interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR052765 | 52,765 | Phosphoglycerate Mutase-Related | PGM-Related | Family | 4,734 | true | false | This family of proteins includes enzymes that are related to the phosphoglycerate mutase (PGM) family, which are traditionally known to be involved in glycolysis and gluconeogenesis by catalyzing the interconversion of 3-phosphoglycerate and 2-phosphoglycerate. Members of this family may not all exhibit PGM enzymatic a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46192"
] | [
"PGM-Related"
] | [
4734
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Acinetobacter phage vB_AbaM_ME3",
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
1,
1391,
3340,
2
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
10,
1,
10,
1,
18
] | 5 | true | Family | Phosphoglycerate Mutase-Related | Phosphoglycerate Mutase-Related | PGM-Related | 3 |
IPR052766 | 52,766 | Secondary metabolite-associated S41A peptidase | S41A_metabolite_peptidase | Family | 4,902 | true | false | This family of proteins includes serine peptidases belonging to the S41A subfamily. They play a crucial role in the biosynthesis of various secondary metabolites, such as hexapeptide mycotoxins and antimitotic tetrapeptides. These enzymes are involved in the proteolytic processing of precursor peptides, which is a key ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37049"
] | [
"S41A_metabolite_peptidase"
] | [
4902
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudoalteromonas luteoviolacea",
"Sclerotinia sclerotiorum mitovirus 9-U"
] | [
4897,
4,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Secondary metabolite-associated S41A peptidase | Secondary metabolite-associated S41A peptidase | S41A_metabolite_peptidase | 1 |
IPR052767 | 52,767 | Bacterial community development regulator | Bact_com_dev_regulator | Family | 4,056 | true | false | This family of proteins includes members that are implicated in bacterial community development and regulatory processes. Some proteins in this family are thought to interact with other proteins to modulate community dynamics, possibly by influencing cellular differentiation or communication. Specifically, certain memb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38448"
] | [
"Bact_com_dev_regulator"
] | [
4056
] | 1 | [] | [] | [] | 0 | [
"2pih",
"6prh",
"6prk"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"Phytophthora cactorum",
"bioreactor metagenome"
] | [
4033,
19,
1,
3
] | 4 | [] | [] | 0 | true | Family | Bacterial community development regulator | Bacterial community development regulator | Bact_com_dev_regulator | 2 |
IPR052768 | 52,768 | RNA-binding protein 25 | RBM25 | Family | 4,702 | false | false | This family of proteins is involved in the regulation of alternative pre-mRNA splicing and plays a role in apoptotic cell death. Members of this family includes RNA-binding protein 25 (RBM25) from human and its orthologue from S.pombe U1 snRNP-associated protein usp107. RBM25 modulates the expression of the apoptotic f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR18806"
] | [
""
] | [
4702
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-72163",
"R-MMU-72163"
] | [
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163"
] | 2 | [
"3v53"
] | 1 | [
"PUB00083044",
"PUB00083045",
"PUB00083052"
] | [
"18663000",
"21859973",
"17264129"
] | [
"Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.",
"Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.",
"Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals three essential organism-specific proteins."
] | [
2008,
2011,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4702
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
3,
11,
5,
7,
1,
11,
1
] | 8 | true | Family | RNA-binding protein 25 | RNA-binding protein 25 | RBM25 | 2 |
IPR052769 | 52,769 | Tetratricopeptide repeat domain-containing protein | TPR_domain_protein | Family | 4,799 | true | false | This family of proteins contains tetratricopeptide repeat (TPR) motifs, which are known to mediate protein-protein interactions. These interactions are crucial for the assembly of multiprotein complexes. The TPR motif consists of 34 amino acids and forms a helix-turn-helix structure. Proteins in this family are involve... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46014"
] | [
"TPR_domain_protein"
] | [
4799
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)"
] | [
23,
4775,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
3,
1,
8,
3,
1,
4,
4,
6
] | 10 | true | Family | Tetratricopeptide repeat domain-containing protein | Tetratricopeptide repeat domain-containing protein | TPR_domain_protein | 9 |
IPR052770 | 52,770 | Cobalt transport CbiQ | Cobalt_transport_CbiQ | Family | 3,506 | true | false | This family of proteins is involved in the transport of metal ions across cellular membranes, specifically cobalt. Members of this family are components of the energy-coupling factor (ECF) transporter complex, which plays a crucial role in the uptake of cobalt ions. The complex has been shown to facilitate cobalt impor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43723"
] | [
"Cobalt_transport_CbiQ"
] | [
3506
] | 1 | [] | [] | [] | 0 | [
"5x3x",
"5x41"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
259,
3231,
16
] | 3 | [] | [] | 0 | true | Family | Cobalt transport CbiQ | Cobalt transport CbiQ | Cobalt_transport_CbiQ | 5 |
IPR052771 | 52,771 | Neurotrophin-activated signaling adaptor | Neurotrophin_sig_adaptor | Family | 4,490 | true | false | This family of proteins is involved in signal transduction pathways related to neuronal development, regeneration, and synaptic signaling. Members of this family promote sustained MAP-kinase signaling through a Rap1-dependent mechanism, which is activated by neurotrophins. They serve as docking sites for complexes like... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24116"
] | [
"Neurotrophin_sig_adaptor"
] | [
4490
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-170984",
"R-DRE-9696270",
"R-DRE-9696273",
"R-HSA-170984",
"R-HSA-9696270",
"R-HSA-9696273",
"R-RNO-170984",
"R-RNO-9696270",
"R-RNO-9696273"
] | [
"REACTOME:R-DRE-170984",
"REACTOME:R-DRE-9696270",
"REACTOME:R-DRE-9696273",
"REACTOME:R-HSA-170984",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-RNO-170984",
"REACTOME:R-RNO-9696270",
"REACTOME:R-RNO-9696273"
] | 9 | [
"9jxq"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
25,
4462,
3
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
19,
18,
24,
16,
17
] | 6 | true | Family | Neurotrophin-activated signaling adaptor | Neurotrophin-activated signaling adaptor | Neurotrophin_sig_adaptor | 7 |
IPR052772 | 52,772 | Endonuclease/Polynucleotide Kinase Domain-Containing Protein | Endo/PolyKinase_Domain-Protein | Family | 3,946 | true | false | This family of proteins includes enzymes with endonuclease activity that are involved in mRNA surveillance and DNA repair or recombination processes. Members of this family are capable of recognizing and binding specific polyubiquitinated proteins, which facilitates their recruitment to sites of action such as stalled ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46535"
] | [
"Endo/PolyKinase_Domain-Protein"
] | [
3946
] | 1 | [] | [] | [] | 0 | [
"2d9i",
"2vkc",
"3fau"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Eukaryota",
"Vibrio",
"uncultured organism MedDCM-OCT-S09-C568"
] | [
4,
3933,
8,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
3,
2,
5,
4,
1,
5,
1,
1
] | 9 | true | Family | Endonuclease/Polynucleotide Kinase Domain-Containing Protein | Endonuclease/Polynucleotide Kinase Domain-Containing Protein | Endo/PolyKinase_Domain-Protein | 9 |
IPR052773 | 52,773 | Anaerobic Bacterial Peroxidase-Related | Anaerobic_Peroxidase-Rel | Family | 2,220 | true | false | This family of proteins includes enzymes that play a crucial role in the oxidative stress defense system of certain obligate anaerobic bacteria. Members of this family function as terminal components of an NADH peroxidase system, utilizing NADH:rubredoxin oxidoreductase and rubredoxin as electron transport intermediari... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43339"
] | [
"Anaerobic_Peroxidase-Rel"
] | [
2220
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"metagenomes"
] | [
2042,
126,
52
] | 3 | [] | [] | 0 | true | Family | Anaerobic Bacterial Peroxidase-Related | Anaerobic Bacterial Peroxidase-Related | Anaerobic_Peroxidase-Rel | 7 |
IPR052774 | 52,774 | C. elegans Developmental and Neuronal Protein | Celegans_DevNeuronal_Protein | Family | 4,866 | true | false | This family of proteins is involved in various developmental and morphogenetic processes in Caenorhabditis elegans. Members of this family play crucial roles in epithelial tube development, including the morphogenesis and function of unicellular tubes within the excretory system such as the canal cell, duct cell, and p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47327"
] | [
"Celegans_DevNeuronal_Protein"
] | [
4866
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
4863,
3
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
18,
22
] | 2 | true | Family | C. elegans Developmental and Neuronal Protein | C. elegans Developmental and Neuronal Protein | Celegans_DevNeuronal_Protein | 4 |
IPR052775 | 52,775 | Inosine-uridine nucleoside hydrolase | IUN_hydrolase | Family | 4,043 | true | false | This family of proteins is involved in the hydrolysis of the N-glycosidic bond of purine and pyrimidine nucleosides, resulting in the separation of ribose and the base. The enzymatic activity varies with different substrates, showing a preference for adenosine, followed by guanosine, inosine, xanthosine, cytidine, and ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46190"
] | [
"IUN_hydrolase"
] | [
4043
] | 1 | [] | [] | [] | 0 | [
"3fz0",
"3t8i",
"5mj7",
"8db6",
"8db7",
"8db8",
"8db9"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
155,
1135,
2730,
23
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster"
] | [
2,
6,
4
] | 3 | true | Family | Inosine-uridine nucleoside hydrolase | Inosine-uridine nucleoside hydrolase | IUN_hydrolase | 8 |
IPR052776 | 52,776 | Chloroplast-associated Reproductive Support & Metal Ion Transport | Chloro_ReproSupport/MetalTrans | Family | 2,392 | true | false | This family of proteins includes essential components involved in plant reproductive processes, specifically female gametogenesis and embryogenesis. Members of this family are believed to play a crucial role in ensuring an adequate energy supply within chloroplasts during these critical stages of plant development. Add... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33876"
] | [
"Chloro_ReproSupport/MetalTrans"
] | [
2392
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
58,
889,
1404,
41
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
6,
5
