interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060122 | 60,122 | Histone-lysine N-methyltransferase SUVR5, N-terminal | SUVR5_N | Domain | 721 | false | false | This entry describes the N-terminal domain of Histone-lysine N-methyltransferase SUVR5 from Arabidopsis thaliana and related proteins mainly from plants. This domain is predicted to adopt an SH3-like fold and appears to be exclusive to SUVR5, as other methyltransferases in Arabidopsis contain a different N-terminal dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26734"
] | [
"SUVR5_N"
] | [
721
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091222",
"PUB00162307"
] | [
"17224141",
"23071452"
] | [
"C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier.",
"The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner."
] | [
2007,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
721
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
4,
18
] | 3 | true | Domain | Histone-lysine N-methyltransferase SUVR5, N-terminal | Histone-lysine N-methyltransferase SUVR5, N-terminal | SUVR5_N | 8 |
IPR060124 | 60,124 | Coenzyme F430 synthetase CfbE | CfbE | Family | 236 | false | false | CfbE is 472 amino acids and catalyses the final step in coenzyme F430 biosynthesis, forming the carbocyclic F ring by intramolecular C-C bond formation from 15,17(3)-seco-F430-17(3)-acid using ATP ( ). Coenzyme F430 is the unique nickel-containing tetrapyrrole prosthetic group of methyl-coenzyme M reductase, which play... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033197"
] | [
"F430_CfbE"
] | [
236
] | 1 | [
"EC",
"METACYC"
] | [
"6.4.1.9",
"PWY-5196"
] | [
"EC:6.4.1.9",
"METACYC:PWY-5196"
] | 2 | [] | 0 | [
"PUB00087319",
"PUB00104111"
] | [
"28225763",
"27846569"
] | [
"Elucidation of the biosynthesis of the methane catalyst coenzyme F430.",
"The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea."
] | [
2017,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
232,
4
] | 2 | [] | [] | 0 | true | Family | Coenzyme F430 synthetase CfbE | Coenzyme F430 synthetase CfbE | CfbE | 2 |
IPR060125 | 60,125 | Coiled-coil domain-containing protein 33, N-terminal | Ccdc33_N | Domain | 298 | false | false | This entry represents the N-terminal domain of human Coiled-coil domain-containing protein 33 (Ccdc33) and related proteins from animals. The function of these proteins have not been elucidated yet. This domain is predicted to adopt a structure with some similarity to known C2 domains. This domain is not present in the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26735"
] | [
"Ccdc33_N"
] | [
298
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
298
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2
] | 3 | true | Domain | Coiled-coil domain-containing protein 33, N-terminal | Coiled-coil domain-containing protein 33, N-terminal | Ccdc33_N | 9 |
IPR060126 | 60,126 | N-acetylglucosamine-1-phosphotransferase subunit alpha/beta, Ig-like domain | Ig_GNPTAB | Domain | 1,388 | false | false | This immunoglobulin-like (Ig-like) domain is found in human N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar sequences. GNPTAB catalyses the formation of mannose 6-phosphate (MP6) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues play a role in the vesic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26737"
] | [
"Ig_GNPTAB"
] | [
1388
] | 1 | [
"EC"
] | [
"2.7.8.17"
] | [
"EC:2.7.8.17"
] | 1 | [
"7s05",
"7s06",
"9bgf"
] | 3 | [
"PUB00075655",
"PUB00090104",
"PUB00097530",
"PUB00102011"
] | [
"16299590",
"19955174",
"23733939",
"28918368"
] | [
"Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.",
"Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.",
"The DMAP interaction domain of UDP-GlcNAc:lysosoma... | [
2005,
2010,
2013,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1388
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
4
] | 4 | true | Domain | N-acetylglucosamine-1-phosphotransferase subunit alpha/beta, Ig-like domain | N-acetylglucosamine-1-phosphotransferase subunit alpha/beta, Ig-like domain | Ig_GNPTAB | 1 |
IPR060127 | 60,127 | AtC3H22-like, SH3 domain | SH3_AtC3H22 | Domain | 505 | false | false | This SH3 (Src homology-3) domain is found in Zinc finger CCCH domain-containing protein 22 from Arabidopsis thaliana (AtC3H22) and similar plant sequences, including Zinc finger CCCH domain-containing protein 18 (OsC3H18). This domain is often found associated with and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26738"
] | [
"SH3_AtC3H22"
] | [
505
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
505
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
2,
4
] | 3 | true | Domain | AtC3H22-like, SH3 domain | AtC3H22-like, SH3 domain | SH3_AtC3H22 | 5 |
IPR060128 | 60,128 | MJ0349-like, C-terminal domain | MJ0349-like_C | Domain | 70 | false | false | This entry represents the C-terminal domain in MJ0349 and related archaeal proteins, including MJ1072, MJ1074 and MJECL16. This domain is found in the hyperthermophilic archaeon Methanocaldococcus jannaschii. The proteins range from 70-116 amino acids in length. Several members contain predicted transmembrane helices a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27276"
] | [
"MJ0349"
] | [
70
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanocaldococcaceae",
"Methanocaldococcus fervens tailed virus 1",
"hot springs metagenome"
] | [
56,
10,
1,
3
] | 4 | [] | [] | 0 | true | Domain | MJ0349-like, C-terminal domain | MJ0349-like, C-terminal domain | MJ0349-like_C | 4 |
IPR060129 | 60,129 | Vacoular membrane protein SCY_4732-like, transmembrane segment | SCY_4732_TM | Domain | 1,312 | false | false | This entry represents the transmembrane segment of SCY_4732 protein which belongs to the PRM5 family of vacuolar membrane proteins found in ascomycetes. They are regulated by the cell integrity signalling pathway and by pheromone [ , ]. Members are single-pass membrane proteins localised to the vacuolar membrane and co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28230"
] | [
"SCY_4732_"
] | [
1312
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061781",
"PUB00162289"
] | [
"11062271",
"10594829"
] | [
"Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating.",
"Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway."
] | [
2000,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Candidatus Dojkabacteria bacterium",
"Eukaryota"
] | [
1,
1311
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
3
] | 2 | true | Domain | Vacoular membrane protein SCY_4732-like, transmembrane segment | Vacoular membrane protein SCY_4732-like, transmembrane segment | SCY_4732_TM | 4 |
IPR060130 | 60,130 | CASZ1-like, zinc finger | Zf-C2H2_CASZ1 | Domain | 2,437 | false | false | This predicted C2H2-type zinc finger is found repeated nine times in human Zinc finger protein castor homolog 1 (CASZ1) and related metazoan sequences. CASZ1 is a transcriptional activator involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26743"
] | [
"zf-C2H2_CASZ1"
] | [
2437
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090868",
"PUB00162434"
] | [
"23639441",
"27693370"
] | [
"CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway.",
"CASZ1 loss-of-function mutation associated with congenital heart disease."
] | [
2013,
2016
] | 2 | [
"IPR013087"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Nitrosotalea devaniterrae"
] | [
2436,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
45,
3,
4,
7,
5
] | 6 | true | Domain | CASZ1-like, zinc finger | CASZ1-like, zinc finger | Zf-C2H2_CASZ1 | 1 |
IPR060131 | 60,131 | STB2/6, C-terminal helix | STB2/6_C | Domain | 1,212 | false | false | This entry represents the C-terminal helical segment of STB2 protein and its paralogue from fungi, particularly Saccharomyces cerevisiae. STB2 is a Sin3 binding proteins that interact with the Sin3 transcriptional co-repressor complex [ ]. STB2 contains multiple serine phosphorylation sites. The specific function of th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28231"
] | [
"STB2_C"
] | [
1212
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044498"
] | [
"9393435"
] | [
"Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Eukaryota"
] | [
2,
1210
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Domain | STB2/6, C-terminal helix | STB2/6, C-terminal helix | STB2/6_C | 2 |
IPR060132 | 60,132 | Like early starvation, beta-sheet domain | LESV_beta-sheet | Domain | 1,469 | false | false | This entry represents a β-sheet domain found within LESV (Like Early Starvation) chloroplastic proteins in plants. LESV proteins are alpha-glucan binding proteins that bind preferentially to highly ordered alpha-glucans such as starch and crystalline maltodextrins [ , ]. The full-length proteins are involved in the org... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28232"
] | [
"LESV"
] | [
1469
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162125",
"PUB00162126"
] | [
"27207856",
"34367195"
] | [
"The Starch Granule-Associated Protein EARLY STARVATION1 Is Required for the Control of Starch Degradation in Arabidopsis thaliana Leaves.",
"EARLY STARVATION 1 Is a Functionally Conserved Protein Promoting Gravitropic Responses in Plants by Forming Starch Granules."
] | [
2016,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1469
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
7,
18
] | 3 | true | Domain | Like early starvation, beta-sheet domain | Like early starvation, beta-sheet domain | LESV_beta-sheet | 5 |
IPR060133 | 60,133 | Dicer-like protein 1, PAZ domain | PAZ_Dcl1 | Domain | 1,063 | false | false | This predicted PAZ domain is found in Dicer-like protein 1 from Aspergillus fumigatus (Dcl1) and similar fungal sequences. Dcl1 is a Dicer-like endonuclease involved in cleaving double -stranded RNA in the RNA interference (RNAi) pathway. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26744"
] | [
"PAZ_Dcl1"
] | [
1063
] | 1 | [
"EC",
"EC",
"METACYC"
] | [
"3.1.26.-",
"3.6.4.-",
"PWY-7250"
] | [
"EC:3.1.26.-",
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR003100"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1063
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Dicer-like protein 1, PAZ domain | Dicer-like protein 1, PAZ domain | PAZ_Dcl1 | 2 |
IPR060134 | 60,134 | YIPF3, N-terminal domain | YIPF3_N | Domain | 1,028 | false | false | This entry represents the N-terminal cytoplasmic domain of YIPF3 (YIP1 protein 3) and similar sequences mainly found in vertebrates. YIPF3 is a multi-pass transmembrane protein involved in the maintenance of Golgi structure and may play a role in hematopoiesis [ , ]. The full-length protein localises to the cis-Golgi n... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28233"
] | [
"YIPF3_N"
] | [
1028
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060866",
"PUB00060867"
] | [
"12490290",
"21757827"
] | [
"Characterization of a novel hematopoietic marker expressed from early embryonic hematopoietic stem cells to adult mature lineages.",
"Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip domain family proteins."
