interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR057702 | 57,702 | Protein of unknown function DUF7942 | DUF7942 | Family | 669 | false | false | This family of uncharacterised bacterial proteins is found mainly in Actinomycetes. Members of this family are predicted to contain three transmembrane helices. A member of this family, SCO4225, is a putative integral membrane protein found in Streptomyces coelicolor, . The gene encoding SCO4225 is part of a cluster of... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF046119",
"PF25637"
] | [
"memb_SCO4225",
"DUF7942"
] | [
629,
667
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159414",
"PUB00159567"
] | [
"30530707",
"22466952"
] | [
"Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in <i>Streptomyces coelicolor</i>.",
"Transcriptional and preliminary functional analysis of the six genes located in divergence of phoR/phoP in Streptomyces lividans."
] | [
2019,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenome"
] | [
668,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF7942 | Protein of unknown function DUF7942 | DUF7942 | 8 |
IPR057703 | 57,703 | Domain of unknown function DUF7943 | DUF7943 | Domain | 739 | false | false | This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an alpha- helical bundle. This domain is found in the hypothetical protein ESA_00282 from Cronobacter sakazakii that plays a significant role in biofilm formation and bacterial adhesion. This protein contributes to the adhesion of ... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF046012",
"PF25639"
] | [
"adhes_ESA_00282",
"DUF7943"
] | [
737,
739
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159768",
"PUB00159769"
] | [
"16980469",
"20118366"
] | [
"Uncovering a large set of genes that affect surface motility in Salmonella enterica serovar Typhimurium.",
"Genes involved in Cronobacter sakazakii biofilm formation."
] | [
2006,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
739
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7943 | Domain of unknown function DUF7943 | DUF7943 | 1 |
IPR057704 | 57,704 | Domain of unknown function DUF7944 | DUF7944 | Domain | 426 | false | false | This domain is found in uncharacterised bacterial proteins mainly from Moraxellales. It is predicted to fold into an array of α-helices. It contains two invariant cysteine residues which are predicted to form a disulfide bond. | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047330",
"PF25642"
] | [
"MCR_0457_fam",
"DUF7944"
] | [
426,
426
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159730"
] | [
"23163337"
] | [
"Genetic requirements for Moraxella catarrhalis growth under iron-limiting conditions."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
426
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7944 | Domain of unknown function DUF7944 | DUF7944 | 5 |
IPR057705 | 57,705 | Protein of unknown function DUF7945 | DUF7945 | Family | 1,193 | false | false | This domain is found in uncharacterised bacterial proteins predominantly from Actinomycetes. It is predicted to fold into an array of α-helices. Members of this entry include REIS_1423, which was suggested to be the antitoxin for REIS_1424-like toxins. | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047838",
"PF25656"
] | [
"SCO4402_fam",
"DUF7945"
] | [
1178,
1176
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159608"
] | [
"35592653"
] | [
"Cryptic Genes for Interbacterial Antagonism Distinguish <i>Rickettsia</i> Species Infecting Blacklegged Ticks From Other <i>Rickettsia</i> Pathogens."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Stylophora pistillata"
] | [
1189,
4
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF7945 | Protein of unknown function DUF7945 | DUF7945 | 3 |
IPR057706 | 57,706 | Domain of unknown function DUF7946 | DUF7946 | Domain | 220 | false | false | This entry represents a domain of unknown function found that covers the whole length of Protein 40A from Enterobacteria phage phi80 and at the N-terminal of the small β-barrel domain in a group of uncharacterised proteobacterial and phage proteins. Its function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25678"
] | [
"DUF7946"
] | [
220
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes",
"unclassified Caudoviricetes"
] | [
212,
5,
3
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7946 | Domain of unknown function DUF7946 | DUF7946 | 5 |
IPR057708 | 57,708 | Domain of unknown function DUF7948 | DUF7948 | Domain | 1,436 | false | false | This entry represents a potential adhesive domain found at the N terminus of a variety of bacterial cell surface proteins. The structure shows a large β-sandwich fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25778"
] | [
"DUF7948"
] | [
1436
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
25,
1294,
86,
31
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7948 | Domain of unknown function DUF7948 | DUF7948 | 2 |
IPR057709 | 57,709 | Domain of unknown function DUF7949 | DUF7949 | Domain | 354 | false | false | This entry describes a domain of unknown function in putative EGF-like domain-containing proteins found in eukaryotes, mainly ameobas. According to structure predictions it adopts an EGF-like fold which contain six conserved cysteine residues. The EGF-like fold has two-stranded β-sheets followed by a loop to a short C-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25820"
] | [
"DUF7949"
] | [
354
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001555"
] | [
"3282918"
] | [
"Structure and function of epidermal growth factor-like regions in proteins."
] | [
1988
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
354
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7949 | Domain of unknown function DUF7949 | DUF7949 | 3 |
IPR057710 | 57,710 | Domain of unknown function DUF7950 | DUF7950 | Domain | 1,976 | false | false | This entry represents a domain of unknown function in a group of uncharacterised proteins mainly from plants and prokaryotes. According to structure predictions it adopts a sensor-like fold, consisting of 7 β-strands arranged in a β-barrel like fold, surrounded by a small α-helix. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25821"
] | [
"DUF7950"
] | [
1976
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1976
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
30,
9,
8
] | 3 | true | Domain | Domain of unknown function DUF7950 | Domain of unknown function DUF7950 | DUF7950 | 2 |
IPR057711 | 57,711 | Repeat of unknown function DUF7951 | DUF7951 | Repeat | 87 | false | false | This entry describes a repeat of unknown function found at the C-terminal of uncharacterised proteins mainly from animals. It displays a TPR fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25824"
] | [
"DUF7951"
] | [
87
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035836"
] | [
"15590835"
] | [
"The small-subunit processome is a ribosome assembly intermediate."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
87
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Repeat | Repeat of unknown function DUF7951 | Repeat of unknown function DUF7951 | DUF7951 | 9 |
IPR057712 | 57,712 | Domain of unknown function DUF7952 | DUF7952 | Domain | 1,760 | false | false | This entry represents a domain of unknown function found in putative SANT domain-containing proteins and uncharacterised proteins found in plants. This domain is predicted to adopt an EF-hand-like fold. The EF-hand fold is a helix-loop-helix motif that can bind calcium atoms. The EF-hand fold is usually tandemly repeat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25826"
] | [
"DUF7952"
] | [
1760
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00023098"
] | [
"8602259"
] | [
"Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1760
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
6,
13
] | 3 | true | Domain | Domain of unknown function DUF7952 | Domain of unknown function DUF7952 | DUF7952 | 6 |
IPR057713 | 57,713 | Domain of unknown function DUF7953 | DUF7953 | Domain | 846 | false | false | The domain described by this entry is located towards the N-terminal in putative transmembrane and uncharacterised proteins found in plants. It is predicted to adopt a C2 fold. C2 domains are membrane-binding modules that share a common overall fold: a single compact greek-key motif organised as an eight-stranded anti-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25829"
] | [
"DUF7953"
] | [
846
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160608"
] | [
"24745792"
] | [
"Membrane structure and function: relevance of lipid and protein structures in cellular physiology, pathology and therapy."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
846
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
3,
8
] | 3 | true | Domain | Domain of unknown function DUF7953 | Domain of unknown function DUF7953 | DUF7953 | 9 |
IPR057714 | 57,714 | Nischarin, C-terminal PH domain | PH_NISCH_C | Domain | 1,418 | false | false | This domain is found at the C-terminal end of human Nischarin and related animal proteins. Nischarin functions as a molecular scaffold, interacting with various protein partners and playing important roles in cell migration, cytoskeletal organisation, and tumour suppression [ ]. Nischarin expression is often reduced in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25625"
] | [
"PH_NISCH_C"
] | [
1418
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013149",
"R-HSA-9696264",
"R-HSA-9696270",
"R-MMU-9013149",
"R-MMU-9696264",
"R-MMU-9696270",
"R-RNO-9013149",
"R-RNO-9696264",
"R-RNO-9696270"
] | [
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOME:R-MMU-9013149",
"REACTOME:R-MMU-9696264",
"REACTOME:R-MMU-9696270",
"REACTOME:R-RNO-9013149",
"REACTOME:R-RNO-9696264",
"REACTOME:R-RNO-9696270"
] | 9 | [] | 0 | [
"PUB00160660",
"PUB00160661"
] | [
"28842496",
"38781180"
] | [
"Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.",
"Analysis of the nischarin expression across human tumor types reveals its context-dependent role and a potential as a target for drug repurposing in oncology."
] | [
2017,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1418
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
5,
7
] | 4 | true | Domain | Nischarin, C-terminal PH domain | Nischarin, C-terminal PH domain | PH_NISCH_C | 3 |
IPR057715 | 57,715 | Membrane protein YohP-like | YohP-like | Family | 384 | false | false | This family represents the membrane protein YohP from E. coli and related sequences from proteobacteria. YohP is a 27-amino-acid-long protein located in the inner membrane of E. coli [ ]. YohP is recognised by the signal recognition particle (SRP). In contrast to the canonical cotranslational recognition by SRP, SRP wa... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF011345",
"PF25659"
] | [
"PRK14762.1",
"YohP"
] | [
307,
384
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104040",
"PUB00104946",
"PUB00104947",
"PUB00104948"
] | [
"19734316",
"19121005",
"21778229",
"32997663"
] | [
"Small stress response proteins in Escherichia coli: proteins missed by classical proteomic studies.",
"Small membrane proteins found by comparative genomics and ribosome binding site models.",
"Membrane localization of small proteins in Escherichia coli.",
"Posttranslational insertion of small membrane prote... | [
2010,
2008,
2011,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
384
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Membrane protein YohP-like | Membrane protein YohP-like | YohP-like | 9 |
IPR057720 | 57,720 | YTH1-like, RRM domain | RRM_YTH1 | Domain | 1,370 | false | false | This RRM domain is found in the YTH domain-containing family protein 1 (YTH1) from Cryphonectria parasitica and similar fungal proteins. YTH1 specifically recognises and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability and processing [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25701"
] | [
"RRM_YTH1"
] | [
1370
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160670"
] | [
"39159278"
] | [
"N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1370
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | YTH1-like, RRM domain | YTH1-like, RRM domain | RRM_YTH1 | 9 |
IPR057721 | 57,721 | BCD1, alpha/beta domain | BCD1_alpha/beta | Domain | 4,377 | false | false | This domain is found in Box C/D snoRNA protein 1 from Saccharomyces cerevisiae (BCD1), which is required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis [ ]. This domain shows an α-β configuration and is often found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25790"
] | [
"BCD1"
] | [
4377
] | 1 | [] | [] | [] | 0 | [
"6nz2",
"6thl"
] | 2 | [
"PUB00014725",
"PUB00160575"
] | [
"12837249",
"33767140"
] | [
"A panoramic view of yeast noncoding RNA processing.",
"The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity."
