LiteFold/InterPro · Datasets at Hugging Face

IPR059899

59,899

Sll1247, N-terminal helical domain

Sll1247_N

Domain

444

false

This entry represents the N-terminal helical domain of uncharacterised protein sll1247 from Synechocystis sp. PCC 6803 and related cyanobacteria. The gene is located adjacent to murF, which encodes UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase involved in peptidoglycan biosynthesis [ ]. The specific functi...

[]

0

[ "PFAM" ]

[ "PF27130" ]

[ "Sll1247_N" ]

[ 444 ]

1

[]

0

[]

0

[ "PUB00162298" ]

[ "7894708" ]

[ "Characterization of the murF gene of the cyanobacterium Synechocystis sp. PCC 6803." ]

[ 1995 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 444 ]

1

[]

0

true

Domain

Sll1247, N-terminal helical domain

Sll1247_N

6

IPR059900

59,900

Bacteriophage T4 protein Y07C, C-terminal domain

Phage_T4_Y07C_C

Domain

290

false

This entry represents the The C-terminal domain of Y07C protein family found in T4-like bacteriophages. Y07C is an uncharacterised protein of 136 amino acids (16.0 kDa) found in the segB-ipI intergenic region of bacteriophage T4.

[]

0

[ "PFAM" ]

[ "PF26894" ]

[ "Phage_T4_Y07C" ]

[ 290 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 29, 251, 10 ]

3

[]

0

true

Domain

Bacteriophage T4 protein Y07C, C-terminal domain

Phage_T4_Y07C_C

6

IPR059901

59,901

ACE1/SLTA, small beta-sheet domain

ACE1/SLTA_beta

Domain

1,045

false

This entry represents a small β-sheet domain found in ACE1/SLTA transcription factor proteins. ACE1 is a Cys2-His2 zinc finger transcription factor that binds to the promoter of the cbh1 gene and activates transcription [ ]. The protein is localised to the nucleus and plays a role in regulation of cellulase gene expres...

[]

0

[ "PFAM" ]

[ "PF28347" ]

[ "ACE1_beta" ]

[ 1045 ]

1

[]

0

[]

0

[ "PUB00161780", "PUB00162559" ]

[ "10681571", "33431412" ]

[ "Isolation of the ace1 gene encoding a Cys(2)-His(2) transcription factor involved in regulation of activity of the cellulase promoter cbh1 of Trichoderma reesei.", "The C2H2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A an...

[ 2000, 2021 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1045 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

ACE1/SLTA, small beta-sheet domain

ACE1/SLTA_beta

9

IPR059902

59,902

YpuD, C-terminal domain

YpuD_C

Domain

142

false

This entry represents the C-terminal domain of YpuD proteins. The domain is a putative DNA-binding domain found in bacteria, predominantly in Bacillota with representatives in Bacilli class, including Bacillaceae. The function of this domain remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27401" ]

[ "YpuD_C" ]

[ 142 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus phage Stahl", "Bacteria" ]

[ 1, 141 ]

2

[]

0

true

Domain

YpuD, C-terminal domain

YpuD_C

7

IPR059903

59,903

Aq_1262-like lipoprotein

Aq_1262

Family

423

false

This entry represents a family of uncharacterised bacterial lipoproteins. The prototype member aq_1262 from Aquifex aeolicus strain VF5 is a 564 amino acid lipoprotein that is anchored to the cell membrane via lipid modification. The protein contains a signal peptide and a conserved lipobox motif that directs lipidatio...

[]

0

[ "PFAM" ]

[ "PF27085" ]

[ "Aq_1262" ]

[ 423 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 422, 1 ]

2

[]

0

true

Family

Aq_1262-like lipoprotein

Aq_1262

3

IPR059905

59,905

STT4, N-terminal

TPR_STT4

Domain

1,271

false

This is a region of tetratricopeptide (TPR)-like repeats found at the N-terminal of yeast Phosphatidylinositol 4-kinase STT4, which acts in the first committed step in the production of the second messenger inositol 1,4,5-trisphosphate.

[]

0

[ "PFAM" ]

[ "PF28151" ]

[ "TPR_STT4" ]

[ 1271 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-1483248", "R-SCE-1660514" ]

[ "REACTOME:R-SCE-1483248", "REACTOME:R-SCE-1660514" ]

2

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1271 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

STT4, N-terminal

TPR_STT4

7

IPR059906

59,906

Y4kK, N-terminal domain

Y4kK_N

Domain

532

false

This entry represents the N-terminal domain of Y4kK, an uncharacterised protein from Sinorhizobium fredii. The specific function of this N-terminal domain remains unknown. Y4kK protein is encoded on the symbiotic plasmid pNGR234a and belongs to the COG1404 functional category, the N-terminal is represented by and the c...

[]

0

[ "PFAM" ]

[ "PF27160" ]

[ "Y4kK_N" ]

[ 532 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 8, 517, 7 ]

3

[]

0

true

Domain

Y4kK, N-terminal domain

Y4kK_N

9

IPR059907

59,907

DUF1631, 2nd domain

DUF1631_2nd

Domain

3,793

false

This entry represents the second domain found in DUF1631 family of proteins. The members of this family are sequences derived from a group of hypothetical proteins expressed by certain beta and gammaproteobacteria species.

[]

0

[ "PFAM" ]

[ "PF26671" ]

[ "DUF1631_2nd" ]

[ 3793 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3719, 7, 67 ]

3

[]

0

true

Domain

DUF1631, 2nd domain

DUF1631_2nd

7

IPR059908

59,908

Uncharacterised protein HI_1054, middle domain

HI_1054_M

Domain

632

false

This entry represents a domain found in the middle region of the uncharacterised protein HI_1054 from Haemophilus influenzae and related sequences from bacteria. The function of this protein remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27365" ]

[ "HI_1054" ]

[ 632 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Glomeromycetes", "Methanobacteriota", "ecological metagenomes" ]

[ 613, 11, 2, 6 ]

4

[]

0

true

Domain

Uncharacterised protein HI_1054, middle domain

HI_1054_M

1

IPR059909

59,909

Flavobacterium inter-domain disulphide bond domain

FIDD

Domain

6,392

false

This entry represents a stalk domain found in flavobacterium presumed fibrillar adhesins. The FIDD (Flavobacterium Inter-domain Disulphide bond Domain) domain contains two conserved cystine residues that form inter-domain disulphide bonds presumably stabilising the protein stalk.

[]

0

[ "PFAM" ]

[ "PF26689" ]

[ "FIDD" ]

[ 6392 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Protostomia", "ecological metagenomes" ]

[ 6361, 5, 26 ]

3

[]

0

true

Domain

Flavobacterium inter-domain disulphide bond domain

FIDD

1

IPR059910

59,910

SpdB plasmid transfer protein, N-terminal transmembrane domain

SpdB_N

Domain

249

false

This entry represents the N-terminal transmembrane domain of SpdB, a plasmid transfer protein from Streptomyces species. SpdB is encoded on conjugative plasmids such as pIJ101 from Streptomyces lividans and functions in bacterial conjugation. This N-terminal domain contains three transmembrane helices that anchor the p...

[]

0

[ "PFAM" ]

[ "PF27080" ]

[ "SpdB_N" ]

[ 249 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Streptomyces phage SF3" ]

[ 248, 1 ]

2

[]

0

true

Domain

SpdB plasmid transfer protein, N-terminal transmembrane domain

SpdB_N

1

IPR059911

59,911

MJ1433, C-terminal helical domain

MJ1433_C

Domain

486

false

This entry represents the C-terminal α-helical domain of the uncharacterized protein MJ1433 from Methanocaldococcus jannaschii. This protein contains two predicted transmembrane helices. This C-terminal helical domain is distinct from the transmembrane regions and is predicted to be cytoplasmic. The function of this pr...

[]

0

[ "PFAM" ]

[ "PF27232" ]

[ "MJ1433_C" ]

[ 486 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Kipferlia bialata", "Methanobacteriati", "ecological metagenomes" ]

[ 260, 2, 188, 36 ]

4

[]

0

true

Domain

MJ1433, C-terminal helical domain

MJ1433_C

8

IPR059912

59,912

Uncharacterised protein YwmA

YwmA

Family

119

false

This entry represents a family of uncharacterised proteins found in bacteria, including protein YwmA from Bacillus subtilis. The function of this protein family remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27472" ]

[ "YwmA" ]

[ 119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 118, 1 ]

2

[]

0

true

Family

Uncharacterised protein YwmA

YwmA

6

IPR059913

59,913

Y4lK

Family

115

false

This entry represents Y4lK, an uncharacterised protein from Sinorhizobium fredii. This protein is found predominantly in Alphaproteobacteria. The function of this protein remains to be determined [ ].

[]

0

[ "PFAM" ]

[ "PF27494" ]

[ "Y4lK" ]

[ 115 ]

1

[]

0

[]

0

[ "PUB00004254" ]

[ "9163424" ]

[ "Molecular basis of symbiosis between Rhizobium and legumes." ]

[ 1997 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 115 ]

1

[]

0

true

Family

Y4lK

1

IPR059914

59,914

Interferon-induced very large GTPase 1, N-terminal domain

GVIN1_N

Domain

503

false

This domain is found at the N-terminal end of mouse Interferon-induced very large GTPase 1 (GVIN1 or VLIG-1) and similar proteins mainly found in vertebrates. Members of this group play a role in conserved immune functions [ ]. This domain is predicted to adopt an all-alpha structure.

