interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060233 | 60,233 | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, N-terminal domain | TRM10_Arch_N | Domain | 59 | false | false | This entry represents the N-terminal domain of archaeal tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase (TRM10) found in hyperthermophilic archaea. This domain is found in Thermococcaceae, particularly Thermococcus, and Archaeoglobaceae including Archaeoglobus. The function of this N-terminal domain remains to be de... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27379"
] | [
"TRM10_Arch_N"
] | [
59
] | 1 | [] | [] | [] | 0 | [
"6ems"
] | 1 | [
"PUB00075405"
] | [
"20525789"
] | [
"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
59
] | 1 | [] | [] | 0 | true | Domain | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, N-terminal domain | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, N-terminal domain | TRM10_Arch_N | 3 |
IPR060234 | 60,234 | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, C-terminal domain | TRM10_Arch_C | Domain | 59 | false | false | This entry represents the C-terminal domain of archaeal tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase (TRM10) found in hyperthermophilic archaea. The domain is found in Thermococcaceae, particularly Thermococcus, and Archaeoglobaceae including Archaeoglobus. TRM10 proteins are approximately 370 amino acids and cat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27381"
] | [
"TRM10_Arch_C"
] | [
59
] | 1 | [] | [] | [] | 0 | [
"6ems"
] | 1 | [
"PUB00075405"
] | [
"20525789"
] | [
"New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
59
] | 1 | [] | [] | 0 | true | Domain | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, C-terminal domain | tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase, C-terminal domain | TRM10_Arch_C | 4 |
IPR060235 | 60,235 | TP_0929, third domain | TP_0929_3rd | Domain | 68 | false | false | This entry represents the third domain of TP_0929 proteins. The domain is found predominantly in Spirochaetota, with representatives in Treponema and related spirochetes. The function of this domain remains to be determined. This domain is also found in putative PpiC domain-containing proteins from bacteria and is usua... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27392"
] | [
"TP_0929_3rd"
] | [
68
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
66,
2
] | 2 | [] | [] | 0 | true | Domain | TP_0929, third domain | TP_0929, third domain | TP_0929_3rd | 5 |
IPR060236 | 60,236 | Aq_aa27, P-loop NTPase domain | P-loop_Aq_aa27 | Domain | 440 | false | false | This entry represents a domain found towards the C-terminal region in Uncharacterized protein aq_aa27 from Aquifex aeolicus. This domain contains a P-loop nucleoside triphosphate hydrolase fold ( ) and is found predominantly in Bacillota, with representatives in Bacilli and Clostridia classes, and it is also found in H... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27394"
] | [
"Aq_aa27"
] | [
440
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteria",
"ecological metagenomes"
] | [
345,
91,
4
] | 3 | [] | [] | 0 | true | Domain | Aq_aa27, P-loop NTPase domain | Aq_aa27, P-loop NTPase domain | P-loop_Aq_aa27 | 1 |
IPR060237 | 60,237 | Phage P1 replication protein RepL | Phage_P1_RepL | Family | 163 | false | false | This entry represents replication protein RepL found in bacteriophages. The prototype is from Escherichia phage P1, a 281 amino acid protein with a molecular weight of 30.9 kDa. RepL is essential for L-replicon function and is necessary for initiation of DNA replication from the L-replicon at the oriL origin of replica... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26868"
] | [
"Phage_P1_RepL"
] | [
163
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Enterobacterales",
"Punavirus",
"feces metagenome"
] | [
152,
10,
1
] | 3 | [] | [] | 0 | true | Family | Phage P1 replication protein RepL | Phage P1 replication protein RepL | Phage_P1_RepL | 1 |
IPR060239 | 60,239 | Mycobacterium phage L5 gene 81 protein | Phage_L5_Gp81 | Family | 37 | false | false | This entry represents the gene 81 protein family found in L5-like mycobacteriophages. Gene 81 protein is an uncharacterised protein of 111 amino acids (12.4 kDa) found in Mycobacterium phage L5. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26898"
] | [
"Phage_L5_Gp81"
] | [
37
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes"
] | [
3,
34
] | 2 | [] | [] | 0 | true | Family | Mycobacterium phage L5 gene 81 protein | Mycobacterium phage L5 gene 81 protein | Phage_L5_Gp81 | 9 |
IPR060240 | 60,240 | Bacteriophage T4 protein Y05C | Phage_T4_Y05C | Family | 163 | false | false | This entry represents the Y05C protein family found in T4-like bacteriophages. Y05C is an uncharacterised protein of 133 amino acids (15.3 kDa) found in the nrdC-mobD intergenic region of bacteriophage T4. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26908"
] | [
"Phage_T4_Y05C"
] | [
163
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dyella japonica DSM 16301",
"Viruses"
] | [
1,
162
] | 2 | [] | [] | 0 | true | Family | Bacteriophage T4 protein Y05C | Bacteriophage T4 protein Y05C | Phage_T4_Y05C | 2 |
IPR060241 | 60,241 | Intimin, immunoglobulin-like domain | Ig_Eae | Domain | 1,673 | false | false | This immunoglobulin-like (Ig-like) domain is found in a group of Intimin proteins from proteobacteria, including Eae from Escherichia coli. Eae is an adhesin, which mediates attachment to the human intestine epithelial cells. It functions as an inverse autotransporter [ , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26918"
] | [
"Ig_Eae"
] | [
1673
] | 1 | [] | [] | [] | 0 | [
"1e5u",
"1f00",
"1f02",
"2zqk",
"2zwk",
"3ncw",
"3ncx",
"9cuy",
"9mjn"
] | 9 | [
"PUB00006621",
"PUB00056155",
"PUB00162077",
"PUB00162078"
] | [
"10835344",
"2172966",
"25353290",
"33277518"
] | [
"Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli.",
"A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.",
"The Intimin periplasmic domain mediat... | [
2000,
1990,
2015,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Stenosarchaea group",
"Stylophora pistillata",
"metagenomes"
] | [
1645,
3,
5,
1,
19
] | 5 | [] | [] | 0 | true | Domain | Intimin, immunoglobulin-like domain | Intimin, immunoglobulin-like domain | Ig_Eae | 5 |
IPR060242 | 60,242 | ABC transporter domain-containing protein-like, C-terminal domain | ABC-like_C | Domain | 2,136 | false | false | This entry represents the C-terminal domain found in putative Multidrug ABC transporter ATP-binding proteins from bacteria. This domain contains four β-sheets connected to an α-helix. This domain is usually found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26919"
] | [
"ABC-like_C"
] | [
2136
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2126,
10
] | 2 | [] | [] | 0 | true | Domain | ABC transporter domain-containing protein-like, C-terminal domain | ABC transporter domain-containing protein-like, C-terminal domain | ABC-like_C | 7 |
IPR060243 | 60,243 | KilR, SH3-type barrel domain | SH3_KilR | Domain | 546 | false | false | This entry represents a domain of approximately 73 amino acids that adopts an SH3-type barrel fold structure. The domain is found in KilR proteins. The proteins are found in bacteria and viruses, including prophage sequences. The domain is responsible for the cell division inhibitory activity. KilR causes inhibition of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27398"
] | [
"KilR"
] | [
546
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161723",
"PUB00162114"
] | [
"8752325",
"7508908"
] | [
"Identification of a new inhibitor of essential division gene ftsZ as the kil gene of defective prophage Rac.",
"Division inhibition gene dicF of Escherichia coli reveals a widespread group of prophage sequences in bacterial genomes."