] | [
2002,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1028
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
3,
4
] | 4 | true | Domain | YIPF3, N-terminal domain | YIPF3, N-terminal domain | YIPF3_N | 9 |
IPR060135 | 60,135 | Fumarate--diaminopropanoate ligase, C-terminal domain | DdaG_C | Domain | 137 | false | false | This entry represents the C-terminal domain of the fumarate--(S)-2,3- diaminopropanoate ligase (DdaG) found in Enterobacter agglomerans. While the full-length protein has characterised ligase activity in antibiotic biosynthesis, the specific function of this domain remains to be determined. The full-length DdaG protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27279"
] | [
"DdaG_C"
] | [
137
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151373"
] | [
"19807062"
] | [
"The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
137
] | 1 | [] | [] | 0 | true | Domain | Fumarate--diaminopropanoate ligase, C-terminal domain | Fumarate--diaminopropanoate ligase, C-terminal domain | DdaG_C | 3 |
IPR060136 | 60,136 | SPM domain | SPM | Domain | 3,259 | false | false | This self-processing module (SPM) domain is found in repeat-in-toxin (RTX) proteins. This domain is involved in an unique, calcium-dependent posttranslational modification known as 'clip-and-link' activity. It involves a rearrangement of the polypeptide backbone through a highly specific Ca2+-dependent autocatalytic cl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26745"
] | [
"SPM"
] | [
3259
] | 1 | [] | [] | [] | 0 | [
"6sjw",
"6sjx"
] | 2 | [
"PUB00162302"
] | [
"32184239"
] | [
"Structural Basis of Ca<sup>2+</sup>-Dependent Self-Processing Activity of Repeat-in-Toxin Proteins."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
3227,
12,
19,
1
] | 4 | [] | [] | 0 | true | Domain | SPM domain | SPM domain | SPM | 6 |
IPR060137 | 60,137 | DISC1, C-terminal domain | DISC1_C | Domain | 691 | false | false | This entry represents the C-terminal coiled coil/zipper domain of DISC1 (Disrupted in schizophrenia 1 protein). This domain contains a small helical region that is essential for protein-protein interactions. The domain is required for interaction with NDEL1 and PAFAH1B1 proteins [ , ]. DISC1 is involved in neurogenesis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28234"
] | [
"DISC1_C"
] | [
691
] | 1 | [] | [] | [] | 0 | [
"5yi4",
"6irr"
] | 2 | [
"PUB00059973",
"PUB00161902"
] | [
"10814723",
"14962739"
] | [
"Disruption of two novel genes by a translocation co-segregating with schizophrenia.",
"Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders."
] | [
2000,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Chordata"
] | [
2,
689
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
1,
4
] | 4 | true | Domain | DISC1, C-terminal domain | DISC1, C-terminal domain | DISC1_C | 9 |
IPR060138 | 60,138 | Adnp2-like, C2H2-type zinc finger | Znf-C2H2_Adnp2 | Domain | 2,479 | false | false | This C2H2-type zinc finger is found in human Activity-dependent neuroprotector homeobox protein (ADNP1) and Activity-dependent neuroprotector homeobox protein 2 (ADNP2), which may be involved in transcriptional regulation, play a role in neuronal function, and be involved in the protection of brain tissues from oxidati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26748"
] | [
"zf-C2H2_Adnp2"
] | [
2479
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088709",
"PUB00162432",
"PUB00162433"
] | [
"18179478",
"23071114",
"32533114"
] | [
"Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress.",
"Novel evolutionary-conserved role for the activity-dependent neuroprotective protein (ADNP) family that is important for erythropoiesis.",
"ADNP promotes neural differentiation by modulating Wnt/β-ca... | [
2008,
2012,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
2479
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
6,
14
] | 4 | true | Domain | Adnp2-like, C2H2-type zinc finger | Adnp2-like, C2H2-type zinc finger | Znf-C2H2_Adnp2 | 1 |
IPR060139 | 60,139 | VOZ, N-terminal domain | VOZ_N | Domain | 1,227 | false | false | This entry represents the N-terminal helical domain found in VOZ transcription factors. This domain is located N-terminal to the main VOZ DNA-binding domain in plant transcription factors VOZ1 and VOZ2 from Arabidopsis thaliana. VOZ proteins are vascular plant transcription factors that regulate flowering downstream of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28235"
] | [
"VOZ_N"
] | [
1227
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089391",
"PUB00162385"
] | [
"22904146",
"15295067"
] | [
"The phytochrome-interacting vascular plant one-zinc finger1 and VOZ2 redundantly regulate flowering in Arabidopsis.",
"VOZ; isolation and characterization of novel vascular plant transcription factors with a one-zinc finger from Arabidopsis thaliana."
] | [
2012,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1227
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
7,
17
] | 3 | true | Domain | VOZ, N-terminal domain | VOZ, N-terminal domain | VOZ_N | 9 |
IPR060140 | 60,140 | EsaA, C-terminal domain | EsaA_C | Domain | 630 | false | false | EsaA is a component of the type VII secretion system (Ess) found in Staphylococcus aureus and other bacterial species that is involved in bacterial secretion and virulence. EsaA is a multi-pass membrane protein with six transmembrane helices that provides a secretion platform across the cytoplasmic membrane. EsaA forms... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27280"
] | [
"EsaA_helical"
] | [
630
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161942"
] | [
"26785823"
] | [
"Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
630
] | 1 | [] | [] | 0 | true | Domain | EsaA, C-terminal domain | EsaA, C-terminal domain | EsaA_C | 8 |
IPR060141 | 60,141 | FAM111A/B, N-terminal domain | FAM111A_B_N | Domain | 981 | false | false | This entry represents the N-terminal domain found in human paralogues FAM111A and FAM111B and related proteins mainly from mammals. This domain has been shown to be essential for autoinhibition and dimerisation, both of which are critical for regulating the protease activity [ , ]. FAM111 proteins are serine proteases ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26749"
] | [
"FAM111_N"
] | [
981
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [
"PUB00161947",
"PUB00161948",
"PUB00161949",
"PUB00161950",
"PUB00161951",
"PUB00161952",
"PUB00161953",
"PUB00162491"
] | [
"24561620",
"33369867",
"38453899",
"39932783",
"23093934",
"32165630",
"37607234",
"38474092"
] | [
"Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.",
"FAM111A induces nuclear dysfunction in disease and viral restriction.",
"Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisom... | [
2014,
2021,
2024,
2025,
2012,
2020,
2023,
2024
] | 8 | [] | [] | 0 | 0 | null | [
"Citrobacter koseri",
"Eumetazoa",
"Lymphocystivirus"
] | [
1,
976,
4
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
7,
5,
4
] | 4 | true | Domain | FAM111A/B, N-terminal domain | FAM111A/B, N-terminal domain | FAM111A_B_N | 4 |
IPR060142 | 60,142 | NNF2, Ig-like domain | Ig-like_NNF2 | Domain | 167 | false | false | This entry represents an immunoglobulin-like (Ig-like) domain found in NNF2 proteins. NNF2 is a multi-pass membrane protein localised to the endoplasmic reticulum membrane with three transmembrane regions. The protein contains both luminal and cytoplasmic topological domains. This Ig-like domain is located within the l... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28268"
] | [
"Ig-like_NNF2"
] | [
167
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162058"
] | [
"18394190"
] | [
"Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
167
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | NNF2, Ig-like domain | NNF2, Ig-like domain | Ig-like_NNF2 | 6 |
IPR060143 | 60,143 | HfaA domain | HfaA_dom | Domain | 133 | false | false | This entry represents the HfaA domain found in holdfast attachment proteins from bacteria. This domain is composed of three short β-sheets. Members are approximately 147 amino acids in length. HfaA is involved in the attachment of the holdfast to the cell. The holdfast is a structure that allows the bacteria to firmly ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27294"
] | [
"HfaA"
] | [
133
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105470",
"PUB00162015"
] | [
"31061167",
"9973336"
] | [
"A Multiprotein Complex Anchors Adhesive Holdfast at the Outer Membrane of Caulobacter crescentus.",
"Cell cycle control of a holdfast attachment gene in Caulobacter crescentus."
] | [
2019,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"hydrothermal vent metagenome"
] | [
132,
1
] | 2 | [] | [] | 0 | true | Domain | HfaA domain | HfaA domain | HfaA_dom | 6 |
IPR060144 | 60,144 | MIP2, alpha-superhelix domain | MIP2_as | Domain | 648 | false | false | This entry represents an all-α domain found in MAG2-interacting protein 2 (MIP2) protein from Arabidopsis thaliana and related plant proteins. This domain is structurally similar to Sec39 domain ( ). MIP2 is essential for the proper maturation of seed storage proteins in plants [ ]. It forms a complex on the endoplasmi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26751"
] | [
"All-alpha_MIP2"
] | [
648
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00072936"
] | [
"24118572"
] | [
"MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
648
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
4,
6
] | 3 | true | Domain | MIP2, alpha-superhelix domain | MIP2, alpha-superhelix domain | MIP2_as | 9 |
IPR060145 | 60,145 | MJ1341, C-terminal domain | MJ1341_C | Domain | 98 | false | false | This entry represents the C-terminal domain of the uncharacterised protein MJ1341 found in methanogenic archaea. This domain is found across various methanogenic lineages including Methanobrevibacter, Methanosphaera, Methanobacterium, and Methanococcaceae. The full-length proteins are approximately 312 amino acids and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27296"
] | [
"MJ1341_C"
] | [
98
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriota",
"bioreactor metagenome"
] | [
97,
1
] | 2 | [] | [] | 0 | true | Domain | MJ1341, C-terminal domain | MJ1341, C-terminal domain | MJ1341_C | 4 |
IPR060147 | 60,147 | MIP2, C-terminal domain | MIP2_C | Domain | 675 | false | false | This entry represents the C-terminal domain found in MAG2-interacting protein 2 (MIP2) from Arabidopsis thaliana and related plant proteins. This domain is structurally similar to Sec39 domain ( ). MIP2 is essential for the proper maturation of seed storage proteins in plants [ ]. It forms a complex on the endoplasmic ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26752"
] | [
"MIP2_C"
] | [
675
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00072936"
] | [
"24118572"
] | [
"MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
675
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
4,
8
] | 3 | true | Domain | MIP2, C-terminal domain | MIP2, C-terminal domain | MIP2_C | 4 |
IPR060148 | 60,148 | YdcA | YdcA | Domain | 514 | false | false | This entry represents a conserved domain found in YdcA proteinsfrom Enterobacteriaceae. These proteins are approximately 57 amino acids in length and contain a signal peptide at the N-terminal region. YdcA proteins are found in species such as Escherichia coli and Shigella flexneri. The function of these proteins remai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27300"
] | [
"YdcA"
] | [
514
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"plant metagenome"
] | [
512,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YdcA | YdcA | YdcA | 9 |
IPR060149 | 60,149 | Cell division protein CdvB, C-terminal domain | CdvB_C | Domain | 90 | false | false | This entry represents the C-terminal helix-turn-helix (HTH) domain of the archaeal cell division protein CdvB. This domain is found in thermophilic archaea including Sulfolobaceae, Desulfurococcaceae, and Pyrodictiaceae. The specific function of this domain remains to be determined. CdvA, CdvB, and CdvC form a complex ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27303"
] | [
"CdvB_HTH"
] | [
90
] | 1 | [] | [] | [] | 0 | [
"2xvc"
] | 1 | [
"PUB00057104",
"PUB00083231"
] | [
"21255729",
"18987308"
] | [
"Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.",
"A unique cell division machinery in the Archaea."