[]

0

[ "PFAM" ]

[ "PF26771" ]

[ "GVIN1_N" ]

[ 503 ]

1

[]

0

[]

0

[ "PUB00161632" ]

[ "19369598" ]

[ "The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates." ]

[ 2009 ]

1

[]

0

null

[ "Metazoa" ]

[ 503 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 2 ]

3

true

Domain

Interferon-induced very large GTPase 1, N-terminal domain

GVIN1_N

2

IPR059915

59,915

Probable beta-glucosidase btgE, N-terminal domain

BtgE_N

Domain

819

false

This entry represents the N-terminal domain found in probable beta-glucosidase btgE from Aspergillus species and related fungi. This domain is found within the larger glycosyl hydrolase enzyme. The btgE protein is involved in cellulose degradation and belongs to glycosyl hydrolase family 17. The enzyme catalyses the hy...

[]

0

[ "PFAM" ]

[ "PF28457" ]

[ "BtgE_N" ]

[ 819 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.1.21", "PWY-3121", "PWY-5176", "PWY-6002", "PWY-6788", "PWY-7091", "PWY-7092", "PWY-7913" ]

[ "EC:3.2.1.21", "METACYC:PWY-3121", "METACYC:PWY-5176", "METACYC:PWY-6002", "METACYC:PWY-6788", "METACYC:PWY-7091", "METACYC:PWY-7092", "METACYC:PWY-7913" ]

8

[]

0

[ "PUB00161836" ]

[ "18404212" ]

[ "Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." ]

[ 2008 ]

1

[]

0

null

[ "Nostoc punctiforme NIES-2108", "Opisthokonta" ]

[ 1, 818 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Probable beta-glucosidase btgE, N-terminal domain

BtgE_N

2

IPR059916

59,916

Phage ORF13 coiled-coil protein

Phage_ORF13_CC

Family

114

false

This entry represents ORF13 found in bacteriophages. The prototype is from Helicobacter pylori bacteriophage KHP30, a 186 amino acid protein with a molecular weight of 21.8 kDa. The protein contains two predicted coiled-coil domains and has been characterised by direct protein sequencing. The mature protein lacks the N...

[]

0

[ "PFAM" ]

[ "PF26854" ]

[ "Phage_ORF13_CC" ]

[ 114 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Campylobacterales", "Schmidvirus", "hydrothermal vent metagenome" ]

[ 110, 3, 1 ]

3

[]

0

true

Family

Phage ORF13 coiled-coil protein

Phage_ORF13_CC

8

IPR059917

59,917

Rv0461-like membrane protein

Rv0461

Family

323

false

This entry represents a family of uncharacterised membrane proteins found in mycobacteria. The prototype member Rv0461 from Mycobacterium tuberculosis is a 200 amino acid multi-pass membrane protein containing three predicted transmembrane helices. The protein also contains a disordered region. Recent proteogenomic stu...

[]

0

[ "PFAM" ]

[ "PF27066" ]

[ "Rv0461" ]

[ 323 ]

1

[]

0

[]

0

[ "PUB00162283" ]

[ "34915127" ]

[ "Deep N-terminomics of Mycobacterium tuberculosis H37Rv extensively correct annotated encoding genes." ]

[ 2022 ]

1

[]

0

null

[ "Mycobacteriaceae" ]

[ 323 ]

1

[]

0

true

Family

Rv0461-like membrane protein

Rv0461

2

IPR059918

59,918

AF_1575

Domain

104

false

This entry represents a domain found in AF_1575 family of uncharacterised proteins found predominantly in archaea and some bacteria. The proteins are approximately 200-250 amino acids in length and contain predicted signal peptides, suggesting they are secreted or membrane-associated. The function of this protein famil...

[]

0

[ "PFAM" ]

[ "PF27293" ]

[ "AF_1575" ]

[ 104 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Methanobacteriota" ]

[ 53, 51 ]

2

[]

0

true

Domain

AF_1575

3

IPR059919

59,919

YjcN

Family

512

false

This entry represents YjcN, an uncharacterised protein from Bacillus subtilis. YjcN is a 106 amino acid protein (gene BSU11920) that contains an N-terminal signal peptide and is predicted to be secreted. The mature protein is 75 amino acids in length. The protein is found in Gram-positive bacteria and is conserved in t...

[]

0

[ "PFAM" ]

[ "PF27204" ]

[ "YjcN" ]

[ 512 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 512 ]

1

[]

0

true

Family

YjcN

9

IPR059920

59,920

Histidine triad hairpin domain

His-triad_hairpin

Domain

756

false

This small domain is found repeated in a number of uncharacterised eukaryotic proteins. It is predicted to fold into a β-hairpin which contains three highly conserved histidine residues forming a Hx(2)HxH sequence motif. These histidine residues may be involved in a metal coordination. This domain also contains two hig...

[]

0

[ "PFAM" ]

[ "PF28209" ]

[ "His-triad_hairpin" ]

[ 756 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta", "Pseudoalteromonas arctica" ]

[ 754, 2 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Histidine triad hairpin domain

His-triad_hairpin

5

IPR059921

59,921

XepA-like domain

XepA

Domain

108

false

This entry represents a domain found in XepA proteins from Bacillus and related phage systems. XepA is a protein of approximately 279 amino acids that adopts a jelly roll fold structure. The protein is encoded by the defective prophage PBSX in Bacillus subtilis and related phage elements [ , ]. XepA does not appear to ...

[]

0

[ "PFAM" ]

[ "PF27453" ]

[ "XepA" ]

[ 108 ]

1

[]

0

[ "6i56", "6i5o", "6ia5" ]

3

[ "PUB00006403", "PUB00162400" ]

[ "9555893", "7921239" ]

[ "Lysis genes of the Bacillus subtilis defective prophage PBSX.", "Lytic enzymes associated with defective prophages of Bacillus subtilis: sequencing and characterization of the region comprising the N-acetylmuramoyl-L-alanine amidase gene of prophage PBSX." ]

[ 1998, 1994 ]

2

[]

0

null

[ "Bacillota", "Caudoviricetes", "marine sediment metagenome" ]

[ 102, 2, 4 ]

3

[]

0

true

Domain

XepA-like domain

XepA

5

IPR059922

59,922

MJ0753, N-terminal domain

MJ0753_N

Domain

105

false

This entry represents the N-terminal domain of the MJ0753 family of proteins found predominantly in methanogenic archaea and some bacteria. The full-length proteins are approximately 210 amino acids and contain predicted signal peptides, suggesting they are secreted proteins. This N-terminal domain contains a conserved...

[]

0

[ "PFAM" ]

[ "PF27309" ]

[ "MJ0753_N" ]

[ 105 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 73, 19, 13 ]

3

[]

0

true

Domain

MJ0753, N-terminal domain

MJ0753_N

4

IPR059923

59,923

Rv0497-like, C-terminal domain

Rv0497-like_C

Domain

1,105

false

This entry represents a C-terminal domain found in Rv0497-like proteins from Mycobacterium species. These uncharacterised multi-pass membrane proteins are approximately 310-355 amino acids in size and contain three C-terminal transmembrane helices. The domain encompasses the transmembrane region and includes helical se...

[]

0

[ "PFAM" ]

[ "PF27548" ]

[ "Rv0497_C" ]

[ 1105 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 1104, 1 ]

2

[]

0

true

Domain

Rv0497-like, C-terminal domain

Rv0497-like_C

6

IPR059924

59,924

TP_0179

Family

199

false

This entry represents TP_0179, an uncharacterised protein found in Spirochaetota, primarily in Treponema and Leptospira species. TP_0179 from Treponema pallidum is 627 amino acids in length and contains multiple disordered regions and low complexity regions.

[]

0

[ "PFAM" ]

[ "PF27359" ]

[ "TP_0179" ]

[ 199 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rotaria magnacalcarata", "Spirochaetia", "ecological metagenomes" ]

[ 7, 190, 2 ]

3

[]

0

true

Family

TP_0179

2

IPR059925

59,925

CAP22/SCP41 domain

CAP22/SCP41_dom

Domain

1,196

false

This entry represents a domain found in CAP22 from Colletotrichum gloeosporioides, SCP41 from Verticillium dahliae and similar fungal sequences, which contains helical regions with interspersed disordered segments. This entry is found in fungi, particularly plant pathogens such as Verticillium species. These proteins a...

[]

0

[ "PFAM" ]

[ "PF28223" ]

[ "CAP22" ]

[ 1196 ]

1

[]

0

[]

0

[ "PUB00161844" ]

[ "29757140" ]

[ "The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity." ]

[ 2018 ]

1

[]

0

null

[ "Dikarya" ]

[ 1196 ]

1

[]

0

true

Domain

CAP22/SCP41 domain

CAP22/SCP41_dom

4

IPR059926

59,926

SPbeta prophage protein YorH

Phage_SPbeta_YorH

Family

188

false

This entry represents the YorH protein family found in SPbeta prophages. YorH is an uncharacterised protein of 156 amino acids found in the temperate bacteriophage SPbeta that infects Bacillus species.

[]

0

[ "PFAM" ]

[ "PF26927" ]

[ "Phage_SPbeta_YorH" ]

[ 188 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Viruses" ]

[ 133, 55 ]

2

[]

0

true

Family

SPbeta prophage protein YorH

Phage_SPbeta_YorH

8

IPR059927

59,927

Immunity protein TsiV2

TsiV2

Family

402

false

This entry represents TsiV2 immunity proteins found in Vibrionaceae. TsiV2 is a membrane protein of approximately 242 amino acids that functions as an immunity protein protecting against VasX toxin [ ]. The protein contains three transmembrane helical regions and helix hairpin structures. TsiV2 prevents early activatio...

[]

0

[ "PFAM" ]

[ "PF27447" ]

[ "TsiV2" ]

[ 402 ]

1

[]

0

[]

0

[ "PUB00101267" ]

[ "24348240" ]

[ "Dual expression profile of type VI secretion system immunity genes protects pandemic Vibrio cholerae." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria" ]

[ 402 ]

1

[]

0

true

Family

Immunity protein TsiV2

TsiV2

9

IPR059928

59,928

MimR domain

MimR

Domain

632

false

This domain is found in Propane 2-monooxygenase operon transcriptional activator MimR from Mycolicibacterium smegmatis and related proteins. MimR acts as a transcriptional activator of the mimABCD operon encoding the propane 2-monooxygenase complex [ ]. This domain is predicted to show a twisted β-sheet with α-helices ...