] | [
1996,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes"
] | [
526,
20
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | KilR, SH3-type barrel domain | KilR, SH3-type barrel domain | SH3_KilR | 3 |
IPR060244 | 60,244 | Bacteriophage T4 protein 52.2 | Phage_T4_Ac | Family | 105 | false | false | This entry represents Uncharacterized protein 52.2 found in T4-like bacteriophages. This protein is an uncharacterised membrane protein of 51 amino acids (5.5 kDa) that localises to the host membrane. The protein contains two predicted transmembrane helices (residues 6-26 and 28-48). Mutations in this gene confer resis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26944"
] | [
"Phage_T4_Ac"
] | [
105
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162239"
] | [
"9560385"
] | [
"The spectrum of acridine resistant mutants of bacteriophage T4 reveals cryptic effects of the tsL141 DNA polymerase allele on spontaneous mutagenesis."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
105
] | 1 | [] | [] | 0 | true | Family | Bacteriophage T4 protein 52.2 | Bacteriophage T4 protein 52.2 | Phage_T4_Ac | 5 |
IPR060245 | 60,245 | Ecto-NOX disulfide-thiol exchanger 1/2, C-terminal helix-turn-helix domain | HTH_ENOX1 | Domain | 3,120 | false | false | This helix-turn-helix (HTH) domain is found at the C-terminal end of human Ecto-NOX disulfide-thiol exchanger 1 (ENOX1). ENOX1/2 probably act as terminal oxidases of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface, playing a role in control of the ultradian cellular b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27602"
] | [
"HTH_ENOX1"
] | [
3120
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00082751",
"PUB00129213",
"PUB00129215",
"PUB00129220",
"PUB00159022"
] | [
"19055324",
"11360993",
"17027975",
"9932650",
"12356293"
] | [
"Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase.",
"A drug-unresponsive and protease-resistant CNOX protein from human sera.",
"A role for copper in biological time-keeping.",
"The sulfonylurea-inhibited NADH ox... | [
2008,
2001,
2006,
1998,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3120
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
3,
7,
7,
14
] | 5 | true | Domain | Ecto-NOX disulfide-thiol exchanger 1/2, C-terminal helix-turn-helix domain | Ecto-NOX disulfide-thiol exchanger 1/2, C-terminal helix-turn-helix domain | HTH_ENOX1 | 1 |
IPR060246 | 60,246 | MJECL01, C-terminal domain | MJECL01_C | Domain | 47 | false | false | This entry represents the C-terminal domain in MJECL01 uncharacterised proteins found exclusively in thermoacidophilic archaea. The domain is found in Thermoproteota, particularly Sulfolobaceae including Saccharolobus, Acidianus and Metallosphaera. The full-length proteins are approximately 249 amino acids and contain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27406"
] | [
"MJECL01_C"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
47
] | 1 | [] | [] | 0 | true | Domain | MJECL01, C-terminal domain | MJECL01, C-terminal domain | MJECL01_C | 6 |
IPR060247 | 60,247 | PB2B2.08-like | PB2B2.08-like | Family | 1,390 | false | false | This entry represents a group of uncharacterised proteins from yeast, including PB2B2.08 from Schizosaccharomyces pombe. It is predicted to show an α-β configuration. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF27604",
"PTHR36986"
] | [
"PB2B2_08",
""
] | [
1390,
1363
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
1382
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | PB2B2.08-like | PB2B2.08-like | PB2B2.08-like | 5 |
IPR060248 | 60,248 | AF0774 | AF0774 | Family | 23 | false | false | This entry represents AF0774-like proteins found in archaea. These are small proteins of approximately 110 amino acids found in the Archaeoglobi class, including Archaeoglobus, Geoglobus, and Ferroglobus species, as well as some methanogens. The function of this protein remains to be determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27410"
] | [
"AF0774"
] | [
23
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
23
] | 1 | [] | [] | 0 | true | Family | AF0774 | AF0774 | AF0774 | 6 |
IPR060249 | 60,249 | S-layer protein A, third immunoglobulin-like domain | Ig-like_SlaA_3rd | Domain | 43 | false | false | This entry represents the third immunoglobulin-like domain of S-layer protein A (SlaA) found in Sulfolobales archaea. The specific function of this immunoglobulin-like domain within the S-layer structure remains to be determined. SlaA is a large glycosylated protein that forms part of the highly ordered outer cell wall... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27413"
] | [
"SlaA_5th"
] | [
43
] | 1 | [] | [] | [] | 0 | [
"7zcx",
"8an2",
"8an3",
"8qox",
"8qp0"
] | 5 | [
"PUB00106156",
"PUB00106157"
] | [
"16391651",
"20936123"
] | [
"Molecular organization of selected prokaryotic S-layer proteins.",
"The S-layer glycoprotein of the crenarchaeote Sulfolobus acidocaldarius is glycosylated at multiple sites with chitobiose-linked N-glycans."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
43
] | 1 | [] | [] | 0 | true | Domain | S-layer protein A, third immunoglobulin-like domain | S-layer protein A, third immunoglobulin-like domain | Ig-like_SlaA_3rd | 4 |
IPR060250 | 60,250 | ODF2-like, C-terminal coiled coil domain | ODF2-like_C | Domain | 3,498 | false | false | This entry represents the C-terminal coiled coil domain of human outer dense fiber protein 2 (ODF2), its homologue Protein BCAP, and similar proteins mainly found in animals. The function of this domain remains to be determined. ODF2 is a major component of the outer dense fibres in mammalian sperm tails and plays a cr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27605"
] | [
"ODF2_C"
] | [
3498
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [] | 0 | [
"PUB00060017",
"PUB00060018",
"PUB00162210",
"PUB00162499"
] | [
"15852003",
"9740324",
"15340007",
"16966375"
] | [
"Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia.",
"Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail.",
"Outer dense fibre protein 2 (ODF2) is a self-intera... | [
2005,
1998,
2004,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota"
] | [
11,
44,
3443
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
17,
10,
21
] | 4 | true | Domain | ODF2-like, C-terminal coiled coil domain | ODF2-like, C-terminal coiled coil domain | ODF2-like_C | 4 |
IPR060251 | 60,251 | Cytidine deaminase-like, bacterial | CDL_bac | Domain | 2,512 | false | false | This entry represents a cytidine deaminase-like (CDL) domain found in bacterial proteins. CDL enzymes catalyse the deamination of cytidine and 2'-deoxycitidine with similar efficiencies [ ]. The canonical CD domain consists of an α-β(2) -(α-β)2 that folds into three layers. This domain displays a similar fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26947"
] | [
"CDL"
] | [
2512
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00032259"
] | [
"15180998"
] | [
"Crystal structure of Bacillus subtilis guanine deaminase: the first domain-swapped structure in the cytidine deaminase superfamily."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Aduncisulcus paluster",
"Bacteria",
"Halogranum rubrum",
"metagenomes"
] | [
1,
2446,
1,
64
] | 4 | [] | [] | 0 | true | Domain | Cytidine deaminase-like, bacterial | Cytidine deaminase-like, bacterial | CDL_bac | 1 |
