LiteFold/InterPro · Datasets at Hugging Face

IPR057586

57,586

NUP210, Ig-like domain 16

Ig_NUP210_16th

Domain

2,245

false

This domain is found in human Nuclear pore membrane glycoprotein 210 (NUP210) and similar animal proteins. NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobulin-like (Ig-like) domains and forms a ring around...

[]

0

[ "PFAM" ]

[ "PF25354" ]

[ "Ig_NUP210_16th" ]

[ 2245 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

69

[ "7r5j", "7r5k" ]

2

[ "PUB00154131" ]

[ "35679397" ]

[ "AI-based structure prediction empowers integrative structural analysis of human nuclear pores." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 47, 2197, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 5, 7 ]

5

true

Domain

NUP210, Ig-like domain 16

Ig_NUP210_16th

6

IPR057587

57,587

Tip attachment protein J, second Ig-like domain

GpJ_Ig_second

Domain

2,838

false

This is the second Ig-like domain found in Tip attachment protein J from Escherichia phage lambda (GpJ) and similar sequences from tailed bacteriophages and bacterial prophages. The Tip attachment protein J (GpJ) from Escherichia phage lambda is a crucial tail fibre protein responsible for recognising and binding the h...

[]

0

[ "PFAM" ]

[ "PF24489" ]

[ "Ig_J_second" ]

[ 2838 ]

1

[]

0

[ "8iyk", "8iyl", "8k35", "8xcg", "8xci", "8xcj", "8xck", "9e7m" ]

8

[ "PUB00075602", "PUB00075672", "PUB00155633", "PUB00155963" ]

[ "6228546", "23542343", "38096144", "38760367" ]

[ "Proteinase sensitivity of bacteriophage lambda tail proteins gpJ and pH in complexes with the lambda receptor.", "Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster.", "Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor bi...

[ 1984, 2013, 2023, 2024 ]

4

[]

0

null

[ "Bacteria", "Ecdysozoa", "Viruses", "human gut metagenome" ]

[ 2729, 2, 105, 2 ]

4

[]

0

true

Domain

Tip attachment protein J, second Ig-like domain

GpJ_Ig_second

8

IPR057588

57,588

NWD1/2-like, winged helix-turn-helix domain

NWD1/2-like_WH

Domain

4,471

false

This domain is found in human NACHT domain- and WD repeat-containing protein 1/2 (NWD1/2), the orthologue Protein qui-1 from Caenorhabditis elegans and similar animal proteins. This domain is predicted to adopt a winged helix-turn-helix fold. NWD1 may play a role in the control of androgen receptor protein steady-state...

[]

0

[ "PFAM" ]

[ "PF25469" ]

[ "WHD_NWD1" ]

[ 4471 ]

1

[]

0

[]

0

[ "PUB00093872", "PUB00160540", "PUB00160541" ]

[ "24681825", "14988722", "26976437" ]

[ "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.", "Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans.", "A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in C...

[ 2014, 2004, 2016 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 11, 4458, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 9, 6, 3, 5, 9 ]

6

true

Domain

NWD1/2-like, winged helix-turn-helix domain

NWD1/2-like_WH

8

IPR057589

57,589

PLOD1-3-like, GT domain

GT_PLOD

Domain

5,577

false

This entry represents the N-terminal glycosyltransferase (GT) domain found in collagen lysyl hydroxylases (LH or PLOD), mainly found in animals, including human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1/2 and Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD1-3). The two N-termin...

[]

0

[ "PFAM" ]

[ "PF25342" ]

[ "GT_PLOD" ]

[ 5577 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11.4", "PWY-7894", "R-CEL-1650814", "R-DME-1650814", "R-HSA-1650814", "R-MMU-1650814", "R-RNO-1650814" ]

[ "EC:1.14.11.4", "METACYC:PWY-7894", "REACTOME:R-CEL-1650814", "REACTOME:R-DME-1650814", "REACTOME:R-HSA-1650814", "REACTOME:R-MMU-1650814", "REACTOME:R-RNO-1650814" ]

7

[ "6fxk", "6fxm", "6fxr", "6fxt", "6fxx", "6fxy", "6te3", "6tec", "6tes", "6teu", "6tex", "6tez", "6wfv", "8one", "8zgc", "8zge", "8zgg", "8zgh", "9dyt", "9dzs", "9e92" ]

21

[ "PUB00091106", "PUB00160136", "PUB00160137", "PUB00160138" ]

[ "30089812", "37446392", "29178448", "21699693" ]

[ "Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3.", "Identification of Regulatory Molecular \"Hot Spots\" for LH/PLOD Collagen Glycosyltransferase Activity.", "Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2.", "Phenotyp...

[ 2018, 2023, 2018, 2011 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 82, 5397, 34, 64 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 1, 24, 9, 13 ]

6

true

Domain

PLOD1-3-like, GT domain

GT_PLOD

5

IPR057590

57,590

RDR1/2-like, PH-like domain

PH_RDR1/2-like

Domain

2,007

false

This domain is found in RNA-dependent RNA polymerase 1/2 (RDR1/2) from Arabidopsis thaliana and related plant proteins. It adopts a β-barrel structure with significant similarity to known PH domains [ ]. RDR1/2 are involved in the production of small interfering RNAs (siRNAs). RDR1 is involved in antiviral silencing, a...

[]

0

[ "PFAM" ]

[ "PF24823" ]

[ "PH_RDR2" ]

[ 2007 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "7eu0", "7eu1", "7roz", "7rqs", "7w82", "7w84", "7w88", "8xmb", "8xmc", "8xmd", "8xme" ]

11

[ "PUB00148894", "PUB00148896", "PUB00155792", "PUB00155793" ]

[ "19308254", "19966292", "34903670", "23142082" ]

[ "Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis.", "RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana.", "Structure and RNA template requirements of <i>Arabidopsis</i> RNA-DEPENDENT RNA POL...

[ 2009, 2010, 2021, 2012 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2007 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 3, 15 ]

3

true

Domain

RDR1/2-like, PH-like domain

PH_RDR1/2-like

7

IPR057591

57,591

TMEM126-like

Family

167

false

This entry represents a family of proteins from nematodes that have sequence and structural similarity to the TMEM126 family of integral membrane proteins that are involved in the assembly of complex I. Therefore these proteins may have a similar function. However, it has also been suggested that this assembly function...

[]

0

[ "PFAM" ]

[ "PF23408" ]

[ "TMEM126_like" ]

[ 167 ]

1

[]

0

[]

0

[ "PUB00155866" ]

[ "27048931" ]

[ "The origin of the supernumerary subunits and assembly factors of complex I: A treasure trove of pathway evolution." ]

[ 2016 ]

1

[]

0

null

[ "Protostomia" ]

[ 167 ]

1

[ "Caenorhabditis elegans" ]

[ 3 ]

1

true

Family

TMEM126-like

8

IPR057592

57,592

TMEM131 homolog, sixth Ig-like domain

Ig_TMEM131H_6

Domain

47

false

This entry represents the sixth Ig-like domain of TMEM131 from Drosophila and related sequences from flies. This protein is the orthologue of human TMEM131. TMEM131 is a collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII [ ]. Human TMEM131 is p...

[]

0

[ "PFAM" ]

[ "PF24505" ]

[ "Ig_TMEM131homol_6th" ]

[ 47 ]

1

[]

0

[]

0

[ "PUB00155677" ]

[ "32095531" ]

[ "Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking." ]

[ 2020 ]

1

[]

0

null

[ "Schizophora" ]

[ 47 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Domain

TMEM131 homolog, sixth Ig-like domain

Ig_TMEM131H_6

5

IPR057593

57,593

TMEM131 homolog, third Ig-like domain

TMEM131H_Ig_3

Domain

40

false

This entry represents the third Ig-like domain of TMEM131 from Drosophila and related sequences from flies. This protein is the orthologue of human TMEM131. TMEM131 is a collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII [ ]. Human TMEM131 is p...

[]

0

[ "PFAM" ]

[ "PF24502" ]

[ "Ig_TMEM131homol_3rd" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00155677" ]

[ "32095531" ]

[ "Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking." ]

[ 2020 ]

1

[]

0

null

[ "Brachycera" ]

[ 40 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Domain

TMEM131 homolog, third Ig-like domain

TMEM131H_Ig_3

3

IPR057594

57,594

TgrO1-like, immunoglobulin-like domain

TgrO1-like_Ig

Domain

118

false

This immunoglobulin-like domain (Ig-like) is found twice in Tiger protein O1 from Dictyostelium discoideum (TgrO1) and similar sequences from lower eukaryotes. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF24612" ]

[ "Ig_TgrO1" ]

[ 118 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dictyosteliaceae" ]

[ 118 ]

1

[]

0

true

Domain

TgrO1-like, immunoglobulin-like domain

TgrO1-like_Ig

3

IPR057595

57,595

TopBP1/SLF1, BRCT domain

TopB1_SLF1_BRCT

Domain

1,828

false

This entry represents a BRCT domain found in TopBP1 and SLF1. It corresponds to the eight BRCT domain of TopBP1 and the second one in SLF1. TopBP1, also known as DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response, acting as a scaffold...

[]

0

[ "PFAM" ]

[ "PF23294" ]

[ "BRCT_TopB1_SLF1" ]

[ 1828 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5685938", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-9709570", "R-MMU-5685938", "R-MMU-5693607", "R-MMU-6804756", "R-MMU-69473" ]

[ "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-9709570", "REACTOME:R-MMU-5685938", "REACTOME:R-MMU-5693607", "REACTOME:R-MMU-6804756", "REACTOME:R-MMU-69473" ]

10

[ "3al2", "3al3", "7cmz", "8ir2", "8ir4" ]

5

[ "PUB00057784", "PUB00062121", "PUB00062122", "PUB00062123", "PUB00062124", "PUB00062125", "PUB00062126", "PUB00062241", "PUB00069981", "PUB00076895", "PUB00139686", "PUB00139687", "PUB00139688", "PUB00153350", "PUB00153351", "PUB00153352" ]

[ "19937654", "10498869", "11395493", "11714696", "12697828", "15075294", "16530042", "21659603", "20811708", "25931565", "12773567", "15138768", "9461304", "33592542", "35597237", "37674080" ]

[ "Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1.", "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.", "BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.", "Co...

[ 2010, 1999, 2001, 2002, 2003, 2004, 2006, 2011, 2010, 2015, 2003, 2004, 1997, 2021, 2022, 2023 ]

16

[]

0

null

[ "Eukaryota" ]

[ 1828 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 5, 7 ]

4

true

Domain

TopBP1/SLF1, BRCT domain

TopB1_SLF1_BRCT

5

IPR057596

57,596

RDRP, core domain

RDRP_core

Domain

13,672

false

This domain is found mainly in eukaryotic RDRP. It is composed of multiple domains representing the polymerase core. RNA dependent RNA polymerases (RDRP) enzymes (RDRP; ) are involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing [ ]; they are also required for transcriptional ...

[]

0

[ "PFAM" ]

[ "PF05183" ]

[ "RdRP" ]

[ 13672 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "2j7n", "2j7o", "5fsw", "7eu0", "7eu1", "7roz", "7rqs", "7w82", "7w84", "7w88", "7y7p", "7y7q", "7y7r", "7y7s", "7y7t", "8xmb", "8xmc", "8xmd", "8xme" ]

19

[ "PUB00016353", "PUB00020227", "PUB00020228", "PUB00035781", "PUB00092792" ]

[ "12553882", "11719187", "10850496", "16691418", "20957187" ]

[ "Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases.", "On the role of RNA amplification in dsRNA-triggered gene silencing.", "An RNA-dependent RNA polymerase gene in Arabidopsis is required for p...

[ 2003, 2001, 2000, 2006, 2010 ]

5

[]

0

null

[ "Bacillati", "Eukaryota", "Viruses", "bioreactor metagenome" ]

[ 146, 13506, 19, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 41, 5, 3, 15, 1, 50 ]

6

true

Domain

RDRP, core domain

RDRP_core

2

IPR057597

57,597

Receptor-like PK ALE2, N-terminal domain

ALE2_N

Domain

3,812

false

This entry represents the N-terminal in Receptor-like serine/threonine-protein kinase ALE2 and related proteins found mainly in plants. ALE2 is required during the differentiation of the protoderm into shoots, epidermis and cuticle [ ]. This domain is predicted to adopt a globular α/β structure that has some structural...

