interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052646 | 52,646 | Peroxisomal membrane PEX28-32 | Peroxisomal_PEX28-32 | Family | 2,046 | true | false | This family of proteins is involved in the biogenesis and maintenance of peroxisomes, which are key organelles in eukaryotic cells responsible for various metabolic processes including the beta-oxidation of fatty acids and the detoxification of hydrogen peroxide. Members of this family play a role in the regulation of ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31679"
] | [
"Peroxisomal_PEX28-32"
] | [
2046
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2046
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
3,
1
] | 3 | true | Family | Peroxisomal membrane PEX28-32 | Peroxisomal membrane PEX28-32 | Peroxisomal_PEX28-32 | 5 |
IPR052647 | 52,647 | Zinc finger CCCH-type domain-containing protein | Zinc_finger_CCCH-type | Family | 2,126 | true | false | This family of proteins contains a zinc finger CCCH-type motif, which is typically involved in RNA binding and can play a role in post-transcriptional regulation of gene expression. Members of this family may be involved in processes such as mRNA splicing, translation, and degradation, as well as in the regulation of m... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46582"
] | [
"Zinc_finger_CCCH-type"
] | [
2126
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9930044",
"R-MMU-9930044",
"R-RNO-9930044"
] | [
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-9930044",
"REACTOME:R-RNO-9930044"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2126
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
24,
10,
5,
8
] | 5 | true | Family | Zinc finger CCCH-type domain-containing protein | Zinc finger CCCH-type domain-containing protein | Zinc_finger_CCCH-type | 8 |
IPR052648 | 52,648 | L-seryl-tRNA(Sec) kinase | Ser-tRNA(Sec)_kinase | Family | 1,814 | true | false | This family of proteins is involved in the biosynthesis of selenocysteine, an essential amino acid in some organisms. Members of this family catalyze the phosphorylation of seryl-tRNA(Sec), converting it to O-phosphoseryl-tRNA(Sec). This reaction is a crucial step in the formation of selenocysteine, which is then incor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR20873"
] | [
"Ser-tRNA(Sec)_kinase"
] | [
1814
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"2.7.1.164",
"PWY-6281",
"R-HSA-2408557"
] | [
"EC:2.7.1.164",
"METACYC:PWY-6281",
"REACTOME:R-HSA-2408557"
] | 3 | [
"3a4l",
"3a4m",
"3a4n",
"3adb",
"3adc",
"3add",
"3am1"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
50,
124,
1634,
6
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
3,
4,
7
] | 6 | true | Family | L-seryl-tRNA(Sec) kinase | L-seryl-tRNA(Sec) kinase | Ser-tRNA(Sec)_kinase | 7 |
IPR052650 | 52,650 | Zinc finger CCCH domain-containing protein | Zinc_finger_CCCH | Family | 2,588 | true | false | This family of proteins includes zinc finger CCCH domain-containing proteins which are characterized by their zinc finger motifs. These motifs are typically involved in binding to RNA or DNA and are essential for various biological processes including transcriptional regulation. Members of this family, such as the FRIG... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36886"
] | [
"Zinc_finger_CCCH"
] | [
2588
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2588
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
13,
19
] | 3 | true | Family | Zinc finger CCCH domain-containing protein | Zinc finger CCCH domain-containing protein | Zinc_finger_CCCH | 7 |
IPR052651 | 52,651 | WD repeat-containing protein 81 | WDR81 | Family | 1,958 | true | false | The WD repeat WDR81 family proteins function as negative regulators of PI3 kinase/PI3K activity on endosomal membranes, influencing the phosphatidylinositol 3-phosphate content and thus affecting endosome dynamics including fusion, recycling, sorting, and transport. They are implicated in the lysosomal degradation path... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44662"
] | [
"WDR81"
] | [
1958
] | 1 | [
"REACTOME"
] | [
"R-HSA-9013148"
] | [
"REACTOME:R-HSA-9013148"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Klebsiella pneumoniae"
] | [
1957,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
10,
7,
3,
2,
6
] | 6 | true | Family | WD repeat-containing protein 81 | WD repeat-containing protein 81 | WDR81 | 4 |
IPR052652 | 52,652 | Telomerase Complex Component | Telomerase_Complex_Comp | Family | 1,667 | true | false | This family of proteins includes components of the telomerase ribonucleoprotein complex, which plays a crucial role in the replication of chromosome termini. Members are involved in the stabilization and localization of vault RNA within the ribonucleoprotein vault particle, a structure implicated in nucleo-cytoplasmic ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44791"
] | [
"Telomerase_Complex_Comp"
] | [
1667
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
154,
1449,
46,
6,
12
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
11,
4,
7
] | 4 | true | Family | Telomerase Complex Component | Telomerase Complex Component | Telomerase_Complex_Comp | 3 |
IPR052653 | 52,653 | ADP-ribosylation factor-binding | ARF-binding | Family | 1,866 | true | false | This family of proteins is involved in the regulation of membrane traffic, particularly through the trans-Golgi network. Members of this family are likely to interact with ADP-ribosylation factors, which are small GTP-binding proteins critical for vesicle formation and trafficking. The association with these factors su... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47180"
] | [
"ARF-binding"
] | [
1866
] | 1 | [] | [] | [] | 0 | [
"3mnm",
"5cn1",
"5cn2"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1866
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
2
] | 3 | true | Family | ADP-ribosylation factor-binding | ADP-ribosylation factor-binding | ARF-binding | 1 |
IPR052654 | 52,654 | Chondroitin Sulfate Sulfotransferase | CS_Sulfotransferase | Family | 2,096 | true | false | This family of proteins functions as sulfotransferases, catalyzing the transfer of sulfate groups from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to specific hydroxyl groups of chondroitin sulfate A. The main activity involves the formation of chondroitin sulfate E by sulfating the C-6 hydroxyl group of the GalNAc 4-... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15723"
] | [
"CS_Sulfotransferase"
] | [
2096
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.8.2.33",
"PWY-6567",
"PWY-6568",
"R-HSA-2022870",
"R-HSA-2022923",
"R-MMU-2022870",
"R-MMU-2022923",
"R-RNO-2022870",
"R-RNO-2022923"
] | [
"EC:2.8.2.33",
"METACYC:PWY-6567",
"METACYC:PWY-6568",
"REACTOME:R-HSA-2022870",
"REACTOME:R-HSA-2022923",
"REACTOME:R-MMU-2022870",
"REACTOME:R-MMU-2022923",
"REACTOME:R-RNO-2022870",
"REACTOME:R-RNO-2022923"
] | 9 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
2,
2092,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
2,
1,
5
] | 4 | true | Family | Chondroitin Sulfate Sulfotransferase | Chondroitin Sulfate Sulfotransferase | CS_Sulfotransferase | 6 |
IPR052656 | 52,656 | Chromatin target of PRMT1 | CTOP_PRMT1 | Family | 1,716 | true | true | The Chromatin Target of PRMT1 (CTOP) protein family is involved in various cellular processes, including mRNA nuclear export, estrogen receptor target gene activation, and gene transcription regulation [ , , ]. Members of this family are components of the TREX complex, which is crucial for mRNA transcription, processin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48426"
] | [
""
] | [
1716
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-159236",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU-159236",
"R-MMU-72187",
"R-MMU-73856",
"R-RNO-159236",
"R-RNO-72187",
"R-RNO-73856"
] | [
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-73856",
"REACTOME:R-RNO-159236",
"REACTOME:R-RNO-72187",
"REACTOME:R-RNO-73856"
] | 9 | [] | 0 | [
"PUB00057915",
"PUB00155236",
"PUB00155237",
"PUB00155238"
] | [
"19858291",
"20688955",
"23299939",
"25284789"
] | [
"Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.",
"Fetal globin expression is regulated by Friend of Prmt1.",
"Chtop is a component of the dynamic TREX mRNA export complex.",
"5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methyl... | [
2010,
2010,
2013,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1716
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
7,
9
] | 4 | true | Family | Chromatin target of PRMT1 | Chromatin target of PRMT1 | CTOP_PRMT1 | 7 |
IPR052657 | 52,657 | Arabidopsis PWWP domain-containing | PDP_family_Arabidopsis | Family | 2,191 | true | false | The PDP family is involved in the regulation of gene expression through interaction with the PRC2 complex and modulation of the H3K27me3 level. Members of the PDP family, such as PDP1, PDP2, PDP3, and PDP6, are known to interact with MSI4/FVE and MSI5, which leads to the suppression of FLC, MAF4, and MAF5 expression. T... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10688"
] | [
"PDP_family_Arabidopsis"
] | [
2191
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2191
] | 1 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
29,
2,
5,
14
] | 4 | true | Family | Arabidopsis PWWP domain-containing | Arabidopsis PWWP domain-containing | PDP_family_Arabidopsis | 1 |
IPR052658 | 52,658 | Tetratricopeptide repeat-containing protein | TPR-containing | Family | 1,746 | true | false | This family of proteins contains tetratricopeptide repeat (TPR) motifs, which are known to mediate protein-protein interactions. These motifs typically consist of 34 amino acids and form a helical structure that facilitates the assembly of multiprotein complexes. The proteins in this family are likely involved in vario... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15544"
] | [
"TPR-containing"
] | [
1746
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
71,
1675
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
5,
3,
4,
5,
3
] | 7 | true | Family | Tetratricopeptide repeat-containing protein | Tetratricopeptide repeat-containing protein | TPR-containing | 8 |
IPR052659 | 52,659 | Nectin and Poliovirus Receptor | Nectin/PVR | Family | 1,586 | true | false | The Nectin family proteins are involved in modulating T-cell signaling and can act as either costimulators or coinhibitors of T-cell function, depending on their receptor interactions. They play a crucial role in immune response by stimulating T-cell proliferation and cytokine production when binding to CD226, or inhib... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47387"
] | [
"Nectin/PVR"
] | [
1586
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-418990",
"R-HSA-420597",
"R-MMU-198933",
"R-MMU-418990",
"R-MMU-420597"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-418990",
"REACTOME:R-HSA-420597",
"REACTOME:R-MMU-198933",
"REACTOME:R-MMU-418990",
"REACTOME:R-MMU-420597"
] | 6 | [
"1dgi",
"1nn8",
"3epc",
"3epd",
"3epf",
"3j8f",
"3j9f",
"3r0n",
"3udw",
"3uro",
"4dfh",
"4dfi",
"4fmk",
"4fn0",
"4fqp",
"4fs0",
"4hza",
"5v52",
"6arq",
"6isc",
"6o3o",
"8x6b",
"9e6y"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1586
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
16,
9,
9