IPR060252 | 60,252 | Cullin-associated NEDD8-dissociated protein 1 N-terminal part, TPR domain | CandA_N_TPR | Domain | 1,024 | false | false | This entry represents the TPR (tetratricopeptide repeat) domain found in CandA-N (Cullin-associated NEDD8-dissociated protein 1 N-terminal part). The specific function of this TPR domain remains to be determined. CandA-N is an assembly factor of SCF E3 ubiquitin ligase complexes that promotes exchange of F-box subunits... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28359"
] | [
"CandA_N"
] | [
1024
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161843"
] | [
"21119001"
] | [
"Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1024
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Cullin-associated NEDD8-dissociated protein 1 N-terminal part, TPR domain | Cullin-associated NEDD8-dissociated protein 1 N-terminal part, TPR domain | CandA_N_TPR | 1 |
IPR060253 | 60,253 | TP_0324, N-terminal domain | TP_0324_N | Domain | 103 | false | false | This entry represents the N-terminal region of TP_0324 proteins. This domain contains a structure with multiple repeating modules comprising five β-sheets followed by a loop, and forms a long hydrophobic groove. The domain is found predominantly in Spirochaetota, with representatives in Treponema and Spirochaeta genera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27414"
] | [
"TP_0324_N"
] | [
103
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
102,
1
] | 2 | [] | [] | 0 | true | Domain | TP_0324, N-terminal domain | TP_0324, N-terminal domain | TP_0324_N | 8 |
IPR060254 | 60,254 | BigA, fourth pectate lyase-like domain | BigA_4th | Domain | 2,847 | false | false | This entry represents the fourth domain of BigA autotransporter proteins found in Salmonella and related Enterobacteriaceae. BigA is a large surface-exposed virulence protein of approximately 1953 amino acids that contains an autotransporter domain and multiple repeats. This fourth domain adopts a pectate lyase-like fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27415"
] | [
"BigA_4th"
] | [
2847
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008435"
] | [
"9778731"
] | [
"The great escape: structure and function of the autotransporter proteins."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
2844,
3
] | 2 | [] | [] | 0 | true | Domain | BigA, fourth pectate lyase-like domain | BigA, fourth pectate lyase-like domain | BigA_4th | 9 |
IPR060255 | 60,255 | BigA, third pectate lyase-like domain | BigA_3rd | Domain | 3,772 | false | false | This entry represents the third domain of BigA proteins. The domain adopts a pectate lyase-like fold structure. BigA proteins are putative surface-exposed virulence proteins found in bacteria, predominantly in Pseudomonadota including Gammaproteobacteria and Betaproteobacteria. The proteins contain an autotransporter d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27417"
] | [
"BigA_3rd"
] | [
3772
] | 1 | [] | [] | [] | 0 | [
"9qe7"
] | 1 | [
"PUB00008435"
] | [
"9778731"
] | [
"The great escape: structure and function of the autotransporter proteins."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Muraenolepis orangiensis"
] | [
3771,
1
] | 2 | [] | [] | 0 | true | Domain | BigA, third pectate lyase-like domain | BigA, third pectate lyase-like domain | BigA_3rd | 3 |
IPR060257 | 60,257 | TP_0855, helical bundle domain | TP_0855_helical | Domain | 56 | false | false | This entry represents a helical bundle domain found in TP_0855 proteins from Treponema and related spirochaetes. This domain forms a small helical bundle structure. TP_0855 is a large protein of approximately 1127 amino acids that is processed from a precursor containing an N-terminal signal peptide and contains a coil... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27421"
] | [
"TP_0855_helical"
] | [
56
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
55,
1
] | 2 | [] | [] | 0 | true | Domain | TP_0855, helical bundle domain | TP_0855, helical bundle domain | TP_0855_helical | 4 |
IPR060258 | 60,258 | TP_0855, C-terminal | TP_0855_C | Domain | 51 | false | false | This entry represents the C-terminal domain of TP_0855 proteins found primarily in Treponema and related spirochaetes. TP_0855 is a large protein of approximately 1127 amino acids that is processed from a precursor containing an N-terminal signal peptide. The function of this domain remains to be determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27427"
] | [
"TP_0855_C"
] | [
51
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
51
] | 1 | [] | [] | 0 | true | Domain | TP_0855, C-terminal | TP_0855, C-terminal | TP_0855_C | 2 |
IPR060259 | 60,259 | Thioredoxin-like domain, nematodes | Thioredoxin-like_nematodes | Domain | 151 | false | false | This entry represents a Thioredoxin-like domain at the C-terminal in uncharacterised Thioredoxin-domain containing proteins mostly found in nematodes. This domain belongs to the Thioredoxin-like superfamily . Members of this superfamily are small redox-active proteins that mediate thiol-disulfide exchange through a con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26957"
] | [
"Thioredoxin-like_C"
] | [
151
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00115488"
] | [
"15558583"
] | [
"Structural classification of thioredoxin-like fold proteins."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
151
] | 1 | [] | [] | 0 | true | Domain | Thioredoxin-like domain, nematodes | Thioredoxin-like domain, nematodes | Thioredoxin-like_nematodes | 4 |
IPR060260 | 60,260 | LB_356 | LB_356 | Domain | 427 | false | false | This entry represents a domain covering the full length of LB_356 proteins found primarily in Leptospira and related bacteria. LB_356 is a protein of approximately 530 amino acids. The protein is also found in some Flavobacteriaceae and other bacterial groups. The function of this protein remains to be determined. It c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27429"
] | [
"LB_356"
] | [
427
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanocorpusculum",
"metagenomes"
] | [
415,
2,
10
] | 3 | [] | [] | 0 | true | Domain | LB_356 | LB_356 | LB_356 | 4 |
IPR060261 | 60,261 | YOL029C, N-terminal domain | YOL029C_N | Domain | 626 | false | false | This entry represents the N-terminal domain of the uncharacterised protein YOL029C from Saccharomyces cerevisiae. YOL029C interacts with the molecular chaperones HSP82 and HSC82 [ ]. The function of this protein and its N-terminal domain remains to be determined. This domain is found next to a disordered region. It is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28364"
] | [
"YOL029C_N"
] | [
626
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162424"
] | [
"15633294"
] | [
"Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
626
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | YOL029C, N-terminal domain | YOL029C, N-terminal domain | YOL029C_N | 6 |
IPR060262 | 60,262 | UvrABC system protein B, third helical domain | UvrB_3rd | Domain | 27,100 | false | false | This entry represents the third helical domain of UvrB proteins, which are essential components of the UvrABC nucleotide excision repair system. This small helical domain contributes to the overall architecture of the UvrB protein. The domain is found across diverse bacterial taxa and in archaea. In Eubacteria and some... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27431"