] | 3 | true | Family | Chloroplast-associated Reproductive Support & Metal Ion Transport | Chloroplast-associated Reproductive Support & Metal Ion Transport | Chloro_ReproSupport/MetalTrans | 4 |
IPR052777 | 52,777 | Acetyltransferase Enzymes | Acetyltransferase_Enz | Family | 2,851 | true | false | This family of proteins includes enzymes that catalyze the transfer of acetyl groups from acetyl coenzyme A to various acceptor substrates, resulting in the release of CoA and the formation of an acetylated product. Members of this family exhibit substrate specificity, with preferences for amino acids such as L-threoni... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43305"
] | [
"Acetyltransferase_Enz"
] | [
2851
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2,
2186,
628,
35
] | 4 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Family | Acetyltransferase Enzymes | Acetyltransferase Enzymes | Acetyltransferase_Enz | 7 |
IPR052778 | 52,778 | Centrosome-associated WD domain-containing protein | Centrosome-WD_assoc | Family | 4,156 | true | false | This family of proteins is involved in various cellular processes related to centrosome function and ciliogenesis. Members of this family are essential for the proper formation and anchoring of the mitotic spindle to centrosomes during cell division. They are required for the localization of specific centriole satellit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16220"
] | [
"Centrosome-WD_assoc"
] | [
4156
] | 1 | [] | [] | [] | 0 | [
"9qzc",
"9qzf"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
2,
4152,
2
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
2,
7,
3,
2,
2,
5,
1,
6
] | 9 | true | Family | Centrosome-associated WD domain-containing protein | Centrosome-associated WD domain-containing protein | Centrosome-WD_assoc | 4 |
IPR052779 | 52,779 | WD repeat-containing protein 62 | WDR62 | Family | 4,141 | false | false | This family of proteins includes WD repeat-containing protein 62 (WDR62), a microcephaly-related, microtubule (MT)-associated protein (MAP) that localises to the spindle pole and regulates spindle organisation by recruiting katanin to the spindle pole by forming a complex with TPX2/Aurora A [ , ]. It has been suggested... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45589"
] | [
""
] | [
4141
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00073161",
"PUB00073163",
"PUB00076882",
"PUB00155369",
"PUB00155370"
] | [
"20729831",
"20890278",
"26297806",
"34137789",
"34137788"
] | [
"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.",
"Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture.",
"Centriolar satellites assemble centrosomal microcephaly proteins to recruit ... | [
2010,
2010,
2015,
2021,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
3,
4138
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
9,
6,
9,
20,
5,
1,
8
] | 7 | true | Family | WD repeat-containing protein 62 | WD repeat-containing protein 62 | WDR62 | 6 |
IPR052780 | 52,780 | Aromatic Amino Acid Catabolism Transcriptional Regulators | AAA_Catabolism_Regulators | Family | 3,925 | true | false | This family of proteins includes transcriptional activators involved in the regulation of various metabolic processes. Members of this family are responsible for the expression of genes related to the catabolism of aromatic amino acids, such as activating the transcription of aminotransferases and decarboxylases. They ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31644"
] | [
"AAA_Catabolism_Regulators"
] | [
3925
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3925
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Family | Aromatic Amino Acid Catabolism Transcriptional Regulators | Aromatic Amino Acid Catabolism Transcriptional Regulators | AAA_Catabolism_Regulators | 9 |
IPR052782 | 52,782 | Oocyte-to-zygote transition regulator | Oocyte-zygote_transition_reg | Family | 3,783 | true | false | This family of proteins includes inactive phosphatases and pseudophosphatases that are essential for the oocyte-to-zygote transition in Caenorhabditis elegans. Members of this family are involved in the regulation of the cortical actin cytoskeleton's polarization and rearrangement during oocyte maturation and post-fert... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46163"
] | [
"Oocyte-zygote_transition_reg"
] | [
3783
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
3775,
8
] | 2 | [
"Caenorhabditis elegans"
] | [
42
] | 1 | true | Family | Oocyte-to-zygote transition regulator | Oocyte-to-zygote transition regulator | Oocyte-zygote_transition_reg | 8 |
IPR052784 | 52,784 | Perforin-1 pore-forming | Perforin-1_pore-forming | Family | 3,357 | true | false | The Perforin-1 family includes pore-forming proteins that are essential for granzyme-mediated programmed cell death and immune defense against virus-infected or neoplastic cells. Members of the family can insert into target cell membranes when bound to calcium, oligomerize, and form large pores. This action facilitates... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46096"
] | [
"Perforin-1_pore-forming"
] | [
3357
] | 1 | [
"REACTOME"
] | [
"R-HSA-9725371"
] | [
"REACTOME:R-HSA-9725371"
] | 1 | [
"3nsj",
"3w56",
"3w57",
"4y1s",
"4y1t",
"5oup",
"5ouq",
"5own",
"5ug6",
"5ug7",
"7pag"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Klosneuvirinae"
] | [
13,
3341,
3
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
7,
2,
6
] | 4 | true | Family | Perforin-1 pore-forming | Perforin-1 pore-forming | Perforin-1_pore-forming | 6 |
IPR052785 | 52,785 | Enterotoxin complex component | Enterotoxin_cmpnt | Family | 2,306 | true | false | This family of proteins includes components of an enterotoxin complex known for its role in causing gastroenteritis through food-borne pathogens. Members of this family are involved in binding to erythrocytes and are associated with cytotoxic activity, contributing to the diarrheal symptoms observed during infection. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38443"
] | [
"Enterotoxin_cmpnt"
] | [
2306
] | 1 | [] | [] | [] | 0 | [
"2nrj",
"4k1p",
"6dfp",
"6ezv",
"6grj",
"6grk",
"6h2f",
"6tao",
"6w08",
"6zz5",
"6zzh",
"7a0g",
"7nmq",
"7p3r"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2245,
58,
3
] | 3 | [] | [] | 0 | true | Family | Enterotoxin complex component | Enterotoxin complex component | Enterotoxin_cmpnt | 3 |
IPR052786 | 52,786 | Outer_spore_wall_assembly | Spore_wall_assembly | Family | 3,337 | true | false | This family of proteins is involved in the assembly of the spore wall, a critical process in the formation of spores in yeast. Members of this family may also play a role in modulating ribosomal DNA transcription, suggesting a potential regulatory function in addition to their structural role in spore wall formation. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34292"
] | [
"Spore_wall_assembly"
] | [
3337
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
3331,
6
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
3
] | 2 | true | Family | Outer_spore_wall_assembly | Outer_spore_wall_assembly | Spore_wall_assembly | 2 |
IPR052787 | 52,787 | Mitochondrial antiviral-signaling domain-containing protein | MAVS | Family | 3,469 | true | false | This family of proteins serves as an adapter in the innate immune defense against viruses. It operates downstream of sensors that detect viral replication by-products, coordinating the activation of key transcription factors and the induction of antiviral cytokines. The proteins in this family contain domains essential... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21446"
] | [
"MAVS"
] | [
3469
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-168928",
"R-HSA-5689896",
"R-HSA-918233",
"R-HSA-933541",
"R-HSA-933542",
"R-HSA-933543",
"R-HSA-936440",
"R-HSA-9692916",
"R-HSA-9705671",
"R-HSA-9833109",
"R-HSA-9833482",
"R-MMU-168928",
"R-MMU-936440",
"R-MMU-9833482",
"R-RNO-168928",
"R-RNO-936440",
"R-RNO-9833482"
] | [
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-5689896",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-933541",
"REACTOME:R-HSA-933542",
"REACTOME:R-HSA-933543",
"REACTOME:R-HSA-936440",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HSA-9705671",
"REACTOME:R-HSA-9833109",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MM... | 17 | [
"2ms7",
"2ms8",
"4o9f",
"4o9l"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"invertebrate metagenome"
] | [
3468,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
3,
4
] | 4 | true | Family | Mitochondrial antiviral-signaling domain-containing protein | Mitochondrial antiviral-signaling domain-containing protein | MAVS | 5 |
IPR052788 | 52,788 | RING-type E3 ubiquitin ligase ATL | RING-type_E3_ligase_ATL | Family | 3,994 | true | false | This family of proteins includes E3 ubiquitin-protein ligases that exhibit in vitro E3 ligase activity, mediating protein monoubiquitination. Members are involved in plant defense signaling by monoubiquitinating phosphorylated BIK1 in response to pathogen detection. They contain a RING-type zinc finger domain that is r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45798"
] | [
"RING-type_E3_ligase_ATL"
] | [
3994
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5,
3932,
27,
30
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
18,
32,
1,
40
] | 4 | true | Family | RING-type E3 ubiquitin ligase ATL | RING-type E3 ubiquitin ligase ATL | RING-type_E3_ligase_ATL | 6 |
IPR052789 | 52,789 | Protein SSUH2 homolog | SSUH2_homolog | Family | 3,252 | true | true | SSUH2 protein is implicated in the biological process of odontogenesis, which is the complex development of teeth. Members of this family are homologous proteins that share a conserved function across different species, including zebrafish, mice, and humans. The role of the SSUH2 in odontogenesis suggests their involve... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48465"
] | [
""
] | [
3252
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155260"
] | [
"27680507"
] | [
"Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"marine sediment metagenome",
"uncultured marine phage"
] | [
12,
111,
3126,
2,
1
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
4,
10,
3,
2,
2,
4,
5
] | 8 | true | Family | Protein SSUH2 homolog | Protein SSUH2 homolog | SSUH2_homolog | 5 |
IPR052790 | 52,790 | YEATS domain-containing | YEATS_domain | Family | 3,182 | true | false | The YEATS domain-containing protein family is characterized by its ability to recognize and bind acylated histones, particularly those that are crotonylated. Members of this family function as chromatin reader components of the super elongation complex (SEC), which is essential for enhancing the catalytic rate of RNA p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47827"
] | [
"YEATS_domain"
] | [
3182
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-112382",
"R-HSA-674695",
"R-HSA-75955",
"R-MMU-112382",
"R-MMU-674695",
"R-MMU-75955"
] | [
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-674695",
"REACTOME:R-HSA-75955",