] | [
2003,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4377
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
1,
2,
1,
3,
1,
3,
8,
1,
1,
3
] | 12 | true | Domain | BCD1, alpha/beta domain | BCD1, alpha/beta domain | BCD1_alpha/beta | 4 |
IPR057722 | 57,722 | AsqO/PenF-like, C-terminal domain | AsqO/PenF-like_C | Domain | 831 | false | false | This domain is found at the C-terminal end of Quinolone epoxide rearrangement protein asqO from Emericella nidulans and similar fungal proteins, including Quinolone epoxide rearrangement protein penF from Penicillium thymicola. Proteins in this family are predicted to consist of two similar β-barrel domains: and this e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25581"
] | [
"AsqO_C"
] | [
831
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00082624",
"PUB00100820",
"PUB00160266",
"PUB00160736"
] | [
"25251934",
"25859931",
"30026518",
"28114276"
] | [
"Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.",
"Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.",
"Enzymatic one-step ring contraction fo... | [
2014,
2015,
2018,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
20,
810,
1
] | 3 | [] | [] | 0 | true | Domain | AsqO/PenF-like, C-terminal domain | AsqO/PenF-like, C-terminal domain | AsqO/PenF-like_C | 7 |
IPR057723 | 57,723 | Densovirus VP1 protein | AdSDV_VP1 | Family | 42 | false | false | This entry represents the structural protein VP1 of the Acheta domesticus segmented densovirus (AdSDV), the first parvovirus discovered with a bipartite genome. This structural protein forms the viral capsid, which displays T=1 icosahedral symmetry. Unlike other parvoviruses, AdSDV packages its NS and VP cassettes on s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25662"
] | [
"AdSDV_VP1"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"8er8",
"8erk",
"8eu5",
"8eu6",
"8eu7"
] | 5 | [
"PUB00160562"
] | [
"37316488"
] | [
"Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Neoptera",
"Parvoviridae"
] | [
12,
30
] | 2 | [] | [] | 0 | true | Family | Densovirus VP1 protein | Densovirus VP1 protein | AdSDV_VP1 | 1 |
IPR057724 | 57,724 | Tectonic-1-3, N-terminal domain | TCTN1-3_N | Domain | 3,405 | false | false | This is domain is found N-terminal in tectonic proteins (TCTN1-3) It contains a number of conserved cysteine residues predicted to form disulfide bonds. Although function of this domain is currently unknown, studies on TCTN2 suggest that it is indispensable for its functions [ , ]. TCTN1, TCTN2, and TCTN3 are members o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25752"
] | [
"DUF1619_N"
] | [
3405
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [
"PUB00069722",
"PUB00097826",
"PUB00097827",
"PUB00160606"
] | [
"22179047",
"29866362",
"27770015",
"37704658"
] | [
"A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.",
"Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.",
"Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.",
"The tectonic com... | [
2012,
2018,
2017,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3405
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
27,
6,
10
] | 5 | true | Domain | Tectonic-1-3, N-terminal domain | Tectonic-1-3, N-terminal domain | TCTN1-3_N | 2 |
IPR057725 | 57,725 | Ams2/SPT21, N-terminal domain | Ams2-SPT21_N | Domain | 1,402 | false | false | This entry describes the N-terminal domain found in CENP-A multicopy suppressor protein 2 (Ams2) and SPT21 proteins found in Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively. Ams2 is required for proper chromosome segregation via regulation of CENP-A localisation to the centromere [ ]. SPT21 is requi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25823"
] | [
"Ams2-SPT21_N"
] | [
1402
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092936",
"PUB00092937",
"PUB00160563"
] | [
"12535531",
"21057056",
"27901072"
] | [
"A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.",
"Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae.",
"Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription."
] | [
2003,
2011,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1402
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Ams2/SPT21, N-terminal domain | Ams2/SPT21, N-terminal domain | Ams2-SPT21_N | 5 |
IPR057726 | 57,726 | Tsg, C-terminal domain | Tsg_C | Domain | 1,672 | false | false | This entry represents the C-terminal domain of Tsg. This domain contains a mixed α/β fold. It is stabilised by disulfide bonds. It directly binds the C-terminal region of Chordin, a BMP antagonist, to stabilise the inhibitory complex that blocks BMP-receptor interactions [ ]. Twisted gastrulation (Tsg) was identified i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04668"
] | [
"Tsg"
] | [
1672
] | 1 | [] | [] | [] | 0 | [
"8bwa",
"8bwd",
"8bwi"
] | 3 | [
"PUB00008529",
"PUB00008530",
"PUB00160740"
] | [
"7958834",
"11260716",
"26829466"
] | [
"Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.",
"Twisted gastrulation is a conserved extracellular BMP antagonist.",
"Structural characterization of twisted gastrulation provides insights into opposi... | [
1994,
2001,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1672
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
2,
2,
2
] | 5 | true | Domain | Tsg, C-terminal domain | Tsg, C-terminal domain | Tsg_C | 9 |
IPR057727 | 57,727 | WCX domain | WCX_dom | Domain | 36,168 | false | false | This domain is found in the PafB and PafC heteromeric regulators that act as transcriptional activators and belong to the large bacterial family of WYL domain- containing proteins [ ]. In these proteins, WCX domain (WYL C-terminal extension) is found next to the WYL domain. WCX domain is involved in heterodimer formati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25583"
] | [
"WCX"
] | [
36168
] | 1 | [] | [] | [] | 0 | [
"6sj9",
"7p5x",
"7tzv",
"7u02",
"8tp8",
"8tpk",
"9cu3",
"9fnd",
"9fne"
] | 9 | [
"PUB00068192",
"PUB00160946"
] | [
"17277063",
"39919186"
] | [
"Characterization of the proteasome accessory factor (paf) operon in Mycobacterium tuberculosis.",
"Single-stranded DNA binding to the transcription factor PafBC triggers the mycobacterial DNA damage response."
] | [
2007,
2025
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermococcus barossii",
"unclassified sequences"
] | [
35612,
13,
1,
542
] | 4 | [] | [] | 0 | true | Domain | WCX domain | WCX domain | WCX_dom | 4 |
IPR057728 | 57,728 | Anti-CRISPR protein AcrF2 | AcrF2 | Family | 7 | false | false | AcrF2 is involved in helping bacteriophages evade the CRISPR/Cas type I-F immune system in bacteria. This function allows the phage to bypass the bacterial defence mechanism, which typically targets and degrades foreign genetic material. By inhibiting the CRISPR/Cas system, the Anti-CRISPR protein 30 family plays a cru... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF25704",
"cd22280"
] | [
"AcrF2",
"AcrIF2"
] | [
7,
7
] | 2 | [] | [] | [] | 0 | [
"5uz9",
"5yhr",
"6b47",
"8dfs"
] | 4 | [
"PUB00105454",
"PUB00106898",
"PUB00106902",
"PUB00146745",
"PUB00146746",
"PUB00146747",
"PUB00146748",
"PUB00146749",
"PUB00146750",
"PUB00146751",
"PUB00146752",
"PUB00146901",
"PUB00146902",
"PUB00147200",
"PUB00147226"
] | [
"30578665",
"36805026",
"28985564",
"29554913",
"31392299",
"31021234",
"32203383",
"31730297",
"31021272",
"32286628",
"28749735",
"28574055",
"28340349",
"29348170",
"23242138"
] | [
"New paradigm of functional regulation by DNA mimic proteins: Recent updates.",
"Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.",
"Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.",
"Structural insights into the inactivation of C... | [
2019,
2023,
2017,
2018,
2019,
2019,
2020,
2020,
2018,
2020,
2017,
2017,
2017,
2018,
2013
] | 15 | [] | [] | 0 | 0 | null | [
"Pseudoxanthomonas winnipegensis",
"Viruses"
] | [
1,
6
] | 2 | [] | [] | 0 | true | Family | Anti-CRISPR protein AcrF2 | Anti-CRISPR protein AcrF2 | AcrF2 | 8 |
IPR057729 | 57,729 | Anti-CRISPR protein F31 | AcrF31 | Family | 9 | false | false | This entry represents anti-CRISPR protein AcrF31, a fusion of AcrIE4 and AcrIF7 domains that inhibits both type I-E and type I-F CRISPR-Cas systems [ , ]. The N-terminal domain adopts a novel α-helical fold and targets the PAM (protospacer adjacent motif) interaction site of the type I-E Cas8e subunit. The C-terminal d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25703"
] | [
"AcrF31"
] | [
9
] | 1 | [] | [] | [] | 0 | [
"7vzm"
] | 1 | [
"PUB00148026",
"PUB00160561",
"PUB00160746"
] | [
"24736222",
"35166843",
"26416740"
] | [
"A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.",
"The structure of AcrIE4-F7 reveals a common strategy for dual CRISPR inhibition by targeting PAM recognition sites.",
"Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins."
] | [
2014,
2022,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonas citronellolis",
"Viruses",
"viral metagenome"
] | [
1,
6,
2
] | 3 | [] | [] | 0 | true | Family | Anti-CRISPR protein F31 | Anti-CRISPR protein F31 | AcrF31 | 2 |
IPR057730 | 57,730 | Anti-CRISPR protein AcrF8 | AcrF8 | Family | 4 | false | false | This entry represents AcrF8, an anti-CRISPR protein that inhibits the type I-F CRISPR-Cas system. AcrF8 is a 92-residue protein that occupies the cavity surrounded by Cas5f, Cas7.4-7.6f, and Cas8f subunits in the Csy complex. AcrF8 forms unique interactions with crRNA, making it distinct from other anti-CRISPR proteins... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25699"
] | [
"AcrF8"
] | [
4
] | 1 | [] | [] | [] | 0 | [
"6vqw"
] | 1 | [
"PUB00106900",
"PUB00160947"
] | [
"32170016",
"31474367"
] | [
"Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM.",
"Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription."