[]

0

[ "PFAM" ]

[ "PF23180" ]

[ "ALE2_N" ]

[ 3812 ]

1

[]

0

[]

0

[ "PUB00005115", "PUB00015362", "PUB00020114", "PUB00034898", "PUB00034899", "PUB00155490" ]

[ "3291115", "12368087", "12471243", "15078142", "15320712", "17376810" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Evolution of protein kinase signaling from yeast to man.", "The protein kinase complement of the human genome.", "High-throughput structural biology in drug discovery: protein kinases.", "Creating chemical dive...

[ 1988, 2002, 2002, 2004, 2004, 2007 ]

6

[]

0

null

[ "Viridiplantae" ]

[ 3812 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 18, 58 ]

3

true

Domain

Receptor-like PK ALE2, N-terminal domain

ALE2_N

9

IPR057598

57,598

Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain

Fn3_PTPRU

Domain

11,697

false

This entry represents the fourth divergent fibronectin type 3 domain found in a group of Receptor-type tyrosine-protein phosphatases (PTPR) including PTPR U, kappa, mu, T and related proteins. This domain is closest to the transmembrane α-helix. PTPRU, also known as pancreatic carcinoma phosphatase 2 (PCP-2), belongs t...

[]

0

[ "PFAM" ]

[ "PF23144" ]

[ "Fn3_PTPRU" ]

[ 11697 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.48", "R-DME-114604", "R-DME-354192", "R-DME-5621480", "R-DME-9013407", "R-DME-912631", "R-DME-9674555", "R-DME-9705462", "R-DRE-1433557", "R-HSA-1433557", "R-HSA-182971", "R-MMU-1433557", "R-MMU-182971" ]

[ "EC:3.1.3.48", "REACTOME:R-DME-114604", "REACTOME:R-DME-354192", "REACTOME:R-DME-5621480", "REACTOME:R-DME-9013407", "REACTOME:R-DME-912631", "REACTOME:R-DME-9674555", "REACTOME:R-DME-9705462", "REACTOME:R-DRE-1433557", "REACTOME:R-HSA-1433557", "REACTOME:R-HSA-182971", "REACTOME:R-MMU-1433557...

13

[ "2v5y", "8a16", "8a17" ]

3

[ "PUB00035793", "PUB00035794", "PUB00035795", "PUB00035796", "PUB00035797", "PUB00035798", "PUB00063532", "PUB00139468", "PUB00139470" ]

[ "9818190", "14625689", "12678841", "16672235", "8948575", "9646865", "10397721", "16574648", "12501215" ]

[ "Protein tyrosine phosphatases: mechanisms of catalysis and regulation.", "Receptor and nonreceptor protein tyrosine phosphatases in the nervous system.", "An overview of the protein tyrosine phosphatase superfamily.", "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase dom...

[ 1998, 2003, 2003, 2006, 1996, 1998, 1999, 2006, 2002 ]

9

[]

0

null

[ "Eumetazoa" ]

[ 11697 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 161, 2, 23, 18, 27 ]

5

true

Domain

Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain

Fn3_PTPRU

6

IPR057599

57,599

TORTIFOLIA1/TORL1-2, C-terminal

TORTIFOLIA1/TORL1-2_C

Domain

1,607

false

This entry represents a domain found at the C-terminal of TORTIFOLIA1/SPIRAL2, TORTIFOLIA1-like protein 1/2 from Arabidopsis thaliana and related proteins. This domain may consist of TPRs. TORTIFOLIA1/SPIRAL2 and SPIRAL2-like (SP2L) from Arabidopsis regulate the orientation of cortical microtubules and the direction of...

[]

0

[ "PFAM" ]

[ "PF24713" ]

[ "TOR1L1_C" ]

[ 1607 ]

1

[]

0

[ "8f8n", "8hbr" ]

2

[ "PUB00078491", "PUB00078492", "PUB00078498" ]

[ "18577573", "24055158", "25133612" ]

[ "Arabidopsis SPIRAL2 promotes uninterrupted microtubule growth by suppressing the pause state of microtubule dynamics.", "SPIRAL2 determines plant microtubule organization by modulating microtubule severing.", "Experimental virus evolution reveals a role of plant microtubule dynamics and TORTIFOLIA1/SPIRAL2 in ...

[ 2008, 2013, 2014 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1607 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 5, 30 ]

3

true

Domain

TORTIFOLIA1/TORL1-2, C-terminal

TORTIFOLIA1/TORL1-2_C

5

IPR057600

57,600

TORTIFOLIA1/SINE1-2, N-terminal

TORTIFOLIA1/SINE1-2_N

Domain

4,478

false

This entry represents a domain found at the N-terminal of TORTIFOLIA1/SPIRAL2, SPIRAL2-like (SP2L) and related sequences such as SINE1/2, which function during stomatal dynamics induced by light-dark transitions and abscisic acid (ABA), that requires F-actin reorganisation [ ]. TORTIFOLIA1/SPIRAL2 and SPIRAL2-like (SP2...

[]

0

[ "PFAM" ]

[ "PF24714" ]

[ "TOR1L1_N" ]

[ 4478 ]

1

[]

0

[ "8d00", "8y9r" ]

2

[ "PUB00078491", "PUB00078492", "PUB00078498", "PUB00155149" ]

[ "18577573", "24055158", "25133612", "37819623" ]

[ "Arabidopsis SPIRAL2 promotes uninterrupted microtubule growth by suppressing the pause state of microtubule dynamics.", "SPIRAL2 determines plant microtubule organization by modulating microtubule severing.", "Experimental virus evolution reveals a role of plant microtubule dynamics and TORTIFOLIA1/SPIRAL2 in ...

[ 2008, 2013, 2014, 2024 ]

4

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 4472, 6 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 34, 16, 78 ]

3

true

Domain

TORTIFOLIA1/SINE1-2, N-terminal

TORTIFOLIA1/SINE1-2_N

5

IPR057601

57,601

TonB-dependent transporter Oar-like, beta-barrel domain

Oar-like_b-barrel

Domain

11,160

false

This entry represents the β-barrel domain of TonB-dependent transporter Oar from Myxococcus xanthus and similar bacterial outer membrane β-barrel proteins. Many of these proteins contain an N-terminal domain. TonB proteins are bacterial membrane proteins that play a crucial role in energy-dependent active transport sys...

[]

0

[ "PFAM" ]

[ "PF25183" ]

[ "OMP_b-brl_4" ]

[ 11160 ]

1

[]

0

[]

0

[ "PUB00006673", "PUB00014980", "PUB00014981", "PUB00014986", "PUB00035726", "PUB00089681" ]

[ "9886293", "14499604", "9865695", "11872840", "15993072", "17056600" ]

[ "Crystal structure of the outer membrane active transporter FepA from Escherichia coli.", "The Escherichia coli outer membrane cobalamin transporter BtuB: structural analysis of calcium and substrate binding, and identification of orthologous transporters by sequence/structure conservation.", "Transmembrane sig...

[ 1999, 2003, 1998, 2002, 2005, 2007 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10988, 19, 153 ]

3

[]

0

true

Domain

TonB-dependent transporter Oar-like, beta-barrel domain

Oar-like_b-barrel

9

IPR057602

57,602

PARP12-like, CCCH zinc finger tandem

Zfn-CCCH_PARP12

Domain

2,439

false

This domain containing tandem CCCH zinc fingers is found in human Protein mono-ADP-ribosyltransferase PARP12, and related proteins mainly found in vertebrates, including Zinc finger CCCH-type antiviral protein 1 (ZAP) and Zinc finger CCCH-type antiviral protein 1-like. PARP12 is a mono-ADP-ribosyltransferase that media...

[]

0

[ "PFAM" ]

[ "PF25261" ]

[ "zf-CCCH_PARP12" ]

[ 2439 ]

1

[ "REACTOME" ]

[ "R-HSA-6802952" ]

[ "REACTOME:R-HSA-6802952" ]

1

[ "3u9g", "6l1w", "6uei", "6uej", "9bgl" ]

5

[ "PUB00146699", "PUB00160212" ]

[ "25043379", "18225958" ]

[ "Family-wide analysis of poly(ADP-ribose) polymerase activity.", "Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein." ]

[ 2014, 2008 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 2439 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 8, 5, 10 ]

4

true

Domain

PARP12-like, CCCH zinc finger tandem

Zfn-CCCH_PARP12

2

IPR057603

57,603

Periphilin-1, C-terminal domain

Periphilin-1_C

Domain

2,417

false

This domain is found in human Periphilin-1 and related proteins. It folds into an α-helical hairpin and directs HUSH complex assembly by dimerising and binding a TASOR, another component of the HUSH complex [ ]. Periphilin-1 is a component of the HUSH complex, a multiprotein complex that mediates epigenetic repression....

[]

0

[ "PFAM", "CDD" ]

[ "PF25234", "cd22896" ]

[ "Periphilin_C", "periphilin-like" ]

[ 2417, 2092 ]

2

[ "REACTOME" ]

[ "R-HSA-9843970" ]

[ "REACTOME:R-HSA-9843970" ]

1

[ "6swg" ]

1

[ "PUB00053510", "PUB00069477", "PUB00069478", "PUB00069707", "PUB00087337", "PUB00109326", "PUB00109327", "PUB00109328", "PUB00109329", "PUB00109330", "PUB00109331", "PUB00109332", "PUB00109333" ]

[ "18374642", "12853457", "12087473", "17963697", "26022416", "32976585", "19730898", "32854034", "15474462", "29891865", "26070530", "25608663", "12366696" ]

[ "Histone ubiquitination: triggering gene activity.", "Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.", "Serological identification and expression analysis of gastric cancer-associated genes.", "CR/periphilin is a...

[ 2008, 2003, 2002, 2007, 2015, 2020, 2010, 2020, 2004, 2018, 2015, 2015, 2002 ]

13

[]

0

null

[ "Eumetazoa" ]

[ 2417 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 12, 8, 8, 11 ]

5

true

Domain

Periphilin-1, C-terminal domain

Periphilin-1_C

6

IPR057606

57,606

Ras/Rap GTPase-activating protein SynGAP-like, PH domain

SynGAP1-like_PH

Domain

8,865

false

This entry represents a pleckstrin homology (PH) domain found in animal RAS GTPase-activating proteins, including mouse RAS/RAP GTPase-activating protein SynGAP, RAS protein activator-like 3 (Rasal3), and disabled homolog 2-interacting protein (DAB2IP). This domain likely plays a role in membrane targeting and regulati...

[]

0

[ "PFAM" ]

[ "PF25321" ]

[ "PH_RASGAP" ]

[ 8865 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5658442", "R-HSA-5658442", "R-HSA-9696264", "R-HSA-9696273", "R-MMU-5658442", "R-RNO-5658442" ]

[ "REACTOME:R-DME-5658442", "REACTOME:R-HSA-5658442", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-5658442", "REACTOME:R-RNO-5658442" ]

6

[]

0

[ "PUB00072686", "PUB00072689", "PUB00100694", "PUB00100696", "PUB00160542", "PUB00160543", "PUB00160544" ]

[ "19903888", "23056358", "16537406", "15500970", "15312654", "22696229", "25652366" ]

[ "DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.", "Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex.", "SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons.", "Impaired SynGAP expression and long...

[ 2009, 2012, 2006, 2004, 2004, 2012, 2015 ]

7

[]

0

null

[ "Eukaryota" ]

[ 8865 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 96, 9, 21, 29, 37 ]

6

true

Domain

Ras/Rap GTPase-activating protein SynGAP-like, PH domain

SynGAP1-like_PH

6

IPR057607

57,607

PH-like domain, kinetoplastids

PH_kinetoplastids

Domain

66

false

This entry represents PH-like domains found in a group of uncharacterised proteins from unicellular eukaryotes, primarily kinetoplastids. The domain is found in several different domain architectures with Pex24p-like domains , or phosphatases.

[]

0

[ "PFAM" ]

[ "PF25404" ]

[ "PH_29" ]

[ 66 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 66 ]

1

[]

0

true

Domain

PH-like domain, kinetoplastids

PH_kinetoplastids

6

IPR057608

57,608

PH-like domain 2, kinetoplastids

PH_2_kinetoplastids

Domain

116

false

This entry represents a domain found at the C-terminal of a group of uncharacterised kinetoplastid proteins. This domain adopts a PH-like domain fold.