] | 4 | true | Family | Nectin and Poliovirus Receptor | Nectin and Poliovirus Receptor | Nectin/PVR | 3 |
IPR052663 | 52,663 | Release factor glutamine methyltransferase, cyanobacteria-type | RF_glutamine_MTase_cyano | Family | 1,135 | true | true | This family of proteins includes Release factor glutamine methyltransferases (PRMC) mainly from cyanobacteria and uncharacterised plant sequences. PRMC is involved in the post-translational modification of class 1 translation termination release factors. Specifically, these enzymes catalyse the methylation of the gluta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47441"
] | [
"RF_glutamine_MTase"
] | [
1135
] | 1 | [
"EC"
] | [
"2.1.1.297"
] | [
"EC:2.1.1.297"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR004556"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
373,
762
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
3,
4
] | 3 | true | Family | Release factor glutamine methyltransferase, cyanobacteria-type | Release factor glutamine methyltransferase, cyanobacteria-type | RF_glutamine_MTase_cyano | 9 |
IPR052664 | 52,664 | BTB and MATH domain-containing protein | BTB-MATH_domain_protein | Family | 1,605 | true | false | This family of proteins includes members that contain both BTB (Broad-Complex, Tramtrack and Bric a brac) and MATH (Meprin and TRAF Homology) domains. These domains suggest a role in protein-protein interactions, where the BTB domain is involved in the assembly of multimeric protein complexes, and the MATH domain is im... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22743"
] | [
"BTB-MATH_domain_protein"
] | [
1605
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1605
] | 1 | [
"Caenorhabditis elegans"
] | [
44
] | 1 | true | Family | BTB and MATH domain-containing protein | BTB and MATH domain-containing protein | BTB-MATH_domain_protein | 8 |
IPR052665 | 52,665 | Neuropeptide-activated GPCR | Neuropeptide-GPCR | Family | 1,624 | true | false | This family of proteins includes G-protein coupled receptors (GPCRs) that are involved in various signaling pathways. Members of this family are characterized by their ability to interact with G proteins and initiate intracellular second messenger cascades, typically involving phosphatidylinositol-calcium or cAMP. Spec... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24224"
] | [
"Neuropeptide-GPCR"
] | [
1624
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Micavibrio aeruginosavorus"
] | [
1623,
1
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
25,
6
] | 2 | true | Family | Neuropeptide-activated GPCR | Neuropeptide-activated GPCR | Neuropeptide-GPCR | 4 |
IPR052666 | 52,666 | Cytochrome P450 20A1-like | CYP450_20A1-like | Family | 1,471 | true | false | This family of proteins includes members that are part of the cytochrome P450 superfamily, which are heme-thiolate proteins. These enzymes are involved in the metabolism of a wide variety of substrates, including xenobiotics, steroids, fatty acids, and drugs. They function primarily in the liver and are responsible for... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24280"
] | [
"CYP450_20A1-like"
] | [
1471
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Opisthokonta"
] | [
2,
1469
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
3,
5
] | 4 | true | Family | Cytochrome P450 20A1-like | Cytochrome P450 20A1-like | CYP450_20A1-like | 6 |
IPR052667 | 52,667 | E3 ubiquitin-protein ligase RING-type | E3_ubiquitin-ligase_RING | Family | 1,720 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that are involved in the ubiquitination process. Members of this family catalyze the attachment of ubiquitin to substrate proteins, typically through 'Lys-48'-linked polyubiquitination, which targets the substrates for proteasomal degradation. This process i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47156"
] | [
"E3_ubiquitin-ligase_RING"
] | [
1720
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1660514",
"R-CEL-199992",
"R-CEL-432720",
"R-CEL-432722",
"R-CEL-6807878",
"R-CEL-6811434"
] | [
"REACTOME:R-CEL-1660514",
"REACTOME:R-CEL-199992",
"REACTOME:R-CEL-432720",
"REACTOME:R-CEL-432722",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811434"
] | 6 | [
"5vzv",
"5vzw"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Harvfovirus sp.",
"viral metagenome"
] | [
2,
1716,
1,
1
] | 4 | [
"Caenorhabditis elegans",
"Homo sapiens",
"Rattus norvegicus"
] | [
46,
1,
2
] | 3 | true | Family | E3 ubiquitin-protein ligase RING-type | E3 ubiquitin-protein ligase RING-type | E3_ubiquitin-ligase_RING | 6 |
IPR052669 | 52,669 | SL1/TIF-IB Complex Component | SL1/TIF-IB_Component | Family | 1,314 | true | false | This family of proteins includes components of the SL1/TIF-IB complex, which plays a crucial role in the initiation of RNA polymerase I-dependent transcription. These proteins are key in the formation of the pre-initiation complex (PIC) by associating with the rDNA promoter, a process that is essential for the transcri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32122"
] | [
"SL1/TIF-IB_Component"
] | [
1314
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5250924",
"R-CEL-73772",
"R-HSA-427359",
"R-HSA-427413",
"R-HSA-5250924",
"R-HSA-73762",
"R-HSA-73772",
"R-HSA-73863",
"R-MMU-5250924",
"R-MMU-73762",
"R-MMU-73772",
"R-MMU-73863",
"R-RNO-5250924",
"R-RNO-73762",
"R-RNO-73772",
"R-RNO-73863"
] | [
"REACTOME:R-CEL-5250924",
"REACTOME:R-CEL-73772",
"REACTOME:R-HSA-427359",
"REACTOME:R-HSA-427413",
"REACTOME:R-HSA-5250924",
"REACTOME:R-HSA-73762",
"REACTOME:R-HSA-73772",
"REACTOME:R-HSA-73863",
"REACTOME:R-MMU-5250924",
"REACTOME:R-MMU-73762",
"REACTOME:R-MMU-73772",
"REACTOME:R-MMU-73863"... | 16 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1314
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
4,
4,
3
] | 5 | true | Family | SL1/TIF-IB Complex Component | SL1/TIF-IB Complex Component | SL1/TIF-IB_Component | 9 |
IPR052670 | 52,670 | UPF0654 domain-containing protein | UPF0654_domain | Family | 1,353 | true | false | This family of proteins may be involved in the protection of dormant spores from desiccation and could play a role in the formation or survival of specific fungal reproductive structures such as microconidia and ascospores. Members of this family are characterized by a shared domain, indicating a potential commonality ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36576"
] | [
"UPF0654_domain"
] | [
1353
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1353
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3
] | 2 | true | Family | UPF0654 domain-containing protein | UPF0654 domain-containing protein | UPF0654_domain | 9 |
IPR052671 | 52,671 | Acrosomal SP-10-like | Acrosomal_SP-10-like | Family | 1,384 | true | false | This family of proteins is involved in the reproductive process, specifically within the acrosome reaction of sperm cells. Acrosomal proteins are known to play a role in the binding and penetration of the sperm into the egg during fertilization. They are typically associated with the acrosome, an organelle that caps th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR17571"
] | [
"Acrosomal_SP-10-like"
] | [
1384
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
309,
1068,
4,
3
] | 4 | [
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
3
] | 4 | true | Family | Acrosomal SP-10-like | Acrosomal SP-10-like | Acrosomal_SP-10-like | 3 |
IPR052672 | 52,672 | Type I Cytokine Receptor Family, Type 2 Subfamily | Type1_Cytokine_Rcpt_Type2 | Family | 5,902 | true | false | The Type I Cytokine Receptor family, Type 2 subfamily, includes receptors that play crucial roles in immune system regulation and defense mechanisms. Members of this family are receptors for interleukins, such as IL27 and IL23, and mediate signal transduction through the Jak-Stat signaling pathway. They are involved in... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48423"
] | [
""
] | [
5902
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-449836",
"R-HSA-6785807",
"R-HSA-6788467",
"R-HSA-8984722",
"R-HSA-9020591",
"R-HSA-9020933",
"R-HSA-9020956",
"R-HSA-9616222",
"R-HSA-9674555",
"R-HSA-9705462",
"R-MMU-6788467",
"R-MMU-8984722",
"R-MMU-9020591",
"R-MMU-9020933",
"R-MMU-9020956",
"R-RNO-6788467"
] | [
"REACTOME:R-HSA-449836",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-6788467",
"REACTOME:R-HSA-8984722",
"REACTOME:R-HSA-9020591",
"REACTOME:R-HSA-9020933",
"REACTOME:R-HSA-9020956",
"REACTOME:R-HSA-9616222",
"REACTOME:R-HSA-9674555",
"REACTOME:R-HSA-9705462",
"REACTOME:R-MMU-6788467",
"REACTOME... | 16 | [
"3l5h",
"3l5i",
"3l5j",
"5mzv",
"6wdq",
"7u7n",
"7z0l",
"7zg0",
"8d6a",
"8d74",
"8d7r",
"8d85",
"8dpt",
"8v29",
"8v2a",
"8v2b",
"8v2c",
"9mfg"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
5902
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
39,
17,
17
] | 4 | true | Family | Type I Cytokine Receptor Family, Type 2 Subfamily | Type I Cytokine Receptor Family, Type 2 Subfamily | Type1_Cytokine_Rcpt_Type2 | 2 |
IPR052673 | 52,673 | Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, CfbD | Ni-siroh_cyclase_CfbD | Family | 671 | true | false | The NifD/NifK/NifE/NifN family is involved in the biosynthesis of coenzyme F430, essential for methanogenesis and anaerobic methane oxidation. Members catalyze the reduction and gamma-lactamization of Ni-sirohydrochlorin a,c-diamide, producing seco-F430, a precursor to coenzyme F430. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42846"
] | [
"Ni-siroh_cyclase_CfbD"
] | [
671
] | 1 | [
"EC",
"METACYC"
] | [
"6.3.3.7",
"PWY-5196"
] | [
"EC:6.3.3.7",
"METACYC:PWY-5196"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
248,
413,
10
] | 3 | [] | [] | 0 | true | Family | Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, CfbD | Ni-sirohydrochlorin a,c-diamide reductive cyclase complex, CfbD | Ni-siroh_cyclase_CfbD | 6 |
IPR052674 | 52,674 | Selenoprotein SelWTH-like | SelWTH-like | Family | 1,324 | true | false | This family of proteins may play a role in redox processes, which are chemical reactions involving the transfer of electrons. These reactions are fundamental to numerous metabolic pathways and cellular functions, including the detoxification of harmful compounds, the synthesis of certain biomolecules, and the regulatio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33638"
] | [
"SelWTH-like"
] | [
1324
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1324
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
3,
2,
3,
4,
1,
6
] | 8 | true | Family | Selenoprotein SelWTH-like | Selenoprotein SelWTH-like | SelWTH-like | 2 |
IPR052675 | 52,675 | Zinc finger translocation-associated & Spindlin interactor | ZnF_transloc-Spindlin_int | Family | 1,033 | true | false | The Zinc finger translocation-associated and Spindlin interactor and repressor of chromatin-binding protein family is involved in the regulation of gene expression and response to DNA damage. Members of the family negatively regulate the transcriptional activator activity of SPIN proteins by inhibiting their ability to... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34589"
] | [
"ZnF_transloc-Spindlin_int"
] | [
1033
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1033
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
4,
6,
6
] | 4 | true | Family | Zinc finger translocation-associated & Spindlin interactor | Zinc finger translocation-associated & Spindlin interactor | ZnF_transloc-Spindlin_int | 3 |