"REACTOME:R-MMU-112382",
"REACTOME:R-MMU-674695",
"REACTOME:R-MMU-75955"
] | 6 | [
"2lm0",
"2mv7",
"2n4q",
"2ndf",
"2ndg",
"4tmp",
"5hjb",
"5hjd",
"5j9s",
"5yyf",
"6b7g",
"6hpw",
"6hpx",
"6hpy",
"6hpz",
"6hq0",
"6ht0",
"6ht1",
"6l5z",
"6ls6",
"6mil",
"6mim",
"6t1i",
"6t1j",
"6t1l",
"6t1m",
"6t1n",
"6t1o",
"7b0t",
"7b10",
"7e74",
"7e7a"... | 48 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3182
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
4,
12,
11,
9
] | 5 | true | Family | YEATS domain-containing | YEATS domain-containing | YEATS_domain | 6 |
IPR052791 | 52,791 | SSM1 domain-containing protein | SSM1_domain | Family | 2,756 | true | false | This family of proteins may be involved in cellular processes such as transcription and phosphate metabolism. One member is suggested to have a role in the inactivation of 6-azauracil, which could indicate a function in nucleotide metabolism or detoxification. Another member is implicated in phosphate metabolic process... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47438"
] | [
"SSM1_domain"
] | [
2756
] | 1 | [] | [] | [] | 0 | [
"3nuq",
"3onn",
"3opx"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes",
"unclassified Klosneuvirinae"
] | [
444,
2304,
5,
3
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | SSM1 domain-containing protein | SSM1 domain-containing protein | SSM1_domain | 6 |
IPR052792 | 52,792 | Thioredoxin domain-containing protein 11 | Thioredoxin_dom-contain_11 | Family | 2,718 | true | false | The Thioredoxin domain-containing protein 11 family is part of the protein disulfide isomerase family, suggesting a role in the formation of proper protein disulfide bonds. Members of this family may function as redox regulators, particularly in the folding of Dual Oxidase (DUOX) proteins. They are implicated in the th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46497"
] | [
"Thioredoxin_dom-contain_11"
] | [
2718
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2718
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
1,
4,
7,
6
] | 6 | true | Family | Thioredoxin domain-containing protein 11 | Thioredoxin domain-containing protein 11 | Thioredoxin_dom-contain_11 | 4 |
IPR052793 | 52,793 | Exon junction complex-associated protein | EJC-associated_protein | Family | 2,858 | true | false | This family of proteins includes components of the exon junction complex (EJC), which is involved in mRNA splicing and metabolism. Members of this family are implicated in the regulation of splicing, particularly in the modulation of apoptotic gene isoforms. They are known to bind RNA and are associated with the ASAP c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46589"
] | [
"EJC-associated_protein"
] | [
2858
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-111465",
"R-HSA-72163",
"R-MMU-111465",
"R-MMU-72163"
] | [
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-111465",
"REACTOME:R-MMU-72163"
] | 4 | [
"4a8x",
"6g6s"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"organismal metagenomes"
] | [
15,
2836,
4,
3
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
12,
2,
7,
13,
1,
6
] | 7 | true | Family | Exon junction complex-associated protein | Exon junction complex-associated protein | EJC-associated_protein | 4 |
IPR052794 | 52,794 | Mitochondrial Serine Protease LACTB | Mito_Ser_Protease_LACTB | Family | 1,902 | true | false | The LACTB family comprises mitochondrial serine proteases that regulate mitochondrial lipid metabolism. These enzymes are involved in modulating the levels of PISD, a key enzyme in the conversion of phosphatidylserine to phosphatidylethanolamine, impacting the lipid composition within mitochondria. The precise mechanis... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46520"
] | [
"Mito_Ser_Protease_LACTB"
] | [
1902
] | 1 | [] | [] | [] | 0 | [
"7ulw",
"7v1y",
"7v1z",
"7v21"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
395,
1492,
15
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
7,
3
] | 5 | true | Family | Mitochondrial Serine Protease LACTB | Mitochondrial Serine Protease LACTB | Mito_Ser_Protease_LACTB | 3 |
IPR052795 | 52,795 | Ras-responsive element-binding protein 1 | RREB1 | Family | 2,786 | true | false | The RREB1 family comprises transcription factors that bind specifically to RAS-responsive elements in gene promoters. Members of the family are involved in various cellular processes, including the repression of the angiotensinogen gene, regulation of transcriptional activities of AR and NEUROD1, and promotion of brown... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46451"
] | [
"RREB1"
] | [
2786
] | 1 | [] | [] | [] | 0 | [
"5kkq",
"5t00"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2786
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
4,
6,
2,
3
] | 5 | true | Family | Ras-responsive element-binding protein 1 | Ras-responsive element-binding protein 1 | RREB1 | 7 |
IPR052796 | 52,796 | Nodulation factor sulfotransferase | Nod_factor_sulfotransferase | Family | 2,677 | true | false | This family of proteins is involved in the biosynthesis of nodulation factors, which are key signaling molecules in symbiotic relationships between certain plants and nitrogen-fixing bacteria. Members of this family are believed to participate in the sulfation process of the nod factor by transferring sulfate from 3'-p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32175"
] | [
"Nod_factor_sulfotransferase"
] | [
2677
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.8.2.-",
"PWY-6546",
"PWY-6558",
"PWY-6567",
"PWY-6568",
"PWY-7831",
"PWY-8045",
"PWY-8358",
"PWY-8381"
] | [
"EC:2.8.2.-",
"METACYC:PWY-6546",
"METACYC:PWY-6558",
"METACYC:PWY-6567",
"METACYC:PWY-6568",
"METACYC:PWY-7831",
"METACYC:PWY-8045",
"METACYC:PWY-8358",
"METACYC:PWY-8381"
] | 9 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
244,
2432,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
15,
33
] | 3 | true | Family | Nodulation factor sulfotransferase | Nodulation factor sulfotransferase | Nod_factor_sulfotransferase | 1 |
IPR052797 | 52,797 | Regulatory Factors in Gene Expression and Cell Death | RegFact_GeneExpr_CellDeath | Family | 2,902 | true | false | The protein family in question appears to be involved in regulatory functions within the cell, with one member identified as a probable transcription factor that may influence gene expression by binding to regulatory regions, specifically modulating the expression of homeobox protein lin-39 in the vulval lineage. Anoth... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33936"
] | [
"RegFact_GeneExpr_CellDeath"
] | [
2902
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2902
] | 1 | [
"Caenorhabditis elegans"
] | [
15
] | 1 | true | Family | Regulatory Factors in Gene Expression and Cell Death | Regulatory Factors in Gene Expression and Cell Death | RegFact_GeneExpr_CellDeath | 5 |
IPR052798 | 52,798 | Giardia Variant Surface Antigen | Giardia_VSA | Family | 2,435 | true | false | This family of proteins is characterized by the presence of a CXXC motif repeat, which suggests a potential role in binding to other proteins or possibly to DNA. Members of this family are known as variant surface proteins (VSPs) in Giardia, which indicates that they may be involved in antigenic variation, a mechanism ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23275"
] | [
"Giardia_VSA"
] | [
2435
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ruminococcus bicirculans (ex Wegman et al. 2014)"
] | [
2434,
1
] | 2 | [] | [] | 0 | true | Family | Giardia Variant Surface Antigen | Giardia Variant Surface Antigen | Giardia_VSA | 6 |
IPR052799 | 52,799 | Rho GTPase-activating Regulators | Rho_GAP_Regulators | Family | 2,904 | true | false | This family of proteins includes Rho GTPase-activating proteins (GAPs) that are involved in the regulation of the Rho family of small GTPases, particularly the Rac-type GTPase. Members of this family function by catalyzing the conversion of the active GTP-bound form of these GTPases to their inactive GDP-bound state, t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46265"
] | [
"Rho_GAP_Regulators"
] | [
2904
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
2904
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
18,
170
] | 3 | true | Family | Rho GTPase-activating Regulators | Rho GTPase-activating Regulators | Rho_GAP_Regulators | 4 |
IPR052800 | 52,800 | DNA Repair Helicase ZGRF1 | DNA_Repair_Helicase_ZGRF1 | Family | 2,910 | true | false | This family of proteins includes 5'-3' DNA helicases that are involved in DNA repair processes, particularly in the repair of replication-blocking DNA lesions. They are known to be recruited to sites of DNA damage and enhance homologous recombination (HR) by directly stimulating the strand exchange activity of RAD51. T... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28535"
] | [
"DNA_Repair_Helicase_ZGRF1"
] | [
2910
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2910
] | 1 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
6,
5,
4,
1,
3,
6,
1
] | 7 | true | Family | DNA Repair Helicase ZGRF1 | DNA Repair Helicase ZGRF1 | DNA_Repair_Helicase_ZGRF1 | 4 |
IPR052801 | 52,801 | Ankyrin Repeat and EF-hand Domain-containing | Ankyrin-EF-hand | Family | 1,652 | true | false | The Ankyrin repeat and EF-hand domain-containing protein family is characterized by the presence of ankyrin repeats and EF-hand domains, suggesting a role in calcium signaling and protein-protein interactions. Members of this family, such as Ankyrin repeat domain-containing protein 23, are implicated in energy metaboli... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24127"
] | [
"Ankyrin-EF-hand"
] | [
1652
] | 1 | [] | [] | [] | 0 | [
"9fqr"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"marine sediment metagenome"
] | [
176,
1450,
25,
1
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
3,
2
] | 4 | true | Family | Ankyrin Repeat and EF-hand Domain-containing | Ankyrin Repeat and EF-hand Domain-containing | Ankyrin-EF-hand | 5 |
IPR052802 | 52,802 | Kinetochore-associated protein 1 | KNTC1 | Family | 2,306 | false | false | This entry includes KNTC1 (also known as ROD) proteins, a crucial component of the mitotic checkpoint, ensuring cells do not exit mitosis prematurely [ , , ]. KNTC1 is required for the assembly of essential complexes onto kinetochores, including dynein-dynactin and MAD1-MAD2 in mammals, and dynein-dynactin and mdf-1-md... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15688"
] | [
""
] | [
2306
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-5663220",
"REACTOME:R-MMU-68877",
"REACTOME:R-MM... | 12 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00044470",
"PUB00154939",
"PUB00154940"
] | [
"11146660",
"15824131",
"11590237",
"35373361"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"ZW10 links mitotic checkpoint signaling to the structural kinetochore.",
"The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.",
"Structure of th... | [
