "PTHR33609" ]

[ "Transposase_8_domain" ]

[ 7968 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 7730, 18, 210 ]

4

[]

0

true

Family

Transposase_8_domain-containing_protein

Transposase_8_domain

8

IPR052547

52,547

Mitochondrial Isobutyryl-CoA Dehydrogenase

Mito_Isobutyryl-CoADH

Family

9,369

true

false

This family of proteins includes mitochondrial isobutyryl-CoA dehydrogenases that play a crucial role in the catabolism of valine, an essential branched-chain amino acid. Members of this family are primarily responsible for the oxidation of isobutyryl-CoA to methacrylyl-CoA, a critical step in the valine degradation pa...

[]

0

[ "PANTHER" ]

[ "PTHR43831" ]

[ "Mito_Isobutyryl-CoADH" ]

[ 9369 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.8.5", "PWY-5109", "PWY-8181", "PWY-8182", "R-BTA-70895", "R-BTA-9837999", "R-DDI-70895", "R-DDI-9837999", "R-HSA-70895", "R-HSA-9837999", "R-MMU-70895", "R-MMU-9837999" ]

[ "EC:1.3.8.5", "METACYC:PWY-5109", "METACYC:PWY-8181", "METACYC:PWY-8182", "REACTOME:R-BTA-70895", "REACTOME:R-BTA-9837999", "REACTOME:R-DDI-70895", "REACTOME:R-DDI-9837999", "REACTOME:R-HSA-70895", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-70895", "REACTOME:R-MMU-9837999" ]

12

[ "1rx0" ]

1

[]

0

[]

0

null

[ "Archaeoglobus fulgidus", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1, 7444, 1854, 70 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 9, 4, 5 ]

5

true

Family

Mitochondrial Isobutyryl-CoA Dehydrogenase

Mito_Isobutyryl-CoADH

1

IPR052548

52,548

Type VII toxin-antitoxin system antitoxin

Type_VII_TA_antitoxin

Family

5,553

true

false

This family of proteins includes probable antitoxin components of type VII toxin-antitoxin (TA) systems. Members of this family are thought to neutralize their cognate toxins through a mechanism that likely involves di-AMPylation or AMPylation. These antitoxins may bind nucleotides with varying affinities, with some sh...

[]

0

[ "PANTHER" ]

[ "PTHR33933" ]

[ "Type_VII_TA_antitoxin" ]

[ 5553 ]

1

[ "EC" ]

[ "2.7.7.108" ]

[ "EC:2.7.7.108" ]

1

[ "1no5", "2rff" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "unclassified sequences" ]

[ 762, 4639, 2, 150 ]

4

[]

0

true

Family

Type VII toxin-antitoxin system antitoxin

Type_VII_TA_antitoxin

4

IPR052549

52,549

Spore maturation protein B

SpmB

Family

7,434

true

false

The SpmB family includes proteins involved in spore core dehydration, suggesting a role in the transport of molecules into or out of the forespore, or in modifications of the cortex peptidoglycan structure during spore maturation. The family is named after Spore maturation protein B, which is a representative member. T...

[]

0

[ "PANTHER" ]

[ "PTHR35793" ]

[ "SpmB" ]

[ 7434 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7311, 2, 121 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Spore maturation protein B

SpmB

2

IPR052550

52,550

Pyrimidine 5'-nucleotidase YjjG

Pyrimidine_5'-ntase_YjjG

Family

8,753

true

false

The YjjG family proteins are nucleotidases with high phosphatase activity towards non-canonical pyrimidine nucleotides and canonical nucleoside 5'-monophosphates such as UMP, dUMP, and dTMP. They exhibit house-cleaning functions in vivo, protecting cells from incorporation of potentially mutagenic nucleotides like 5-fl...

[]

0

[ "PANTHER" ]

[ "PTHR47478" ]

[ "Pyrimidine_5'-ntase_YjjG" ]

[ 8753 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.3.5", "PWY-5381", "PWY-5695", "PWY-6596", "PWY-6606", "PWY-6607", "PWY-6608", "PWY-7185", "PWY-7821" ]

[ "EC:3.1.3.5", "METACYC:PWY-5381", "METACYC:PWY-5695", "METACYC:PWY-6596", "METACYC:PWY-6606", "METACYC:PWY-6607", "METACYC:PWY-6608", "METACYC:PWY-7185", "METACYC:PWY-7821" ]

9

[ "3ed5", "3i76", "3qnm" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Marseillevirus LCMAC202", "metagenomes" ]

[ 76, 8582, 37, 1, 57 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pyrimidine 5'-nucleotidase YjjG

Pyrimidine_5'-ntase_YjjG

1

IPR052551

52,551

UV-induced DNA damage repair photolyase

UV-DNA_repair_photolyase

Family

6,562

true

false

This family of proteins includes members involved in the repair of UV-induced DNA damage, specifically (6-4) lesions. One characterized member functions as a photolyase, utilizing blue-light energy to catalyze the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts in both single-stranded and double-stranded...

[]

0

[ "PANTHER" ]

[ "PTHR38657" ]

[ "UV-DNA_repair_photolyase" ]

[ 6562 ]

1

[]

0

[ "3zxs", "4dja", "5kcm", "5lfa", "6dd6", "7ykn", "8a1h", "8ijy", "9hnk", "9hnl", "9hnm", "9hnn", "9hno", "9q8f" ]

14

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Imitervirales", "unclassified sequences" ]

[ 232, 6078, 27, 39, 186 ]

5

[]

0

true

Family

UV-induced DNA damage repair photolyase

UV-DNA_repair_photolyase

5

IPR052552

52,552

YeaO-like

Family

8,554

false

This entry represents a subclade of DUF488 domains lacking the catalytic residues common to the rhodanese-phosphatase superfamily. The C-terminal core strand is degenerate in this subclade [ ]. Members of this family are uncharacterised proteins such as the E. coli YeaO protein and the Mycobacterium tuberculosis Rv3073...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF22752", "PTHR36849" ]

[ "DUF488-N3i", "" ]

[ 8428, 8460 ]

2

[]

0

[]

0

[ "PUB00153826" ]

[ "36968430" ]

[ "New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts." ]

[ 2023 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 176, 8326, 12, 40 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YeaO-like

9

IPR052553

52,553

Cobalt-precorrin-5A hydrolase

CbiG_hydrolase

Family

7,491

true

false

This family of proteins is involved in the biosynthesis of cobalamin (vitamin B12), where they play a crucial role by catalyzing a specific hydrolysis step. Members of this family are responsible for the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A. This reaction results in the removal of the C...

[]

0

[ "PANTHER" ]

[ "PTHR37477" ]

[ "CbiG_hydrolase" ]

[ 7491 ]

1

[ "EC", "METACYC" ]

[ "3.7.1.12", "PWY-7377" ]

[ "EC:3.7.1.12", "METACYC:PWY-7377" ]

2

[ "2w6k", "2w6l", "3by5", "3eeq" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "metagenomes" ]

[ 685, 6701, 5, 100 ]

4

[]

0

true

Family

Cobalt-precorrin-5A hydrolase

CbiG_hydrolase

3

IPR052554

52,554

2-oxoglutarate synthase subunit KorC

2-oxoglutarate_synth_KorC

Family

3,921

true

false

The 2-oxoglutarate synthase subunit KorC family includes proteins that are likely involved in the enzymatic conversion of 2-oxoglutarate to succinyl-CoA and CO2 in an ATP-dependent manner. This reaction is a key step in the Krebs cycle, an essential metabolic pathway for energy production in aerobic organisms. Members ...

[]

0

[ "PANTHER" ]

[ "PTHR42730" ]

[ "2-oxoglutarate_synth_KorC" ]

[ 3921 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.7.3", "PWY-5392", "PWY-6969", "PWY-7254" ]

[ "EC:1.2.7.3", "METACYC:PWY-5392", "METACYC:PWY-6969", "METACYC:PWY-7254" ]

4

[ "3g2e", "3on3", "8ys5", "8ys6" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "unclassified sequences" ]

[ 285, 3389, 2, 245 ]

4

[]

0

true

Family

2-oxoglutarate synthase subunit KorC

2-oxoglutarate_synth_KorC

5

IPR052555

52,555

dCTP Pyrophosphatase

dCTP_Pyrophosphatase

Family

7,421

true

false

This family of proteins is involved in the hydrolysis of deoxynucleoside triphosphates (dNTPs) into their corresponding nucleoside monophosphates, with a particular specificity for dCTP and its analogs, including modified forms such as 5-iodo-dCTP and 5-methyl-dCTP. The enzymatic activity serves a protective role, prev...

[]

0

[ "PANTHER" ]

[ "PTHR46523" ]

[ "dCTP_Pyrophosphatase" ]

[ 7421 ]

1

[ "EC", "REACTOME" ]

[ "3.6.1.12", "R-HSA-499943" ]

[ "EC:3.6.1.12", "REACTOME:R-HSA-499943" ]

2

[ "2a3q", "2oie", "2oig", "2q4p", "4qgp", "6sqw", "6sqy", "6sqz", "7mu5" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 104, 6388, 815, 2, 112 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 4 ]

4

true

Family

dCTP Pyrophosphatase

dCTP_Pyrophosphatase

2

IPR052556

52,556

Polysaccharide Synthase/Transporter

PolySynth_Transporter

Family

4,286

true

false

This family of proteins includes members that are potentially involved in the biosynthesis and transport of polysaccharides. Some proteins in this family may play a role in the translocation of nascent O-polysaccharide molecules and/or their ligation to lipid A core units, which is a critical step in the assembly of ba...