IPR052676 | 52,676 | Zinc-sensing G-protein coupled receptor | Zinc-sensing_GPCR | Family | 939 | true | false | This family of proteins functions as zinc-sensing receptors that detect changes in extracellular zinc ion concentrations. They are involved in transmitting zinc signals and play a role in various physiological processes, including the regulation of glucose homeostasis, gastrointestinal mobility, hormone secretion, and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46752"
] | [
"Zinc-sensing_GPCR"
] | [
939
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-373076",
"R-HSA-416476",
"R-HSA-418555",
"R-MMU-373076",
"R-MMU-416476",
"R-MMU-418555"
] | [
"REACTOME:R-HSA-373076",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-373076",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-418555"
] | 6 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
939
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
4,
3
] | 4 | true | Family | Zinc-sensing G-protein coupled receptor | Zinc-sensing G-protein coupled receptor | Zinc-sensing_GPCR | 8 |
IPR052677 | 52,677 | Dinucleoside polyphosphate hydrolase | Dinucleoside_ppp_hydrolase | Family | 914 | true | false | This family of proteins exhibits a multifaceted enzymatic activity, including the hydrolysis of dinucleoside polyphosphates such as Ap3A and Ap4A into AMP and ADP or ADP and AMP, respectively. They also show adenylylsulfatase activity, converting adenosine 5'-phosphosulfate into AMP and sulfate, and adenosine 5'-monoph... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46981"
] | [
"Dinucleoside_ppp_hydrolase"
] | [
914
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC"
] | [
"2.7.7.51",
"3.6.1.29",
"3.6.2.1",
"3.9.1.-",
"PWY-6794"
] | [
"EC:2.7.7.51",
"EC:3.6.1.29",
"EC:3.6.2.1",
"EC:3.9.1.-",
"METACYC:PWY-6794"
] | 5 | [
"1fhi",
"1fit",
"2fhi",
"2fit",
"3fit",
"4fit",
"5fit",
"6fit",
"7p8p"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinopolymorpha",
"Eukaryota"
] | [
4,
910
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
5,
6
] | 4 | true | Family | Dinucleoside polyphosphate hydrolase | Dinucleoside polyphosphate hydrolase | Dinucleoside_ppp_hydrolase | 1 |
IPR052678 | 52,678 | Organic solute transporter beta subunit | OST-beta_subunit | Family | 947 | true | false | This family of proteins includes essential components of the Ost-alpha/Ost-beta complex, which functions as a heterodimeric intestinal basolateral transporter. These proteins are responsible for the export of bile acids from enterocytes into portal blood, with a higher efficiency for transporting taurine-conjugated bil... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36129"
] | [
"OST-beta_subunit"
] | [
947
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-159418",
"R-HSA-159418",
"R-MMU-159418"
] | [
"REACTOME:R-BTA-159418",
"REACTOME:R-HSA-159418",
"REACTOME:R-MMU-159418"
] | 3 | [
"1dqg",
"1dqo",
"1fwu",
"1fwv"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
944
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
1,
1,
2
] | 4 | true | Family | Organic solute transporter beta subunit | Organic solute transporter beta subunit | OST-beta_subunit | 9 |
IPR052679 | 52,679 | Cell Proliferation Regulator | Cell_Prolif_Regulator | Family | 909 | true | false | This family of proteins is implicated in cellular growth processes, with a potential role in the regulation of cell proliferation. The members of this family are conserved across various species, suggesting a fundamental biological function related to cell division and growth regulation. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35079"
] | [
"Cell_Prolif_Regulator"
] | [
909
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
909
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
5,
36,
8
] | 4 | true | Family | Cell Proliferation Regulator | Cell Proliferation Regulator | Cell_Prolif_Regulator | 8 |
IPR052680 | 52,680 | Glycoprotein Hormones Alpha Subunit | Glyco_Hormone_Alpha | Family | 800 | true | false | This family of proteins functions as heterodimeric glycoprotein hormones that are involved in the regulation of thyroid cell metabolism. Members of this family can bind and activate the thyroid-stimulating hormone receptor (TSHR), which leads to an increase in cyclic AMP (cAMP) production. This signaling pathway is cru... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31129"
] | [
"Glyco_Hormone_Alpha"
] | [
800
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375281",
"R-HSA-418555",
"R-MMU-375281",
"R-MMU-418555",
"R-RNO-375281"
] | [
"REACTOME:R-HSA-375281",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-375281",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-375281"
] | 5 | [
"8enb",
"8end",
"8enf"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
800
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2,
3,
2,
2
] | 6 | true | Family | Glycoprotein Hormones Alpha Subunit | Glycoprotein Hormones Alpha Subunit | Glyco_Hormone_Alpha | 6 |
IPR052681 | 52,681 | CRISPR-associated Cas7/Cst2/DevR | CRISPR-Cas7/Cst2/DevR | Family | 296 | true | false | This family of proteins is involved in the CRISPR adaptive immune system, which provides defense mechanisms against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Members of this family are associated with the processing of CRISPR clusters into CRISPR RNA (crRNA), which contai... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37459"
] | [
"CRISPR-Cas7/Cst2/DevR"
] | [
296
] | 1 | [] | [] | [] | 0 | [
"3ps0",
"4reg",
"7r21",
"7r2k",
"7tr6",
"7tr8",
"7tr9",
"7tra",
"9cp1",
"9cp2",
"9cp3",
"9cro",
"9crp",
"9crq"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria"
] | [
183,
113
] | 2 | [] | [] | 0 | true | Family | CRISPR-associated Cas7/Cst2/DevR | CRISPR-associated Cas7/Cst2/DevR | CRISPR-Cas7/Cst2/DevR | 5 |
IPR052682 | 52,682 | Marginal zone B- and B1-cell-specific protein | MZB1 | Family | 707 | true | false | This family of proteins is involved in the immune response by associating with immunoglobulin M (IgM) heavy and light chains to promote IgM assembly and secretion. They may function as molecular chaperones or oxidoreductases, given their low level of oxidoreductase activity. These proteins play a role in diversifying p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15881"
] | [
"MZB1"
] | [
707
] | 1 | [] | [] | [] | 0 | [
"7aah"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
707
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
3
] | 3 | true | Family | Marginal zone B- and B1-cell-specific protein | Marginal zone B- and B1-cell-specific protein | MZB1 | 5 |
IPR052684 | 52,684 | Podoplanin domain-containing protein | Podoplanin_domain | Family | 693 | true | false | This family of proteins mediates various cellular processes including cell migration, adhesion, and morphological changes. They play a crucial role in the separation of blood and lymphatic vessels during development by interacting with CLEC1B, which leads to platelet activation. They also modulate platelet aggregation ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47390"
] | [
"Podoplanin_domain"
] | [
693
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-114604",
"R-HSA-114604",
"R-HSA-9827857",
"R-MMU-114604",
"R-RNO-114604"
] | [
"REACTOME:R-CFA-114604",
"REACTOME:R-HSA-114604",
"REACTOME:R-HSA-9827857",
"REACTOME:R-MMU-114604",
"REACTOME:R-RNO-114604"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
693
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2,
7
] | 4 | true | Family | Podoplanin domain-containing protein | Podoplanin domain-containing protein | Podoplanin_domain | 8 |
IPR052685 | 52,685 | Apoptosis Repressor CARD Domain-Containing Protein | Apoptosis_Repressor_CARD | Family | 578 | true | false | This family of proteins functions as apoptosis repressors, playing a critical role in blocking multiple modes of cell death. They inhibit both extrinsic and intrinsic apoptotic pathways by interacting with key components such as FAS, FADD, CASP8, and BAX. These interactions prevent the assembly of death-inducing signal... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22797"
] | [
"Apoptosis_Repressor_CARD"
] | [
578
] | 1 | [] | [] | [] | 0 | [
"4uz0"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
578
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
7,
9
] | 3 | true | Family | Apoptosis Repressor CARD Domain-Containing Protein | Apoptosis Repressor CARD Domain-Containing Protein | Apoptosis_Repressor_CARD | 6 |
IPR052686 | 52,686 | Cancer-associated gene 1 homolog | CAGE1_homolog | Family | 477 | true | false | This family of proteins is associated with cancer-related processes. Members of this family are homologous and share a common function in cellular mechanisms that may contribute to the development or progression of cancer. The exact molecular function and biological role of these proteins remain to be fully elucidated,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36864"
] | [
"CAGE1_homolog"
] | [
477
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
477
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4
] | 3 | true | Family | Cancer-associated gene 1 homolog | Cancer-associated gene 1 homolog | CAGE1_homolog | 8 |
IPR052687 | 52,687 | Succinate Dehydrogenase Assembly Factor 1 | SDHAF1 | Family | 478 | true | false | The SDHAF1 subfamily is involved in the assembly of succinate dehydrogenase (SDH), a key enzyme complex in both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain. It facilitates the oxidation of succinate to fumarate and the reduction of ubiquinone to ubiquinol. The family plays a crucia... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47046"
] | [
"SDHAF1"
] | [
478
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9854311",
"R-HSA-9854311",
"R-MMU-9854311"
] | [
"REACTOME:R-BTA-9854311",
"REACTOME:R-HSA-9854311",
"REACTOME:R-MMU-9854311"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
478
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
1
] | 4 | true | Family | Succinate Dehydrogenase Assembly Factor 1 | Succinate Dehydrogenase Assembly Factor 1 | SDHAF1 | 2 |
IPR052688 | 52,688 | Gamma-glutamyltransferase | Gamma-glutamyltransfase | Family | 401 | true | false | The gamma-glutamyltransferase family is characterized by its enzymatic ability to hydrolyze and transfer gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to various acceptors. The enzymatic activity of the family members is crucial for the metabolism of glutathione, which plays a significant ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47278"
] | [
"Gamma-glutamyltransfase"
] | [
401
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.2",
"3.4.19.13",
"PWY-4041",
"PWY-4061",
"PWY-5826",
"PWY-6842",
"PWY-7112",
"PWY-7559",
"PWY-8001",
"PWY-8301",
"PWY-8355",
"R-HSA-174403",
"R-HSA-5423646",
"R-HSA-9753281",
"R-MMU-174403",
"R-MMU-5423646",
"R-MMU-9753281",
"R-RNO-174403",
"R-RNO-5423646",
"R-RNO-975328... | [
"EC:2.3.2.2",
"EC:3.4.19.13",
"METACYC:PWY-4041",
"METACYC:PWY-4061",
"METACYC:PWY-5826",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7559",
"METACYC:PWY-8001",
"METACYC:PWY-8301",
"METACYC:PWY-8355",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-9753281",
"... | 20 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
401