2000,
2005,
2001,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2306
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
2,
7,
3,
3
] | 6 | true | Family | Kinetochore-associated protein 1 | Kinetochore-associated protein 1 | KNTC1 | 2 |
IPR052803 | 52,803 | Primary Cilium-Associated Jouberin | Cilium-Associated_Jouberin | Family | 2,154 | true | false | This family of proteins is involved in various cellular processes related to ciliogenesis and vesicle trafficking. They are essential for the formation of primary non-motile cilia and play a role in the recruitment of specific proteins to the basal body of the cilium. These proteins are also components of a complex tha... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44499"
] | [
"Cilium-Associated_Jouberin"
] | [
2154
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [
"4esr"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2154
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
25,
5,
6
] | 4 | true | Family | Primary Cilium-Associated Jouberin | Primary Cilium-Associated Jouberin | Cilium-Associated_Jouberin | 2 |
IPR052805 | 52,805 | GEF and Ubiquitin-Proteasome Regulators | GEF_Ubiquitin-Prot_Reg | Family | 2,163 | true | false | The protein family in question appears to encompass proteins with roles in cellular signaling and regulation. One member, ECT2L_HUMAN, is suggested to function as a guanine nucleotide exchange factor (GEF), which implies a role in activating GTPases, critical for various cellular processes including cell division and d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46857"
] | [
"GEF_Ubiquitin-Prot_Reg"
] | [
2163
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
2156,
7
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
10,
8,
14
] | 4 | true | Family | GEF and Ubiquitin-Proteasome Regulators | GEF and Ubiquitin-Proteasome Regulators | GEF_Ubiquitin-Prot_Reg | 6 |
IPR052806 | 52,806 | Fasciclin-like AGP | Fasciclin-like_AGP | Family | 2,890 | true | false | This family of proteins may function as cell surface adhesion molecules. Members of this family are characterized by their similarity to fasciclin-like arabinogalactan proteins, which are known to play a role in cell-cell interactions and communication. These proteins may be involved in various biological processes whe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33985"
] | [
"Fasciclin-like_AGP"
] | [
2890
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ktedonospora formicarum",
"Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254)"
] | [
2888,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
9,
3
] | 3 | true | Family | Fasciclin-like AGP | Fasciclin-like AGP | Fasciclin-like_AGP | 1 |
IPR052807 | 52,807 | Mitochondrial translation and respiration regulator | Mito_transl_resp_regulator | Family | 1,880 | true | false | This family of proteins is involved in the regulation of mitochondrial protein translation and respiration. Members of this family play a role in mitochondria-mediated cell death and may function as scaffolding proteins or stabilizers of respiratory chain supercomplexes. They have the ability to bind GTP, which suggest... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46406"
] | [
"Mito_transl_resp_regulator"
] | [
1880
] | 1 | [] | [] | [] | 0 | [
"8csp",
"9g5b"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
110,
1770
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
1,
2,
2,
5
] | 6 | true | Family | Mitochondrial translation and respiration regulator | Mitochondrial translation and respiration regulator | Mito_transl_resp_regulator | 6 |
IPR052808 | 52,808 | G-protein coupled receptor Mth-like | GPCR_Mth-like | Family | 2,291 | true | false | This family of proteins includes G-protein coupled receptors (GPCRs) that are likely involved in signal transduction processes. GPCRs are a large family of cell surface receptors that respond to a variety of external signals and activate intracellular signaling pathways through the binding and activation of G-proteins.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46953"
] | [
"GPCR_Mth-like"
] | [
2291
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Betaentomopoxvirus",
"Eumetazoa"
] | [
2,
2289
] | 2 | [
"Drosophila melanogaster"
] | [
6
] | 1 | true | Family | G-protein coupled receptor Mth-like | G-protein coupled receptor Mth-like | GPCR_Mth-like | 3 |
IPR052809 | 52,809 | Actin-polarity regulatory | Actin_polarity_regulatory | Family | 2,018 | true | false | This family of proteins is involved in the regulation of cellular polarity and actin cytoskeleton organization. Members of this family play a crucial role in the spatial orientation of cell growth and division. They are essential for the proper localization of specific proteins to the plasma membrane, which is a key fa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28245"
] | [
"Actin_polarity_regulatory"
] | [
2018
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2018
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Actin-polarity regulatory | Actin-polarity regulatory | Actin_polarity_regulatory | 9 |
IPR052810 | 52,810 | Plant N-acetyltransferase | Plant_NAT | Family | 2,525 | true | false | This family of proteins includes N-acetyltransferases that play a role in plant development and growth. Members are involved in processes such as cell elongation, apical hook formation in seedlings, and auxin homeostasis, which may influence organogenesis and plant biomass. Some family members exhibit histone acetyltra... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47370"
] | [
"Plant_NAT"
] | [
2525
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2525
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
15,
25
] | 3 | true | Family | Plant N-acetyltransferase | Plant N-acetyltransferase | Plant_NAT | 1 |
IPR052811 | 52,811 | Glucose-responsive signaling protein | Glucose_resp_signaling | Family | 2,050 | true | false | This family of proteins includes members involved in signal transduction pathways, particularly in the response to glucose availability. One characterized member functions in the glucose/cAMP-signaling pathway, which is essential for maintaining basal levels of cAMP and generating a glucose-induced cAMP response. The f... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47263"
] | [
"Glucose_resp_signaling"
] | [
2050
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2050
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2
] | 3 | true | Family | Glucose-responsive signaling protein | Glucose-responsive signaling protein | Glucose_resp_signaling | 3 |
IPR052813 | 52,813 | C-Maf-inducing protein | CMIP | Family | 1,887 | true | false | This family of proteins is involved in the signaling pathways of T-cells. Members of this family are implicated in the transmission of signals that lead to the activation of specific transcription factors, such as c-Maf, which is associated with the differentiation of T-helper 2 (Th2) cells. The proteins may have disti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR25480"
] | [
"CMIP"
] | [
1887
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1887
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2,
4
] | 4 | true | Family | C-Maf-inducing protein | C-Maf-inducing protein | CMIP | 5 |
IPR052814 | 52,814 | Peroxisomal Protein Import DnaJ | Peroxisomal_DnaJ | Family | 1,943 | true | false | The DnaJ protein family is involved in the molecular chaperone system, which is essential for protein folding and quality control within the cell. Members of this family, such as DnaJ-like protein 1, are known to play a crucial role in peroxisomal protein import, ensuring the proper function of peroxisomes. Peroxisomes... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45006"
] | [
"Peroxisomal_DnaJ"
] | [
1943
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natrinema salaciae",
"ecological metagenomes"
] | [
8,
1932,
1,
2
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | Peroxisomal Protein Import DnaJ | Peroxisomal Protein Import DnaJ | Peroxisomal_DnaJ | 4 |
IPR052815 | 52,815 | Programmed cell death 2-like regulator | PDCD2-like_regulator | Family | 1,878 | true | false | This family of proteins is implicated in the regulation of transcriptional activation and cell cycle progression. Members of this family are known to suppress the activity of several transcription factors, including AP1, CREB, NFAT, and NF-kB, which are critical for various cellular processes. Additionally, these prote... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46421"
] | [
"PDCD2-like_regulator"
] | [
1878
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1878
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
4,
2,
2
] | 5 | true | Family | Programmed cell death 2-like regulator | Programmed cell death 2-like regulator | PDCD2-like_regulator | 1 |
IPR052816 | 52,816 | Peroxisomal Membrane Protein PEX28-32 | Peroxisomal_Membrane_PEX28-32 | Family | 1,871 | true | false | The PEX28-32 family is involved in the regulation of peroxisome number, size, and distribution within the cell. Members of this family are peroxisomal membrane proteins that play a role in peroxisome maintenance and dynamics. The family includes subfamilies such as PEX28 and PEX29, which share similar functions in pero... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28304"
] | [
"Peroxisomal_Membrane_PEX28-32"
] | [
1871
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1871
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | Peroxisomal Membrane Protein PEX28-32 | Peroxisomal Membrane Protein PEX28-32 | Peroxisomal_Membrane_PEX28-32 | 2 |
IPR052817 | 52,817 | MIT domain-containing protein 1 | MIT_domain_contain_protein1 | Family | 1,661 | true | false | The MIT domain-containing protein 1 family is involved in the final stages of cell division, specifically in the abscission process that completes cytokinesis. Members of this family possess a MIT domain that interacts with the MIT-interacting motifs of ESCRT-III complex components, playing a crucial role in the separa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21222"
] | [
"MIT_domain_contain_protein1"
] | [
1661
] | 1 | [] | [] | [] | 0 | [
"2ymb",
"4a5z"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"uncultured Caudovirales phage"
] | [
111,
1549,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
6,
3,
1,
2
] | 6 | true | Family | MIT domain-containing protein 1 | MIT domain-containing protein 1 | MIT_domain_contain_protein1 | 6 |
IPR052818 | 52,818 | NEDD1 Spindle Assembly Protein | NEDD1_Spindle_Assembly | Family | 1,917 | true | false | This family of proteins is essential for the progression of mitosis, a critical phase of the cell cycle. Members of this family facilitate the nucleation of microtubules from the spindle, which is a key step in the formation of the mitotic spindle required for chromosome segregation. Additionally, these proteins may ha... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44414"