[]

0

[ "PANTHER" ]

[ "PTHR43424" ]

[ "PolySynth_Transporter" ]

[ 4286 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 167, 4060, 59 ]

3

[]

0

true

Family

Polysaccharide Synthase/Transporter

PolySynth_Transporter

1

IPR052557

52,557

Cytoskeleton-associated protease/Cytokinesis protein

CAP/Cytokinesis_protein

Family

8,046

true

false

This family of proteins includes enzymes with protease activity that are associated with the cytoskeleton and are implicated in muscle growth and neuromuscular junction maturation and stabilization. Members of this family may participate in cleaving specific muscle proteins, contributing to muscle function. Additionall...

[]

0

[ "PANTHER" ]

[ "PTHR46333" ]

[ "CAP/Cytokinesis_protein" ]

[ 8046 ]

1

[]

0

[ "9crn" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 3520, 4504, 7, 15 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2, 3, 3, 1, 1 ]

7

true

Family

Cytoskeleton-associated protease/Cytokinesis protein

CAP/Cytokinesis_protein

4

IPR052558

52,558

Siderophore Hydrolyzing Esterase D

Siderophore_Hydrolase_D

Family

8,109

true

false

The Esterase D family is involved in the hydrolysis of siderophores, which are iron-chelating compounds crucial for microbial iron uptake and virulence. Members of this family display specificity towards various siderophores, including triacetylfusarinine C, bacillibactin, and enterobactin, facilitating the release of ...

[]

0

[ "PANTHER" ]

[ "PTHR40841" ]

[ "Siderophore_Hydrolase_D" ]

[ 8109 ]

1

[]

0

[ "2gzr", "2gzs", "2qm0", "3gff", "6gi0", "6gi1", "6gi2", "6gi5", "6gud", "6gug", "6gui", "6gul", "6gun", "6guo", "6gur" ]

15

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7259, 808, 42 ]

3

[]

0

true

Family

Siderophore Hydrolyzing Esterase D

Siderophore_Hydrolase_D

2

IPR052559

52,559

Vanadium-dependent haloperoxidase

V-haloperoxidase

Family

5,850

true

false

This family of proteins includes enzymes that catalyze the halogenation of organic substrates using hydrogen peroxide. Members of this family are characterized by their ability to utilize vanadium as a cofactor in the oxidation of halides, such as chloride or bromide, to generate hypohalous acids. These acids can then ...

[]

0

[ "PANTHER" ]

[ "PTHR34599" ]

[ "V-haloperoxidase" ]

[ 5850 ]

1

[ "EC" ]

[ "1.11.1.18" ]

[ "EC:1.11.1.18" ]

1

[ "1idq", "1idu", "1qhb", "1qi9", "1up8", "1vnc", "1vne", "1vnf", "1vng", "1vnh", "1vni", "1vns", "3bb0", "3w35", "3w36", "4cit", "4usz", "5aa6", "5lpc", "7qvw", "7qw3", "7qwi", "7qyy", "8cxl", "8q20", "8q21", "8q22", "8vgx", "8vh0", "8vix", "8vjq" ]

31

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 21, 5131, 653, 14, 31 ]

5

[]

0

true

Family

Vanadium-dependent haloperoxidase

V-haloperoxidase

1

IPR052560

52,560

RNA-directed DNA polymerase, mobile element

RdDP_mobile_element

Family

7,922

true

false

This family of proteins includes RNA-directed DNA polymerases from mobile genetic elements such as transposons. These enzymes are responsible for transcribing RNA into DNA, a process central to the mechanism of retrotransposition. Retrotransposons, which are a type of mobile element, use these polymerases to replicate ...

[]

0

[ "PANTHER" ]

[ "PTHR36688" ]

[ "RdDP_mobile_element" ]

[ 7922 ]

1

[ "EC" ]

[ "2.7.7.49" ]

[ "EC:2.7.7.49" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Trachysalambria curvirostris nimavirus", "invertebrate metagenome" ]

[ 3, 7914, 1, 4 ]

4

[ "Drosophila melanogaster" ]

[ 22 ]

1

true

Family

RNA-directed DNA polymerase, mobile element

RdDP_mobile_element

9

IPR052561

52,561

Complex I Subunit 1

ComplexI_Subunit1

Family

5,000

true

false

The Complex I Subunit 1 family is involved in the electron transport chain, a crucial step in cellular respiration. Members of this family are typically part of larger enzyme complexes such as NADH-ubiquinone oxidoreductase (Complex I) and formate hydrogenlyase, which are responsible for the transfer of electrons from ...

[]

0

[ "PANTHER" ]

[ "PTHR43359" ]

[ "ComplexI_Subunit1" ]

[ 5000 ]

1

[]

0

[ "6cfw", "6u8y", "7z0s", "7z0t" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 683, 4150, 167 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Complex I Subunit 1

ComplexI_Subunit1

4

IPR052562

52,562

Ketohexokinase-related

Family

8,043

true

false

This family of proteins is involved in the metabolism of carbohydrates, specifically in the phosphorylation of fructose to produce fructose-1-phosphate. The enzymatic activity is essential for the utilisation of fructose as a source of energy and carbon skeletons. Members of this family require potassium for their acti...

[]

0

[ "PANTHER" ]

[ "PTHR42774" ]

[ "Ketohexokinase-related" ]

[ 8043 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.3", "PWY-8404", "R-HSA-5657562", "R-HSA-70350", "R-MMU-70350", "R-RNO-70350" ]

[ "EC:2.7.1.3", "METACYC:PWY-8404", "REACTOME:R-HSA-5657562", "REACTOME:R-HSA-70350", "REACTOME:R-MMU-70350", "REACTOME:R-RNO-70350" ]

6

[ "2hlz", "2hqq", "2hw1", "3b3l", "3nbv", "3nbw", "3nc2", "3nc9", "3nca", "3q92", "3qa2", "3qai", "3ro4", "5wbm", "5wbo", "5wbp", "5wbq", "5wbr", "5wbz", "6p2d", "6ul7", "6w0n", "6w0w", "6w0x", "6w0y", "6w0z", "8omd", "8ome", "8omf", "8omg", "8omj", "8omk"...

37

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 3, 3446, 4531, 63 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 5, 7, 4, 6, 2, 9, 7, 11 ]

9

true

Family

Ketohexokinase-related

3

IPR052565

52,565

Glutaredoxin-like YDR286C

Glutaredoxin-like_YDR286C

Family

6,408

true

false

This family of proteins is characterized by a conserved domain that suggests a role in redox reactions, specifically through the catalysis of thiol-disulfide exchange reactions which are fundamental to cellular redox homeostasis. Members of this family are likely to function in the reduction of protein disulfides and i...

[]

0

[ "PANTHER" ]

[ "PTHR33558" ]

[ "Glutaredoxin-like_YDR286C" ]

[ 6408 ]

1

[]

0

[ "1wjk", "2fgx" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 3395, 2923, 7, 83 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 1, 2, 5, 1, 1, 3, 5, 1, 4 ]

10

true

Family

Glutaredoxin-like YDR286C

Glutaredoxin-like_YDR286C

4

IPR052568

52,568

Polyketide Synthase and Fatty Acid Synthase

PKS-FAS_Synthase

Family

3,591

true

false

The protein family is involved in the biosynthesis of various polyketide-derived compounds, including pigments and polyunsaturated fatty acids (PUFAs). One member catalyzes the formation of a yellow pigment in conidia by condensing acetate units into a heptaketide naphthopyrene. Another is implicated in the production ...

[]

0

[ "PANTHER" ]

[ "PTHR43074" ]

[ "PKS-FAS_Synthase" ]

[ 3591 ]

1

[]

0

[ "6riw" ]

1

[]

0

[]

0

null

[ "Bacteria", "Candidatus Heimdallarchaeum aukensis", "Eukaryota", "unclassified sequences" ]

[ 3235, 1, 90, 265 ]

4

[]

0

true

Family

Polyketide Synthase and Fatty Acid Synthase

PKS-FAS_Synthase

5

IPR052570

52,570

Flagellar FliJ

FliJ

Family

5,042

true

false

This family of proteins is involved in the structure and function of bacterial flagella, which are essential for motility and chemotaxis. Members of this family play a role in the assembly and operation of the flagellar apparatus, influencing the bacterial cell's ability to move towards or away from chemical stimuli. M...

[]

0

[ "PANTHER" ]

[ "PTHR38786" ]

[ "FliJ" ]

[ 5042 ]

1

[]

0

[ "3ajw", "8ftw", "8ftx" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4987, 6, 49 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar FliJ

FliJ

1

IPR052571

52,571

Mitochondrial RNA Methyltransferase

Mt_RNA_Methyltransferase

Family

6,044

true

false

This family of proteins includes mitochondrial S-adenosyl-L-methionine-dependent RNA methyltransferases, which are likely involved in the methylation of mitochondrial rRNA. This modification is essential for the stabilization of the mitochondrial small ribosomal subunit (mt-SSU), a critical component for the assembly a...