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
2,
4
] | 4 | true | Family | Gamma-glutamyltransferase | Gamma-glutamyltransferase | Gamma-glutamyltransfase | 5 |
IPR052690 | 52,690 | Antho-RFamide neuropeptide | Antho-RFamide | Family | 519 | true | false | This family of proteins includes Antho-RFamide neuropeptides which are likely transcriptional transactivators and potential neuromuscular transmitters. They share similarity to the FARP (FMRFamide related peptide) family, suggesting a role in neuronal signaling or modulation. One member is known to bind DNA at the tran... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31709"
] | [
"Trans_Neuromod_Peptide-like"
] | [
519
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nucleocytoviricota sp.",
"metagenomes"
] | [
19,
497,
1,
2
] | 4 | [
"Mus musculus",
"Rattus norvegicus"
] | [
20,
3
] | 2 | true | Family | Antho-RFamide neuropeptide | Antho-RFamide neuropeptide | Antho-RFamide | 3 |
IPR052692 | 52,692 | DVL/RTFL small polypeptides | DVL_RTFL_polypeptides | Family | 451 | true | false | The DVL/RTFL small polypeptides family comprises regulatory molecules that play a crucial role in coordinating cellular responses essential for plant differentiation, growth, and development. Members of the family are involved in restricting polar cell proliferation within lateral organs and orchestrating the recruitme... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47596"
] | [
"DVL_RTFL_polypeptides"
] | [
451
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
451
] | 1 | [
"Arabidopsis thaliana"
] | [
11
] | 1 | true | Family | DVL/RTFL small polypeptides | DVL/RTFL small polypeptides | DVL_RTFL_polypeptides | 1 |
IPR052693 | 52,693 | Yeast Multidrug Resistance Regulatory Proteins | Yeast_MDR_Regulatory | Family | 223 | true | false | This family of proteins includes zinc finger transcription factors and other regulatory proteins involved in the control of gene expression related to multidrug resistance. Members of this family are known to regulate the transcription of various genes, including those encoding ATP-binding cassette (ABC) transporters, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31405"
] | [
"Yeast_MDR_Regulatory"
] | [
223
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
223
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
4
] | 1 | true | Family | Yeast Multidrug Resistance Regulatory Proteins | Yeast Multidrug Resistance Regulatory Proteins | Yeast_MDR_Regulatory | 5 |
IPR052695 | 52,695 | Kinetoplast-associated DNA-binding | Kinetoplast-DNA-binding | Family | 217 | true | false | This family of proteins includes histone H1-like DNA-binding proteins that are involved in the organization and segregation of kinetoplast DNA (kDNA), a unique mitochondrial DNA structure found in kinetoplastid protozoa. These proteins bind to specific fragments of minicircle DNA and play a crucial role in maintaining ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37564"
] | [
"Kinetoplast-DNA-binding"
] | [
217
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
216,
1
] | 2 | [] | [] | 0 | true | Family | Kinetoplast-associated DNA-binding | Kinetoplast-associated DNA-binding | Kinetoplast-DNA-binding | 7 |
IPR052696 | 52,696 | Coiled-coil domain-containing protein | Coiled-coil_domain | Family | 185 | true | false | This family of proteins contains a coiled-coil domain, which suggests that they may be involved in facilitating protein-protein interactions. The presence of a glutamate-rich region indicates a potential for interactions with other proteins or nucleic acids, possibly through electrostatic interactions. These features a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37337"
] | [
"Coiled-coil_domain"
] | [
185
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
185
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Family | Coiled-coil domain-containing protein | Coiled-coil domain-containing protein | Coiled-coil_domain | 8 |
IPR052697 | 52,697 | FNIP repeat-containing protein | FNIP_repeat | Family | 168 | true | false | This family of proteins contains FNIP repeats, which are typically involved in protein-protein interactions. Members of this family may play roles in various cellular processes, including signal transduction, cell adhesion, and the regulation of transcription and translation. The FNIP repeat is a structural motif that ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32031"
] | [
"FNIP_repeat"
] | [
168
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Megamimivirinae"
] | [
160,
8
] | 2 | [] | [] | 0 | true | Family | FNIP repeat-containing protein | FNIP repeat-containing protein | FNIP_repeat | 1 |
IPR052698 | 52,698 | Molybdenum Cofactor Utilization and Processing | MoCofactor_Util/Proc | Family | 25,434 | true | false | The protein family in question is involved in the utilization and processing of the molybdenum cofactor, a critical component for the activity of various enzymes. Members of the family have functions that include oxidizing purines such as hypoxanthine and xanthine to uric acid, and acting as chaperones for the insertio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30388"
] | [
"MoCofactor_Util/Proc"
] | [
25434
] | 1 | [] | [] | [] | 0 | [
"2we7",
"2we8",
"3on5"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
381,
24555,
34,
464
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Molybdenum Cofactor Utilization and Processing | Molybdenum Cofactor Utilization and Processing | MoCofactor_Util/Proc | 5 |
IPR052701 | 52,701 | Glycosaminoglycan & Ulvan Degrading Sulfatases | GAG_Ulvan_Degrading_Sulfatases | Family | 16,718 | true | false | The sulfatase family is involved in the degradation of various sulfated polysaccharides. Members of this family include enzymes that play a crucial role in the breakdown of glycosaminoglycans such as chondroitin sulfate and dermatan sulfate, by hydrolyzing the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43751"
] | [
"GAG_Ulvan_Degrading_Sulfatases"
] | [
16718
] | 1 | [] | [] | [] | 0 | [
"6s20",
"7an1",
"7ana",
"7anb",
"7oqd",
"7ozc",
"7oze",
"7p26",
"9bas",
"9bau",
"9bav"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Tetraselmis virus 1",
"unclassified sequences"
] | [
933,
12957,
2419,
1,
408
] | 5 | [
"Caenorhabditis elegans",
"Homo sapiens"
] | [
2,
1
] | 2 | true | Family | Glycosaminoglycan & Ulvan Degrading Sulfatases | Glycosaminoglycan & Ulvan Degrading Sulfatases | GAG_Ulvan_Degrading_Sulfatases | 3 |
IPR052702 | 52,702 | Mechanosensitive channel MscS-like | MscS-like_channel | Family | 18,163 | true | false | This family of proteins includes mechanosensitive channels that respond to changes in membrane tension and specific ionic conditions. Members of this family are involved in the regulation of osmotic pressure within cells, although not all have a major role in this process. They can form ion channels with varying conduc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30347"
] | [
"MscS-like_channel"
] | [
18163
] | 1 | [] | [] | [] | 0 | [
"7uw5",
"7ux1"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
20,
17940,
26,
177
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Mechanosensitive channel MscS-like | Mechanosensitive channel MscS-like | MscS-like_channel | 9 |
IPR052703 | 52,703 | Aromatic CoA oxygenase/epoxidase components | Aromatic_CoA_ox/epox | Family | 16,174 | true | false | This family of proteins includes components of multicomponent enzyme systems that catalyze the oxygenation and epoxidation of CoA-thioester substrates. Members of this family are involved in the aerobic biodegradation of aromatic compounds, playing a role in the ring-cleavage step of the degradation pathway. They funct... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30458"
] | [
"Aromatic_CoA_ox/epox"
] | [
16174
] | 1 | [] | [] | [] | 0 | [
"1otk",
"3per",
"3pf7",
"3pm5",
"3pvr",
"3pvt",
"3pvy",
"3pw1",
"3pw8",
"3pwq",
"3q1g",
"4ii4",
"4iit",
"4mud"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
450,
15555,
14,
155
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Aromatic CoA oxygenase/epoxidase components | Aromatic CoA oxygenase/epoxidase components | Aromatic_CoA_ox/epox | 9 |
IPR052704 | 52,704 | ECF Sigma-70 Factor Domain-Containing Protein | ECF_Sigma-70_Domain | Family | 23,421 | true | false | This family of proteins includes extracytoplasmic function (ECF) sigma factors that are involved in the initiation of RNA transcription. They promote the attachment of RNA polymerase to specific promoter DNA sites, facilitating the opening of the DNA double helix and the formation of the transcription bubble. These pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30173"
] | [
"ECF_Sigma-70_Domain"
] | [
23421
] | 1 | [] | [] | [] | 0 | [
"5xe7"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
23391,
10,
20
] | 3 | [] | [] | 0 | true | Family | ECF Sigma-70 Factor Domain-Containing Protein | ECF Sigma-70 Factor Domain-Containing Protein | ECF_Sigma-70_Domain | 9 |
IPR052705 | 52,705 | Gliding Motility-Regulating GTPase | Gliding_Motility_GTPase | Family | 17,913 | true | false | This family of proteins includes members that are involved in gliding motility mechanisms in certain bacterial species. Specifically, one member is known to be essential for multicellular development and for coordinating different types of gliding motility, which are critical for bacterial movement on surfaces. The pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42708"
] | [
"Gliding_Motility_GTPase"
] | [
17913
] | 1 | [] | [] | [] | 0 | [
"3t12",
"3t1o",
"3t1q",
"3t1t",
"3t1v",
"5ymx",
"6h17",
"6h35",
"6h5b",
"6hjh",
"6hjo",
"6izw"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
181,
17608,
4,
120
] | 4 | [] | [] | 0 | true | Family | Gliding Motility-Regulating GTPase | Gliding Motility-Regulating GTPase | Gliding_Motility_GTPase | 2 |
IPR052706 | 52,706 | Membrane-associated Transporter-like | Membrane-Transporter-like | Family | 18,232 | true | false | This family of proteins includes members that are involved in transport across cellular membranes, particularly for sulfate ions. One characterized member is suggested to belong to the SLC26A/SulP transporter family, which is known for mediating the exchange of anions across the membrane. The functions of the other mem... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43310"
] | [
"Membrane-Transporter-like"
] | [
18232
] | 1 | [] | [] | [] | 0 | [
"5da0",
"5iof"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Sym plasmid",
"Viruses",
"metagenomes"
] | [
14101,
3946,
47,
1,
2,
135
] | 6 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Membrane-associated Transporter-like | Membrane-associated Transporter-like | Membrane-Transporter-like | 7 |
IPR052707 | 52,707 | OsmC/Ohr Peroxiredoxin | OsmC_Ohr_Peroxiredoxin | Family | 16,735 | true | false | The OsmC/Ohr family proteins are involved in the detoxification of organic hydroperoxides, which are harmful by-products of oxidative stress. Members of this family exhibit a preference for metabolizing organic hydroperoxides rather than inorganic hydrogen peroxide. This activity is crucial for maintaining cellular red... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42830"
] | [
"OsmC_Ohr_Peroxiredoxin"
] | [
16735
] | 1 | [] | [] | [] | 0 | [
"1nye",
"1qwi",
"1ukk",
"2d7v",
"2onf"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
