interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060013 | 60,013 | Ubiquitin-like domain, fungi | UBL_fung | Domain | 870 | false | false | This entry represents a ubiquitin-like domain found in a family of large fungal proteins. This centrally positioned domain shows structural similarity to known ubiquitin-like domains. These proteins also contain a UCH domain ( ) suggesting they may function as deubiquitinating enzymes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26970"
] | [
"UBL"
] | [
870
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"saccharomyceta"
] | [
870
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Ubiquitin-like domain, fungi | Ubiquitin-like domain, fungi | UBL_fung | 2 |
IPR060014 | 60,014 | ACT-like domain, plasmodium | ACT_11 | Domain | 65 | false | false | This entry represents an ACT domain from a family of uncharacterised long proteins found in Plasmodium species. The ACT domain is a small molecule binding module with a characteristic β-α-β-β-α-β fold. Members of this group typically form dimers or higher-order oligomers, with ligand binding often occurring at the doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26946"
] | [
"ACT_11"
] | [
65
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
65
] | 1 | [] | [] | 0 | true | Domain | ACT-like domain, plasmodium | ACT-like domain, plasmodium | ACT_11 | 8 |
IPR060015 | 60,015 | ACT-like domain, proteobacteria | ACT_12 | Domain | 901 | false | false | This entry represents an ACT domain, a small molecule binding module with a characteristic β-α-β-β-α-β fold. Members of this clan typically form dimers or higher-order oligomers, with ligand binding often occurring at the domain interfaces. These domains function as regulatory modules that bind amino acids or other sma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26954"
] | [
"ACT_12"
] | [
901
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Steinernema glaseri",
"hydrothermal vent metagenome"
] | [
897,
1,
3
] | 3 | [] | [] | 0 | true | Domain | ACT-like domain, proteobacteria | ACT-like domain, proteobacteria | ACT_12 | 1 |
IPR060016 | 60,016 | Cornifin 1/Small proline-rich protein 3 | SPRR1/3 | Family | 423 | false | false | This entry represents Cornifin (SPRR1) and SPRR3. SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the st... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02389"
] | [
"Cornifin"
] | [
423
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-6809371",
"R-MMU-6809371"
] | [
"REACTOME:R-HSA-6809371",
"REACTOME:R-MMU-6809371"
] | 2 | [] | 0 | [
"PUB00003652",
"PUB00008086",
"PUB00160394"
] | [
"3133554",
"8325635",
"35234613"
] | [
"Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes.",
"Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.",
"Small p... | [
1988,
1993,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Cytophagales",
"Eukaryota"
] | [
2,
421
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
7
] | 3 | true | Family | Cornifin 1/Small proline-rich protein 3 | Cornifin 1/Small proline-rich protein 3 | SPRR1/3 | 6 |
IPR060017 | 60,017 | Genetic interactor of prohibitins 3, N-terminal domain | GEP3_N | Domain | 837 | false | false | This entry represents the N-terminal domain of the genetic interactor of prohibitins 3 (GEP3) and similar proteins from fungi and plants. The specific function of this N-terminal domain remains to be determined. GEP3 is a mitochondrial protein that may be involved in mitochondrial lipid metabolism. The protein belongs ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28564"
] | [
"GEP3_N"
] | [
837
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066888",
"PUB00071556"
] | [
"19221197",
"19751518"
] | [
"The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria.",
"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharom... | [
2009,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
837
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
3,
1,
2
] | 4 | true | Domain | Genetic interactor of prohibitins 3, N-terminal domain | Genetic interactor of prohibitins 3, N-terminal domain | GEP3_N | 4 |
IPR060018 | 60,018 | Type III secretion system effector XopP-like | XopP-like | Family | 334 | false | false | This entry represents the Type III secretion system effector XopP and related proteins found in proteobacteria. This entry also covers the C-terminal in uncharacterised bacterial proteins. XopP is a highly conserved core-effector protein produced by X. campestris, the causal agent of black rot disease of crucifers such... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28169"
] | [
"XopP"
] | [
334
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106353",
"PUB00106354"
] | [
"25388636",
"35640532"
] | [
"Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice.",
"The host exocyst complex is targeted by a conserved bacterial type-III effector that promotes virulence."
] | [
2014,
2022
] | 2 | [] | [
"IPR049928"
] | 0 | 1 | 0 | [
"Pseudomonadota"
] | [
334
] | 1 | [] | [] | 0 | true | Family | Type III secretion system effector XopP-like | Type III secretion system effector XopP-like | XopP-like | 6 |
IPR060019 | 60,019 | Probable metalloprotease EGY1-like, middle domain | EGY1-like_M | Domain | 2,503 | false | false | This entry represents the middle domain of EGY3 proteins, which are probable zinc metalloproteases localised to the chloroplast membrane. The domain is found predominantly in land plants, with representatives across Magnoliopsida including both rosids and asterids, as well as monocots. It is positioned between the N-te... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27677"
] | [
"EGY3_M"
] | [
2503
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.24.-",
"PWY-8119"
] | [
"EC:3.4.24.-",
"METACYC:PWY-8119"
] | 2 | [] | 0 | [
"PUB00097308",
"PUB00161922",
"PUB00161923"
] | [
"15659096",
"18097640",
"23064408"
] | [
"EGY1 encodes a membrane-associated and ATP-independent metalloprotease that is required for chloroplast development.",
"EGY1 plays a role in regulation of endodermal plastid size and number that are involved in ethylene-dependent gravitropism of light-grown Arabidopsis hypocotyls.",
"Arabidopsis plastid AMOS1/... | [
2005,
2008,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
518,
1985
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
4,
32
] | 3 | true | Domain | Probable metalloprotease EGY1-like, middle domain | Probable metalloprotease EGY1-like, middle domain | EGY1-like_M | 1 |
IPR060020 | 60,020 | TUSC1 | TUSC1 | Family | 290 | false | false | This entry represents TUSC1 proteins from vertebrates. TUSC1 is a tumour suppressor candidate gene 1 protein that is widely expressed at low levels with higher expression in the testis. The protein contains predicted coiled-coil regions that may be involved in protein-protein interactions; it also contains disordered r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28489"
] | [
"TUSC1"
] | [
290
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094141",
"PUB00162356"
] | [
"26897357",
"15208665"
] | [
"Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma.",
"Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer."
] | [
2017,
2004
] | 2 | [
"IPR043450"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
290
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1
] | 3 | true | Family | TUSC1 | TUSC1 | TUSC1 | 2 |
IPR060021 | 60,021 | HIP1R domain | HIP1R_dom | Domain | 3,549 | false | false | This domain is found in human Huntingtin-interacting protein 1-related protein (HIP1R) and related sequences. HIP1R is a component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27524"
] | [
"HIP1R"
] | [
3549
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-432722",
"R-CEL-8856828",
"R-HSA-432722",
"R-HSA-8856828",
"R-HSA-9700645",
"R-HSA-9725370",
"R-MMU-432722",
"R-MMU-8856828"
] | [
"REACTOME:R-CEL-432722",
"REACTOME:R-CEL-8856828",
"REACTOME:R-HSA-432722",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-9700645",
"REACTOME:R-HSA-9725370",
"REACTOME:R-MMU-432722",
"REACTOME:R-MMU-8856828"
] | 8 | [] | 0 | [
"PUB00071983",
"PUB00071988",
"PUB00073184",
"PUB00092689",
"PUB00141938",
"PUB00142086",
"PUB00162017",
"PUB00162018",
"PUB00162019",
"PUB00162020"
] | [
"16027218",
"14732715",
"11889126",
"9147654",
"18790740",
"17928447",
"11007801",
"11532990",
"11577110",
"12163454"
] | [
"Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.",
"HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.",
"HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identific... | [
2005,
2004,
2002,
1997,
2008,
2007,
2000,
2001,
2001,
2002
] | 10 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3549
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
5,
7,
13
] | 5 | true | Domain | HIP1R domain | HIP1R domain | HIP1R_dom | 6 |
IPR060022 | 60,022 | Large ribosomal subunit protein uL15, C-terminal domain | Ribosomal_L15_C | Domain | 355 | false | false | This entry represents the C-terminal in large ribosomal subunit protein uL15 found in epsilonproteobacteria. uL15 is a component of the 50S ribosomal subunit and binds to 23S rRNA. The protein is approximately 133 amino acids and belongs to the universal ribosomal protein uL15 family. It contains an N-terminal disorder... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27056"
] | [
"Ribosomal_L15_epsilon"
] | [
355
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162480"
] | [
"31523176"
] | [
"Ribosomal Protein L15 is involved in Colon Carcinogenesis."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
343,
12
] | 2 | [] | [] | 0 | true | Domain | Large ribosomal subunit protein uL15, C-terminal domain | Large ribosomal subunit protein uL15, C-terminal domain | Ribosomal_L15_C | 1 |
IPR060023 | 60,023 | AlgK, TPR middle domain | TPR_AlgK_middle | Domain | 755 | false | false | This entry represents the middle domain found in AlgK. This domain adopts a TPR-like helical structure and belongs to the SEL superfamily. Members of this entry are found predominantly in Pseudomonas species. The specific function of this TPR domain remains to be determined. AlgK is an alginate biosynthesis protein inv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27483"
] | [
"AlgK_TPR"
] | [
755
] | 1 | [] | [] | [] | 0 | [
"3e4b",
"7ula"
] | 2 | [
"PUB00161785",
"PUB00161786"
] | [
"9043140",
"9457868"
] | [
"A novel gene, algK, from the alginate biosynthesis cluster of Pseudomonas aeruginosa.",
"Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion."