] | [
"NEDD1_Spindle_Assembly"
] | [
1917
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2565942",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5620912",
"R-BTA-8854518",
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-... | [
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BTA-5620912",
"REACTOME:R-BTA-8854518",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA... | 21 | [
"9i8m",
"9i8n",
"9qvm",
"9qvn"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aphanothece sacrum FPU1",
"Eukaryota"
] | [
1,
1916
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
9,
2,
6
] | 5 | true | Family | NEDD1 Spindle Assembly Protein | NEDD1 Spindle Assembly Protein | NEDD1_Spindle_Assembly | 7 |
IPR052819 | 52,819 | Chromatin-associated regulatory protein | Chromatin_regulatory_protein | Family | 1,894 | true | false | This family of proteins includes components involved in the regulation of gene expression through the modification of chromatin structure. Specifically, one member is known to function as a catalytic component of a histone deacetylase complex, which is responsible for the removal of acetyl groups from lysine residues o... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47636"
] | [
"Chromatin_regulatory_protein"
] | [
1894
] | 1 | [] | [] | [] | 0 | [
"7yi0",
"7yi2",
"7yi3",
"7yi4",
"7yi5",
"8hxx",
"8hxy",
"8hy0",
"8i02",
"8i3f",
"8ifg",
"8ihn",
"8iht",
"8jho",
"8kc7",
"8kd2",
"8kd3",
"8kd4",
"8kd5",
"8kd6",
"8kd7",
"8tof",
"8w9c",
"8w9d",
"8w9e",
"8w9f"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1894
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
2
] | 3 | true | Family | Chromatin-associated regulatory protein | Chromatin-associated regulatory protein | Chromatin_regulatory_protein | 2 |
IPR052820 | 52,820 | PhiA domain-containing protein | PhiA_domain | Family | 1,765 | true | false | This family of proteins is involved in the development of asexual reproductive structures in fungi, specifically in the formation of phialides and conidia, which are essential for spore production. Members of this family also serve as a general stress protectant for the fungus, particularly in competitive interactions ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42047"
] | [
"PhiA_domain"
] | [
1765
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1765
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Zea mays"
] | [
1,
1
] | 2 | true | Family | PhiA domain-containing protein | PhiA domain-containing protein | PhiA_domain | 1 |
IPR052821 | 52,821 | F-box only substrate-recognition component | F-box_only_SRC | Family | 1,800 | true | false | This family of proteins serves as substrate-recognition components within SCF-type E3 ubiquitin ligase complexes. They are involved in the targeted ubiquitination and subsequent proteasomal degradation of specific proteins, notably the tumor suppressor p53. By recognizing and binding to p53, they facilitate its ubiquit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46432"
] | [
"F-box_only_SRC"
] | [
1800
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1800
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2,
7,
4
] | 6 | true | Family | F-box only substrate-recognition component | F-box only substrate-recognition component | F-box_only_SRC | 1 |
IPR052823 | 52,823 | SXP/RAL-2-related | SXP/RAL-2_related | Family | 1,713 | true | false | This family of proteins is characterized by similarity to the SXP/RAL-2 family, which suggests a potential role in a variety of biological processes. Members of the SXP/RAL-2 family are often involved in host-parasite interactions, with some functioning as antigens in parasitic organisms. These proteins may be implicat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21593"
] | [
"SXP/RAL-2_related"
] | [
1713
] | 1 | [] | [] | [] | 0 | [
"2mar"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
1713
] | 1 | [
"Caenorhabditis elegans"
] | [
41
] | 1 | true | Family | SXP/RAL-2-related | SXP/RAL-2-related | SXP/RAL-2_related | 1 |
IPR052824 | 52,824 | N6-methyladenosine RNA Methylation Regulator | m6A_RNA_Methylation_Regulator | Family | 1,764 | true | false | This family of proteins includes components involved in the post-transcriptional modification of RNA, specifically through N6-methyladenosine (m6A) methylation. Members of this family play a crucial role in the efficiency of mRNA splicing and RNA processing. They are key regulators of m6A methylation, particularly infl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13585"
] | [
"m6A_RNA_Methylation_Regulator"
] | [
1764
] | 1 | [] | [] | [] | 0 | [
"7vf2"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Hokovirus HKV1",
"viral metagenome"
] | [
7,
1754,
2,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
4,
7,
7,
5,
2,
4,
4,
1
] | 9 | true | Family | N6-methyladenosine RNA Methylation Regulator | N6-methyladenosine RNA Methylation Regulator | m6A_RNA_Methylation_Regulator | 3 |
IPR052825 | 52,825 | Coiled-coil domain-containing protein Prefoldin subunit beta-like | CCD-Prefoldin_beta-like | Family | 1,862 | true | false | This family of proteins is characterized by the presence of a coiled-coil domain, which suggests a role in providing structural support and facilitating protein-protein interactions. Members of this family are similar to the prefoldin subunit beta, indicating a potential involvement in the stabilization of nascent poly... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34479"
] | [
"CCD-Prefoldin_beta-like"
] | [
1862
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1862
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
25,
25,
17,
10
] | 4 | true | Family | Coiled-coil domain-containing protein Prefoldin subunit beta-like | Coiled-coil domain-containing protein Prefoldin subunit beta-like | CCD-Prefoldin_beta-like | 9 |
IPR052827 | 52,827 | Chitin Synthase Export/Cell Fusion Regulator | CHS_Export/Cell_Fusion_Reg | Family | 1,732 | true | false | This family of proteins is involved in various cellular processes related to the synthesis of chitin and cell fusion. Members of this family are known to form complexes that facilitate the export of specific cargo proteins, such as chitin synthase, to their proper cellular locations. Additionally, they play a role in t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47351"
] | [
"CHS_Export/Cell_Fusion_Reg"
] | [
1732
] | 1 | [] | [] | [] | 0 | [
"4in3",
"4q66",
"4wjw",
"4yg8"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1732
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Chitin Synthase Export/Cell Fusion Regulator | Chitin Synthase Export/Cell Fusion Regulator | CHS_Export/Cell_Fusion_Reg | 9 |
IPR052828 | 52,828 | Negative elongation factor A domain-containing protein | NELF-A_domain | Family | 2,116 | true | false | This family of proteins is involved in the regulation of transcription elongation by RNA polymerase II. Members of this family are essential components of the NELF complex, which interacts with the DSIF complex to induce transcriptional pausing. This action is antagonized by the P-TEFb kinase complex. The presence of a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13328"
] | [
"NELF-A_domain"
] | [
2116
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-112382",
"R-DME-113418",
"R-DME-674695",
"R-DME-6796648",
"R-DME-75955",
"R-HSA-112382",
"R-HSA-113418",
"R-HSA-167152",
"R-HSA-167158",
"R-HSA-167200",
"R-HSA-167238",
"R-HSA-167242",
"R-HSA-167243",
"R-HSA-167246",
"R-HSA-167287",
"R-HSA-167290",
"R-HSA-674695",
"R-HSA-679... | [
"REACTOME:R-DME-112382",
"REACTOME:R-DME-113418",
"REACTOME:R-DME-674695",
"REACTOME:R-DME-6796648",
"REACTOME:R-DME-75955",
"REACTOME:R-HSA-112382",
"REACTOME:R-HSA-113418",
"REACTOME:R-HSA-167152",
"REACTOME:R-HSA-167158",
"REACTOME:R-HSA-167200",
"REACTOME:R-HSA-167238",
"REACTOME:R-HSA-167... | 24 | [
"5l3x",
"6gml",
"7pks",
"7ycx",
"8rbx",
"8uha",
"8uhd",
"8uhg",
"8ui0",
"8uis",
"8w8e",
"9j0n",
"9j0o",
"9j0p",
"9vd9"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
70,
2022,
20,
4
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
4,
14,
2,
2,
1
] | 6 | true | Family | Negative elongation factor A domain-containing protein | Negative elongation factor A domain-containing protein | NELF-A_domain | 7 |
IPR052829 | 52,829 | N-acetyltransferase domain-containing protein | N-acetyltransferase_domain | Family | 1,270 | true | false | This family of proteins includes enzymes that are involved in the transfer of acetyl groups from acetyl-CoA to various substrates. Members of this family are typically referred to as N-acetyltransferases and are known to play a role in the modification of small molecules, proteins, and other macromolecules. This modifi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43259"
] | [
"N-acetyltransferase_domain"
] | [
1270
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"1on0",
"1ufh",
"4m85"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Evosea",
"Methanobacteriati",
"Viruses",
"metagenomes"
] | [
1239,
16,
5,
2,
8
] | 5 | [] | [] | 0 | true | Family | N-acetyltransferase domain-containing protein | N-acetyltransferase domain-containing protein | N-acetyltransferase_domain | 4 |
IPR052831 | 52,831 | Apoptosis-promoting protein | Apoptosis_promoter | Family | 1,856 | true | false | This family of proteins is involved in the regulation of programmed cell death or apoptosis. Members of this family have been shown to promote apoptosis when they are overexpressed. Apoptosis is a critical process in development and homeostasis in multicellular organisms, allowing the body to remove unwanted or damaged... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48190"
] | [
"Apoptosis_promoter"
] | [
1856
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-72165",
"R-MMU-72165"
] | [
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72165"
] | 2 | [
"8r7n",
"8y6o",
"9gbw",
"9gc0",
"9gcm"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1856
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
5,
4,
4,
5,
10
] | 7 | true | Family | Apoptosis-promoting protein | Apoptosis-promoting protein | Apoptosis_promoter | 8 |
IPR052832 | 52,832 | Starch-Associated Glucan Phosphatase | Starch-Glucan_Phosphatase | Family | 1,720 | true | false | This family of proteins includes phosphoglucan phosphatases that are associated with starch granules and are involved in starch metabolism. Members of this family function to dephosphorylate phospho-oligosaccharides that accumulate during the night, playing a role in the regulation of starch degradation. These enzymes ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46642"
] | [
"Starch-Glucan_Phosphatase"
] | [
1720
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.3.-",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119",
"PWY-7321",
"PWY-7531",
"PWY-7771... | [
"EC:3.1.3.-",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACYC:PWY-6686",
"METACYC:PWY-6720",
"METACYC:PWY-6... | 36 | [
"3nme",