67,
16519,
22,
127
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | OsmC/Ohr Peroxiredoxin | OsmC/Ohr Peroxiredoxin | OsmC_Ohr_Peroxiredoxin | 2 |
IPR052708 | 52,708 | 5-oxoprolinase subunit C | PxpC | Family | 17,519 | true | false | The PxpC family proteins are enzymes that play a crucial role in the metabolic pathway of glutathione degradation. They catalyze the cleavage of 5-oxoproline (pyroglutamic acid) to form L-glutamate. This reaction is coupled with the hydrolysis of ATP to ADP and inorganic phosphate, which provides the necessary energy f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43309"
] | [
"PxpC"
] | [
17519
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.5.2.9",
"PWY-4041",
"PWY-7942"
] | [
"EC:3.5.2.9",
"METACYC:PWY-4041",
"METACYC:PWY-7942"
] | 3 | [
"3mml",
"5dud"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
85,
17155,
75,
204
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 5-oxoprolinase subunit C | 5-oxoprolinase subunit C | PxpC | 8 |
IPR052709 | 52,709 | Transposase-Methyltransferase Hybrid | Transposase-MT_Hybrid | Family | 30,888 | true | false | This family of proteins includes DNA-binding transposases and methyltransferases. Members of this family are involved in various DNA-related processes such as DNA double-strand break repair, stalled replication fork restart, and DNA integration. They exhibit a sequence-specific DNA-binding activity, recognizing specifi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46060"
] | [
"Transposase-MT_Hybrid"
] | [
30888
] | 1 | [] | [] | [] | 0 | [
"2f7t",
"3f2k",
"3hos",
"3hot",
"3k9j",
"3k9k",
"4mda",
"4mdb",
"4r79",
"4u7b",
"5hoo",
"7s03"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Saccharolobus",
"invertebrate metagenome"
] | [
6,
30873,
8,
1
] | 4 | [
"Homo sapiens"
] | [
11
] | 1 | true | Family | Transposase-Methyltransferase Hybrid | Transposase-Methyltransferase Hybrid | Transposase-MT_Hybrid | 7 |
IPR052710 | 52,710 | CAAX motif-specific protease | CAAX_protease | Family | 19,135 | true | false | This family of proteins is involved in post-translational modification processes, specifically in the proteolytic cleavage of farnesylated peptides containing the CAAX motif, where C is cysteine, A is an aliphatic amino acid, and X is any amino acid. Members of this family are implicated in the regulation of cellular p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36435"
] | [
"CAAX_protease"
] | [
19135
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"IncL/M plasmid R471a",
"Viruses",
"unclassified sequences"
] | [
1086,
17731,
117,
1,
3,
197
] | 6 | [] | [] | 0 | true | Family | CAAX motif-specific protease | CAAX motif-specific protease | CAAX_protease | 4 |
IPR052711 | 52,711 | Zinc-type Alcohol Dehydrogenase-like | Zinc_ADH-like | Family | 17,309 | true | false | This family of proteins includes zinc-type alcohol dehydrogenase-like enzymes that are part of the zinc-containing alcohol dehydrogenase family, specifically within the quinone oxidoreductase subfamily. Members of this family are involved in various metabolic processes, including the biosynthesis of complex organic mol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45033"
] | [
"Zinc_ADH-like"
] | [
17309
] | 1 | [] | [] | [] | 0 | [
"3uog",
"7vem",
"9mc1"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
44,
9406,
7746,
113
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
1
] | 2 | true | Family | Zinc-type Alcohol Dehydrogenase-like | Zinc-type Alcohol Dehydrogenase-like | Zinc_ADH-like | 8 |
IPR052712 | 52,712 | Acid resistance chaperone HdeD | Acid_resist_chaperone_HdeD | Family | 12,825 | true | false | This family of proteins includes HdeD, which is involved in the acid resistance system of bacteria. It functions by helping to maintain periplasmic pH under extremely acidic conditions, which is crucial for the survival of acid-sensitive proteins during acid stress. HdeD acts as a chaperone that binds to unfolded prote... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34989"
] | [
"Acid_resist_chaperone_HdeD"
] | [
12825
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
361,
12295,
66,
103
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Acid resistance chaperone HdeD | Acid resistance chaperone HdeD | Acid_resist_chaperone_HdeD | 6 |
IPR052713 | 52,713 | Fe(2+) transport protein A | FeoA | Family | 10,962 | true | false | This family of proteins is involved in the cellular uptake of ferrous ions (Fe(2+)). Members of this family facilitate the transport of Fe(2+) across the cell membrane, which is a critical process for cellular function and metabolism. Iron is an essential element for many biological processes, including oxygen transpor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42954"
] | [
"FeoA"
] | [
10962
] | 1 | [
"REACTOME"
] | [
"R-HSA-9638482"
] | [
"REACTOME:R-HSA-9638482"
] | 1 | [
"2gcx",
"2h3j",
"2k4y",
"2k5f",
"2k5i",
"2k5l",
"2lx9",
"3mhx",
"6e55",
"7r7b"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctYaH2",
"metagenomes"
] | [
146,
10659,
9,
1,
147
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Fe(2+) transport protein A | Fe(2+) transport protein A | FeoA | 7 |
IPR052716 | 52,716 | MOSC domain-containing protein | MOSC_domain | Family | 8,505 | true | false | This family of proteins is involved in the biosynthesis and coordination of metal-sulfur clusters and the reduction of N-oxygenated molecules. Members of this family are characterized by the presence of a MOSC domain, which is responsible for the tight coordination of the molybdenum cofactor within the core of the enzy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36930"
] | [
"MOSC_domain"
] | [
8505
] | 1 | [] | [] | [] | 0 | [
"1oru"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
299,
7522,
506,
3,
175
] | 5 | [
"Caenorhabditis elegans"
] | [
4
] | 1 | true | Family | MOSC domain-containing protein | MOSC domain-containing protein | MOSC_domain | 7 |
IPR052717 | 52,717 | Vacuolar processing and transposase activity regulators | Vacuolar_transposase_reg | Family | 4,063 | true | false | This family of proteins is involved in diverse cellular processes including vacuolar processing, morphology, transposase activity, and sumoylation. Members of this family are known to play roles in the regulation of transcription, cell proliferation, and may interact with viral elements during infection. Some proteins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46169"
] | [
"Vacuolar_transposase_reg"
] | [
4063
] | 1 | [
"REACTOME"
] | [
"R-HSA-4551638"
] | [
"REACTOME:R-HSA-4551638"
] | 1 | [
"2bw3",
"4d1q",
"6dww",
"6dwy",
"6dwz",
"6dx0",
"8edg",
"8sjd"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4063
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens"
] | [
4,
13,
6,
2
] | 4 | true | Family | Vacuolar processing and transposase activity regulators | Vacuolar processing and transposase activity regulators | Vacuolar_transposase_reg | 9 |
IPR052718 | 52,718 | NmrA-type domain-containing oxidoreductase | NmrA-type_oxidoreductase | Family | 14,053 | true | false | This family of proteins includes NmrA-type oxidoreductases involved in various redox reactions. Members of this family are implicated in the reduction of quinones and may have roles in redox sensing and regulation of growth. Additionally, some proteins in this family participate in complex biosynthetic pathways, such a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47129"
] | [
"NmrA-type_oxidoreductase"
] | [
14053
] | 1 | [] | [] | [] | 0 | [
"2jl1",
"2vrb",
"2vrc",
"2zcu",
"2zcv",
"3e48"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nitrosocosmicus oleophilus",
"Eukaryota",
"metagenomes"
] | [
12231,
1,
1786,
35
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | NmrA-type domain-containing oxidoreductase | NmrA-type domain-containing oxidoreductase | NmrA-type_oxidoreductase | 4 |
IPR052720 | 52,720 | Glycosyl Hydrolase Family 97 | Glycosyl_hydrolase_97 | Family | 9,497 | true | false | The glycosyl hydrolase 97 family encompasses enzymes with diverse substrate specificities, including alpha-galactosidases and glucan 1,4-alpha-glucosidases. Alpha-galactosidases in this family are capable of hydrolyzing alpha-1,6 disaccharides like melibiose and synthetic substrates such as p-nitrophenyl alpha-galactos... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35803"
] | [
"Glycosyl_hydrolase_97"
] | [
9497
] | 1 | [] | [] | [] | 0 | [
"2d73",
"2jka",
"2jke",
"2jkp",
"2zq0",
"3a24",
"3wfa",
"5e1q",
"5hq4",
"5hqa",
"5hqb",
"5hqc",
"5xfm",
"8wg0",
"8wg1",
"8wg2",
"9bs5"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Siphoviridae sp. ctYaH2",
"unclassified sequences"
] | [
9131,
70,
151,
1,
144
] | 5 | [] | [] | 0 | true | Family | Glycosyl Hydrolase Family 97 | Glycosyl Hydrolase Family 97 | Glycosyl_hydrolase_97 | 7 |
IPR052721 | 52,721 | Electron Transfer Amicyanin | ET_Amicyanin | Family | 5,649 | true | false | This family of proteins serves as electron transfer intermediates in bacterial respiratory chains. Members of this family accept electrons from methylamine dehydrogenase and subsequently transfer them to other electron carriers such as soluble cytochrome c or pseudoazurin. These proteins play a crucial role in the ener... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36507"
] | [
"ET_Amicyanin"
] | [
5649
] | 1 | [] | [] | [] | 0 | [
"1aac",
"1aaj",
"1aan",
"1bxa",
"1id2",
"1mda",
"1mg2",
"1mg3",
"1sf3",
"1sf5",
"1sfd",
"1sfh",
"1t5k",
"2gb2",
"2gba",
"2gc4",
"2gc7",
"2idq",
"2ids",
"2idt",
"2idu",
"2j55",
"2j56",
"2j57",
"2mta",
"2ov0",
"2qdv",
"2qdw",
"2rac",
"3c75",
"3ie9",
"3iea"... | 40 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1280,
4212,
37,
6,
114
] | 5 | [] | [] | 0 | true | Family | Electron Transfer Amicyanin | Electron Transfer Amicyanin | ET_Amicyanin | 4 |
IPR052722 | 52,722 | Cyclic-di-AMP phosphodiesterase PgpH | PgpH_phosphodiesterase | Family | 5,789 | true | false | The PgpH phosphodiesterase family is characterized by its enzymatic activity as a phosphodiesterase, primarily hydrolyzing cyclic di-3',5'-adenylate (c-di-AMP), a second messenger involved in various cellular processes such as growth, DNA repair, and cell wall homeostasis. Members of the PgpH family are considered to b... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36442"
] | [
"PgpH_phosphodiesterase"
] | [
5789
] | 1 | [] | [] | [] | 0 | [
"4s1b",
"4s1c"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5573,
4,
212
] | 3 | [] | [] | 0 | true | Family | Cyclic-di-AMP phosphodiesterase PgpH | Cyclic-di-AMP phosphodiesterase PgpH | PgpH_phosphodiesterase | 7 |
IPR052723 | 52,723 | Acyl-coenzyme A thioesterase PaaI | Acyl-CoA_thioesterase_PaaI | Family | 9,118 | true | false | This family of proteins includes thioesterases that exhibit a preference for hydroxylated phenylacetyl-CoA esters. Members are known to hydrolyze substrates such as 3,4-dihydroxyphenylacetyl-CoA, 3-hydroxyphenylacetyl-CoA, and 4-hydroxyphenylacetyl-CoA. They are characterized by their inability to act on 4-hydroxybenzo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42856"
] | [
"Acyl-CoA_thioesterase_PaaI"
] | [
9118
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.2.-",
"PWY-3602",
"PWY-5109",
"PWY-6322",
"PWY-6585",
"PWY-6917",
"PWY-6948",
"PWY-6995",
"PWY-6997",
"PWY-7007",
"PWY-7216",
"PWY-7292",