] | [
1997,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
755
] | 1 | [] | [] | 0 | true | Domain | AlgK, TPR middle domain | AlgK, TPR middle domain | TPR_AlgK_middle | 8 |
IPR060024 | 60,024 | TNFRSF19/27, second TNFR Cys domain | TNR19/27_TNFR_Cys_second | Domain | 1,618 | false | false | This entry represents the second TNFR-Cys domain found in tumor necrosis factor receptor superfamily member 19/27 (TNFRSF19/27) and related proteins. This domain is located between the N-terminal extracellular TNFR-Cys repeat region and the large C-terminal cytoplasmic disordered region. TNFRSF19 is a single-pass type ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27736"
] | [
"TNR19_TNFR_Cys_second"
] | [
1618
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034"
] | 2 | [] | 0 | [
"PUB00053654",
"PUB00082499",
"PUB00082527",
"PUB00082529"
] | [
"10809768",
"20501644",
"19543321",
"11039935"
] | [
"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.",
"Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway.",
"XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.... | [
2000,
2010,
2009,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1618
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
4,
5,
6
] | 4 | true | Domain | TNFRSF19/27, second TNFR Cys domain | TNFRSF19/27, second TNFR Cys domain | TNR19/27_TNFR_Cys_second | 5 |
IPR060025 | 60,025 | Calpain15, C-terminal domain | CAPN15_C | Domain | 2,376 | false | false | This domain is found towards the C-terminal end of Calpain-15 from mice, human and Drosophila melanogaster (the fly homologue is known as CalpD). This domain is often found C-terminal to . In mice, loss of Capn15 results in developmental eye anomalies and changes in brain volume [ ]. Similarly, humans with biallelic va... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26741"
] | [
"CalpD_C"
] | [
2376
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.4.22.-",
"R-HSA-1474228",
"R-MMU-1474228"
] | [
"EC:3.4.22.-",
"REACTOME:R-HSA-1474228",
"REACTOME:R-MMU-1474228"
] | 3 | [] | 0 | [
"PUB00161842",
"PUB00162481",
"PUB00162482"
] | [
"1714593",
"32885237",
"33951504"
] | [
"Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster.",
"Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.",
"MRI of Capn15 Knockout Mice and Analysis of Capn... | [
1991,
2020,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2376
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
4,
2,
2,
3
] | 6 | true | Domain | Calpain15, C-terminal domain | Calpain15, C-terminal domain | CAPN15_C | 3 |
IPR060026 | 60,026 | Coiled-coil domain-containing protein 15, C-terminal domain | CCDC15_C | Domain | 752 | false | false | This entry represents the C-terminal domain of coiled-coil domain-containing protein 15 (CCDC15) and similar sequences mainly found in vertebrates. While the full-length protein has established functions in centriole assembly and cilium biogenesis, the specific role of this C-terminal domain remains to be determined [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28517"
] | [
"CCDC15_C"
] | [
752
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161856"
] | [
"37934472"
] | [
"CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
752
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2
] | 4 | true | Domain | Coiled-coil domain-containing protein 15, C-terminal domain | Coiled-coil domain-containing protein 15, C-terminal domain | CCDC15_C | 7 |
IPR060027 | 60,027 | Fanconi anaemia group B protein, C-terminal domain | FANCB_C | Domain | 828 | false | false | This entry represents the C-terminal domain of the Fanconi anaemia group B protein (FANCB). This domain is conserved across vertebrate species. The specific function of this domain remains to be determined. FANCB (also known as FAAP95) is a DNA repair protein required for FANCD2 ubiquitination that is a component of th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28318"
] | [
"FANCB_C"
] | [
828
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 6 | [
"PUB00061939",
"PUB00073779",
"PUB00078482",
"PUB00078483",
"PUB00078485",
"PUB00078487",
"PUB00078488",
"PUB00078489",
"PUB00096995"
] | [
"15502827",
"16357213",
"16720839",
"24910428",
"15611632",
"26123487",
"26658157",
"19264559",
"16116422"
] | [
"X-linked inheritance of Fanconi anemia complementation group B.",
"The Fanconi Anemia/BRCA pathway: new faces in the crowd.",
"Evidence for subcomplexes in the Fanconi anemia pathway.",
"Modularized functions of the Fanconi anemia core complex.",
"New advances in the DNA damage response network of Fanconi ... | [
2004,
2005,
2006,
2014,
2005,
2015,
2015,
2009,
2005
] | 9 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
828
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
5,
2
] | 4 | true | Domain | Fanconi anaemia group B protein, C-terminal domain | Fanconi anaemia group B protein, C-terminal domain | FANCB_C | 1 |
IPR060028 | 60,028 | Style cell-cycle inhibitor 1-like, helix hairpin domain | SCI1-like_hairpin | Domain | 2,403 | false | false | This entry represents a helix hairpin domain found in style cell-cycle inhibitor 1 (SCI1) A and B proteins. The domain structure contains a helix hairpin fold and is found in both plants and fungi. The specific function of this helix hairpin domain remains to be determined. In plants, this domain is usually found at th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27660"
] | [
"SCI1_hairpin"
] | [
2403
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096842",
"PUB00096843",
"PUB00156046"
] | [
"22301969",
"25443839",
"21388377"
] | [
"SCI1, the first member of the tissue-specific inhibitors of CDK (TIC) class, is probably connected to the auxin signaling pathway.",
"SCI1 is a component of the auxin-dependent control of cell proliferation in Arabidopsis upper pistil.",
"Stigma/style cell cycle inhibitor 1 (SCI1), a tissue-specific cell cycle... | [
2012,
2014,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2403
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
3,
1,
6
] | 5 | true | Domain | Style cell-cycle inhibitor 1-like, helix hairpin domain | Style cell-cycle inhibitor 1-like, helix hairpin domain | SCI1-like_hairpin | 8 |
IPR060029 | 60,029 | MutS5, N-terminal domain | MutS5_N | Domain | 3,166 | false | false | This entry represents the N-terminal in MutS5 proteins mostly found in animals, fungi and plants. This domain contains a RNaseH-like fold. MutS5 (or MSH5) is involved in DNA mismatch repair and meiotic recombination processes. It plays a crucial role in facilitating crossovers between homologous chromosomes during meio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27035"
] | [
"MutS5_N"
] | [
3166
] | 1 | [
"REACTOME"
] | [
"R-HSA-912446"
] | [
"REACTOME:R-HSA-912446"
] | 1 | [] | 0 | [
"PUB00088454",
"PUB00162176",
"PUB00162177",
"PUB00162178",
"PUB00162179",
"PUB00162483"
] | [
"18812090",
"18318687",
"18379590",
"23220939",
"11014811",
"34849874"
] | [
"SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers.",
"AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in Arabidopsis thaliana, but is not required for synapsis.",
"The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis.",
"The... | [
2008,
2008,
2008,
2013,
2000,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3166
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Z... | [
6,
1,
4,
24,
7,
1,
2,
4,
1,
7
] | 10 | true | Domain | MutS5, N-terminal domain | MutS5, N-terminal domain | MutS5_N | 8 |
IPR060030 | 60,030 | NEDD4-binding protein 2, UBA domain | UBA_N4BP2 | Domain | 1,331 | false | false | This ubiquitin-associated (UBA) domain is found in human NEDD4-binding protein 2 (N4BP2), which has as 5'-polynucleotide kinase and nicking endonuclease activity and may play a role in DNA repair or recombination [ ]. UBA domains are often involved in ubiquitin binding. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28512"
] | [
"UBA_N4BP2"
] | [
1331
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060369"
] | [
"12730195"
] | [
"Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1331
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
3,
5
] | 5 | true | Domain | NEDD4-binding protein 2, UBA domain | NEDD4-binding protein 2, UBA domain | UBA_N4BP2 | 1 |
IPR060031 | 60,031 | MutS5, C-terminal domain | MutS5_C | Domain | 2,239 | false | false | This entry represents the C-terminal in MutS5 proteins mostly found in animals, fungi and plants. This domain contains an ATP-ase fold. MutS5 (or MSH5) is involved in DNA mismatch repair and meiotic recombination processes. It plays a crucial role in facilitating crossovers between homologous chromosomes during meiosis... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd03281"
] | [
"ABC_MSH5_euk"
] | [
2239
] | 1 | [
"REACTOME"
] | [
"R-HSA-912446"
] | [
"REACTOME:R-HSA-912446"
] | 1 | [] | 0 | [
"PUB00013904",
"PUB00014770",
"PUB00043654",
"PUB00072504",
"PUB00080850",
"PUB00080851",
"PUB00080852",
"PUB00080853",
"PUB00080854",
"PUB00080855",
"PUB00080856",
"PUB00088454",
"PUB00162176",
"PUB00162177",
"PUB00162178",
"PUB00162179",
"PUB00162483"
] | [
"11435397",
"10529352",
"11421270",
"12370001",
"11551790",
"9886914",
"11685233",
"10748248",
"16254912",
"15667317",
"16305368",
"18812090",
"18318687",
"18379590",
"23220939",
"11014811",
"34849874"
] | [
"The human ATP-binding cassette (ABC) transporter superfamily.",
"ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans.",
"The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms.",
"Phy... | [
2001,
1999,
2001,
2002,
2001,
1999,
2001,
2000,
2005,
2005,
2004,
2008,
2008,
2008,
2013,
2000,
2021
] | 17 | [
"IPR000432"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2239
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
7,
1,
24,
4,
1,
2,
4,
1,
6
] | 9 | true | Domain | MutS5, C-terminal domain | MutS5, C-terminal domain | MutS5_C | 6 |
IPR060032 | 60,032 | Uncharacterised conserved protein UCP028175-like | UCP028175-like | Family | 1,009 | false | false | There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members of this entry are mainly found in bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27665"
] | [
"UCP028175"
] | [
1009
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR014540"
] | 0 | 1 | 0 | [
"Bacteria",
"metagenomes"
] | [
1001,
8
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP028175-like | Uncharacterised conserved protein UCP028175-like | UCP028175-like | 9 |
IPR060033 | 60,033 | Female sterile protein K10, C-terminal domain | K10_C | Domain | 717 | false | false | This entry represents the C-terminal domain of the female sterile protein K10 from Drosophila melanogaster and related proteins. The full-length fs(1)K10 protein is a DNA-binding protein that contains a putative helix-turn-helix motif within this C-terminal region. The protein is involved in dorsoventral pattern format... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28493"
] | [
"fs1K10_C"
] | [
717
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161969"
] | [
"10197986"
] | [
"Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"invertebrate metagenome"
] | [
714,
3
] | 2 | [
"Drosophila melanogaster"
] | [
1
] | 1 | true | Domain | Female sterile protein K10, C-terminal domain | Female sterile protein K10, C-terminal domain | K10_C | 9 |
IPR060034 | 60,034 | Sporulation protein YdcC-like | YdcC-like | Family | 1,824 | false | false | This entry represents the Sporulation protein YdcC and related proteins from firmicutes. YdcC is required for efficient sporulation [ ]. The GerS lipoprotein, which binds to the CwlD amidase [ ], is also a member of this family. Both CwlD amidase and its binding partner, the GerS lipoprotein, are essential for the spor... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27667"
] | [
"UCP033729"
] | [
1824
] | 1 | [] | [] | [] | 0 | [
"7rag"
] | 1 | [
"PUB00034578",
"PUB00162484"
] | [
"14523133",
"34570752"
] | [
"Identification of sporulation genes by genome-wide analysis of the sigmaE regulon of Bacillus subtilis.",
"A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation."