] | [
2011,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Evansella vedderi"
] | [
89,
1
] | 2 | [] | [] | 0 | true | Domain | Cell division protein CdvB, C-terminal domain | Cell division protein CdvB, C-terminal domain | CdvB_C | 3 |
IPR060150 | 60,150 | SIS3, N-terminal domain | SIS3_N | Domain | 994 | false | false | This entry represents the N-terminal domain in E3 ubiquitin-protein ligase SIS3 from Arabidopsis thaliana and related plant proteins. SIS3 functions as a positive regulator of sugar signalling during the early stages of seedling development. It possess E3 ligase activity, which is crucial for the ubiquitination process... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26753"
] | [
"SIS3_N"
] | [
994
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097086"
] | [
"20147494"
] | [
"SUGAR-INSENSITIVE3, a RING E3 ligase, is a new player in plant sugar response."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
994
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
2,
12
] | 3 | true | Domain | SIS3, N-terminal domain | SIS3, N-terminal domain | SIS3_N | 6 |
IPR060151 | 60,151 | UU051, N-terminal domain | UU051_N | Domain | 155 | false | false | This entry represents the N-terminal domain of UU051. The specific function of this N-terminal domain remains to be determined. UU051 proteins are found in Ureaplasma and related species from Mycoplasmoidales and Mycoplasmatales. The full-length UU051 protein is approximately 170 amino acids. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27304"
] | [
"UU051_N"
] | [
155
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
155
] | 1 | [] | [] | 0 | true | Domain | UU051, N-terminal domain | UU051, N-terminal domain | UU051_N | 1 |
IPR060152 | 60,152 | UU051 | UU051 | Family | 156 | false | false | UU051 proteins are found in Ureaplasma and related species from Mycoplasmoidales and Mycoplasmatales. The full-length UU051 protein is approximately 170 amino acids. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045935"
] | [
"MSC_0621_epsi"
] | [
156
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154868"
] | [
"22685606"
] | [
"Specific evolution of F1-like ATPases in mycoplasmas."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
156
] | 1 | [] | [] | 0 | true | Family | UU051 | UU051 | UU051 | 4 |
IPR060153 | 60,153 | XkdV/YomR, N-terminal domain | XkdV/YomR_N | Domain | 290 | false | false | This entry represents the N-terminal domain of XkdV proteins found in bacteria. XkdV proteins are associated with phage-like elements such as PBSX in Bacillus subtilis. The full-length XkdV protein is approximately 687 amino acids. The specific function of this domain remains to be determined. This entry also represent... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27308"
] | [
"XkdV_N"
] | [
290
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli",
"Viruses"
] | [
254,
36
] | 2 | [] | [] | 0 | true | Domain | XkdV/YomR, N-terminal domain | XkdV/YomR, N-terminal domain | XkdV/YomR_N | 3 |
IPR060155 | 60,155 | MJ0786, N-terminal domain | MJ0786_N | Domain | 121 | false | false | This entry represents the N-terminal domain of the MJ0786 found in methanogenic archaea. This domain is found across various methanogenic lineages including Methanosarcinaceae, Methanotrichaceae, Methanothrix, and Methanococcales. The full-length proteins are approximately 186 amino acids and contain two domains. The f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27317"
] | [
"MJ0786_N"
] | [
121
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
121
] | 1 | [] | [] | 0 | true | Domain | MJ0786, N-terminal domain | MJ0786, N-terminal domain | MJ0786_N | 7 |
IPR060157 | 60,157 | YnaG | YnaG | Domain | 212 | false | false | This entry represents YnaG uncharacterised membrane proteins found in Bacillus and related Gram-positive bacteria. YnaG proteins are typically around 90 amino acids in length and contain three predicted transmembrane helices. The proteins are localised to the cell membrane and adopt a multi-pass membrane topology. YnaG... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27331"
] | [
"YnaG"
] | [
212
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati"
] | [
212
] | 1 | [] | [] | 0 | true | Domain | YnaG | YnaG | YnaG | 6 |
IPR060158 | 60,158 | Meiosis 1 arrest protein, N-terminal domain | M1AP_N | Domain | 1,011 | false | false | This entry represents the N-terminal domain of the meiosis 1 arrest protein (M1AP). This domain adopts a von Willebrand factor type A (VWA) fold. The specific function of this N-terminal domain remains to be determined. Meiosis 1 arrest protein (M1AP), also known as spermatogenesis-associated protein 37 (Spata37), is r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28287"
] | [
"M1AP_N"
] | [
1011
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00079155",
"PUB00162146"
] | [
"23269666",
"32673564"
] | [
"Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.",
"Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility."
] | [
2013,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1011
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
3,
1,
2
] | 4 | true | Domain | Meiosis 1 arrest protein, N-terminal domain | Meiosis 1 arrest protein, N-terminal domain | M1AP_N | 4 |
IPR060159 | 60,159 | Biotrophy-associated secreted protein 2, conserved domain | BAS2_dom | Domain | 981 | false | false | This entry represents a conserved domain found in biotrophy-associated secreted protein 2 (BAS2) proteins. In some members, this domain appears three times. These are small secreted effector proteins of approximately 100 amino acids found in plant pathogenic fungi, particularly in the rice blast fungus Pyricularia oryz... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28293"
] | [
"BAS2"
] | [
981
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161823"
] | [
"19357089"
] | [
"Interaction transcriptome analysis identifies Magnaporthe oryzae BAS1-4 as Biotrophy-associated secreted proteins in rice blast disease."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Fungi",
"Pendulispora"
] | [
979,
2
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Biotrophy-associated secreted protein 2, conserved domain | Biotrophy-associated secreted protein 2, conserved domain | BAS2_dom | 5 |
IPR060161 | 60,161 | Receptor-type tyrosine-protein phosphatase O, N-terminal domain | PTPRO_N | Domain | 1,236 | false | false | This entry represents the N-terminal domain of human receptor-type tyrosine protein phosphatase O (PTPRO) and related proteins from vertebrates. PTPRO is characterised by its tyrosine phosphatase activity. It plays a crucial role in regulating the relationship between glomerular pressure and filtration rate, which is a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26755"
] | [
"PTPRO_N"
] | [
1236
] | 1 | [
"REACTOME"
] | [
"R-HSA-9034015"
] | [
"REACTOME:R-HSA-9034015"
] | 1 | [] | 0 | [
"PUB00045909",
"PUB00161233"
] | [
"19167335",
"11086029"
] | [
"Large-scale structural analysis of the classical human protein tyrosine phosphatome.",
"Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate."
] | [
2009,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1236
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
5,
4,
4
] | 4 | true | Domain | Receptor-type tyrosine-protein phosphatase O, N-terminal domain | Receptor-type tyrosine-protein phosphatase O, N-terminal domain | PTPRO_N | 5 |
IPR060162 | 60,162 | TP_0481, C-terminal domain | TP_0481_C | Domain | 72 | false | false | This entry represents the C-terminal domain of TP_0481 proteins found in Treponema and related spirochaetes. The full-length protein is 477 amino acids and contains a single transmembrane helix at positions 107-129. TP_0481 is a membrane protein found in Treponema pallidum, the causative agent of syphilis. The function... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27335"
] | [
"TP_0481_C"
] | [
72
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadati"
] | [
3,
69
] | 2 | [] | [] | 0 | true | Domain | TP_0481, C-terminal domain | TP_0481, C-terminal domain | TP_0481_C | 5 |
IPR060163 | 60,163 | Mitogen-activated protein kinase kinase kinase 1, TOG domain | TOG_MAP3K1 | Domain | 1,052 | false | false | This entry represents the TOG domain in Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), a key signalling enzyme in the MAP kinase pathway, functioning at the top tier of the kinase cascade that regulates cellular responses to various external stimuli [ ]. It activates the ERK and JNK kinase pathways by phosp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28295"
] | [
"TOG_MAP3K1"
] | [
1052
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.25",
"R-HSA-166058",
"R-HSA-2871796",
"R-HSA-933542",
"R-HSA-975138",
"R-HSA-975871",
"R-MMU-166058",
"R-MMU-2871796",
"R-MMU-975138",
"R-MMU-975871",
"R-RNO-166058",
"R-RNO-2871796",
"R-RNO-975138",
"R-RNO-975871"
] | [
"EC:2.7.11.25",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-2871796",
"REACTOME:R-HSA-933542",
"REACTOME:R-HSA-975138",
"REACTOME:R-HSA-975871",
"REACTOME:R-MMU-166058",
"REACTOME:R-MMU-2871796",
"REACTOME:R-MMU-975138",
"REACTOME:R-MMU-975871",
"REACTOME:R-RNO-166058",
"REACTOME:R-RNO-2871796",
... | 14 | [
"6whb"
] | 1 | [
"PUB00151671",
"PUB00162340"
] | [
"32817551",
"9808624"
] | [
"A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.",
"JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension."