"PWY-7401",
"PWY-7402",
"PWY-7471",
"PWY-7690",
"PWY-7706",
"PWY-7733",
"PWY-7734",
"PWY-7738",
"PWY-7740",
"PWY-7741",
"PWY-7742... | [
"EC:3.1.2.-",
"METACYC:PWY-3602",
"METACYC:PWY-5109",
"METACYC:PWY-6322",
"METACYC:PWY-6585",
"METACYC:PWY-6917",
"METACYC:PWY-6948",
"METACYC:PWY-6995",
"METACYC:PWY-6997",
"METACYC:PWY-7007",
"METACYC:PWY-7216",
"METACYC:PWY-7292",
"METACYC:PWY-7401",
"METACYC:PWY-7402",
"METACYC:PWY-7... | 34 | [
"1ixl",
"1j1y",
"1psu",
"1wlu",
"1wlv",
"1wm6",
"1wn3",
"1zki",
"2dsl",
"2fs2"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
504,
8484,
16,
114
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Acyl-coenzyme A thioesterase PaaI | Acyl-coenzyme A thioesterase PaaI | Acyl-CoA_thioesterase_PaaI | 3 |
IPR052724 | 52,724 | Glycosyltransferase 117 domain-containing protein | GT117_domain-containing | Family | 5,790 | true | false | This family of proteins functions as O-mannosyl-transferases, enzymes that catalyze the transfer of mannosyl residues to the hydroxyl groups of serine or threonine residues within target proteins. They are known to specifically modify the IPT/TIG domain of certain proteins, such as MET and MST1R/RON. The mannosylation ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16214"
] | [
"GT117_domain-containing"
] | [
5790
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.4.1.109",
"PWY-7921",
"PWY-7922",
"PWY-7979"
] | [
"EC:2.4.1.109",
"METACYC:PWY-7921",
"METACYC:PWY-7922",
"METACYC:PWY-7979"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3982,
1641,
167
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
9,
5,
8
] | 4 | true | Family | Glycosyltransferase 117 domain-containing protein | Glycosyltransferase 117 domain-containing protein | GT117_domain-containing | 6 |
IPR052725 | 52,725 | Glutamine Synthetase Type-3 | GS_Type-3 | Family | 6,479 | true | false | This family of proteins includes enzymes that catalyze the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. These enzymes are not regulated by adenylation. Some members of this family may be inhibited by certain amino acids, such as L-histidine, L-arginine, and L-methionine-DL-sulphoximine, although ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42974"
] | [
"GS_Type-3"
] | [
6479
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.1.2",
"PWY-6963",
"PWY-6964",
"PWY-8291",
"PWY-8294"
] | [
"EC:6.3.1.2",
"METACYC:PWY-6963",
"METACYC:PWY-6964",
"METACYC:PWY-8291",
"METACYC:PWY-8294"
] | 5 | [
"3o6x",
"7u6o"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomassiliicoccales",
"metagenomes"
] | [
5650,
696,
3,
130
] | 4 | [] | [] | 0 | true | Family | Glutamine Synthetase Type-3 | Glutamine Synthetase Type-3 | GS_Type-3 | 5 |
IPR052726 | 52,726 | Bacteriophage Baseplate Hub | Phage_Baseplate_Hub | Family | 9,280 | true | false | This family of proteins is involved in the assembly and structural integrity of bacteriophage baseplates. The baseplate is a critical component of the phage that mediates host cell recognition and attachment, initiating the infection process. Members of this family are thought to function as hub proteins that may form ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35862"
] | [
"Phage_Baseplate_Hub"
] | [
9280
] | 1 | [] | [] | [] | 0 | [
"6u5b",
"6u5h",
"6u5k",
"9gtp"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
8984,
13,
270,
13
] | 4 | [] | [] | 0 | true | Family | Bacteriophage Baseplate Hub | Bacteriophage Baseplate Hub | Phage_Baseplate_Hub | 9 |
IPR052727 | 52,727 | Rab4/Rab5 effector domain-containing protein | Rab4/Rab5_effector | Family | 11,690 | true | false | This family of proteins includes effectors of Rab GTPases, specifically Rab4 and Rab5, involved in early endocytic membrane fusion and trafficking. Members of this family are essential for the fusion of endosomes and for the transport of recycling endosomes. They facilitate lysosomal trafficking of enzymes such as cath... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13510"
] | [
"Rab4/Rab5_effector"
] | [
11690
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-168138",
"R-HSA-983231",
"R-MMU-168138",
"R-MMU-983231",
"R-SCE-983231",
"R-SPO-983231"
] | [
"REACTOME:R-HSA-168138",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-168138",
"REACTOME:R-MMU-983231",
"REACTOME:R-SCE-983231",
"REACTOME:R-SPO-983231"
] | 6 | [
"1z0k"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11690
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
2,
1,
3,
3,
1,
3,
1,
1
] | 9 | true | Family | Rab4/Rab5 effector domain-containing protein | Rab4/Rab5 effector domain-containing protein | Rab4/Rab5_effector | 9 |
IPR052729 | 52,729 | Acyl/Acetyltransferase Enzymes | Acyl/Acetyltrans_Enzymes | Family | 7,778 | true | false | This family of proteins includes enzymes with acyltransferase and acetyltransferase activities. Members of this family are involved in the biosynthesis of various compounds, such as antibiotics, by catalyzing the transfer of acyl or acetyl groups from CoA-linked donors to acceptor molecules. Some proteins in this famil... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47237"
] | [
"Acyl/Acetyltrans_Enzymes"
] | [
7778
] | 1 | [] | [] | [] | 0 | [
"3ddd"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
110,
6486,
1150,
32
] | 4 | [
"Caenorhabditis elegans"
] | [
2
] | 1 | true | Family | Acyl/Acetyltransferase Enzymes | Acyl/Acetyltransferase Enzymes | Acyl/Acetyltrans_Enzymes | 4 |
IPR052731 | 52,731 | Bacillus subtilis Transition State Regulators | B_subtilis_Trans_State_Reg | Family | 7,412 | true | false | The Bacillus subtilis transition state regulator family includes proteins that play a critical role in the transition from vegetative growth to stationary phase and sporulation. Members of the family function as transcriptional regulators, acting as repressors or activators of genes involved in these developmental stag... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36432"
] | [
"B_subtilis_Trans_State_Reg"
] | [
7412
] | 1 | [] | [] | [] | 0 | [
"1yfb",
"1ysf",
"1z0r",
"2fy9",
"2k1n",
"2ro3",
"2ro4",
"2ro5",
"2w1t"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Phytophthora kernoviae 00238/432",
"unclassified sequences"
] | [
5,
7338,
17,
3,
49
] | 5 | [] | [] | 0 | true | Family | Bacillus subtilis Transition State Regulators | Bacillus subtilis Transition State Regulators | B_subtilis_Trans_State_Reg | 3 |
IPR052732 | 52,732 | Cell-binding uncharacterized protein | Cell-binding_unc_protein | Family | 7,579 | true | false | This family of proteins includes uncharacterized members that have been associated with cell-binding properties. Specifically, isolated peptides from one member have demonstrated the ability to interact with human monocytoblastic and epithelial cell lines. The exact biological functions and mechanisms of these proteins... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43883"
] | [
"Cell-binding_unc_protein"
] | [
7579
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
166,
6644,
625,
40,
104
] | 5 | [] | [] | 0 | true | Family | Cell-binding uncharacterized protein | Cell-binding uncharacterized protein | Cell-binding_unc_protein | 5 |
IPR052733 | 52,733 | Chloroplast-localized Quinone Oxidoreductase | Chloroplast_QOR | Family | 10,171 | true | false | This family of proteins includes NADPH-dependent quinone oxidoreductases that are involved in various redox reactions. Members of this family are capable of reducing quinones and other related compounds through single-electron transfers. These enzymes play roles in processes such as haustorium initiation in parasitic p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44013"
] | [
"Chloroplast_QOR"
] | [
10171
] | 1 | [] | [] | [] | 0 | [
"3tqh",
"5a3j",
"5a3v",
"5a4d"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
35,
6259,
3764,
113
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
25,
22
] | 3 | true | Family | Chloroplast-localized Quinone Oxidoreductase | Chloroplast-localized Quinone Oxidoreductase | Chloroplast_QOR | 5 |
IPR052734 | 52,734 | Nodulation factor acetyltransferase | Nod_factor_acetyltransferase | Family | 7,748 | true | false | This family of proteins is thought to function as acetyltransferases, with a specific role in modifying the fucose component of nodulation factors. These modifications are important in the nodulation process, which is a key aspect of the symbiotic relationship between certain plants and nitrogen-fixing bacteria. The pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37312"
] | [
"Nod_factor_acetyltransferase"
] | [
7748
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
38,
7620,
62,
28
] | 4 | [] | [] | 0 | true | Family | Nodulation factor acetyltransferase | Nodulation factor acetyltransferase | Nod_factor_acetyltransferase | 6 |
IPR052735 | 52,735 | Bacterial NAD biosynthesis/regulator protein | NAD_biosynth-regulator | Family | 7,028 | true | false | This family of proteins includes enzymes with multiple activities involved in NAD biosynthesis and regulation. They possess nicotinamide mononucleotide (NMN) adenylyltransferase activity, catalyzing the formation of NAD(+) from nicotinamide ribonucleotide and ATP. Additionally, they exhibit ribosylnicotinamide (RN) kin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37512"
] | [
"NAD_biosynth-regulator"
] | [
7028
] | 1 | [
"EC",
"EC"
] | [
"2.7.1.22",
"2.7.7.1"
] | [
"EC:2.7.1.22",
"EC:2.7.7.1"
] | 2 | [
"1lw7",
"6gye",
"6gyf",
"6gzo",
"8x7f"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanimicrococcus",
"Viruses",
"metagenomes"
] | [
6754,
34,
2,
182,
56
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterial NAD biosynthesis/regulator protein | Bacterial NAD biosynthesis/regulator protein | NAD_biosynth-regulator | 7 |
IPR052736 | 52,736 | Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3 | Stf3_sulfotransferase | Family | 5,640 | true | false | The Stf3 family is involved in the biosynthesis of sulfomenaquinone (SMK), a compound that plays a role in the regulation of virulence in mycobacteria. Members of the Stf3 family are enzymes that catalyze the sulfonation of omega-hydroxy-beta-dihydromenaquinone-9 using 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36451"
] | [
"Stf3_sulfotransferase"
] | [
5640
] | 1 | [
"EC",
"METACYC"
] | [
"2.8.2.40",
"PWY-7781"
] | [
"EC:2.8.2.40",
"METACYC:PWY-7781"
] | 2 | [
"2z6v",
"2zq5"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9,
4911,
596,
124
] | 4 | [] | [] | 0 | true | Family | Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3 | Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3 | Stf3_sulfotransferase | 2 |
IPR052737 | 52,737 | Omega-amidase YafV | Omega-amidase_YafV | Family | 6,143 | true | false | The Omega-amidase YafV family consists of enzymes that play a role in amino acid metabolism and possibly in metabolite repair. Members of this family are characterized by their ability to hydrolyze alpha-ketoglutaramate (a-KGM) to alpha-ketoglutarate (alpha-KG) and ammonia. The enzymes exhibit varying specific activiti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47799"
] | [
"Omega-amidase_YafV"
] | [
6143
] | 1 | [
"EC",
"METACYC"
] | [
"3.5.1.3",
"PWY-4002"
] | [
"EC:3.5.1.3",
"METACYC:PWY-4002"
] | 2 | [
"2e11"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7,
5963,
65,
108
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Omega-amidase YafV | Omega-amidase YafV | Omega-amidase_YafV | 4 |