"4kyq",
"4kyr",
"4pyh"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)",
"Eukaryota",
"metagenome"
] | [
9,
1,
1709,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
15,
17
] | 3 | true | Family | Starch-Associated Glucan Phosphatase | Starch-Associated Glucan Phosphatase | Starch-Glucan_Phosphatase | 3 |
IPR052833 | 52,833 | Telomeric DNA-binding and transcriptional regulator | Telomeric_DNA-bd_trans-reg | Family | 1,555 | true | false | This family of proteins is involved in telomere maintenance and gene expression regulation. Members bind to specific telomeric DNA sequences and can act as transcriptional regulators. They play a role in regulating telomere length, either by promoting or inhibiting telomere elongation. Additionally, these proteins are ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47807"
] | [
"Telomeric_DNA-bd_trans-reg"
] | [
1555
] | 1 | [] | [] | [] | 0 | [
"6k5s",
"6k5u",
"8x6d",
"8x6e",
"8ynu"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1555
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Telomeric DNA-binding and transcriptional regulator | Telomeric DNA-binding and transcriptional regulator | Telomeric_DNA-bd_trans-reg | 8 |
IPR052834 | 52,834 | 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase | 3KSR/17beta-HSD | Family | 1,469 | true | false | This family of proteins is involved in steroid-hormone metabolism and cholesterol biosynthesis. Members of this family function as bifunctional enzymes that catalyze the NADP(H)-dependent reduction of estrogens and androgens, thereby regulating the biological potency of these steroids. They are responsible for converti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44442"
] | [
"3KSR/17beta-HSD"
] | [
1469
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1.210",
"1.1.1.270",
"1.1.1.62",
"PWY-2541",
"PWY-6074",
"PWY-8026",
"PWY-8191",
"PWY-8200",
"PWY-8238",
"PWY-8239",
"R-HSA-191273",
"R-HSA-6807062",
"R-MMU-191273",
"R-MMU-6807062",
"R-RNO-191273",
"R-RNO-6807062"
] | [
"EC:1.1.1.210",
"EC:1.1.1.270",
"EC:1.1.1.62",
"METACYC:PWY-2541",
"METACYC:PWY-6074",
"METACYC:PWY-8026",
"METACYC:PWY-8191",
"METACYC:PWY-8200",
"METACYC:PWY-8238",
"METACYC:PWY-8239",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-6807062",
"REACTOME:R-MMU-191273",
"REACTOME:R-MMU-6807062",
... | 16 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Acholeplasma hippikon",
"Eukaryota"
] | [
1,
1468
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
10,
2,
6
] | 4 | true | Family | 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase | 3-Keto-Steroid Reductase/17-beta-Hydroxysteroid Dehydrogenase | 3KSR/17beta-HSD | 7 |
IPR052835 | 52,835 | Nucleolus and neural progenitor protein | Nepro | Family | 1,498 | false | false | This family includes Nucleolus and neural progenitor protein from mouse (Nepro) and similar animal sequences. Nepro may play a role in cortex development as part of the Notch signalling pathway. Downstream of Notch, it may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintainin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34761"
] | [
""
] | [
1498
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00101272",
"PUB00101273",
"PUB00101274",
"PUB00160952"
] | [
"19906856",
"26178919",
"31250547",
"40413743"
] | [
"Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch.",
"Nepro is localized in the nucleolus and essential for preimplantation development in mice.",
"An emerging ribosomopathy affecting the skeleton due to biallelic variations in NEPRO.",
"Ide... | [
2009,
2015,
2019,
2025
] | 4 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1498
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
12,
4,
4
] | 5 | true | Family | Nucleolus and neural progenitor protein | Nucleolus and neural progenitor protein | Nepro | 2 |
IPR052836 | 52,836 | Proline-rich transmembrane domain-containing protein | PRRT_domain-containing | Family | 1,618 | true | false | This family of proteins is characterized by a proline-rich region and transmembrane domains, suggesting a role in cell adhesion, signaling, or as structural components of the cell membrane. The exact biological functions of these proteins may vary across different tissues and organisms. They could be involved in the fo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35578"
] | [
"PRRT_domain-containing"
] | [
1618
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
1616
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
3,
1,
1
] | 5 | true | Family | Proline-rich transmembrane domain-containing protein | Proline-rich transmembrane domain-containing protein | PRRT_domain-containing | 5 |
IPR052837 | 52,837 | Mitochondrial ribosomal protein bS21 | Mitoribosomal_bS21 | Family | 1,401 | true | false | This family of proteins includes components of the mitochondrial ribosome, also known as mitoribosomes. These proteins are integral to the mitoribosome's structure and function, which is specialized for the synthesis of proteins encoded by the mitochondrial genome. Some of these proteins are essential for the formation... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR41237"
] | [
"Mitoribosomal_bS21"
] | [
1401
] | 1 | [] | [] | [] | 0 | [
"5mrc",
"5mre",
"5mrf",
"6yw5",
"6ywe",
"6ywx",
"6ywy",
"8d8k",
"8d8l",
"8om2",
"8om3",
"8om4"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1401
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Mitochondrial ribosomal protein bS21 | Mitochondrial ribosomal protein bS21 | Mitoribosomal_bS21 | 4 |
IPR052838 | 52,838 | Unconventional myosin-XVI | Myosin-XVI | Family | 1,462 | true | false | This family of proteins includes unconventional myosins with ATPase activity, which are involved in intracellular movements. Members of this family interact with actin filaments and are thought to transport membranous compartments within cells. They play a role in brain development by targeting the catalytic subunit of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47335"
] | [
"Myosin-XVI"
] | [
1462
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1462
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
4,
4,
8
] | 4 | true | Family | Unconventional myosin-XVI | Unconventional myosin-XVI | Myosin-XVI | 2 |
IPR052839 | 52,839 | Mitochondrial gene expression regulator | Mito_gene_expr_regulator | Family | 1,283 | true | false | This family of proteins is involved in mitochondrial biogenesis and the regulation of mitochondrial gene expression. Members of this family are thought to play a role in the assembly of the mitochondrial respiratory chain, particularly influencing the synthesis and stability of cytochrome c oxidase (COX). They may act ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46920"
] | [
"Mito_gene_expr_regulator"
] | [
1283
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1283
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2
] | 4 | true | Family | Mitochondrial gene expression regulator | Mitochondrial gene expression regulator | Mito_gene_expr_regulator | 2 |
IPR052841 | 52,841 | Pyridoxamine phosphate oxidase-like | PMP_oxidase-like | Family | 1,292 | true | false | This family of proteins includes enzymes that are involved in the biosynthesis of vitamin B6, which is an essential cofactor for a wide range of enzymatic reactions. Members of this family catalyze the oxidation of pyridoxamine 5'-phosphate (PMP) to pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. The react... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28040"
] | [
"PMP_oxidase-like"
] | [
1292
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
16,
1276
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Family | Pyridoxamine phosphate oxidase-like | Pyridoxamine phosphate oxidase-like | PMP_oxidase-like | 1 |
IPR052842 | 52,842 | Endoplasmic Reticulum Co-molecular Chaperone | ER_Co-chaperone | Family | 1,386 | true | false | This family of proteins is involved in the regulation of protein folding within the endoplasmic reticulum. Members of this family are thought to act as co-molecular chaperones, assisting in the proper folding of proteins under various conditions, including high-temperature stress. This function is critical for maintain... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45184"
] | [
"ER_Co-chaperone"
] | [
1386
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Zobellia galactanivorans (strain DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij)"
] | [
1385,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
2,
1,
11
] | 4 | true | Family | Endoplasmic Reticulum Co-molecular Chaperone | Endoplasmic Reticulum Co-molecular Chaperone | ER_Co-chaperone | 3 |
IPR052843 | 52,843 | ER body metal ion sequestration protein | ER_body_metal_sequester | Family | 1,678 | true | false | This family of proteins may play a role in the sequestration of excess cytosolic iron and manganese into the endoplasmic reticulum, potentially reducing metal ion toxicity. These proteins are not essential for the accumulation of endoplasmic reticulum body components, including the protein PYK10. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38937"
] | [
"ER_body_metal_sequester"
] | [
1678
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1678
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
35,
4,
4
] | 3 | true | Family | ER body metal ion sequestration protein | ER body metal ion sequestration protein | ER_body_metal_sequester | 5 |
IPR052844 | 52,844 | Leaf Development Regulator | Leaf_Dev_Regulator | Family | 1,391 | true | false | This family of proteins functions as transcription factors involved in cell differentiation. They play a crucial role in leaf development and morphogenesis by regulating the expression of knox homeobox genes and other determinants of leaf polarity. Members of this family can form dimers through a conserved C-terminal d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47214"
] | [
"Leaf_Dev_Regulator"
] | [
1391
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1391
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
4,
3
] | 3 | true | Family | Leaf Development Regulator | Leaf Development Regulator | Leaf_Dev_Regulator | 1 |
IPR052845 | 52,845 | Axonemal dynein light chain domain-containing protein | Axonemal_dynein_LC_domain | Family | 1,175 | true | false | This family of proteins is implicated in the process of spermiogenesis and is considered crucial for male fertility. Members of this family are believed to play a role in the dynamics of the manchette, a structure involved in shaping the spermatid head, as well as in the assembly of the sperm flagellum, which is essent... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23052"
] | [
"Axonemal_dynein_LC_domain"
] | [
1175
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1175
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
7,
3
] | 4 | true | Family | Axonemal dynein light chain domain-containing protein | Axonemal dynein light chain domain-containing protein | Axonemal_dynein_LC_domain | 9 |