] | [
2020,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Delftia tsuruhatensis"
] | [
3,
1
] | 2 | [] | [] | 0 | true | Family | Anti-CRISPR protein AcrF8 | Anti-CRISPR protein AcrF8 | AcrF8 | 6 |
IPR057731 | 57,731 | STIL, N-terminal domain | STIL_N | Domain | 1,673 | false | false | This entry represents the N-terminal domain in human SCL/TAL1 interrupting locus (STIL) protein and homologues. SIL (also called STIL/TAL1 interrupting locus) is an immediate-early gene that is essential for embryonic development and is implicated in T-cell leukemia-associated translocations [ , ]. Sil protein is neces... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15253"
] | [
"STIL_N"
] | [
1673
] | 1 | [] | [] | [] | 0 | [
"5oi9",
"5oid"
] | 2 | [
"PUB00053803",
"PUB00060062",
"PUB00060063",
"PUB00060064",
"PUB00060066",
"PUB00060086"
] | [
"12006978",
"17576815",
"11668681",
"19215732",
"8825637",
"16024801"
] | [
"Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.",
"The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.",
"Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.",
"Mutations in STIL, ... | [
2002,
2007,
2001,
2009,
1995,
2005
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1673
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
8,
1
] | 4 | true | Domain | STIL, N-terminal domain | STIL, N-terminal domain | STIL_N | 8 |
IPR057732 | 57,732 | UBE2O, N-terminal SH3-A domain | SH3-A_UBE2O | Domain | 1,114 | false | false | This domain is found at the N-terminal in the human E3-independent E2 ubiquitin-conjugating enzyme (UBE2O) and related proteins. The domain represented by this entry folds into an open β-barrel with a typical SH3-like topology. This domain contains a large unstructured region with a high content of glycine residues. UB... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23048"
] | [
"SH3-A_UBE2O"
] | [
1114
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [
"7un3",
"7un6"
] | 2 | [
"PUB00155835",
"PUB00155836",
"PUB00155837"
] | [
"23455153",
"24703950",
"35915257"
] | [
"Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.",
"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.",
"Mechanism of client selection by the protein quality-control factor UB... | [
2013,
2014,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Cohnella fermenti",
"Eukaryota"
] | [
1,
1113
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
1,
3,
6
] | 6 | true | Domain | UBE2O, N-terminal SH3-A domain | UBE2O, N-terminal SH3-A domain | SH3-A_UBE2O | 3 |
IPR057733 | 57,733 | UBE2O-like, SH3-B domain | UBE2O-like_SH3-B | Domain | 3,851 | false | false | This domain is found in the human E3-independent E2 ubiquitin-conjugating enzyme (UBE2O) and related eukaryotic proteins. The domain represented by this entry folds into an open β-barrel with typical SH3 topology. It precedes the ubiquitin-binding SH3-C domain ( ). UBE2O is involved in the monoubiquitination of diverse... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23043"
] | [
"SH3-B_UBE2O"
] | [
3851
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [
"7un3",
"7un6",
"7yw1"
] | 3 | [
"PUB00155835",
"PUB00155836",
"PUB00155837",
"PUB00160908"
] | [
"23455153",
"24703950",
"35915257",
"24474629"
] | [
"Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.",
"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.",
"Mechanism of client selection by the protein quality-control factor UB... | [
2013,
2014,
2022,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ruthgordonvirinae"
] | [
3848,
3
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
2,
2,
1,
10,
3,
16
] | 8 | true | Domain | UBE2O-like, SH3-B domain | UBE2O-like, SH3-B domain | UBE2O-like_SH3-B | 3 |
IPR057734 | 57,734 | UBE2O-like, SH3-C domain | UBE2O-like_SH3-C | Domain | 3,162 | false | false | This domain is found in the human E3-independent E2 ubiquitin-conjugating enzyme UBE2O and related proteins. The domain represented by this entry folds into an open β-barrel with typical SH3 topology. It binds ubiquitin via a unique, distinct interface and plays a key role in the UBE2O target selection [ ]. UBE2O is in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23044"
] | [
"SH3-C_UBE2O"
] | [
3162
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [
"7un3",
"7un6"
] | 2 | [
"PUB00155835",
"PUB00155836",
"PUB00155837",
"PUB00160908"
] | [
"23455153",
"24703950",
"35915257",
"24474629"
] | [
"Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.",
"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.",
"Mechanism of client selection by the protein quality-control factor UB... | [
2013,
2014,
2022,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"hydrothermal vent metagenome",
"uncultured Caudovirales phage"
] | [
3160,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
2,
2,
1,
4,
3,
16
] | 8 | true | Domain | UBE2O-like, SH3-C domain | UBE2O-like, SH3-C domain | UBE2O-like_SH3-C | 5 |
IPR057735 | 57,735 | UBE2O-like, tandem tSH3-B domain | UBE2O-like_tSH3-B | Domain | 3,758 | false | false | This domain is found in the human E3-independent E2 ubiquitin-conjugating enzyme UBE2O and related proteins. The domain represented by this entry folds into two tandem, intertwined β-barrels, each of which has a typical SH3 topology [ ]. This tandem SH3-like domain is involved in binding to NAP1L1, one of the major reg... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23046"
] | [
"tSH3-B_UBE2O"
] | [
3758
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [
"7un3",
"7un6"
] | 2 | [
"PUB00155835",
"PUB00155836",
"PUB00155837",
"PUB00160908"
] | [
"23455153",
"24703950",
"35915257",
"24474629"
] | [
"Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.",
"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.",
"Mechanism of client selection by the protein quality-control factor UB... | [
2013,
2014,
2022,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3758
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
2,
2,
1,
9,
3,
20
] | 8 | true | Domain | UBE2O-like, tandem tSH3-B domain | UBE2O-like, tandem tSH3-B domain | UBE2O-like_tSH3-B | 6 |
IPR057736 | 57,736 | PseI/NeuA/NeuB, SAF domain | SAF_PseI/NeuA/NeuB | Domain | 9,801 | false | false | This entry represents the SAF domain at the C-terminal in acid synthases such as PseI, NeuA, NeuB and related proteins. NeuB is the prokaryotic N-acetylneuraminic acid synthase. It catalyses the direct formation of N-acetylneuraminic acid (Neu5Ac), the most common sialic acid, by condensation of phosphoenolpyruvate (PE... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd11615"
] | [
"SAF_NeuB_like"
] | [
9801
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1",
"R-DME-4085001",
"R-HSA-4085001",
"R-MMU-4085001"
] | [
"EC:2.5.1",
"REACTOME:R-DME-4085001",
"REACTOME:R-HSA-4085001",
"REACTOME:R-MMU-4085001"
] | 4 | [
"1vli",
"1wvo",
"1xuu",
"1xuz",
"2wqp",
"4ipi",
"4ipj",
"6ppw",
"6ppx",
"6ppy",
"6ppz",
"8h2c"
] | 12 | [
"PUB00007383",
"PUB00017194",
"PUB00032527",
"PUB00038161",
"PUB00070658",
"PUB00070659"
] | [
"10873658",
"15146494",
"15516336",
"16597820",
"10749855",
"15888312"
] | [
"Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.",
"The emergence of catalytic and structural diversity within the beta-clip fold.",
"Structural and mechanistic analysis of sialic acid synt... | [
2000,
2004,
2005,
2006,
2000,
2005
] | 6 | [
"IPR006190"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
179,
8176,
1196,
2,
248
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
2,
1,
4
] | 5 | true | Domain | PseI/NeuA/NeuB, SAF domain | PseI/NeuA/NeuB, SAF domain | SAF_PseI/NeuA/NeuB | 9 |
IPR057737 | 57,737 | Phenyloxazoline synthase MbtB-like, condensation domain | Condensation_MtbB-like | Domain | 5,530 | false | false | This entry represents the condesantion domain found in Phenyloxazoline synthase MbtB, Pyochelin synthetase PchF/E and similar bacterial proteins. This domain is a pseudo-dimer of two lobes, the N-terminal lobe (N-lobe) and the C-terminal lobe (C-lobe), each of them consisting of one large central β-sheet, flanked by pr... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd19535"
] | [
"Cyc_NRPS"
] | [
5530
] | 1 | [] | [] | [] | 0 | [
"5t3e",
"5t7z",
"5t81",
"6lta",
"6ltb",
"6ltc",
"6ltd",
"7emy",
"7en1",
"7en2",
"7jtj",
"7jua",
"7ly4",
"7ly7",
"7ry6"
] | 15 | [
"PUB00007135",
"PUB00013827",
"PUB00033383",
"PUB00095150",
"PUB00107540",
"PUB00107541",
"PUB00107542",
"PUB00107543",
"PUB00107544",
"PUB00120327",
"PUB00160766",
"PUB00160767"
] | [
"9712910",
"10021423",
"9427658",
"28526268",
"27994138",
"27791103",
"17506888",
"12564937",
"26429504",
"10655517",
"38138601",
"9846750"
] | [
"Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain.",
"How do peptide synthetases generate structural diversity?",
"The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.... | [
1998,
1999,
1997,
2017,
2017,
2016,
2007,
2003,
2016,
2000,
2023,
1998
] | 12 | [
"IPR001242"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5402,
109,
19
] | 3 | [] | [] | 0 | true | Domain | Phenyloxazoline synthase MbtB-like, condensation domain | Phenyloxazoline synthase MbtB-like, condensation domain | Condensation_MtbB-like | 4 |
IPR057739 | 57,739 | Glycoside hydrolase family 29, N-terminal | Glyco_hydro_29_N | Domain | 24,634 | false | false | This entry represents the N-terminal domain of O-Glycosyl hydrolases family 29 proteins. O-Glycosyl hydrolases family 29 ( ) encompasses alpha-L-fucosidases ( ) [ ], which is a lysosomal enzyme responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01120"
] | [
"Alpha_L_fucos"
] | [
24634
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"3.2.1.51",
"PWY-6807",
"R-BTA-6798695",
"R-BTA-975578",
"R-CEL-381426",
"R-CEL-6798695",
"R-CEL-8957275",
"R-CEL-975578",
"R-DDI-6798695",
"R-DDI-975578",
"R-DME-381426",
"R-DME-6798695",
"R-DME-8957275",
"R-DME-975578",
"R-HSA-381426",
"R-HSA-6798695",
"R-HSA-8957275",
"R-HSA-975... | [
"EC:3.2.1.51",
"METACYC:PWY-6807",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-975578",
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-8957275",
"REACTOME:R-CEL-975578",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-975578",
"REACTOME:R-DME-381426",
"REACTOME:R-DME-6798695",
"R... | 26 | [
"1hl8",
"1hl9",
"1odu",
"2wsp",
"2wvs",
"2wvt",
"2wvu",
"2wvv",
"2xib",
"2xii",
"2zwy",
"2zwz",
"2zx5",
"2zx6",
"2zx7",
"2zx8",
"2zx9",
"2zxa",
"2zxb",
"2zxd",
"3eyp",
"3gza",
"3mo4",
"3ues",
"3uet",
"4j27",
"4j28",
"4jfs",
"4jft",
"4jfu",
"4jfv",
"4jfw"... | 89 | [
"PUB00000482",
"PUB00004870",
"PUB00005266",
"PUB00021761",
"PUB00043486",
"PUB00043487"
] | [
"2482732",
"7624375",
"8535779",
"14715651",
"18556148",
"18522672"
] | [
"Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase.",
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Crystal structure of Thermotoga maritima alpha-L-fucosidas... | [
1989,
1995,
1995,
2004,
2008,
2008
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
81,
17431,
6764,
5,
353
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
4,
1,
5,
5,
5,
7,
11
] | 9 | true | Domain | Glycoside hydrolase family 29, N-terminal | Glycoside hydrolase family 29, N-terminal | Glyco_hydro_29_N | 6 |
IPR057741 | 57,741 | Serine-protein kinase YeaG | YeaG | Family | 4,950 | false | false | This entry represents YeaG and similar proteins mainly from proteobacteria. Serine/threonine kinase YeaG plays a role in bacterial adaptation to sustained nitrogen starvation [ ]. It may function by indirectly repressing the transcription of two toxin-antitoxin modules, MqsR/MqsA and DinJ/YafQ, which in turn positively... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF011999"
] | [
"PRK15455.1"
] | [
4950
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [
"PUB00160792",
"PUB00160793",
"PUB00160794"
] | [
"18276156",
"26621053",
"33889145"
] | [
"Cloning, expression, purification and characterization of the stress kinase YeaG from Escherichia coli.",
"Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG.",
"Phosphoproteome Study of <i>Escherichia coli</i> Devoid of Ser/Thr Kinase YeaG ... | [
2008,
2015,
2021
] | 3 | [
"IPR016230"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"metagenomes",
"uncultured marine phage"
] | [
4917,
4,
28,
1
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Serine-protein kinase YeaG | Serine-protein kinase YeaG | YeaG | 5 |
IPR057742 | 57,742 | Speedy E | Speedy_E | Family | 539 | false | false | This entry represents Speedy E proteins from mammals. Speedy (Spy1, also known as RINGO A) is a cell cycle regulatory protein which binds and activates CDK1 and CDK2 [ ], protein kinases that allows progression through G1/S phase and further replication events. Spy1 activates CDK2 inducing a conformational change of th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31156"
] | [
""
] | [
539
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054157",
"PUB00099648",
"PUB00099649"
] | [
"17671428",
"28666995",
"12972555"
] | [
"Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.",
"Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.",
"Spy1 interacts with p27Kip1 to allow G1/S progression."