] | [
"UvrB_3rd"
] | [
27100
] | 1 | [] | [] | [] | 0 | [
"1c4o",
"1d2m",
"1d9x",
"1d9z",
"1t5l",
"2d7d",
"2fdc",
"2nmv",
"3uwx",
"3v4r",
"6o8e",
"6o8f",
"6o8g",
"6o8h",
"7egt",
"9ga3",
"9ga4"
] | 17 | [
"PUB00057848"
] | [
"12145219"
] | [
"The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
611,
25754,
169,
2,
564
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | UvrABC system protein B, third helical domain | UvrABC system protein B, third helical domain | UvrB_3rd | 4 |
IPR060263 | 60,263 | Thioredoxin-like domain, plants | Thioredoxin-like_N_plants | Domain | 679 | false | false | This entry represents a Thioredoxin-like domain at the N-terminal in putative Thioredoxin-domain containing proteins and other uncharacterised proteins mostly found in plants. This domain belongs to the Thioredoxin-like superfamily . Members of this superfamily are small redox-active proteins that mediate thiol-disulfi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26959"
] | [
"Thioredoxin-like_N"
] | [
679
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00115488"
] | [
"15558583"
] | [
"Structural classification of thioredoxin-like fold proteins."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
679
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
2,
2
] | 3 | true | Domain | Thioredoxin-like domain, plants | Thioredoxin-like domain, plants | Thioredoxin-like_N_plants | 7 |
IPR060264 | 60,264 | GPR137, N-terminal domain | GPR137_N | Domain | 3,006 | false | false | This entry represents the N-terminal lumenal domain of GPR137 animal proteins. This domain is located in the lysosomal lumen and contains N-linked glycosylation sites that are characteristic of proteins with proper membrane topology. The N-terminal region precedes the first transmembrane helix and establishes the lumen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27607"
] | [
"GPR137_N"
] | [
3006
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00145336"
] | [
"31036939"
] | [
"The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3006
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
24,
22,
12
] | 4 | true | Domain | GPR137, N-terminal domain | GPR137, N-terminal domain | GPR137_N | 5 |
IPR060265 | 60,265 | MimR-like, N-terminal domain | MimR-like_N | Domain | 13,948 | false | false | This domain is found at the N-terminal of Propane 2-monooxygenase operon transcriptional activator MimR from Mycolicibacterium smegmatis and related proteins, including Acetoin dehydrogenase operon transcriptional activator AcoR and Signal-transduction and transcriptional-control protein. This domain is predicted to sh... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26965"
] | [
"MimR_N"
] | [
13948
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162158",
"PUB00162159",
"PUB00162160"
] | [
"21856847",
"11274109",
"16944132"
] | [
"Identification of the regulator gene responsible for the acetone-responsive expression of the binuclear iron monooxygenase gene cluster in mycobacteria.",
"Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis.",
"An acetoin-regulated expression system of Bacillus subtilis."... | [
2011,
2001,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
13885,
5,
58
] | 3 | [] | [] | 0 | true | Domain | MimR-like, N-terminal domain | MimR-like, N-terminal domain | MimR-like_N | 2 |
IPR060266 | 60,266 | VPS35 endosomal protein-sorting factor-like, N-terminal domain | VPS35L_N | Domain | 3,336 | false | false | This entry represents VPS35 endosomal protein-sorting factor-like (VPS35L) proteins from animals and plants. In zebrafish, VPS35L is a component of the retriever complex essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. The full-length VPS35L protein drives the retrieval a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27614"
] | [
"VPS35L_N"
] | [
3336
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6798695",
"R-DME-6798695",
"R-DRE-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 6 | [
"8p0v",
"8p0x",
"8sym",
"8syn",
"8syo",
"9au7"
] | 6 | [
"PUB00077066",
"PUB00092769",
"PUB00162386"
] | [
"25355947",
"28892079",
"31712251"
] | [
"COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.",
"Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.",
"Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever ... | [
2015,
2017,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3336
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
1,
3,
2,
9,
6,
14
] | 7 | true | Domain | VPS35 endosomal protein-sorting factor-like, N-terminal domain | VPS35 endosomal protein-sorting factor-like, N-terminal domain | VPS35L_N | 4 |
IPR060267 | 60,267 | ELMO, N-terminal ubiquitin-like domain | ELMO_N | Domain | 4,346 | false | false | This entry represents the N-terminal domain found in ELMO proteins. It has an ubiquitin-like fold [ ]. The Engulfment and Cell Motility (ELMO) protein family is involved in cytoskeletal rearrangements essential for the phagocytosis of apoptotic cells and cell motility [ , , ]. Members of this family function in associa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26964"
] | [
"ELMO_N"
] | [
4346
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-164944",
"R-HSA-2029482",
"R-HSA-4420097",
"R-HSA-8849471",
"R-HSA-9013408",
"R-HSA-9664422",
"R-MMU-2029482",
"R-MMU-4420097",
"R-MMU-8849471",
"R-MMU-9013408"
] | [
"REACTOME:R-HSA-164944",
"REACTOME:R-HSA-2029482",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-8849471",
"REACTOME:R-HSA-9013408",
"REACTOME:R-HSA-9664422",
"REACTOME:R-MMU-2029482",
"REACTOME:R-MMU-4420097",
"REACTOME:R-MMU-8849471",
"REACTOME:R-MMU-9013408"
] | 10 | [
"6idx",
"6ie1",
"6jpp",
"6tgb",
"6tgc",
"6uka",
"7dpa",
"7y4a",
"8jhk",
"8xm7",
"8zj2",
"8zji",
"8zjj",
"8zjk",
"8zjl",
"8zjm"
] | 16 | [
"PUB00019508",
"PUB00033454",
"PUB00061822",
"PUB00161932",
"PUB00161933",
"PUB00161934"
] | [
"11595183",
"12134158",
"20679435",
"11703939",
"27476657",
"21035343"
] | [
"CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.",
"Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.",
"Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.",
"The C. elegans PH domain protein ... | [
2001,
2002,
2010,
2001,
2016,
2010
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4346
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
2,
13,
10,
13
] | 5 | true | Domain | ELMO, N-terminal ubiquitin-like domain | ELMO, N-terminal ubiquitin-like domain | ELMO_N | 9 |
IPR060268 | 60,268 | TatB, coiled-coil domain, Pasteurellaceae | TatB_CC_Pasteurellaceae | Domain | 173 | false | false | This entry represents a coiled-coil domain in TatB proteins found in Pasteurellaceae and related bacteria. This domain adopts a coiled-coil structure and is part of the twin-arginine translocation (Tat) system. The function of this specific domain remains to be determined. Translocation of proteins across the two membr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27442"
] | [
"TatB_C"
] | [
173
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007662",
"PUB00007663"
] | [
"9649434",
"10652088"
] | [
"Overlapping functions of components of a bacterial Sec-independent protein export pathway.",
"The Tat protein export pathway."