IPR052738 | 52,738 | ABC transporter tungstate-binding | ABC-Tungstate_binding | Family | 4,605 | true | false | This family of proteins is involved in the transport of anions, particularly tungstate, across cellular membranes. They are components of ABC transporter complexes, which are known for their role in high-affinity uptake systems. Members of this family exhibit specificity for tungstate and are essential for its uptake, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37945"
] | [
"ABC-Tungstate_binding"
] | [
4605
] | 1 | [] | [] | [] | 0 | [
"3cvg",
"3kn3",
"3lr1",
"3muq",
"5my5"
] | 5 | [] | [] | [] | [] | 0 | [] | [
"IPR053775"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
477,
3273,
733,
122
] | 4 | [] | [] | 0 | true | Family | ABC transporter tungstate-binding | ABC transporter tungstate-binding | ABC-Tungstate_binding | 1 |
IPR052739 | 52,739 | Fatty-acid amide hydrolase 2 | FAAH2 | Family | 7,207 | true | false | This family of proteins is involved in the metabolic regulation of endogenous fatty acid amides. Members of this family function as enzymes that catalyze the hydrolysis of fatty amides, including sleep-inducing and signaling lipids such as oleamide and anandamide, into their respective fatty acids. This hydrolytic acti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43372"
] | [
"FAAH2"
] | [
7207
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.5.1.99",
"R-DRE-2142753",
"R-HSA-2142753"
] | [
"EC:3.5.1.99",
"REACTOME:R-DRE-2142753",
"REACTOME:R-HSA-2142753"
] | 3 | [
"5h6s",
"5h6t",
"8es6",
"8s7z",
"8wdw",
"8xtb",
"8xtc",
"9fvf",
"9fw1",
"9fz1",
"9fzw",
"9giz",
"9je9"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8,
2987,
4082,
130
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens"
] | [
1,
4,
9,
2
] | 4 | true | Family | Fatty-acid amide hydrolase 2 | Fatty-acid amide hydrolase 2 | FAAH2 | 7 |
IPR052741 | 52,741 | Mitochondrial Hydroxyacyl-thioester Dehydratase | Mitochondrial_HTD2 | Family | 6,351 | true | false | The HTD2 family comprises mitochondrial enzymes involved in fatty acid biosynthesis and the glyoxylate assimilation cycle. Members of the HTD2 family, such as Hydroxyacyl-thioester dehydratase type 2, play a crucial role in respiratory growth and maintaining normal mitochondrial morphology by catalyzing the dehydration... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28152"
] | [
"Mitochondrial_HTD2"
] | [
6351
] | 1 | [] | [] | [] | 0 | [
"8huc",
"8khg"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3928,
2386,
37
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Family | Mitochondrial Hydroxyacyl-thioester Dehydratase | Mitochondrial Hydroxyacyl-thioester Dehydratase | Mitochondrial_HTD2 | 4 |
IPR052742 | 52,742 | Mitochondrial N-acetyltransferase | Mito_N-acetyltransferase | Family | 6,410 | true | false | This family of proteins includes N-acetyltransferases involved in the cellular response to oxidative stress. Members of this family are known to acetylate intermediates in proline metabolism, specifically the (S)-1-pyrroline-5-carboxylate (P5C) or its tautomer glutamate-5-semialdehyde (GSA), which are implicated in arg... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43138"
] | [
"Mito_N-acetyltransferase"
] | [
6410
] | 1 | [] | [] | [] | 0 | [
"3w6s",
"3w6x",
"3w91",
"4h89",
"4lua"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"metagenomes"
] | [
4197,
2179,
13,
21
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Mitochondrial N-acetyltransferase | Mitochondrial N-acetyltransferase | Mito_N-acetyltransferase | 6 |
IPR052743 | 52,743 | Fungal Glutaminase GtaA | Glutaminase_GtaA | Family | 6,899 | true | false | This family of proteins includes enzymes that catalyze the hydrolysis of glutamine to glutamic acid, a reaction that is central to nitrogen metabolism. Members of this family are capable of processing both L-glutamine and D-glutamine. The enzymatic activity of these proteins is crucial for the production of glutamic ac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31987"
] | [
"Glutaminase_GtaA"
] | [
6899
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
1586,
5293,
2,
18
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
4,
1
] | 2 | true | Family | Fungal Glutaminase GtaA | Fungal Glutaminase GtaA | Glutaminase_GtaA | 6 |
IPR052744 | 52,744 | Glycerol-3-phosphate O-acyltransferase | GPAT/DAPAT | Family | 4,971 | true | false | This family of proteins includes enzymes with acyltransferase activity, specifically functioning as glycerol-3-phosphate O-acyltransferases. They catalyze the initial step in the biosynthesis of glycerophospholipids and triacylglycerols, transferring a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31605"
] | [
"GPAT/DAPAT"
] | [
4971
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"ecological metagenomes"
] | [
987,
3942,
10,
32
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | Glycerol-3-phosphate O-acyltransferase | Glycerol-3-phosphate O-acyltransferase | GPAT/DAPAT | 6 |
IPR052745 | 52,745 | Glycerol 3-phosphate Oxidase/Oxidoreductase | G3P_Oxidase/Oxidoreductase | Family | 4,156 | true | false | This family of proteins includes enzymes that are involved in the metabolism of glycerol. They catalyze the oxidation of glycerol 3-phosphate (G3P) to dihydroxyacetone phosphate (DHAP), a key step in glycerol utilization and energy production. Some members of this family are also capable of oxidizing glyceraldehyde 3-p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42720"
] | [
"G3P_Oxidase/Oxidoreductase"
] | [
4156
] | 1 | [] | [] | [] | 0 | [
"4x9m",
"4x9n"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
120,
3613,
277,
146
] | 4 | [] | [] | 0 | true | Family | Glycerol 3-phosphate Oxidase/Oxidoreductase | Glycerol 3-phosphate Oxidase/Oxidoreductase | G3P_Oxidase/Oxidoreductase | 5 |
IPR052746 | 52,746 | MlaB ABC Transporter Complex Protein | MlaB_ABC_Transporter | Family | 5,170 | true | false | This family of proteins is involved in an ABC transporter complex known as MlaFEDB, which plays a crucial role in maintaining lipid asymmetry in the outer membrane of certain bacteria. These proteins are responsible for the retrograde trafficking of phospholipids from the outer membrane back to the inner membrane, a pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35849"
] | [
"MlaB_ABC_Transporter"
] | [
5170
] | 1 | [] | [] | [] | 0 | [
"6xbd",
"6xgy",
"6xgz",
"6zy2",
"6zy3",
"6zy4",
"6zy9",
"7cge",
"7cgn",
"7ch0",
"7ch6",
"7ch7"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5113,
3,
54
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | MlaB ABC Transporter Complex Protein | MlaB ABC Transporter Complex Protein | MlaB_ABC_Transporter | 4 |
IPR052747 | 52,747 | Type II TA system RelE toxin | TA_system_RelE_toxin | Family | 3,222 | true | false | This family of proteins includes toxic components of type II toxin-antitoxin (TA) systems. They exhibit ribonuclease activity and are involved in the regulation of cellular processes through their interaction with cognate antitoxins. These proteins are typically encoded by operons that also encode their respective anti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38813"
] | [
"TA_system_RelE_toxin"
] | [
3222
] | 1 | [] | [] | [] | 0 | [
"1wmi",
"3bpq"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Ecdysozoa",
"unclassified sequences"
] | [
367,
2750,
28,
4,
73
] | 5 | [] | [] | 0 | true | Family | Type II TA system RelE toxin | Type II TA system RelE toxin | TA_system_RelE_toxin | 6 |
IPR052748 | 52,748 | Integrated Stress Response Activator | ISR_Activator | Family | 5,222 | true | false | This family of proteins acts as activators of the integrated stress response (ISR), particularly in response to iron deficiency and mitochondrial stress. Members of this family detect impaired protein import into mitochondria, leading to their localization at the mitochondrial surface. There, they bind to and activate ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45011"
] | [
"ISR_Activator"
] | [
5222
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9840373",
"R-MMU-9840373",
"R-RNO-9840373"
] | [
"REACTOME:R-HSA-9840373",
"REACTOME:R-MMU-9840373",
"REACTOME:R-RNO-9840373"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megavirus baoshan",
"Methanomethylophilus alvi",
"unclassified sequences"
] | [
2227,
2908,
1,
4,
82
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
5,
4
] | 4 | true | Family | Integrated Stress Response Activator | Integrated Stress Response Activator | ISR_Activator | 2 |
IPR052750 | 52,750 | Glycosyl Hydrolase 18 Chitinase | GH18_Chitinase | Family | 5,579 | true | false | This family of proteins includes enzymes with chitinase activity, which are involved in the degradation of chitin. Chitin is a major component of fungal cell walls and the exoskeletons of arthropods and other animals. Members of this family play a role in various biological processes, including the breakdown of chitin ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42976"
] | [
"GH18_Chitinase"
] | [
5579
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.2.1.14",
"PWY-6855",
"PWY-6902",
"PWY-7822"
] | [
"EC:3.2.1.14",
"METACYC:PWY-6855",
"METACYC:PWY-6902",
"METACYC:PWY-7822"
] | 4 | [
"2dsk",
"3a4w",
"3a4x",
"3afb",
"9buf"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megaviricetes",
"Methanobacteriota",
"metagenomes"
] | [
5257,
196,
14,
76,
36
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Glycosyl Hydrolase 18 Chitinase | Glycosyl Hydrolase 18 Chitinase | GH18_Chitinase | 9 |
IPR052751 | 52,751 | Plant MAP kinase kinase kinase | Plant_MAPKKK | Family | 8,984 | true | false | This family of proteins includes mitogen-activated protein kinase kinase kinases (MAPKKKs) that are integral components of the abscisic acid (ABA) signaling pathway, particularly in response to abiotic stresses. They are involved in the activation of downstream MAP kinases, such as MPK1, MPK2, MPK6, MPK7, and MPK14, th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48011"
] | [
"Plant_MAPKKK"
] | [
8984
] | 1 | [
"EC"
] | [
"2.7.11.25"
] | [
"EC:2.7.11.25"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Ictalurid herpesvirus 1 (strain Auburn)",
"Thermoprotei",
"metagenomes"
] | [
241,
8733,
1,
3,
6
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
125,
36,
28
] | 3 | true | Family | Plant MAP kinase kinase kinase | Plant MAP kinase kinase kinase | Plant_MAPKKK | 7 |
IPR052752 | 52,752 | NACHT and WD repeat domain-containing protein | NACHT-WD_repeat | Family | 6,344 | true | false | This family of proteins includes members that contain NACHT and WD repeat domains. The NACHT domain is typically involved in nucleotide binding and signal transduction, often playing a role in the regulation of inflammatory and immune responses. The WD repeat domain is known for mediating protein-protein interactions, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19871"
] | [
"NACHT-WD_repeat"
] | [
6344
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina",
"ecological metagenomes"
] | [
180,
6156,
3,
5
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
10,
8,
2,
4,
4
] | 6 | true | Family | NACHT and WD repeat domain-containing protein | NACHT and WD repeat domain-containing protein | NACHT-WD_repeat | 3 |