] | [
2007,
2017,
2003
] | 3 | [
"IPR020984"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
539
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
30,
6,
7
] | 3 | true | Family | Speedy E | Speedy E | Speedy_E | 7 |
IPR057743 | 57,743 | VAL1-3, N-terminal zinc finger domain | Zfn_VAL1-3_N | Domain | 2,419 | false | false | This zinc finger is found at the N-terminal end of B3 domain-containing transcription repressor VAL1-3 from Arabidopsis thaliana, its homologues from rice Os07g0563300 and Os07g0679700 and similar plant proteins. VAL1/2 are transcriptional repressors of gene expression involved in embryonic pathways that play an essent... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25813"
] | [
"zf_VAL1_N"
] | [
2419
] | 1 | [] | [] | [] | 0 | [
"5yug",
"5yuh",
"5z28"
] | 3 | [
"PUB00160811",
"PUB00160812",
"PUB00160813"
] | [
"15894743",
"17158584",
"17267611"
] | [
"Analysis of a sugar response mutant of Arabidopsis identified a novel B3 domain protein that functions as an active transcriptional repressor.",
"Repression of the LEAFY COTYLEDON 1/B3 regulatory network in plant embryo development by VP1/ABSCISIC ACID INSENSITIVE 3-LIKE B3 genes.",
"Two B3 domain transcriptio... | [
2005,
2007,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2419
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
4,
42
] | 3 | true | Domain | VAL1-3, N-terminal zinc finger domain | VAL1-3, N-terminal zinc finger domain | Zfn_VAL1-3_N | 3 |
IPR057744 | 57,744 | Ochratoxinase-like | OTAase-like | Domain | 15,694 | false | false | This entry describes Ochratoxinase and uncharacterised proteins from bacteria and fungi which are likely Metallo-dependent hydrolases. Proteins represented by this entry have a conserved metal binding site, involving four histidines and one aspartic acid residue. Ochratoxinase is a carboxypeptidase that catalyses the r... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd01299"
] | [
"Met_dep_hydrolase_A"
] | [
15694
] | 1 | [] | [] | [] | 0 | [
"2p9b",
"2qs8",
"3be7",
"3dug",
"3feq",
"3mkv",
"3mtw",
"3n2c",
"4c5y",
"4c5z",
"4c60",
"4c65",
"8ihq",
"8ihr",
"8ihs",
"8j85",
"8yag",
"8yak"
] | 18 | [
"PUB00004994",
"PUB00160814",
"PUB00160815"
] | [
"9144792",
"24947135",
"33647354"
] | [
"An evolutionary treasure: unification of a broad set of amidohydrolases related to urease.",
"Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.",
"Engineering a carboxypeptidase from Aspergillus niger M00988 by mutation to increase its ability in high Fischer rati... | [
1997,
2014,
2021
] | 3 | [
"IPR006680"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
356,
12288,
2885,
165
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
1
] | 2 | true | Domain | Ochratoxinase-like | Ochratoxinase-like | OTAase-like | 4 |
IPR057746 | 57,746 | Outer membrane channel protein CpnT-like, N-terminal domain | CpnT-like_N | Domain | 4,869 | false | false | This entry represents a domain found towards the N-terminal of the Mycobacterium tuberculosis Outer membrane channel protein CpnT ( ) and similar sequences from actinomycetes. Members of this group are related to the WXG100 superfamily. CpmT has a dual function in the uptake of nutrients and the induction of host cell ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25547"
] | [
"WXG100_2"
] | [
4869
] | 1 | [
"REACTOME"
] | [
"R-HSA-9637698"
] | [
"REACTOME:R-HSA-9637698"
] | 1 | [] | 0 | [
"PUB00082600"
] | [
"24753609"
] | [
"An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
4864,
5
] | 2 | [] | [] | 0 | true | Domain | Outer membrane channel protein CpnT-like, N-terminal domain | Outer membrane channel protein CpnT-like, N-terminal domain | CpnT-like_N | 8 |
IPR057748 | 57,748 | Nuclear factor related to kappa-B-binding protein, second winged helix domain | NFRKB_WH_2 | Domain | 2,805 | false | false | This domain is found in the human Nuclear factor related to kappa-B-binding protein (NFRKB) and related proteins from animals and plants. This domain has a significant similarity to known winged helix domains, and it is predicted to adopt a similar structure. NFRKB is a putative regulatory component of the chromatin re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25793"
] | [
"WHD_2nd_NFRKB"
] | [
2805
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5689603",
"R-HSA-5696394",
"R-MMU-5689603",
"R-MMU-5696394"
] | [
"REACTOME:R-HSA-5689603",
"REACTOME:R-HSA-5696394",
"REACTOME:R-MMU-5689603",
"REACTOME:R-MMU-5696394"
] | 4 | [] | 0 | [
"PUB00056693"
] | [
"18922472"
] | [
"Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2805
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
3,
1,
3,
3,
6
] | 8 | true | Domain | Nuclear factor related to kappa-B-binding protein, second winged helix domain | Nuclear factor related to kappa-B-binding protein, second winged helix domain | NFRKB_WH_2 | 7 |
IPR057749 | 57,749 | WDR47, cross-over region | WDR47_COR | Domain | 2,237 | false | false | This entry represents the cross-over region (COR) of the N-terminal domain of WD repeat-containing protein 47 (WDR47). The COR consists of three α-helices that intertwine to form a dimer interface and contains a non-canonical target-binding pocket. This pocket specifically recognises a basic helical motif (WBR) in Calm... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25602"
] | [
"WDR47_COR"
] | [
2237
] | 1 | [] | [] | [] | 0 | [
"7wej",
"7wek"
] | 2 | [
"PUB00090492",
"PUB00090495",
"PUB00160727",
"PUB00160817",
"PUB00160818",
"PUB00160819"
] | [
"29078390",
"22523538",
"36351391",
"32320668",
"34608154",
"39609633"
] | [
"WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.",
"Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats.",
"Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation.",
"Wdr47 ... | [
2017,
2012,
2022,
2020,
2021,
2025
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2237
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2,
2,
3
] | 5 | true | Domain | WDR47, cross-over region | WDR47, cross-over region | WDR47_COR | 5 |
IPR057750 | 57,750 | Tripartite motif-containing protein 2/3, C-terminal domain | TRIM2/3_C | Domain | 3,477 | false | false | This entry represents the C-terminal domain in human Tripartite motif-containing protein 2/3 (TRIM2/3) and similar animal proteins. It is formed by NHL repeats ( ). TRIM2 is a UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and phosphorylated BCL2L11, playing a neuroprotective role... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd14960"
] | [
"NHL_TRIM2_like"
] | [
3477
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-HSA-877300"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-HSA-877300"
] | 3 | [
"7b2r",
"7b96",
"7qrv",
"7qrw"
] | 4 | [
"PUB00122313",
"PUB00122314",
"PUB00122315",
"PUB00136281",
"PUB00160816"
] | [
"23562820",
"20796172",
"18687884",
"20352094",
"24068738"
] | [
"Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal neuropathy.",
"The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.",
"Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.",
"Degradation of postsynaptic scaffold GKAP and regu... | [
2013,
2011,
2008,
2010,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3477
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
31,
7,
9
] | 4 | true | Domain | Tripartite motif-containing protein 2/3, C-terminal domain | Tripartite motif-containing protein 2/3, C-terminal domain | TRIM2/3_C | 2 |
IPR057751 | 57,751 | Viral Fc-gamma receptor-like protein UL119-like domain | Viral_FcR_dom | Domain | 76 | false | false | This entry represents a viral domain found in Fc-gamma receptor-like protein UL119 (gp68) and similar cytomegalovirus proteins. The domain binds to the Fc part of human IgG and may be involved in interfering with host Ig-mediated immune responses [ ]. Unlike host Fc receptors, viral Fc receptors can bind to deglycosyla... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25741"
] | [
"Viral_FcR"
] | [
76
] | 1 | [
"REACTOME"
] | [
"R-HSA-9609690"
] | [
"REACTOME:R-HSA-9609690"
] | 1 | [] | 0 | [
"PUB00160726"
] | [
"18216124"
] | [
"The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Betaherpesvirinae"
] | [
76
] | 1 | [] | [] | 0 | true | Domain | Viral Fc-gamma receptor-like protein UL119-like domain | Viral Fc-gamma receptor-like protein UL119-like domain | Viral_FcR_dom | 1 |
IPR057753 | 57,753 | Cytomegalovirus US29-like | US29-like | Family | 99 | false | false | This entry represents the uncharacterised US29 protein from Human cytomegalovirus (HCMV) and similar sequences from betaherpesviruses (Cytomegalovirus). US29 is a membrane protein with two predicted transmembrane helices. The specific function of this protein remains unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25728"
] | [
"US29"
] | [
99
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cytomegalovirus"
] | [
99
] | 1 | [] | [] | 0 | true | Family | Cytomegalovirus US29-like | Cytomegalovirus US29-like | US29-like | 3 |
IPR057754 | 57,754 | Phosphatidylinositol 4-kinase beta/PIK1, catalytic domain | PI4-kinase_beta/PIK1_cat | Domain | 5,091 | false | false | This entry represents the catalytic domain in mammal Phosphatidylinositol 4-kinase beta, its yeast homologue Phosphatidylinositol 4-kinase PIK1 and similar eukaryotic sequences. Phosphatidylinositol 4-kinase (PI4-kinase) ( ) [ ] is an enzyme that acts on phosphatidylinositol (PI) in the first committed step in the prod... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd05168"
] | [
"PI4Kc_III_beta"
] | [
5091
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.67",
"PWY-6351",
"PWY-6352",
"R-DRE-1660514",
"R-HSA-1660514",
"R-MMU-1660514",
"R-RNO-1660514",
"R-SCE-1660514",
"R-SPO-1660514",
"R-XTR-1660514"
] | [
"EC:2.7.1.67",
"METACYC:PWY-6351",
"METACYC:PWY-6352",
"REACTOME:R-DRE-1660514",
"REACTOME:R-HSA-1660514",
"REACTOME:R-MMU-1660514",
"REACTOME:R-RNO-1660514",
"REACTOME:R-SCE-1660514",
"REACTOME:R-SPO-1660514",
"REACTOME:R-XTR-1660514"
] | 10 | [
"4d0l",
"4d0m",
"4wae",
"4wag",
"5c46",
"5c4g",
"5euq",
"5fbl",
"5fbq",
"5fbr",
"5fbv",
"5fbw",
"6gl3",
"8q6f",
"8q6g",
"8q6h",
"8vof"
] | 17 | [
"PUB00001254",
"PUB00014536",
"PUB00062292",
"PUB00062293",
"PUB00062294",
"PUB00112856",
"PUB00112857",
"PUB00118534",
"PUB00118535",
"PUB00118536",
"PUB00118537",
"PUB00118538",
"PUB00118539",
"PUB00118540",
"PUB00118541",
"PUB00118542",
"PUB00118543",
"PUB00118544",
"PUB001185... | [
"8194527",
"12456783",
"9405935",
"10559940",
"12749687",
"16793271",
"15979509",
"17483288",
"17088255",
"17003043",
"16912074",
"16649109",
"16365163",
"16014415",
"15691741",
"15576365",
"15574876",
"12477731",
"11950893",
"11526106",
"11277933"
] | [
"PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.",
"Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.",
"Identification and characterization of a novel human phosphatidylinositol 4-kinase.",
"ARF mediates recruitment of PtdIns-4-OH kinas... | [
1994,
2002,
1997,
1999,
2003,
2006,
2005,
2007,
2007,
2006,
2006,
2006,
2005,
2005,
2005,
2005,
2005,
2003,
2002,
2001,
2001
] | 21 | [
"IPR000403"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
5091
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
4,
3,
2,
2,
1,
2,
8,
1,
1,
7
] | 12 | true | Domain | Phosphatidylinositol 4-kinase beta/PIK1, catalytic domain | Phosphatidylinositol 4-kinase beta/PIK1, catalytic domain | PI4-kinase_beta/PIK1_cat | 7 |