] | [
2020,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1052
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
9
] | 4 | true | Domain | Mitogen-activated protein kinase kinase kinase 1, TOG domain | Mitogen-activated protein kinase kinase kinase 1, TOG domain | TOG_MAP3K1 | 1 |
IPR060164 | 60,164 | Maintenance of telomere capping protein 4, N-terminal domain | MTC4_N | Domain | 1,165 | false | false | This entry represents the N-terminal domain of maintenance of telomere capping protein 4 (MTC4). MTC4 is a 694 amino acid protein found primarily in fungi, particularly in the Ascomycota phylum. The full-length MTC4 protein is involved in telomere maintenance and capping functions in Saccharomyces cerevisiae [ ]. This ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28296"
] | [
"MTC4_N"
] | [
1165
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00059200"
] | [
"18845848"
] | [
"A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1165
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Maintenance of telomere capping protein 4, N-terminal domain | Maintenance of telomere capping protein 4, N-terminal domain | MTC4_N | 4 |
IPR060165 | 60,165 | DALR, N-terminal domain | DALR_N | Domain | 813 | false | false | This entry represents the N-terminal domain in DALR proteins from animals. DALR is involved in the process of tRNA methylation. It plays a crucial role in the recognition and targeting of specific tRNA substrates, namely tRNA(Arg)(CCU) and tRNA(Arg)(UCU), for N(3)-methylcytidine modification. This modification is facil... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26758"
] | [
"DALR_N"
] | [
813
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161564"
] | [
"32427860"
] | [
"DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
813
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2,
3
] | 4 | true | Domain | DALR, N-terminal domain | DALR, N-terminal domain | DALR_N | 6 |
IPR060166 | 60,166 | AcfD, helical domain | AcfD_helical | Domain | 352 | false | false | This domain is found in Accessory colonization factor AcfD from Vibrio cholerae and its homologue from E.coli. AcfD (also known as YghJ) from E.coli is a secreted, cell surface-associated metalloprotease, especially prevalent and highly expressed in pathogenic types [ ]. It contains an M60-like metalloprotease domain, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26759"
] | [
"AcfD_helical"
] | [
352
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105495"
] | [
"28212863"
] | [
"YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mouse ileal loop."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"metagenomes"
] | [
350,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | AcfD, helical domain | AcfD, helical domain | AcfD_helical | 4 |
IPR060167 | 60,167 | CCDC3, C-terminal | CCDC3_C | Domain | 996 | false | false | This entry represents the C-terminal coiled-coil domain of coiled-coil domain-containing protein 3 (CCDC3). CCDC3 is found across vertebrate species and forms homodimers through this coiled-coil region [ ]. The full-length CCDC3 protein negatively regulates TNF-alpha-induced pro-inflammatory responses in endothelial ce... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28297"
] | [
"CCDC3_C"
] | [
996
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090806",
"PUB00161859",
"PUB00161860"
] | [
"25193116",
"20043878",
"25605713"
] | [
"Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation.",
"Identification of a new secretory factor, CCDC3/Favine, in adipocytes and endothelial cells.",
"Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in lipid accumulation.... | [
2014,
2010,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
996
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
1,
2
] | 4 | true | Domain | CCDC3, C-terminal | CCDC3, C-terminal | CCDC3_C | 6 |
IPR060168 | 60,168 | Whi3/4, N-terminal domain | Whi3/4_N | Domain | 186 | false | false | This entry represents an RRM domain found N-terminal in a group of proteins including yeast Scw1, Whi3, and Whi4. Scw1 is a cytoplasmic RNA-binding protein involved in septation and cell wall structure in fission yeast. It may act as an inhibitor of septum formation. Its RRM shares sequence similarity with those of Whi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26763"
] | [
"Whi3-like_N"
] | [
186
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00128538"
] | [
"11290704"
] | [
"Isolation and characterization of WHI3, a size-control gene of Saccharomyces cerevisiae."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Ascomycota"
] | [
186
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
2
] | 2 | true | Domain | Whi3/4, N-terminal domain | Whi3/4, N-terminal domain | Whi3/4_N | 2 |
IPR060169 | 60,169 | MJ0786, C-terminal domain | MJ0786_C | Domain | 123 | false | false | This entry represents the C-terminal domain of MJ0786 uncharacterised proteins found in methanogenic archaea. This domain is found across various methanogenic lineages including Methanosarcinaceae, Methanobacteriaceae, Methanosphaera, and Methanococcales. The function of this C-terminal domain remains to be determined.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27336"
] | [
"MJ0786_C"
] | [
123
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
123
] | 1 | [] | [] | 0 | true | Domain | MJ0786, C-terminal domain | MJ0786, C-terminal domain | MJ0786_C | 9 |
IPR060171 | 60,171 | Stationary phase protein 5, C-terminal domain | SPG5_C | Domain | 1,147 | false | false | This entry represents the C-terminal domain of stationary phase protein 5 (SPG5). This domain is found in proteins of approximately 370 amino acids present across fungal species, particularly in the Ascomycota phylum. The full-length SPG5 protein is required for survival at high temperature during stationary phase and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28298"
] | [
"SPG5_C"
] | [
1147
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074983"
] | [
"15456898"
] | [
"Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1147
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Stationary phase protein 5, C-terminal domain | Stationary phase protein 5, C-terminal domain | SPG5_C | 2 |
IPR060172 | 60,172 | VSIG10L2, N-terminal immunoglobulin-like domain | Ig_VSIG10L2_N | Domain | 269 | false | false | This immunoglobulin-like (Ig-like) domain is found at the N-terminal end of human V-set and immunoglobulin domain-containing protein 10-like 2 (VSIG10L2) and similar sequences. Its specific function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28299"
] | [
"Ig_VSIG10L2_N"
] | [
269
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
269
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1
] | 3 | true | Domain | VSIG10L2, N-terminal immunoglobulin-like domain | VSIG10L2, N-terminal immunoglobulin-like domain | Ig_VSIG10L2_N | 7 |
IPR060173 | 60,173 | Uncharacterised protein FLJ43738-like domain | FLJ43738-like_dom | Domain | 1,186 | false | false | This entry represents a central domain of uncharacterised protein FLJ43738. This domain is found in proteins of approximately 570 amino acids present across eukaryotic species, mainly vertebrates and arthropods. The C-terminal region contains a disordered region enriched in basic residues. The protein is expressed in h... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28302"
] | [
"FLJ43738_C"
] | [
1186
] | 1 | [] | [] | [] | 0 | [
"7n6g"
] | 1 | [
"PUB00161964"
] | [
"18579725"
] | [
"Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1186
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2,
2
] | 4 | true | Domain | Uncharacterised protein FLJ43738-like domain | Uncharacterised protein FLJ43738-like domain | FLJ43738-like_dom | 6 |
IPR060174 | 60,174 | SGR6, HEAT repeat domain | HEAT_SGR6 | Domain | 836 | false | false | This is a region of HEAT repeats found in Protein SHOOT GRAVITROPISM 6 from Arabidopsis thaliana (SGR6) and similar proteins. SGR6 is involved in inflorescence stems gravitropism, by modulating vacuolar membrane dynamics in gravity-sensing cells during the amyloplast sedimentation process [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26767"
] | [
"HEAT_SGR6"
] | [
836
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098263",
"PUB00162007"
] | [
"24486761",
"9210330"
] | [
"A unique HEAT repeat-containing protein SHOOT GRAVITROPISM6 is involved in vacuolar membrane dynamics in gravity-sensing cells of Arabidopsis inflorescence stem.",
"Mutations in the SGR4, SGR5 and SGR6 loci of Arabidopsis thaliana alter the shoot gravitropism."
] | [
2014,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
836
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
3,
20
] | 3 | true | Domain | SGR6, HEAT repeat domain | SGR6, HEAT repeat domain | HEAT_SGR6 | 4 |
IPR060175 | 60,175 | Uncharacterised protein FLJ43738-like, N-terminal domain | FLJ43738-like_N | Domain | 936 | false | false | This entry represents the N-terminal domain of uncharacterised protein FLJ43738. This domain is found in proteins of approximately 570 amino acids present across eukaryotic species. The N-terminal region contains a disordered region enriched in basic residues. The protein is expressed in human testis and has been ident... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28322"
] | [
"FLJ43738_N"
] | [
936
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
936
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
1,
2
] | 4 | true | Domain | Uncharacterised protein FLJ43738-like, N-terminal domain | Uncharacterised protein FLJ43738-like, N-terminal domain | FLJ43738-like_N | 7 |
IPR060177 | 60,177 | Fanconi anaemia group B protein, middle domain | FANCB_middle | Domain | 989 | false | false | This entry represents a middle domain of the Fanconi anaemia group B protein (FANCB). The specific function of this middle domain remains to be determined. FANCB (also known as FAAP95) is a DNA repair protein required for FANCD2 ubiquitination that is a component of the Fanconi anemia (FA) core complex [ ]. The FA core... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28312"
] | [
"FANCB_middle"
] | [
989
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 6 | [
"PUB00061939",
"PUB00073779",
"PUB00078482",
"PUB00078483",
"PUB00078485",
"PUB00078487",
"PUB00078488",
"PUB00078489",
"PUB00096995"
] | [
"15502827",
"16357213",
"16720839",
"24910428",
"15611632",
"26123487",
"26658157",
"19264559",
"16116422"
] | [
"X-linked inheritance of Fanconi anemia complementation group B.",
"The Fanconi Anemia/BRCA pathway: new faces in the crowd.",
"Evidence for subcomplexes in the Fanconi anemia pathway.",
"Modularized functions of the Fanconi anemia core complex.",
"New advances in the DNA damage response network of Fanconi ... | [
2004,
2005,
2006,
2014,
2005,
2015,
2015,
2009,
2005
] | 9 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
989
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
4,
2
] | 4 | true | Domain | Fanconi anaemia group B protein, middle domain | Fanconi anaemia group B protein, middle domain | FANCB_middle | 5 |
IPR060179 | 60,179 | Interferon-induced very large GTPase 1, C-terminal | GVIN1_C | Domain | 3,450 | false | false | This domain is found at the C-terminal of mouse Interferon-induced very large GTPase 1 (GVIN1 or VLIG-1) and similar proteins mainly found in vertebrates. Members of this group play a role in conserved immune functions [ ]. This domain is predicted to adopt a mainly α configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26772"
] | [
"GVIN1_C"
] | [
3450
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161632"
] | [
"19369598"
] | [
"The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Cyanophyceae",
"Eukaryota"
] | [
4,
3446
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
50,
1,
3,
2
] | 4 | true | Domain | Interferon-induced very large GTPase 1, C-terminal | Interferon-induced very large GTPase 1, C-terminal | GVIN1_C | 7 |
IPR060180 | 60,180 | Up-regulator of cell proliferation-like, N-terminal | URGCP_N | Domain | 2,849 | false | false | This domain is found in functionally diverse proteins such as Up-regulator of cell proliferation (URGCP), Interferon-induced very large GTPase 1 and Caspase recruitment domain-containing protein 6. This domain is predicted to adopt an all α structure. URGCP is involved in cell cycle progression through the regulation o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26773"
] | [
"URGCP_N"
] | [
2849
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160385",
"PUB00162369"
] | [
"17217616",
"12082552"
] | [
"Enhanced cell survival of gastric cancer cells by a novel gene URG4.",
"Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival."
] | [
2006,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Cyanophyceae",
"Eukaryota"
] | [
4,
2845
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
10,
10,
14
] | 4 | true | Domain | Up-regulator of cell proliferation-like, N-terminal | Up-regulator of cell proliferation-like, N-terminal | URGCP_N | 7 |
IPR060181 | 60,181 | Phosphodiesterase 8, third domain | PDE8_3rd | Domain | 2,822 | false | false | This entry represents a small bihelical domain that forms the third domain in phosphodiesterase 8A (PDE8A) and 8B (PDE8B). PDE8A and PDE8B are high affinity cAMP-specific phosphodiesterases that hydrolyse the second messenger cAMP. These enzymes are insensitive to the non-selective phosphodiesterase inhibitor IBMX [ , ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28324"
] | [
"PDE8_3rd"
] | [
2822
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.1.4.53",
"R-HSA-418555",
"R-MMU-418555"
] | [
"EC:3.1.4.53",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-418555"
] | 3 | [] | 0 | [
"PUB00051657",
"PUB00163219",
"PUB00163220"
] | [
"18983167",
"23509299",
"9671792"
] | [
"Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.",
"Phosphodiesterase-8A binds to and regulates Raf-1 kinase.",
"Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase."
] | [
2008,
2013,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2822
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
13,
15
] | 4 | true | Domain | Phosphodiesterase 8, third domain | Phosphodiesterase 8, third domain | PDE8_3rd | 1 |
IPR060182 | 60,182 | RBM43, KH-domain type I | KH_I_RBM43 | Domain | 686 | false | false | This entry represents the type I KH domain in RNA-binding protein 43 (RBM43) mostly found in mammals. RBM43 is induced by inflammatory cytokines and suppresses mitochondrial biogenesis in a PGC1alpha-dependent manner [ ]. This domain is often found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26774"
] | [
"KH_I_RBM43"
] | [
686
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162109"
] | [
"39965564"
] | [
"RBM43 controls PGC1α translation and a PGC1α-STING signaling axis."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
686
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
1,
4
] | 4 | true | Domain | RBM43, KH-domain type I | RBM43, KH-domain type I | KH_I_RBM43 | 1 |
IPR060184 | 60,184 | Baseplate J-like, N-terminal domain | Baseplate_J_N | Domain | 5,318 | false | false | This domain is found at the N-terminal of Bacteriophage P2 Baseplate protein J, which may be part of the wedges of the baseplate. This entry also includes a number of bacterial homologues, which are thought to have been horizontally transferred. This domain is often found associated with and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26776"
] | [
"Baseplate_J_N"
] | [
5318
] | 1 | [] | [] | [] | 0 | [
"6u5b",
"6u5k"
] | 2 | [
"PUB00008577",
"PUB00161589"
] | [
"7483254",
"22297511"
] | [
"Bacteriophage P2: genes involved in baseplate assembly.",
"Contractile tail machines of bacteriophages."