] | [
2003,
2021
] | 2 | [] | [
"IPR014584"
] | 0 | 1 | 0 | [
"Bacteria",
"Phytophthora kernoviae 00238/432",
"Stenosarchaea group",
"metagenomes"
] | [
1816,
1,
2,
5
] | 4 | [] | [] | 0 | true | Family | Sporulation protein YdcC-like | Sporulation protein YdcC-like | YdcC-like | 2 |
IPR060035 | 60,035 | HI_1054, N-terminal region | HI_1054_N | Domain | 799 | false | false | This entry represents the N-terminal domain of HI_1054, an uncharacterised protein from Haemophilus influenzae. This N-terminal region does not fold into a compact domain according to structure predictions. This entry also covers the same domain in different bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27159"
] | [
"HI_1054_N"
] | [
799
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Opisthokonta",
"ecological metagenomes"
] | [
773,
2,
16,
8
] | 4 | [] | [] | 0 | true | Domain | HI_1054, N-terminal region | HI_1054, N-terminal region | HI_1054_N | 6 |
IPR060037 | 60,037 | Cadherin-99C, immunoglobulin-like domain | Ig_Cad99C_N | Domain | 765 | false | false | This immunoglobulin-like (Ig-like) domain is found at the N-terminal end of Cadherin-99C from Drosophila melanogaster (Cad99C) and similar proteins mainly from arthropods and nematodes. Cad99C functions in epithelial morphogenesis and the intestine epithelial immune response. It is essential for female fertility and to... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28393"
] | [
"Ig_Cad99C_N"
] | [
765
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162059",
"PUB00162060",
"PUB00162061",
"PUB00162062",
"PUB00162063",
"PUB00162064",
"PUB00162065",
"PUB00162066",
"PUB00162067"
] | [
"16260500",
"16507588",
"24718992",
"25236597",
"25639794",
"20736288",
"20098718",
"23698350",
"25373898"
] | [
"Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli.",
"Cadherin Cad99C is required for normal microvilli morphology in Drosophila follicle cells.",
"Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation.",... | [
2005,
2006,
2014,
2014,
2015,
2010,
2010,
2013,
2014
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
765
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
2,
4
] | 2 | true | Domain | Cadherin-99C, immunoglobulin-like domain | Cadherin-99C, immunoglobulin-like domain | Ig_Cad99C_N | 1 |
IPR060039 | 60,039 | Sphingomyelinase D/Phospholipase D | SMase_D/PLipase_D | Family | 510 | false | false | This family of enzymes includes sphingomyelinase D mainly from ascomycota and phospholipase D from actinobacteria and fungi, Phospholipase D displays sphingomyelinase and haemolytic activity. In Corynebacterium pseudotuberculosis and other pathogens, the enzyme acts as a virulence factor affecting bacterial disseminati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27711"
] | [
"SMase_D_PLipase_D"
] | [
510
] | 1 | [
"EC"
] | [
"3.1.4.41"
] | [
"EC:3.1.4.41"
] | 1 | [
"9yd8"
] | 1 | [
"PUB00073648",
"PUB00073649",
"PUB00073650"
] | [
"7934899",
"7737503",
"8406819"
] | [
"Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis.",
"Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology.",
"Arcanobacterium haemolyticum phospholipase D is... | [
1994,
1995,
1993
] | 3 | [] | [
"IPR016674"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota"
] | [
157,
353
] | 2 | [] | [] | 0 | true | Family | Sphingomyelinase D/Phospholipase D | Sphingomyelinase D/Phospholipase D | SMase_D/PLipase_D | 1 |
IPR060040 | 60,040 | Uncharacterized protein YegR | YegR | Family | 193 | false | false | This entry represents the uncharacterised protein YegR from E.coli and related gammaproteobacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27694"
] | [
"UCP007004"
] | [
193
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"human gut metagenome"
] | [
191,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Uncharacterized protein YegR | Uncharacterized protein YegR | YegR | 2 |
IPR060041 | 60,041 | Exportin-6, C-terminal domain | TPR_XPO6_C | Domain | 1,976 | false | false | This entry represents the TPR-like C-terminal domain in human Exportin-6 (XPO6). XPO6 is a nuclear export receptor that transfers profilin-actin complexes from the nucleus to the cytoplasm [ ]. Reduced interaction of Exp6 and RanGTP has been linked to cellular senescence [ ]. It mediates the nuclear export of actin and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26714"
] | [
"TPR_XPO6_C"
] | [
1976
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090421",
"PUB00090422",
"PUB00162351",
"PUB00162352"
] | [
"14592989",
"21195711",
"22323606",
"16489345"
] | [
"Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.",
"Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.",
"Active maintenance of nuclear actin by importin 9 supports tra... | [
2003,
2011,
2012,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1976
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
5,
5,
5
] | 5 | true | Domain | Exportin-6, C-terminal domain | Exportin-6, C-terminal domain | TPR_XPO6_C | 1 |
IPR060042 | 60,042 | Aq_678-like | Aq_678-like | Family | 258 | false | false | This entry represents Uncharacterized protein aq_678 from Aquifex aeolicus and similar sequences from proteobacteria. Aq_678, which is 192 amino acids, contains a coiled coil region at residues 53-111. Its function remains to be determined. Many members of this entry have a lipid attachment site. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27284"
] | [
"Aq_678"
] | [
258
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Hevea brasiliensis",
"Pseudomonadati"
] | [
1,
257
] | 2 | [] | [] | 0 | true | Family | Aq_678-like | Aq_678-like | Aq_678-like | 3 |
IPR060044 | 60,044 | Inner membrane YidI | YidI | Family | 269 | false | false | This group represents an inner membrane protein YidI and related proteobacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27700"
] | [
"Uncharacterised_IM_YidI"
] | [
269
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR016512"
] | 0 | 1 | 0 | [
"Ecdysozoa",
"Pseudomonadati",
"hydrothermal vent metagenome"
] | [
2,
266,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Inner membrane YidI | Inner membrane YidI | YidI | 4 |
IPR060045 | 60,045 | Uncharacterised conserved protein UCP007778-like | UCP007778-like | Family | 714 | false | false | This group represents uncharacterised fungal proteins, such as YGR117C from S.cerevisiae, that contain a β-propeller fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27702"
] | [
"UCP007778"
] | [
714
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR016520"
] | 0 | 1 | 0 | [
"Eukaryota",
"Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)"
] | [
713,
1
] | 2 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Uncharacterised conserved protein UCP007778-like | Uncharacterised conserved protein UCP007778-like | UCP007778-like | 5 |
IPR060046 | 60,046 | DNA import protein CedA/CedA1 domain | CedA/CedA1_dom | Domain | 182 | false | false | This entry represents a domain that covers the whole length of the DNA import protein CedA1 ( ) from Sulfolobus acidocaldarius, a component of the Ced (Crenarchaeal system for exchange of DNA) system found in Archaea. The protein is 78 amino acids in length with a molecular weight of approximately 8.6 kDa and contains ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27251"
] | [
"CedA1"
] | [
182
] | 1 | [] | [] | [] | 0 | [
"8dfu"
] | 1 | [
"PUB00106133"
] | [
"26884154"
] | [
"The archaeal Ced system imports DNA."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
182
] | 1 | [] | [] | 0 | true | Domain | DNA import protein CedA/CedA1 domain | DNA import protein CedA/CedA1 domain | CedA/CedA1_dom | 8 |
IPR060047 | 60,047 | Probable rhamnogalacturonate lyase B-like, middle domain | RglB-like_middle | Domain | 981 | false | false | This entry represents a middle domain found in rhamnogalacturonate lyase enzymes, including rhamnogalacturonate lyase B and rhamnogalacturonate lyase C. This domain can be found next to the N-terminal or at the C-terminal in . Probable rhamnogalacturonate lyase B and C secreted enzymes catalyse the eliminative cleavage... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28395"
] | [
"RglB_C"
] | [
981
] | 1 | [
"EC",
"METACYC"
] | [
"4.2.2.23",
"PWY-6771"
] | [
"EC:4.2.2.23",
"METACYC:PWY-6771"
] | 2 | [] | 0 | [
"PUB00079200"
] | [
"16844780"
] | [
"Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Dikarya"
] | [
15,
966
] | 2 | [] | [] | 0 | true | Domain | Probable rhamnogalacturonate lyase B-like, middle domain | Probable rhamnogalacturonate lyase B-like, middle domain | RglB-like_middle | 8 |
IPR060048 | 60,048 | Probable KH-domain | KH_13 | Domain | 988 | false | false | This entry represents a likely RNA-binding KH domain found in uncharacterised fungal proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26657"
] | [
"KH_13"
] | [
988
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
988
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Probable KH-domain | Probable KH-domain | KH_13 | 9 |
IPR060049 | 60,049 | MADD, penultimate PH-like domain | PH_MADD_pen | Domain | 5,503 | false | false | This entry represents the penultimate C-terminal pleckstrin homology (PH)-like domain found in animal MAP kinase-activating death domain (MADD) proteins. Although towards the C terminus of these proteins it is found towards the N terminus of . MADD proteins function as adaptor proteins in cell death and MAP kinase sign... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26658"
] | [
"PH_MADD_pen"
] | [
5503
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8876198",
"R-DME-8876198",
"R-HSA-5357905",
"R-HSA-8876198",
"R-MMU-5357905",
"R-MMU-8876198",
"R-RNO-5357905",
"R-RNO-8876198"
] | [
"REACTOME:R-CEL-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-8876198",
"REACTOME:R-RNO-5357905",
"REACTOME:R-RNO-8876198"
] | 8 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
5503
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
50,
11,
10,
13,
8
] | 6 | true | Domain | MADD, penultimate PH-like domain | MADD, penultimate PH-like domain | PH_MADD_pen | 4 |
IPR060050 | 60,050 | YjiT, second domain | YjiT_2nd | Domain | 420 | false | false | This entry represents the second domain of YjiT, an uncharacterised protein from Escherichia coli, and similar bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27205"
] | [
"YjiT_2nd"
] | [
420
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Symbiodinium pilosum",
"mine drainage metagenome"
] | [
417,
1,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YjiT, second domain | YjiT, second domain | YjiT_2nd | 2 |
IPR060051 | 60,051 | TP_0214-like | TP_0214-like | Family | 238 | false | false | This entry represents a group of uncharacterised bacterial sequences, including TP_0214, a small protein from Treponema pallidum. TP_0214 is a 65-amino-acid protein (gene TP_0214) from the syphilis spirochete. It is predicted to adopt a zinc finger-like structure, which typically involves coordination of zinc ions by c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27208"
] | [
"TP_0214"
] | [
238
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
236,
2
] | 2 | [] | [] | 0 | true | Family | TP_0214-like | TP_0214-like | TP_0214-like | 9 |
IPR060052 | 60,052 | Synaptosomal-associated protein 47, PH-like domain | PH_SNAP47_2nd | Domain | 1,088 | false | false | This entry represents the second PH-like domain found in synaptosomal-associated protein 47 (SNAP-47). SNAP47 is a SNARE protein that may play a role in intracellular membrane fusion and is involved in synaptic vesicle priming and exocytosis. The protein associates with the BLOC-1 complex and forms complexes with VAMP2... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28207"
] | [
"PH_SNAP47_2nd"
] | [
1088
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00134575"
] | [
"16621800"
] | [
"Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1088
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
11,
2,
2
] | 4 | true | Domain | Synaptosomal-associated protein 47, PH-like domain | Synaptosomal-associated protein 47, PH-like domain | PH_SNAP47_2nd | 4 |
IPR060053 | 60,053 | Dual oxidase, PH domain | PH_DUOX | Domain | 2,494 | false | false | This entry represents a PH-like domain found in dual oxidase animal proteins. This group of proteins is involved in generating hydrogen peroxide, which is crucial for the activity of thyroid peroxidase and lactoperoxidase, playing a significant role in thyroid hormone synthesis and antimicrobial defence at mucosal surf... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26659"
] | [
"PH_DUOX"
] | [
2494
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.11.1.-",
"1.6.3.1",
"PWY-5292",
"R-CEL-209968",
"R-CFA-209968",
"R-DME-209968",
"R-HSA-209968",
"R-MMU-209968",
"R-RNO-209968",
"R-SSC-209968"
] | [
"EC:1.11.1.-",
"EC:1.6.3.1",
"METACYC:PWY-5292",
"REACTOME:R-CEL-209968",
"REACTOME:R-CFA-209968",
"REACTOME:R-DME-209968",
"REACTOME:R-HSA-209968",
"REACTOME:R-MMU-209968",
"REACTOME:R-RNO-209968",
"REACTOME:R-SSC-209968"
] | 10 | [
"6wxr",
"6wxu",
"6wxv",
"7d3e",
"7d3f"
] | 5 | [
"PUB00163203",
"PUB00163204",
"PUB00163205",
"PUB00163206",
"PUB00163207"
] | [
"10806195",
"11514595",
"15972824",
"19406744",
"23028364"
] | [
"Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.",
"Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.",
"Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generatin... | [
2000,
2001,
2005,
2009,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2494
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
12,
3,
6,
4,
8
] | 6 | true | Domain | Dual oxidase, PH domain | Dual oxidase, PH domain | PH_DUOX | 2 |