[]

0

[ "PFAM" ]

[ "PF26961" ]

[ "MimR" ]

[ 632 ]

1

[]

0

[]

0

[ "PUB00162158" ]

[ "21856847" ]

[ "Identification of the regulator gene responsible for the acetone-responsive expression of the binuclear iron monooxygenase gene cluster in mycobacteria." ]

[ 2011 ]

1

[]

0

null

[ "Actinomycetota" ]

[ 632 ]

1

[]

0

true

Domain

MimR domain

MimR

1

IPR059929

59,929

Y4kD-like, C-terminal domain

Y4kD_C

Domain

181

false

This entry represents the C-terminal domain of Y4kD proteins found in bacteria. Y4kD proteins are found on plasmids in Sinorhizobium species. The full-length Y4kD protein is approximately 549 amino acids. The specific function of this C-terminal domain remains to be determined. This domain is also found in Probable pro...

[]

0

[ "PFAM" ]

[ "PF27295" ]

[ "Y4kD_C" ]

[ 181 ]

1

[]

0

[]

0

[ "PUB00100796" ]

[ "35025633" ]

[ "Bacterial gasdermins reveal an ancient mechanism of cell death." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Tanacetum cinerariifolium" ]

[ 180, 1 ]

2

[]

0

true

Domain

Y4kD-like, C-terminal domain

Y4kD_C

5

IPR059930

59,930

MJ0565 integral membrane domain

MJ0565

Family

86

false

This entry represents the MJ0565 integral membrane domain found in methanogenic archaea. This protein contains four predicted transmembrane helices, indicating it forms an integral membrane domain. The function remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27307" ]

[ "MJ0565" ]

[ 86 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Phycicoccus endophyticus" ]

[ 85, 1 ]

2

[]

0

true

Family

MJ0565 integral membrane domain

MJ0565

2

IPR059931

59,931

YomU/Tube protein family

YomU_Tube

Family

419

false

This entry represents the YomU/Tube protein family found in Bacillus subtilis and related bacteriophages. YomU is a prophage-derived protein from the SPbeta prophage, while the tail tube protein is found in Bacillus phage SPR. The phage tail tube protein interacts with the bacterial defense protein DSR2, inducing confo...

[]

0

[ "PFAM" ]

[ "PF27173" ]

[ "YomU_Tube" ]

[ 419 ]

1

[]

0

[ "8k98", "8wfn", "8wks", "8wya", "8wyb", "8wyc", "8xff", "8xkn", "8ygc", "8ygf", "8ygk", "8ygm", "8ygn", "8ygo", "8ygp", "8yln", "8z18", "8zc9", "8ztr", "9jgh", "9jgi" ]

21

[ "PUB00161911" ]

[ "36192536" ]

[ "Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "bioreactor metagenome" ]

[ 315, 4, 99, 1 ]

4

[]

0

true

Family

YomU/Tube protein family

YomU_Tube

8

IPR059932

59,932

YrzR-like, zinc ribbon domain

YrzR_Zn_ribbon

Domain

1,388

false

This entry represents a putative zinc ribbon domain found in YrzR and related proteins from Bacillus subtilis and other bacteria. These are small proteins of approximately 63 amino acids that likely coordinate zinc ions through conserved cysteine and/or histidine residues characteristic of zinc ribbon motifs. The YrzR ...

[]

0

[ "PFAM" ]

[ "PF27112" ]

[ "YrzR_Zn_ribbon" ]

[ 1388 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "ecological metagenomes" ]

[ 1384, 4 ]

2

[]

0

true

Domain

YrzR-like, zinc ribbon domain

YrzR_Zn_ribbon

6

IPR059933

59,933

ISOC1, N-terminal ubiquitin-like domain

Ubiq_ISOC1_N

Domain

612

false

This entry represents the N-terminal ubiquitin-like domain found in isochorismatase domain-containing protein 1 (ISOC1) and related proteins. ISOC1 contains two main domains: this N-terminal ubiquitin-like domain and a C-terminal isochorismatase catalytic domain. Ubiquitin-like domains are small regulatory modules that...

[]

0

[ "PFAM" ]

[ "PF26960" ]

[ "Ubiq_ISOC1_N" ]

[ 612 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Deuterostomia" ]

[ 612 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 4 ]

4

true

Domain

ISOC1, N-terminal ubiquitin-like domain

Ubiq_ISOC1_N

5

IPR059934

59,934

Phage tail protein-like, small four-stranded beta-sheet domain

Phage_tail_beta

Domain

1,688

false

This entry represents a small domain found in phage tail proteins, particularly in tail fibers and depolymerases. The domain forms a four-stranded β-sheet structure and is approximately 65-70 amino acids in length. This domain is found in various phage proteins involved in host recognition and attachment, including cap...

[]

0

[ "PFAM" ]

[ "PF27114" ]

[ "Phage_tail_beta" ]

[ 1688 ]

1

[]

0

[ "5w5p", "5w6p", "5w6s", "6c72", "6e1r", "6tgf", "6w4q", "7lzj", "7vyv", "7vz3", "7xyc", "8iq5", "8iq9", "8iqe" ]

14

[ "PUB00160653", "PUB00161848", "PUB00162253", "PUB00162254", "PUB00162255" ]

[ "30706654", "33947754", "27916936", "34768992", "28077636" ]

[ "Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types.", "Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity.", "Capsule-Targeting Depolymerase, Derived from Klebsiella K...

[ 2019, 2021, 2016, 2021, 2017 ]

5

[]

0

null

[ "Bacteria", "Candidatus Nitrosocosmicus", "Eukaryota", "Viruses", "metagenomes" ]

[ 1346, 2, 5, 332, 3 ]

5

[]

0

true

Domain

Phage tail protein-like, small four-stranded beta-sheet domain

Phage_tail_beta

8

IPR059935

59,935

Probable transporter, N-terminal domain

Transporter_N

Domain

535

false

This entry represents an N-terminal transmembrane helix of a Probable transporter found in uncharacterised bacterial proteins. This domain is usually found in combination with a probable periplasmic core domain similar to the domain of MacB ABC transporter proteins.

[]

0

[ "PFAM" ]

[ "PF28574" ]

[ "Transporter_N" ]

[ 535 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "FCB group", "metagenomes" ]

[ 524, 11 ]

2

[]

0

true

Domain

Probable transporter, N-terminal domain

Transporter_N

6

IPR059936

59,936

Valyl--tRNA ligase modifier

ValRS_modifier

Family

289

false

The Valyl--tRNA ligase modifier family is involved in interacting with the host's valyl--tRNA ligase, specifically in Escherichia coli. This interaction alters several physicochemical properties of the ligase, which may affect its function in protein synthesis. The modification of the valyl--tRNA ligase by this family ...

[]

0

[ "PFAM" ]

[ "PF26829" ]

[ "ValRS_modifier" ]

[ 289 ]

1

[]

0

[]

0

[ "PUB00162370", "PUB00162371", "PUB00162372" ]

[ "163351", "1103442", "19475" ]

[ "Temporal appearance of bacteriophage T4-modified valyl tRNA synthetase in Escherichia coli.", "A gene of bacteriophage T4 controlling the modification of host valy-tRNA synthetase.", "Purification and properties of a T4 bacteriophage factor that modifies valyl-tRNA synthetase of Escherichia coli." ]

[ 1975, 1975, 1977 ]

3

[]

0

null

[ "Pseudomonadati", "Viruses" ]

[ 4, 285 ]

2

[]

0

true

Family

Valyl--tRNA ligase modifier

ValRS_modifier

1

IPR059937

59,937

AF_1845, START domain-like

START_AF_1845

Domain

861

false

This entry represents a domain found in AF_1845, an uncharacterised protein from Archaeoglobus fulgidus. AF_1845 is a 288 amino acid protein (gene AF_1845) that contains an N-terminal signal peptide and is predicted to be secreted. This domain adopts a structure similar to the START (StAR-related lipid transfer) domain...

[]

0

[ "PFAM" ]

[ "PF27226" ]

[ "AF_1845" ]

[ 861 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 19, 830, 12 ]

3

[]

0

true

Domain

AF_1845, START domain-like

START_AF_1845

5

IPR059938

59,938

BilD, N-terminal domain

BilD_N

Domain

145

false

This entry represents the N-terminal domain of BilD proteins found in bacteria. BilD is a bacterial E1-like protein that functions as a component of the Bil antiviral defence system [ ]. The full-length BilD protein activates ubiquitin-like BilA by adenylating its C-terminal glycine residue with ATP and conjugating it ...

[]

0

[ "PFAM" ]

[ "PF27312" ]

[ "BilD_N" ]

[ 145 ]

1

[]

0

[]

0

[ "PUB00160357" ]

[ "39020165" ]

[ "Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "ecological metagenomes" ]

[ 138, 3, 4 ]

3

[]

0

true

Domain

BilD, N-terminal domain

BilD_N

7

IPR059939

59,939

YfdI, C-terminal transmembrane domain

YfdI_C

Domain

914

false

This entry represents the N-terminal domain of uncharacterised protein YfdI from Escherichia coli and related enterobacteria. It is predicted to be a multi-pass membrane protein localised to the cell membrane with ten transmembrane helices.

[]

0

[ "PFAM" ]

[ "PF27133" ]

[ "YfdI_N" ]

[ 914 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 913, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YfdI, C-terminal transmembrane domain

YfdI_C

2

IPR059940

59,940

Putative lipoprotein LppJ

LppJ

Family

418

false

This entry represents the putative lipoprotein LppJ found in the Mycobacterium tuberculosis complex. The protein is 187 amino acids in length and contains an N-terminal signal peptide that is cleaved during processing. The mature protein is anchored to the cell membrane via lipid modifications at the N-terminal cystein...