[]

0

[ "PANTHER" ]

[ "PTHR13184" ]

[ "Mt_RNA_Methyltransferase" ]

[ 6044 ]

1

[]

0

[ "6sg9", "6sga", "6sgb", "8csp", "8csq", "8csr", "8css", "8cst", "8csu", "8d8j", "8d8k", "8d8l", "8om2", "9hny" ]

14

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "ecological metagenomes" ]

[ 1838, 4188, 12, 6 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 3, 1, 6, 4, 1, 4, 1, 1, 5 ]

11

true

Family

Mitochondrial RNA Methyltransferase

Mt_RNA_Methyltransferase

2

IPR052572

52,572

UPF0153 domain-containing protein

UPF0153_domain

Family

4,652

true

false

This family of proteins is characterized by the UPF0153 domain. The specific functions of these proteins are not well characterized. However, proteins with the UPF0153 domain are typically small and conserved across various bacterial species, suggesting a fundamental role in bacterial physiology. The domain's function ...

[]

0

[ "PANTHER" ]

[ "PTHR36931" ]

[ "UPF0153_domain" ]

[ 4652 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Burkholderia phage vB_BpP_HN02", "Eukaryota", "unclassified sequences" ]

[ 4627, 1, 2, 22 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

UPF0153 domain-containing protein

UPF0153_domain

8

IPR052573

52,573

DnaJ homolog subfamily C member 28

DnaJ_C_subfamily_28

Family

4,890

true

false

The DnaJ homolog subfamily C member 28 family includes proteins that are potentially involved in protein folding or may function as chaperones. These proteins are likely to assist in the correct folding of other proteins or in the stabilization of unfolded or partially folded proteins, preventing their aggregation. The...

[]

0

[ "PANTHER" ]

[ "PTHR39158" ]

[ "DnaJ_C_subfamily_28" ]

[ 4890 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3022, 1856, 12 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 3, 1, 1, 4, 3, 2, 2 ]

9

true

Family

DnaJ homolog subfamily C member 28

DnaJ_C_subfamily_28

2

IPR052575

52,575

Small subunit processome component 20

SSU_processome_comp_20

Family

6,357

true

false

This family of proteins is involved in the early stages of ribosome assembly, particularly in the processing of pre-18S ribosomal RNA within the nucleolus. Members of this family are components of the small subunit (SSU) processome and associate with U3 small nucleolar RNA (snoRNA). They contribute to the folding, modi...

[]

0

[ "PANTHER" ]

[ "PTHR17695" ]

[ "SSU_processome_comp_20" ]

[ 6357 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

5

[ "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6rxu", "6rxv", "6rxx", "6rxz", "6zqb", "6zqc", "6zqd", "6zqe", "7ajt", "7aju", "7d4i", "7d5t", "7d63", "7mq8", "7mq9", "7mqa", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z", "9n70"...

41

[]

0

[]

0

null

[ "Eukaryota", "Streptomyces actuosus" ]

[ 6356, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 3, 2, 2, 6, 1, 2, 2, 1, 1, 51 ]

12

true

Family

Small subunit processome component 20

SSU_processome_comp_20

6

IPR052576

52,576

Amino Acid Transporter-Related

AA_Transporter-Related

Family

4,396

true

false

This family of proteins includes members that are involved in the transport of amino acids across cellular membranes. One characterized member functions as a glutamine transporter, suggesting a role in amino acid uptake and metabolism. Other members are uncharacterized but are predicted to have similar membrane-associa...

[]

0

[ "PANTHER" ]

[ "PTHR37821" ]

[ "AA_Transporter-Related" ]

[ 4396 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4379, 5, 12 ]

3

[]

0

true

Family

Amino Acid Transporter-Related

AA_Transporter-Related

1

IPR052577

52,577

VWA7

Family

6,134

false

This entry represents the VWA7 and related proteins. The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders [ ]. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. The vWF domain is f...

[]

0

[ "PANTHER" ]

[ "PTHR14905" ]

[ "" ]

[ 6134 ]

1

[]

0

[]

0

[ "PUB00001522", "PUB00001619", "PUB00003322", "PUB00003554", "PUB00057248", "PUB00160748" ]

[ "8440408", "1864378", "8145250", "8412987", "12388743", "11261934" ]

[ "von Willebrand factor.", "Shuffled domains in extracellular proteins.", "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by aver...

[ 1993, 1991, 1994, 1993, 2002, 2001 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 205, 5928, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 18, 1, 10, 4, 2, 2 ]

6

true

Family

VWA7

8

IPR052578

52,578

Phosphatidylinositol Transfer CRAL-TRIO Domain-Containing Protein

PI_Transfer_CRAL-TRIO

Family

6,687

true

false

This family of proteins is involved in the transfer of phosphatidylinositol between different membrane compartments, which is crucial for the regulation of the phospholipid composition of plasma- and endomembranes. By modulating the lipid composition, these proteins may play a role in mechanisms of multidrug resistance...

[]

0

[ "PANTHER" ]

[ "PTHR45824" ]

[ "PI_Transfer_CRAL-TRIO" ]

[ 6687 ]

1

[]

0

[ "4fmm", "4j7p", "4j7q", "4m8z" ]

4

[]

0

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 6683, 4 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 20, 1, 17, 2, 1, 32 ]

6

true

Family

Phosphatidylinositol Transfer CRAL-TRIO Domain-Containing Protein

PI_Transfer_CRAL-TRIO

6

IPR052579

52,579

Zinc finger SWIM domain-containing protein

Zinc_finger_SWIM

Family

10,293

true

false

This family of proteins contains a SWIM-type zinc finger domain, which is known to mediate protein-protein interactions. Members of this family are involved in various cellular processes, including regulation of transcription, DNA repair, and ubiquitination. The SWIM domain may function by binding to other proteins or ...

[]

0

[ "PANTHER" ]

[ "PTHR31569" ]

[ "Zinc_finger_SWIM" ]

[ 10293 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 10293 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 5, 3, 2, 5 ]

5

true

Family

Zinc finger SWIM domain-containing protein

Zinc_finger_SWIM

7

IPR052580

52,580

Probable Lipid Hydrolase

Lipid_Hydrolase

Family

4,552

true

false

This family of proteins appears to be involved in lipid metabolism, specifically in the hydrolysis of lipid substrates. The members of this family are characterized by their probable function as lipid hydrolases, which suggests that they may play a role in breaking down complex lipids into simpler molecules. This activ...

[]

0

[ "PANTHER" ]

[ "PTHR46394" ]

[ "Lipid_Hydrolase" ]

[ 4552 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.1.-", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", "PWY-7769", "PWY-7982", "PWY-8058", "PWY-8143...

[ "EC:3.1.1.-", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", "METACYC:PWY-7367", "METACYC:PWY-7521", "METACYC:PWY-7...

28

[ "3tu3", "4akf", "4akx", "4kyi", "4qmk" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 11, 3607, 533, 151, 250 ]

5

[]

0

true

Family

Probable Lipid Hydrolase

Lipid_Hydrolase

4

IPR052582

52,582

tRNA-dihydrouridine synthase-like

tRNA-DUS-like

Family

5,408

true

false

This family of proteins includes enzymes that catalyze the NAD(P)H-dependent synthesis of dihydrouridine, a modified base commonly found in the D-loop of tRNAs. Members of this family specifically modify uridine at position 20 in cytoplasmic tRNAs, contributing to the structural and functional diversity of tRNA molecul...

[]

0

[ "PANTHER" ]

[ "PTHR45936" ]

[ "tRNA-DUS-like" ]

[ 5408 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.1.91", "R-HSA-6782315", "R-HSA-9833482", "R-MMU-9833482" ]

[ "EC:1.3.1.91", "REACTOME:R-HSA-6782315", "REACTOME:R-HSA-9833482", "REACTOME:R-MMU-9833482" ]

4

[ "1whn", "4wfs", "4wft", "4xp7", "5oc4", "5oc5", "5oc6", "6ei8", "6eza", "6ezb", "6ezc", "6f00" ]

12

[]

0

[]

0

null

[ "Eukaryota", "seawater metagenome" ]

[ 5407, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 2, 2, 14, 3, 1, 3, 6, 1, 1, 6 ]

12

true

Family

tRNA-dihydrouridine synthase-like

tRNA-DUS-like

7

IPR052583

52,583

E3 ubiquitin-protein ligase SHPRH-like

SHPRH-like

Family

5,449

true

This entry represents E3 ubiquitin-protein ligase SHPRH and related proteins. Members are involved in pathways that maintain genomic integrity and are implicated in DNA repair processes. The ATP-dependent helicases likely unwind DNA or remodel chromatin, which is crucial during DNA replication, repair, and transcriptio...