] | [
1998,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Pasteurellaceae"
] | [
173
] | 1 | [] | [] | 0 | true | Domain | TatB, coiled-coil domain, Pasteurellaceae | TatB, coiled-coil domain, Pasteurellaceae | TatB_CC_Pasteurellaceae | 6 |
IPR060269 | 60,269 | Adaptation to cold protein A | AtcA | Family | 149 | false | false | This entry represents adaptation to cold protein A (AtcA) found primarily in Shewanella and related marine bacteria. AtcA is a protein of approximately 179 amino acids that is part of the atcJABC operon involved in cold adaptation [ ]. The protein contains a C-terminal disordered region (residues 133-179) with acidic r... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047888",
"PF27445"
] | [
"ColdAdpAtcA",
"AtcA"
] | [
129,
149
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161810"
] | [
"31482142"
] | [
"Cold adaptation in the environmental bacterium <i>Shewanella oneidensis</i> is controlled by a J-domain co-chaperone protein network."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
149
] | 1 | [] | [] | 0 | true | Family | Adaptation to cold protein A | Adaptation to cold protein A | AtcA | 3 |
IPR060270 | 60,270 | Lipoteichoic acid synthase, N-terminal domain | LtaS_N | Domain | 7,045 | false | false | This entry represents the N-terminal transmembrane domain of lipoteichoic acid synthase-like proteins. Lipoteichoic acid synthase catalyses the polymerisation of lipoteichoic acid polyglycerol phosphate and is required for staphylococcal growth and cell division. The protein contains an N-terminal transmembrane domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27449"
] | [
"LtaS_N"
] | [
7045
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.8.-",
"PWY-6350",
"PWY-6580",
"PWY-6804",
"PWY-7815",
"PWY-7816",
"PWY-7817",
"PWY-7818",
"PWY-7819",
"PWY-7820",
"PWY-7981",
"PWY-8248"
] | [
"EC:2.7.8.-",
"METACYC:PWY-6350",
"METACYC:PWY-6580",
"METACYC:PWY-6804",
"METACYC:PWY-7815",
"METACYC:PWY-7816",
"METACYC:PWY-7817",
"METACYC:PWY-7818",
"METACYC:PWY-7819",
"METACYC:PWY-7820",
"METACYC:PWY-7981",
"METACYC:PWY-8248"
] | 12 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Streptococcus phage 20617",
"metagenomes"
] | [
7033,
6,
1,
5
] | 4 | [
"Arabidopsis thaliana",
"Rattus norvegicus"
] | [
1,
1
] | 2 | true | Domain | Lipoteichoic acid synthase, N-terminal domain | Lipoteichoic acid synthase, N-terminal domain | LtaS_N | 2 |
IPR060271 | 60,271 | GTF2H2, zinc ribbon domain | Zn_ribbon_GTF2H2 | Domain | 462 | false | false | This domain is found in General transcription factor IIH subunit 2 (GTF2H2) from Arabidopsis thaliana and related plant proteins. The domain represented by this entry contains four invariant cysteine residues and is predicted to adopt a fold typical for zinc β-ribbon domains. GTF2H2 is a component of the general transc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27618"
] | [
"Zn_ribbon_GTF2H2"
] | [
462
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162442"
] | [
"16623910"
] | [
"Arabidopsis homologue of human transcription factor IIH/nucleotide excision repair factor p44 can function in transcription and DNA repair and interacts with AtXPD."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
14,
448
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio"
] | [
6,
1
] | 2 | true | Domain | GTF2H2, zinc ribbon domain | GTF2H2, zinc ribbon domain | Zn_ribbon_GTF2H2 | 6 |
IPR060272 | 60,272 | DnaJ homolog subfamily C member 16, thioredoxin-like domain 3 | DJC16_3rd | Domain | 2,163 | false | false | This entry represents the third Thioredoxin-like domain in DnaJ homolog subfamily C member 16 (DJC16) and similar proteins mostly from animals. DJC16 is involved in the regulation of autophagosome size during their formation. Autophagosomes are essential components in the cellular process of autophagy, which is respons... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26968"
] | [
"Thioredoxin-like_DJC16_3rd"
] | [
2163
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161903"
] | [
"32492081"
] | [
"ERdj8 governs the size of autophagosomes during the formation process."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2163
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
2,
5,
1,
3
] | 6 | true | Domain | DnaJ homolog subfamily C member 16, thioredoxin-like domain 3 | DnaJ homolog subfamily C member 16, thioredoxin-like domain 3 | DJC16_3rd | 3 |
IPR060273 | 60,273 | Gamma carbonic anhydrase 1, C-terminal domain | GAMMACA1_C | Domain | 1,369 | false | false | This entry represents the C-terminal domain of gamma-class carbonic anhydrases (GAMMACA1) found in plants. The specific function of this C-terminal domain remains to be determined. GAMMACA1 functions as homotrimers and is involved in the catabolism of bicarbonate but does not mediate the reversible hydration of carbon ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28366"
] | [
"GAMMACA1_C"
] | [
1369
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"4.2.1.-",
"PWY-2229",
"PWY-2467",
"PWY-5061",
"PWY-5367",
"PWY-5408",
"PWY-5409",
"PWY-5410",
"PWY-5644",
"PWY-5780",
"PWY-5793",
"PWY-5979",
"PWY-6322",
"PWY-6602",
"PWY-6627",
"PWY-6672",
"PWY-6679",
"PWY-6721",
"PWY-6749",
"PWY-6944",
"PWY-6945",
"PWY-6946",
"PWY-6948... | [
"EC:4.2.1.-",
"METACYC:PWY-2229",
"METACYC:PWY-2467",
"METACYC:PWY-5061",
"METACYC:PWY-5367",
"METACYC:PWY-5408",
"METACYC:PWY-5409",
"METACYC:PWY-5410",
"METACYC:PWY-5644",
"METACYC:PWY-5780",
"METACYC:PWY-5793",
"METACYC:PWY-5979",
"METACYC:PWY-6322",
"METACYC:PWY-6602",
"METACYC:PWY-6... | 53 | [
"6x89",
"7a23",
"7a24",
"7aqq",
"7ar7",
"7ar8",
"7arb",
"8bef",
"8bpx",
"8bq5",
"8bq6",
"8e73"
] | 12 | [
"PUB00102642",
"PUB00161970",
"PUB00161971",
"PUB00161972"
] | [
"19808034",
"15604675",
"16407270",
"15935378"
] | [
"Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon.",
"Gamma carbonic anhydrases in plant mitochondria.",
"Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants.",
"Disruption of a nuclear gene encoding a mitochond... | [
2009,
2004,
2006,
2005
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1369
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
7,
13
] | 3 | true | Domain | Gamma carbonic anhydrase 1, C-terminal domain | Gamma carbonic anhydrase 1, C-terminal domain | GAMMACA1_C | 3 |
IPR060274 | 60,274 | DnaJ homolog subfamily C member 16, thioredoxin-like domain 2 | DJC16_2nd | Domain | 2,302 | false | false | This entry represents the second Thioredoxin-like domain in DnaJ homolog subfamily C member 16 (DJC16) and similar proteins mostly from animals. DJC16 is involved in the regulation of autophagosome size during their formation. Autophagosomes are essential components in the cellular process of autophagy, which is respon... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26973"
] | [
"Thioredoxin-like_DJC16_2nd"
] | [
2302
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161903"
] | [
"32492081"
] | [
"ERdj8 governs the size of autophagosomes during the formation process."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2302
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
2,
5,
1,
3
] | 6 | true | Domain | DnaJ homolog subfamily C member 16, thioredoxin-like domain 2 | DnaJ homolog subfamily C member 16, thioredoxin-like domain 2 | DJC16_2nd | 1 |
IPR060275 | 60,275 | DnaJ homolog subfamily C member 16, C-terminal domain | DJC16_C | Domain | 2,212 | false | false | This entry represents the C-terminal domain in DnaJ homolog subfamily C member 16 (DJC16) and similar proteins from animals. DJC16 is involved in the regulation of autophagosome size during their formation. Autophagosomes are essential components in the cellular process of autophagy, which is responsible for degrading ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26976"