[]

0

[ "PFAM" ]

[ "PF27220" ]

[ "LppJ" ]

[ 418 ]

1

[]

0

[]

0

[ "PUB00162132" ]

[ "21969609" ]

[ "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry." ]

[ 2011 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 418 ]

1

[]

0

true

Family

Putative lipoprotein LppJ

LppJ

4

IPR059941

59,941

PhoA-like, N-terminal domain

PhoA-like_N

Domain

1,160

false

This entry represents the N-terminal domain in putative alkaline phosphatases (PhoA), from fungi. PhoA acts as a non-specific phosphomonoesterase to hydrolyse phosphate esters, optimally at high pH [ ]. This domain appears to be specific to PhoA proteins mainly from Ascomycota, but not all, as PhoA from Saccharomyces c...

[]

0

[ "PFAM" ]

[ "PF26732" ]

[ "PhoA-like_N" ]

[ 1160 ]

1

[]

0

[]

0

[ "PUB00038439" ]

[ "15938627" ]

[ "Metal specificity is correlated with two crucial active site residues in Escherichia coli alkaline phosphatase." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1160 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

PhoA-like, N-terminal domain

PhoA-like_N

9

IPR059943

59,943

Type II restriction enzyme MjaV

MjaV

Family

74

false

This entry represents the MjaV family of type II restriction endonucleases found predominantly in bacteria. The family is found mainly in Verrucomicrobiota, particularly Verrucomicrobiaceae. The prototype enzyme MjaV from Methanocaldococcus jannaschii recognises the double-stranded sequence 5'-GTAC-3' and performs endo...

[]

0

[ "PFAM" ]

[ "PF27324" ]

[ "MjaV" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00099965" ]

[ "12654995" ]

[ "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 12, 50, 12 ]

3

[]

0

true

Family

Type II restriction enzyme MjaV

MjaV

5

IPR059944

59,944

TP_0584, C-terminal domain

TP_0584_C

Domain

64

false

This entry represents the C-terminal domain of TP_0584 proteins. The domain is found predominantly in Spirochaetota, with representatives in Treponema and Spirochaeta genera within Spirochaetales order. The function of this domain remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27395" ]

[ "TP_0584_C" ]

[ 64 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Aphis craccivora", "Spirochaetia" ]

[ 1, 63 ]

2

[]

0

true

Domain

TP_0584, C-terminal domain

TP_0584_C

1

IPR059945

59,945

YGL041W-A, C-terminal domain

YGL041W_C

Domain

682

false

This entry represents the C-terminal domain of YGL041W-A and its homologues from fungi. YGL041W-A is an uncharacterised mitochondrial protein in Saccharomyces cerevisiae. The protein contains a predicted mitochondrial transit peptide at the N-terminal and this domain is located at the C-terminal after a disordered regi...

[]

0

[ "PFAM" ]

[ "PF28567" ]

[ "YGL041W_C" ]

[ 682 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 682 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

YGL041W-A, C-terminal domain

YGL041W_C

9

IPR059946

59,946

TP_0700

Family

61

false

This entry represents a group of uncharacterised proteins of approximately 130 amino acids found in bacteria. The domain contains single α-helices involved in coiled-coils and is found predominantly in Spirochaetota, with representatives in Treponema and Spirochaeta genera within Spirochaetales order. The function of t...

[]

0

[ "PFAM" ]

[ "PF27400" ]

[ "TP_0700" ]

[ 61 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 61 ]

1

[]

0

true

Family

TP_0700

5

IPR059947

59,947

PXO2-28, C-terminal domain

PXO2_28_C

Domain

255

false

This entry represents the C-terminal domain of pXO2-28 proteins found in Bacillus anthracis and related Bacilli. This domain is found in a protein of approximately 497 amino acids encoded on the virulence plasmid pXO2. The C-terminal region contains a disordered segment with acidic residue bias. The function of this do...

[]

0

[ "PFAM" ]

[ "PF27438" ]

[ "PXO2_28_C" ]

[ 255 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 255 ]

1

[]

0

true

Domain

PXO2-28, C-terminal domain

PXO2_28_C

8

IPR059948

59,948

Probable transporter, C-terminal domain

Transporter_C

Domain

536

false

This entry represents an C-terminal transmembrane helices of a Probable transporter found in uncharacterised bacterial proteins. This domain is usually found in combination with a probable periplasmic core domain similar to the domain of MacB ABC transporter proteins.

[]

0

[ "PFAM" ]

[ "PF28576" ]

[ "Transporter_C" ]

[ 536 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 520, 16 ]

2

[]

0

true

Domain

Probable transporter, C-terminal domain

Transporter_C

4

IPR059949

59,949

Aq_1264, transmembrane helical domain

Aq_1264_TM

Domain

654

false

This entry represents a transmembrane helical domain found in Aq_1264, an uncharacterised multi-pass membrane protein from the hyperthermophilic bacterium Aquifex aeolicus. The full-length protein contains eight predicted transmembrane helices and is predicted to localise to the cell membrane. This domain is often foun...

[]

0

[ "PFAM" ]

[ "PF27139" ]

[ "Aq_1264_TM" ]

[ 654 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 607, 47 ]

2

[]

0

true

Domain

Aq_1264, transmembrane helical domain

Aq_1264_TM

5

IPR059950

59,950

Biotrophy-associated secreted protein 4

BAS4

Family

873

false

This entry represents the biotrophy-associated secreted protein 4 (BAS4) found in plant pathogenic fungi. The prototype protein from Pyricularia oryzae (rice blast fungus) is a secreted effector protein with a predicted signal peptide for secretion. BAS4 is involved in biotrophic colonisation of plant cells and plays a...

[]

0

[ "PFAM" ]

[ "PF28414" ]

[ "BAS4" ]

[ 873 ]

1

[]

0

[]

0

[ "PUB00161823", "PUB00161824" ]

[ "19357089", "31049006" ]

[ "Interaction transcriptome analysis identifies Magnaporthe oryzae BAS1-4 as Biotrophy-associated secreted proteins in rice blast disease.", "The biotrophy-associated secreted protein 4 (BAS4) participates in the transition of Magnaporthe oryzae from the biotrophic to the necrotrophic phase." ]

[ 2009, 2019 ]

2

[]

0

null

[ "Dikarya" ]

[ 873 ]

1

[]

0

true

Family

Biotrophy-associated secreted protein 4

BAS4

5

IPR059951

59,951

At4g18257, C-terminal domain

At4g18257_C

Domain

535

false

This entry represents the C-terminal coiled-coil domain found in At4g18257, an uncharacterised protein from Arabidopsis thaliana and related plant proteins. The domain spans approximately 62 residues and forms a predicted coiled-coil structure. The protein is classified as CCDC174-like based on sequence similarity and ...

[]

0

[ "PFAM" ]

[ "PF28424" ]

[ "At4g18257_C" ]

[ 535 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viridiplantae" ]

[ 535 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 3 ]

3

true

Domain

At4g18257, C-terminal domain

At4g18257_C

7

IPR059952

59,952

ZEB2-like, helical domain

ZEB2_helical

Domain

674

false

This entry represents a helical domain found in ZEB2 and related transcription factors involved in secondary metabolite biosynthesis in fungi. ZEB2 is a bZIP family transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes [ ]. Related proteins are involved in the regul...

[]

0

[ "PFAM" ]

[ "PF28575" ]

[ "ZEB2_helical" ]

[ 674 ]

1

[]

0

[]

0

[ "PUB00162430", "PUB00162431" ]

[ "25412204", "16262793" ]

[ "Identification of the biosynthetic gene clusters for the lipopeptides fusaristatin A and W493 B in Fusarium graminearum and F. pseudograminearum.", "Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae." ]

[ 2014, 2005 ]

2

[]

0

null

[ "leotiomyceta" ]

[ 674 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

ZEB2-like, helical domain

ZEB2_helical

1

IPR059953

59,953

AcrB ubiquitination network protein, Ig-like domain

Ig-like_AcrB

Domain

1,039

false

This entry represents the Ig-like domain in Probable ubiquitination network signaling protein acrB from fungi. The acrB proteins are involved in the regulatory network that controls carbon source utilisation through processes of ubiquitination and deubiquitination. They interact with other components such as creA, creB...

[]

0

[ "PFAM" ]

[ "PF26747" ]

[ "Ig-like_AcrB" ]

[ 1039 ]

1

[]

0

[]

0

[ "PUB00162057" ]

[ "12750323" ]

[ "Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: a gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme." ]

[ 2003 ]

1

[]

0

null

[ "Pezizomycotina" ]

[ 1039 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

AcrB ubiquitination network protein, Ig-like domain

Ig-like_AcrB

5

IPR059954

59,954

ABC-2 membrane transporter-related

ABC-2_memb-rel

Domain

2,610

false

This domain is found in uncharacterised bacterial proteins. It shares similarity with members of the ABC-2 membrane transporter superfamily. It is predicted to contain six transmembrane helices. This model doesn't include the last C-terminal helix.

[]

0

[ "PFAM" ]

[ "PF26999" ]

[ "ABC-2_memb_rel" ]

[ 2610 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 2609, 1 ]

2

[]

0

true

Domain

ABC-2 membrane transporter-related

ABC-2_memb-rel

6

IPR059955

59,955

YdhW domain

YdhW_C

Domain

473

false

This entry represents the a domain that is found repeated in the YdhW protein from Escherichia coli, a protein that is part of the ydhYVWXUT operon (locus b1672). In some members this domain is found only once, at the C-terminal. The expression of YdhW is up-regulated by the oxygen-responsive transcription factor FNR u...