IPR060055 | 60,055 | Phospholipase D C, PH domain-like | PldC_PH | Domain | 7 | false | false | This entry represents a PH domain found in a Phospholipase D C from Dictyostelium discoideum (PldC) and related proteins that also have a phospholipase D domain. PldC plays a role in cell growth, hydrolyses membrane phospholipids and is involved in the inhibition of actin-based motility and endocytosis. Its inhibition ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26662"
] | [
"PH_42"
] | [
7
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-1483166",
"R-DDI-2029485",
"R-DDI-6798695",
"R-DDI-9013149",
"R-DDI-9013404",
"R-DDI-9013408"
] | [
"REACTOME:R-DDI-1483166",
"REACTOME:R-DDI-2029485",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-9013149",
"REACTOME:R-DDI-9013404",
"REACTOME:R-DDI-9013408"
] | 6 | [] | 0 | [
"PUB00163200",
"PUB00163201",
"PUB00163202"
] | [
"15769249",
"6498208",
"8394342"
] | [
"Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium.",
"Comparison of the hydrolysis of phosphatidylethanolamine and phosphatidyl(N-acyl)ethanolamine in Dictyostelium discoideum amoebae.",
"Developmentally regulated changes in 1,2-diacylglycerol in Dictyosteli... | [
2005,
1984,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Dictyostelia"
] | [
7
] | 1 | [] | [] | 0 | true | Domain | Phospholipase D C, PH domain-like | Phospholipase D C, PH domain-like | PldC_PH | 6 |
IPR060056 | 60,056 | DUF1631, C-terminal tudor domain | DUF1631_C | Domain | 3,262 | false | false | This entry represents the C-terminal domain found in DUF1631 family proteins. This domain structurally resembles a tudor domain. The members of this family are sequences derived from a group of hypothetical proteins expressed by certain beta and gammaproteobacterial species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26670"
] | [
"DUF1631_C"
] | [
3262
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3198,
6,
58
] | 3 | [] | [] | 0 | true | Domain | DUF1631, C-terminal tudor domain | DUF1631, C-terminal tudor domain | DUF1631_C | 3 |
IPR060057 | 60,057 | Epidermal growth factor-like protein, EGF domain | EGF_EGF-like | Domain | 997 | false | false | This Cysteine rich repeat is found in Epidermal growth factor-like protein from Holotrichia diomphalia (EGF-like) and related insect proteins. EGF-like binds to lipopolysaccharides (LPS) present on the cell walls of Gram-negative bacteria, behaving as a pattern recognition receptor (PRR) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26673"
] | [
"EGF_C_tripleX"
] | [
997
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00163199"
] | [
"16849495"
] | [
"A novel 40-kDa protein containing six repeats of an epidermal growth factor-like domain functions as a pattern recognition protein for lipopolysaccharide."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
997
] | 1 | [
"Drosophila melanogaster"
] | [
34
] | 1 | true | Domain | Epidermal growth factor-like protein, EGF domain | Epidermal growth factor-like protein, EGF domain | EGF_EGF-like | 4 |
IPR060058 | 60,058 | Prophage endopeptidase tail domain | Prophage_tail_N2 | Domain | 1,118 | false | false | This entry represents a domain found in a group of prophage tail proteins that are probably acting as endopeptidases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26674"
] | [
"Prophage_tail_N2"
] | [
1118
] | 1 | [] | [] | [] | 0 | [
"3gs9",
"9j1k"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
1034,
82,
2
] | 3 | [] | [] | 0 | true | Domain | Prophage endopeptidase tail domain | Prophage endopeptidase tail domain | Prophage_tail_N2 | 9 |
IPR060059 | 60,059 | Probable ATP-binding protein BrxC, seventh domain | BREX_BrxC_7th | Domain | 195 | false | false | This entry represents the seventh domain of the BrxC protein from the BREX (bacteriophage exclusion) system from Bacillus cereus. This domain contains an α-helical fold, and it is next to the C-terminal domain. This entry is found in bacillota. BrxC is a P-loop-containing, probable ATPase associated with type 1 BREX (b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27212"
] | [
"BrxC_7th"
] | [
195
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093365"
] | [
"25452498"
] | [
"BREX is a novel phage resistance system widespread in microbial genomes."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriaceae",
"Siphoviridae sp. ctSA812",
"bioreactor metagenome"
] | [
187,
4,
1,
3
] | 4 | [] | [] | 0 | true | Domain | Probable ATP-binding protein BrxC, seventh domain | Probable ATP-binding protein BrxC, seventh domain | BREX_BrxC_7th | 2 |
IPR060060 | 60,060 | AF_0155, Rossmann-like domain | Rossmann-like_AF_0155 | Domain | 2,007 | false | false | This entry represents a domain that covers most of the length of the sequence in AF_0155, an uncharacterised protein from Archaeoglobus fulgidus. This domain adopts a Rossmann-like fold, which is typically associated with nucleotide binding and is commonly found in dehydrogenases and other enzymes that utilise NAD or N... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27217"
] | [
"AF_0155"
] | [
2007
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
159,
1754,
3,
91
] | 4 | [] | [] | 0 | true | Domain | AF_0155, Rossmann-like domain | AF_0155, Rossmann-like domain | Rossmann-like_AF_0155 | 8 |
IPR060061 | 60,061 | Agl23 flippase-associated protein-like, C-terminal domain | Agl23-like_C | Domain | 376 | false | false | This entry represents the C-terminal domain of Agl23 from the extremely halophilic archaea Haloarcula hispanica (also known as Dpm4, ( ), a putative flippase-associated protein involved in hexose-dolichol phosphate (hexose-DolP) translocation across membranes. Agl23 (also known as HAH_2016) is a multi-spanning membrane... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26681"
] | [
"Agl23_C"
] | [
376
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00099992"
] | [
"32706435"
] | [
"Agl22 and Agl23 are involved in the synthesis and utilization of the lipid-linked intermediates in the glycosylation pathways of the halophilic archaeaon Haloarcula hispanica."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
376
] | 1 | [] | [] | 0 | true | Domain | Agl23 flippase-associated protein-like, C-terminal domain | Agl23 flippase-associated protein-like, C-terminal domain | Agl23-like_C | 6 |
IPR060062 | 60,062 | DUF8230, N-terminal | DUF8230_N | Domain | 384 | false | false | This entry represents the N-terminal domain of aa group of uncharacterised putative enzymes mainly found in archaea. It shows structural similarity to the N-terminal domain of enolase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26684"
] | [
"DUF8230_N"
] | [
384
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"freshwater metagenome"
] | [
33,
345,
6
] | 3 | [] | [] | 0 | true | Domain | DUF8230, N-terminal | DUF8230, N-terminal | DUF8230_N | 7 |
IPR060063 | 60,063 | DUF8230, C-terminal | DUF8230_C | Domain | 386 | false | false | This entry represents the C-terminal domain of a group of uncharacterised putative enzymes mainly found in archaea. It shows structural similarity to the C-terminal domain of enolase and has a TIM barrel fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26685"
] | [
"DUF8230_C"
] | [
386
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"freshwater metagenome"
] | [
36,
342,
8
] | 3 | [] | [] | 0 | true | Domain | DUF8230, C-terminal | DUF8230, C-terminal | DUF8230_C | 1 |
IPR060064 | 60,064 | MJ0043, C-terminal domain | MJ0043_C | Domain | 1,932 | false | false | This entry represents the C-terminal domain of MJ0043, an uncharacterised protein from Methanocaldococcus jannaschii. This domain represents the second part of the mature protein (residues 521-785) after intein removal. The protein is found in methanogenic archaea and is annotated as arCOG04881. The specific function o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27218"
] | [
"MJ0043_C"
] | [
1932
] | 1 | [] | [] | [] | 0 | [
"5zb8",
"7k30",
"7k31",
"7k32",
"7k33"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
298,
1581,
53
] | 3 | [] | [] | 0 | true | Domain | MJ0043, C-terminal domain | MJ0043, C-terminal domain | MJ0043_C | 2 |
IPR060065 | 60,065 | DOCK6-11, TPR domain | TPR_DOCK6-11 | Domain | 15,093 | false | false | This is a domain consisting of tetratricopeptide (TPR)-like repeats found in human Dedicator of cytokinesis protein 6-11 (DOCK6-11) and related proteins. They are guanine nucleotide-exchange factors (GEF) that activate proteins by exchanging bound GDP for free GTP [ , , , ]. DOCK7 activates Rac1 and Rac3 Rho small GTPa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28208"
] | [
"TPR_DOCK9"
] | [
15093
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8875555",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013409",
"R-HSA-9013423",
"R-HSA-983231",
"R-MMU-8875555",
"R-MMU-9013148",
"R-MMU-9013149",
"R-MMU-9013404",
"R-MMU-9013409",
"R-MMU-9013423",
"R-MMU-983231"
] | [
"REACTOME:R-HSA-8875555",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013409",
"REACTOME:R-HSA-9013423",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-8875555",
"REACTOME:R-MMU-9013148",
"REACTOME:R-MMU-9013149",
"REACTOME:R-MMU-9013404",
"REACTOME... | 14 | [] | 0 | [
"PUB00061819",
"PUB00062239",
"PUB00062242",
"PUB00128691",
"PUB00129744",
"PUB00145319",
"PUB00162343",
"PUB00162344",
"PUB00162345",
"PUB00162346"
] | [
"16982419",
"17196961",
"12172552",
"16968698",
"22494997",
"29467281",
"37342957",
"25851601",
"25729399",
"27502165"
] | [
"The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.",
"Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.",
"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho prot... | [
2006,
2007,
2002,
2006,
2012,
2018,
2023,
2015,
2015,
2016
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
15093
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
4,
96,
10,
31,
30,
2,
38,
69
] | 9 | true | Domain | DOCK6-11, TPR domain | DOCK6-11, TPR domain | TPR_DOCK6-11 | 1 |
IPR060066 | 60,066 | Adenylate cyclase, class-I, third domain | Adenylate_cycl_3rd | Domain | 3,201 | false | false | This entry represents the third domain of class-I adenylate cyclases. It is predicted to contain anti-parallel β-sheets and α-helices. Adenylate cyclase is the enzyme responsible for the synthesis of cAMP from ATP. On the basis of sequence similarity, it has been proposed that there are three different classes of adeny... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26690"
] | [
"Adenylate_cycl_3rd"
] | [
3201
] | 1 | [
"EC"
] | [
"4.6.1.1"
] | [
"EC:4.6.1.1"
] | 1 | [] | 0 | [
"PUB00000015",
"PUB00004943"
] | [
"8418825",
"7863008"
] | [
"Phylogeny of adenylyl cyclases.",
"Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3180,
2,
19
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Adenylate cyclase, class-I, third domain | Adenylate cyclase, class-I, third domain | Adenylate_cycl_3rd | 4 |
IPR060067 | 60,067 | Outer dense fiber protein 2, N-terminal domain | ODF2_N | Domain | 1,912 | false | false | This entry represents the N-terminal in ODF2 proteins, also known as cenexin. ODF2 is a major component of the outer dense fibres in mammalian sperm tails and plays a crucial role in cytoskeletal organisation. The protein exhibits self-association properties, forming fibrillar structures that are intimately linked to t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27578"
] | [
"ODF2_N"
] | [
1912
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [] | 0 | [
"PUB00060017",
"PUB00060018",
"PUB00162210"
] | [
"15852003",
"9740324",
"15340007"
] | [
"Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia.",
"Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail.",
"Outer dense fibre protein 2 (ODF2) is a self-intera... | [
2005,
1998,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pyrolobus fumarii (strain DSM 11204 / 1A)"
] | [
1911,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
12,
11,
13
] | 4 | true | Domain | Outer dense fiber protein 2, N-terminal domain | Outer dense fiber protein 2, N-terminal domain | ODF2_N | 5 |
IPR060068 | 60,068 | Adenylate cyclase, class-I, fourth domain | Adenylate_cycl_4th | Domain | 3,224 | false | false | This entry represents the fourth domain of class-I adenylate cyclases. It is predicted to contain anti-parallel β-sheets and α-helices. Adenylate cyclase is the enzyme responsible for the synthesis of cAMP from ATP. On the basis of sequence similarity, it has been proposed that there are three different classes of aden... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26691"
] | [
"Adenylate_cycl_4th"
] | [
3224
] | 1 | [
"EC"
] | [
"4.6.1.1"
] | [
"EC:4.6.1.1"
] | 1 | [] | 0 | [
"PUB00000015",
"PUB00004943"
] | [
"8418825",
"7863008"
] | [
"Phylogeny of adenylyl cyclases.",
"Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3201,
2,
21
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Adenylate cyclase, class-I, fourth domain | Adenylate cyclase, class-I, fourth domain | Adenylate_cycl_4th | 3 |
IPR060069 | 60,069 | Adenylate cyclase, class-I, C-terminal | Adenylate_cycl_C | Domain | 2,163 | false | false | This entry represents the C-terminal domain of class-I adenylate cyclases. It is predicted to contain anti-parallel β-sheets and an α-helix. Adenylate cyclase is the enzyme responsible for the synthesis of cAMP from ATP. On the basis of sequence similarity, it has been proposed that there are three different classes of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26693"
] | [
"Adenylate_cycl_C"
] | [
2163
] | 1 | [
"EC"
] | [
"4.6.1.1"
] | [
"EC:4.6.1.1"
] | 1 | [] | 0 | [
"PUB00000015",
"PUB00004943"
] | [
"8418825",
"7863008"
] | [
"Phylogeny of adenylyl cyclases.",
"Adenylyl cyclases: a heterogeneous class of ATP-utilizing enzymes."