] | [
"DJC16_C"
] | [
2212
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161903"
] | [
"32492081"
] | [
"ERdj8 governs the size of autophagosomes during the formation process."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2212
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
2,
5,
1,
3
] | 6 | true | Domain | DnaJ homolog subfamily C member 16, C-terminal domain | DnaJ homolog subfamily C member 16, C-terminal domain | DJC16_C | 8 |
IPR060276 | 60,276 | Putative transmembrane protein, C-terminal domain | TM-like_C | Domain | 3,739 | false | false | This entry represents the Thioredoxin-like domain at the C-terminal in putative transmembrane proteins and other uncharacterised proteins mostly found in Pseudomonadati. This domain belongs to the Thioredoxin-like superfamily . Members of this superfamily are small redox-active proteins that mediate thiol-disulfide exc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26971"
] | [
"TM-like_Thioredoxin-like_C"
] | [
3739
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00115488"
] | [
"15558583"
] | [
"Structural classification of thioredoxin-like fold proteins."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3678,
7,
54
] | 3 | [] | [] | 0 | true | Domain | Putative transmembrane protein, C-terminal domain | Putative transmembrane protein, C-terminal domain | TM-like_C | 9 |
IPR060277 | 60,277 | CNOT10, TPR domain | CNOT10_TPR | Domain | 3,297 | false | false | This entry represents a region of tetratricopeptide repeats (TPR) in CNOT10, a component of the CCR4-NOT complex. The protein contains multiple TPR repeats (this entry and ) that likely mediate protein-protein interactions within the complex. CNOT10 is part of the CCR4-NOT complex, a major cellular mRNA deadenylase lin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27626"
] | [
"CNOT10_TPR"
] | [
3297
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-429947",
"R-BTA-6804115",
"R-DRE-6804115",
"R-GGA-429947",
"R-GGA-6804115",
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115",
"R-RNO-6804115"
] | [
"REACTOME:R-BTA-429947",
"REACTOME:R-BTA-6804115",
"REACTOME:R-DRE-6804115",
"REACTOME:R-GGA-429947",
"REACTOME:R-GGA-6804115",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115",
"REACTOME:R-RNO-6804115"
] | 11 | [
"8bfi",
"8fy3",
"8fy4"
] | 3 | [
"PUB00083182",
"PUB00090038"
] | [
"23303381",
"23221646"
] | [
"NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.",
"Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs."
] | [
2013,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Sphingobacterium"
] | [
3284,
13
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
9,
3,
4,
1,
3,
8,
9
] | 8 | true | Domain | CNOT10, TPR domain | CNOT10, TPR domain | CNOT10_TPR | 9 |
IPR060278 | 60,278 | PDI-like, thioredoxin-like domain | Thioredoxin-like_PDI | Domain | 800 | false | false | This entry represents a Thioredoxin-like domain in putative disulfide-isomerase proteins mostly found in plants. This domain belongs to the Thioredoxin-like superfamily . Members of this superfamily are small redox-active proteins that mediate thiol-disulfide exchange through a conserved active-site disulfide bond. The... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26981"
] | [
"Thioredoxin-like_PDI"
] | [
800
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00115488"
] | [
"15558583"
] | [
"Structural classification of thioredoxin-like fold proteins."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
800
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
5,
7
] | 3 | true | Domain | PDI-like, thioredoxin-like domain | PDI-like, thioredoxin-like domain | Thioredoxin-like_PDI | 7 |
IPR060279 | 60,279 | Nucleoporin NUP37, beta-propeller domain | NUP37_beta-prop | Domain | 1,038 | false | false | This entry represents the β-propeller domain of nucleoporin NUP37 from Chaetomium thermophilum and related fungal sequences, which is a component of the nuclear pore complex (NPC). The domain contains multiple WD repeats that form a β-propeller structure. The specific function of this domain remains to be determined. N... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28370"
] | [
"NUP37_N"
] | [
1038
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155871"
] | [
"21784248"
] | [
"Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1038
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Nucleoporin NUP37, beta-propeller domain | Nucleoporin NUP37, beta-propeller domain | NUP37_beta-prop | 6 |
IPR060280 | 60,280 | ZNF608/609, beta-sheet domain | ZNF608/609_beta_dom | Domain | 3,001 | false | false | This entry represents a small β-sheet domain found in Zinc finger proteins 608 and 609 (ZNF608/ZNF609) and similar animal transcription factors. ZNF608 represses the expression of ZNF609, which in turn represses recombination-activating gene 1 (Rag1) and Rag2 expression in thymocytes [ ]. Interestingly, ZNF609 generate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27627"
] | [
"ZNF609_beta"
] | [
3001
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090416",
"PUB00090417",
"PUB00090418",
"PUB00090481",
"PUB00162436"
] | [
"28344082",
"27903978",
"28824721",
"23076336",
"28041881"
] | [
"Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.",
"Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.",
"Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.",
... | [
2017,
2017,
2017,
2013,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3001
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
11,
5,
5,
4
] | 5 | true | Domain | ZNF608/609, beta-sheet domain | ZNF608/609, beta-sheet domain | ZNF608/609_beta_dom | 3 |
IPR060281 | 60,281 | Synergin gamma, spectrin-like domain | Spectrin-like_SYNRG | Domain | 2,531 | false | false | This entry represents a Spectrin-like domain in synergin gamma proteins. This domain is usually found associated with . It is not present in C. elegans orthologues. Synergin gamma proteins are involved in endocytosis and membrane trafficking at the trans-Golgi network (TGN). They function by linking the adapter protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26996"
] | [
"Spectrin-like_SYNRG"
] | [
2531
] | 1 | [] | [] | [] | 0 | [
"2mx7"
] | 1 | [
"PUB00069887",
"PUB00073158"
] | [
"15758025",
"12538641"
] | [
"The aftiphilin/p200/gamma-synergin complex.",
"EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking."
] | [
2005,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2531
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
19,
3,
4,
6
] | 4 | true | Domain | Synergin gamma, spectrin-like domain | Synergin gamma, spectrin-like domain | Spectrin-like_SYNRG | 2 |
IPR060282 | 60,282 | RecBCD enzyme subunit RecC, fourth domain | RecC_4th | Domain | 8,114 | false | false | This entry represents the fourth domain of RecBCD enzyme subunit RecC. This domain is found in bacteria and spans approximately residues 429-631 in some family members. The exodeoxyribonuclease V enzyme or RecBCD enzyme is a multisubunit enzyme comprised of the proteins RecB ( ), RecC (this family) and RecD ( ). This e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27451"
] | [
"RecC_4th"
] | [
8114
] | 1 | [] | [] | [] | 0 | [
"1w36",
"3k70",
"5ld2",
"5mbv",
"6sjb",
"6sje",
"6sjf",
"6sjg",
"6t2u",
"6t2v",
"7mr0",
"7mr1",
"7mr2",
"7mr3",
"7mr4",
"8b1r",
"8b1t",
"8b1u"
] | 18 | [
"PUB00008491",
"PUB00109221",
"PUB00163311"
] | [
"7746848",
"31907455",
"2593567"
] | [
"The initiation and control of homologous recombination in Escherichia coli.",
"A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.",
"[Diagnosis and treatment of recurrences of peptic ulcer after selective proximal vagotomy]."