[]

0

[ "PFAM" ]

[ "PF27264" ]

[ "YdhW_C" ]

[ 473 ]

1

[]

0

[]

0

[ "PUB00104519" ]

[ "18227264" ]

[ "Characterization of the Escherichia coli K-12 ydhYVWXUT operon: regulation by FNR, NarL and NarP." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Panagrolaimus superbus", "metagenomes" ]

[ 467, 1, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YdhW domain

YdhW_C

2

IPR059957

59,957

Uncharacterized protein AF_1314, C-terminal domain

AF_1314_C

Domain

133

false

This entry represents the C-terminal domain of the uncharacterized protein AF_1314 from Archaeoglobus fulgidus. The protein contains an N-terminal Rossmann-fold NAD(P)-binding domain, whilst this C-terminal domain is distinct from the nucleotide-binding region. This domain is also found in some bacteria. The specific f...

[]

0

[ "PFAM" ]

[ "PF27252" ]

[ "AF_1314_C" ]

[ 133 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 83, 48, 2 ]

3

[]

0

true

Domain

Uncharacterized protein AF_1314, C-terminal domain

AF_1314_C

5

IPR059959

59,959

tRNA hydrolase-like, thioredoxin-like domain

tRNA-like_Thioredoxin-liek

Domain

1,016

false

This entry represents the Thioredoxin-like domain in putative tRNA hydrolases and uncharacterised proteins from fungi. Members of this clan are small redox-active proteins that mediate thiol-disulfide exchange through a conserved active-site disulfide bond. They share a characteristic thioredoxin fold, consisting of a ...

[]

0

[ "PFAM" ]

[ "PF26958" ]

[ "tRNA-like_Thioredoxin-liek" ]

[ 1016 ]

1

[]

0

[]

0

[ "PUB00115488" ]

[ "15558583" ]

[ "Structural classification of thioredoxin-like fold proteins." ]

[ 2005 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1016 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

tRNA hydrolase-like, thioredoxin-like domain

tRNA-like_Thioredoxin-liek

3

IPR059960

59,960

TnsB transposase, helix-turn-helix domain

HTH_TnsB

Domain

1,426

false

This entry represents a helix-turn-helix domain found in TnsB, the transposase component of bacterial transposon Tn7. TnsB is a sequence-specific DNA-binding protein that recognises sequences necessary for recombination at both left and right ends of Tn7 [ ]. The protein contains multiple DNA-binding domains that conta...

[]

0

[ "PFAM" ]

[ "PF27135" ]

[ "HTH_TnsB" ]

[ 1426 ]

1

[]

0

[ "7pik" ]

1

[ "PUB00162042" ]

[ "35654042" ]

[ "Structural basis of transposon end recognition explains central features of Tn7 transposition systems." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Discina gigas", "metagenomes" ]

[ 1419, 1, 6 ]

3

[]

0

true

Domain

TnsB transposase, helix-turn-helix domain

HTH_TnsB

4

IPR059961

59,961

Bacteriophage P22 ejection protein gp16

Phage_P22_gp16

Family

704

false

This entry represents gp16, one of three ejection proteins found in bacteriophage P22 that infects Salmonella enterica. Gp16, along with gp7 and gp20, is packaged inside the procapsid during phage assembly. These ejection proteins are required to facilitate transport of bacteriophage P22 double-stranded DNA safely thro...

[]

0

[ "PFAM" ]

[ "PF26808" ]

[ "Phage_P22_gp16" ]

[ 704 ]

1

[]

0

[]

0

[ "PUB00160647", "PUB00160648" ]

[ "29590587", "26245366" ]

[ "Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release.", "Bacteriophage P22 ejects all of its internal proteins before its genome." ]

[ 2018, 2015 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 673, 31 ]

2

[]

0

true

Family

Bacteriophage P22 ejection protein gp16

Phage_P22_gp16

3

IPR059962

59,962

SF2091/S2213 domain

SF2091

Domain

71

false

This entry represents a small uncharacterised domain in proteins of approximately 119 amino acids found in bacteria. This domain is primarily found in Pseudomonadota, with representatives in both Gammaproteobacteria and Betaproteobacteria. Members include protein SF2091.1/S2213 from Shigella flexneri and related protei...

[]

0

[ "PFAM" ]

[ "PF27383" ]

[ "SF2091" ]

[ 71 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 70, 1 ]

2

[]

0

true

Domain

SF2091/S2213 domain

SF2091

9

IPR059963

59,963

AF_0136, N-terminal domain

AF_0136_N

Domain

38

false

This entry represents the N-terminal domain of the AF_0136 family of uncharacterised proteins found in methanogenic archaea. The full-length proteins are approximately 185 amino acids in length and contain both N-terminal and C-terminal domains. The function of this N-terminal domain remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27315" ]

[ "AF_0136_N" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 38 ]

1

[]

0

true

Domain

AF_0136, N-terminal domain

AF_0136_N

4

IPR059964

59,964

Triquetra cystein-rich domain

Triquetra_S-S

Domain

34

false

This domain is found in uncharacterised proteins from Choanoflagellates. It contains four pairs of highly conserved cysteine residues which are predicted to form disulfide bonds. The polypeptide chain path defines a shape with similarity to Triquetra symbol.

[]

0

[ "PFAM" ]

[ "PF26750" ]

[ "Triquetra_S-S" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Salpingoecidae" ]

[ 34 ]

1

[]

0

true

Domain

Triquetra cystein-rich domain

Triquetra_S-S

9

IPR059966

59,966

PF3D7_0210200, N-terminal domain

PF3D7_0210200_N

Domain

110

false

This entry represents the N-terminal domain found in Plasmodium falciparum protein PF3D7_0210200. The domain adopts a tetracycline repressor-like fold with a predicted helix-turn-helix structure. The full-length protein is 2588 amino acids and contains predicted coiled-coil regions and multiple disordered regions. The ...

[]

0

[ "PFAM" ]

[ "PF27586" ]

[ "PF3D7_0210200_N" ]

[ 110 ]

1

[]

0

[]

0

[ "PUB00162224" ]

[ "17653272" ]

[ "Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif." ]

[ 2007 ]

1

[]

0

null

[ "Apicomplexa" ]

[ 110 ]

1

[]

0

true

Domain

PF3D7_0210200, N-terminal domain

PF3D7_0210200_N

4

IPR059967

59,967

Probable glycosyl hydrolase, catalytic domain

GH_cat

Domain

199

false

This entry represents probable glycosyl hydrolases found in uncharacterised prokaryotic proteins, including uncharacterized protein SSO3021 ( ). They probably share similar domain composition to BsGH164 as well as to other members of GH42 family. The active site composition is different suggesting that these proteins m...

[]

0

[ "PFAM" ]

[ "PF28584" ]

[ "GH_cat" ]

[ 199 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Calcidiscus leptoporus", "Thermoprotei", "metagenomes" ]

[ 159, 1, 29, 10 ]

4

[]

0

true

Domain

Probable glycosyl hydrolase, catalytic domain

GH_cat

4

IPR059970

59,970

AF_1016/AF_1562-like

AF_1016/AF_1562

Family

34

false

This entry represents the AF_1016 and AF_1562 from Archaeoglobus fulgidus, which are uncharacterised membrane proteins found in sulfate-reducing archaea and bacteria. The proteins are approximately 154 amino acids in length and contain three predicted transmembrane helices, indicating they are integral membrane protein...

[]

0

[ "PFAM" ]

[ "PF27327" ]

[ "AF_1016" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 12, 19, 3 ]

3

[]

0

true

Family

AF_1016/AF_1562-like

AF_1016/AF_1562

6

IPR059971

59,971

SP15, N-terminal domain

SP15_N

Domain

7,965

false

This entry represents the N-terminal domain of 55.5 kDa and 49.5 kDa sporulation proteins (SP15), mostly found in bacteria. These proteins may form a catalyst/regulator pair involved in the temporally controlled sporulation process. The decrease in level of the smaller protein early in sporulation may relieve negative ...

[]

0

[ "PFAM" ]

[ "PF27520" ]

[ "SP15_N" ]

[ 7965 ]

1

[]

0

[]

0

[ "PUB00162300" ]

[ "2123814" ]

[ "Transcriptional and translational features of a sporulation gene of Streptomyces griseus." ]

[ 1990 ]

1

[]

0

null

[ "Bacillati", "Streptomyces phage Raleigh" ]

[ 7964, 1 ]

2

[]

0

true

Domain

SP15, N-terminal domain

SP15_N

3

IPR059972

59,972

Clampless protein, 1 N-terminal domain

Clampless_N

Domain

770

false

This entry represents the N-terminal domain of clampless protein 1 (CLP1) found in basidiomycete fungi, particularly Cryptococcus neoformans. The full-length CLP1 protein is required for developmental progression after cells of opposite mating types fuse and is essential for both dikaryotic filament formation and monok...

[]

0

[ "PFAM" ]

[ "PF28371" ]

[ "Clampless_N" ]

[ 770 ]

1

[]

0

[]

0

[ "PUB00161878" ]

[ "17993575" ]

[ "Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1alpha and Sxi2a." ]

[ 2008 ]

1

[]

0

null

[ "Basidiomycota" ]

[ 770 ]

1

[]

0

true

Domain

Clampless protein, 1 N-terminal domain

Clampless_N

9

IPR059973

59,973

TonB-like, single transmembrane helix

1TM_TonB-like

Domain

2,593

false

This entry represents a single transmembrane helix found at the N-terminal end of uncharacterised proteins mainly from gram-negative bacteria. These proteins usually contain at the C-terminal and this resemble TonB proteins.