[]

0

[ "PANTHER" ]

[ "PTHR45865" ]

[ "ATP-helicase/E3_Ub-Ligase" ]

[ 5449 ]

1

[ "EC", "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "3.6.4.-", "PWY-7250", "PWY-7511", "R-HSA-8866654", "R-MMU-8866654", "R-SCE-8866654", "R-SPO-8866654" ]

[ "EC:2.3.2.27", "EC:3.6.4.-", "METACYC:PWY-7250", "METACYC:PWY-7511", "REACTOME:R-HSA-8866654", "REACTOME:R-MMU-8866654", "REACTOME:R-SCE-8866654", "REACTOME:R-SPO-8866654" ]

8

[ "2m85", "4qn1" ]

2

[]

0

[]

0

null

[ "Absicoccus intestinalis", "Eukaryota", "Imitervirales", "metagenomes" ]

[ 1, 5440, 6, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 3, 5, 3, 1, 5, 4, 1, 1, 27 ]

12

true

Family

E3 ubiquitin-protein ligase SHPRH-like

SHPRH-like

7

IPR052584

52,584

Pre-mRNA Spliceosomal U2 snRNP Complex Component

U2_snRNP_Complex_Component

Family

5,296

true

false

This family of proteins is involved in the splicing of pre-mRNAs, a critical step in gene expression where introns are removed from transcribed pre-mRNAs. Members of this family are essential components of the spliceosome, particularly the 17S U2 snRNP complex, which is crucial for early spliceosome assembly and the re...

[]

0

[ "PANTHER" ]

[ "PTHR12785" ]

[ "U2_snRNP_Complex_Component" ]

[ 5296 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165" ]

4

[ "5gm6", "5lsb", "5lsl", "5nrl", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6ff4", "6ff7", "6g90", "6qx9", "6y50", "6y53", "6y5q", "7abg", "7abh", "7abi", "7dco", "7dvq", "7evo", "7onb", "7oqb", "7oqe", "7q3l", "7q4o", "7q4p", "7qtt", "7vpx"...

53

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5295, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 1, 1, 5, 1, 1, 2, 3, 1, 1, 16 ]

12

true

Family

Pre-mRNA Spliceosomal U2 snRNP Complex Component

U2_snRNP_Complex_Component

2

IPR052586

52,586

Activating signal cointegrator 1 complex subunit 2

ASCC2

Family

5,139

true

false

The ASCC2 family comprises ubiquitin-binding proteins that play a crucial role in DNA repair and the ribosome quality control (RQC) pathway. Members of the family are involved in the rescue of stalled ribosomes and the degradation of nascent peptide chains during problematic translation. They function as part of the AS...

[]

0

[ "PANTHER" ]

[ "PTHR21494" ]

[ "ASCC2" ]

[ 5139 ]

1

[ "REACTOME" ]

[ "R-HSA-112126" ]

[ "REACTOME:R-HSA-112126" ]

1

[ "2di0", "6yxq" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5139 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 2, 1, 5, 2, 1, 8, 5, 1, 16 ]

11

true

Family

Activating signal cointegrator 1 complex subunit 2

ASCC2

2

IPR052587

52,587

TELO2-interacting protein 1 homolog

TELO2-interacting_protein_1

Family

4,860

true

false

This family of proteins is involved in the regulation of cellular responses to nutrient availability and the DNA damage response. Members function as components of complexes such as TORC1, TORC2, and the TTT complex, playing roles in cell growth, survival, and chromatin remodeling. They are essential for the stabilizat...

[]

0

[ "PANTHER" ]

[ "PTHR18460" ]

[ "TELO2-interacting_protein_1" ]

[ 4860 ]

1

[]

0

[ "7f4u", "7ole" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4860 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 2, 1, 4, 2, 1, 1, 43 ]

12

true

Family

TELO2-interacting protein 1 homolog

TELO2-interacting_protein_1

5

IPR052588

52,588

Kelch domain-containing protein

Kelch_domain_protein

Family

4,603

true

false

This family of proteins includes members that contain Kelch motifs, which are typically involved in protein-protein interactions. The Kelch motif is a sequence of approximately 50 amino acids that forms a beta-propeller structure. Proteins with Kelch domains are known to participate in a variety of cellular functions, ...

[]

0

[ "PANTHER" ]

[ "PTHR46063" ]

[ "Kelch_domain_protein" ]

[ 4603 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 6, 4597 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 2, 1, 8, 5, 1, 6, 7, 1, 14 ]

10

true

Family

Kelch domain-containing protein

Kelch_domain_protein

8

IPR052590

52,590

Stress and Virulence-Associated Domain-Containing Protein

Stress/Virulence-Domain

Family

2,204

true

false

This family of proteins includes members that are involved in various cellular responses to environmental stimuli. Some proteins in this family are implicated in adaptive responses to nutrient deprivation, potentially playing a role in cellular survival mechanisms under stress conditions. Other members are suggested to...

[]

0

[ "PANTHER" ]

[ "PTHR36569" ]

[ "Stress/Virulence-Domain" ]

[ 2204 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 17, 1575, 603, 9 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Stress and Virulence-Associated Domain-Containing Protein

Stress/Virulence-Domain

9

IPR052591

52,591

Probable calcium-binding protein CML21-like

CML21-like

Family

1,833

false

This entry represents a family of proteins mainly found in plants, including Probable calcium-binding protein CML21 from Arabidopsis thaliana, which is probably involved in calcium-dependent signalling processes.

[]

0

[ "PANTHER" ]

[ "PTHR23064" ]

[ "" ]

[ 1833 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "environmental samples" ]

[ 84, 1746, 3 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 7, 14 ]

3

true

Family

Probable calcium-binding protein CML21-like

CML21-like

4

IPR052592

52,592

LRR Receptor-like Kinase

LRR-RLK

Family

3,660

true

false

This family of proteins includes receptor-like kinases that are implicated in various cellular processes. Members of this family are characterized by the presence of leucine-rich repeat (LRR) domains, which suggest a role in protein-protein interactions, and kinase domains that indicate a function in phosphorylation si...

[]

0

[ "PANTHER" ]

[ "PTHR48054" ]

[ "LRR-RLK" ]

[ 3660 ]

1

[]

0

[ "4u08" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Gaeavirus sp.", "ecological metagenomes" ]

[ 101, 3535, 1, 23 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 11, 14, 2, 11 ]

4

true

Family

LRR Receptor-like Kinase

LRR-RLK

1

IPR052593

52,593

Microtubule-associated AKAP9-binding protein

MT-associated_AKAP9-binding

Family

4,471

true

false

This family of proteins is involved in the regulation of microtubule dynamics and cellular architecture. Members of this family function as scaffolding proteins that anchor key signaling molecules, particularly those involved in the cAMP-dependent pathway, to specific cellular structures like the Golgi apparatus and ce...

[]

0

[ "PANTHER" ]

[ "PTHR46501" ]

[ "MT-associated_AKAP9-binding" ]

[ 4471 ]

1

[]

0

[ "5i7c", "5mvw", "5mw0", "5mw9", "5mwe" ]

5

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4471 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 147, 7, 18, 8, 15 ]

5

true

Family

Microtubule-associated AKAP9-binding protein

MT-associated_AKAP9-binding

2

IPR052594

52,594

J domain-containing protein

J_domain-containing_protein

Family

4,513

true

false

This family of proteins includes J domain-containing proteins that function as molecular co-chaperones. They are involved in the assembly of histones onto DNA, which is a critical step in the formation of nucleosomes and chromatin structure. These proteins form complexes with histone H3-H4 heterodimers and other chaper...

[]

0

[ "PANTHER" ]

[ "PTHR44144" ]

[ "J_domain-containing_protein" ]

[ 4513 ]

1

[]

0

[ "7ciz", "7cj0" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 114, 4391, 2, 6 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 2, 2, 1, 5, 1 ]

8

true

Family

J domain-containing protein

J_domain-containing_protein

8

IPR052595

52,595

Leucine-rich repeat-containing protein 69/Receptor-like

LRRC69/RLP

Family

3,960

true

false

The LRRC69/RLP family is involved in the perception and response to extracellular signals that regulate meristem maintenance and root growth. Members of the family, such as CLV2 in Arabidopsis, are receptor-like proteins that detect CLV3 and CLV3-like peptides. These peptides are crucial for controlling stem cell popul...

[]

0

[ "PANTHER" ]

[ "PTHR48057" ]

[ "LRRC69/RLP" ]

[ 3960 ]

1

[ "REACTOME" ]

[ "R-HSA-5223345" ]

[ "REACTOME:R-HSA-5223345" ]

1

[ "4z5w", "4z61", "4z62", "5ixo", "5ixq", "5ixt", "5iyv", "5iyx" ]

8

[]

0

[]

0

null

[ "Bacteria", "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 410, 1, 3516, 14, 19 ]

5

[ "Arabidopsis thaliana", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 3, 3, 12, 15 ]

5

true

Family

Leucine-rich repeat-containing protein 69/Receptor-like

LRRC69/RLP

3

IPR052596

52,596

Activating Molecule in BECN1-Regulated Autophagy

AMBRA1_autophagy

Family

4,235

true

false

The AMBRA1 family proteins are substrate-recognition components of the DCX E3 ubiquitin-protein ligase complex, playing a pivotal role in cell cycle control and autophagy. They mediate polyubiquitination and degradation of various target proteins, including BECN1 and cyclin-D, thereby regulating the G1 to S phase trans...