] | [
1995,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5130,
26,
153,
9
] | 4 | [] | [] | 0 | true | Domain | Baseplate J-like, N-terminal domain | Baseplate J-like, N-terminal domain | Baseplate_J_N | 8 |
IPR060185 | 60,185 | Beta-trefoil domain, fungi | Beta_trefoil_fun | Domain | 2,031 | false | false | This domain is mostly found in single domain fungal proteins, although some members have other domains. It may have a β-trefoil fold. The β-trefoil fold consists of six β-hairpins arranged in threefold symmetry around a central axis. This family is primarily found in ascomycota. The function of these proteins remains t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28325"
] | [
"Beta_trefoil_fun"
] | [
2031
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2031
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Beta-trefoil domain, fungi | Beta-trefoil domain, fungi | Beta_trefoil_fun | 4 |
IPR060186 | 60,186 | Condensin-2 complex subunit D3-like, N-terminal domain | NCAPD3_N | Domain | 1,727 | false | false | This domain is found at the N-terminal of human Condensin-2 complex subunit D3 (NCAPD3) and similar proteins, including Condensin-2 complex subunit hcp-6 from Caenorhabditis elegans. NCAPD3 is a regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26777"
] | [
"NCAPD3_N"
] | [
1727
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2299718",
"R-HSA-2299718",
"R-MMU-2299718"
] | [
"REACTOME:R-CEL-2299718",
"REACTOME:R-HSA-2299718",
"REACTOME:R-MMU-2299718"
] | 3 | [
"9f5w"
] | 1 | [
"PUB00014711",
"PUB00056240",
"PUB00100765",
"PUB00162006"
] | [
"12080088",
"14532007",
"27737959",
"15767665"
] | [
"Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment.",
"Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.",
"Mutations in genes encoding condensin complex proteins cause microcephaly th... | [
2002,
2003,
2016,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1727
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
9,
5,
3
] | 5 | true | Domain | Condensin-2 complex subunit D3-like, N-terminal domain | Condensin-2 complex subunit D3-like, N-terminal domain | NCAPD3_N | 9 |
IPR060187 | 60,187 | TOE-2, middle domain | TOE2_M | Domain | 56 | false | false | This entry represents a middle domain of the target of ERK kinase mpk-1 (TOE-2) from nematode species. The function of this domain remains to be determined. TOE-2 is involved in promoting asymmetric cell division and fate assignment in the Q neuroblast lineage, functioning as a downstream target of MAP kinase mpk-1 [ ]... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27592"
] | [
"TOE2_M"
] | [
56
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8980692",
"R-CEL-9013026",
"R-CEL-9013148",
"R-CEL-9013149",
"R-CEL-9013404",
"R-CEL-9013405",
"R-CEL-9013406",
"R-CEL-9013408",
"R-CEL-9013409",
"R-CEL-9013420",
"R-CEL-9013423",
"R-CEL-9013424",
"R-CEL-9035034"
] | [
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-CEL-9013148",
"REACTOME:R-CEL-9013149",
"REACTOME:R-CEL-9013404",
"REACTOME:R-CEL-9013405",
"REACTOME:R-CEL-9013406",
"REACTOME:R-CEL-9013408",
"REACTOME:R-CEL-9013409",
"REACTOME:R-CEL-9013420",
"REACTOME:R-CEL-9013423",
"REACTOM... | 13 | [] | 0 | [
"PUB00162339"
] | [
"24961802"
] | [
"The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
56
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | TOE-2, middle domain | TOE-2, middle domain | TOE2_M | 9 |
IPR060189 | 60,189 | ZNF804A-like/GPATCH8, small beta-sheet domain | ZNF804A-like/GPATCH8_beta | Domain | 2,895 | false | false | This entry represents a small β sheet domain found in ZNF804A and similar animal proteins including G patch domain-containing protein 8 (GPATCH8). ZNF804A is localised to neuronal compartments, including dendritic spines, growth cones and synapses. ZNF804A protein is involved in positive regulation of neuron projection... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27597"
] | [
"ZNF804A_beta"
] | [
2895
] | 1 | [
"REACTOME"
] | [
"R-HSA-212436"
] | [
"REACTOME:R-HSA-212436"
] | 1 | [] | 0 | [
"PUB00162438",
"PUB00163222",
"PUB00163223"
] | [
"38216065",
"21594610",
"38688280"
] | [
"Impulsivity and aggression in alcohol withdrawal syndrome is modulated by the interaction of ZNF804A and mTOR polymorphism.",
"Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8.",
"GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malig... | [
2024,
2011,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2895
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
36,
6,
6,
9
] | 4 | true | Domain | ZNF804A-like/GPATCH8, small beta-sheet domain | ZNF804A-like/GPATCH8, small beta-sheet domain | ZNF804A-like/GPATCH8_beta | 7 |
IPR060190 | 60,190 | Glutamate-rich protein 1, C-terminal domain | ERICH1_C | Domain | 963 | false | false | This entry represents the C-terminal domain of glutamate-rich protein 1 (ERICH1). The function of this C-terminal domain remains to be determined. ERICH1 protein contains extensive disordered regions enriched in various residue types including acidic and basic residues. The protein undergoes phosphorylation at multiple... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28319"
] | [
"ERICH1_C"
] | [
963
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
963
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
3,
2
] | 4 | true | Domain | Glutamate-rich protein 1, C-terminal domain | Glutamate-rich protein 1, C-terminal domain | ERICH1_C | 9 |
IPR060191 | 60,191 | Semaphorin 4F, inmunnoglobulin-like domain | Ig_Sema4F | Domain | 669 | false | false | This is the immunoglobulin-like (Ig-like) domain found in Semaphorin-4F (SemaF4) and related proteins. [ ]. Semaphorins are a large and diverse family of proteins, widely expressed across divergent animal phyla, divided into eight classes (1-7 and V) which are structurally and functionally conserved. These proteins are... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28320"
] | [
"Ig_Sema4F"
] | [
669
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9696264",
"R-MMU-9696264",
"R-RNO-9696264"
] | [
"REACTOME:R-HSA-9696264",
"REACTOME:R-MMU-9696264",
"REACTOME:R-RNO-9696264"
] | 3 | [] | 0 | [
"PUB00063285",
"PUB00063288",
"PUB00063292",
"PUB00099007",
"PUB00099008",
"PUB00101801",
"PUB00152591"
] | [
"22157652",
"22897846",
"16584533",
"11483650",
"21945643",
"19056885",
"10051670"
] | [
"Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer.",
"Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.",
"The semaphorins.",
"Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95.",
"Expression of Semaphorin 4F in neur... | [
2012,
2012,
2006,
2001,
2012,
2008,
1999
] | 7 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
669
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3
] | 3 | true | Domain | Semaphorin 4F, inmunnoglobulin-like domain | Semaphorin 4F, inmunnoglobulin-like domain | Ig_Sema4F | 1 |
IPR060192 | 60,192 | AAPxQ domain | AAPxQ | Domain | 3,544 | false | false | This domain is found in Magnesium-chelatase subunit ChlD and related proteins. This domain contains a highly conserved AAPxQ sequence motif after which it was named. ChlD is a crucial component of the magnesium chelatase enzyme complex, which catalyses the insertion of magnesium into protoporphyrin IX - a critical step... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26791"
] | [
"AAPxQ"
] | [
3544
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"6.6.1.1",
"PWY-5531",
"PWY-7159"
] | [
"EC:6.6.1.1",
"METACYC:PWY-5531",
"METACYC:PWY-7159"
] | 3 | [] | 0 | [
"PUB00161778"
] | [
"31164400"
] | [
"The ChlD subunit links the motor and porphyrin binding subunits of magnesium chelatase."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
172,
2554,
800,
18
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
2,
6
] | 3 | true | Domain | AAPxQ domain | AAPxQ domain | AAPxQ | 1 |
IPR060193 | 60,193 | LysM11, alpha/beta domain | LysM11_ab | Domain | 909 | false | false | This domain is found towards the C terminus of LysM11 from Penicillium expansum (also known as PeLysM11) and related fungal proteins. PeLysM11 was shown to play a regulatory role in the fungal virulence [ ]. Besides the LysM domain, this protein contains a GH18-like domain followed by the domain represented by this ent... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26794"
] | [
"LysM11_ab"
] | [
909
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154508"
] | [
"32656702"
] | [
"Multiple transcriptomic analyses and characterization of pathogen-related core effectors and LysM family members reveal their differential roles in fungal growth and pathogenicity in Penicillium expansum."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
909
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | LysM11, alpha/beta domain | LysM11, alpha/beta domain | LysM11_ab | 3 |
IPR060194 | 60,194 | Hook protein-like, calponin-homology domain | CH_HOOK_api | Domain | 88 | false | false | This entry represents an N-terminal calponin homology domain found in apicomplexan hook like proteins. The CH domain of other HOOK proteins mediates binding to microtubules. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26801"
] | [
"CH_HOOK_api"
] | [
88
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Apicomplexa"
] | [
88
] | 1 | [] | [] | 0 | true | Domain | Hook protein-like, calponin-homology domain | Hook protein-like, calponin-homology domain | CH_HOOK_api | 5 |
IPR060195 | 60,195 | FF domain, fungal | FF_fungal | Domain | 406 | false | false | This entry represents an FF domain found in fungal proteins. The members of this family are functionally uncharacterised. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26803"
] | [
"FF_fungal"
] | [
406
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
406
] | 1 | [] | [] | 0 | true | Domain | FF domain, fungal | FF domain, fungal | FF_fungal | 3 |
IPR060196 | 60,196 | Pre-mRNA-splicing factor, FF domain | FF_URN1 | Domain | 74 | false | false | This entry represents an FF-like domain found in the yeast Pre-mRNA-splicing factor URN1 protein found in Saccharomycetes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26804"
] | [
"FF_URN1"
] | [
74
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057210",
"PUB00161960"
] | [
"21386897",
"23560879"
] | [
"Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.",
"Rapid screening of yeast mutants with reporters identifies new splicing phenotypes."