[]

0

[ "PFAM" ]

[ "PF25406" ]

[ "PH_31" ]

[ 116 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 116 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 1 ]

1

true

Domain

PH-like domain 2, kinetoplastids

PH_2_kinetoplastids

4

IPR057609

57,609

PH-like domain, platyhelminthes

PH_platyhelminthes

Domain

29

false

This entry represents a PH-like domain found in uncharacterised platyhelminthes proteins that often have an N-terminal RasGAP domain ( ).

[]

0

[ "PFAM" ]

[ "PF25410" ]

[ "PH_34" ]

[ 29 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Digenea" ]

[ 29 ]

1

[]

0

true

Domain

PH-like domain, platyhelminthes

PH_platyhelminthes

9

IPR057610

57,610

Phage antiviral trigger protein Gp54-like

Gp54-like

Family

93

false

This entry represents a small phage family of proteins of approximately 66 amino acids that act as a trigger for bacterial antiviral defence systems [ ]. The protein adopts a rare six-stranded β-barrel fold in its unbound state. Upon binding to the bacterial CapRel defence protein, Gp54 undergoes a dramatic conformatio...

[]

0

[ "PFAM" ]

[ "PF25180" ]

[ "Gp54" ]

[ 93 ]

1

[]

0

[ "9axb", "9erv" ]

2

[ "PUB00160133" ]

[ "39415022" ]

[ "A bacterial immunity protein directly senses two disparate phage proteins." ]

[ 2024 ]

1

[]

0

null

[ "Salmonella dublin", "Viruses" ]

[ 1, 92 ]

2

[]

0

true

Family

Phage antiviral trigger protein Gp54-like

Gp54-like

7

IPR057611

57,611

Piezo-type, mechanosensitive ion channel homolog domain

PIEZO_dom

Domain

992

false

This domain is found in Piezo-type mechanosensitive ion channel homolog from Arabidopsis thaliana (PIEZO) and related plant proteins. PIEZO is a pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and potassium ions. This domain is predicted to adopt an all-α structure.This...

[]

0

[ "PFAM" ]

[ "PF25288" ]

[ "PIEZO" ]

[ 992 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 992 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 13 ]

3

true

Domain

Piezo-type, mechanosensitive ion channel homolog domain

PIEZO_dom

6

IPR057612

57,612

PIFI-like, Ig-like domain

Ig_PIFI

Domain

638

false

PIFI is required during nonphotochemical quenching and is involved in NAD(P)H dehydrogenase complex-mediated chlororespiratory electron transport [ ]. This predicted immunoglobulin-like (Ig-like) domain is found in Protein POST-ILLUMINATION CHLOROPHYLL FLUORESCENCE INCREASE, chloroplastic from Arabidopsis thaliana (PIF...

[]

0

[ "PFAM" ]

[ "PF25419" ]

[ "Ig_PIFI" ]

[ 638 ]

1

[]

0

[]

0

[ "PUB00097966" ]

[ "17573537" ]

[ "A novel nucleus-encoded chloroplast protein, PIFI, is involved in NAD(P)H dehydrogenase complex-mediated chlororespiratory electron transport in Arabidopsis." ]

[ 2007 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 638 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 4, 7 ]

3

true

Domain

PIFI-like, Ig-like domain

Ig_PIFI

9

IPR057613

57,613

VWA7, beta-sandwich domain

VWA7_4

Domain

686

false

This domain is found in the human VWA7 and related proteins. The domain is predicted to fold into a β-sandwich. VWA7 is found in the major histocompatibility complex class III region and it is likely implicated in lung cancers [ ] The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutan...

[]

0

[ "PFAM" ]

[ "PF23610" ]

[ "VWA7_4" ]

[ 686 ]

1

[]

0

[]

0

[ "PUB00001522", "PUB00001619", "PUB00003322", "PUB00003554", "PUB00160748" ]

[ "8440408", "1864378", "8145250", "8412987", "11261934" ]

[ "von Willebrand factor.", "Shuffled domains in extracellular proteins.", "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by aver...

[ 1993, 1991, 1994, 1993, 2001 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 686 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 8, 3, 2 ]

4

true

Domain

VWA7, beta-sandwich domain

VWA7_4

2

IPR057614

57,614

Serine/threonine-protein kinase PKH3, C-terminal PH domain

PH_PKH3_C

Domain

144

false

This entry represents a pleckstrin homology (PH) domain found at the C-terminal of PKH3 protein kinases. The domain is found C-terminal to a protein kinase catalytic domain (Pkinase, ). PKH3 kinases are involved in serine/threonine phosphorylation. Eukaryotic protein kinases [ , , , , ] are enzymes that belong to a ver...

[]

0

[ "PFAM" ]

[ "PF25347" ]

[ "PH_PKH3_C" ]

[ 144 ]

1

[]

0

[]

0

[ "PUB00001530", "PUB00003568", "PUB00003569", "PUB00005115", "PUB00005145", "PUB00015293" ]

[ "7768349", "1835513", "1956325", "3291115", "1862342", "12734000" ]

[ "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.", "Protein kinase classification.", "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.", "The ...

[ 1995, 1991, 1991, 1988, 1991, 2003 ]

6

[]

0

null

[ "Saccharomycotina" ]

[ 144 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Serine/threonine-protein kinase PKH3, C-terminal PH domain

PH_PKH3_C

5

IPR057615

57,615

VWA7, Ig-like domain

Ig_VWA7

Domain

1,485

false

This domain id found in the human von Willebrand factor A domain-containing protein 7 (VWA7) and related proteins. It is predicted to fold into a β-sandwich with an Ig-like topology. VWA7 is found in the major histocompatibility complex class III region and it is likely implicated in lung cancers [ ] The von Willebrand...

[]

0

[ "PFAM" ]

[ "PF23619" ]

[ "Ig_VWA7" ]

[ 1485 ]

1

[]

0

[]

0

[ "PUB00001522", "PUB00001619", "PUB00003322", "PUB00003554", "PUB00160748" ]

[ "8440408", "1864378", "8145250", "8412987", "11261934" ]

[ "von Willebrand factor.", "Shuffled domains in extracellular proteins.", "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by aver...

[ 1993, 1991, 1994, 1993, 2001 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "marine sediment metagenome" ]

[ 7, 50, 1425, 3 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 2, 7, 3, 2 ]

5

true

Domain

VWA7, Ig-like domain

Ig_VWA7

3

IPR057616

57,616

PH-like domain 2, platyhelminthes

PH_2_platyhelminthes

Domain

78

false

This entry represents a PH domain found in a range of platyhelminthes proteins. This domain could be found adjacent to the C-terminal of DH domains .

[]

0

[ "PFAM" ]

[ "PF25407" ]

[ "PH_32" ]

[ 78 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Platyhelminthes" ]

[ 78 ]

1

[]

0

true

Domain

PH-like domain 2, platyhelminthes

PH_2_platyhelminthes

7

IPR057617

57,617

PML, C-terminal domain

PML_C

Domain

1,034

false

This domain is found at the C-terminal in human and mice Protein PML and its orthologues in animals. TRIM19, also known as PML, acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour suppression, transcriptional regulation, apoptosis, senescence, DNA damage...

[]

0

[ "PFAM" ]

[ "PF25244" ]

[ "PML_C" ]

[ 1034 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3108214", "R-HSA-3232142", "R-HSA-6804758", "R-HSA-877300", "R-HSA-8934593", "R-HSA-8948747", "R-HSA-9609690", "R-HSA-9616222", "R-MMU-3108214", "R-MMU-3232142", "R-MMU-6804758", "R-MMU-8934593", "R-MMU-8948747" ]

[ "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-3232142", "REACTOME:R-HSA-6804758", "REACTOME:R-HSA-877300", "REACTOME:R-HSA-8934593", "REACTOME:R-HSA-8948747", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9616222", "REACTOME:R-MMU-3108214", "REACTOME:R-MMU-3232142", "REACTOME:R-MMU-6804758", "REACTOME...

13

[]

0

[ "PUB00102048", "PUB00160545", "PUB00160546", "PUB00160547" ]

[ "28250117", "11500381", "11575918", "18391071" ]

[ "The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus.", "PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.", "The RING domains of the promyelocytic leukemia protein PML and...

[ 2017, 2001, 2001, 2008 ]

4

[]

0

null

[ "Eumetazoa", "Malaco herpesvirus 4" ]

[ 1033, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 5 ]

3

true

Domain

PML, C-terminal domain

PML_C

3

IPR057618

57,618

POGZ/Z280C-D-like, double Zinc finger

Znf_POGZ/Z280C-D-like

Domain

3,440

false

This zinc finger domain is found in several zinc-finger proteins such as Zinc finger protein 280C and 280D as well as protein Pogo transposable element with ZNF domain (POGZ) find in eukaryotes. This domain contains two consecutive zinc fingers that are predicted to adopt structures similar to the classical C2H2 zinc f...

[]

0

[ "PFAM" ]

[ "PF25429" ]

[ "zf-POGZ" ]

[ 3440 ]

1

[]

0

[]

0

[ "PUB00107331", "PUB00160208" ]

[ "20562864", "26721387" ]

[ "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.", "Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination." ]

[ 2010, 2016 ]

2

[]

0

null

[ "Bilateria" ]

[ 3440 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 19, 3, 11, 13, 20 ]

5

true

Domain

POGZ/Z280C-D-like, double Zinc finger

Znf_POGZ/Z280C-D-like

7

IPR057619

57,619

Poor homologous synapsis 1, PH domain

PH_PHS1

Domain

626

false

This entry represents a pleckstrin homology (PH) domain found in Poor Homologous Synapsis from Arabidopsis thaliana (PHS1) and similar plant proteins. PHS1 is required for accurate chromosome segregation in meiosis and for pairing to occur between homologous chromosomes. It acts in early recombination steps and ensures...

[]

0

[ "PFAM" ]

[ "PF25349" ]

[ "PH_PHS1" ]

[ 626 ]

1

[]

0

[]

0

[ "PUB00160548" ]

[ "19918061" ]

[ "PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus." ]

[ 2009 ]

1

[]

0

null

[ "Streptophytina" ]

[ 626 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 3, 12 ]

3

true

Domain

Poor homologous synapsis 1, PH domain

PH_PHS1

1

IPR057621

57,621

Ketohexokinase, prokaryotic

Khk_prokaryotic

Family

362

false

This prokaryotic protein family includes Ketohexokinase from Haloferax volcanii, which catalyses the ATP-dependent phosphorylation of the ketose sugar fructose to fructose-1-phosphate [ ].

[]

0

[ "PFAM" ]

[ "PF25270" ]

[ "Khk" ]

[ 362 ]

1

[]

0

[]

0

[ "PUB00160148" ]

[ "38587824" ]

[ "Identification and characterization of a novel type of ketohexokinase from the haloarchaeon Haloferax volcanii." ]

[ 2024 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 184, 173, 5 ]

3

[]

0

true

Family

Ketohexokinase, prokaryotic

Khk_prokaryotic

7

IPR057623

57,623

PUB 12/19-like, N-terminal domain

PUB12-19-like_N

Domain

5,236

false

This domain is found at the N-terminal end of U-box domain-containing protein 12-19 from Arabidopsis thaliana (PUB12-19) and similar plant E3 ubiquitin ligases. This domain is usually found associated with and and is predicted to show an all-α configuration. The U-box domain-containing proteins function as E3 ubiquitin...

[]

0

[ "PFAM" ]

[ "PF25368" ]

[ "PUB10_N" ]

[ 5236 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00155815" ]

[ "29237060" ]

[ "News from the PUB: plant U-box type E3 ubiquitin ligases." ]

[ 2018 ]

1

[]

0

null

[ "Streptophyta" ]

[ 5236 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 41, 14, 22 ]

3

true

Domain

PUB 12/19-like, N-terminal domain

PUB12-19-like_N

3

IPR057624

57,624

Telomere ends associated, alpha-helical domain

Tea_helical

Domain

107

false

This entry represents a small domain that is present four times in Protein telomere ends associated (Tea) from Drosophila and related fly sequences. This domain may adopt an α-helical fold. Tea protects telomeres from fusion and it likely functions as a component of the MTV complex along with moi and ver. The complex b...