] | [
1995,
2020,
1989
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8019,
12,
83
] | 3 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
1,
1
] | 2 | true | Domain | RecBCD enzyme subunit RecC, fourth domain | RecBCD enzyme subunit RecC, fourth domain | RecC_4th | 6 |
IPR060283 | 60,283 | FAM193A, N-terminal domain | FAM193A_N | Domain | 1,935 | false | false | This entry represents the N-terminal domain of FAM193A, which are uncharacterised proteins from animals. This domain contains α-helices arranged in a bundle. This domain is not present in FAM193B and it can be found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27002"
] | [
"FAM193A_N"
] | [
1935
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1935
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
2,
3,
4
] | 5 | true | Domain | FAM193A, N-terminal domain | FAM193A, N-terminal domain | FAM193A_N | 5 |
IPR060284 | 60,284 | Potassium efflux system KefB/KefC-like, C-terminal domain | KefB/KefC-like_C | Domain | 7,860 | false | false | This entry represents the C-terminal domain of the glutathione-regulated potassium-efflux system protein KefB and KefC and similar proteins mainly found in proteobacteria. KefB is the pore-forming subunit of a potassium efflux system that confers protection against electrophiles and catalyses potassium/proton antiport.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27452"
] | [
"KefB_C"
] | [
7860
] | 1 | [] | [] | [] | 0 | [
"3eyw",
"3l9w",
"3l9x",
"5nc8",
"8bxg",
"8by2",
"9emb"
] | 7 | [
"PUB00003817",
"PUB00053157",
"PUB00055099",
"PUB00061574",
"PUB00061650",
"PUB00061651"
] | [
"2046548",
"11053405",
"8594323",
"21041667",
"9312097",
"21742892"
] | [
"The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli.",
"Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli.",
"Potassium channel activation by glutathio... | [
1991,
2000,
1995,
2010,
1997,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcinaceae",
"metagenomes"
] | [
7826,
10,
3,
21
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Potassium efflux system KefB/KefC-like, C-terminal domain | Potassium efflux system KefB/KefC-like, C-terminal domain | KefB/KefC-like_C | 3 |
IPR060285 | 60,285 | Protein-arginine kinase McsB, C-terminal domain | McsB_C | Domain | 3,228 | false | false | This entry represents the C-terminal helical domain of protein-arginine kinase McsB. The C-terminal domain contains the phosphoarginine-binding pocket and is involved in allosteric regulation, with the RDXXRA motif being important for binding phosphoarginine-containing polypeptides. This domain is found in Gram-positiv... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27454"
] | [
"McsB_C"
] | [
3228
] | 1 | [
"EC"
] | [
"2.7.14.1"
] | [
"EC:2.7.14.1"
] | 1 | [
"6fh1",
"6fh2",
"6fh3",
"6tv6",
"8gqd",
"8wtb"
] | 6 | [
"PUB00052996",
"PUB00081098",
"PUB00081099",
"PUB00081100",
"PUB00081101"
] | [
"19498169",
"22517742",
"21622759",
"19226326",
"24263382"
] | [
"McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR.",
"Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis.",
"Activity control of the ClpC adaptor McsB in Bacillus subtilis.",
"McsA and B mediate the delocalization of compete... | [
2009,
2012,
2011,
2009,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"Thermococcus litoralis",
"metagenomes"
] | [
3168,
6,
2,
52
] | 4 | [] | [] | 0 | true | Domain | Protein-arginine kinase McsB, C-terminal domain | Protein-arginine kinase McsB, C-terminal domain | McsB_C | 9 |
IPR060287 | 60,287 | Centrosomal protein of 295 kDa-like | CEP295-like | Domain | 2,547 | false | false | This entry represents the N-terminal region of the Centrosomal protein of 295 kDa and the full-length CEP295 N-terminal-like protein (CEP295NL), also known as differential display clone 8 (DDC8). CEP295 was originally identified as a gene expressed during spermatogenesis [ ]. CEP295NL localises to motile cilia in matur... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28375"
] | [
"CEP295NL"
] | [
2547
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060827",
"PUB00161873",
"PUB00161874",
"PUB00161875",
"PUB00162500",
"PUB00162501"
] | [
"20844083",
"9237247",
"19706271",
"16985004",
"25131205",
"38154379"
] | [
"Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731.",
"Differential display to identify and isolate novel genes expressed during spermatogenesis.",
"Male germ cell-specific protein Trs4 binds to multiple proteins.",
"Potential regulato... | [
2010,
1997,
2009,
2007,
2014,
2024
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2547
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
5,
11
] | 4 | true | Domain | Centrosomal protein of 295 kDa-like | Centrosomal protein of 295 kDa-like | CEP295-like | 5 |
IPR060288 | 60,288 | GDP-mannose pyrophosphatase NudK, N-terminal domain | NudK_N | Domain | 4,941 | false | false | This entry represents the N-terminal domain of GDP-mannose pyrophosphatase NudK. This N-terminal domain is composed of a three-stranded β meander and is involved in domain swapping between the two monomers in the dimer. Residues from both chains contribute to the active site through this domain-swapping mechanism. The ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27456"
] | [
"NudK_N"
] | [
4941
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 11 | [
"1viu",
"3o52",
"3o61",
"3o69",
"3o6z"
] | 5 | [
"PUB00043005",
"PUB00158831"
] | [
"16766526",
"21638333"
] | [
"Three new Nudix hydrolases from Escherichia coli.",
"Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition."
] | [
2006,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4931,
4,
6
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | GDP-mannose pyrophosphatase NudK, N-terminal domain | GDP-mannose pyrophosphatase NudK, N-terminal domain | NudK_N | 1 |
IPR060290 | 60,290 | BOS1/GOSR2/MEM11, N-terminal domain | BOS1_GOSR2_MEM11-like_N | Domain | 4,452 | false | false | This entry represents the N-terminal in BOS1/GOSR2/MEM11 proteins. BOS1/GOSR2/MEM11 proteins are involved in intracellular protein transport, specifically facilitating the movement of proteins between the endoplasmic reticulum (ER) and the Golgi complex, as well as within the Golgi apparatus itself. These proteins func... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27021"
] | [
"BOS1_GOSR2_MEM11-like_N"
] | [
4452
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-204005",
"R-CEL-5694530",
"R-CEL-6807878",
"R-CEL-6811438",
"R-DME-204005",
"R-DME-5694530",
"R-DME-6807878",
"R-DME-6811438",
"R-HSA-204005",
"R-HSA-381038",
"R-HSA-5694530",
"R-HSA-6807878",
"R-HSA-6811438",
"R-MMU-204005",
"R-MMU-5694530",
"R-MMU-6807878",
"R-MMU-6811438",
... | [
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-5694530",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811438",
"REACTOME:R-DME-204005",
"REACTOME:R-DME-5694530",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811438",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-381038",
"REACTOME:R-HSA-5694530",
"REACTOME:R-... | 27 | [] | 0 | [
"PUB00062424",
"PUB00161835"
] | [
"9349823",
"9094723"
] | [
"A SNARE involved in protein transport through the Golgi apparatus.",
"Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells."