] | [
1993,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Oryza sativa subsp. indica",
"metagenomes"
] | [
2157,
1,
5
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Adenylate cyclase, class-I, C-terminal | Adenylate cyclase, class-I, C-terminal | Adenylate_cycl_C | 5 |
IPR060070 | 60,070 | Competence protein ComGC, C-terminal domain | ComGC_C | Domain | 2,458 | false | false | This entry represents the C-terminal region of Competence protein ComGC from Streptococcus pneumoniae and similar proteins mainly from firmicutes. ComGC, also known as Major pilin ComGC, is a major component of the type IV-like pilus (T4P) that is required for transformation [ , ]. This domain is found associated with ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26697"
] | [
"ComGC_C"
] | [
2458
] | 1 | [] | [] | [] | 0 | [
"5nca",
"6txt",
"6y1h"
] | 3 | [
"PUB00045992",
"PUB00101164",
"PUB00106112",
"PUB00160957",
"PUB00160958",
"PUB00161883"
] | [
"9422590",
"23825953",
"35004361",
"24550320",
"28659339",
"33754381"
] | [
"All seven comG open reading frames are required for DNA binding during transformation of competent Bacillus subtilis.",
"A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae.",
"The Role of Minor Pilins in Assembly and Function of the Competence Pilus of <i>Streptococc... | [
1998,
2013,
2021,
2014,
2017,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes",
"unclassified Caudoviricetes"
] | [
2449,
6,
3
] | 3 | [] | [] | 0 | true | Domain | Competence protein ComGC, C-terminal domain | Competence protein ComGC, C-terminal domain | ComGC_C | 1 |
IPR060071 | 60,071 | IPGAL1-like, C-terminal | IPGAL1_C | Domain | 3,589 | false | false | This domain is found at the C-terminal end of INCREASED PETAL GROWTH ANISOTROPY 1-like protein 1 from Arabidopsis thaliana (IPGAL1) and similar plant sequences. IPGAL1 is a microtubule-associated protein probably involved in the regulation of microtubule organisation [ ]. This domain is predicted to form a five-helical... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26700"
] | [
"IPGAL1_C"
] | [
3589
] | 1 | [] | [] | [] | 0 | [
"8waf",
"8wag"
] | 2 | [
"PUB00088586",
"PUB00090773",
"PUB00151546",
"PUB00151547",
"PUB00151548",
"PUB00162105",
"PUB00162106"
] | [
"18715957",
"18193273",
"31198941",
"31623377",
"35975703",
"12490952",
"14615600"
] | [
"Chloroplast outer envelope protein CHUP1 is essential for chloroplast anchorage to the plasma membrane and chloroplast movement.",
"The chloroplast outer membrane protein CHUP1 interacts with actin and profilin.",
"Arabidopsis IPGA1 is a microtubule-associated protein essential for cell expansion during petal ... | [
2008,
2008,
2019,
2019,
2022,
2002,
2003
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3589
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
23,
32
] | 3 | true | Domain | IPGAL1-like, C-terminal | IPGAL1-like, C-terminal | IPGAL1_C | 6 |
IPR060072 | 60,072 | Rho GTPase-activating protein 18-like, N-terminal SAM domain | SAM_ARHGAP18_N | Domain | 3,188 | false | false | This SAM-like domain is found at the N-terminal end of human Rho GTPase-activating protein 18/28 (ARHGAP18/28) and similar proteins mainly found in animals. ARHGAP18 suppresses F-actin polymerisation by inhibiting Rho [ ]. It plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26701"
] | [
"SAM_ARHGAP18_N"
] | [
3188
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-8980692",
"R-DME-9013148",
"R-HSA-8980692",
"R-HSA-9013106",
"R-MMU-8980692",
"R-MMU-9013106"
] | [
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013148",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013106"
] | 6 | [] | 0 | [
"PUB00160465",
"PUB00160466",
"PUB00162287"
] | [
"21865595",
"25778702",
"23468526"
] | [
"ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.",
"YAP is essential for tissue tension to ensure vertebrate 3D body shape.",
"Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin."
] | [
2011,
2015,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Candidatus Alectryocaccomicrobium excrementavium",
"Halobellus ruber",
"Opisthokonta"
] | [
1,
1,
3186
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
2,
4,
6,
7
] | 5 | true | Domain | Rho GTPase-activating protein 18-like, N-terminal SAM domain | Rho GTPase-activating protein 18-like, N-terminal SAM domain | SAM_ARHGAP18_N | 9 |
IPR060073 | 60,073 | DUF272, C-terminal domain | DUF272_C | Domain | 141 | false | false | This domain is mainly found in proteins from Caenorhabditis species and has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26704"
] | [
"DUF272_C"
] | [
141
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
141
] | 1 | [
"Caenorhabditis elegans"
] | [
12
] | 1 | true | Domain | DUF272, C-terminal domain | DUF272, C-terminal domain | DUF272_C | 7 |
IPR060074 | 60,074 | EVI5-like domain | EVI5-like_dom | Domain | 3,166 | false | false | This entry represents a domain found in human Ecotropic viral integration site 5 protein homolog (EVI5), the uncharacterised protein DDB_G0272194 from Dictyostelium discoideum, and similar sequences predominantly found in vertebrates that also have a Rab-GAP-TBC domain ( ). EVI5 functions as a regulator of cell cycle p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27580"
] | [
"DDB_G0272194"
] | [
3166
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162485"
] | [
"16439210"
] | [
"The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3166
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
26,
9,
7,
12
] | 4 | true | Domain | EVI5-like domain | EVI5-like domain | EVI5-like_dom | 9 |
IPR060075 | 60,075 | Afadin domain | AFDN_dom | Domain | 3,577 | false | false | This domain is found in human Afadin (AFDN), a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton [ ] and is essential for the organisation of adherens junctions [ ]. This domain is predicted to adopt an all-α configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26705"
] | [
"AFDN"
] | [
3577
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-418990",
"R-MMU-418990",
"R-RNO-418990"
] | [
"REACTOME:R-HSA-418990",
"REACTOME:R-MMU-418990",
"REACTOME:R-RNO-418990"
] | 3 | [
"9dva"
] | 1 | [
"PUB00069443",
"PUB00078416",
"PUB00099255",
"PUB00108731"
] | [
"10477764",
"9334353",
"30463011",
"11024295"
] | [
"Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.",
"Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction.",
"A Dock-and-Lock Mechanism Clusters ADAM10 at Cell... | [
1999,
1997,
2018,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3577
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
50,
7,
11,
5,
8
] | 5 | true | Domain | Afadin domain | Afadin domain | AFDN_dom | 3 |
IPR060076 | 60,076 | C2orf42, C-terminal | C2orf42_C | Domain | 1,102 | false | false | This domain is found in the human uncharacterised protein C2orf42 and related metazoan proteins. It is predicted to fold into a curved antiparallel β-sheet with α-helices packed on the concave side. This domain is frequently found in combination with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26708"
] | [
"C2orf42_C"
] | [
1102
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1102
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
2,
1,
1,
4
] | 5 | true | Domain | C2orf42, C-terminal | C2orf42, C-terminal | C2orf42_C | 1 |
IPR060078 | 60,078 | GCN1, HEAT repeat domain | HEAT_GCN1_2 | Domain | 4,866 | false | false | This is a region of HEAT repeats found in human Stalled ribosome sensor GCN1 and similar eukaryotic proteins. GCN1 is a ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, which occurs when a ribosome has stalled during translation, promoting ubiquitination and degrad... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26715"
] | [
"HEAT_GCN1_2"
] | [
4866
] | 1 | [
"REACTOME"
] | [
"R-HSA-9633012"
] | [
"REACTOME:R-HSA-9633012"
] | 1 | [
"8i9x",
"8i9y",
"8i9z",
"8ia0",
"8onz",
"8pv1",
"8pv2",
"8pv3",
"8pv4",
"8pv5",
"8pv6",
"8pv7",
"8pv8",
"8pvk",
"8pvl"
] | 15 | [
"PUB00078021",
"PUB00083123",
"PUB00155654",
"PUB00155655",
"PUB00158485",
"PUB00159901",
"PUB00161999",
"PUB00162000",
"PUB00162001",
"PUB00162002"
] | [
"24333428",
"17915010",
"32610081",
"36638793",
"15937339",
"20360018",
"32324833",
"37651229",
"37951215",
"37951216"
] | [
"Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.",
"Genetic subtraction profiling identifies genes essential for Arabidopsis reproduction and reveals interaction between the female gametophyte and the maternal sporophyte.",
"Ribosome Collis... | [
2014,
2007,
2020,
2023,
2005,
2010,
2020,
2023,
2023,
2023
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Legionella maceachernii",
"marine sediment metagenome"
] | [
4864,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
1,
2,
5,
1,
5,
3,
1,
1,
12
] | 12 | true | Domain | GCN1, HEAT repeat domain | GCN1, HEAT repeat domain | HEAT_GCN1_2 | 2 |
IPR060079 | 60,079 | Target of ERK kinase mpk-1-like, C-terminal domain | TOE2_C | Domain | 3,763 | false | false | This entry represents the C-terminal domain of the target of ERK kinase mpk-1 (TOE-2) from Caenorhabditis elegans and its homologues from mammals DEP domain-containing protein 7 (DEPD7) and similar animal proteins. In TOE-2, this domain is required for localisation to the cell cortex and cleavage during cell division. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27581"
] | [
"TOE2_C"
] | [
3763
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-8980692",
"R-CEL-9013026",
"R-CEL-9013148",
"R-CEL-9013149",
"R-CEL-9013404",
"R-CEL-9013405",
"R-CEL-9013406",
"R-CEL-9013408",
"R-CEL-9013409",
"R-CEL-9013420",
"R-CEL-9013423",
"R-CEL-9013424",
"R-CEL-9035034",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-HSA-90131... | [
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-CEL-9013148",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013404",
"REACTOME:R-CEL-9013405",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013408",
"REACTOME:R-CEL-9013409",
"REACTOME:R-CEL-9013420",
"REACTOME:R-CEL-9013423",
"REACTOM... | 47 | [] | 0 | [
"PUB00162339"
] | [
"24961802"
] | [
"The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Methanobrevibacter arboriphilus JCM 13429 = DSM 1125"
] | [
3762,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
5,
6,
9
] | 5 | true | Domain | Target of ERK kinase mpk-1-like, C-terminal domain | Target of ERK kinase mpk-1-like, C-terminal domain | TOE2_C | 5 |
IPR060080 | 60,080 | E4 SUMO-protein ligase PIAL1, N-terminal domain | PIAL1_N | Domain | 1,019 | false | false | This domain is found at the N-terminal end of E4 SUMO-protein ligase PIAL1 and similar plant proteins. PIAL1 regulates transcriptional gene silencing (TGS) independently of changes in DNA methylation together with MOM1 and PIAL2 [ ]. It contributes to a pathway for proteolytic removal of sumoylation substrates and is i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26716"
] | [
"PIAL1_N"
] | [
1019
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160046",
"PUB00162257"
] | [
"27113777",
"25415977"
] | [
"The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.",
"Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism."