[]

0

[ "PFAM" ]

[ "PF24236" ]

[ "Tea_helical" ]

[ 107 ]

1

[]

0

[]

0

[ "PUB00154269" ]

[ "27835648" ]

[ "MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila." ]

[ 2016 ]

1

[]

0

null

[ "Schizophora" ]

[ 107 ]

1

[ "Drosophila melanogaster" ]

[ 5 ]

1

true

Domain

Telomere ends associated, alpha-helical domain

Tea_helical

1

IPR057625

57,625

Telomere repeat-binding protein 1-6-like, ubiquitin-like domain

TPR1-6-like_ubiquitin

Domain

2,547

false

This domain is found in Telomere repeat-binding protein 1-6 from Arabidopsis thaliana (TPR1-6) and similar plant proteins. This domain is predicted to adopt a ubiquitin-like fold. AtTRP1 binds specifically to the plant telomeric double-stranded DNA sequences 5'-GGTTTAG-3' [ ]. It interacts with the ethylene receptor ER...

[]

0

[ "PFAM" ]

[ "PF23603" ]

[ "Ubiquitin_TPR1" ]

[ 2547 ]

1

[]

0

[]

0

[ "PUB00053133", "PUB00074631", "PUB00074638", "PUB00160552" ]

[ "19567478", "11278537", "17272298", "15688221" ]

[ "AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis.", "A plant gene encoding a Myb-like protein that binds telomeric GGTTTAG repeats in vitro.", "Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeosta...

[ 2009, 2001, 2007, 2005 ]

4

[]

0

null

[ "Streptophytina" ]

[ 2547 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 4, 24 ]

3

true

Domain

Telomere repeat-binding protein 1-6-like, ubiquitin-like domain

TPR1-6-like_ubiquitin

9

IPR057626

57,626

Temptin, Cys/Cys disulfide domain

S-S_Temptin

Domain

1,663

false

This domain is found in Temptin and similar proteins in eukaryotes and bacteria. This domain contains two highly conserved cysteines that are predicted to form a disulphide bond. It is also enriched with conserved acidic residues. Temptin is a component of the complex of water-borne protein pheromones that stimulates a...

[]

0

[ "PFAM" ]

[ "PF24784" ]

[ "Temptin_C" ]

[ 1663 ]

1

[]

0

[]

0

[ "PUB00155344", "PUB00155345" ]

[ "15054104", "17894821" ]

[ "Characterization of Aplysia enticin and temptin, two novel water-borne protein pheromones that act in concert with attractin to stimulate mate attraction.", "Aplysia temptin - the 'glue' in the water-borne attractin pheromone complex." ]

[ 2004, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 19, 1636, 5, 3 ]

4

[]

0

true

Domain

Temptin, Cys/Cys disulfide domain

S-S_Temptin

6

IPR057627

57,627

Teneurin 1-4-like, FN-plug domain

FN-plug_TEN1-4

Domain

9,313

false

This entry represents the FN-plug domain found near the central region of Teneurins 1 to 4. This domain forms numerous hydrogen-bonding and hydrophobic interactions with the YD-shell interior [ ]. Teneurins are a family of phylogenetically conserved transmembrane glycoproteins expressed during pattern formation and mor...

[]

0

[ "PFAM" ]

[ "PF24329" ]

[ "FN-plug_TEN1-4" ]

[ 9313 ]

1

[]

0

[ "6cmx", "6fay", "6fb3", "6ska", "6ske", "6vhh", "7bam", "7ban", "7bao", "8fia", "8r50", "8r51", "8r54" ]

13

[ "PUB00009650", "PUB00012632", "PUB00014529", "PUB00014530", "PUB00014531", "PUB00043665", "PUB00043666", "PUB00043667", "PUB00066375", "PUB00066378", "PUB00155423", "PUB00155629", "PUB00155630" ]

[ "10341219", "12783990", "11146505", "12361962", "10588872", "16406038", "17095284", "17502993", "23028443", "21724987", "29540701", "29414938", "25406022" ]

[ "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.", "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.", "Teneurin-2 is expressed in tissues that regulate limb and...

[ 1999, 2003, 2001, 2002, 1999, 2006, 2007, 2007, 2012, 2011, 2018, 2018, 2015 ]

13

[]

0

null

[ "Bacteria", "Bilateria", "ecological metagenomes" ]

[ 43, 9268, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 144, 7, 12, 11, 35 ]

6

true

Domain

Teneurin 1-4-like, FN-plug domain

FN-plug_TEN1-4

6

IPR057629

57,629

Teneurin-1-4-like, galactose-binding domain-like

Teneurin1-4_GBD

Domain

9,052

false

This galactose-binding domain (GBD) is found in Teneurin-1-4 from Mus musculus (Ten1-4) and its orthologues in animal proteins such as Teneurin a and m in Drosophila melanogaster. Teneurins are a family of phylogenetically conserved transmembrane glycoproteins expressed during pattern formation and morphogenesis [ ]. O...

[]

0

[ "PFAM" ]

[ "PF23093" ]

[ "GBD_Tenm3" ]

[ 9052 ]

1

[]

0

[ "8r50", "8r51", "8r54" ]

3

[ "PUB00009650", "PUB00012632", "PUB00014529", "PUB00014530", "PUB00014531", "PUB00043665", "PUB00043666", "PUB00043667", "PUB00066375", "PUB00066378", "PUB00155423", "PUB00155629", "PUB00155630" ]

[ "10341219", "12783990", "11146505", "12361962", "10588872", "16406038", "17095284", "17502993", "23028443", "21724987", "29540701", "29414938", "25406022" ]

[ "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain.", "The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.", "Teneurin-2 is expressed in tissues that regulate limb and...

[ 1999, 2003, 2001, 2002, 1999, 2006, 2007, 2007, 2012, 2011, 2018, 2018, 2015 ]

13

[]

0

null

[ "Bilateria" ]

[ 9052 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 142, 7, 13, 12, 35 ]

6

true

Domain

Teneurin-1-4-like, galactose-binding domain-like

Teneurin1-4_GBD

5

IPR057630

57,630

Terminase small subunit, actinomycetes phage-type

Terminase_6

Domain

208

false

The small subunit of terminase, a DNA packaging enzyme of bacteriophages, plays a role in binding and cutting the phage DNA during packaging into the capsid. This entry represents diverse small subunits from a wide range of actinobacteriophages and some Bacillota phages. The domain is often found at the N-terminal of p...

[]

0

[ "PFAM" ]

[ "PF23931" ]

[ "Terminase_6" ]

[ 208 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Caudoviricetes" ]

[ 145, 63 ]

2

[]

0

true

Domain

Terminase small subunit, actinomycetes phage-type

Terminase_6

7

IPR057632

57,632

Tubulin polyglutamylase complex subunit 1-like, C-terminal

TPGS1_C

Domain

718

false

This is the C-terminal domain of human TPGS1 and similar animal proteins. This domain is predicted to adopt a mainly α-helical configuration. Tubulin polyglutamylase complex subunit 1-like TPGS1 (also known as PGs1) is part of the tubulin polyglutamylase complex, which plays a role in post-translational addition of glu...

[]

0

[ "PFAM" ]

[ "PF24480" ]

[ "TPGS1_C" ]

[ 718 ]

1

[ "REACTOME" ]

[ "R-HSA-8955332" ]

[ "REACTOME:R-HSA-8955332" ]

1

[]

0

[ "PUB00066565", "PUB00089333" ]

[ "15890843", "12972506" ]

[ "Tubulin polyglutamylase enzymes are members of the TTL domain protein family.", "Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase." ]

[ 2005, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 718 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 2 ]

4

true

Domain

Tubulin polyglutamylase complex subunit 1-like, C-terminal

TPGS1_C

7

IPR057633

57,633

Tumor necrosis factor receptor superfamily member 11B, Death domain

Death_TNF11B

Domain

919

false

This entry represents the Death domains found in two tandem copies at the C-terminal of human Tumor Necrosis Factor Receptor Superfamily Member 11B (TNF11B, also known as osteoprotegerin, OPG) and similar proteins from vertebrates. Death domains typically form an antiparallel α-helical bundle with 6-7 helices arranged ...

[]

0

[ "PFAM" ]

[ "PF23630" ]

[ "Death_TNFRSF11B" ]

[ 919 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5669034", "R-HSA-5669034", "R-MMU-5669034", "R-RNO-5669034" ]

[ "REACTOME:R-BTA-5669034", "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034", "REACTOME:R-RNO-5669034" ]

4

[]

0

[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00053612", "PUB00053613", "PUB00053636", "PUB00053637", "PUB00160553", "PUB00160554" ]

[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "9878548", "11485016", "12124406", "15117849", "16215261", "28765645" ]

[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...

[ 1993, 1994, 2004, 2001, 1998, 1998, 1998, 2001, 2002, 2004, 2005, 2017 ]

12

[]

0

null

[ "Gnathostomata" ]

[ 919 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4 ]

3

true

Domain

Tumor necrosis factor receptor superfamily member 11B, Death domain

Death_TNF11B

1

IPR057634

57,634

ZNF598/HEL2, PAH domain

PAH_ZNF598/HEL2

Domain

4,856

false

This PAH domain is found in the human E3 ubiquitin-protein ligase ZNF598, yeast E3 ubiquitin-protein ligase HEL2 and related eukaryotic proteins. ZNF598 plays a key role in the ribosome quality control (RQC), a pathway that takes place when the ribosome has stalled during translation, leading to degradation of nascent ...

[]

0

[ "PFAM" ]

[ "PF23202" ]

[ "PAH_ZNF598" ]

[ 4856 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00073489", "PUB00092042", "PUB00092043", "PUB00095791", "PUB00155780", "PUB00160555" ]

[ "22570702", "28065601", "22751931", "30609991", "29719242", "28943311" ]

[ "Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.", "Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.", "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian developmen...

[ 2012, 2017, 2012, 2019, 2018, 2017 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4856 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 15, 1, 5, 3, 1, 1, 7, 4, 1, 1, 22 ]

11

true

Domain

ZNF598/HEL2, PAH domain

PAH_ZNF598/HEL2

7

IPR057635

57,635

Tsg, N-terminal

Tsg_N

Domain

1,575

false

This entry represents the N-terminal helical domain of Tsg. This domain forms a compact bundle of three α-helices stabilised by 7 disulphide bonds. This unique fold lacks homology to other known protein structures. This domain occupies the BMP type 1 receptor binding site on BMPs [ ]. Twisted gastrulation (Tsg) was ide...

[]

0

[ "PFAM" ]

[ "PF23782" ]

[ "Tsg_N" ]

[ 1575 ]

1

[]

0

[ "8bwa", "8bwd", "8bwi", "8bwl", "8bwm", "8bwn" ]

6

[ "PUB00008529", "PUB00008530", "PUB00160556" ]

[ "7958834", "11260716", "38862520" ]

[ "Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.", "Twisted gastrulation is a conserved extracellular BMP antagonist.", "Molecular mechanism of BMP signal control by Twisted gastrulation." ]

[ 1994, 2001, 2024 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 1575 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 3, 2, 1, 3 ]

5

true

Domain

Tsg, N-terminal

Tsg_N

1

IPR057636

57,636

Zona pellucida sperm-binding protein 2, third Ig-like domain

Ig_ZP2_3rd

Domain

794

false

This entry represents the third Ig-like domain at the N-terminal in Zona pellucida sperm-binding protein 2 (ZP2) from mouse and similar proteins from vertebrates [ ]. ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding and induction of the acrosome reaction...