IPR052847 | 52,847 | Extended Synaptotagmin & KAHRP-like protein | Ext_Synaptotagmin/KAHRP-like | Family | 1,406 | true | false | This family of proteins includes members that are involved in cellular interactions and signaling processes. Some proteins in this family are thought to mimic human histidine-rich glycoproteins to facilitate the anchoring of binding complexes with endothelial cell receptors. These interactions are critical in the estab... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47042"
] | [
"Ext_Synaptotagmin/KAHRP-like"
] | [
1406
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1406
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
6,
18
] | 3 | true | Family | Extended Synaptotagmin & KAHRP-like protein | Extended Synaptotagmin & KAHRP-like protein | Ext_Synaptotagmin/KAHRP-like | 9 |
IPR052848 | 52,848 | Coiled-coil-helix-coiled-coil-helix domain-containing protein | CHCH_domain-containing_protein | Family | 1,111 | true | false | This family of proteins includes members that are characterized by the presence of a coiled-coil-helix-coiled-coil-helix (CHCH) domain. These proteins are typically involved in mitochondrial functions, particularly in the mitochondrial intermembrane space. They may play roles in mitochondrial dynamics, including the re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47106"
] | [
"CHCH_domain-containing_protein"
] | [
1111
] | 1 | [
"REACTOME"
] | [
"R-HSA-1268020"
] | [
"REACTOME:R-HSA-1268020"
] | 1 | [
"2lql"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1111
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
4,
2,
6,
1
] | 5 | true | Family | Coiled-coil-helix-coiled-coil-helix domain-containing protein | Coiled-coil-helix-coiled-coil-helix domain-containing protein | CHCH_domain-containing_protein | 9 |
IPR052849 | 52,849 | MORN repeat-containing protein | MORN_repeat_protein | Family | 1,082 | true | false | This family of proteins contains MORN repeat motifs and is suggested to play a role in the process of spermatogenesis. The MORN motif, which stands for Membrane Occupation and Recognition Nexus, is typically involved in membrane binding and recognition. Proteins with MORN repeats are implicated in various cellular proc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46917"
] | [
"MORN_repeat_protein"
] | [
1082
] | 1 | [] | [] | [] | 0 | [
"7n6g",
"7sqc",
"9ijj"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
1074
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2,
3
] | 4 | true | Family | MORN repeat-containing protein | MORN repeat-containing protein | MORN_repeat_protein | 5 |
IPR052850 | 52,850 | NPAT LisH domain-containing protein | NPAT_LisH | Family | 1,039 | true | false | This family of proteins is involved in cell cycle regulation, specifically required for the progression through the G1 and S phases and for S phase entry. Members of this family are known to activate transcription of histone genes, including those for histone H2A, H2B, H3, and H4, which are essential for DNA packaging ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15087"
] | [
"NPAT_LisH"
] | [
1039
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1039
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
3
] | 4 | true | Family | NPAT LisH domain-containing protein | NPAT LisH domain-containing protein | NPAT_LisH | 4 |
IPR052851 | 52,851 | GAMETE CELL DEFECTIVE 1 mitochondrial | GCD1_mitochondrial | Family | 1,350 | true | false | The GAMETE CELL DEFECTIVE 1 family proteins are mitochondrial-associated factors essential for plant fertility, playing a critical role in both male and female gametophyte functions and development. They ensure the integrity of female gametic mitochondria and are involved in various developmental processes such as embr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35476"
] | [
"GCD1_mitochondrial"
] | [
1350
] | 1 | [] | [] | [] | 0 | [
"6xyw",
"7pkq",
"8a22",
"8apn",
"8apo",
"9evs",
"9gyt"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1350
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
5,
13
] | 3 | true | Family | GAMETE CELL DEFECTIVE 1 mitochondrial | GAMETE CELL DEFECTIVE 1 mitochondrial | GCD1_mitochondrial | 7 |
IPR052852 | 52,852 | SSU Processome Component | SSU_Processome_Comp | Family | 1,025 | true | false | This family of proteins is involved in the early stages of ribosome biogenesis, specifically in the assembly of the small subunit (SSU) processome. These proteins are found in the nucleolus and are associated with the nascent pre-ribosomal RNA. They collaborate with ribosome biogenesis factors, an RNA chaperone, and ri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28366"
] | [
"SSU_Processome_Comp"
] | [
1025
] | 1 | [] | [] | [] | 0 | [
"7mq8",
"7mq9"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1025
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
3,
2
] | 5 | true | Family | SSU Processome Component | SSU Processome Component | SSU_Processome_Comp | 9 |
IPR052854 | 52,854 | Nematode Serpentine Receptor Class Epsilon | Serpentine_rcpt_epsilon | Family | 1,014 | true | false | This family of proteins includes members that are characterized as serpentine receptors, which are likely to function as G protein-coupled receptors (GPCRs). These receptors typically have a seven-transmembrane domain structure and are involved in signal transduction processes. They are known to play roles in various p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47518"
] | [
"Serpentine_rcpt_epsilon"
] | [
1014
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
1014
] | 1 | [
"Caenorhabditis elegans"
] | [
24
] | 1 | true | Family | Nematode Serpentine Receptor Class Epsilon | Nematode Serpentine Receptor Class Epsilon | Serpentine_rcpt_epsilon | 3 |
IPR052855 | 52,855 | Cytoskeleton-associated protein 2-like | CKAP2-like | Family | 937 | true | false | This family of proteins is involved in the organization and stability of the cytoskeleton, specifically through association with microtubules. Members of this family play a crucial role in the formation of the mitotic spindle, which is essential for proper chromosome segregation during cell division. They are also impo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47078"
] | [
"CKAP2-like"
] | [
937
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
937
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
2,
1,
2
] | 4 | true | Family | Cytoskeleton-associated protein 2-like | Cytoskeleton-associated protein 2-like | CKAP2-like | 6 |
IPR052856 | 52,856 | SOX30 Transcription Factor | SOX30_TF | Family | 868 | true | false | The SOX30 family of transcription factors is characterized by its dual role in gene regulation, functioning as both an activator and a repressor. Members of the SOX30 family recognize and bind to a specific DNA sequence motif, predominantly favoring guanine-rich regions adjacent to the core 5'-ACAAT-3' sequence. The fa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47279"
] | [
"SOX30_TF"
] | [
868
] | 1 | [] | [] | [] | 0 | [
"7jjk"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
868
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Family | SOX30 Transcription Factor | SOX30 Transcription Factor | SOX30_TF | 7 |
IPR052858 | 52,858 | Putative E3 ubiquitin-protein ligase LIN | E3_ubiquitin-ligase_LIN | Family | 1,161 | true | false | This family of proteins includes putative E3 ubiquitin-protein ligases that are implicated in the rhizobial infection process. Members of this family are believed to play a crucial role in the formation of infection threads, as well as in the growth, differentiation, and maintenance of nodules during the symbiotic inte... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47446"
] | [
"E3_ubiquitin-ligase_LIN"
] | [
1161
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
1157
] | 2 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
4
] | 2 | true | Family | Putative E3 ubiquitin-protein ligase LIN | Putative E3 ubiquitin-protein ligase LIN | E3_ubiquitin-ligase_LIN | 3 |
IPR052859 | 52,859 | Leucine-rich repeat and IQ domain-containing protein | LRR-IQ_domain_protein | Family | 792 | true | false | This family of proteins contains leucine-rich repeat (LRR) and IQ motifs, which are typically involved in protein-protein interactions and mediating complex formation. The LRR domains are known for their role in the immune response, cell adhesion, and signal transduction, due to their structural versatility and ability... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46723"
] | [
"LRR-IQ_domain_protein"
] | [
792
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Spirosoma oryzae"
] | [
791,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2,
7
] | 4 | true | Family | Leucine-rich repeat and IQ domain-containing protein | Leucine-rich repeat and IQ domain-containing protein | LRR-IQ_domain_protein | 2 |
IPR052860 | 52,860 | Nematode Receptor-Like/GPCR1 | NRL-GPCR1 | Family | 837 | true | false | This family of proteins includes receptors that are typically involved in signal transduction processes. They are characterized by their ability to bind ligands and initiate a cellular response, commonly through the activation of G-proteins. These receptors are integral membrane proteins that may play a role in various... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47521"
] | [
"NRL-GPCR1"
] | [
837
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
837
] | 1 | [
"Caenorhabditis elegans"
] | [
8
] | 1 | true | Family | Nematode Receptor-Like/GPCR1 | Nematode Receptor-Like/GPCR1 | NRL-GPCR1 | 1 |
IPR052861 | 52,861 | BPTI/Kunitz domain-containing protein | BPTI/Kunitz_domain | Family | 710 | true | false | This family of proteins includes inhibitors that possess a BPTI/Kunitz domain, which is known for its role in protease inhibition. Members of this family are involved in various biological processes, including the regulation of proteolytic pathways, such as those involved in blood coagulation, fibrinolysis, and inflamm... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47248"
] | [
"BPTI/Kunitz_domain"
] | [
710
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
710
] | 1 | [
"Caenorhabditis elegans"
] | [
11
] | 1 | true | Family | BPTI/Kunitz domain-containing protein | BPTI/Kunitz domain-containing protein | BPTI/Kunitz_domain | 3 |
IPR052862 | 52,862 | Tumor necrosis factor receptor superfamily member 8 | TNFR_superfamily_member_8 | Family | 703 | true | false | This family of proteins includes receptors that interact with TNFSF8/CD30L. Members are involved in the regulation of cellular growth and the transformation of activated lymphoblasts. They also play a role in gene expression regulation through the activation of the NF-kappa-B pathway. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47497"
] | [
"TNFR_superfamily_member_8"
] | [
703
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034",
"R-RNO-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034",