] | [
2016,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1019
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
2,
5
] | 3 | true | Domain | E4 SUMO-protein ligase PIAL1, N-terminal domain | E4 SUMO-protein ligase PIAL1, N-terminal domain | PIAL1_N | 4 |
IPR060083 | 60,083 | F-box only protein 32/25, C-terminal domain | FBXO32/25_C | Domain | 2,193 | false | false | This entry represents the C-terminal domain of F-box only protein 32/25 (FBXO32/25). This domain follows the F-box domain and is involved in protein-protein interactions, particularly with beta-actin through its N-terminal region. This domain may play a role in regulating. These proteins are substrate-recognition compo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27582"
] | [
"FBXO25_C"
] | [
2193
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-BTA-983168",
"R-HSA-8951664",
"R-HSA-9615017",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168",
"R-SSC-8951664",
"R-SSC-983168"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-9615017",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-RNO-983168",
"REACTOME:R-SSC-8951664",
"REACTOME:R-SSC-983168"
] | 11 | [] | 0 | [
"PUB00036145",
"PUB00054583",
"PUB00162486",
"PUB00162487"
] | [
"16278047",
"20473970",
"39986490",
"40307251"
] | [
"Characterization of FBX25, encoding a novel brain-expressed F-box protein.",
"Identification of FBXO25-interacting proteins using an integrated proteomics approach.",
"Methylglyoxal deteriorates macrophage efferocytosis in diabetic wounds through ROS-induced ubiquitination degradation of KLF4.",
"F-box prote... | [
2006,
2010,
2025,
2025
] | 4 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2193
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
4,
8
] | 4 | true | Domain | F-box only protein 32/25, C-terminal domain | F-box only protein 32/25, C-terminal domain | FBXO32/25_C | 7 |
IPR060084 | 60,084 | F-box only protein 32/25, helical bundle domain | FBXO32/25_helical | Domain | 3,183 | false | false | This entry represents a helical bundle domain from F-box only protein 32/25 (FBXO32/25). The helical bundle domain is found in vertebrates and is likely involved in protein-protein interactions [ , ]. This domain is distinct from the C-terminal F-box domain and is involved in substrate recognition. These proteins are s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27576"
] | [
"FBXO32_helical"
] | [
3183
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-BTA-983168",
"R-HSA-8951664",
"R-HSA-9615017",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168",
"R-SSC-8951664",
"R-SSC-983168"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-9615017",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-RNO-983168",
"REACTOME:R-SSC-8951664",
"REACTOME:R-SSC-983168"
] | 11 | [] | 0 | [
"PUB00036145",
"PUB00090908",
"PUB00093149",
"PUB00162486",
"PUB00162487"
] | [
"16278047",
"15531760",
"11679633",
"39986490",
"40307251"
] | [
"Characterization of FBX25, encoding a novel brain-expressed F-box protein.",
"Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase.",
"Identification of ubiquitin ligases required for skeletal muscle atrophy.",
"Methylglyoxal deteriorates macrophage efferocytosis in diabetic wounds through ROS-in... | [
2006,
2005,
2001,
2025,
2025
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3183
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
8,
5,
9
] | 6 | true | Domain | F-box only protein 32/25, helical bundle domain | F-box only protein 32/25, helical bundle domain | FBXO32/25_helical | 5 |
IPR060085 | 60,085 | Integrator complex subunit 8, TPR repeat domain | TPR_INTS8_M | Domain | 1,804 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found centrally in human Integrator complex subunit 8 (INTS8) and similar animal sequences. INTS8 is a component of the integrator complex, a multiprotein complex that terminates RNA polymerase II transcription in the promoter-proximal region of genes [ , , , , ]... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26722"
] | [
"TPR_INTS8_2"
] | [
1804
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6807505",
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-DME-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 3 | [
"7cun",
"7pks",
"7ycx",
"8rbx",
"8rbz",
"8rc4",
"8yjb",
"9eof",
"9ep4",
"9vd9"
] | 10 | [
"PUB00045283",
"PUB00088538",
"PUB00090216",
"PUB00137631",
"PUB00152015",
"PUB00155682",
"PUB00160880",
"PUB00160881",
"PUB00162348"
] | [
"16239144",
"28542170",
"23097424",
"21078872",
"33243860",
"38570683",
"34004147",
"37080207",
"32966759"
] | [
"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.",
"Human mutations in integrator complex subunits link transcriptome integrity to brain development.",
"An RNAi screen identifies additional members of the Drosophila Integrator comp... | [
2005,
2017,
2012,
2011,
2020,
2024,
2021,
2023,
2020
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1804
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
5,
3,
4
] | 5 | true | Domain | Integrator complex subunit 8, TPR repeat domain | Integrator complex subunit 8, TPR repeat domain | TPR_INTS8_M | 4 |
IPR060086 | 60,086 | Integrator complex subunit 8, N-terminal TPR repeats | TPR_INTS8_N | Domain | 2,236 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found at the N-terminal end of human Integrator complex subunit 8 (INTS8) and similar animal sequences. INTS8 is a component of the integrator complex, a multiprotein complex that terminates RNA polymerase II transcription in the promoter-proximal region of genes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26725"
] | [
"TPR_INTS8_3"
] | [
2236
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6807505",
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-DME-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 3 | [
"7cun",
"7pks",
"7ycx",
"8rbx",
"8rbz",
"8rc4",
"8yjb",
"9eof",
"9ep4",
"9vd9"
] | 10 | [
"PUB00045283",
"PUB00088538",
"PUB00090216",
"PUB00137631",
"PUB00152015",
"PUB00155682",
"PUB00160880",
"PUB00160881",
"PUB00162348"
] | [
"16239144",
"28542170",
"23097424",
"21078872",
"33243860",
"38570683",
"34004147",
"37080207",
"32966759"
] | [
"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.",
"Human mutations in integrator complex subunits link transcriptome integrity to brain development.",
"An RNAi screen identifies additional members of the Drosophila Integrator comp... | [
2005,
2017,
2012,
2011,
2020,
2024,
2021,
2023,
2020
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
2227
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
11,
3,
4
] | 6 | true | Domain | Integrator complex subunit 8, N-terminal TPR repeats | Integrator complex subunit 8, N-terminal TPR repeats | TPR_INTS8_N | 1 |
IPR060087 | 60,087 | BEGAIN-like, coiled-coil domain | BEGAIN-like_coil | Domain | 3,350 | false | false | This entry represents a coiled-coil domain from human brain-enriched guanylate kinase-associated protein (BEGAIN). This domain is involved in protein-protein interactions and may contribute to the structural organisation of the postsynaptic density (PSD). The coiled-coil domain is found in vertebrates and is likely inv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27583"
] | [
"BEGAIN_coil"
] | [
3350
] | 1 | [
"REACTOME"
] | [
"R-HSA-6794361"
] | [
"REACTOME:R-HSA-6794361"
] | 1 | [] | 0 | [
"PUB00067641",
"PUB00079152",
"PUB00094054",
"PUB00161825"
] | [
"11602598",
"12097487",
"22841714",
"10819331"
] | [
"Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells.",
"Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein.",
"Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure.",
"Prediction... | [
2001,
2002,
2012,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3350
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
4,
12,
6,
17
] | 5 | true | Domain | BEGAIN-like, coiled-coil domain | BEGAIN-like, coiled-coil domain | BEGAIN-like_coil | 7 |
IPR060088 | 60,088 | PRD1-like, TPR repeat domain | TPR_PRD1 | Domain | 637 | false | false | This is a region of tetratricopeptide (TPR)-like repeats found in Protein PUTATIVE RECOMBINATION INITIATION DEFECT 1 from Arabidopsis thaliana (PRD1) and similar plant sequences. PRD1 is involved in DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26724"
] | [
"TPR_PRD1"
] | [
637
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00087070",
"PUB00097636"
] | [
"19763177",
"17762870"
] | [
"A high throughput genetic screen identifies new early meiotic recombination functions in Arabidopsis thaliana.",
"AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana."
] | [
2009,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
637
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
4,
8
] | 3 | true | Domain | PRD1-like, TPR repeat domain | PRD1-like, TPR repeat domain | TPR_PRD1 | 4 |
IPR060089 | 60,089 | Ras guanine nucleotide exchange factor W, alpha-helical domain | Helical_GefW | Domain | 1,232 | false | false | This entry represents a domain found in Ras guanine nucleotide exchange factor W (GefW) from Dictyostelium discoideum and similar RasGEFs mostly found in lower eukaryotes such as social amoebae, microalgae, and protists. RasGEFs promote the exchange of Ras-bound GDP for GTP [ ]. Social amoebae encode at least 25 RasGEF... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26726"
] | [
"Helical_RasGEFs"
] | [
1232
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-193648",
"R-DDI-354192",
"R-DDI-381676",
"R-DDI-392517",
"R-DDI-9013149"
] | [
"REACTOME:R-DDI-193648",
"REACTOME:R-DDI-354192",
"REACTOME:R-DDI-381676",
"REACTOME:R-DDI-392517",
"REACTOME:R-DDI-9013149"
] | 5 | [] | 0 | [
"PUB00000129",
"PUB00107801",
"PUB00162009",
"PUB00162010"
] | [
"1349465",
"16086850",
"16663904",
"31235476"
] | [
"Guanylyl cyclase-linked receptors.",
"The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles.",
"Role of Silicon in Diatom Metabolism : Cyclic Nucleotide Levels, Nucleotide Cyclase, and Phosphodiesterase Activities during Synchronized Growth of Cylindrotheca fusiformis.",
"An unusua... | [
1992,
2005,
1984,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
1230
] | 2 | [] | [] | 0 | true | Domain | Ras guanine nucleotide exchange factor W, alpha-helical domain | Ras guanine nucleotide exchange factor W, alpha-helical domain | Helical_GefW | 9 |
IPR060090 | 60,090 | Histone transcription regulator 3, helical domain | HIR3_helical | Domain | 1,415 | false | false | This entry represents a helical domain from histone transcription regulator 3 (HIR3) fungal proteins. This domain is predominantly α-helical in structure. The specific function of this helical domain remains to be determined, but it likely contributes to the protein's role in chromatin remodelling and nucleosome assemb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27584"
] | [
"HIR3_helical"
] | [
1415
] | 1 | [
"REACTOME"
] | [
"R-SCE-2559584"
] | [
"REACTOME:R-SCE-2559584"
] | 1 | [
"8gha",
"8ghl",
"8ghm",
"8ghn",
"8gix"
] | 5 | [
"PUB00033373",
"PUB00161943",
"PUB00162021"
] | [
"12524332",
"15123810",
"9001207"
] | [
"Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.",
"The diploid genome sequence of Candida albicans.",
"Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the... | [
2002,
2004,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1415
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Histone transcription regulator 3, helical domain | Histone transcription regulator 3, helical domain | HIR3_helical | 4 |
IPR060091 | 60,091 | HIR3-like, helical bundle domain | HIR3-like_bundle | Domain | 2,031 | false | false | This entry represents a helical bundle domain found in histone transcription regulator 3 (HIR3) fungal proteins and in plant Calcineurin-binding protein 1 (CABIN1). This domain consists of multiple α-helices arranged in a bundle structure and is involved in protein-protein interactions within chromatin regulatory compl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27595"
] | [
"HIR3_bundle"
] | [
2031
] | 1 | [
"REACTOME"
] | [
"R-SCE-2559584"
] | [
"REACTOME:R-SCE-2559584"
] | 1 | [
"8gha",
"8ghl",
"8ghm",
"8ghn",
"8gix"
] | 5 | [
"PUB00033373",
"PUB00161943",
"PUB00162021"
] | [
"12524332",
"15123810",
"9001207"
] | [
"Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.",
"The diploid genome sequence of Candida albicans.",
"Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the... | [
2002,
2004,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2031
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
8,
1,
2,
1,
1,
3
] | 6 | true | Domain | HIR3-like, helical bundle domain | HIR3-like, helical bundle domain | HIR3-like_bundle | 8 |
IPR060092 | 60,092 | Histone transcription regulator 3 , N-terminal TPR repeats | HIR3_N_TPR | Domain | 1,393 | false | false | This entry represents the N-terminal tetratricopeptide repeat (TPR) domain found in histone transcription regulator 3 (HIR3) fungal proteins, including HIR3 from Candida albicans. The specific function of this N-terminal TPR domain remains to be determined. HIR3 belongs to the HIR3/CABIN1 family and has a role in nucle... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27596"
] | [
"HIR3_TPR_N"
] | [
1393
] | 1 | [
"REACTOME"
] | [
"R-SCE-2559584"
] | [
"REACTOME:R-SCE-2559584"
] | 1 | [
"8gha",
"8ghl",
"8ghm",
"8ghn",
"8gix"
] | 5 | [
"PUB00033373",
"PUB00162021"
] | [
"12524332",
"9001207"
] | [
"Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.",
"Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle."