[]

0

[ "PFAM" ]

[ "PF23740" ]

[ "Ig_ZP2_3rd" ]

[ 794 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2534343", "R-MMU-2534343", "R-SSC-2534343" ]

[ "REACTOME:R-HSA-2534343", "REACTOME:R-MMU-2534343", "REACTOME:R-SSC-2534343" ]

3

[ "8rke", "8rkg", "8rkh" ]

3

[ "PUB00090694", "PUB00155680", "PUB00160747" ]

[ "25445843", "28622512", "22734000" ]

[ "Role of zona pellucida glycoproteins during fertilization in humans.", "Structural Basis of Egg Coat-Sperm Recognition at Fertilization.", "Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice." ]

[ 2015, 2017, 2012 ]

3

[]

0

null

[ "Euteleostomi" ]

[ 794 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 8 ]

3

true

Domain

Zona pellucida sperm-binding protein 2, third Ig-like domain

Ig_ZP2_3rd

2

IPR057637

57,637

Zona pellucida sperm-binding protein 2, first Ig-like domain

Ig_ZP2_1st

Domain

640

false

This entry represents the first Ig-like domain at the N-terminal in Zona pellucida sperm-binding protein 2 (ZP2) from mouse and similar proteins from vertebrates [ ]. ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding and induction of the acrosome reaction...

[]

0

[ "PFAM" ]

[ "PF23738" ]

[ "Ig_ZP2_N" ]

[ 640 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2534343", "R-MMU-2534343", "R-SSC-2534343" ]

[ "REACTOME:R-HSA-2534343", "REACTOME:R-MMU-2534343", "REACTOME:R-SSC-2534343" ]

3

[ "5ii6", "8rke", "8rkf", "9h4r", "9h4s" ]

5

[ "PUB00090694", "PUB00155680", "PUB00160747" ]

[ "25445843", "28622512", "22734000" ]

[ "Role of zona pellucida glycoproteins during fertilization in humans.", "Structural Basis of Egg Coat-Sperm Recognition at Fertilization.", "Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice." ]

[ 2015, 2017, 2012 ]

3

[]

0

null

[ "Tetrapoda" ]

[ 640 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 8 ]

3

true

Domain

Zona pellucida sperm-binding protein 2, first Ig-like domain

Ig_ZP2_1st

4

IPR057638

57,638

Zona pellucida sperm-binding protein 2, second Ig-like domain

Ig_ZP2_2nd

Domain

893

false

This entry represents the second Ig-like domain at the N-terminal in Zona pellucida sperm-binding protein 2 (ZP2) from mouse and similar proteins from vertebrates [ ]. ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding and induction of the acrosome reactio...

[]

0

[ "PFAM" ]

[ "PF23736" ]

[ "Ig_ZP2" ]

[ 893 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2534343", "R-MMU-2534343", "R-SSC-2534343" ]

[ "REACTOME:R-HSA-2534343", "REACTOME:R-MMU-2534343", "REACTOME:R-SSC-2534343" ]

3

[ "8rke", "8rkf", "8rkg", "8rkh" ]

4

[ "PUB00090694", "PUB00155680", "PUB00160747" ]

[ "25445843", "28622512", "22734000" ]

[ "Role of zona pellucida glycoproteins during fertilization in humans.", "Structural Basis of Egg Coat-Sperm Recognition at Fertilization.", "Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice." ]

[ 2015, 2017, 2012 ]

3

[]

0

null

[ "Vertebrata" ]

[ 893 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 8 ]

3

true

Domain

Zona pellucida sperm-binding protein 2, second Ig-like domain

Ig_ZP2_2nd

1

IPR057639

57,639

TXNDC16, N-terminal

TXNDC16_N

Domain

975

false

This entry represents the N-terminal domain of TXNDC16. This domain adopts a thioredoxin-like fold. TXNDC genes are members of the thioredoxin superfamily and were shown to play a role in redox homeostasis, protein folding, electron transfer, and also acting as cellular adapters. However, the function of TXDNC16 is sti...

[]

0

[ "PFAM" ]

[ "PF24508" ]

[ "TXNDC16_N" ]

[ 975 ]

1

[]

0

[]

0

[ "PUB00090994", "PUB00160557" ]

[ "25122923", "36106447" ]

[ "Secretion and immunogenicity of the meningioma-associated antigen TXNDC16.", "Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis." ]

[ 2014, 2023 ]

2

[]

0

null

[ "Eukaryota" ]

[ 975 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 4, 2 ]

4

true

Domain

TXNDC16, N-terminal

TXNDC16_N

3

IPR057640

57,640

WalK sensor protein kinase, cache domain

Cache_WalK

Domain

2,729

false

This entry represents the Cache domain found in the sensor protein kinase WalK (or YycG) from bacteria, mainly from firmicutes. This domain is extracellular and is involved in WalK dimerisation necessary for protein function [ ]. The WalK protein, alongside its response regulator WalR, is a member of the two-component ...

[]

0

[ "PFAM" ]

[ "PF23846" ]

[ "Cache_WalK" ]

[ 2729 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "4ywz", "5is1", "7dud" ]

3

[ "PUB00127901", "PUB00150867", "PUB00153119", "PUB00153524", "PUB00155563", "PUB00155564" ]

[ "17581128", "12950927", "35575581", "17827301", "22825451", "27389096" ]

[ "The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis.", "Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach.", "The WalRK Two-Component System Is Essential for Proper Cell Envelope Bioge...

[ 2007, 2003, 2022, 2007, 2012, 2016 ]

6

[]

0

null

[ "Bacteria", "Ecdysozoa", "Halovenus aranensis", "ecological metagenomes" ]

[ 2723, 2, 1, 3 ]

4

[]

0

true

Domain

WalK sensor protein kinase, cache domain

Cache_WalK

2

IPR057641

57,641

W02B3.4-like, N-terminal domain

W02B3_4_N

Domain

222

false

This domain is found at the N-terminal end of the uncharacterised protein W02B3.4 from Caenorhabditis elegans and similar animal proteins. This domain is predicted to adopt an α-β fold.

[]

0

[ "PFAM" ]

[ "PF24413" ]

[ "W02B3_4_N" ]

[ 222 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 222 ]

1

[ "Caenorhabditis elegans" ]

[ 5 ]

1

true

Domain

W02B3.4-like, N-terminal domain

W02B3_4_N

1

IPR057642

57,642

TXNDC16, second thioredoxin-like domain

TXNDC16_2nd

Domain

1,056

false

This entry represents the second thioredoxin-like domain of TXNDC16. The function of this domain is unknown. It contains an α+β three layer fold. TXNDC genes are members of the thioredoxin superfamily and were shown to play a role in redox homeostasis, protein folding, electron transfer, and also acting as cellular ada...

[]

0

[ "PFAM" ]

[ "PF24509" ]

[ "TXNDC16_2nd" ]

[ 1056 ]

1

[]

0

[]

0

[ "PUB00090994", "PUB00160557" ]

[ "25122923", "36106447" ]

[ "Secretion and immunogenicity of the meningioma-associated antigen TXNDC16.", "Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis." ]

[ 2014, 2023 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1056 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 3, 2 ]

4

true

Domain

TXNDC16, second thioredoxin-like domain

TXNDC16_2nd

6

IPR057644

57,644

WD repeat-containing protein 75, second beta-propeller

Beta-prop_WDR75_2nd

Domain

3,586

false

This entry represents the second β-propeller found in WD repeat-containing protein 75 (WDR75) from animals. The function of this domain is unknown. This domain is also found in U3 small nucleolar RNA-associated protein 13 and 17 (UTP13 and UTP17), which are WDR75 orthologs from yeast. WDR75 is an essential factor in th...

[]

0

[ "PFAM" ]

[ "PF23769" ]

[ "Beta-prop_WDR75_2nd" ]

[ 3586 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

5

[ "5wyj", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "7ajt", "7aju", "7d4i", "7d5s", "7d5t", "7d63", "7mq8", "7mq9", "7mqa", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z"...

39

[ "PUB00155547", "PUB00160558" ]

[ "34611297", "39932919" ]

[ "RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.", "WDR75: An essential protein for ribosome assembly undergoing purifying selection." ]

[ 2022, 2025 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3586 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 14, 2, 2, 2, 7, 4, 3, 1, 1, 7 ]

10

true

Domain

WD repeat-containing protein 75, second beta-propeller

Beta-prop_WDR75_2nd

7

IPR057645

57,645

TXNDC16, third thioredoxin-like domain

TXNDC16_3rd

Domain

947

false

This entry represents the third thioredoxin-like domain of TXNDC16. The function of this domain is unknown. It contains a α+β three layer fold. This domain is found next to the thioredoxin domain . TXNDC genes are members of the thioredoxin superfamily and were shown to play a role in redox homeostasis, protein folding...

[]

0

[ "PFAM" ]

[ "PF24510" ]

[ "TXNDC16_3rd" ]

[ 947 ]

1

[]

0

[]

0

[ "PUB00090994", "PUB00160557" ]

[ "25122923", "36106447" ]

[ "Secretion and immunogenicity of the meningioma-associated antigen TXNDC16.", "Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis." ]

[ 2014, 2023 ]

2

[]

0

null

[ "Vertebrata" ]

[ 947 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 2, 2 ]

4

true

Domain

TXNDC16, third thioredoxin-like domain

TXNDC16_3rd

9

IPR057646

57,646

WDHD1, first WD40 domain

WD40_WDHD1_1st

Domain

3,946

false

This entry represents the WD40 domain found at the N-terminal of WDHD1 (also known as AND-1), Protein ENHANCER OF LHP1 1 and Minichromosome loss protein 1. WDHD1 is an adaptor molecule crucial for DNA replication [ , ]. It is a core replisome component that acts as a replication initiation factor. It binds directly to ...

[]

0

[ "PFAM" ]

[ "PF24817" ]

[ "WD40_WDHD1_1st" ]

[ 3946 ]

1

[]

0

[ "5gva", "6xty", "7pfo", "7plo", "8b9d" ]

5

[ "PUB00151993", "PUB00151996", "PUB00154917" ]

[ "28381552", "35585232", "34694004" ]

[ "The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.", "Fast and efficient DNA replication with purified human proteins.", "Structure of a human replisome shows the organisation and interactions of a DNA replication machine." ]

[ 2017, 2022, 2021 ]

3

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 12, 3934 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 3, 2, 4, 3, 1, 2, 4, 1, 6 ]

11

true

Domain

WDHD1, first WD40 domain

WD40_WDHD1_1st

5

IPR057648

57,648

U exon-like

U_exon-like

Family

38

false

This protein family includes U exon protein from Fowl aviadenovirus 4 and similar viral short sequences [ ].

[]

0

[ "PFAM" ]

[ "PF23683" ]

[ "U_exon" ]

[ 38 ]

1

[]

0

[]

0

[ "PUB00155774" ]

[ "36851744" ]

[ "Analysis of Fowl Adenovirus 4 Transcriptome by De Novo ORF Prediction Based on Corrected Nanopore Full-Length cDNA Sequencing Data." ]

[ 2023 ]

1

[]

0

null

[ "Aviadenovirus" ]

[ 38 ]

1

[]

0

true

Family

U exon-like

U_exon-like

6

IPR057649

57,649

PUB 62/63, C-terminal

PUB62-63_C

Domain

1,328

false

This is a domain found at the C-terminal of Plant U-Box 62/63 (PUB62/63) from Arabidopsis thaliana and similar proteins from plants. According to structure predictions, this domain may adopt an SH3-like barrel fold. The U-box domain-containing proteins function as E3 ubiquitin ligases. These proteins play a crucial rol...

[]

0

[ "PFAM" ]

[ "PF23112" ]

[ "PUB62-63_C" ]

[ 1328 ]

1

[]

0

[]

0

[ "PUB00155815" ]

[ "29237060" ]

[ "News from the PUB: plant U-box type E3 ubiquitin ligases." ]

[ 2018 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 1328 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 6, 12 ]

3

true

Domain

PUB 62/63, C-terminal

PUB62-63_C

4

IPR057650

57,650

UBAC1, ubiquitin-like domain

UBL_UBAC1

Domain

1,312

false

This domain is found in human UBAC1 (Ubiquitin-associated domain-containing protein 1) and related animal proteins. This domain shares significant sequence similarity with ubiquitin-like domains, and it is predicted to adopt a similar structure with ubiquitin fold topology. Ubiquitin-associated domain-containing protei...