[]

0

[ "PANTHER" ]

[ "PTHR22874" ]

[ "AMBRA1_autophagy" ]

[ 4235 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-1632852", "R-HSA-1632852", "R-MMU-1632852" ]

[ "REACTOME:R-DRE-1632852", "REACTOME:R-HSA-1632852", "REACTOME:R-MMU-1632852" ]

3

[ "8wqr", "9ivd" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4235 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 3, 4, 1, 6, 5, 48 ]

7

true

Family

Activating Molecule in BECN1-Regulated Autophagy

AMBRA1_autophagy

3

IPR052598

52,598

Immunoglobulin superfamily CEA-related

IgSF_CEA-related

Family

4,737

true

false

This family of proteins is part of the immunoglobulin superfamily and is involved in cell adhesion processes. Members of this family are characterized by the presence of immunoglobulin-like domains, which are typically responsible for mediating interactions between cells or between cells and the extracellular matrix. T...

[]

0

[ "PANTHER" ]

[ "PTHR44337" ]

[ "IgSF_CEA-related" ]

[ 4737 ]

1

[]

0

[ "4u7m", "8bw0" ]

2

[]

0

[]

0

null

[ "Bacteria", "Enhodamvirus", "Eukaryota", "Methanolapillus ohkumae", "marine metagenome" ]

[ 24, 6, 4705, 1, 1 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 34, 22, 3, 8 ]

5

true

Family

Immunoglobulin superfamily CEA-related

IgSF_CEA-related

8

IPR052599

52,599

SLC43A Amino Acid Transporter

SLC43A_AATransporter

Family

3,647

true

false

This family of proteins includes transporters that are part of the SLC43A transporter group, classified under TC 2.A.1.44. Members of this family are involved in the transport of various amino acids across cellular membranes. They are characterized by their ability to transport cationic amino acids such as L-arginine, ...

[]

0

[ "PANTHER" ]

[ "PTHR20772" ]

[ "SLC43A_AATransporter" ]

[ 3647 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 3645 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

SLC43A Amino Acid Transporter

SLC43A_AATransporter

8

IPR052600

52,600

Nuclear receptor coactivator/corepressor

Nuc_rcpt_coact/corep

Family

3,590

true

false

This family of proteins serves as nuclear receptor coregulators, possessing the ability to interact with nuclear receptors and modulate their activity. These proteins contain a conserved Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif, which is crucial for their association with nuclear receptors. They are involved in the coactivati...

[]

0

[ "PANTHER" ]

[ "PTHR23295" ]

[ "Nuc_rcpt_coact/corep" ]

[ 3590 ]

1

[]

0

[ "1v95" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3590 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 10, 2, 2, 5, 4 ]

6

true

Family

Nuclear receptor coactivator/corepressor

Nuc_rcpt_coact/corep

7

IPR052601

52,601

Plasmanylethanolamine desaturase

Plasmalogen_desaturase

Family

3,398

true

false

This family of proteins includes enzymes that are involved in the biogenesis of plasmalogens within the endoplasmic reticulum membrane. Plasmalogens are a type of glycerophospholipid characterized by a vinyl ether bond at the glycerol sn-1 position. These enzymes exhibit desaturase activity, introducing a double bond i...

[]

0

[ "PANTHER" ]

[ "PTHR48177" ]

[ "Plasmalogen_desaturase" ]

[ 3398 ]

1

[ "EC", "METACYC" ]

[ "1.14.19.77", "PWY-7782" ]

[ "EC:1.14.19.77", "METACYC:PWY-7782" ]

2

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Mimiviridae", "metagenomes" ]

[ 184, 3207, 2, 5 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 4, 2, 5 ]

5

true

Family

Plasmanylethanolamine desaturase

Plasmalogen_desaturase

1

IPR052602

52,602

Growth and transcription regulation protein

Growth_transcription_reg

Family

3,584

true

false

This family of proteins includes members involved in various cellular processes. Some proteins in this family are necessary for normal growth rates when utilizing specific sugars such as galactose and mannose. Other members are implicated in the regulation of gene expression, potentially acting as coactivators for horm...

[]

0

[ "PANTHER" ]

[ "PTHR46515" ]

[ "Growth_transcription_reg" ]

[ 3584 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6811440", "R-MMU-6811440", "R-SCE-6811440" ]

[ "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6811440", "REACTOME:R-SCE-6811440" ]

3

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Streptococcus canis" ]

[ 3583, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 5, 2, 1, 5, 1, 1 ]

8

true

Family

Growth and transcription regulation protein

Growth_transcription_reg

1

IPR052603

52,603

EF-hand calcium-binding domain-containing protein 6

EFCB6

Family

3,117

true

false

This family of proteins is involved in the regulation of the androgen receptor through a negative feedback mechanism that includes the recruitment of a histone deacetylase complex. Members of this family are also implicated in the structural integrity of cilia, specifically as microtubule inner proteins within the axon...

[]

0

[ "PANTHER" ]

[ "PTHR20875" ]

[ "EFCB6" ]

[ 3117 ]

1

[]

0

[ "1wlz", "5d67", "6u42", "7n61", "7rro", "7som", "8g2z", "8g3d", "8glv", "8i7o", "8i7r", "8iyj", "8otz", "8sf7", "8to0", "9cpb", "9cpc", "9d5n", "9e5c", "9e78", "9fqr" ]

21

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3117 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 2, 5, 1, 4 ]

5

true

Family

EF-hand calcium-binding domain-containing protein 6

EFCB6

5

IPR052604

52,604

Mitochondrial Tim protein assembly helper

Mito_Tim_assembly_helper

Family

2,928

true

false

This family of proteins is involved in mitochondrial protein import and assembly processes. Specifically, they assist in the assembly or recycling of small Tim proteins within the mitochondrial intermembrane space. These proteins play a crucial role in the correct import and insertion of multi-pass transmembrane protei...

[]

0

[ "PANTHER" ]

[ "PTHR28082" ]

[ "Mito_Tim_assembly_helper" ]

[ 2928 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "human gut metagenome" ]

[ 1086, 1671, 170, 1 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Family

Mitochondrial Tim protein assembly helper

Mito_Tim_assembly_helper

5

IPR052605

52,605

NDT80-like transcription factors

NDT80-like

Family

3,467

true

This family of proteins includes transcription factors that are key regulators of various cellular processes in fungi. Members of this family act as positive regulators of acid phosphatase activity and are crucial for the response to nitrogen and carbon starvation. They play a significant role in vegetative incompatibi...

[]

0

[ "PANTHER" ]

[ "PTHR35144" ]

[ "Fungal_trans_regulator" ]

[ 3467 ]

1

[]

0

[ "1m6u", "1m7u", "1mn4", "1mnn", "2etw", "2euv", "2euw", "2eux", "2euz", "2evf", "2evg", "2evh", "2evi", "2evj" ]

14

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3467 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 7, 1 ]

2

true

Family

NDT80-like transcription factors

NDT80-like

8

IPR052606

52,606

DnaJ domain-containing protein

DnaJ_domain_protein

Family

3,493

true

false

This family of proteins includes members that are part of the DnaJ family, which are known to be involved in molecular chaperone activities. These proteins typically contain a J domain and are implicated in the modulation of protein synthesis and folding. They play a crucial role in assisting the Hsp70 chaperone machin...

[]

0

[ "PANTHER" ]

[ "PTHR44653" ]

[ "DnaJ_domain_protein" ]

[ 3493 ]

1

[]

0

[ "2cqq", "2cqr" ]

2

[]

0

[]

0

null

[ "Acinetobacter", "Eukaryota" ]

[ 2, 3491 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 1, 4, 5, 1, 3, 1, 1 ]

9

true

Family

DnaJ domain-containing protein

DnaJ_domain_protein

5

IPR052607

52,607

Centrosomal protein 104 kDa-like

CEP104-like

Family

3,360

true

false

This family of proteins is involved in the process of ciliogenesis, which is the formation of cilia on the cell surface. These proteins also play a crucial role in maintaining the structural integrity at the ciliary tip, which is essential for the proper function of cilia. Cilia are hair-like structures that extend fro...

[]

0

[ "PANTHER" ]

[ "PTHR13371" ]

[ "CEP104-like" ]

[ 3360 ]

1

[]

0

[ "5jo8", "5lph", "5lpi", "6whb" ]

4

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3360 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 1, 14, 5, 8 ]

6

true

Family

Centrosomal protein 104 kDa-like

CEP104-like

3

IPR052608

52,608

U-box domain-containing protein

U-box_domain_protein

Family

4,219

true

false

This family of proteins includes E3 ubiquitin ligases that are involved in the post-translational modification of proteins by attaching ubiquitin molecules. These modifications often target proteins for degradation via the ubiquitin-26S proteasome pathway. Members of this family play roles in various cellular processes...

[]

0

[ "PANTHER" ]

[ "PTHR45958" ]

[ "U-box_domain_protein" ]

[ 4219 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Gammaproteobacteria", "Mimivirus LCMiAC02", "viral metagenome" ]

[ 4215, 2, 1, 1 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 19, 30 ]

3

true

Family

U-box domain-containing protein

U-box_domain_protein

1

IPR052610

52,610

Basic helix-loop-helix transcription regulator

bHLH_transcription_regulator

Family

4,322

true

false

This family of proteins includes transcription factors characterized by the basic helix-loop-helix (bHLH) domain, which is involved in DNA binding and dimerization. Members of this family are known to regulate the expression of various genes and are involved in multiple biological processes. One member is specifically ...