IPR057755 | 57,755 | Netrin receptor UNC5A-D-like, N-terminal domain | UNC5A-D-like_N | Domain | 7,404 | false | false | This entry represents the N-terminal immunoglobulin-like (Ig-like) domain of Netrin receptor UNC5A-D and similar animal proteins. This domain is not present in mice and human UNC5C-like proteins . UNC-5 proteins are transmembrane netrin receptors that play a crucial role in axon guidance and neuronal development. Upon ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25609"
] | [
"Unc5_NetrinR_N"
] | [
7404
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-373752",
"R-CEL-418886",
"R-DME-373752",
"R-DME-418886",
"R-HSA-373752",
"R-HSA-418886",
"R-HSA-418889",
"R-MMU-373752",
"R-RNO-373752"
] | [
"REACTOME:R-CEL-373752",
"REACTOME:R-CEL-418886",
"REACTOME:R-DME-373752",
"REACTOME:R-DME-418886",
"REACTOME:R-HSA-373752",
"REACTOME:R-HSA-418886",
"REACTOME:R-HSA-418889",
"REACTOME:R-MMU-373752",
"REACTOME:R-RNO-373752"
] | 9 | [
"4v2a",
"4v2b",
"4v2c",
"5ftt",
"5ftu",
"6ool",
"7za1",
"7za2",
"7za3",
"8edc",
"8edi"
] | 11 | [
"PUB00038108",
"PUB00087893",
"PUB00099094",
"PUB00160820",
"PUB00160821",
"PUB00160822"
] | [
"17139086",
"18266062",
"28483977",
"11387206",
"11454756",
"24691657"
] | [
"Structure of the UNC5H2 death domain.",
"Netrins and UNC5 receptors in angiogenesis.",
"Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.",
"Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.",
"Multiple signaling mechanisms of the UNC-6/netrin recepto... | [
2006,
2008,
2017,
2001,
2001,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
7404
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
26,
2,
14,
16,
25
] | 6 | true | Domain | Netrin receptor UNC5A-D-like, N-terminal domain | Netrin receptor UNC5A-D-like, N-terminal domain | UNC5A-D-like_N | 8 |
IPR057756 | 57,756 | Phosphatidylinositol 3-kinase type3/VPS34-like | PI3-kinase_type3/VPS34_cat | Domain | 5,015 | false | false | This entry represents the catalytic domain in mammal Phosphatidylinositol 3-kinase catalytic subunit type 3, yeast and plant PI3-kinase VPS34 and related PI3-kinases proteins. Phosphatidylinositol 3-kinase (PI3-kinases) can be divided into three main classes (I, II, and III), defined by their substrate specificity, reg... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd00896"
] | [
"PI3Kc_III"
] | [
5015
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.7.1.137",
"PWY-6352",
"R-CEL-1632852",
"R-CEL-1660514",
"R-CEL-1660516",
"R-CEL-1660517",
"R-CEL-5668599",
"R-DDI-1632852",
"R-DDI-1660514",
"R-DDI-1660516",
"R-DDI-1660517",
"R-DDI-5668599",
"R-HSA-109704",
"R-HSA-1632852",
"R-HSA-1660514",
"R-HSA-1660516",
"R-HSA-1660517",
"R-... | [
"EC:2.7.1.137",
"METACYC:PWY-6352",
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-1660514",
"REACTOME:R-CEL-1660516",
"REACTOME:R-CEL-1660517",
"REACTOME:R-CEL-5668599",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-1660514",
"REACTOME:R-DDI-1660516",
"REACTOME:R-DDI-1660517",
"REACTOME:R-DDI-5668599"... | 47 | [
"2x6f",
"2x6h",
"2x6i",
"2x6j",
"2x6k",
"3ihy",
"3ls8",
"4oys",
"4ph4",
"4uwf",
"4uwg",
"4uwh",
"4uwk",
"4uwl",
"5anl",
"5dfz",
"5enn",
"5kc2",
"6i3u",
"6ykg",
"7bl1",
"7rsj",
"7rsp",
"7rsv",
"8rxr",
"8sor",
"9c82",
"9dkp",
"9e4v",
"9mhf",
"9mhg",
"9mhh"... | 32 | [
"PUB00005469",
"PUB00046181",
"PUB00085383",
"PUB00092701",
"PUB00098178",
"PUB00112879",
"PUB00112880",
"PUB00112881",
"PUB00112882",
"PUB00112883",
"PUB00112884",
"PUB00112885",
"PUB00112886",
"PUB00112887",
"PUB00112888",
"PUB00112889"
] | [
"9255069",
"10580505",
"17371248",
"16467569",
"16839886",
"16835237",
"16473626",
"16390869",
"15861817",
"15691748",
"15551135",
"14617358",
"12967324",
"11927551",
"11756475",
"11581283"
] | [
"Phosphoinositide 3-kinases: a conserved family of signal transducers.",
"Structural insights into phosphoinositide 3-kinase catalysis and signalling.",
"Regulation of class III (Vps34) PI3Ks.",
"Regulation of membrane traffic by phosphoinositide 3-kinases.",
"Activation of the phosphatidylinositol 3-kinase... | [
1997,
1999,
2007,
2006,
2006,
2006,
2005,
2006,
2005,
2005,
2005,
2003,
2003,
2002,
2001,
2001
] | 16 | [
"IPR000403"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
5015
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
2,
3,
3,
1,
5,
4,
1,
1,
8
] | 12 | true | Domain | Phosphatidylinositol 3-kinase type3/VPS34-like | Phosphatidylinositol 3-kinase type3/VPS34-like | PI3-kinase_type3/VPS34_cat | 6 |
IPR057757 | 57,757 | UL78-like, Herpesvirus | UL78-like | Family | 97 | false | false | This entry represents the UL78 G protein-coupled receptor (GPCR) found in human cytomegalovirus (HCMV) and related betaherpesviruses. UL78 is one of four viral GPCRs encoded by HCMV, along with US27, US28, and UL33. Unlike the other three viral GPCRs that show approximately 30% similarity to chemokine receptors, UL78 d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25707"
] | [
"UL78"
] | [
97
] | 1 | [
"REACTOME"
] | [
"R-HSA-9609690"
] | [
"REACTOME:R-HSA-9609690"
] | 1 | [
"8z1e"
] | 1 | [
"PUB00160722",
"PUB00160823",
"PUB00160824",
"PUB00160825"
] | [
"38750025",
"22327422",
"22496149",
"34379494"
] | [
"A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.",
"The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments.",
"Human cytomegalovirus-encoded UL33 and UL78 heterom... | [
2024,
2012,
2012,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Betaherpesvirinae"
] | [
97
] | 1 | [] | [] | 0 | true | Family | UL78-like, Herpesvirus | UL78-like, Herpesvirus | UL78-like | 1 |
IPR057758 | 57,758 | UL74A-like, Cytomegalovirus | UL74A-like | Family | 57 | false | false | This entry represents the UL74A protein found in Human cytomegalovirus (HCMV). It is a small viral envelope protein of approximately 70 amino acids in length with a single transmembrane helix. The specific function of this protein remains to be determined, but it is localised to the virion membrane. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25727"
] | [
"UL74A"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Betaherpesvirinae",
"Homo sapiens"
] | [
56,
1
] | 2 | [
"Homo sapiens"
] | [
1
] | 1 | true | Family | UL74A-like, Cytomegalovirus | UL74A-like, Cytomegalovirus | UL74A-like | 9 |
IPR057760 | 57,760 | UL145-like, Cytomegalovirus | UL145-like | Family | 53 | false | false | This entry represents the human cytomegalovirus UL145 protein which exists in two isoforms: pUL145-Long and pUL145-Short. Both isoforms act as viral DDB1-cullin- associated factors (vDCAFs) that mimic cellular DCAFs to exploit the ubiquitin- proteasome system to impede antiviral immunity [ , ]. pUL145 recruits DDB1-con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25719"
] | [
"UL145"
] | [
53
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160720",
"PUB00160721"
] | [
"32075763",
"35938868"
] | [
"The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity.",
"Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex."
] | [
2020,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Cytomegalovirus"
] | [
53
] | 1 | [] | [] | 0 | true | Family | UL145-like, Cytomegalovirus | UL145-like, Cytomegalovirus | UL145-like | 4 |
IPR057761 | 57,761 | UL135-like, Cytomegalovirus | UL135-like | Family | 92 | false | false | This entry represents the Human cytomegalovirus UL135 protein, which remodels the actin cytoskeleton to impair immune recognition of infected cells [ ]. UL135 interacts directly with abl interactor 1 (ABI1) and ABI2 to recruit the WAVE2 regulatory complex to the plasma membrane, resulting in dramatic actin cytoskeleton... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25733"
] | [
"UL135"
] | [
92
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160719"
] | [
"25121749"
] | [
"HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Cytomegalovirus"
] | [
92
] | 1 | [] | [] | 0 | true | Family | UL135-like, Cytomegalovirus | UL135-like, Cytomegalovirus | UL135-like | 5 |
IPR057762 | 57,762 | UL128-like, Cytomegalovirus | UL128-like | Family | 68 | false | false | This entry represents the UL128 protein from human cytomegalovirus (HCMV), which is thought to a role in viral entry into host cells and be part of the viral pentameric complex (Pentamer). The Pentamer, comprising gH/gL/UL128/UL130/UL131A, is essential for HCMV entry into dendritic, endothelial, and epithelial cells. U... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25700"
] | [
"UL128"
] | [
68
] | 1 | [] | [] | [] | 0 | [
"5vob",
"5voc",
"5vod",
"7kbb",
"7m22",
"7m30",
"7t4q",
"7t4r",
"7t4s",
"8tea"
] | 10 | [
"PUB00160715",
"PUB00160716",
"PUB00160717",
"PUB00160718"
] | [
"28783665",
"35275718",
"35275719",
"37967532"
] | [
"Structural basis for potent antibody-mediated neutralization of human cytomegalovirus.",
"Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.",
"Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.",
"Single-cell analysis of memory B cel... | [
2017,
2022,
2022,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Betaherpesvirinae"
] | [
68
] | 1 | [] | [] | 0 | true | Family | UL128-like, Cytomegalovirus | UL128-like, Cytomegalovirus | UL128-like | 1 |
IPR057763 | 57,763 | Ubiquitin carboxyl-terminal hydrolase 40, ubiquitin-like domain | UBL_USP40 | Domain | 1,369 | false | false | This entry describes one of the ubiquitin-like (UBL) domains found in ubiquitin carboxyl-terminal hydrolase 40 (USP40) from animals. USP40 is a deubiquitinase (DUB) enzyme that belongs to the USP family [ , ]. The UBL domain of USP40 has been shown to interact with Yes-associated protein (YAP) [ ]. The number of UBL do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25822"
] | [
"UBL_USP40"
] | [
1369
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160712",
"PUB00160713",
"PUB00160714"
] | [
"30807924",
"24724799",
"38537774"
] | [
"USP7: Structure, substrate specificity, and inhibition.",
"Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains.",
"USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop."
] | [
2019,
2014,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1369
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
12
] | 4 | true | Domain | Ubiquitin carboxyl-terminal hydrolase 40, ubiquitin-like domain | Ubiquitin carboxyl-terminal hydrolase 40, ubiquitin-like domain | UBL_USP40 | 1 |
IPR057765 | 57,765 | PHD finger protein MALE STERILITY 1-like, ubiquitin-like domain | MS1-like_ubiquitin | Domain | 2,093 | false | false | This domain is found in MS1 and similar proteins found in plants. This domain is predicted to adopt an ubiquitin-like fold. PHD finger protein MALE STERILITY 1 (MS1) is a nuclear transcriptional activator essential for anther and post-meiotic pollen development and maturation. It plays a key role in tapetal development... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25565"
] | [
"Ubiquitin_At1g33420"
] | [
2093
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00134260",
"PUB00134261",
"PUB00160826"
] | [
"18032630",
"18032629",
"7824655"
] | [
"Arabidopsis MALE STERILITY1 encodes a PHD-type transcription factor and regulates pollen and tapetum development.",
"MALE STERILITY1 is required for tapetal development and pollen wall biosynthesis.",
"The fate of inflorescence meristems is controlled by developing fruits in Arabidopsis."