[]

0

[ "PFAM" ]

[ "PF23326" ]

[ "UBL_UBAC1" ]

[ 1312 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168", "R-RNO-983168", "R-XTR-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-983168", "REACTOME:R-XTR-983168" ]

4

[]

0

[ "PUB00086162", "PUB00135879" ]

[ "15531880", "16227581" ]

[ "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.", "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1312 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 5, 2, 1, 8 ]

5

true

Domain

UBAC1, ubiquitin-like domain

UBL_UBAC1

7

IPR057651

57,651

TPPC8, C-terminal Ig-like domain

Ig_TPPC8_C

Domain

2,903

false

This entry represents an Ig-like domain found at the C-terminal of TPPC8. TPPC8 plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage [ ]. Together with TBC1D14, it maintains the cycling pool of ATG9 required for initiation of autophagy [ ]. It is one of the TRAPPIII complex specifi...

[]

0

[ "PFAM" ]

[ "PF24542" ]

[ "Ig_TPPC8_C" ]

[ 2903 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-8876198", "R-HSA-8876198" ]

[ "REACTOME:R-CEL-8876198", "REACTOME:R-HSA-8876198" ]

2

[]

0

[ "PUB00075414", "PUB00155679" ]

[ "21525244", "26711178" ]

[ "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.", "TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2903 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 5, 3, 5, 4, 5, 4 ]

8

true

Domain

TPPC8, C-terminal Ig-like domain

Ig_TPPC8_C

9

IPR057652

57,652

RDM1, DSRM domain

DSRM_RDM1

Domain

981

false

This entry represents a domain found in the human RDM1 (RAD52 Motif Containing 1) and related proteins. RDM1 is a protein involved in cellular responses to DNA damage and stress. It can bind to RNA, single-stranded DNA (ssDNA), and double-stranded DNA (dsDNA) [ ]. RDM1 plays a role in the cellular response to cisplatin...

[]

0

[ "PFAM" ]

[ "PF25517" ]

[ "DSRM_RDM1" ]

[ 981 ]

1

[]

0

[]

0

[ "PUB00082860", "PUB00090717", "PUB00128338" ]

[ "15611051", "30069034", "17905820" ]

[ "RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates.", "RDM1 plays an oncogenic role in human lung adenocarcinoma cells.", "Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and p...

[ 2005, 2018, 2007 ]

3

[]

0

null

[ "Eukaryota" ]

[ 981 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 7 ]

4

true

Domain

RDM1, DSRM domain

DSRM_RDM1

2

IPR057653

57,653

YeeW-like domain

YeeW-like_dom

Domain

720

false

This domain is found covering the whole length of Protein YeeW from Escherichia coli and at the N-terminal end of sequences that also have . It likely forms a homodimeric structure composed of three β-strands provided by each monomer, with one strand swapped with the other monomer. Members of this group are proteobacte...

[]

0

[ "PFAM" ]

[ "PF25638" ]

[ "DUF5983_N" ]

[ 720 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacterales", "human gut metagenome" ]

[ 719, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YeeW-like domain

YeeW-like_dom

5

IPR057654

57,654

Tandem CCCH zinc finger domains

Znf-CCCH_tandem

Domain

2,577

false

This pair of CCCH zinc finger domains is found in uncharacterised fungal proteins.

[]

0

[ "PFAM" ]

[ "PF25543" ]

[ "zf-CCCH_tandem" ]

[ 2577 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2577 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Tandem CCCH zinc finger domains

Znf-CCCH_tandem

8

IPR057655

57,655

STIL, coiled coil region

STIL_CC

Domain

854

false

This coiled-coil region is found in the human SCL/TAL1 interrupting locus (STIL) protein and homologues. This region interacts with the Polo-like kinase 4 (PLK4) and binds to its Polo-box 3 (PB3) domain. It also uses a secondary interaction site in the PLK4 L1 region [ ]. This CC_STIL/PLK4 interaction mediates PLK4 act...

[]

0

[ "PFAM" ]

[ "PF25775" ]

[ "CC_STIL" ]

[ 854 ]

1

[]

0

[ "4yyp", "5lhw", "5lhz", "8oyk", "8oyl" ]

5

[ "PUB00053803", "PUB00060062", "PUB00060063", "PUB00060064", "PUB00060066", "PUB00060086", "PUB00160597" ]

[ "12006978", "17576815", "11668681", "19215732", "8825637", "16024801", "26188084" ]

[ "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.", "The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.", "Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.", "Mutations in STIL, ...

[ 2002, 2007, 2001, 2009, 1995, 2005, 2015 ]

7

[]

0

null

[ "Bilateria" ]

[ 854 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 11, 4, 2 ]

4

true

Domain

STIL, coiled coil region

STIL_CC

3

IPR057656

57,656

CEP63/Deup1, CEP152 binding coiled coil

CEP63/Deup1_CC

Domain

1,877

false

This coiled-coil domain is found in the human centrosomal protein 63 kDa (CEP63), its paralogue Deuterosome assembly protein 1 (Deup1) and homologues. In CEP63 this coiled-coil region interacts with the coiled-coil region of the centrosomal protein 152 kDa (CEP152) [ ]. Both proteins cooperatively form a heterotetramer...

[]

0

[ "PFAM" ]

[ "PF25771" ]

[ "CC_CEP152-bind" ]

[ 1877 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-2565942", "R-GGA-380259", "R-GGA-380270", "R-GGA-380284", "R-GGA-380320", "R-GGA-5620912", "R-GGA-8854518", "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-...

[ "REACTOME:R-GGA-2565942", "REACTOME:R-GGA-380259", "REACTOME:R-GGA-380270", "REACTOME:R-GGA-380284", "REACTOME:R-GGA-380320", "REACTOME:R-GGA-5620912", "REACTOME:R-GGA-8854518", "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA...

28

[ "6csu", "6csv" ]

2

[ "PUB00070542", "PUB00160593" ]

[ "24240477", "30858376" ]

[ "The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.", "Molecular architecture of a cylindrical self-assembly at human centrosomes." ]

[ 2013, 2019 ]

2

[]

0

null

[ "Bilateria", "Vogesella fluminis" ]

[ 1876, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 12, 6, 12 ]

4

true

Domain

CEP63/Deup1, CEP152 binding coiled coil

CEP63/Deup1_CC

1

IPR057657

57,657

MAT1, C-terminal CAK anchor

MAT1_CAK-anch

Domain

1,439

false

This entry represents a region, known as CAK anchor, located toward the C-terminal of the human CDK-activating kinase assembly factor MAT1 and related proteins. The CAK anchor region of MAT1 binds between the C-terminal lobes of CDK7 and cyclin H, enhancing CDK7 kinase activity by positioning its activation loop in a c...

[]

0

[ "PFAM" ]

[ "PF25811" ]

[ "CAK-anch_MAT1" ]

[ 1439 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-112382", "R-HSA-113418", "R-HSA-167152", "R-HSA-167158", "R-HSA-167160", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-167200", "R-HSA-167246", "R-HSA-427413", "R-HSA-5696395", "R-HSA-674695", "R-HSA-6781823", "R-HSA-6781827", "R-HSA-6782135", "R-HSA-6782210", "R-HS...

[ "REACTOME:R-HSA-112382", "REACTOME:R-HSA-113418", "REACTOME:R-HSA-167152", "REACTOME:R-HSA-167158", "REACTOME:R-HSA-167160", "REACTOME:R-HSA-167161", "REACTOME:R-HSA-167162", "REACTOME:R-HSA-167172", "REACTOME:R-HSA-167200", "REACTOME:R-HSA-167246", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-569...

56

[ "6nmi", "6o9l", "6o9m", "6xbz", "6xd3", "7b5o", "7b5q", "7egb", "7egc", "7ena", "7enc", "7lbm", "7nvr", "7nvw", "7nvx", "7nvy", "7nvz", "7nw0", "8bvw", "8byq", "8gxq", "8gxs", "8orm", "8p6v", "8p6w", "8p6x", "8p6y", "8p6z", "8p70", "8p71", "8p72", "8p73"...

60

[ "PUB00007681", "PUB00007682", "PUB00160591", "PUB00160592" ]

[ "11007478", "11447116", "32855301", "33055219" ]

[ "Molecular structure of human TFIIH.", "T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.", "The cryoelectron microscopy structure of the human CDK-activating kinase.", "Structural basis for CDK7 activation by MAT1 and Cyclin H." ]

[ 2000, 2001, 2020, 2020 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1439 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 2, 2, 3, 1, 4 ]

7

true

Domain

MAT1, C-terminal CAK anchor

MAT1_CAK-anch

5

IPR057658

57,658

CEP250, coiled coil

CEP250_CC

Domain

775

false

This domain is found in the human Centrosomal protein 250 kDa (CEP250) and its homologues mainly from vertebrates. CEP250 plays an important role in centrosome cohesion during interphase by recruiting CCDC102B to the proximal ends of centriole [ ]. This domain interacts with FKBP12 and this interaction is mediated by s...

[]

0

[ "PFAM" ]

[ "PF25774" ]

[ "CC_CEP250" ]

[ 775 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380284", "REACTOME:R-MMU...

14

[ "6oqa" ]

1

[ "PUB00154894", "PUB00160594" ]

[ "30404835", "32606248" ]

[ "CCDC102B functions in centrosome linker assembly and centrosome cohesion.", "Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface." ]

[ 2018, 2020 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 775 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 1 ]

3

true

Domain

CEP250, coiled coil

CEP250_CC

1

IPR057659

57,659

CEP152, CEP63 binding coiled coil

CEP152_CC

Domain

1,112

false

This coiled-coil domain is found in the human centrosomal protein 152 kDa (CEP152) and homologues. It interacts with the coiled-coil region of the centrosomal protein 63 kDa (CEP63) [ ]. Both proteins cooperatively form a heterotetrameric α-helical bundle. This complex functions in conjunction with its neighbouring hyd...

[]

0

[ "PFAM" ]

[ "PF25770" ]

[ "CC_CEP63-bind_CEP152" ]

[ 1112 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380284", "REACTOME:R-MMU...

14

[ "6csu", "6csv" ]

2

[ "PUB00160593" ]

[ "30858376" ]

[ "Molecular architecture of a cylindrical self-assembly at human centrosomes." ]

[ 2019 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1112 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 1, 3 ]

4

true

Domain

CEP152, CEP63 binding coiled coil

CEP152_CC

9

IPR057661

57,661

RsdA/BaiN/AoA(So)-like, Rossmann fold-like domain

RsdA/BaiN/AoA(So)_Rossmann

Domain

24,881

false

This entry represents a Rossmann fold-like domain surrounding two structural (β-barrel and H2TH α-helical) domains . This domain is found in 3-dehydro-bile acid delta(4,6)-reductase from Clostridium scindens (BaiN), Ribosomal RNA dihydrouridine synthase (rdsA) from Escherichia coli and Aminoacetone oxidase (aao(So)) fr...

[]

0

[ "PFAM" ]

[ "PF03486" ]

[ "HI0933_like" ]

[ 24881 ]

1

[]

0

[ "2gqf", "2i0z", "3v76", "4cnj", "4cnk" ]

5

[ "PUB00090979", "PUB00106457", "PUB00160761", "PUB00160762", "PUB00160763" ]

[ "29217478", "25269103", "18469105", "22666463", "39078675" ]

[ "Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704.", "Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins.", "SO-LAAO, a novel L-amino acid oxidase that...

[ 2018, 2014, 2008, 2012, 2024 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 23598, 902, 97, 284 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 5, 9 ]

4

true

Domain

RsdA/BaiN/AoA(So)-like, Rossmann fold-like domain

RsdA/BaiN/AoA(So)_Rossmann

2

IPR057663

57,663

TACC3, Aurora-A binding region

TACC3_Aurora-A_bind

Binding_site

1,119

false

This region is found in the human Transforming acidic coiled-coil-containing protein 3 (TACC3) and homologues. Phosphorylation of human TACC3 on S558 (located within this region) drives an interaction with the ankle region of the clathrin heavy chain (CHC) to form a complex that binds the microtubule lattice through th...

[]

0

[ "PFAM" ]

[ "PF25777" ]

[ "Aurora-A_bind_TACC3" ]

[ 1119 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9013507", "R-HSA-9604323" ]

[ "REACTOME:R-HSA-9013507", "REACTOME:R-HSA-9604323" ]

2

[ "5ods", "5odt" ]

2

[ "PUB00160573", "PUB00160574" ]

[ "20923838", "29510984" ]

[ "Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment.", "Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix." ]

[ 2010, 2018 ]

2

[]

0

null

[ "Metazoa" ]

[ 1119 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 6, 5 ]

4

true

Binding_site

TACC3, Aurora-A binding region

TACC3_Aurora-A_bind

5

IPR057664

57,664

CEP152, PLK4 binding region

CEP152_PLK4_bind

Binding_site

936

false

This region is found in human Centrosomal protein 152 kDa (CEP152) and homologues. This region bind the cryptic polo box (CPB) of Polo-like kinase 4 (Plk4) in opposite orientations and in a mutually exclusive manner to Centrosomal protein 152 kDa (152) [ ]. Plk4 is a key regulator of centriole duplication, an event cri...