[]

0

[ "PANTHER" ]

[ "PTHR45959" ]

[ "bHLH_transcription_regulator" ]

[ 4322 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 4322 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 21, 50 ]

3

true

Family

Basic helix-loop-helix transcription regulator

bHLH_transcription_regulator

5

IPR052611

52,611

Plant receptor-like kinase with LysM domain-containing protein

Plant_RLK_LysM

Family

4,262

true

false

This family of proteins includes receptor-like kinases with a role in plant innate immunity and symbiotic interactions. Members are involved in the perception of microbial signals, such as Nod factors and chitooligosaccharides, which are crucial for initiating plant defense responses and symbiotic nodule formation. Som...

[]

0

[ "PANTHER" ]

[ "PTHR45927" ]

[ "Plant_RLK_LysM" ]

[ 4262 ]

1

[]

0

[ "7au7", "7bax", "8ps7", "8s79", "9gxf", "9gxz", "9h39", "9h3a", "9q83", "9q84" ]

10

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4262 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 17, 67 ]

3

true

Family

Plant receptor-like kinase with LysM domain-containing protein

Plant_RLK_LysM

5

IPR052612

52,612

Atrial Natriuretic Peptide Clearance Receptor

ANP_Clearance_Receptor

Family

3,460

true

false

This family of proteins serves as receptors for natriuretic peptide hormones, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). They bind these peptides with similar affinities and are implicated in the clearance of these hormones, thereby regulating thei...

[]

0

[ "PANTHER" ]

[ "PTHR44755" ]

[ "ANP_Clearance_Receptor" ]

[ 3460 ]

1

[]

0

[ "1dp4", "1jdn", "1jdp", "1t34", "1yk0", "1yk1", "3a3k", "7brg", "7brh", "7bri", "7brj", "7brk", "7brl", "8tg9", "8tga" ]

15

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3459, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 10, 5, 7 ]

5

true

Family

Atrial Natriuretic Peptide Clearance Receptor

ANP_Clearance_Receptor

9

IPR052613

52,613

LicD transferase

LicD_transferase

Family

2,808

true

false

This family of proteins includes enzymes that catalyze the transfer of ribitol 5-phosphate from CDP-L-ribitol to a phosphorylated O-mannosyl trisaccharide structure present in alpha-dystroglycan, which is a crucial step in the post-translational modification of this protein. The modification involves the formation of a...

[]

0

[ "PANTHER" ]

[ "PTHR13627" ]

[ "LicD_transferase" ]

[ 2808 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9939291", "R-MMU-9939291" ]

[ "REACTOME:R-HSA-9939291", "REACTOME:R-MMU-9939291" ]

2

[ "6kaj", "6kak", "6kal", "6kam", "6kan", "6l7s", "6l7t", "6l7u" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Marine Group I thaumarchaeote", "Megaviricetes", "unclassified sequences" ]

[ 379, 2383, 1, 7, 38 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 4, 2 ]

5

true

Family

LicD transferase

LicD_transferase

6

IPR052614

52,614

Cilia-Flagella-Associated Protein 65

CFAP65

Family

2,515

false

Cilia-Flagella-Associated Protein 65 (CFAP65) is involved in the structural and functional integrity of cilia and flagella. This protein is implicated in the process of flagellar formation and is essential for proper sperm motility, suggesting a role in reproductive biology. CFAP65's function in flagellar assembly indi...

[]

0

[ "PANTHER" ]

[ "PTHR46127" ]

[ "" ]

[ 2515 ]

1

[]

0

[ "7n61", "7som", "9ijj" ]

3

[ "PUB00160504" ]

[ "22761584" ]

[ "The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 338, 2160, 14, 3 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 10, 4, 4 ]

4

true

Family

Cilia-Flagella-Associated Protein 65

CFAP65

7

IPR052615

52,615

Fibroblast growth factor receptor-like

FGFRL

Family

3,228

true

false

This family of proteins is characterized by a conserved role in negatively regulating cell proliferation. Members of this family are found across different species, suggesting a conserved biological function in growth control mechanisms. The proteins in this family share a homologous structure that is likely to be invo...

[]

0

[ "PANTHER" ]

[ "PTHR19890" ]

[ "FGFRL" ]

[ 3228 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-5658623", "R-HSA-5658623", "R-MMU-5658623", "R-RNO-5658623" ]

[ "REACTOME:R-GGA-5658623", "REACTOME:R-HSA-5658623", "REACTOME:R-MMU-5658623", "REACTOME:R-RNO-5658623" ]

4

[ "1cvs", "1djs", "1e0o", "1ev2", "1evt", "1fq9", "1ii4", "1iil", "1nun", "1ry7", "1wvz", "2fdb", "3caf", "3cu1", "3dar", "3euu", "3grw", "3oj2", "3ojm", "3ojv", "4hwu", "4j23", "4wv1", "5w21", "5w59", "6j6y", "7n1j", "7tyd", "7ysh", "7ysu", "7ysw" ]

31

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 3228 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 1, 38, 16, 17 ]

6

true

Family

Fibroblast growth factor receptor-like

FGFRL

9

IPR052616

52,616

SYO1-like

Family

3,072

false

SYO1 and HEATR3 are involved in ribosome biogenesis and nuclear import, functioning as adaptor proteins that facilitate the transport of ribosomal components into the nucleus. Specifically, SYO1 acts as a nuclear import adaptor that recruits the functionally and topologically linked ribosomal proteins RPL5 and RPL11 [ ...

[]

0

[ "PANTHER", "CDD" ]

[ "PTHR13347", "cd13394" ]

[ "", "Syo1_like" ]

[ 3070, 2141 ]

2

[]

0

[ "4gmn", "4gmo", "5aff", "7ozs" ]

4

[ "PUB00123344", "PUB00160882" ]

[ "23118189", "35213692" ]

[ "Synchronizing nuclear import of ribosomal proteins with ribosome assembly.", "HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia." ]

[ 2012, 2022 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3072 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 4, 6, 1, 3, 1, 1 ]

8

true

Family

SYO1-like

8

IPR052617

52,617

Huntingtin-interacting protein K

Huntingtin-int_K

Family

3,191

true

false

The Huntingtin-interacting protein K family comprises components of N-terminal acetyltransferase complexes, specifically inhibiting the N-terminal acetylation activity of the NatA complex. Members of the family exhibit chaperone-like activity that prevents polyglutamine aggregation in neuronal cells, potentially while ...

[]

0

[ "PANTHER" ]

[ "PTHR31184" ]

[ "Huntingtin-int_K" ]

[ 3191 ]

1

[]

0

[ "5nnr", "6c95", "6pw9", "9f1d" ]

4

[]

0

[]

0

null

[ "Eukaryota", "Methanocaldococcaceae", "viral metagenome" ]

[ 3183, 7, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 1, 3, 2, 1, 2, 3, 8 ]

10

true

Family

Huntingtin-interacting protein K

Huntingtin-int_K

6

IPR052618

52,618

Complex I NDUFA12 subunit

ComplexI_NDUFA12

Family

2,908

true

false

The NDUFA12 subunit family is involved in the assembly and function of mitochondrial complex I, which is a critical component of the respiratory chain. Members of the family act as molecular chaperones, facilitating the correct assembly of complex I. This complex plays a pivotal role in cellular energy production by tr...

[]

0

[ "PANTHER" ]

[ "PTHR32470" ]

[ "ComplexI_NDUFA12" ]

[ 2908 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6799198", "R-MMU-6799198" ]

[ "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198" ]

2

[ "6rfq", "8ca5" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2908 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 1, 10, 5, 1, 3, 1 ]

8

true

Family

Complex I NDUFA12 subunit

ComplexI_NDUFA12

2

IPR052620

52,620

ELYS/MEL-28 Nuclear Assembly Factor

ELYS/MEL-28_NucAsmblyFactor

Family

2,757

true

false

The ELYS family proteins are essential for the assembly of a functional nuclear pore complex (NPC) on chromatin surfaces as nuclei form post-mitosis. They may initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex. Additionally, they play a role in localizing the Nup107-160 subcomplex to...

[]

0

[ "PANTHER" ]

[ "PTHR21583" ]

[ "ELYS/MEL-28_NucAsmblyFactor" ]

[ 2757 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9615933", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9615933", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9615933", "R-MMU-9648025" ]

[ "REACTOME:R-DME-9615933", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9615933", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-...

15

[ "4i0o", "7r5j", "7r5k", "7tbl", "7vci", "7wb4" ]

6

[]

0

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 2754, 3 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 1, 2, 5, 4, 4 ]

6

true

Family

ELYS/MEL-28 Nuclear Assembly Factor

ELYS/MEL-28_NucAsmblyFactor

3

IPR052621

52,621

Cell Proliferation and Cornified Envelope Regulator

Cell_Prolif/Cornif_Regul

Family

2,842

true

false

The protein family in question appears to be involved in diverse biological processes related to cellular structures and functions. Members of the family are implicated in the regulation of cellular proliferation and differentiation, which are fundamental aspects of cell biology influencing tissue development and homeo...