] | [
2011,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
74
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Pre-mRNA-splicing factor, FF domain | Pre-mRNA-splicing factor, FF domain | FF_URN1 | 3 |
IPR060197 | 60,197 | YopL/AimP-like | YopL_AimP | Family | 25 | false | false | The YopL AimP family is involved in the latency-replication switch system of bacteriophages, which determines whether to enter a lytic or lysogenic cycle upon infection. The family includes proteins that play a role in viral communication and decision-making processes. Specifically, the AimP protein is a peptide releas... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF033802",
"PF26811"
] | [
"AimP_fam",
"YopL_AimP"
] | [
24,
24
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105338"
] | [
"28099413"
] | [
"Communication between viruses guides lysis-lysogeny decisions."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillaceae",
"Spbetavirus"
] | [
23,
2
] | 2 | [] | [] | 0 | true | Family | YopL/AimP-like | YopL/AimP-like | YopL_AimP | 5 |
IPR060198 | 60,198 | TP_0126/TP_0733/BB_0027 | TP_0126-like | Domain | 150 | false | false | This entry represents TP_0126, TP_0733 and BB_0027 proteins found in Treponema and related spirochaetes. The proteins adopt a β-barrel fold structure and belong to the OmpA-like. TP_0126 is found in Treponema pallidum, the causative agent of syphilis, and shows similarity to TP_0733. The proteins are classified in the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27340"
] | [
"TP_0126"
] | [
150
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162494"
] | [
"18509523"
] | [
"The binary protein interactome of Treponema pallidum--the syphilis spirochete."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
147,
3
] | 2 | [] | [] | 0 | true | Domain | TP_0126/TP_0733/BB_0027 | TP_0126/TP_0733/BB_0027 | TP_0126-like | 1 |
IPR060199 | 60,199 | LcnD/ComB-like, N-terminal domain | LcnD/ComB-like_N | Domain | 686 | false | false | This entry represents the N-terminal domain of ComB proteins found in Gram-positive bacteria. The domain adopts a helical fold structure. While the full-length protein has demonstrated roles in competence induction, the specific function of this N-terminal domain remains to be determined. This entry also represents oth... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27342"
] | [
"ComB_N"
] | [
686
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00034682",
"PUB00087441",
"PUB00087450",
"PUB00087451",
"PUB00161880"
] | [
"16205711",
"7551032",
"15019729",
"11731132",
"7883181"
] | [
"Bacteriocins: developing innate immunity for food.",
"Mesentericin Y105 gene clusters in Leuconostoc mesenteroides Y105.",
"Differences in mesentericin secretion systems from two Leuconostoc strains.",
"Proteins of the lactococcin A secretion system: lcnD encodes two in-frame proteins.",
"Competence for ge... | [
2005,
1995,
2004,
2001,
1995
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
686
] | 1 | [] | [] | 0 | true | Domain | LcnD/ComB-like, N-terminal domain | LcnD/ComB-like, N-terminal domain | LcnD/ComB-like_N | 7 |
IPR060200 | 60,200 | Myomesin-1-3, immunoglobulin-like domain | Ig_MYOM1-3 | Domain | 4,868 | false | false | This is one of the multiple immunoglobulin-like (Ig-like) domains found in human Myomesin-1-3 (MYOM1-3) and similar sequences. MYOM1-3 are a major component of the vertebrate myofibrillar M band. They bind myosin, titin, and light meromyosin. This binding is dose dependent [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28321"
] | [
"Ig_MYOM1"
] | [
4868
] | 1 | [] | [] | [] | 0 | [
"2y23"
] | 1 | [
"PUB00163196"
] | [
"26060189"
] | [
"Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies."
] | [
2015
] | 1 | [
"IPR007110"
] | [] | 1 | 0 | 1 | [
"Chordata",
"Pantoea vagans"
] | [
4866,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
22,
6,
6,
12
] | 4 | true | Domain | Myomesin-1-3, immunoglobulin-like domain | Myomesin-1-3, immunoglobulin-like domain | Ig_MYOM1-3 | 8 |
IPR060201 | 60,201 | Leucine-rich repeat-containing protein 43, N-terminal domain | LRRC43_N | Domain | 934 | false | false | This entry represents the N-terminal domain of leucine-rich repeat-containing protein 43 (LRRC43). The specific function of this N-terminal domain remains to be determined. Leucine-rich repeat-containing protein 43 (LRRC43) is found in mammals and contains multiple leucine-rich repeats. The protein is expressed in test... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28328"
] | [
"LRRC43_N"
] | [
934
] | 1 | [] | [] | [] | 0 | [
"9ijj"
] | 1 | [
"PUB00162133"
] | [
"21677750"
] | [
"A conditional knockout resource for the genome-wide study of mouse gene function."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
934
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
5
] | 3 | true | Domain | Leucine-rich repeat-containing protein 43, N-terminal domain | Leucine-rich repeat-containing protein 43, N-terminal domain | LRRC43_N | 8 |
IPR060202 | 60,202 | MJ0207/MJ1342 | MJ0207-like | Domain | 41 | false | false | This entry represents MJ0207 and MJ1342 uncharacterised proteins found predominantly in thermophilic archaea and some bacteria. This entry is found in Thermofilaceae, Methanocaldococcaceae, Desulfurococcaceae, and Ignicoccus, with some bacterial members. The proteins are approximately 114-151 amino acids in length. The... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27343"
] | [
"MJ0207"
] | [
41
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Pseudomonadati",
"marine sediment metagenome"
] | [
34,
5,
2
] | 3 | [] | [] | 0 | true | Domain | MJ0207/MJ1342 | MJ0207/MJ1342 | MJ0207-like | 6 |
IPR060203 | 60,203 | Leucine-rich repeat-containing protein 43, C-terminal domain | LRRC43_C | Domain | 727 | false | false | This entry represents the C-terminal C2 domain of leucine-rich repeat-containing protein 43 (LRRC43). This C-terminal region contains a C2 fold structure. The specific function of this C-terminal domain remains to be determined. Leucine-rich repeat-containing protein 43 (LRRC43) is found in mammals and contains multipl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28335"
] | [
"LRRC43_C"
] | [
727
] | 1 | [] | [] | [] | 0 | [
"9ijj"
] | 1 | [
"PUB00162133"
] | [
"21677750"
] | [
"A conditional knockout resource for the genome-wide study of mouse gene function."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
727
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
7
] | 3 | true | Domain | Leucine-rich repeat-containing protein 43, C-terminal domain | Leucine-rich repeat-containing protein 43, C-terminal domain | LRRC43_C | 4 |
IPR060204 | 60,204 | Fanconi anemia group G protein, N-terminal domain | FANCG_N | Domain | 934 | false | false | This entry represents the N-terminal TPR domain of Fanconi anemia group G protein (FANCG). FANCG contains four tetratricopeptide repeat (TPR) domains that mediate protein-protein interactions. The specific function of this N-terminal TPR domain remains to be determined. Fanconi anemia (FA) is a human disorder character... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28330"
] | [
"FANCG_N"
] | [
934
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 6 | [
"PUB00089967",
"PUB00089968",
"PUB00161958",
"PUB00161959"
] | [
"18212739",
"29017571",
"9256465",
"9806548"
] | [
"FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.",
"DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.",
"The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.",
... | [
2008,
2017,
1997,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
934
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
11,
4,
2
] | 4 | true | Domain | Fanconi anemia group G protein, N-terminal domain | Fanconi anemia group G protein, N-terminal domain | FANCG_N | 1 |
IPR060205 | 60,205 | PCNA-interacting partner, N-terminal domain | PARI_N | Domain | 950 | false | false | This entry represents the N-terminal domain of PCNA-interacting partner (PARI). The specific function of this N-terminal domain remains to be determined. PARI is required to suppress inappropriate homologous recombination and plays a central role in DNA repair and maintenance of genomic stability [ ]. The protein antag... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28331"
] | [
"PARI_N"
] | [
950
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162215"
] | [
"11006283"
] | [
"The AROM gene, spliced mRNAs encoding new DNA/RNA-binding proteins are transcribed from the opposite strand of the melanin-concentrating hormone gene in mammals."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
950
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
5,
6
] | 4 | true | Domain | PCNA-interacting partner, N-terminal domain | PCNA-interacting partner, N-terminal domain | PARI_N | 9 |
IPR060206 | 60,206 | BEAN1, helical region | BEAN1_helical | Domain | 895 | false | false | This entry represents the single transmembrane helix found in BEAN1 proteins. The function of BEAN1 (brain expressed, associated with Nedd4) is not clear. Mutations in the BEAN1 gene cause spinocerebellar ataxia type 31 (SCA31), an autosomal-dominant cerebellar ataxia showing a Purkinje cell (PC)-predominant neurodegen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28336"
] | [
"BEAN1_helical"
] | [
895
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089484",
"PUB00147944"
] | [
"23607545",
"11042109"
] | [
"Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis.",
"Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase N... | [
2013,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bifidobacterium aquikefiricola",
"Vertebrata"
] | [
1,
894
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
3,
5
] | 4 | true | Domain | BEAN1, helical region | BEAN1, helical region | BEAN1_helical | 7 |
IPR060207 | 60,207 | HENMT1, C-terminal domain | HENMT1_C | Domain | 885 | false | false | This entry represents the C-terminal domain found in HENMT1 proteins from animals. HENMT1 is a small RNA 2'-O-methyltransferase that adds methyl groups to the 3'-end of piRNAs, protecting them from degradation and ensuring their stability for gametogenesis. The enzyme uses S-adenosyl-L- methionine as a cofactor and req... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28339"
] | [
"HENMT1_C"
] | [
885
] | 1 | [
"EC",
"REACTOME"
] | [
"2.1.1.386",
"R-HSA-5601884"
] | [
"EC:2.1.1.386",
"REACTOME:R-HSA-5601884"
] | 2 | [] | 0 | [
"PUB00162013",
"PUB00162014"
] | [
"18029764",
"17652135"
] | [
"2'-O-methyl modification in mouse piRNAs and its methylase.",
"The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs."
] | [
2007,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
885
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
4
] | 4 | true | Domain | HENMT1, C-terminal domain | HENMT1, C-terminal domain | HENMT1_C | 2 |
IPR060208 | 60,208 | PcoE/SilE | PcoE/SilE | Domain | 1,259 | false | false | This entry represents Silver-binding protein SilE and PcoE proteins found in Escherichia and related Enterobacteriaceae. The proteins are typically around 144 amino acids in length and are localised to the periplasm. PcoE is a copper-binding protein required for copper-inducible expression of copper resistance [ ]. The... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27346"
] | [
"PcoE"
] | [
1259
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083069",
"PUB00099025"
] | [
"8594334",
"9930866"
] | [
"Molecular genetics and transport analysis of the copper-resistance determinant (pco) from Escherichia coli plasmid pRJ1004.",
"Molecular basis for resistance to silver cations in Salmonella."
] | [
1995,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Peronospora farinosa"
] | [
1258,
1
] | 2 | [] | [] | 0 | true | Domain | PcoE/SilE | PcoE/SilE | PcoE/SilE | 2 |
IPR060209 | 60,209 | YeeR, C-terminal domain | YeeR_C | Domain | 372 | false | false | This entry represents the C-terminal domain of YeeR proteins found in Escherichia and related bacteria. The function of this C-terminal cytoplasmic domain remains to be determined. This domain is also found in other positions in uncharacterised bacterial proteins. YeeR is 510 amino acids and contains six transmembrane ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27347"
] | [
"YeeR_C"
] | [
372
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042652"
] | [
"15919996"
] | [
"Global topology analysis of the Escherichia coli inner membrane proteome."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Tetrahymena thermophila (strain SB210)"
] | [
369,
3
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YeeR, C-terminal domain | YeeR, C-terminal domain | YeeR_C | 8 |
IPR060210 | 60,210 | P-loop NTPase domain-containing protein LPA1, N-terminal domain | LPA1_N | Domain | 1,298 | false | false | This entry represents the N-terminal domain in LPA1 proteins, also known as LOW PHYTIC ACID 1 proteins. This domain is found in plants and includes multiple splice isoforms. LPA1 is required for the accumulation of phytic acid in seeds [ , ]. Phytic acid is the primary storage form of phosphorus in cereal grains and ot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28345"
] | [
"LPA1_N"
] | [
1298
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162130",
"PUB00162131"
] | [
"18566795",
"20734061"
] | [
"The rice OsLpa1 gene encodes a novel protein involved in phytic acid metabolism.",
"Genetic analysis of two OsLpa1-like genes in Arabidopsis reveals that only one is required for wild-type seed phytic acid levels."