[]

0

[ "PFAM" ]

[ "PF28545" ]

[ "1TM_TonB_rel" ]

[ 2593 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Tanacetum cinerariifolium", "metagenomes" ]

[ 2575, 1, 17 ]

3

[]

0

true

Domain

TonB-like, single transmembrane helix

1TM_TonB-like

9

IPR059974

59,974

Ubiquitin carboxyl-terminal hydrolase 47, ubiquitin-like domain

Ubiquitin_USP47_N

Domain

2,071

false

This domain is found at the N-terminal of human Ubiquitin carboxyl-terminal hydrolase 47 (USP47) and similar proteins. USP47 is a ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta, playing a role in base-excision repair. It functions as a regulator of cell growth and ge...

[]

0

[ "PFAM" ]

[ "PF25985" ]

[ "Ubiquitin_USP47_N" ]

[ 2071 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-HSA-5689880", "R-MMU-5689880", "R-XTR-5689880" ]

[ "EC:3.4.19.12", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-5689880", "REACTOME:R-XTR-5689880" ]

4

[]

0

[ "PUB00098845", "PUB00147793" ]

[ "21362556", "19966869" ]

[ "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.", "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival." ]

[ 2011, 2010 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 2071 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 2, 3, 7 ]

5

true

Domain

Ubiquitin carboxyl-terminal hydrolase 47, ubiquitin-like domain

Ubiquitin_USP47_N

6

IPR059975

59,975

Exosporium protein B domain

CsxB

Domain

194

false

This entry represents the CsxB domain found in exosporium proteins of Clostridium species. CsxB is a 151 amino acid protein localised to the exosporium of the spore wall in Clostridium sporogenes [ ]. The protein was identified by mass spectrometry and is part of the spore surface protein complement [ ]. The function o...

[]

0

[ "PFAM" ]

[ "PF27268" ]

[ "CsxB" ]

[ 194 ]

1

[]

0

[]

0

[ "PUB00089400" ]

[ "27375261" ]

[ "Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains." ]

[ 2016 ]

1

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 193, 1 ]

2

[]

0

true

Domain

Exosporium protein B domain

CsxB

6

IPR059976

59,976

TED associated beta-sandwich domain

TEDa_beta-sand

Domain

604

false

This entry represents a β-sandwich domain that is found adjacent to a TED domain . These proteins are likely to function as fibrillar adhesins.

[]

0

[ "PFAM" ]

[ "PF26764" ]

[ "TEDa_beta" ]

[ 604 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "organismal metagenomes" ]

[ 597, 7 ]

2

[]

0

true

Domain

TED associated beta-sandwich domain

TEDa_beta-sand

9

IPR059977

59,977

6-bladed hairpin-propeller protein

6BHPP

Domain

54

false

This entry represents a small family of proteins found in pseudomonadota bacteria and phage proteins. The proteins have a repetitive sequence that folds into a 6-bladed propeller composed of β-hairpin motifs.

[]

0

[ "PFAM" ]

[ "PF27023" ]

[ "6BHPP" ]

[ 54 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Escherichia phage 186", "Pseudomonadati", "metagenomes" ]

[ 1, 48, 5 ]

3

[]

0

true

Domain

6-bladed hairpin-propeller protein

6BHPP

6

IPR059978

59,978

Cephalotoxin, second domain

CTXL_2nd

Domain

31

false

This entry represents the C-terminal domain in Cephalotoxin-like protein. The Cephalotoxin-like protein is a secreted protein found in the coral Acropora millepora and is a component of the organic matrix of the aragonitic skeleton [ ]. The full-length protein contains 473 amino acids and includes coiled-coil regions. ...

[]

0

[ "PFAM" ]

[ "PF27743" ]

[ "CTXL_C" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00088457" ]

[ "23765379" ]

[ "The skeletal proteome of the coral Acropora millepora: the evolution of calcification by co-option and domain shuffling." ]

[ 2013 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 31 ]

1

[]

0

true

Domain

Cephalotoxin, second domain

CTXL_2nd

4

IPR059979

59,979

Aq_aa04-like

Aq_aa04

Family

612

false

This entry represents the Aq_aa04 family of proteins found in the hyperthermophilic bacterium Aquifex aeolicus. The protein is encoded on plasmid ece1 and belongs to the COG0675 functional category. The biological function of this protein family remains unknown.

[]

0

[ "PFAM" ]

[ "PF27142" ]

[ "Aq_aa04" ]

[ 612 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "unclassified sequences" ]

[ 596, 11, 5 ]

3

[]

0

true

Family

Aq_aa04-like

Aq_aa04

8

IPR059980

59,980

CsmB chlorosome envelope protein

CsmB

Family

81

false

This entry represents CsmB and related chlorosome envelope proteins from green sulfur bacteria [ ]. CsmB is a component of the photosynthetic apparatus which may bind the chlorosome to the bacteriochlorophyll a protein monolayer. The proteins are 75-77 amino acids in length and are localised to the chlorosome envelope....

[]

0

[ "PFAM" ]

[ "PF27499" ]

[ "CsmB" ]

[ 81 ]

1

[]

0

[]

0

[ "PUB00161891", "PUB00161892" ]

[ "8824146", "11914082" ]

[ "Characterization of csmB genes, encoding a 7.5-kDa protein of the chlorosome envelope, from the green sulfur bacteria Chlorobium vibrioforme 8327D and Chlorobium tepidum.", "Subcellular localization of chlorosome proteins in Chlorobium tepidum and characterization of three new chlorosome proteins: CsmF, CsmH, an...

[ 1996, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 76, 5 ]

2

[]

0

true

Family

CsmB chlorosome envelope protein

CsmB

5

IPR059981

59,981

ComC, C-terminal domain

ComC_C

Domain

126

false

This entry represents the C-terminal domain of ComC, a competence protein involved in DNA transqformation in Haemophilus influenzae. This domain adopts a ferredoxin-like fold consisting of an α-β sandwich with four-stranded antiparallel β-sheets flanked by two α-helices. The protein is 173 amino acids in length and is ...

[]

0

[ "PFAM" ]

[ "PF27480" ]

[ "ComC_N" ]

[ 126 ]

1

[]

0

[]

0

[ "PUB00161881" ]

[ "1916268" ]

[ "Nucleotide sequence of a cluster of genes involved in the transformation of Haemophilus influenzae Rd." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria" ]

[ 126 ]

1

[]

0

true

Domain

ComC, C-terminal domain

ComC_C

7

IPR059983

59,983

PRR11, first helical domain

PRR11_1st

Domain

532

false

This entry represents the first helical domain of PRR11 (Proline-rich protein 11), found in vertebrates. The specific function of this first helical domain remains to be determined. PRR11 is a cell cycle regulatory protein that plays a critical role in cell cycle progression [ ]. The full-length protein is ubiquitously...

[]

0

[ "PFAM" ]

[ "PF28521" ]

[ "PRR11_1st" ]

[ 532 ]

1

[]

0

[]

0

[ "PUB00162267", "PUB00162268" ]

[ "23246489", "23242552" ]

[ "PRR11 is a novel gene implicated in cell cycle progression and lung cancer.", "Global subcellular characterization of protein degradation using quantitative proteomics." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 532 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 3 ]

3

true

Domain

PRR11, first helical domain

PRR11_1st

6

IPR059984

59,984

PRR11, second helical domain

PRR11_2nd

Domain

587

false

This entry represents the second helical domain of PRR11 (Proline-rich protein 11), found in vertebrates. The specific function of this second helical domain remains to be determined. PRR11 is a cell cycle regulatory protein that plays a critical role in cell cycle progression [ ]. The full-length protein is ubiquitous...

[]

0

[ "PFAM" ]

[ "PF28520" ]

[ "PRR11_2nd" ]

[ 587 ]

1

[]

0

[]

0

[ "PUB00162267", "PUB00162268" ]

[ "23246489", "23242552" ]

[ "PRR11 is a novel gene implicated in cell cycle progression and lung cancer.", "Global subcellular characterization of protein degradation using quantitative proteomics." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 587 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 3 ]

3

true

Domain

PRR11, second helical domain

PRR11_2nd

8

IPR059985

59,985

GerT, N-terminal domain

GerT_N

Domain

119

false

This entry represents the N-terminal domain of GerT, a spore germination protein from Bacillus species [ ]. GerT is involved in spore germination and is probably required at the earliest stage of germination. The C-terminal is localised to the spore coat and adopts an HSP20-like chaperone superfamily structure. GerT pr...

[]

0

[ "PFAM" ]

[ "PF27491" ]

[ "GerT_N" ]

[ 119 ]

1

[]

0

[]

0

[ "PUB00161975" ]

[ "17720779" ]

[ "gerT, a newly discovered germination gene under the control of the sporulation transcription factor sigmaK in Bacillus subtilis." ]

[ 2007 ]

1

[]

0

null

[ "Bacillaceae" ]

[ 119 ]

1

[]

0

true

Domain

GerT, N-terminal domain

GerT_N

1

IPR059986

59,986

DjlB/C, second domain

DjlB_C_2nd

Domain

1,721

false

This entry represents the second domain found in DjlB and DjlC, J domain-containing proteins from Escherichia coli. DjlC is a regulatory HscC co-chaperone [ , ]. These proteins contain an N-terminal J domain characteristic of DnaJ co-chaperones. This second domain shows some resemblance to α-solenoid repeats such as te...

[]

0

[ "PFAM" ]

[ "PF27158" ]

[ "DjlB_C_2nd" ]

[ 1721 ]

1

[]

0

[]

0

[ "PUB00092295", "PUB00092297" ]

[ "12183460", "12054669" ]

[ "Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones.", "Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Trichuris trichiura", "metagenomes" ]

[ 1718, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

DjlB/C, second domain

DjlB_C_2nd

9

IPR059987

59,987

Type II toxin-antitoxin system toxin Rv0299

Rv0299_toxin

Family

66

false

This entry represents the toxin component of a type II toxin-antitoxin system found predominantly in actinobacteria. The prototype protein Rv0299 from Mycobacterium tuberculosis inhibits colony formation when expressed in M. smegmatis [ ]. The toxic effect is neutralised by coexpression with the cognate antitoxin Rv029...