] | [
2002,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1393
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Histone transcription regulator 3 , N-terminal TPR repeats | Histone transcription regulator 3 , N-terminal TPR repeats | HIR3_N_TPR | 8 |
IPR060094 | 60,094 | HIR3, C-terminal helical domain | HIR3_C | Domain | 57 | false | false | This entry represents the C-terminal helical domain of histone transcription regulator 3 (HIR3) and related proteins from saccharomycetes. This C-terminal domain consists of multiple α-helices arranged in a compact fold. The C-terminal region contains a disordered segment that may provide flexibility for protein intera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27648"
] | [
"HIR3_C"
] | [
57
] | 1 | [
"REACTOME"
] | [
"R-SCE-2559584"
] | [
"REACTOME:R-SCE-2559584"
] | 1 | [
"8gha",
"8ghl",
"8ghm",
"8ghn"
] | 4 | [
"PUB00033373",
"PUB00062947",
"PUB00113139",
"PUB00162021"
] | [
"12524332",
"16303565",
"19683497",
"9001207"
] | [
"Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.",
"Replication-independent histone deposition by the HIR complex and Asf1.",
"Two-color cell array screen reveals interdependent roles for histone chaperones... | [
2002,
2005,
2009,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
57
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | HIR3, C-terminal helical domain | HIR3, C-terminal helical domain | HIR3_C | 9 |
IPR060095 | 60,095 | PF3D7_0210200-like, helix hairpin domain | PF3D7_0210200-like_HH | Domain | 70 | false | false | This entry represents a helix hairpin domain found in Plasmodium falciparum protein PF3D7_0210200 and related proteins. The domain adopts a helix hairpin structure. The full-length protein is 2588 amino acids and contains predicted coiled-coil regions and multiple disordered regions. The protein is localised to the mer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27587"
] | [
"PF3D7_0210200_HH"
] | [
70
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162224"
] | [
"17653272"
] | [
"Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
70
] | 1 | [] | [] | 0 | true | Domain | PF3D7_0210200-like, helix hairpin domain | PF3D7_0210200-like, helix hairpin domain | PF3D7_0210200-like_HH | 6 |
IPR060096 | 60,096 | PF3D7_0210200, 7th domain | PF3D7_0210200_7th | Domain | 73 | false | false | This entry represents the 7th domain found in PF3D7_0210200 proteins from Plasmodium falciparum. This domain is characterised by a helical structure with a short β-sheet adjacent to the C-terminal region. The full-length protein is a large uncharacterised polypeptide that contains coiled coil regions and has been ident... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27571"
] | [
"PF3D7_0210200_7th"
] | [
73
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162224"
] | [
"17653272"
] | [
"Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
73
] | 1 | [] | [] | 0 | true | Domain | PF3D7_0210200, 7th domain | PF3D7_0210200, 7th domain | PF3D7_0210200_7th | 4 |
IPR060097 | 60,097 | PF3D7_0210200, sixth domain | PF3D7_0210200_6th | Domain | 69 | false | false | This entry represents the sixth domain of Plasmodium falciparum protein PF3D7_0210200 and related proteins. The domain adopts a helix hairpin structure. The protein contains predicted coiled-coil regions and multiple disordered regions. The protein is localised to the merozoite, and a peptide fragment has been identifi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27588"
] | [
"PF3D7_0210200_6th"
] | [
69
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162224"
] | [
"17653272"
] | [
"Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
69
] | 1 | [] | [] | 0 | true | Domain | PF3D7_0210200, sixth domain | PF3D7_0210200, sixth domain | PF3D7_0210200_6th | 8 |
IPR060098 | 60,098 | Transformer protein 2, helical domain | TRA2_helical | Domain | 18 | false | false | This entry represents a helical domain found in the sex-determining transformer protein 2 (TRA-2) from Caenorhabditis species. The function of this helical domain remains to be determined. TRA-2 is a multi-pass transmembrane protein that plays a major role in controlling sexual cell fates [ ]. The full-length protein c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27590"
] | [
"TRA2_helical"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076871"
] | [
"1498366"
] | [
"tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
18
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Transformer protein 2, helical domain | Transformer protein 2, helical domain | TRA2_helical | 6 |
IPR060099 | 60,099 | Transformer protein 2, C-terminal domain | TRA2_C | Domain | 54 | false | false | This entry represents the C-terminal intracellular domain of the transformer protein 2 (TRA-2) from Caenorhabditis elegans and proteins from related species. This domain contains the MX regulatory region, which is required for binding to the TRA-1 transcription factor and mediates post-translational regulation essentia... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27573"
] | [
"TRA2_C"
] | [
54
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076871",
"PUB00076872",
"PUB00162353",
"PUB00162354"
] | [
"1498366",
"10364161",
"11124807",
"11250902"
] | [
"tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.",
"Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3.",
"Direct protein-protein interaction between the intracel... | [
1992,
1999,
2000,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
54
] | 1 | [
"Caenorhabditis elegans"
] | [
5
] | 1 | true | Domain | Transformer protein 2, C-terminal domain | Transformer protein 2, C-terminal domain | TRA2_C | 4 |
IPR060100 | 60,100 | Transformer protein 2, fourth domain | TRA2_4th | Domain | 18 | false | false | This entry represents the fourth domain of the sex-determining transformer protein 2 (TRA-2) from Caenorhabditis species. The function of this fourth domain remains to be determined. TRA-2 is a multi-pass transmembrane protein that plays a major role in controlling sexual cell fates [ ]. The full-length protein contain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27591"
] | [
"TRA2_4th"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076871"
] | [
"1498366"
] | [
"tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
18
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Transformer protein 2, fourth domain | Transformer protein 2, fourth domain | TRA2_4th | 2 |
IPR060101 | 60,101 | SAM-like helix-hairpin-helix tandem | HHH_SAM-like | Domain | 97,264 | false | false | This entry represents a SAM-like helix-hairpin-helix domain found in functionally diverse proteins involved in DNA repair, recombination, transcription termination etc. This domain has a fold that is structurally similar to SAM domains. It is composed of two helix-hairpin-helix motifs which are known DNA interaction mo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14520"
] | [
"HHH_5"
] | [
97264
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5685938",
"R-BTA-5685942",
"R-BTA-5693568",
"R-BTA-5693579",
"R-BTA-5693616",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-6782135",
"R-BTA-6783310",
"R-BTA-912446",
"R-CFA-5685938",
"R-CFA-5685942",
"R-CFA-5693568",
"R-CFA-5693579",
"R-CFA-5693616",
"R-CFA-912446",
"R-DME-5693616... | [
"REACTOME:R-BTA-5685938",
"REACTOME:R-BTA-5685942",
"REACTOME:R-BTA-5693568",
"REACTOME:R-BTA-5693579",
"REACTOME:R-BTA-5693616",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6783310",
"REACTOME:R-BTA-912446",
"REACTOME:R-CFA-5685938",
"REACTOME... | 57 | [
"1b22",
"1bdx",
"1c7y",
"1cuk",
"1d8l",
"1dgs",
"1hjp",
"1ixr",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kft",
"1kqs",
"1m1k",
"1m90",
"1n8r",
"1nji",
"1pzn",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1szp",
"1t4g",
"1v5w",
"1v9p"... | 252 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
6021,
80448,
8832,
46,
1917
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
3,
6,
5,
4,
12,
8,
1,
9,
12,
2,
2,
14
] | 13 | true | Domain | SAM-like helix-hairpin-helix tandem | SAM-like helix-hairpin-helix tandem | HHH_SAM-like | 3 |
IPR060102 | 60,102 | Bombesin receptor-activated protein C6orf89, N-terminal | C6orf89_N | Domain | 1,009 | false | false | This entry represents the N-terminal helix hairpin domain of bombesin receptor-activated protein (BRAP), also known as C6orf89. This small structural domain is found in metazoans, particularly vertebrates. The domain is located in the cytoplasmic N-terminal region of BRAP proteins. The specific function of this domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28222"
] | [
"C6orf89_N"
] | [
1009
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088689",
"PUB00088690",
"PUB00161839"
] | [
"21857995",
"26460487",
"23460338"
] | [
"Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells.",
"Bombesin Receptor-Activated Protein (BRAP) Modulates NF-κB Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity.",
"C6orf89 encodes three distinct HDAC enhancers that function in t... | [
2011,
2016,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1009
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
14,
11
] | 4 | true | Domain | Bombesin receptor-activated protein C6orf89, N-terminal | Bombesin receptor-activated protein C6orf89, N-terminal | C6orf89_N | 1 |
IPR060103 | 60,103 | MTBMA_p00010-like, P-loop domain | P-loop_MTBMA_p00010-like | Domain | 911 | false | false | This entry represents the second domain of MTBMA_p00010, an uncharacterised protein from Methanothermobacter marburgensis. MTBMA_p00010 is a 804 amino acid protein (gene MTBMA_p00010) located on plasmid pMTBMA4. This domain adopts a P-loop fold, which is typically associated with nucleotide binding and hydrolysis activ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27228"
] | [
"MTBMA_p00010_2nd"
] | [
911
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rotaria socialis",
"Sulfolobus virus Kamchatka 1",
"metagenomes"
] | [
137,
746,
3,
1,
24
] | 5 | [] | [] | 0 | true | Domain | MTBMA_p00010-like, P-loop domain | MTBMA_p00010-like, P-loop domain | P-loop_MTBMA_p00010-like | 8 |
IPR060105 | 60,105 | SSO2105-like, N-terminal domain | SSO2105-like_N | Domain | 707 | false | false | This entry represents the N-terminal domain of SSO2105, an uncharacterised protein from Saccharolobus solfataricus. This region shows structural similarity to the miniature CRISPR-Cas12f1 proteins, which are compact RNA-guided DNA endonucleases that function as asymmetric homodimers for DNA cleavage. However, SSO2105 i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27229"
] | [
"SSO2105_N"
] | [
707
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"ecological metagenomes"
] | [
97,
601,
4,
5
] | 4 | [] | [] | 0 | true | Domain | SSO2105-like, N-terminal domain | SSO2105-like, N-terminal domain | SSO2105-like_N | 9 |
IPR060106 | 60,106 | Large ribosomal subunit protein uL10m, C-terminal, fungi | MRPL11_C_fungi | Domain | 1,207 | false | false | This entry represents the C-terminal helical region of mitochondrial ribosomal protein L11 (MRPL11/uL10m). This entry is found in fungi and contains disordered regions at the C-terminal. MRPL11 is a component of the mitochondrial large ribosomal subunit (54S) and is part of the mitoribosome machinery responsible for sy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28227"
] | [
"MRPL11_C"
] | [
1207
] | 1 | [] | [] | [] | 0 | [
"6ywe",
"6yws",
"6ywv",
"6ywx",
"6ywy"
] | 5 | [
"PUB00162166"
] | [
"33056988"
] | [
"Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
1196,
11
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Large ribosomal subunit protein uL10m, C-terminal, fungi | Large ribosomal subunit protein uL10m, C-terminal, fungi | MRPL11_C_fungi | 4 |
IPR060107 | 60,107 | Small cell adhesion glycoprotein, transmembrane helix | SMAGP_TM | Domain | 984 | false | false | This entry represents the transmembrane helix in small cell adhesion glycoprotein (SMAGP) and related sequences from vertebrates. SMAGP is a small transmembrane glycoprotein that contains a single-pass type III transmembrane helix and is heavily O-glycosylated with sialic acid modifications. SMAGP is localised predomin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28228"
] | [
"SMAGP"
] | [
984
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056654",
"PUB00056655"
] | [
"15021913",
"15986429"
] | [
"SMAGP, a new small trans-membrane glycoprotein altered in cancer.",
"Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line."