] | [
2008,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1298
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
4,
24
] | 3 | true | Domain | P-loop NTPase domain-containing protein LPA1, N-terminal domain | P-loop NTPase domain-containing protein LPA1, N-terminal domain | LPA1_N | 8 |
IPR060211 | 60,211 | EcpR-like, N-terminal domain | EcpR-like_N | Domain | 1,128 | false | false | This entry represents the N-terminal domain of EcpR (also known as MatA), an HTH-type transcriptional regulator found in gammaproteobacteria. While the full-length protein has demonstrated transcriptional regulatory functions, the specific role of this N-terminal domain remains to be determined. This entry also include... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27348"
] | [
"EcpR_N"
] | [
1128
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042865",
"PUB00074613",
"PUB00161919",
"PUB00162497",
"PUB00162498"
] | [
"11466275",
"8626298",
"22422754",
"27869515",
"36286551"
] | [
"matB, a common fimbrillin gene of Escherichia coli, expressed in a genetically conserved, virulent clonal group.",
"Characterization of the rcsA and rcsB genes from Salmonella typhi: rcsB through tviA is involved in regulation of Vi antigen synthesis.",
"The fimbriae activator MatA switches off motility in Esc... | [
2001,
1996,
2012,
2017,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eumetazoa",
"human gut metagenome"
] | [
1123,
2,
3
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | EcpR-like, N-terminal domain | EcpR-like, N-terminal domain | EcpR-like_N | 4 |
IPR060212 | 60,212 | MJ0401-like domain | MJ0401_dom | Domain | 52 | false | false | This entry represents a domain covering the conserved region of MJ0401 and related uncharacterised proteins found in archaea and bacteria. The domain is found in diverse lineages, including Methanocaldococcaceae in archaea and various bacterial groups such as Desulfosarcinaceae, Pirellulaceae, and Chlorobiaceae. The pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27353"
] | [
"MJ0401"
] | [
52
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rhizodiscina lignyota"
] | [
26,
25,
1
] | 3 | [] | [] | 0 | true | Domain | MJ0401-like domain | MJ0401-like domain | MJ0401_dom | 1 |
IPR060213 | 60,213 | TviD, N-terminal domain | TviD_N | Domain | 264 | false | false | This entry represents the N-terminal in TviD, a protein involved in Vi polysaccharide biosynthesis in Salmonella typhi. This domain contains a SGNH hydrolase-like fold. TviD protein is required for maturation of the Vi polysaccharide, which forms part of the bacterial capsule and contributes to virulence [ , ]. The pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27354"
] | [
"TviD_N"
] | [
264
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159754",
"PUB00159856"
] | [
"8331073",
"8248629"
] | [
"Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi.",
"Identification of six open reading frames in the Salmonella enterica subsp. enterica ser. Typhi viaB locus involved in Vi antigen production."
] | [
1993,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Catovirus CTV1",
"organismal metagenomes"
] | [
241,
1,
22
] | 3 | [] | [] | 0 | true | Domain | TviD, N-terminal domain | TviD, N-terminal domain | TviD_N | 9 |
IPR060214 | 60,214 | A-kinase anchor protein 9, C-terminal domain | AKAP9_C | Domain | 1,795 | false | false | This entry represents the C-terminal domain found in AKAP9 proteins from vertebrates. This domain is present in proteins such as AKAP9 from rabbit, an A-kinase anchor protein that functions as a scaffolding protein assembling kinases and phosphatases at the centrosome and Golgi apparatus [ ]. While the full-length AKAP... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27603"
] | [
"AKAP9_C"
] | [
1795
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5576890",
"R-HSA-5576893",
"R-HSA-5620912",
"R-HSA-6802952",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5576890",
"R-MMU-5576893",
"... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5576890",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-... | 19 | [] | 0 | [
"PUB00069154",
"PUB00069156",
"PUB00069157",
"PUB00069158",
"PUB00161784"
] | [
"18093912",
"21931171",
"16753739",
"23608191",
"9148752"
] | [
"Mutation of an A-kinase-anchoring protein causes long-QT syndrome.",
"7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium.",
"BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas.",
"AKAP9 is essential for spermatogenesis an... | [
2007,
2011,
2006,
2013,
1997
] | 5 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
1795
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
19,
2,
7
] | 4 | true | Domain | A-kinase anchor protein 9, C-terminal domain | A-kinase anchor protein 9, C-terminal domain | AKAP9_C | 1 |
IPR060215 | 60,215 | MJ1155-like, helical domain | MJ1155-like_helical | Domain | 79 | false | false | This entry represents a helical domain covering the whole length of MJ1155 and related small membrane protein found in archaea and bacteria. This domain is found in diverse lineages including Archaeoglobaceae, Methanocaldococcaceae in archaea and various bacterial groups such as Bacillaceae and Oceanospirillales. The p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27356"
] | [
"MJ1155"
] | [
79
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota"
] | [
68,
11
] | 2 | [] | [] | 0 | true | Domain | MJ1155-like, helical domain | MJ1155-like, helical domain | MJ1155-like_helical | 2 |
IPR060216 | 60,216 | AKAP9/Pericentrin, N-terminal coiled coil domain | AKAP9/Pericentrin_coil_N | Domain | 3,476 | false | false | This entry represents the N-terminal coiled coil domain found in A-kinase anchor protein 9 (AKAP9, also known as AKAP 350), Pericentrin (pericentrin-B, kendrin), and similar animal proteins. AKAP9 and Pericentrin large coiled-coil proteins found in mammalian centrosomes that serve to recruit structural and regulatory c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27598"
] | [
"AKAP9_coil_N"
] | [
3476
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5576890",
"R-HSA-5576893",
"R-HSA-5620912",
"R-HSA-6802952",
"R-HSA-8854518",
"R-HSA-9613829",
"R-HSA-9615710",
"R-HSA-9646399",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5576890",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-8854518",
"REACTOME:R-HSA-9613829",
"REACTOME:R-... | 23 | [] | 0 | [
"PUB00019418",
"PUB00069153",
"PUB00161784"
] | [
"10545494",
"15047863",
"9148752"
] | [
"Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization.",
"AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.",
"Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gast... | [
1999,
2004,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Gammaproteobacteria"
] | [
3474,
2
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
36,
7,
20,
9,
11
] | 5 | true | Domain | AKAP9/Pericentrin, N-terminal coiled coil domain | AKAP9/Pericentrin, N-terminal coiled coil domain | AKAP9/Pericentrin_coil_N | 8 |
IPR060217 | 60,217 | HrpD6 | HrpD6 | Family | 291 | false | false | This entry represents HrpD6, a small regulatory protein involved in controlling the type III secretion system (T3SS) in Xanthomonas oryzae pv. oryzicola and related proteins from Pseudomonadota. HrpD6 regulates several genes of the hrp-hrc-hpa cluster, upregulating expression of hpa2, hpa1 and hpaB, and partially contr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27358"
] | [
"HrpD6"
] | [
291
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151289",
"PUB00162024",
"PUB00162025"
] | [
"21615204",
"24675748",
"16957248"
] | [
"A novel regulatory role of HrpD6 in regulating hrp-hrc-hpa genes in Xanthomonas oryzae pv. oryzicola.",
"Identification of 17 HrpX-regulated proteins including two novel type III effectors, XOC_3956 and XOC_1550, in Xanthomonas oryzae pv. oryzicola.",
"Elucidation of the hrp clusters of Xanthomonas oryzae pv. ... | [
2011,
2014,
2006
] | 3 | [] | [
"IPR048129"
] | 0 | 1 | 0 | [
"Pseudomonadota",
"plant metagenome"
] | [
288,
3
] | 2 | [] | [] | 0 | true | Family | HrpD6 | HrpD6 | HrpD6 | 7 |
IPR060218 | 60,218 | UU048 | UU048 | Family | 177 | false | false | This entry represents UU048, an uncharacterised membrane protein found in Mycoplasmatota. The protein from Ureaplasma parvum is 496 amino acids in length and contains 12 predicted transmembrane helices, making it a multi-pass membrane protein localised to the cell membrane. These proteins are found across Mycoplasmoida... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF045937",
"PF27360"
] | [
"MSC_0624_12TM",
"UU048"
] | [
171,
157
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154868"
] | [
"22685606"
] | [
"Specific evolution of F1-like ATPases in mycoplasmas."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
177
] | 1 | [] | [] | 0 | true | Family | UU048 | UU048 | UU048 | 4 |
IPR060219 | 60,219 | HrcQa, N-terminal domain | HrcQa_N | Domain | 518 | false | false | This entry represents the N-terminal domain of HrcQa proteins found in Pseudomonas and related Type III secretion proteins. While the full-length protein has demonstrated roles in type III secretion, the specific function of this N-terminal domain remains to be determined. HrcQa is a component of the type III secretion... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27361"
] | [
"HrcQa_N"
] | [
518
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00140708"
] | [
"10781092"
] | [
"The Pseudomonas syringae Hrp pathogenicity island has a tripartite mosaic structure composed of a cluster of type III secretion genes bounded by exchangeable effector and conserved effector loci that contribute to parasitic fitness and pathogenicity in plants."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Beauveria bassiana D1-5",
"Pseudomonadota"
] | [
1,
517
] | 2 | [] | [] | 0 | true | Domain | HrcQa, N-terminal domain | HrcQa, N-terminal domain | HrcQa_N | 2 |
IPR060220 | 60,220 | CRISPR-associated endoribonuclease Cas13a, C-terminal HEPN-like domain | Cas13a_endoribonuclease_C | Domain | 56 | false | false | This entry represents the C-terminal domain of CRISPR-associated endoribonuclease Cas13a. This domain is found in bacteria, particularly in Lachnospiraceae, Clostridia, and various Alphaproteobacteria. Cas13a is part of the type VI-A CRISPR-Cas system and functions as an RNA-targeting endonuclease that cleaves target s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28350"
] | [
"Cas13a_C"
] | [
56
] | 1 | [] | [] | [] | 0 | [
"5w1h",
"5w1i",
"5wlh",
"5xwp",
"5xwy",
"6vrb",
"6vrc",
"7os0",
"8ewg",
"8h4u",
"8zty"
] | 11 | [
"PUB00105601",
"PUB00105604"
] | [
"27669025",
"28475872"
] | [
"Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.",
"RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes."