[]

0

[ "PFAM" ]

[ "PF27466" ]

[ "Rv0299_toxin" ]

[ 66 ]

1

[]

0

[]

0

[ "PUB00067485" ]

[ "20011113" ]

[ "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution." ]

[ 2009 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 66 ]

1

[]

0

true

Family

Type II toxin-antitoxin system toxin Rv0299

Rv0299_toxin

3

IPR059988

59,988

YdeH-like

Family

155

false

This entry represents YdeH, an uncharacterised membrane protein from Bacillus subtilis. YdeH is a 148 amino acid multi-pass membrane protein with four predicted transmembrane helices localised to the cell membrane. This entry is found predominantly in Bacillati, particularly within the Bacillales order including Bacill...

[]

0

[ "PFAM" ]

[ "PF27484" ]

[ "YdeH_helical" ]

[ 155 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 155 ]

1

[]

0

true

Family

YdeH-like

9

IPR059989

59,989

SPbeta prophage-derived putative capsid protein YonB

YonB

Family

242

false

This entry represents SPbeta prophage-derived uncharacterised protein YonB. The protein is 338 amino acids in length and is found in Gram-positive bacteria, particularly Bacillus and Paenibacillus species, as well as in bacteriophages. The protein originates from the SPbeta prophage integrated into the Bacillus subtili...

[]

0

[ "PFAM" ]

[ "PF27364" ]

[ "YonB" ]

[ 242 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Candidatus Nitrosomaritimum aestuariumsis", "Tritrichomonas musculus", "Viruses", "ecological metagenomes" ]

[ 153, 2, 1, 84, 2 ]

5

[]

0

true

Family

SPbeta prophage-derived putative capsid protein YonB

YonB

9

IPR059990

59,990

TP_0454, C-terminal domain

TP_0454_C

Domain

43

false

This entry represents the C-terminal domain of TP_0454, an uncharacterised protein from Treponema pallidum. This domain adopts a glycosyltransferase fold, suggesting structural similarity to glycosyltransferases, though no enzymatic activity has been demonstrated. The function of this domain remains to be determined.

[]

0

[ "PFAM" ]

[ "PF27476" ]

[ "TP_0454_C" ]

[ 43 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spirochaetia" ]

[ 43 ]

1

[]

0

true

Domain

TP_0454, C-terminal domain

TP_0454_C

9

IPR059991

59,991

Trichocyst matrix protein T1-F, coiled-coil

T1-F_CC

Domain

2,008

false

This entry represents a coiled-coil domain found in trichocyst matrix proteins from Paramecium species. The domain contains two coiled-coil regions with small helices and is found in structural proteins that crystallise inside the trichocyst matrix [ , , ]. Trichocysts are architecturally complex secretory storage gran...

[]

0

[ "PFAM" ]

[ "PF27870" ]

[ "T1-F" ]

[ 2008 ]

1

[]

0

[]

0

[ "PUB00162308", "PUB00162309", "PUB00162310" ]

[ "8626591", "7579685", "7819344" ]

[ "Cloning and sequence analysis of genes coding for paramecium secretory granule (trichocyst) proteins. A unique protein fold for a family of polypeptides with different primary structures.", "A large multigene family codes for the polypeptides of the crystalline trichocyst matrix in Paramecium.", "Protein proce...

[ 1996, 1995, 1994 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 9, 1999 ]

2

[]

0

true

Domain

Trichocyst matrix protein T1-F, coiled-coil

T1-F_CC

5

IPR059992

59,992

RBM43, C-terminal domain

RBM43_C

Domain

664

false

This entry represents the C-terminal domain of RBM43 (RNA-binding protein 43) found in mammals. RBM43 is an RNA-binding protein that contains an N-terminal RRM domain. The full-length protein has RNA-binding activity and interacts with proteins such as DAZAP2 and IKZF1. This C-terminal domain may contribute to protein-...

[]

0

[ "PFAM" ]

[ "PF28453" ]

[ "RBM43_C" ]

[ 664 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 664 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4 ]

3

true

Domain

RBM43, C-terminal domain

RBM43_C

9

IPR059994

59,994

5' exonuclease Apollo, TRF2-binding domain

Apollo_TRF2-binding

Domain

189

false

Apollo protein, a DNA repair nuclease, is recruited to telomeres by TRF2 where it is associated with the principle components of the shelterin complex [ , , ]. Apollo is a member of the metallo-beta-lactamase family that is required for telomere integrity during S phase; its 5' exonuclease activity is regulated by bind...

[]

0

[ "CDD" ]

[ "cd11662" ]

[ "apollo_TRF2_binding" ]

[ 189 ]

1

[ "EC", "REACTOME" ]

[ "3.5.2.6", "R-HSA-6783310" ]

[ "EC:3.5.2.6", "REACTOME:R-HSA-6783310" ]

2

[ "3bua" ]

1

[ "PUB00050736", "PUB00126206", "PUB00126213", "PUB00128897", "PUB00129042", "PUB00129043" ]

[ "18202258", "18680434", "22244753", "16730176", "20479256", "20551906" ]

[ "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.", "How shelterin protects mammalian telomeres.", "Telomerase and telomere-associated proteins: structural insights into mechanism and evolution.", "Apollo, an Artemis-related nuclease, interacts with TRF2 and pro...

[ 2008, 2008, 2012, 2006, 2010, 2010 ]

6

[]

0

null

[ "Amniota" ]

[ 189 ]

1

[ "Homo sapiens" ]

[ 2 ]

1

true

Domain

5' exonuclease Apollo, TRF2-binding domain

Apollo_TRF2-binding

5

IPR059996

59,996

Ubiquitin-specific protease 28, C-terminal domain

USP28_C

Domain

1,265

false

This entry represents the C-terminal domain of ubiquitin-specific protease USP28, a deubiquitinase (DUB), which shares high similarity with USP25 but varies in cellular function [ , ]. USP28 is known for its tumor-promoting role while USP25 is a regulator of the innate immune system and may play a role in tumorigenesis...

[]

0

[ "CDD" ]

[ "cd20487" ]

[ "USP28_C" ]

[ 1265 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-HSA-5689880", "R-MMU-5689880", "R-RNO-5689880" ]

[ "EC:3.4.19.12", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-5689880", "REACTOME:R-RNO-5689880" ]

4

[]

0

[ "PUB00144227", "PUB00144228", "PUB00144229", "PUB00144230", "PUB00144231", "PUB00144232", "PUB00144233", "PUB00144234" ]

[ "30926243", "30926242", "30910399", "30485491", "30881015", "29415985", "29880484", "29131570" ]

[ "Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.", "Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.", "USP28 regulates deubiquitination of histone H2A and cell proliferation.", "USP28 contributes to the proliferation and metas...

[ 2019, 2019, 2019, 2019, 2019, 2018, 2018, 2017 ]

8

[]

0

null

[ "Gnathostomata" ]

[ 1265 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 6 ]

3

true

Domain

Ubiquitin-specific protease 28, C-terminal domain

USP28_C

4

IPR059997

59,997

Rhipicephalus appendiculatus C5 Inhibitor

C5_RaCI-like

Domain

6

false

This entry represents a conserved domain found in Rhipicephalus appendiculatus C5 inhibitors RaCI1 and RaCI2, Dermacentor andersoni RaCI3, and other homologues. These are novel tick-derived C5 inhibitors that do not share any similarity to previously characterised tick complement inhibitors such as OmCI. Complement C5 ...

[]

0

[ "CDD" ]

[ "cd22951" ]

[ "C5_RaCI-like" ]

[ 6 ]

1

[]

0

[ "5hcc", "5hcd", "5iec" ]

3

[ "PUB00108007", "PUB00109476", "PUB00109477" ]

[ "27018802", "31871188", "31333488" ]

[ "Structural basis for therapeutic inhibition of complement C5.", "An inhibitor of complement C5 provides structural insights into activation.", "Deciphering Biological Processes at the Tick-Host Interface Opens New Strategies for Treatment of Human Diseases." ]

[ 2016, 2020, 2019 ]

3

[]

0

null

[ "Ixodidae" ]

[ 6 ]

1

[]

0

true

Domain

Rhipicephalus appendiculatus C5 Inhibitor

C5_RaCI-like

3

IPR059998

59,998

Spliceosome-associated protein CWC27, C-terminal

CWC27_CTD

Domain

914

false

CWC27, also called antigen NY-CO-10, or probable inactive peptidyl-prolyl cis-trans isomerase CWC27, or PPIase CWC27, or serologically defined colon cancer antigen 10, is part of the spliceosome and plays a role in pre-mRNA splicing. It is a probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity ...

[]

0

[ "CDD" ]

[ "cd22288" ]

[ "CWC27_CTD" ]

[ 914 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[ "5z56", "5z58", "6ff4", "6ff7", "6yvh", "7dvq", "8i0r" ]

7

[ "PUB00089651", "PUB00094506", "PUB00103150", "PUB00138180", "PUB00147313", "PUB00147314", "PUB00147315" ]

[ "20676357", "29360106", "9610721", "12975309", "32329775", "25478830", "28285769" ]

[ "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.", "Structure of the human activated spliceosome in three conformational states.", "Characterization of human colon cancer antigens recognized by autologous antibodies.", "The secreted protein discovery ...

[ 2010, 2018, 1998, 2003, 2020, 2014, 2017 ]

7

[]

0

null

[ "Eukaryota" ]

[ 914 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 1, 5 ]

4

true

Domain

Spliceosome-associated protein CWC27, C-terminal

CWC27_CTD

7

IPR060000

60,000

Effector protein MavE

MavE

Domain

49

false

The Icm/Dot protein translocation apparatus is a type IVb secretion system, highly related to bacterial conjugative DNA transfer systems, and is important in establishing a replication vacuole. A complex of Icm/Dot proteins spans the bacterial envelope, allowing the transfer of proteins from the bacterial cytoplasm acr...