IPR052753 | 52,753 | Rubrerythrin-2/Nigerythrin | Rbr2/Nigerythrin | Family | 2,336 | true | true | This protein family is involved in peroxidase activity, specifically utilizing NADH as an electron donor to reduce hydrogen peroxide (H2O2). Members of the family, such as Nigerythrin and Rubrerythrin-2, function in oxidative stress response by catalysing the conversion of H2O2 into water, thereby protecting the cell f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33746"
] | [
"NADH_Peroxidase_Act"
] | [
2336
] | 1 | [] | [] | [] | 0 | [
"1j30",
"1nnq",
"1yux",
"1yuz",
"1yv1",
"2hr5",
"3mps",
"3pwf",
"3pza",
"3qhb",
"3qhc",
"3qvd",
"3sid",
"4di0",
"7o89",
"7o8a",
"7o8d",
"7o90",
"7o91",
"7o93",
"7o99",
"7o9c",
"7o9d",
"7o9e",
"7ppt",
"7ppu",
"7ppv",
"8fuh",
"8fvv",
"8fxd",
"9onm",
"9onn"... | 36 | [
"PUB00038641",
"PUB00154865"
] | [
"15895271",
"21872605"
] | [
"High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins.",
"Symerythrin structures at atomic resolution and the origins of rubrerythrins and the ferritin-like superf... | [
2005,
2011
] | 2 | [] | [
"IPR054800"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
338,
1841,
26,
124,
7
] | 5 | [] | [] | 0 | true | Family | Rubrerythrin-2/Nigerythrin | Rubrerythrin-2/Nigerythrin | Rbr2/Nigerythrin | 3 |
IPR052754 | 52,754 | NTPase KAP P-loop domain-containing protein | NTPase_KAP_P-loop | Family | 4,282 | true | false | This family of proteins includes members that are involved in nucleotide triphosphate (NTP) hydrolysis, which is a common molecular function that provides energy for various cellular processes. Additionally, some members of this family are associated with bacterial immunity, specifically the inhibition of bacteriophage... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22674"
] | [
"NTPase_KAP_P-loop"
] | [
4282
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
77,
3068,
1092,
3,
42
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
3,
3
] | 5 | true | Family | NTPase KAP P-loop domain-containing protein | NTPase KAP P-loop domain-containing protein | NTPase_KAP_P-loop | 2 |
IPR052755 | 52,755 | Lysozyme Inhibitor LprI | Lysozyme_Inhibitor_LprI | Family | 4,237 | true | false | This family of proteins is characterized by a strong affinity for lysozyme, which they bind and inhibit. This interaction is thought to be a defensive mechanism, allowing bacteria to evade the antimicrobial effects of lysozyme, an enzyme commonly found in host cells. The proteins are implicated in enhancing bacterial s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37549"
] | [
"Lysozyme_Inhibitor_LprI"
] | [
4237
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Rhynchophorus ferrugineus",
"metagenomes"
] | [
4187,
43,
1,
6
] | 4 | [] | [] | 0 | true | Family | Lysozyme Inhibitor LprI | Lysozyme Inhibitor LprI | Lysozyme_Inhibitor_LprI | 4 |
IPR052756 | 52,756 | Terminal-alkyne amino-acid exporter | Alkyne_AA_exporter | Family | 3,960 | true | false | This family of proteins includes transporters that are part of the EamA transporter family. Members of this family are likely to be involved in the export of specific amino acids that have terminal alkyne groups, which may have antibiotic properties. These amino acids include L-propargylglycine and L-beta-ethynylserine... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12715"
] | [
"Alkyne_AA_exporter"
] | [
3960
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rhynchospora breviuscula",
"unclassified sequences"
] | [
11,
3895,
1,
53
] | 4 | [] | [] | 0 | true | Family | Terminal-alkyne amino-acid exporter | Terminal-alkyne amino-acid exporter | Alkyne_AA_exporter | 4 |
IPR052757 | 52,757 | Bacterial ribosomal protein S1 | Ribosomal_protein_S1 | Family | 1,392 | true | false | This family of proteins is involved in the initial stages of protein synthesis by binding to messenger RNA (mRNA) and playing a role in the assembly of the small ribosomal subunit. These proteins are essential for the translation process, ensuring the proper alignment of mRNA and ribosomes for efficient decoding of gen... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47559"
] | [
"Ribosomal_protein_S1"
] | [
1392
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
569,
815,
8
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
4,
8
] | 3 | true | Family | Bacterial ribosomal protein S1 | Bacterial ribosomal protein S1 | Ribosomal_protein_S1 | 9 |
IPR052758 | 52,758 | Steroid receptor co-chaperone | SRC_co-chaperone | Family | 2,475 | true | false | This family of proteins functions as co-chaperones that regulate the activity of the molecular chaperones HSP70 and HSP90. They are involved in the folding process of steroid receptors, including glucocorticoid and progesterone receptors. These proteins are suggested to have a role in recycling chaperone substrates bac... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44200"
] | [
"SRC_co-chaperone"
] | [
2475
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Tupanvirus"
] | [
91,
2382,
2
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
5,
1,
2
] | 4 | true | Family | Steroid receptor co-chaperone | Steroid receptor co-chaperone | SRC_co-chaperone | 9 |
IPR052759 | 52,759 | Extracellular Metalloprotease M4 | Metalloprotease_M4 | Family | 4,420 | true | false | This family of proteins includes extracellular metalloproteases that are characterized by their ability to interact with and degrade peptide substrates. Members of this family are involved in various biological processes, including the modulation of antibacterial peptide activity. One known function is the inhibition o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43579"
] | [
"Metalloprotease_M4"
] | [
4420
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.24.-",
"PWY-8119"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119"
] | 2 | [
"2vqx"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
15,
3826,
565,
14
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Extracellular Metalloprotease M4 | Extracellular Metalloprotease M4 | Metalloprotease_M4 | 4 |
IPR052760 | 52,760 | Mitochondrial malonyltransferase | Mitochondrial_malonyltrans | Family | 3,561 | true | false | This family of proteins catalyzes the transfer of malonyl groups from malonyl-CoA to the phosphopantetheine arm of acyl carrier proteins within mitochondria, indicating a role in mitochondrial fatty acid biosynthesis. Members of this family share a common function in the elongation step of fatty acid synthesis, which i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47170"
] | [
"Mitochondrial_malonyltrans"
] | [
3561
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.1.39",
"PWY-4381",
"PWY-6799",
"PWY-8012",
"PWY-8047",
"PWY-8049",
"PWY-8438",
"R-DME-77289",
"R-HSA-77289",
"R-MMU-77289"
] | [
"EC:2.3.1.39",
"METACYC:PWY-4381",
"METACYC:PWY-6799",
"METACYC:PWY-8012",
"METACYC:PWY-8047",
"METACYC:PWY-8049",
"METACYC:PWY-8438",
"REACTOME:R-DME-77289",
"REACTOME:R-HSA-77289",
"REACTOME:R-MMU-77289"
] | 10 | [
"2c2n",
"8csp",
"8csq",
"8csr",
"8css"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
445,
3087,
29
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
1,
2,
4,
3,
2,
7
] | 9 | true | Family | Mitochondrial malonyltransferase | Mitochondrial malonyltransferase | Mitochondrial_malonyltrans | 3 |
IPR052761 | 52,761 | Fungal Detoxification and Toxin Biosynthesis TFs | Fungal_Detox/Toxin_TFs | Family | 5,311 | true | false | The protein family includes transcription factors involved in the regulation of gene clusters responsible for the detoxification and degradation of specific compounds, as well as the biosynthesis of fungal toxins. One member regulates the Fusarium detoxification of benzoxazolinone cluster, contributing to the tolerance... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47425"
] | [
"Fungal_Detox/Toxin_TFs"
] | [
5311
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5311
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Fungal Detoxification and Toxin Biosynthesis TFs | Fungal Detoxification and Toxin Biosynthesis TFs | Fungal_Detox/Toxin_TFs | 8 |
IPR052762 | 52,762 | Plant cell wall deacetylase/carbohydrate esterase | PCW_deacetylase/CE | Family | 3,966 | true | false | This family of proteins is involved in the degradation of plant cell wall polysaccharides. Members exhibit esterase activity, catalyzing the deacetylation of acetylated plant polysaccharides such as birchwood xylan and glucomannan. Some family members also display endoglucanase activity against substrates like carboxym... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37834"
] | [
"PCW_deacetylase/CE"
] | [
3966
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"3.1.1.-",
"3.1.1.72",
"PWY-1921",
"PWY-5835",
"PWY-6190",
"PWY-6308",
"PWY-6322",
"PWY-6339",
"PWY-6415",
"PWY-6558",
"PWY-6848",
"PWY-7002",
"PWY-7352",
"PWY-7367",
"PWY-7521",
"PWY-7599",
"PWY-7660",
"PWY-7712",
"PWY-7713",
"PWY-7730",
"PWY-7769",
"PWY-7982",
"PWY-8058... | [
"EC:3.1.1.-",
"EC:3.1.1.72",
"METACYC:PWY-1921",
"METACYC:PWY-5835",
"METACYC:PWY-6190",
"METACYC:PWY-6308",
"METACYC:PWY-6322",
"METACYC:PWY-6339",
"METACYC:PWY-6415",
"METACYC:PWY-6558",
"METACYC:PWY-6848",
"METACYC:PWY-7002",
"METACYC:PWY-7352",
"METACYC:PWY-7367",
"METACYC:PWY-7521",... | 29 | [
"2w9x",
"2waa",
"2wab",
"2wao",
"3u37",
"4dev",
"4xvh"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Skunavirus",
"metagenomes"
] | [
2581,
1354,
20,
11
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Plant cell wall deacetylase/carbohydrate esterase | Plant cell wall deacetylase/carbohydrate esterase | PCW_deacetylase/CE | 5 |
IPR052763 | 52,763 | DnaJ Homolog Subfamily C Member 4 | DnaJ_C4 | Family | 3,609 | true | false | The DnaJ homolog subfamily C member 4 family is implicated in cellular processes that may be crucial during spermatogenesis and/or within the male genital tract. Members of this family are likely to assist in the folding of nascent polypeptide chains and the refolding of denatured proteins, acting as molecular chaperon... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44825"
] | [
"DnaJ_C4"
] | [
3609
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
73,
1073,
2436,
3,
24
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
5,
6,
4,
8
] | 6 | true | Family | DnaJ Homolog Subfamily C Member 4 | DnaJ Homolog Subfamily C Member 4 | DnaJ_C4 | 8 |
IPR052764 | 52,764 | Glycosyl Hydrolase 20 Enzymes | GH20_Enzymes | Family | 4,125 | true | false | This family of proteins is involved in the hydrolysis of glycosidic bonds, specifically those in mucopolysaccharides and oligosaccharides. Members of this family exhibit enzymatic activity that cleaves specific linkages in substrates such as mucin, a component of the human intestinal tract, and human milk oligosacchari... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43678"
] | [
"GH20_Enzymes"
] | [
4125
] | 1 | [] | [] | [] | 0 | [
"1yht",
"2yl5",
"2yl6",
"2yl8",
"2yl9",
"2yla",
"2yll",
"3rpm",
"4az5",
"4az6",
"4az7",
"4azb",
"4azc",
"4azg",
"4azh",
"4azi",
"4h04",
"4jaw",
"5bxp",
"5bxr",
"5bxs",
"5bxt",
"6jqf",
"7ezt",
"7pul",
"8hvb",
"8hvc",
"8hvd",
"8qak",
"8qb6",
"8qce",
"9fyn"... | 34 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3037,
1080,
8
] | 3 | [] | [] | 0 | true | Family | Glycosyl Hydrolase 20 Enzymes | Glycosyl Hydrolase 20 Enzymes | GH20_Enzymes | 7 |
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