] | [
2007,
2007,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
2093
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
11,
18
] | 3 | true | Domain | PHD finger protein MALE STERILITY 1-like, ubiquitin-like domain | PHD finger protein MALE STERILITY 1-like, ubiquitin-like domain | MS1-like_ubiquitin | 9 |
IPR057767 | 57,767 | UGSC-like domain | UGSC-like_dom | Domain | 1,207 | false | false | This entry represents an uncharacterised domain in a group of bacterial proteins of unknown function. Some proteins represented by this entry are selenoproteins, which are characterised by a UGSC motif where U is a selenocysteine residue as described in . However, this residue is recoded from a stop codon, and most mat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24696"
] | [
"UGSC"
] | [
1207
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctrnx29",
"metagenomes"
] | [
39,
930,
29,
1,
208
] | 5 | [] | [] | 0 | true | Domain | UGSC-like domain | UGSC-like domain | UGSC-like_dom | 4 |
IPR057772 | 57,772 | Unconventional myosin-XVIIIa, SH3 domain | SH3_Myo18a | Domain | 3,385 | false | false | This entry represents the SH3 domain found in Myo18a. Unconventional myosin-XVIIIa (Myo18a) may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus [ , ]. In macrophages, it regulates trafficking, expression, and activation of innate immune receptors [ ]. The m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24556"
] | [
"SH3_Myosin-XVIIIa"
] | [
3385
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1839117",
"R-HSA-5655302",
"R-HSA-9703465"
] | [
"REACTOME:R-HSA-1839117",
"REACTOME:R-HSA-5655302",
"REACTOME:R-HSA-9703465"
] | 3 | [] | 0 | [
"PUB00039658",
"PUB00075143",
"PUB00088672",
"PUB00088673",
"PUB00088674",
"PUB00155839",
"PUB00155840"
] | [
"15944696",
"19837035",
"16982629",
"17597155",
"20217677",
"23345592",
"25965346"
] | [
"The structure of the myosin VI motor reveals the mechanism of directionality reversal.",
"GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding.",
"Functional characterization of the N-terminal region of myosin-2.",
"Evidence for an interaction betw... | [
2005,
2009,
2006,
2007,
2010,
2013,
2015
] | 7 | [
"IPR004009"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
3385
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
67,
5,
7,
9
] | 4 | true | Domain | Unconventional myosin-XVIIIa, SH3 domain | Unconventional myosin-XVIIIa, SH3 domain | SH3_Myo18a | 5 |
IPR057774 | 57,774 | UMOD/GP2/OIT3-like, D8C domain | D8C_UMOD/GP2/OIT3-like | Domain | 6,908 | false | false | This entry represents the D8C domain (cysteine-rich domain) found in UMOD, GP2, OIT3, VWDE and similar proteins mainly found in vertebrates. Uromodulin (UMOD), glycoprotein 2 (GP2) and oncoprotein-induced transcript 3 (OIT3) constitute a phylogenetically related protein family characterised by the presence of conserved... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23283"
] | [
"D8C_UMOD"
] | [
6908
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-163125",
"R-HSA-446203",
"R-HSA-9925561",
"R-MMU-163125",
"R-MMU-446203",
"R-RNO-163125",
"R-RNO-446203"
] | [
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9925561",
"REACTOME:R-MMU-163125",
"REACTOME:R-MMU-446203",
"REACTOME:R-RNO-163125",
"REACTOME:R-RNO-446203"
] | 7 | [
"6tqk",
"6zs5",
"6zya",
"7p6r",
"7p6s",
"7p6t",
"7pfp",
"7q3n",
"8xc5",
"9nu1",
"9nu2",
"9nu3"
] | 12 | [
"PUB00155597",
"PUB00155598",
"PUB00155599",
"PUB00160827",
"PUB00160828"
] | [
"35273390",
"33196145",
"32815518",
"15589826",
"22306318"
] | [
"Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.",
"Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.",
"The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.",
"Identi... | [
2022,
2020,
2020,
2004,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Polyangia"
] | [
6880,
28
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
65,
16,
9,
19
] | 4 | true | Domain | UMOD/GP2/OIT3-like, D8C domain | UMOD/GP2/OIT3-like, D8C domain | D8C_UMOD/GP2/OIT3-like | 4 |
IPR057775 | 57,775 | USP48 domain | USP48_dom | Domain | 110 | false | false | This entry represents a domain found towards the C-terminal of USP48 C. elegans and related sequences from nematodes. This domain is usually found in association with . In C.elegans, USP48 is required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24543"
] | [
"Usp-48"
] | [
110
] | 1 | [
"REACTOME"
] | [
"R-CEL-1169408"
] | [
"REACTOME:R-CEL-1169408"
] | 1 | [] | 0 | [
"PUB00155904"
] | [
"31088904"
] | [
"Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
110
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | USP48 domain | USP48 domain | USP48_dom | 4 |
IPR057776 | 57,776 | UTP23, sensor motif region | UTP23_sensor | Domain | 3,813 | false | false | This entry represents the sensor motif region found in the UTP23 protein. The sensor motif is located in the C-terminal region of UTP23 and recognises the snR30-ES6 three-way junction in the 18S rRNA. This interaction is crucial for the early stages of 90S pre-ribosome assembly and 18S rRNA processing. The sensor motif... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24779"
] | [
"UTP23_sensor"
] | [
3813
] | 1 | [] | [] | [] | 0 | [
"9g25",
"9g28"
] | 2 | [
"PUB00035397",
"PUB00067997"
] | [
"16762320",
"16769905"
] | [
"Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.",
"The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation."
] | [
2006,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Human immunodeficiency virus 2",
"marine sediment metagenome"
] | [
3811,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
3,
1,
3,
1,
2,
5,
1,
1,
3
] | 12 | true | Domain | UTP23, sensor motif region | UTP23, sensor motif region | UTP23_sensor | 1 |
IPR057777 | 57,777 | Vein, beta-barrel domain | Beta-barrel_vein | Domain | 227 | false | false | This entry includes vein protein from Drosophila, a secreted neuregulin-like EGFR ligand. It may play a role in the global proliferation of wing disc cells and the larval patterning [ ]. This entry represents a β-barrel domain found in vein, which is similar to that found in Tissue inhibitors of metalloproteinases (TIM... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24700"
] | [
"Vein_beta-barrel"
] | [
227
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-1227986",
"R-DME-1236394",
"R-DME-1250196",
"R-DME-1250342",
"R-DME-1250347",
"R-DME-1257604",
"R-DME-1358803",
"R-DME-1963640",
"R-DME-1963642",
"R-DME-5673001",
"R-DME-6785631",
"R-DME-6811558",
"R-DME-8863795"
] | [
"REACTOME:R-DME-1227986",
"REACTOME:R-DME-1236394",
"REACTOME:R-DME-1250196",
"REACTOME:R-DME-1250342",
"REACTOME:R-DME-1250347",
"REACTOME:R-DME-1257604",
"REACTOME:R-DME-1358803",
"REACTOME:R-DME-1963640",
"REACTOME:R-DME-1963642",
"REACTOME:R-DME-5673001",
"REACTOME:R-DME-6785631",
"REACTOM... | 13 | [] | 0 | [
"PUB00003030",
"PUB00004316",
"PUB00004928",
"PUB00009788",
"PUB00090665",
"PUB00091025"
] | [
"9804837",
"9208852",
"9892702",
"12145742",
"25758464",
"12821646"
] | [
"Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment.",
"Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.",
"Failure of spinal cord oligodendro... | [
1998,
1997,
1999,
2002,
2015,
2003
] | 6 | [] | [] | 0 | 0 | null | [
"Pancrustacea"
] | [
227
] | 1 | [
"Drosophila melanogaster"
] | [
5
] | 1 | true | Domain | Vein, beta-barrel domain | Vein, beta-barrel domain | Beta-barrel_vein | 6 |
IPR057778 | 57,778 | Vigilin, N-terminal KH domain | KH_Vigilin_N | Domain | 3,129 | false | false | This entry represents the first KH domain located at the N-terminal of Vigilin proteins. Vigilin, also known as high-density lipoprotein-binding protein (HDL-binding protein), is a ubiquitous and highly conserved RNA-binding protein that shuttles between the nucleus and cytoplasm, presumably in association with RNA mol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24668"
] | [
"KH_Vigilin"
] | [
3129
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8964011",
"R-MMU-8964011",
"R-RNO-8964011"
] | [
"REACTOME:R-HSA-8964011",
"REACTOME:R-MMU-8964011",
"REACTOME:R-RNO-8964011"
] | 3 | [] | 0 | [
"PUB00035584",
"PUB00113184",
"PUB00113190",
"PUB00113191",
"PUB00155695"
] | [
"14618268",
"8605996",
"15109574",
"26032007",
"36758804"
] | [
"The multi-KH protein vigilin associates with free and membrane-bound ribosomes.",
"Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus.",
"Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain.",
... | [
2003,
1996,
2004,
2015,
2023
] | 5 | [] | [] | 0 | 0 | null | [
"Chromobacterium indicum",
"Opisthokonta"
] | [
1,
3128
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
4,
2,
12,
10,
12,
1,
1
] | 8 | true | Domain | Vigilin, N-terminal KH domain | Vigilin, N-terminal KH domain | KH_Vigilin_N | 1 |
IPR057779 | 57,779 | Vps41, C-terminal RING finger | Znf_RING_Vps41 | Domain | 2,351 | false | false | This entry represents the C-terminal RING finger domain of Vps41. Eukaryotic cells utilise conserved membrane tethering complexes like CORVET and HOPS to regulate endomembrane fusion, with each complex comprising six subunits, including unique C-terminal zinc-finger domains. Biochemical studies in human CORVET and HOPS... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23555"
] | [
"zf-RING_Vps41"
] | [
2351
] | 1 | [
"REACTOME"
] | [
"R-HSA-9754560"
] | [
"REACTOME:R-HSA-9754560"
] | 1 | [] | 0 | [
"PUB00044536",
"PUB00053237",
"PUB00053238",
"PUB00099767",
"PUB00155935"
] | [
"9111041",
"10944212",
"9184222",
"23173123",
"28931724"
] | [
"Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.",
"A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.",
"Novel Golgi to vacuole delivery pa... | [
1997,
2000,
1997,
2013,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2351
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
2,
1,
5,
3,
3,
5,
9
] | 9 | true | Domain | Vps41, C-terminal RING finger | Vps41, C-terminal RING finger | Znf_RING_Vps41 | 5 |
IPR057780 | 57,780 | Vps41, beta-propeller | Beta-prop_Vps41 | Domain | 6,441 | false | false | This entry represents the N-terminal in Vsp41 proteins which contains a β-propeller. Vsp41 is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex, which is essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [ , , ]. Thi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23411"
] | [
"Beta-prop_Vps41"
] | [
6441
] | 1 | [
"REACTOME"
] | [
"R-HSA-9754560"
] | [
"REACTOME:R-HSA-9754560"
] | 1 | [
"7zu0"
] | 1 | [
"PUB00044536",
"PUB00053237",
"PUB00053238",
"PUB00099767",
"PUB00137029",
"PUB00155544"
] | [
"9111041",
"10944212",
"9184222",
"23173123",
"25908847",
"36098503"
] | [
"Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.",
"A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.",
"Novel Golgi to vacuole delivery pa... | [
1997,
2000,
1997,
2013,
2015,
2022
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
16,
6424,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
2,
11,
2,
1,
3,
6,
1,
1,
9
] | 12 | true | Domain | Vps41, beta-propeller | Vps41, beta-propeller | Beta-prop_Vps41 | 8 |
IPR057782 | 57,782 | YKL065W-A-like | YKL065W-A-like | Family | 11 | false | false | This protein family includes the uncharacterised protein YKL065W-A from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23488"
] | [
"YKL065W-A"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155509"
] | [
"29897761"
] | [
"Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
11
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | YKL065W-A-like | YKL065W-A-like | YKL065W-A-like | 1 |
IPR057783 | 57,783 | YKL104W-A | YKL104W-A | Family | 7 | false | false | This protein family includes the uncharacterised protein YKL104W-A from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23478"
] | [
"YKL104W-A"
] | [
7
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155509"
] | [
"29897761"
] | [
"Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
7
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | YKL104W-A | YKL104W-A | YKL104W-A | 2 |
IPR057784 | 57,784 | YlcJ-like | YlcJ-like | Family | 21 | false | false | This protein family includes YlcJ from Escherichia coli [ ], a 49-residue-long sequence predicted to adopt an α-helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23688"
] | [
"YlcJ"
] | [
21
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae",
"Escherichia phage 4A7"
] | [
20,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YlcJ-like | YlcJ-like | YlcJ-like | 3 |
IPR057785 | 57,785 | YLR146W-A-like | YLR146W-A-like | Family | 39 | false | false | This protein family includes the Coiled-coil domain-containing protein YLR146W-A from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF) whose function is unknown [ ]. This protein is predicted to adopt an α-helical structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23482"
] | [
"YLR146W-A"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155509",
"PUB00160829"
] | [
"29897761",
"12775844"
] | [
"Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae.",
"Finding functional features in Saccharomyces genomes by phylogenetic footprinting."