] | [
2004,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
984
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
4,
4
] | 3 | true | Domain | Small cell adhesion glycoprotein, transmembrane helix | Small cell adhesion glycoprotein, transmembrane helix | SMAGP_TM | 2 |
IPR060108 | 60,108 | Uncharacterized protein AF_1625, C-terminal domain | AF_1625_C | Domain | 335 | false | false | This entry represents the C-terminal domain of the uncharacterised protein AF_1625 from Archaeoglobus fulgidus and similar sequences from related archaeal species. The full-length protein is 581 amino acids with a molecular weight of approximately 64.9 kDa and contains an N-terminal signal peptide (residues 1-28) that ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27237"
] | [
"AF_1625_C"
] | [
335
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacillus phage G",
"Bacteria",
"Durusdinium trenchii",
"ecological metagenomes"
] | [
53,
1,
274,
1,
6
] | 5 | [] | [] | 0 | true | Domain | Uncharacterized protein AF_1625, C-terminal domain | Uncharacterized protein AF_1625, C-terminal domain | AF_1625_C | 2 |
IPR060109 | 60,109 | CLIP1/2, coiled-coil domain | CC_CLIP1/2 | Domain | 4,259 | false | false | This entry represents a coiled-coil domain found in the middle region in CLIP1 (CAP-Gly domain-containing linker protein 1) and at the C-terminal of CLIP2 from animals. CLIP1 binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton [ , , ]. CLIP2 may link microtubules to dendriti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27241"
] | [
"CLIP1"
] | [
4259
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-141444",
"R-GGA-2467813",
"R-GGA-2500257",
"R-GGA-5663220",
"R-GGA-9648025",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5626467",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-HSA-9842640",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5626467",
... | [
"REACTOME:R-GGA-141444",
"REACTOME:R-GGA-2467813",
"REACTOME:R-GGA-2500257",
"REACTOME:R-GGA-5663220",
"REACTOME:R-GGA-9648025",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5626467",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-... | 27 | [] | 0 | [
"PUB00047327",
"PUB00049031",
"PUB00068284",
"PUB00068285"
] | [
"17563362",
"17889670",
"9427243",
"12433698"
] | [
"Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.",
"Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.",
"CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies.",
"Hod... | [
2007,
2007,
1997,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
3,
4256
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
12,
9,
16
] | 4 | true | Domain | CLIP1/2, coiled-coil domain | CLIP1/2, coiled-coil domain | CC_CLIP1/2 | 9 |
IPR060110 | 60,110 | FAM120A/B/C, helical domain | FAM120A-like_helical | Domain | 3,868 | false | false | This entry represents a domain in Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A), FAM120B, FAM120C and similar proteins found in animals, including the Drosophila homologue protein asteroid. This domain is predicted to show an all α-configuration. FAM120A is a component of the oxidative stress-induced ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27242"
] | [
"FAM120A"
] | [
3868
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1989781",
"R-HSA-381340"
] | [
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-381340"
] | 2 | [] | 0 | [
"PUB00061802"
] | [
"19015244"
] | [
"A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3868
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
11,
5,
13
] | 5 | true | Domain | FAM120A/B/C, helical domain | FAM120A/B/C, helical domain | FAM120A-like_helical | 6 |
IPR060111 | 60,111 | FMNK-like, N-terminal | FMNK-like_N | Domain | 770 | false | false | This entry represents a domain found at the N-terminal end of uncharacterised proteins from fungi. Most of these proteins contain Riboflavin kinase domain and are likely putative Flavin mononucleotide kinases (FMNK). Riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26728"
] | [
"FMNK-like_N"
] | [
770
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00030175",
"PUB00161966"
] | [
"14580199",
"19714214"
] | [
"Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.",
"The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion."
] | [
2003,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
770
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | FMNK-like, N-terminal | FMNK-like, N-terminal | FMNK-like_N | 1 |
IPR060112 | 60,112 | GtfB, second domain | GtfB_2nd | Domain | 1,052 | false | false | This entry represents the second domain in GtfB proteins found in Streptococcus pneumoniae. This domain contains a glycosyltransferase 1 fold. GtfB is a 445 amino acid protein required for polymorphic O-glycosylation of serine-rich repeat proteins. GtfB, together with GtfA, forms a two-protein enzyme complex that is in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27244"
] | [
"GtfB_M"
] | [
1052
] | 1 | [] | [] | [] | 0 | [
"5e9t",
"5e9u"
] | 2 | [
"PUB00064842",
"PUB00064843",
"PUB00064844",
"PUB00153994",
"PUB00161993"
] | [
"20971868",
"18083807",
"21862581",
"24936067",
"28246170"
] | [
"Purification and characterization of an active N-acetylglucosaminyltransferase enzyme complex from Streptococci.",
"Interaction between two putative glycosyltransferases is required for glycosylation of a serine-rich streptococcal adhesin.",
"A molecular chaperone mediates a two-protein enzyme complex and glyc... | [
2010,
2008,
2011,
2014,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
1049,
3
] | 2 | [] | [] | 0 | true | Domain | GtfB, second domain | GtfB, second domain | GtfB_2nd | 2 |
IPR060113 | 60,113 | TMA17, alpha-helical domain | TMA17_helical | Domain | 1,678 | false | false | This entry represents a domain found in Translation machinery-associated protein 17 (TMA17) and related proteins. These proteins function as ATPase-dedicated chaperones, essential for the formation of the RPT6-RPT3 ATPase pair, an early and critical step in proteasome assembly. They play a key role in maintaining homeo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26729"
] | [
"TMA17_helical"
] | [
1678
] | 1 | [] | [] | [] | 0 | [
"6ql5",
"6ql7"
] | 2 | [
"PUB00088612",
"PUB00162333"
] | [
"25042801",
"32160528"
] | [
"An inducible chaperone adapts proteasome assembly to stress.",
"Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase."
] | [
2014,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Novilysobacter selenitireducens"
] | [
1677,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | TMA17, alpha-helical domain | TMA17, alpha-helical domain | TMA17_helical | 6 |
IPR060114 | 60,114 | CRISPR-associated protein MJ1674, second domain | MJ1674_2nd | Domain | 281 | false | false | This entry represents the second domain of the CRISPR-associated protein MJ1674. The specific function of this second domain remains to be determined. This domain is also present in related CRISPR-associated bacterial proteins. This domain contains an all α-helical fold. The full-length protein is 634 amino acids with ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27248"
] | [
"MJ1674_2nd"
] | [
281
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005221"
] | [
"8688087"
] | [
"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"hydrothermal vent metagenome"
] | [
13,
267,
1
] | 3 | [] | [] | 0 | true | Domain | CRISPR-associated protein MJ1674, second domain | CRISPR-associated protein MJ1674, second domain | MJ1674_2nd | 6 |
IPR060115 | 60,115 | LECT2, C-terminal | LECT2_C | Domain | 144 | false | false | This entry represents the C-terminal domain of LECT2 from Caenorhabditis elegans and related proteins from nematodes. LECT2/MIM-1 proteins are involved in the development and morphogenesis of somatosensory dendritic arbors, particularly those extending from PVD and FLP sensory neurons. They function as muscle-derived d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26730"
] | [
"LECT2_C"
] | [
144
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162123",
"PUB00162124"
] | [
"27451901",
"27705746"
] | [
"Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites.",
"A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in <i>C. elegans</i>."
] | [
2016,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
144
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | LECT2, C-terminal | LECT2, C-terminal | LECT2_C | 1 |
IPR060116 | 60,116 | Uncharacterized protein MJ0330, N-terminal P-loop domain | MJ0330_N | Domain | 255 | false | false | This entry represents the N-terminal P-loop domain of the uncharacterised protein MJ0330 from Methanocaldococcus jannaschii and related archaeal species. This domain belongs to the P-loop containing nucleotide triphosphate hydrolase superfamily suggesting it may have nucleotide binding and/or hydrolysis activity. The s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27249"
] | [
"MJ0330_N"
] | [
255
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanococcales",
"Viruses",
"metagenomes"
] | [
61,
7,
151,
36
] | 4 | [] | [] | 0 | true | Domain | Uncharacterized protein MJ0330, N-terminal P-loop domain | Uncharacterized protein MJ0330, N-terminal P-loop domain | MJ0330_N | 2 |
IPR060117 | 60,117 | Adenylate-forming reductase 03009-like, C-terminal | 03009-like_C | Domain | 4,511 | false | false | This entry represents the C-terminal domain of adenylate-forming reductases 03009 and 06235 from Coprinopsis cinerea and related proteins mainly from fungi. Adenylate forming reductases are natural product biosynthesis enzymes that resemble non-ribosomal peptide synthetases but act on a single substrate rather than con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26733"
] | [
"03009_C"
] | [
4511
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161775",
"PUB00161776"
] | [
"27457378",
"25085485"
] | [
"Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases.",
"Functional and phylogenetic divergence of fungal adenylate-forming reductases."
] | [
2018,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
374,
4136,
1
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
1,
2
] | 4 | true | Domain | Adenylate-forming reductase 03009-like, C-terminal | Adenylate-forming reductase 03009-like, C-terminal | 03009-like_C | 5 |
IPR060118 | 60,118 | HP_1247/jhp_1168, middle domain | HP_1247_M | Domain | 422 | false | false | This entry represents the middle domain of HP_1247 and Protein jhp_1168 from Helicobacter pylori. HP_1247 is a 340 amino acid protein that may function as the equivalent of DNA polymerase III delta subunit (HolA). While the full-length protein contains a P-loop nucleotide triphosphate hydrolase domain and shows interac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27254"
] | [
"HP_1247_M"
] | [
422
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Zygotorulaspora mrakii",
"metagenomes"
] | [
402,
1,
19
] | 3 | [] | [] | 0 | true | Domain | HP_1247/jhp_1168, middle domain | HP_1247/jhp_1168, middle domain | HP_1247_M | 3 |
IPR060119 | 60,119 | YidX, conserved domain | YidX | Domain | 783 | false | false | This entry represents the structural domain of the YidX protein found in Escherichia coli and Shigella flexneri. The specific function of this domain remains to be determined. It adopts a β-barrel fold. YidX is predicted to be a single-pass membrane protein with a transmembrane helix at the N-terminal. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27265"
] | [
"YidX_N"
] | [
783
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Trichuris trichiura"
] | [
782,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YidX, conserved domain | YidX, conserved domain | YidX | 2 |
IPR060120 | 60,120 | L-aspartate--L-methionine ligase, N-terminal domain | LdmS_N | Domain | 325 | false | false | This entry represents the N-terminal domain of the L-aspartate--L- methionine ligase (LdmS) found in Staphylococcus aureus. While the full-length protein has characterised ligase activity, the specific function of this N-terminal domain remains to be determined. This entry includes L-amino acid ligases that catalyse th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27267"
] | [
"LdmS_N"
] | [
325
] | 1 | [] | [] | [] | 0 | [
"7r8p",
"7r8q"
] | 2 | [
"PUB00162122"
] | [
"35988643"
] | [
"Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
324,
1
] | 2 | [] | [] | 0 | true | Domain | L-aspartate--L-methionine ligase, N-terminal domain | L-aspartate--L-methionine ligase, N-terminal domain | LdmS_N | 6 |
IPR060121 | 60,121 | Cyclic 2,3-diphosphoglycerate synthetase, N-terminal domain | CpgS_N | Domain | 133 | false | false | This entry represents the N-terminal domain of cyclic 2,3- diphosphoglycerate synthetase (CpgS), found in Archaea and some thermophilic bacteria. This N-terminal domain is distinct from both the central P-loop nucleotide-binding domain and the C-terminal domain. The specific role of this N-terminal domain in catalysis ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27272"
] | [
"CpgS_N"
] | [
133
] | 1 | [
"EC",
"METACYC"
] | [
"6.5.1.9",
"PWY-8098"
] | [
"EC:6.5.1.9",
"METACYC:PWY-8098"
] | 2 | [
"8ork",
"8oru"
] | 2 | [
"PUB00046149",
"PUB00053142"
] | [
"9811660",
"2226838"
] | [
"Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.",
"Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-... | [
1998,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
27,
100,
6
] | 3 | [] | [] | 0 | true | Domain | Cyclic 2,3-diphosphoglycerate synthetase, N-terminal domain | Cyclic 2,3-diphosphoglycerate synthetase, N-terminal domain | CpgS_N | 5 |
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