"REACTOME:R-RNO-5669034"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Chordopoxvirinae"
] | [
667,
36
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
4
] | 3 | true | Family | Tumor necrosis factor receptor superfamily member 8 | Tumor necrosis factor receptor superfamily member 8 | TNFR_superfamily_member_8 | 2 |
IPR052863 | 52,863 | Ribonuclease H2 subunit C | RNase_H2_subunit_C | Family | 704 | true | false | The RNase H2 subunit C family comprises non-catalytic subunits of the RNase H2 complex, an endonuclease that degrades RNA in RNA:DNA hybrids. The family plays a crucial role in DNA replication by potentially facilitating the removal of RNA primers from Okazaki fragments on the lagging strand. Additionally, it is involv... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47063"
] | [
"RNase_H2_subunit_C"
] | [
704
] | 1 | [] | [] | [] | 0 | [
"3kio",
"3p56",
"3p5j",
"3puf",
"8yjz"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
704
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4,
5
] | 4 | true | Family | Ribonuclease H2 subunit C | Ribonuclease H2 subunit C | RNase_H2_subunit_C | 3 |
IPR052864 | 52,864 | Chloroplast Fatty Acid Desaturase CarF | Chloroplast_FAD_CarF | Family | 857 | true | false | The CarF family of fatty acid desaturases is involved in the biosynthesis of chloroplast-specific phosphatidylglycerol molecular species. Members of the CarF family catalyze the introduction of a trans double bond close to the carboxyl group of palmitic acid. This specific enzymatic activity is crucial for the formatio... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48140"
] | [
"Chloroplast_FAD_CarF"
] | [
857
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"Eukaryota",
"viral metagenome"
] | [
2,
854,
1
] | 3 | [
"Arabidopsis thaliana"
] | [
12
] | 1 | true | Family | Chloroplast Fatty Acid Desaturase CarF | Chloroplast Fatty Acid Desaturase CarF | Chloroplast_FAD_CarF | 6 |
IPR052865 | 52,865 | Zinc finger BED domain-containing protein | Zinc_finger_BED | Family | 971 | true | false | This family of proteins includes transcriptional repressors that interact with a specific DNA consensus sequence to regulate gene expression, potentially in a tissue-specific manner. Members of this family are involved in the negative regulation of postnatal growth, particularly affecting muscle and organ development i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47241"
] | [
"Zinc_finger_BED"
] | [
971
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pandoravirus neocaledonia"
] | [
970,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
1
] | 3 | true | Family | Zinc finger BED domain-containing protein | Zinc finger BED domain-containing protein | Zinc_finger_BED | 2 |
IPR052866 | 52,866 | F-box only protein 24 | F-box_protein_24 | Family | 516 | true | false | The F-box only protein 24 family comprises proteins that serve as substrate-recognition components within the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Members of this family are involved in targeting specific protein substrates for ubiquitination, marking them for proteasomal degradation. This regulat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47004"
] | [
"F-box_protein_24"
] | [
516
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
516
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3
] | 3 | true | Family | F-box only protein 24 | F-box only protein 24 | F-box_protein_24 | 5 |
IPR052868 | 52,868 | Izumo sperm-egg fusion | Izumo_fusion | Family | 456 | true | false | This family of proteins is involved in the process of sperm-egg fusion, a critical event in fertilization. Members of this family are characterized by their role in mediating the recognition and binding between sperm and oocyte membranes, facilitating the fusion of these two distinct gametes. The proteins are typically... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37357"
] | [
"Izumo_fusion"
] | [
456
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300645",
"R-MMU-1300645"
] | [
"REACTOME:R-HSA-1300645",
"REACTOME:R-MMU-1300645"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
456
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
5
] | 3 | true | Family | Izumo sperm-egg fusion | Izumo sperm-egg fusion | Izumo_fusion | 4 |
IPR052869 | 52,869 | C-type lectin domain-containing protein 5A | CLEC5A | Family | 447 | true | false | This family of proteins includes cell surface receptors that play a crucial role in osteoclastogenesis and inflammatory responses. They are known to signal through the phosphorylation of TYROBP. In humans, these proteins also serve as macrophage receptors for dengue virus serotypes 1-4, triggering pro-inflammatory cyto... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47536"
] | [
"CLEC5A"
] | [
447
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2172127",
"R-HSA-6798695",
"R-MMU-2172127",
"R-MMU-6798695",
"R-SSC-2172127",
"R-SSC-6798695"
] | [
"REACTOME:R-HSA-2172127",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-2172127",
"REACTOME:R-MMU-6798695",
"REACTOME:R-SSC-2172127",
"REACTOME:R-SSC-6798695"
] | 6 | [
"2yhf"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
447
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
2,
4
] | 4 | true | Family | C-type lectin domain-containing protein 5A | C-type lectin domain-containing protein 5A | CLEC5A | 2 |
IPR052871 | 52,871 | V-set and immunoglobulin domain-containing protein | V-set/Ig_domain | Family | 409 | true | false | This family of proteins includes members that are characterized by the presence of V-set and immunoglobulin domains, which are typically involved in cell adhesion, recognition, and signaling processes. These domains are commonly found in proteins that participate in immune responses, although their exact functions can ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45166"
] | [
"V-set/Ig_domain"
] | [
409
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
409
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Family | V-set and immunoglobulin domain-containing protein | V-set and immunoglobulin domain-containing protein | V-set/Ig_domain | 7 |
IPR052872 | 52,872 | Environmental Stress Response Regulator | ESR_Regulator | Family | 362 | true | false | This family of proteins includes members that are implicated in plant responses to environmental stresses such as cold and drought conditions. They are thought to play roles in the plant's resistance mechanisms by possibly participating in cellular processes that mitigate the effects of these stresses. Some family memb... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37372"
] | [
"ESR_Regulator"
] | [
362
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Thalassoglobus neptunius"
] | [
361,
1
] | 2 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
8
] | 2 | true | Family | Environmental Stress Response Regulator | Environmental Stress Response Regulator | ESR_Regulator | 1 |
IPR052873 | 52,873 | HEAT repeat-containing protein 9 | HEATR9 | Family | 396 | true | false | This family of proteins is characterized by the presence of HEAT repeats, which are tandemly repeated units of approximately 37 to 47 amino acids that are found in a number of cytoplasmic proteins. These repeats are thought to be involved in intracellular transport processes and are implicated in the regulation of a va... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38323"
] | [
"HEATR9"
] | [
396
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nostoc punctiforme (strain ATCC 29133 / PCC 73102)"
] | [
395,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
1
] | 3 | true | Family | HEAT repeat-containing protein 9 | HEAT repeat-containing protein 9 | HEATR9 | 1 |
IPR052877 | 52,877 | Lamin Tail Domain-Containing Protein | Lamin_tail_domain | Family | 329 | true | false | This family of proteins includes members that are involved in the structural organization of the nuclear lamina, which is a dense fibrillar network inside the nucleus of eukaryotic cells. These proteins play a crucial role in maintaining the integrity of nuclear structures and providing mechanical support to the nucleu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19956"
] | [
"Lamin_tail_domain"
] | [
329
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
329
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
3
] | 3 | true | Family | Lamin Tail Domain-Containing Protein | Lamin Tail Domain-Containing Protein | Lamin_tail_domain | 2 |
IPR052878 | 52,878 | Keratin-associated matrix protein | KRTAP_matrix | Family | 294 | true | false | This family of proteins is involved in the structural integrity of hair. They are part of the interfilamentous matrix in the hair cortex, where they interact with hair keratin intermediate filaments. These proteins are crucial for hair shaft formation, providing rigidity and resistance by forming extensive disulfide bo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39653"
] | [
"KRTAP_matrix"
] | [
294
] | 1 | [
"REACTOME"
] | [
"R-HSA-6805567"
] | [
"REACTOME:R-HSA-6805567"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Theria"
] | [
294
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
2
] | 3 | true | Family | Keratin-associated matrix protein | Keratin-associated matrix protein | KRTAP_matrix | 2 |
IPR052879 | 52,879 | Dictyostelium Spore Germination and Stalk Formation | Dd_Spore_Germination_Stalk | Family | 278 | true | false | This family of proteins includes members that are specific to the spore germination and stalk formation stages in the life cycle of the slime mold Dictyostelium discoideum. One member is characterized by an internal repeat motif that is indicative of its role in spore germination. Other members are associated with the ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33239"
] | [
"Dd_Spore_Germination_Stalk"
] | [
278
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
273
] | 2 | [] | [] | 0 | true | Family | Dictyostelium Spore Germination and Stalk Formation | Dictyostelium Spore Germination and Stalk Formation | Dd_Spore_Germination_Stalk | 9 |
IPR052880 | 52,880 | Nematode Receptor-Like Serpentine Class Gamma | NRL-Serpentine_Class_Gamma | Family | 227 | true | false | This family of proteins includes receptors that are part of a larger group known as the serpentine receptor class gamma. These receptors are characterized by their serpentine structure, which typically involves multiple transmembrane domains that allow them to function as signal transducers. They are involved in variou... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31114"
] | [
"NRL-Serpentine_Class_Gamma"
] | [
227
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rhabditidae"
] | [
227
] | 1 | [
"Caenorhabditis elegans"
] | [
20
] | 1 | true | Family | Nematode Receptor-Like Serpentine Class Gamma | Nematode Receptor-Like Serpentine Class Gamma | NRL-Serpentine_Class_Gamma | 5 |
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