] | [
2018,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
39
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | YLR146W-A-like | YLR146W-A-like | YLR146W-A-like | 6 |
IPR057786 | 57,786 | YmgL-like | YmgL-like | Family | 39 | false | false | This protein family includes YmgL from Escherichia coli, a 36-residue-long sequence predicted to adopt an α-helical configuration. It is expressed at approximately equal levels during exponential growth and stationary phase in rich growth medium [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23691"
] | [
"YmgL"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
39
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YmgL-like | YmgL-like | YmgL-like | 2 |
IPR057787 | 57,787 | YmgM | YmgM | Family | 6 | false | false | This protein family includes YmgM from Escherichia coli [ ], a 67-residue-long sequence with unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23693"
] | [
"YmgM"
] | [
6
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae",
"human gut metagenome"
] | [
5,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YmgM | YmgM | YmgM | 2 |
IPR057788 | 57,788 | YmiD | YmiD | Family | 10 | false | false | This protein family includes the uncharacterised protein YmiD from Escherichia coli, a 42-residue micropeptide encoded by a small open reading frame (smORF). Proteins 50 or fewer residues long have been shown to regulate the functions of larger proteins in a variety of organisms. It is expressed in both exponential and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23497"
] | [
"YmiD"
] | [
10
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Escherichia"
] | [
10
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YmiD | YmiD | YmiD | 7 |
IPR057789 | 57,789 | YmjE-like | YmjE-like | Family | 55 | false | false | This protein family includes Protein YmjE from Escherichia coli [ ], a 54-residue-long sequence with an unknown function. It is expressed at approximately equal levels during exponential growth and the stationary phase in rich growth medium. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23692"
] | [
"YmjE"
] | [
55
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
55
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YmjE-like | YmjE-like | YmjE-like | 4 |
IPR057792 | 57,792 | YnfS-like | YnfS-like | Family | 17 | false | false | This protein family includes Protein YnfS from Escherichia coli [ ], a 29-residue-long sequence encoded in the Qin prophage. It is predicted to adopt an α-helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23697"
] | [
"YnfS"
] | [
17
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
17
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YnfS-like | YnfS-like | YnfS-like | 4 |
IPR057793 | 57,793 | YnfU-like | YnfU-like | Family | 221 | false | false | This protein family includes the putative zinc-binding protein YnfU, encoded in the Qin prophage from Escherichia coli, and similar sequences mainly from proteobacteria. YnfU is a 56-residue micropeptide encoded by a small open reading frame (smORF). Proteins 50 or fewer residues long have been shown to regulate the fu... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF038384",
"PF23499"
] | [
"zinc_YnfU_fam",
"YnfU"
] | [
217,
183
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified Caudoviricetes",
"viral metagenome"
] | [
217,
3,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YnfU-like | YnfU-like | YnfU-like | 3 |
IPR057794 | 57,794 | YnhH-like | YnhH-like | Family | 13 | false | false | This protein family includes Protein YnhH from Escherichia coli, a 64-residue-long microprotein encoded by a small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23642"
] | [
"YnhH-like"
] | [
13
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155925"
] | [
"34662240"
] | [
"Identification of novel translated small ORFs in <i>Escherichia coli</i> using complementary ribosome profiling approaches."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
13
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YnhH-like | YnhH-like | YnhH-like | 4 |
IPR057795 | 57,795 | YodE | YodE | Family | 5 | false | false | This protein family includes Protein YodE from Escherichia coli, a 48-residue micropeptide encoded by a small open reading frame (smORF) that overlaps on the same strand with small regulatory RNA RyeG. Proteins of 50 or fewer residues long have been shown to regulate the functions of larger proteins in a variety of org... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23504"
] | [
"YodE"
] | [
5
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
5
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YodE | YodE | YodE | 8 |
IPR057796 | 57,796 | YOMG-like, N-terminal domain | YOMG-like_N | Domain | 180 | false | false | This entry represents the N-terminal domain of SPbeta prophage-derived uncharacterised protein YomG from Bacillus subtilis (strain 168). This domain adopts a β-barrel fold and is usually found in association with a neighbour prophage endopeptidase tail domain ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24049"
] | [
"YOMG_N"
] | [
180
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Caudoviricetes"
] | [
150,
30
] | 2 | [] | [] | 0 | true | Domain | YOMG-like, N-terminal domain | YOMG-like, N-terminal domain | YOMG-like_N | 4 |
IPR057798 | 57,798 | YqeB, PH domain | PH_YqeB | Domain | 1,154 | false | false | This entry represents a PH domain in YqeB from Bacillus subtilis and related bacterial proteins. These proteins contain 2 transmembrane helices and a bacterial PH domain that includes an unusual α/β/β/α subdomain. The function of these proteins is unknown. They contain a C-terminal domain related to an anticodon bindin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23494"
] | [
"bPH_10"
] | [
1154
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
1154
] | 1 | [] | [] | 0 | true | Domain | YqeB, PH domain | YqeB, PH domain | PH_YqeB | 6 |
IPR057799 | 57,799 | YqfI-like | YqfI-like | Family | 58 | false | false | This protein family includes Protein YqfI from Escherichia coli [ ], a 27-residues long sequence predicted to adopt an α-helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23690"
] | [
"YqfI"
] | [
58
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
58
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YqfI-like | YqfI-like | YqfI-like | 1 |
IPR057800 | 57,800 | YqgG-like | YqgG-like | Family | 32 | false | false | This protein family includes Protein YqgG from Escherichia coli, a 47-residue micropeptide encoded by a small open reading frame (smORF) found antisense to yqgC. Proteins 50 or fewer residues long have been shown to regulate the functions of larger proteins in a variety of organisms [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23505"
] | [
"YqgG"
] | [
32
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
32
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YqgG-like | YqgG-like | YqgG-like | 8 |
IPR057801 | 57,801 | YqgH-like | YqgH-like | Family | 13 | false | false | This protein family includes Protein YqgH from Escherichia coli, a 27-residue micropeptide encoded by a small open reading frame (smORF). Proteins 50 or fewer residues long have been shown to regulate the functions of larger proteins in a variety of organisms [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23506"
] | [
"YqgH"
] | [
13
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Escherichia"
] | [
13
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YqgH-like | YqgH-like | YqgH-like | 5 |
IPR057802 | 57,802 | YqhI domain | YqhI_dom | Domain | 2,991 | false | false | This entry describes an uncharacterised domain that covers the whole length of YqhI from Escherichia coli [ ]. YqhI is a 47-residue-long protein encoded by a small open reading frame (smORF). This domain also covers the N-terminal of uncharacterised proteins that also contain . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23678"
] | [
"YqhI"
] | [
2991
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Symbiodiniaceae",
"metagenomes"
] | [
2974,
3,
14
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YqhI domain | YqhI domain | YqhI_dom | 8 |
IPR057803 | 57,803 | YqiM | YqiM | Family | 8 | false | false | This protein family includes YqiM from Escherichia coli, a 27-residue micropeptide encoded by a small open reading frame (smORF). Proteins of 50 or fewer residues long have been shown to regulate the functions of larger proteins in a variety of organisms [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23507"
] | [
"YqiM"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Escherichia coli"
] | [
8
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YqiM | YqiM | YqiM | 7 |
IPR057804 | 57,804 | YsdD | YsdD | Family | 32 | false | false | This protein family includes YsdD from Escherichia coli [ ], a 26-residue-long sequence. YsdD is expressed during the stationary phase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23700"
] | [
"YsdD"
] | [
32
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae"
] | [
32
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YsdD | YsdD | YsdD | 9 |
IPR057806 | 57,806 | YtiC | YtiC | Family | 8 | false | false | This protein family includes YtiC from Escherichia coli [ ], a 33-residue-long sequence predicted to adopt an α-helical configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23685"
] | [
"YtiC"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067",
"PUB00160830"
] | [
"29645342",
"28851853"
] | [
"Identifying New Small Proteins in Escherichia coli.",
"Translational Repression of the RpoS Antiadapter IraD by CsrA Is Mediated via Translational Coupling to a Short Upstream Open Reading Frame."
] | [
2018,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Escherichia coli"
] | [
8
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YtiC | YtiC | YtiC | 8 |
IPR057808 | 57,808 | YxiG | YxiG | Family | 160 | false | false | This family includes proteins related to B. subtilis YxiG. This protein forms a single compact all-β domain that is predicted to homodimerise [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24711"
] | [
"YxiG"
] | [
160
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095685"
] | [
"28189581"
] | [
"Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
159,
1
] | 2 | [] | [] | 0 | true | Family | YxiG | YxiG | YxiG | 5 |
IPR057812 | 57,812 | YKFC, SH3b2 domain | SH3_YKFC_2nd | Domain | 1,213 | false | false | This entry represents the second of two N-terminal bacterial SH3 (SH3b2) domains found in bacterial dipeptidyl-peptidases VI such as Gamma-D-glutamyl-L-lysine dipeptidyl-peptidase (YKFC). YKFC consist of three domains ( ), the N-terminal SH3b1 ( ), SH3b2 and a C-terminal NlpC/P60 ( ). The active site is located at the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23795"
] | [
"SH3_YKFC_2nd"
] | [
1213
] | 1 | [] | [] | [] | 0 | [
"3h41"
] | 1 | [
"PUB00091551"
] | [
"20944232"
] | [
"Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"leotiomyceta",
"marine sediment metagenome"
] | [
1187,
25,
1
] | 3 | [] | [] | 0 | true | Domain | YKFC, SH3b2 domain | YKFC, SH3b2 domain | SH3_YKFC_2nd | 9 |
IPR057813 | 57,813 | YhiY | YhiY | Family | 24 | false | false | This protein family includes Protein YhiY from Escherichia coli, a 37-residues micropeptide encoded by a small open reading frame (smORF). Proteins 50 or fewer residues-long have been shown to regulate the functions of larger proteins in a variety of organisms [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23514"
] | [
"YhiY"
] | [
24
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105763"
] | [
"30837344"
] | [
"Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacteriaceae",
"human gut metagenome"
] | [
23,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YhiY | YhiY | YhiY | 5 |
IPR057814 | 57,814 | YecU-like | YecU | Family | 52 | false | false | This protein family includes Protein YecU from Escherichia coli [ ], a 58-residues long protein encoded by a small open reading frame (smORF). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23680"
] | [
"YecU"
] | [
52
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106067"
] | [
"29645342"
] | [
"Identifying New Small Proteins in Escherichia coli."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
52
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YecU-like | YecU-like | YecU | 5 |
IPR057815 | 57,815 | C2CD5, C-terminal domain | C2CD5_C | Domain | 3,750 | false | false | This entry represents the YbjQ-like domain at the C-terminal in C2 domain-containing protein 5 (C2CD5). C2CD5 is involved in insulin-stimulated glucose transport and the translocation of the glucose transporter SLC2A4/GLUT4 from intracellular glucose storage vesicles to the plasma membrane in adipocytes. This process i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23128"
] | [
"C2CD5_C"
] | [
3750
] | 1 | [
"REACTOME"
] | [
"R-HSA-1445148"
] | [