[]

0

[ "CDD" ]

[ "cd21821" ]

[ "MavE" ]

[ 49 ]

1

[]

0

[ "6pir" ]

1

[ "PUB00091363", "PUB00105392", "PUB00146893", "PUB00146894" ]

[ "27986836", "30395255", "22059087", "20880356" ]

[ "Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.", "VFDB 2019: a comparative pathogenomic platform with an interactive web interface.", "Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathog...

[ 2016, 2019, 2011, 2011 ]

4

[]

0

null

[ "Legionellaceae" ]

[ 49 ]

1

[]

0

true

Domain

Effector protein MavE

MavE

6

IPR060001

60,001

SepQ/SsaQ, C-terminal domain

SepQ/SsaQ_C

Domain

794

false

This entry represents the C-terminal domain of several enterobacterial SepQ and SsaQ proteins from enterobacteria. The function of this domain is unclear.

[]

0

[ "PFAM" ]

[ "PF28396" ]

[ "SepQ_C" ]

[ 794 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 794 ]

1

[]

0

true

Domain

SepQ/SsaQ, C-terminal domain

SepQ/SsaQ_C

3

IPR060003

60,003

Diphthamide synthase, N-terminal domain

Diphthami_syn_N

Domain

8,236

false

This entry represents the N-terminal domain of Diphthamide synthase. Diphthamide synthase catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase is evolutionarily conserved in eukaryotes. Diphthamide is a post-translationally modified histidine residue found on archae...

[]

0

[ "PFAM" ]

[ "PF01902" ]

[ "Diphthami_syn_2_N" ]

[ 8236 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.1.14", "PWY-6482", "PWY-7546", "R-BTA-5358493", "R-HSA-5358493", "R-MMU-5358493", "R-RNO-5358493", "R-SCE-5358493", "R-SPO-5358493" ]

[ "EC:6.3.1.14", "METACYC:PWY-6482", "METACYC:PWY-7546", "REACTOME:R-BTA-5358493", "REACTOME:R-HSA-5358493", "REACTOME:R-MMU-5358493", "REACTOME:R-RNO-5358493", "REACTOME:R-SCE-5358493", "REACTOME:R-SPO-5358493" ]

9

[ "2d13", "3rjz", "3rk0", "3rk1" ]

4

[ "PUB00073561" ]

[ "23169644" ]

[ "Chemogenomic approach identified yeast YLR143W as diphthamide synthetase." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 1058, 3080, 4005, 93 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 5, 1, 6, 1, 2, 1, 3, 10, 1, 1, 3 ]

11

true

Domain

Diphthamide synthase, N-terminal domain

Diphthami_syn_N

9

IPR060004

60,004

Aconitase X, first domain

AcnX_1st

Domain

2,937

false

This entry represents the first domain of aconitase X (AcnX, also known as Phosphomevalonate dehydratase large subunit), which corresponds to domain 2 in the canonical four-domain architecture of the aconitase superfamily. This domain contains a central parallel β-sheet linked by α-helices, similar to nucleotide-bindin...

[]

0

[ "PFAM" ]

[ "PF04412" ]

[ "AcnX" ]

[ 2937 ]

1

[ "EC" ]

[ "4.2.1.182" ]

[ "EC:4.2.1.182" ]

1

[ "7cnp", "7cnq", "7cnr", "7cns", "7d2r" ]

5

[ "PUB00088769", "PUB00161781" ]

[ "27929065", "34099860" ]

[ "Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.", "Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily." ]

[ 2016, 2021 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 515, 1752, 580, 90 ]

4

[]

0

true

Domain

Aconitase X, first domain

AcnX_1st

4

IPR060006

60,006

Aconitase X, third domain

AcnX_3rd

Domain

2,824

false

This entry represents the third domain of aconitase X (AcnX, also known as Phosphomevalonate dehydratase large subunit), which corresponds to domain 4 in the canonical four-domain architecture of the aconitase superfamily. This domain has a characteristic β-barrel structure created by eight or nine β-strands with α-hel...

[]

0

[ "PFAM" ]

[ "PF28406" ]

[ "AcnX_3rd" ]

[ 2824 ]

1

[ "EC" ]

[ "4.2.1.182" ]

[ "EC:4.2.1.182" ]

1

[ "7cnp", "7cnq", "7cnr", "7cns", "7d2r" ]

5

[ "PUB00080857", "PUB00088769", "PUB00161781" ]

[ "14568143", "27929065", "34099860" ]

[ "Filling a gap in the central metabolism of archaea: prediction of a novel aconitase by comparative-genomic analysis.", "Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase.", "Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular...

[ 2003, 2016, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 506, 1686, 560, 72 ]

4

[]

0

true

Domain

Aconitase X, third domain

AcnX_3rd

9

IPR060007

60,007

Peptidase family U32, N-terminal domain

Peptidase_U32_N

Domain

31,012

false

This entry represents the N-terminal domain of a group of prokaryotic peptidases. This is a group of peptidases belonging to MEROPS peptidase family U32 (clan U-). They are classified as collagenases as they are present in bacterial collagenases, involved in bacterial infection. For example, Porphyromonas gingivalis Pr...

[]

0

[ "PFAM" ]

[ "PF01136" ]

[ "Peptidase_U32" ]

[ 31012 ]

1

[]

0

[]

0

[ "PUB00002182", "PUB00094342", "PUB00094343", "PUB00094522" ]

[ "1317840", "29069499", "31289180", "31253794" ]

[ "Sequence analysis and characterization of the Porphyromonas gingivalis prtC gene, which expresses a novel collagenase activity.", "Biogenesis and iron-dependency of ribosomal RNA hydroxylation.", "Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway.", "Dua...

[ 1992, 2017, 2019, 2019 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 563, 29728, 54, 169, 498 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

Peptidase family U32, N-terminal domain

Peptidase_U32_N

7

IPR060008

60,008

Flagellar motor switch protein FliM, N-terminal domain

FliM_N

Domain

10,911

false

This entry represents the N-terminal domain of FliM which binds phosphorylated CheY [ ]. The flagellar motor switch in Escherichia coli and Salmonella typhimurium regulates the direction of flagellar rotation and hence controls swimming behaviour [ ]. The switch is a complex apparatus that responds to signals transduce...

[]

0

[ "PFAM" ]

[ "PF02154" ]

[ "FliM" ]

[ 10911 ]

1

[]

0

[ "2hp7", "3soh", "4fhr", "4fq0", "4gc8", "4qrm", "5x0z", "7dm9", "7dma", "8umd", "8umx", "8uox", "8upl", "8vib", "8vid", "8vkq", "8vkr", "8wiw", "8wo5", "8woe", "8xp0", "8xp1", "8yjt", "9n49", "9n4z" ]

25

[ "PUB00001834", "PUB00002083", "PUB00002290", "PUB00004790", "PUB00162465" ]

[ "8224881", "2656645", "8631704", "1631122", "38459206" ]

[ "Gene sequence, overproduction, purification and determination of the wild-type level of the Escherichia coli flagellar switch protein FliG.", "Flagellar switch of Salmonella typhimurium: gene sequences and deduced protein sequences.", "A mutational analysis of the interaction between FliG and FliM, two compone...

[ 1993, 1989, 1996, 1992, 2024 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10747, 14, 150 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar motor switch protein FliM, N-terminal domain

FliM_N

8

IPR060009

60,009

Glycosyltransferase WbsX, N-terminal domain

Glyco_tran_WbsX_N

Domain

3,021

false

Members of this family are found in within O-antigen biosynthesis clusters in Gram-negative bacteria, where they are predicted to function as glycosyltransferases [ , ]. This entry represents the N-terminal domain, which has a TIM-barrel fold. It is found associated with at the C-terminal.

[]

0

[ "PFAM", "CDD" ]

[ "PF14307", "cd11579" ]

[ "Glyco_tran_WbsX", "Glyco_tran_WbsX" ]

[ 3021, 2290 ]

2

[]

0

[]

0

[ "PUB00076771", "PUB00076772" ]

[ "15109730", "16055280" ]

[ "The O-antigen gene cluster of Shigella boydii O11 and functional identification of its wzy gene.", "Structural and genetic characterization of the Shigella boydii type 18 O antigen." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 17, 2807, 133, 3, 61 ]

5

[]

0

true

Domain

Glycosyltransferase WbsX, N-terminal domain

Glyco_tran_WbsX_N

4

IPR060011

60,011

ACT domain, methanobacteriota

ACT_10

Domain

630

false

This entry represents an ACT-like domain found in uncharacterised proteins mainly from methanobacteriota. These domains usually dimerise and bind to small molecules.

[]

0

[ "PFAM" ]

[ "PF26798" ]

[ "ACT_10" ]

[ 630 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 618, 12 ]

2

[]

0

true

Domain

ACT domain, methanobacteriota

ACT_10

2

IPR060012

60,012

Clampless protein 1, C-terminal domain

Clampless_C

Domain

846

false

This entry represents the C-terminal domain of CLP1 (Clampless protein 1), found predominantly in basidiomycete fungi. CLP1 is required for developmental progression after cells of opposite mating types fuse and is essential for dikaryotic filament formation and monokaryotic fruiting in Cryptococcus neoformans. The pro...

[]

0

[ "PFAM" ]

[ "PF28353" ]

[ "CLP1_C" ]

[ 846 ]

1

[]

0

[]

0

[ "PUB00161878" ]

[ "17993575" ]

[ "Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1alpha and Sxi2a." ]

[ 2008 ]

1

[]

0

null

[ "Basidiomycota" ]

[ 846 ]

1

[]

0

true

Domain

Clampless protein 1, C-terminal domain

Clampless_C

9