[]

0

[ "PANTHER" ]

[ "PTHR15468" ]

[ "Cell_Prolif/Cornif_Regul" ]

[ 2842 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2842 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 12, 14, 12 ]

4

true

Family

Cell Proliferation and Cornified Envelope Regulator

Cell_Prolif/Cornif_Regul

9

IPR052622

52,622

Glycosyltransferase group 1 domain-containing protein

Glycosyltransferase_G1

Family

1,926

true

false

This family of proteins includes enzymes that are part of the glycosyltransferase group 1. Members of this family are characterized by their ability to catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. This process is crucial for the biosynt...

[]

0

[ "PANTHER" ]

[ "PTHR46660" ]

[ "Glycosyltransferase_G1" ]

[ 1926 ]

1

[]

0

[ "8fbx", "8jjn", "8jjq", "8jjt", "8k5u", "8rz3" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 445, 1475, 6 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 1, 3 ]

4

true

Family

Glycosyltransferase group 1 domain-containing protein

Glycosyltransferase_G1

9

IPR052623

52,623

Dynein axonemal assembly factor 5

DAAF5

Family

2,743

true

This family includes Dynein axonemal assembly factor 5 (DAAF5). Members of this family are cytoplasmic and play a crucial role in the formation of the dynein inner and outer arms, which are essential for the movement of cilia. These arms are attached to the peripheral outer doublet A microtubule of the axoneme, the cor...

[]

0

[ "PANTHER" ]

[ "PTHR16216" ]

[ "DNAAF" ]

[ 2743 ]

1

[]

0

[]

0

[ "PUB00154951", "PUB00154952" ]

[ "23040496", "25232951" ]

[ "Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.", "HEATR2 plays a conserved role in assembly of the ciliary motile apparatus." ]

[ 2012, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2743 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 7, 3, 6 ]

5

true

Family

Dynein axonemal assembly factor 5

DAAF5

1

IPR052624

52,624

Cysteine-rich motor neuron 1

CRIM1

Family

2,564

true

false

This family of proteins is implicated in central nervous system (CNS) development, specifically in the differentiation and survival of motor neurons. Members of this family interact with growth factors that are critical for these processes. Additionally, some members are involved in angiogenesis, contributing to capill...

[]

0

[ "PANTHER" ]

[ "PTHR46439" ]

[ "CRIM1" ]

[ 2564 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2564 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 7, 1, 9, 7, 4 ]

6

true

Family

Cysteine-rich motor neuron 1

CRIM1

8

IPR052625

52,625

Chlorophyll b Reductase

Chl_b_Red

Family

2,192

true

false

This family of proteins is involved in the degradation of chlorophyll b, a process essential for the proper turnover and recycling of chlorophyll molecules during plant development and stress responses. Members of this family function as chlorophyll(ide) b reductases, enzymes that catalyze the reduction of chlorophyll ...

[]

0

[ "PANTHER" ]

[ "PTHR24314" ]

[ "Chl_b_Red" ]

[ 2192 ]

1

[ "EC", "METACYC" ]

[ "1.1.1.294", "PWY-5068" ]

[ "EC:1.1.1.294", "METACYC:PWY-5068" ]

2

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 24, 358, 1779, 31 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 3, 11 ]

3

true

Family

Chlorophyll b Reductase

Chl_b_Red

2

IPR052626

52,626

SWT1 Transcriptional Regulator

SWT1_Regulator

Family

2,671

true

false

This family of proteins is involved in transcriptional regulation. Members are likely to function as transcriptional activators, playing a role in the control of gene expression by modulating the transcription process.

[]

0

[ "PANTHER" ]

[ "PTHR16161" ]

[ "SWT1_Regulator" ]

[ 2671 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Medusavirus", "metagenomes" ]

[ 91, 2570, 2, 8 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 13, 3, 4, 3, 5, 1, 1 ]

8

true

Family

SWT1 Transcriptional Regulator

SWT1_Regulator

2

IPR052627

52,627

von Willebrand factor A domain-containing protein

VWA_domain-containing

Family

2,542

true

false

This family of proteins includes members that contain the von Willebrand factor A (VWA) domain, which is typically involved in cell adhesion and migration. These proteins are known to participate in various biological processes including signal transduction, extracellular matrix formation, and possibly in the blood coa...

[]

0

[ "PANTHER" ]

[ "PTHR46299" ]

[ "VWA_domain-containing" ]

[ 2542 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 2542 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 10, 10, 5 ]

4

true

Family

von Willebrand factor A domain-containing protein

VWA_domain-containing

9

IPR052628

52,628

Cilia- and flagella-associated protein 70

CFAP70

Family

2,393

true

false

This family of proteins is involved in the structural and functional organization of cilia and flagella. Members of this family are axoneme-binding proteins that contribute to the regulation of ciliary and flagellar motility, as well as the determination of cilium length. While the conserved TPR domains within these pr...

[]

0

[ "PANTHER" ]

[ "PTHR44314" ]

[ "CFAP70" ]

[ 2393 ]

1

[ "REACTOME" ]

[ "R-DDI-6804760" ]

[ "REACTOME:R-DDI-6804760" ]

1

[ "7n61", "7som", "9ijj" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 97, 2293, 3 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 6, 2, 5 ]

5

true

Family

Cilia- and flagella-associated protein 70

CFAP70

1

IPR052630

52,630

Tetratricopeptide repeat protein 17

TTC17

Family

2,575

true

false

The TTC17 family is implicated in the process of primary ciliogenesis, specifically through the modulation of actin polymerization. The proper formation and function of primary cilia are crucial for various cellular signaling pathways, and defects in ciliogenesis can lead to a range of ciliopathies. By influencing acti...

[]

0

[ "PANTHER" ]

[ "PTHR16091" ]

[ "TTC17" ]

[ 2575 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2575 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 9, 4, 6 ]

6

true

Family

Tetratricopeptide repeat protein 17

TTC17

7

IPR052631

52,631

Paired homeobox Bicoid subfamily

Paired_homeobox_Bicoid

Family

2,636

true

false

This family of proteins includes transcription factors that are characterized by the presence of a homeobox domain, which is indicative of their role in DNA binding and regulation of gene expression. Members of this family are implicated in growth regulation and developmental processes, including the formation of body ...

[]

0

[ "PANTHER" ]

[ "PTHR46255" ]

[ "Paired_homeobox_Bicoid" ]

[ 2636 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2636 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 3, 5, 5, 5 ]

5

true

Family

Paired homeobox Bicoid subfamily

Paired_homeobox_Bicoid

8

IPR052632

52,632

MICOS complex subunit Mic19

MICOS_subunit_Mic19

Family

2,314

true

false

This family of proteins is involved in the structural organization of the mitochondrial inner membrane. Members function as components of the MICOS complex, which is essential for the formation and maintenance of crista junctions, the overall architecture of the inner membrane, and the establishment of contact sites wi...

[]

0

[ "PANTHER" ]

[ "PTHR21588" ]

[ "MICOS_subunit_Mic19" ]

[ 2314 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-1268020", "R-HSA-8949613" ]

[ "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-8949613" ]

2

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 2314 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 13, 2, 6, 6, 6 ]

6

true

Family

MICOS complex subunit Mic19

MICOS_subunit_Mic19

2

IPR052633

52,633

GRAM domain-containing protein 2B

GRAM_domain_protein_2B

Family

2,440

true

false

This family of proteins includes GRAM domain-containing protein 2B across various species. The GRAM domain is a protein domain that typically binds phosphoinositides, which are important signaling molecules in cells. Proteins with GRAM domains are often involved in membrane-associated processes due to their lipid-bindi...

[]

0

[ "PANTHER" ]

[ "PTHR46645" ]

[ "GRAM_domain_protein_2B" ]

[ 2440 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2439, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 8, 5, 8 ]

4

true

Family

GRAM domain-containing protein 2B

GRAM_domain_protein_2B

7

IPR052634

52,634

Sperm flagellar development and bone growth associated protein

Sperm_flagellar-bone_growth

Family

2,340

true

false

This family of proteins is involved in the structural and functional integrity of sperm flagella, specifically in axoneme development, which is crucial for sperm motility. These proteins are also key for the proper formation of the manchette and sperm head, impacting sperm morphology. Their essential role in male ferti...

[]

0

[ "PANTHER" ]

[ "PTHR14919" ]

[ "Sperm_flagellar-bone_growth" ]

[ 2340 ]

1

[]

0

[ "7n6g", "7sqc", "9ijj" ]

3

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2340 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 8, 4, 6 ]

4

true

Family

Sperm flagellar development and bone growth associated protein

Sperm_flagellar-bone_growth

7

IPR052635

52,635

Secondary Metabolite Biosynthesis Regulator

Sec_Metab_Biosynth_Reg

Family

2,407

true

false

This family of proteins includes transcription factors that regulate the expression of gene clusters involved in the biosynthesis of various secondary metabolites with biological activities. Members of this family are characterized by their ability to up-regulate genes responsible for the production of compounds such a...

[]

0

[ "PANTHER" ]

[ "PTHR39607" ]

[ "Sec_Metab_Biosynth_Reg" ]

[ 2407 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2407 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Family

Secondary Metabolite Biosynthesis Regulator

Sec_Metab_Biosynth_Reg

5

IPR052636

52,636

UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase

UDP-D-xylose:L-fucose_XylT

Family

2,450

true

false

This family of proteins includes enzymes that catalyze the transfer of D-xylose from UDP-alpha-D-xylose to L-fucose, a reaction likely involved in the biosynthesis of rhamnogalacturonan II (RG-II). RG-II is a complex pectic polysaccharide found in the primary cell wall and is crucial for cell wall integrity, particular...