"REACTOME:R-HSA-1445148"
] | 1 | [] | 0 | [
"PUB00068956"
] | [
"21907143"
] | [
"C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3750
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
50,
4,
4,
4,
10
] | 5 | true | Domain | C2CD5, C-terminal domain | C2CD5, C-terminal domain | C2CD5_C | 8 |
IPR057816 | 57,816 | YBR230W-A | YBR230W-A | Family | 22 | false | false | This protein family includes the uncharacterised protein YBR230W-A from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23485"
] | [
"YBR230W-A"
] | [
22
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155509"
] | [
"29897761"
] | [
"Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
22
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | YBR230W-A | YBR230W-A | YBR230W-A | 8 |
IPR057819 | 57,819 | T4 y05I-like putative transcription factor, N-terminal domain | T4_y05I_N | Domain | 263 | false | false | This entry represents the N-terminal domain of family of uncharacterised phage protein that includes T4 y05I protein . The family also includes homologues from T2 and T6 phage among others. These proteins contain two domains. These domains appear to be related to those found in the eukaryotic PurA transcription factor.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24449"
] | [
"T4_y05I_N"
] | [
263
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
263
] | 1 | [] | [] | 0 | true | Domain | T4 y05I-like putative transcription factor, N-terminal domain | T4 y05I-like putative transcription factor, N-terminal domain | T4_y05I_N | 1 |
IPR057820 | 57,820 | T4 y05I-like putative transcription factor, C-terminal domain | T4_y05I_C | Domain | 302 | false | false | This entry represents the C-terminal domain of a family of uncharacterised phage proteins that includes T4 y05I protein . The family also includes homologues from T2 and T6 phage, among others. These proteins contain two domains. These domains appear to be related to those found in the eukaryotic PurA transcription fac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24448"
] | [
"T4_y05I_C"
] | [
302
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroides thetaiotaomicron",
"Viruses"
] | [
1,
301
] | 2 | [] | [] | 0 | true | Domain | T4 y05I-like putative transcription factor, C-terminal domain | T4 y05I-like putative transcription factor, C-terminal domain | T4_y05I_C | 7 |
IPR057821 | 57,821 | XPB-like, C-terminal domain | XPB_C | Domain | 40 | false | false | This domain is found at the C-terminal end of TFIIH basal transcription factor complex helicase/translocase XPB subunit from Trypanosoma brucei and related proteins from similar species. This domain is predicted to adopt an α/β configuration. This domain is found next to and appears to be unique in XBP in Trypanosoma. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24482"
] | [
"XPB_C"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057247",
"PUB00062805",
"PUB00062813",
"PUB00076972",
"PUB00160831"
] | [
"14534314",
"10024882",
"21592869",
"25641424",
"17259543"
] | [
"Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.",
"Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.",
"A history of TFIIH: two decades of molecular biology on a pivotal transcription... | [
2003,
1999,
2011,
2015,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
40
] | 1 | [] | [] | 0 | true | Domain | XPB-like, C-terminal domain | XPB-like, C-terminal domain | XPB_C | 4 |
IPR057823 | 57,823 | RCD1, WWE domain | WWE_RCD1 | Domain | 2,348 | false | false | This entry represents a WWE domain found in a family of plant proteins, which includes probable inactive ADP-ribosyltransferases that are involved in the regulation of oxidative stress, hormonal and developmental responses in Arabidopsis thaliana. Members of the family, such as SRO1 and RCD1, may regulate stress-respon... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23467"
] | [
"WWE_5"
] | [
2348
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2348
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
24,
23,
61
] | 3 | true | Domain | RCD1, WWE domain | RCD1, WWE domain | WWE_RCD1 | 3 |
IPR057825 | 57,825 | SEC23-DDH2, WWE domain | WWE_SEC23-DDH2 | Domain | 3,173 | false | false | This entry represents a WWE domain found in the PA-PLA1 proteins including SEC23-interacting protein (Sec23ip) and Triacylglycerol hydrolase DDHD2 (DDHD2). Sec23ip plays a role in the organisation of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23464"
] | [
"WWE_3"
] | [
3173
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1483166",
"R-HSA-204005",
"R-MMU-1483166",
"R-MMU-204005"
] | [
"REACTOME:R-HSA-1483166",
"REACTOME:R-HSA-204005",
"REACTOME:R-MMU-1483166",
"REACTOME:R-MMU-204005"
] | 4 | [] | 0 | [
"PUB00126412",
"PUB00126413",
"PUB00160931",
"PUB00160933",
"PUB00160935",
"PUB00160936"
] | [
"10400679",
"15623529",
"24599962",
"22922100",
"29278326",
"37832604"
] | [
"p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins.",
"p125 is localized in endoplasmic reticulum exit sites and involved in their organization.",
"Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.",
"Roles of ... | [
1999,
2005,
2014,
2012,
2018,
2023
] | 6 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3173
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
13,
8,
7
] | 5 | true | Domain | SEC23-DDH2, WWE domain | SEC23-DDH2, WWE domain | WWE_SEC23-DDH2 | 9 |
IPR057826 | 57,826 | C20G8.02-like, WWE domain | WWE_C20G8.02 | Domain | 2,270 | false | false | This entry represents a WWE domain found in Probable phospholipase C20G8.02, mitochondrial from Schizosaccharomyces pombe, Phospholipase SGR2 from Arabidopsis thaliana and similar eukaryotic proteins. C20G8.02 is likely to have a phospholipase activity that hydrolyzes phosphatidic acid. SGR2 is involved in the vacuolar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23463"
] | [
"WWE_2"
] | [
2270
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.1.-",
"PWY-1921",
"PWY-5835",
"PWY-6190",
"PWY-6308",
"PWY-6322",
"PWY-6339",
"PWY-6415",
"PWY-6558",
"PWY-6848",
"PWY-7002",
"PWY-7352",
"PWY-7367",
"PWY-7521",
"PWY-7599",
"PWY-7660",
"PWY-7712",
"PWY-7713",
"PWY-7730",
"PWY-7769",
"PWY-7982",
"PWY-8058",
"PWY-8143... | [
"EC:3.1.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5835",
"METACYC:PWY-6190",
"METACYC:PWY-6308",
"METACYC:PWY-6322",
"METACYC:PWY-6339",
"METACYC:PWY-6415",
"METACYC:PWY-6558",
"METACYC:PWY-6848",
"METACYC:PWY-7002",
"METACYC:PWY-7352",
"METACYC:PWY-7367",
"METACYC:PWY-7521",
"METACYC:PWY-7... | 34 | [] | 0 | [
"PUB00161592",
"PUB00161593"
] | [
"11826297",
"16344262"
] | [
"SGR2, a phospholipase-like protein, and ZIG/SGR4, a SNARE, are involved in the shoot gravitropism of Arabidopsis.",
"Gravitropism in leaves of Arabidopsis thaliana (L.) Heynh."
] | [
2002,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2270
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
2,
1,
2,
12
] | 6 | true | Domain | C20G8.02-like, WWE domain | C20G8.02-like, WWE domain | WWE_C20G8.02 | 8 |
IPR057827 | 57,827 | WW domain, fungi | WW_fungi | Domain | 1,193 | false | false | This entry represents a set of WW domains that are found in a large family of fungal RasGEF domain-containing proteins. This domain is found close to the N-terminal of the proteins adjacent to an SH3 domain . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23518"
] | [
"WW_2"
] | [
1193
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1193
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | WW domain, fungi | WW domain, fungi | WW_fungi | 3 |
IPR057828 | 57,828 | ZNF142, C2H2 zinc finger 13 | Znf_C2H2_ZNF142_13th | Domain | 1,002 | false | false | This entry represents the 13th C2H2 zinc finger in human ZNF142 and related proteins. In mice ZNF142 and related proteins, this domain can be found in a different position. Zinc finger protein 142 (ZNF142) plays a role in nervous system development. It is thought to be involved in transcriptional regulation. This prote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23574"
] | [
"zf-C2H2_ZNF142_18"
] | [
1002
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035808",
"PUB00035809",
"PUB00035811",
"PUB00043274",
"PUB00160833"
] | [
"11361095",
"10664601",
"10940247",
"18253864",
"38296634"
] | [
"Three classes of C2H2 zinc finger proteins.",
"The origin of prokaryotic C2H2 zinc finger regulators.",
"DNA recognition by Cys2His2 zinc finger proteins.",
"Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains.",
"<i>ZNF142</i> mutation causes sex-dependent neuro... | [
2001,
2000,
2000,
2008,
2024
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1002
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4,
4
] | 4 | true | Domain | ZNF142, C2H2 zinc finger 13 | ZNF142, C2H2 zinc finger 13 | Znf_C2H2_ZNF142_13th | 5 |
IPR057829 | 57,829 | ZNF142, C2H2 zinc finger 21/23 | Znf_C2H2_ZN142_21/23 | Domain | 851 | false | false | This entry represents the 21st and 23rd C2H2 zinc finger in human ZNF142 and related proteins. In mice ZNF142 and related proteins, this domain can be found in a different position. Zinc finger protein 142 (ZNF142) plays a role in nervous system development. It is thought to be involved in transcriptional regulation. T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23612"
] | [
"zf-C2H2_ZN142"
] | [
851
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035808",
"PUB00035809",
"PUB00035811",
"PUB00043274",
"PUB00160833"
] | [
"11361095",
"10664601",
"10940247",
"18253864",
"38296634"
] | [
"Three classes of C2H2 zinc finger proteins.",
"The origin of prokaryotic C2H2 zinc finger regulators.",
"DNA recognition by Cys2His2 zinc finger proteins.",
"Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains.",
"<i>ZNF142</i> mutation causes sex-dependent neuro... | [
2001,
2000,
2000,
2008,
2024
] | 5 | [
"IPR013087"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"marine sediment metagenome"
] | [
850,
1
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
4
] | 3 | true | Domain | ZNF142, C2H2 zinc finger 21/23 | ZNF142, C2H2 zinc finger 21/23 | Znf_C2H2_ZN142_21/23 | 2 |
IPR057830 | 57,830 | ZNF462, N-terminal C2H2 zinc finger | Znf_C2H2_ZNF462_N | Domain | 1,197 | false | false | This entry represents a C2H2 zinc finger at the N-terminal in the human ZNF462 and related proteins. Zinc finger protein 462 (ZNF462) is involved in transcription by regulating chromatin structure and organisation [ , ]. ZNF462 is a multidomain protein that contains a number of classical C2H2 zinc fingers. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23223"
] | [
"zf-C2H2_ZNF462"
] | [
1197
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155929",
"PUB00155930"
] | [
"20219459",
"21570965"
] | [
"Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.",
"ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1197
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
2,
2
] | 4 | true | Domain | ZNF462, N-terminal C2H2 zinc finger | ZNF462, N-terminal C2H2 zinc finger | Znf_C2H2_ZNF462_N | 3 |
IPR057831 | 57,831 | ZNF462, C2H2 zinc finger 1 | Znf_C2H2_ZNF462_1st | Domain | 1,242 | false | false | This entry represents the first C2H2 zinc finger in the human ZNF462 and related proteins. This domain can be found in a different position in other ZNF462 proteins. Zinc finger protein 462 (ZNF462) is involved in transcription by regulating chromatin structure and organisation [ , ]. ZNF462 is a multidomain protein th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23077"
] | [
"zf-C2H2_ZNF462_1st"
] | [
1242
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155929",
"PUB00155930"
] | [
"20219459",
"21570965"
] | [
"Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.",
"ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Methanococcoides alaskense"
] | [
1241,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
1,
2
] | 4 | true | Domain | ZNF462, C2H2 zinc finger 1 | ZNF462, C2H2 zinc finger 1 | Znf_C2H2_ZNF462_1st | 6 |
IPR057832 | 57,832 | ZNF462, C2H2 zinc finger 2 | Znf_C2H2_ZNF462_2nd | Domain | 1,375 | false | false | This entry represents the second C2H2 zinc finger in the human ZNF462 and related proteins. This domain can be found in a different position in other ZNF462 proteins. Zinc finger protein 462 (ZNF462) is involved in transcription by regulating chromatin structure and organisation [ , ]. ZNF462 is a multidomain protein t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23224"
] | [
"zf-C2H2_2nd_ZNF462"
] | [
1375
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155929",
"PUB00155930"
] | [
"20219459",
"21570965"
] | [
"Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.",
"ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate."
] | [
2010,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1375
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
1,
2
] | 4 | true | Domain | ZNF462, C2H2 zinc finger 2 | ZNF462, C2H2 zinc finger 2 | Znf_C2H2_ZNF462_2nd | 4 |
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