[]

0

[ "PFAM" ]

[ "PF25769" ]

[ "PLK4_bind_CEP152" ]

[ 936 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380284", "REACTOME:R-MMU...

14

[ "4n7v" ]

1

[ "PUB00148286" ]

[ "24997597" ]

[ "Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis." ]

[ 2014 ]

1

[]

0

null

[ "Bilateria" ]

[ 936 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 1, 2 ]

4

true

Binding_site

CEP152, PLK4 binding region

CEP152_PLK4_bind

9

IPR057665

57,665

CEP192, PLK4 binding region

CEP192_PLK4_bind

Binding_site

1,065

false

This region is found in human Centrosomal protein 192 kDa (CEP192) and homologues. This region bind the cryptic polo box (CPB) of Polo-like kinase 4 (Plk4) in opposite orientations and in a mutually exclusive manner to Centrosomal protein 152 kDa (152) [ ]. Plk4 is a key regulator of centriole duplication, an event cri...

[]

0

[ "PFAM", "CDD" ]

[ "PF25765", "cd21856" ]

[ "PLK4_bind_CEP192", "Plk4BD_Cep192" ]

[ 1009, 757 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518" ]

7

[ "4n7z", "6w3j" ]

2

[ "PUB00060222", "PUB00068669", "PUB00068670", "PUB00148286", "PUB00148287", "PUB00148288", "PUB00148289", "PUB00148290", "PUB00148291", "PUB00148292", "PUB00148293", "PUB00148294", "PUB00148295", "PUB00148296" ]

[ "14654843", "17980596", "18207742", "24997597", "23932902", "28970258", "21097701", "18469523", "28188792", "24971877", "22895009", "25042804", "26012549", "26119750" ]

[ "Proteomic characterization of the human centrosome by protein correlation profiling.", "Human Cep192 is required for mitotic centrosome and spindle assembly.", "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.", "Molecular basis for unidirectional scaffold switching of human Plk4 in centr...

[ 2003, 2007, 2008, 2014, 2013, 2018, 2010, 2008, 2017, 2014, 2012, 2014, 2015, 2015 ]

14

[]

0

null

[ "Gnathostomata" ]

[ 1065 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 21, 3, 2, 3 ]

4

true

Binding_site

CEP192, PLK4 binding region

CEP192_PLK4_bind

9

IPR057666

57,666

Smf/DprA, SLOG domain

DrpA_SLOG

Domain

29,968

false

This entry describes the SLOG domain in prokaryotic proteins. This domain adopts a three-layered α/β sandwich Rossmann fold with a characteristic substrate-binding loop rich in glycine and small residues in the standard location between strand-1 and helix-1. This domain is found in DNA processing protein A (DprA) from ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF02481", "TIGR00732" ]

[ "DNA_processg_A", "dprA" ]

[ 29968, 24713 ]

2

[]

0

[ "3maj", "3uqz", "4ljk", "4ljl", "4ljr", "5mll", "8zva" ]

7

[ "PUB00009463", "PUB00017569", "PUB00017570", "PUB00017571", "PUB00017572", "PUB00044733", "PUB00078829" ]

[ "10640603", "7768823", "10482496", "12123453", "14617176", "17803906", "23440217" ]

[ "The dprA gene is required for natural transformation of Helicobacter pylori.", "DNA sequence and characterization of Haemophilus influenzae dprA+, a gene required for chromosomal but not plasmid DNA transformation.", "HP0333, a member of the dprA family, is involved in natural transformation in Helicobacter py...

[ 2000, 1995, 1999, 2002, 2003, 2007, 2013 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 51, 29263, 48, 14, 592 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Smf/DprA, SLOG domain

DrpA_SLOG

7

IPR057667

57,667

Sleeping Beauty transposase, HTH domain

HTH_SB

Domain

10,800

false

This entry represents the helix-turn-helix (HTH) domain, also known as PAI subdomain, found in Sleeping Beauty transposase and homologues. This domain improves the enzyme structural stability and transposon DNA-binding.

[]

0

[ "PFAM" ]

[ "PF25787" ]

[ "HTH_SB" ]

[ 10800 ]

1

[]

0

[ "2m8e", "6urs" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 10800 ]

1

[ "Danio rerio" ]

[ 5 ]

1

true

Domain

Sleeping Beauty transposase, HTH domain

HTH_SB

2

IPR057668

57,668

Non-canonical E2 ubiquitin-conjugating enzyme, C-terminal

E2_Ub-conjug_enz_C

Domain

1,308

false

This entry describes a domain found at the C-terminal end in a novel group of non-canonical E2 ubiquitin-conjugating proteins that lack the typical HPN motif found in conventional E2 enzymes, including from Plasmodium falciparum and similar proteins mainly from in Apicomplexan parasites, fungi and some amoeba species. ...

[]

0

[ "PFAM" ]

[ "PF09418" ]

[ "DUF2009" ]

[ 1308 ]

1

[]

0

[]

0

[ "PUB00160741" ]

[ "40249735" ]

[ "Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium." ]

[ 2025 ]

1

[]

0

null

[ "Eukaryota", "uncultured organism MedDCM-OCT-S04-C2" ]

[ 1307, 1 ]

2

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2 ]

1

true

Domain

Non-canonical E2 ubiquitin-conjugating enzyme, C-terminal

E2_Ub-conjug_enz_C

7

IPR057669

57,669

P3, C-terminal domain

P3_C

Domain

9

false

This entry represents the C-terminal domain of the Major capsid protein P3. The P3 major capsid protein adopts a 'double-sandwich' structure comprising two eight-stranded viral β-sandwich domains with a jellyroll fold, each of which contains a 12-residue α-helix. This protein trimerises through a 'trimerisation loop' s...

[]

0

[ "PFAM" ]

[ "PF25514" ]

[ "P3_C" ]

[ 9 ]

1

[]

0

[ "1cjd", "1gw7", "1gw8", "1hb5", "1hb7", "1hb9", "1hqn", "1hx6", "1w8x", "6q5u", "7ook" ]

11

[ "PUB00028629" ]

[ "11752778" ]

[ "The X-ray crystal structure of P3, the major coat protein of the lipid-containing bacteriophage PRD1, at 1.65 A resolution." ]

[ 2002 ]

1

[]

0

null

[ "Tectiviridae" ]

[ 9 ]

1

[]

0

true

Domain

P3, C-terminal domain

P3_C

9

IPR057671

57,671

BRINP, C-terminal domain

BRINP_C

Domain

3,292

false

This entry represents the C-terminal domain of BMP/retinoic acid-inducible neural-specific protein (BRINP) 1, 2 and 3. BRINP proteins are involved in neurogenesis and brain development. These proteins play a role in inhibiting neuronal cell proliferation by negatively regulating cell cycle progression, particularly by ...

[]

0

[ "PFAM" ]

[ "PF19052" ]

[ "BRINP_C" ]

[ 3292 ]

1

[]

0

[]

0

[ "PUB00078235", "PUB00078236", "PUB00160495" ]

[ "11420708", "20025061", "15193423" ]

[ "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.", "Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.", "Identification and characterization of novel developmental...

[ 2001, 2010, 2004 ]

3

[]

0

null

[ "Chordata" ]

[ 3292 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 7, 3, 9 ]

4

true

Domain

BRINP, C-terminal domain

BRINP_C

8

IPR057672

57,672

IPO4/5-like, TPR repeats domain

TPR_IPO4/5

Domain

12,438

false

This region of tetratricopeptide (TPR)-like repeats is found towards the N-terminal end of human Importin-4/5 (IPO4/5) and similar eukaryotic proteins. IPO4 serves as receptor for nuclear localisation signals in cargo substrates [ , ].

[]

0

[ "PFAM" ]

[ "PF25780" ]

[ "TPR_IPO5" ]

[ 12438 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-450513", "R-HSA-192905", "R-HSA-450513", "R-HSA-5620924", "R-HSA-9615933", "R-MMU-450513", "R-MMU-5620924", "R-SPO-450513" ]

[ "REACTOME:R-BTA-450513", "REACTOME:R-HSA-192905", "REACTOME:R-HSA-450513", "REACTOME:R-HSA-5620924", "REACTOME:R-HSA-9615933", "REACTOME:R-MMU-450513", "REACTOME:R-MMU-5620924", "REACTOME:R-SPO-450513" ]

8

[ "1qbk", "2h4m", "2ot8", "2qmr", "2z5j", "2z5k", "2z5m", "2z5n", "2z5o", "3w3t", "3w3u", "3w3v", "3w3w", "3w3x", "3w3y", "3w3z", "4fdd", "4fq3", "4jlq", "4oo6", "4zj7", "5h2v", "5j3v", "5tqc", "5vch", "5ve8", "5w0v", "5yvg", "5yvh", "5yvi", "6xte", "6xu2"...

38

[ "PUB00030197", "PUB00030257", "PUB00031678", "PUB00039663", "PUB00041276", "PUB00160697", "PUB00160731", "PUB00160732" ]

[ "10353245", "10353244", "15537541", "15864302", "16901787", "32222384", "11823430", "16207705" ]

[ "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.", "Structure of importin-beta bound to the IBB domain of importin-alpha.", "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.", "Structural ...

[ 1999, 1999, 2004, 2005, 2006, 2020, 2002, 2005 ]

8

[]

0

null

[ "Eukaryota" ]

[ 12438 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 4, 10, 15, 11, 2, 15, 17, 2, 3, 45 ]

12

true

Domain

IPO4/5-like, TPR repeats domain

TPR_IPO4/5

9

IPR057674

57,674

RBM22, CCCH zinc finger domain

Znf-CCCH_RBM22

Domain

1,801

false

This CCCH-type zinc finger domain is found in human Pre-mRNA-splicing factor RBM22 and similar animal proteins. RBM22 is required for pre-mRNA splicing as component of the activated spliceosome [ , ]. It is involved in the first step of pre-mRNA splicing. RBM22 binds directly to the internal stem-loop (ISL) domain of t...

[]

0

[ "PFAM" ]

[ "PF25584" ]

[ "zf-CCCH_RBM22" ]

[ 1801 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163", "R-XTR-72163" ]

[ "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163", "REACTOME:R-XTR-72163" ]

5

[ "5mqf", "5xjc", "5yzg", "5z56", "5z57", "6ff4", "6ff7", "6icz", "6id0", "6id1", "6qdv", "6zym", "7a5p", "7aav", "7abg", "7abi", "7qtt", "7w59", "7w5a", "7w5b", "8c6j", "8ch6", "8i0p", "8i0r", "8i0s", "8i0t", "8i0u", "8i0v", "8i0w", "8ro0", "8ro1", "8ro2"...

33

[ "PUB00092514", "PUB00097019" ]

[ "28502770", "28076346" ]

[ "An Atomic Structure of the Human Spliceosome.", "Cryo-EM structure of a human spliceosome activated for step 2 of splicing." ]

[ 2017, 2017 ]

2

[ "IPR000571" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1801 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 2, 1, 3 ]

6

true

Domain

RBM22, CCCH zinc finger domain

Znf-CCCH_RBM22

5

IPR057676

57,676

STK11-interacting protein, C-terminal PH domain

PH_S11IP_C

Domain

1,271

false

This entry represents a pleckstrin homology (PH) domain found in human STK11-interacting protein (S11IP) and related proteins. STK11IP interacts with the serine/threonine kinase 11 (STK11), also known as liver kinase B1 (LKB1). This interaction is important for several cellular processes, including protein localisation...