[]

0

[ "PANTHER" ]

[ "PTHR47032" ]

[ "UDP-D-xylose:L-fucose_XylT" ]

[ 2450 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.2.-", "PWY-5381", "PWY-5800", "PWY-6148", "PWY-6720", "PWY-7018", "PWY-7025", "PWY-7450", "PWY-7817", "PWY-7981" ]

[ "EC:2.4.2.-", "METACYC:PWY-5381", "METACYC:PWY-5800", "METACYC:PWY-6148", "METACYC:PWY-6720", "METACYC:PWY-7018", "METACYC:PWY-7025", "METACYC:PWY-7450", "METACYC:PWY-7817", "METACYC:PWY-7981" ]

10

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "viral metagenome" ]

[ 26, 2383, 7, 34 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 2, 4 ]

3

true

Family

UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase

UDP-D-xylose:L-fucose_XylT

1

IPR052637

52,637

Kelch domain-containing protein 3-like

KLHDC3-like

Family

2,491

false

This entry represents human Kelch domain-containing protein 3 (KLHDC3) and similar proteins mainly found in animals. KLHDC3, also known as Testis intracellular mediator protein or PEAS, is the substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end...

[ "GO:0003682" ]

[ "chromatin binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR46461" ]

[ "" ]

[ 2491 ]

1

[ "REACTOME" ]

[ "R-HSA-381038" ]

[ "REACTOME:R-HSA-381038" ]

1

[ "9d1i", "9d1y", "9d1z" ]

3

[ "PUB00155308", "PUB00155309", "PUB00155310", "PUB00155311" ]

[ "12606021", "26138980", "29775578", "29779948" ]

[ "A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin.", "SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.", "C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.", "The...

[ 2003, 2015, 2018, 2018 ]

4

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "marine sediment metagenome" ]

[ 38, 3, 2449, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 1, 6, 5, 4 ]

6

true

Family

Kelch domain-containing protein 3-like

KLHDC3-like

8

IPR052638

52,638

PiggyBac transposable element-derived

PiggyBac_TE-derived

Family

2,895

true

false

The PiggyBac transposable element-derived protein family is involved in DNA damage repair and gene expression regulation. Members of the family can bind to PGBD3-related transposable elements known as MER85s, which are non-autonomous 140 bp elements with PGBD3 terminal inverted repeats and no internal transposase ORF. ...

[]

0

[ "PANTHER" ]

[ "PTHR47055" ]

[ "PiggyBac_TE-derived" ]

[ 2895 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 2895 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 4, 1 ]

3

true

Family

PiggyBac transposable element-derived

PiggyBac_TE-derived

3

IPR052639

52,639

TRAIP E3 ubiquitin-protein ligase

TRAIP_ubiq-protein_ligase

Family

2,416

true

false

The TRAIP family proteins are E3 ubiquitin ligases that play a crucial role in maintaining genome stability under replication stress. They regulate interstrand cross-link repair by ubiquitinating the MCM7 subunit of the CMG helicase complex, which influences the choice between repair pathways. The ubiquitination of MCM...

[]

0

[ "PANTHER" ]

[ "PTHR46569" ]

[ "TRAIP_ubiq-protein_ligase" ]

[ 2416 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-983168", "R-HSA-983168", "R-MMU-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

5

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2416 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 7, 2, 3 ]

6

true

Family

TRAIP E3 ubiquitin-protein ligase

TRAIP_ubiq-protein_ligase

6

IPR052640

52,640

Gem-associated protein 5

Gemin-5

Family

2,352

false

This entry represents Gemin-5, a protein involved in the assembly and function of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome, the complex responsible for the splicing of pre-mRNA in eukaryotic cells [ , ]. They recognise and bind to snRNAs and the 7-methylguanosine cap ...

[]

0

[ "PANTHER" ]

[ "PTHR46362" ]

[ "" ]

[ 2352 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]

[ "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]

3

[ "5gxh", "5gxi", "5h1j", "5h1k", "5h1l", "5h1m", "5h3s", "5h3t", "5h3u", "5tee", "5tef", "5tha", "6rnq", "6rns", "7xdt", "7xgr" ]

16

[ "PUB00103799", "PUB00155010", "PUB00155011", "PUB00155012", "PUB00155013", "PUB00155014", "PUB00155015" ]

[ "30563832", "14645129", "24391840", "27834343", "27881600", "27881601", "33963192" ]

[ "Composition of the Survival Motor Neuron (SMN) Complex in <i>Drosophila melanogaster</i>.", "rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.", "The Gemin associates of survival motor neuron are required for motor function i...

[ 2019, 2004, 2013, 2016, 2016, 2016, 2021 ]

7

[]

0

null

[ "Eukaryota" ]

[ 2352 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 3, 8, 2 ]

5

true

Family

Gem-associated protein 5

Gemin-5

7

IPR052641

52,641

A-kinase anchor protein 7 isoform gamma

AKAP7_isoform_gamma

Family

2,510

true

false

This family of proteins is involved in targeting cAMP-dependent protein kinase (PKA) to specific cellular locations, such as the membrane or cytoskeletal structures. In one context, the membrane-associated form of these proteins can reduce the activity of the epithelial sodium channel (ENaC), playing a role in sodium i...

[]

0

[ "PANTHER" ]

[ "PTHR15934" ]

[ "AKAP7_isoform_gamma" ]

[ 2510 ]

1

[]

0

[ "2vfk", "2vfl", "2vfy", "3j4q", "3j4r", "5jj2", "6hiv", "6hiw", "6hiy", "7ane", "7aor", "7pub" ]

12

[]

0

[]

0

null

[ "Aquifex aeolicus (strain VF5)", "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "marine sediment metagenome" ]

[ 1, 1, 2504, 4 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 5, 6 ]

4

true

Family

A-kinase anchor protein 7 isoform gamma

AKAP7_isoform_gamma

3

IPR052642

52,642

Coiled-coil and Forkhead-associated domain-containing protein

CC-FHA_domain

Family

1,849

true

false

This family of proteins includes coiled-coil domain-containing protein 27 (CCDC27) and Forkhead-associated domain-containing protein 1 (FHAD1). CCDC27 contains a single coiled-coil region located in the central portion of the sequence. CCDC27 is widely conserved across mammalian species and shows enriched expression in...

[]

0

[ "PANTHER" ]

[ "PTHR18853" ]

[ "CC-FHA_domain" ]

[ 1849 ]

1

[]

0

[]

0

[ "PUB00162506" ]

[ "38563001" ]

[ "Forkhead-associated phosphopeptide binding domain 1 (FHAD1) deficiency impaired murine sperm motility." ]

[ 2024 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1849 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 8, 3, 8 ]

5

true

Family

Coiled-coil and Forkhead-associated domain-containing protein

CC-FHA_domain

7

IPR052643

52,643

Endoplasmic reticulum resident protein 44

ERP44

Family

2,212

true

false

This family of proteins is involved in the regulation of the early secretory pathway by mediating thiol-dependent retention. They interact with substrate proteins through a conserved CRFS motif to form mixed disulfides. Additionally, these proteins can inhibit the calcium channel activity of ITPR1 and are implicated in...

[]

0

[ "PANTHER" ]

[ "PTHR46295" ]

[ "ERP44" ]

[ 2212 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-HSA-6798695", "R-MMU-6798695" ]

[ "REACTOME:R-BTA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695" ]

3

[ "2r2j", "5gu6", "5gu7", "5hqp", "5xwm" ]

5

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2212 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 3, 9, 2, 4 ]

6

true

Family

Endoplasmic reticulum resident protein 44

ERP44

1

IPR052644

52,644

Zinc finger matrin-type protein 3

ZMAT3

Family

2,263

true

false

This family of proteins includes members that are recognized as direct targets of the p53/TP53 tumor suppressor gene. They are implicated in the TP53-dependent regulatory pathway that influences cell growth. These proteins may also have a role in the induction of apoptosis, potentially through mechanisms involving the ...

[]

0

[ "PANTHER" ]

[ "PTHR46786" ]

[ "ZMAT3" ]

[ 2263 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2263 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 1, 4, 9, 3, 4, 4 ]

6

true

Family

Zinc finger matrin-type protein 3

ZMAT3

1

IPR052645

52,645

Pumilio domain-containing protein

Pumilio_domain_protein

Family

2,135

true

false

This family of proteins includes RNA-binding proteins that are involved in the post-transcriptional regulation of gene expression. They are known to interact with the 3'-UTR regions of specific mRNAs, influencing their stability and turnover. Members of this family predominantly target mRNAs encoding membrane-associate...

[]

0

[ "PANTHER" ]

[ "PTHR47093" ]

[ "Pumilio_domain_protein" ]

[ 2135 ]

1

[]

0

[ "6nww", "6nx5", "6ny5" ]

3

[]

0

[]

0

null

[ "Eukaryota", "Shewanella electrica" ]

[ 2134, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2 ]

3

true

Family

Pumilio domain-containing protein

Pumilio_domain_protein

5