] | [
2016,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenome"
] | [
55,
1
] | 2 | [] | [] | 0 | true | Domain | CRISPR-associated endoribonuclease Cas13a, C-terminal HEPN-like domain | CRISPR-associated endoribonuclease Cas13a, C-terminal HEPN-like domain | Cas13a_endoribonuclease_C | 9 |
IPR060221 | 60,221 | Cytochalasin cluster regulator ccsR-like, C-terminal domain | CcsR-like_C | Domain | 3,204 | false | false | This entry represents the C-terminal domain with a Delta-Endotoxin fold found in Cytochalasin cluster regulator ccsR from Aspergillus clavatus and similar proteins from fungi. CcsR is a transcription factor that regulates gene clusters mediating cytochalasin biosynthesis [ ]. The specific function of this domain remain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27599"
] | [
"CcsR_C"
] | [
3204
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00082314",
"PUB00082323",
"PUB00093968",
"PUB00093971",
"PUB00155601",
"PUB00161861",
"PUB00161862",
"PUB00161863",
"PUB00161864",
"PUB00161865"
] | [
"25372119",
"26662839",
"18433432",
"31099577",
"28379186",
"30598828",
"31644300",
"17175185",
"24116213",
"36452919"
] | [
"Identification of a 12-gene Fusaric Acid Biosynthetic Gene Cluster in Fusarium Species Through Comparative and Functional Genomics.",
"Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi.",
"Magnaporthe grisea avirulence gene A... | [
2015,
2016,
2008,
2019,
2017,
2018,
2019,
2007,
2013,
2022
] | 10 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3204
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Cytochalasin cluster regulator ccsR-like, C-terminal domain | Cytochalasin cluster regulator ccsR-like, C-terminal domain | CcsR-like_C | 3 |
IPR060222 | 60,222 | DCAF1, N-terminal domain | DCAF1_N | Domain | 2,160 | false | false | This entry represents the N-terminal domain of human DDB1- and CUL4-associated factor 1 (DCAF1) and similar animal proteins. This domain precedes these characterised regions and contains disordered regions. Its specific function remains to be determined [ ]. DCAF1 is a component of the CUL4-RBX1-DDB1-DCAF1 E3 ubiquitin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27670"
] | [
"DCAF1_N"
] | [
2160
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-983168",
"R-DME-983168",
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-CEL-983168",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 4 | [
"7okq",
"7v7b",
"7v7c"
] | 3 | [
"PUB00161898"
] | [
"37433110"
] | [
"The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2160
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
1,
5
] | 6 | true | Domain | DCAF1, N-terminal domain | DCAF1, N-terminal domain | DCAF1_N | 6 |
IPR060223 | 60,223 | DCAF1, helical domain | DCAF1_helical | Domain | 3,238 | false | false | This entry represents a helical domain found in human DDB1- and CUL4-associated factor 1 (DCAF1) and similar proteins from animals and plants, including DCAF-1 from Caenorhabditis elegans, a component of the CUL4-RBX1-DDB1-DCAF1 E3 ubiquitin-protein ligase complex that functions as a substrate recognition module [ ]. D... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27600"
] | [
"DCAF1_helical"
] | [
3238
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-983168",
"R-DME-983168",
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-CEL-983168",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 4 | [
"7okq",
"7v7b",
"7v7c"
] | 3 | [
"PUB00161898"
] | [
"37433110"
] | [
"The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3238
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
1,
1,
2,
1,
1,
2,
6,
33
] | 9 | true | Domain | DCAF1, helical domain | DCAF1, helical domain | DCAF1_helical | 2 |
IPR060224 | 60,224 | DCAF1, small helical domain | DCAF1_4th | Domain | 3,205 | false | false | This entry represents a small helical domain found in human DDB1- and CUL4-associated factor 1 (DCAF1) and similar proteins from animals and plants, including DCAF-1 from Caenorhabditis elegans, a component of the CUL4-RBX1-DDB1-DCAF1 E3 ubiquitin-protein ligase complex that functions as a substrate recognition module ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27601"
] | [
"DCAF1_4th"
] | [
3205
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-983168",
"R-DME-983168",
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-CEL-983168",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 4 | [
"7okq",
"7v7b",
"7v7c"
] | 3 | [
"PUB00161898"
] | [
"37433110"
] | [
"The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3205
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
1,
1,
2,
1,
1,
2,
6,
33
] | 9 | true | Domain | DCAF1, small helical domain | DCAF1, small helical domain | DCAF1_4th | 6 |
IPR060226 | 60,226 | NAD-protein ADP-ribosyltransferase ModA/ModB | ModA/B_ADP_RT | Family | 420 | false | false | This entry represents the bacteriophage T4 Mod family of ADP-ribosyltransferases, which includes ModA and ModB [ ]. These enzymes participate in the regulation of the T4 replication cycle by ADP-ribosylating defined sets of host proteins to redirect cellular metabolism from host to phage control. ModA and ModB share 25... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26816"
] | [
"Mod_ADP_RT"
] | [
420
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094440",
"PUB00094441",
"PUB00162162",
"PUB00162163",
"PUB00162164"
] | [
"16112649",
"15489438",
"10634320",
"37587340",
"7031602"
] | [
"The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: target proteins identified.",
"ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: catalytic properties and mutation analysis.",
"Overexpression, purification, and partial characterization of ADP-ribosyltransferases modA and... | [
2005,
2004,
1999,
2023,
1981
] | 5 | [] | [
"IPR043662",
"IPR043663"
] | 0 | 2 | 0 | [
"Salmonella dublin",
"Viruses"
] | [
1,
419
] | 2 | [] | [] | 0 | true | Family | NAD-protein ADP-ribosyltransferase ModA/ModB | NAD-protein ADP-ribosyltransferase ModA/ModB | ModA/B_ADP_RT | 4 |
IPR060227 | 60,227 | tRNA (adenine(9)-N1)-methyltransferase, N-terminal domain | TRM10_N | Domain | 46 | false | false | This entry represents the N-terminal domain of tRNA (adenine(9)-N1)- methyltransferase (TRM10) found in thermophilic archaea. The domain is found in Thermoproteota, particularly Sulfolobaceae including Sulfolobus, Acidianus, and Metallosphaera. The function of this N-terminal domain remains to be determined. TRM10 prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27368"
] | [
"TRM10_N"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"5a7t",
"5a7y",
"5a7z"
] | 3 | [
"PUB00075405"
] | [
"20525789"
] | [
"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
46
] | 1 | [] | [] | 0 | true | Domain | tRNA (adenine(9)-N1)-methyltransferase, N-terminal domain | tRNA (adenine(9)-N1)-methyltransferase, N-terminal domain | TRM10_N | 3 |
IPR060228 | 60,228 | tRNA (adenine(9)-N1)-methyltransferase, C-terminal domain | TRM10_C | Domain | 20 | false | false | This entry represents the C-terminal domain of tRNA (adenine(9)-N1)- methyltransferase (TRM10) found in thermophilic archaea. The domain is found in Thermoproteota, particularly Sulfolobaceae including Sulfolobus, Acidianus, and Metallosphaera. TRM10 proteins are approximately 292 amino acids and catalyse the S-adenosy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27369"
] | [
"TRM10_C"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"5a7y"
] | 1 | [
"PUB00075405"
] | [
"20525789"
] | [
"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
20
] | 1 | [] | [] | 0 | true | Domain | tRNA (adenine(9)-N1)-methyltransferase, C-terminal domain | tRNA (adenine(9)-N1)-methyltransferase, C-terminal domain | TRM10_C | 7 |
IPR060229 | 60,229 | Phage T5 A2 protein | Phage_T5_A2 | Family | 259 | false | false | The phage T5 A2 protein family is involved in the second step transfer (SST) process, which facilitates the completion of viral DNA integration into the host cell. This family includes proteins that interact with A1 proteins to form heterooligomers, playing a crucial role in the viral infection cycle [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26822"
] | [
"Phage_T5_A2"
] | [
259
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162244"
] | [
"7033565"
] | [
"Modification of RNA polymerase from Escherichia coli by pre-early gene products of bacteriophage T5."
] | [
1981
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses",
"marine metagenome"
] | [
256,
3
] | 2 | [] | [] | 0 | true | Family | Phage T5 A2 protein | Phage T5 A2 protein | Phage_T5_A2 | 3 |
IPR060230 | 60,230 | Phage spanin outer lipoprotein subunit | Phage_T4_Spanin | Family | 420 | false | false | The Spanin outer lipoprotein subunit family is involved in the disruption of the host outer membrane during viral exit [ ]. This family is a component of the spanin complex, which plays a crucial role in the final step of host cell lysis. After the inner membrane is permeabilised and host peptidoglycans are degraded by... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26831"
] | [
"Phage_T4_Spanin"
] | [
420
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105750"
] | [
"17900620"
] | [
"Rz/Rz1 lysis gene equivalents in phages of Gram-negative hosts."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Viruses",
"ecological metagenomes"
] | [
2,
415,
3
] | 3 | [] | [] | 0 | true | Family | Phage spanin outer lipoprotein subunit | Phage spanin outer lipoprotein subunit | Phage_T4_Spanin | 2 |
IPR060231 | 60,231 | Phage phiKMV holin | Phage_phiKMV_holin | Family | 38 | false | false | The Phage phiKMV holin protein family is involved in the lysis of host cells by forming nanometer-scale pores in the cytoplasmic membrane. This process leads to membrane depolarization and the release of endolysin into the periplasmic space [ ]. The endolysin then degrades the peptidoglycan layer, facilitating the rele... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF037949",
"PF26844"
] | [
"holin_5",
"Phage_phiKMV_holin"
] | [
38,
38
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162237"
] | [
"21687532"
] | [
"The lysis cassette of bacteriophage ϕKMV encodes a signal-arrest-release endolysin and a pinholin."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
38
] | 1 | [] | [] | 0 | true | Family | Phage phiKMV holin | Phage phiKMV holin | Phage_phiKMV_holin | 1 |
IPR060232 | 60,232 | NAD(+)--arginine ADP-ribosyltransferase, N-terminal | ADPRT_N | Domain | 420 | false | false | This entry represents the N-terminal region of the NAD(+)--arginine ADP-ribosyltransferase proteins mainly from Caudoviricetes. The Caudoviricetes NAD(+)--arginine ADP-ribosyltransferase family includes proteins that function as ADP-ribosyltransferases. These enzymes efficiently ADP-ribosylate the alpha subunits of hos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26846"
] | [
"Tevenvirinae_ADPRT"
] | [
420
] | 1 | [
"EC"
] | [
"2.4.2.31"
] | [
"EC:2.4.2.31"
] | 1 | [] | 0 | [
"PUB00094440",
"PUB00162317",
"PUB00162318",
"PUB00162319",
"PUB00162320"
] | [
"16112649",
"9193638",
"173540",
"11021939",
"26395283"
] | [
"The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: target proteins identified.",
"ADP-ribosylation and early transcription regulation by bacteriophage T4.",
"ADP-ribosylation of DNA-dependent RNA polymerase of Escherichia coli by an NAD+: protein ADP-ribosyltransferase from bacteriophage T4.",
... | [
2005,
1997,
1975,
2000,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
420
] | 1 | [] | [] | 0 | true | Domain | NAD(+)--arginine ADP-ribosyltransferase, N-terminal | NAD(+)--arginine ADP-ribosyltransferase, N-terminal | ADPRT_N | 5 |
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