[]

0

[ "PFAM" ]

[ "PF25624" ]

[ "PH_S11IP_C" ]

[ 1271 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-MMU-6798695", "R-XTR-6798695" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-XTR-6798695" ]

3

[]

0

[ "PUB00076051" ]

[ "11741830" ]

[ "LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1271 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 3, 1, 5 ]

5

true

Domain

STK11-interacting protein, C-terminal PH domain

PH_S11IP_C

7

IPR057677

57,677

EndoE-GH18L, 2nd helical domain

EndoE-GH18L_3HB-2

Domain

50

false

This domain is the second helical domain (3HB-2) found in EndoE. It forms specific inter-domain interactions with 3HB-1 through hydrogen bonds and provides the architectural framework necessary for cooperative substrate processing in the full-length enzyme. The 3HB-2 domain is essential for positioning the GH18 and GH2...

[]

0

[ "PFAM" ]

[ "PF25528" ]

[ "DUF7917" ]

[ 50 ]

1

[]

0

[ "7puj", "7puk" ]

2

[ "PUB00120398", "PUB00155713", "PUB00160953" ]

[ "11406581", "12438337", "35241669" ]

[ "EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG.", "EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin-mediated opsonophagocytosis.", "Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE." ]

[ 2001, 2002, 2022 ]

3

[]

0

null

[ "Bacillati" ]

[ 50 ]

1

[]

0

true

Domain

EndoE-GH18L, 2nd helical domain

EndoE-GH18L_3HB-2

1

IPR057679

57,679

Domain of unknown function DUF7919

DUF7919

Domain

421

false

This entry represents a family of uncharacterised bacterial proteins. This domain likely contains a zinc binding site.

[]

0

[ "PFAM" ]

[ "PF25535" ]

[ "DUF7919" ]

[ 421 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 411, 2, 8 ]

3

[]

0

true

Domain

Domain of unknown function DUF7919

DUF7919

6

IPR057680

57,680

Domain of unknown function DUF7920

DUF7920

Domain

331

false

This entry represents a domain of unknown function found mostly in Trypanosoma. According to structure predictions it could adopt an ATP-grasp fold which is characterised by two α-β subdomains that grasp the ATP molecules between them [ , ].

[]

0

[ "PFAM" ]

[ "PF25536" ]

[ "DUF7920" ]

[ 331 ]

1

[]

0

[]

0

[ "PUB00015342", "PUB00020972" ]

[ "7862655", "9416615" ]

[ "A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli.", "A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity." ]

[ 1995, 1997 ]

2

[]

0

null

[ "Eukaryota", "Viruses" ]

[ 327, 4 ]

2

[]

0

true

Domain

Domain of unknown function DUF7920

DUF7920

8

IPR057681

57,681

Domain of unknown function DUF7921

DUF7921

Domain

475

false

This entry represent the domain of unknown function found in Drosophila. According to structure predictions, it may adopt fybronectin type I module (FN1) fold.

[]

0

[ "PFAM" ]

[ "PF25537" ]

[ "DUF7921" ]

[ 475 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Ecdysozoa" ]

[ 475 ]

1

[ "Drosophila melanogaster" ]

[ 9 ]

1

true

Domain

Domain of unknown function DUF7921

DUF7921

5

IPR057682

57,682

Domain of unknown function DUF7922

DUF7922

Domain

176

false

This domain is found in uncharacterised bacterial proteins. It is found sometimes in combination with (DUF6128) . This domains is predicted to adopt a β-sandwich with an Ig-like topology.

[]

0

[ "PFAM" ]

[ "PF25538" ]

[ "DUF7922" ]

[ 176 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "human gut metagenome" ]

[ 175, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF7922

DUF7922

2

IPR057683

57,683

Domain of unknown function DUF7923

DUF7923

Domain

3,705

false

This domain is found in uncharacterised fungal proteins. It has detectable similarity to known PIN domains, in particular to NYN domain, and it is predicted to adopt a similar structure.

[]

0

[ "PFAM" ]

[ "PF25540" ]

[ "DUF7923" ]

[ 3705 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3705 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF7923

DUF7923

8

IPR057684

57,684

Domain of unknown function DUF7924

DUF7924

Domain

3,564

false

This entry represents a domain found in uncharacterised fungal proteins. It has a remote similarity to members of the PD-(D/E)XK nuclease superfamily and it is likely to adopt similar structure with a conserved active site architecture.

[]

0

[ "PFAM" ]

[ "PF25545" ]

[ "DUF7924" ]

[ 3564 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3564 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF7924

DUF7924

1

IPR057685

57,685

Domain of unknown function DUF7925

DUF7925

Domain

119

false

This domain is found in uncharacterised proteins predominantly from cyanobacteria. It is predicted to fold into a β-sandwich. Some members are likely to contain an isopeptide bond.

[]

0

[ "PFAM" ]

[ "PF25546" ]

[ "DUF7925" ]

[ 119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 119 ]

1

[]

0

true

Domain

Domain of unknown function DUF7925

DUF7925

7

IPR057686

57,686

Domain of unknown function DUF7926

DUF7926

Domain

151

false

This domain is found in uncharacterised bacterial proteins mainly from Actinomycetes. It is predicted to fold into a β-sandwich with topological similarity to domains members of the adhesin superfamily. Most members contain conserved lysine aspartate and asparagine residues that are likely to form an isopeptide bond. T...

[]

0

[ "PFAM" ]

[ "PF25548" ]

[ "DUF7926" ]

[ 151 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 151 ]

1

[]

0

true

Domain

Domain of unknown function DUF7926

DUF7926

1

IPR057687

57,687

Domain of unknown function DUF7927

DUF7927

Domain

954

false

This domain of unknown function is found in multiple copies in a number of bacterial proteins. It is closely related to domains represented by DUF11 ( ). Similarly to DUF11, this domain contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that it may co...

[]

0

[ "PFAM" ]

[ "PF25549" ]

[ "DUF7927" ]

[ 954 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 954 ]

1

[]

0

true

Domain

Domain of unknown function DUF7927

DUF7927

2

IPR057688

57,688

Domain of unknown function DUF7928

DUF7928

Domain

2,699

false

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into an α/β structure with topological similarity to AraD-like domains.

[]

0

[ "PFAM" ]

[ "PF25550" ]

[ "DUF7928" ]

[ 2699 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 2699 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Domain

Domain of unknown function DUF7928

DUF7928

6

IPR057689

57,689

Domain of unknown function DUF7929

DUF7929

Domain

77

false

This domain is found in a very small group of proteins mainly from Phyllobacteriaceae. It is predicted to fold into a β-sandwich with topological similarity to domains members of the adhesin superfamily. Members contain conserved lysine, aspartate and asparagine residues that are likely to form an isopeptide bond.

[]

0

[ "PFAM" ]

[ "PF25551" ]

[ "DUF7929" ]

[ 77 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Phyllobacteriaceae", "hydrothermal vent metagenome" ]

[ 76, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF7929

DUF7929

6

IPR057690

57,690

Domain of unknown function DUF7930

DUF7930

Domain

64

false

This entry represents a C-terminal OB-fold domain found in nematode proteins that generally contain 3 OB-like domains.

[]

0

[ "PFAM" ]

[ "PF25558" ]

[ "DUF7930" ]

[ 64 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 64 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF7930

DUF7930

2

IPR057691

57,691

Domain of unknown function DUF7931

DUF7931

Domain

1,235

false

This entry represents a domain of unknown function mostly found in bacteria. According to structure predictions it might adopt a phospholipase D/nuclease fold. Whilst the typical phospholipase D motif HxK(x)4D(x)6GSxN is not strictly conserved the overall fold suggests a potential distant evolutionary relationship to t...

[]

0

[ "PFAM" ]

[ "PF25559" ]

[ "DUF7931" ]

[ 1235 ]

1

[]

0

[]

0

[ "PUB00024729", "PUB00152066", "PUB00160607" ]

[ "10873862", "25429979", "20854710" ]

[ "The first crystal structure of a phospholipase D.", "Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.", "Nucleases: diversity of structure, function and mechanism." ]

[ 2000, 2014, 2011 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctnks32", "unclassified sequences" ]

[ 1193, 3, 1, 38 ]

4

[]

0

true

Domain

Domain of unknown function DUF7931

DUF7931

3

IPR057692

57,692

Domain of unknown function DUF7932

DUF7932

Domain

386

false

This entry describes a domain of unknown function located at the N-terminal of proteins mostly found in fungi. According to structure predictions it might adopt an immunoglobulin, fibronectin type III fold. It is formed of two antiparallel β-sheets stacked against each other, forming a β-sandwich [ ].

[]

0

[ "PFAM" ]

[ "PF25560" ]

[ "DUF7932" ]

[ 386 ]

1

[]

0

[]

0

[ "PUB00158558" ]

[ "20176268" ]

[ "Structure and function of immunoglobulins." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati", "Terrestrivirus sp." ]

[ 366, 19, 1 ]

3

[]

0

true

Domain

Domain of unknown function DUF7932

DUF7932

6

IPR057693

57,693

Domain of unknown function DUF7933

DUF7933

Domain

781

false

This domain of unknown function is found in multiple copies in a number of bacterial proteins. It is closely related to domains represented by DUF11 ( ). Some members, similarly to DUF11, contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that they ma...

[]

0

[ "PFAM" ]

[ "PF25564" ]

[ "DUF7933" ]

[ 781 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 780, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF7933

DUF7933

6

IPR057694

57,694

Protein of unknown function DUF7934

DUF7934

Family

12

false

This entry represents a family of uncharacterised proteins found in Bacillota species. From the genomic context, it is likely to be a phage-derived protein. It contains a helical domain composed of segments from the N-terminal and C-terminal connected by a coiled-coil region.

[]

0

[ "PFAM" ]

[ "PF25588" ]

[ "DUF7934" ]

[ 12 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Podoviridae sp. ctxJ29" ]

[ 11, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF7934

DUF7934

6

IPR057695

57,695

Protein of unknown function DUF7935

DUF7935

Family

1,811

false

This entry represents an uncharacterised protein family. Structure prediction suggests that these proteins form a membrane bound octameric complex. The N terminus of the protein contains an transmembrane α helix and the rest of the protein adopts a four helical bundle domain. This family is often found associated with ...

[]

0

[ "PFAM" ]

[ "PF25589" ]

[ "DUF7935" ]

[ 1811 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Daphnia pulex", "ecological metagenomes" ]

[ 1796, 1, 14 ]

3

[]

0

true

Family

Protein of unknown function DUF7935

DUF7935

1

IPR057697

57,697

Domain of unknown function DUF7937

DUF7937

Domain

474

false

This entry represents a family of uncharacterised membrane proteins found in Actinomycetes. These proteins contain 12 putative transmembrane helices.

[]

0

[ "PFAM" ]

[ "PF25592" ]

[ "DUF7937" ]

[ 474 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ganoderma sinense ZZ0214-1", "freshwater metagenome" ]

[ 472, 1, 1 ]

3

[]

0

true

Domain

Domain of unknown function DUF7937

DUF7937

8

IPR057698

57,698

Phage family of unknown function (DUF7938)

DUF7938

Family

9

false

This entry found in a small number of phage is uncharacterised. There is some evidence form AlphaFold 3 prediction that these proteins may form homodimers.

[]

0

[ "PFAM" ]

[ "PF25604" ]

[ "DUF7938" ]

[ 9 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Azeredovirinae", "Staphylococcus aureus" ]

[ 7, 2 ]

2

[]

0

true

Family

Phage family of unknown function (DUF7938)

DUF7938

8

IPR057700

57,700

Protein of unknown function DUF7940

DUF7940

Family

1,039

false

This family contains a set of uncharacterised bacterial and phage proteins that are annotated as putative holins.

[]

0

[ "PFAM" ]

[ "PF25612" ]

[ "DUF7940" ]

[ 1039 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Phytophthora nicotianae CJ01A1", "Pseudomonadati", "Viruses", "organismal metagenomes" ]

[ 1, 872, 161, 5 ]

4

[]

0

true

Family

Protein of unknown function DUF7940

DUF7940

4

IPR057701

57,701

Protein of unknown function DUF7941

DUF7941

Family

388

false

This entry represents an uncharacterised family of phage proteins from Uroviricota. These proteins are about 300 amino acids in length. They may represent phage structural proteins. This entry also includes some uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF25613" ]

[ "DUF7941" ]

[ 388 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ricinus communis", "Viruses" ]

[ 73, 1, 314 ]

3

[]

0

true

Family

Protein of unknown function DUF7941

DUF7941

4