] | [
1997,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Dyadobacter koreensis",
"Eukaryota"
] | [
1,
4451
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
1,
1,
30,
2,
1,
2,
5,
1,
1,
2
] | 12 | true | Domain | BOS1/GOSR2/MEM11, N-terminal domain | BOS1/GOSR2/MEM11, N-terminal domain | BOS1_GOSR2_MEM11-like_N | 2 |
IPR060291 | 60,291 | Bacteriophage T7 protein kinase 0.7 | Phage_T7_kinase | Family | 320 | false | false | This entry represents protein kinase 0.7 found in T7-like bacteriophages. This serine/threonine kinase modulates host metabolism to favour virus replication by phosphorylating multiple host proteins [ , ]. Key targets include RNA polymerase subunits RpoC and RpoB, RNA degradosome components RNase E and RhlB, and transl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27024"
] | [
"Phage_T7_kinase"
] | [
320
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00056594",
"PUB00162252"
] | [
"3291115",
"12368087",
"12471243",
"15078142",
"15320712",
"11722741",
"1101258"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"High-throughput structural biology in drug discovery: protein kinases.",
"Creating chemical dive... | [
1988,
2002,
2002,
2004,
2004,
2001,
1975
] | 7 | [] | [
"IPR014374"
] | 0 | 1 | 0 | [
"Pseudomonadati",
"Viruses"
] | [
10,
310
] | 2 | [] | [] | 0 | true | Family | Bacteriophage T7 protein kinase 0.7 | Bacteriophage T7 protein kinase 0.7 | Phage_T7_kinase | 5 |
IPR060292 | 60,292 | TRPM8 channel-associated factor, alpha-helical domain | TCAF_helical | Domain | 1,705 | false | false | This entry represents an α-helical domain in TCAF proteins. This domain is found in the middle region, between and . TCAF proteins are involved in the regulation of the TRPM8 cation channel activity. These proteins are either positively or negatively regulate TRPM8, influencing its recruitment to the cell surface. This... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27027"
] | [
"TCAF_helical"
] | [
1705
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1705
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
9,
3,
13
] | 4 | true | Domain | TRPM8 channel-associated factor, alpha-helical domain | TRPM8 channel-associated factor, alpha-helical domain | TCAF_helical | 5 |
IPR060293 | 60,293 | Trehalose phosphorylase-like, N-terminal | TreT-like_N | Domain | 1,503 | false | false | This entry represents the N-terminal domain in putative Trehalose phosphorylase (TreT) proteins mostly found in fungi. This domain adopts a RNase-like fold. The core architecture typically features a central five-stranded β-sheet flanked by several α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27036"
] | [
"TreT-like_N"
] | [
1503
] | 1 | [
"EC",
"METACYC"
] | [
"2.4.1.231",
"PWY-2723"
] | [
"EC:2.4.1.231",
"METACYC:PWY-2723"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1503
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Trehalose phosphorylase-like, N-terminal | Trehalose phosphorylase-like, N-terminal | TreT-like_N | 3 |
IPR060294 | 60,294 | Acyl-CoA N-acyltransferase VerG, N-terminal domain | VerG_N | Domain | 971 | false | false | This entry represents the N-terminal domain of VerG, an acyl-CoA N- acyltransferase involved in verrucosidin biosynthesis in fungi. While the full-length VerG protein is involved in verrucosidin biosynthesis, the specific function of this N-terminal domain remains to be determined. VerG is part of a gene cluster that m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28379"
] | [
"VerG_N"
] | [
971
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100792"
] | [
"34093475"
] | [
"CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in <i>Penicillium polonicum</i>."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
971
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Acyl-CoA N-acyltransferase VerG, N-terminal domain | Acyl-CoA N-acyltransferase VerG, N-terminal domain | VerG_N | 3 |
IPR060297 | 60,297 | VSTM5, C-terminal region | VSTM5_C | Domain | 781 | false | false | This entry represents the C-terminal helical region of V-set and transmembrane domain-containing protein 5 (VSTM5), found in mammals. This domain spans the transmembrane region and cytoplasmic tail of VSTM5. While the full-length protein has established roles in neuronal development, the specific function of this C-ter... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28389"
] | [
"VSTM5_C"
] | [
781
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155122"
] | [
"27683913"
] | [
"Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
781
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
2
] | 4 | true | Domain | VSTM5, C-terminal region | VSTM5, C-terminal region | VSTM5_C | 3 |
IPR060300 | 60,300 | HAUS3, coiled-coil | HAUS3_CC | Domain | 1,206 | false | false | This entry represents a coiled coil region in animal HAUS3 proteins. HAUS3 is involved in critical cellular processes such as mitotic spindle assembly, centrosome integrity maintenance, and cytokinesis completion. As a component of the HAUS augmin-like complex, it plays a pivotal role in interacting with the gamma-tubu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27044"
] | [
"HAUS3_CC"
] | [
1206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [
"7sqk",
"8at2",
"8at3",
"8at4",
"8fck"
] | 5 | [
"PUB00056753",
"PUB00056754"
] | [
"19369198",
"19427217"
] | [
"The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.",
"HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity."
] | [
2009,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1206
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
4
] | 4 | true | Domain | HAUS3, coiled-coil | HAUS3, coiled-coil | HAUS3_CC | 6 |
IPR060301 | 60,301 | CCPG1/PBIP1, C-terminal domain | CCPG1/PBIP1_C | Domain | 2,785 | false | false | This entry represents the C-terminal domain of human cell cycle progression protein 1 (CCPG1), Pre-B-cell leukemia transcription factor-interacting protein 1 (PBIP1) and similar proteins from vertebrates. This domain is located in the lumenal region of the protein following the transmembrane helix [ ]. The specific fun... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27631"
] | [
"CCPG1_C"
] | [
2785
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053649",
"PUB00055477",
"PUB00055479",
"PUB00074594"
] | [
"15642098",
"10825160",
"17043237",
"9383053"
] | [
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.",
"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.",
"An inherent role of microtubule network in the action of nuclear receptor.",
"Human C... | [
2005,
2000,
2006,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2785
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
7,
3,
14
] | 4 | true | Domain | CCPG1/PBIP1, C-terminal domain | CCPG1/PBIP1, C-terminal domain | CCPG1/PBIP1_C | 3 |
IPR060302 | 60,302 | CCPG1/PBIP1 helical domain | CCPG1/PBIP_helical | Domain | 1,978 | false | false | This entry represents a domain found towards the N-terminal end in human cell cycle progression protein 1 (CCPG1), Pre-B-cell leukemia transcription factor-interacting protein 1 (PBIP1) and similar proteins from vertebrates. This domain contains an all-helical fold. CCPG1 is a type II membrane protein localised to cyto... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27636"
] | [
"CCPG1_N"
] | [
1978
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053649",
"PUB00055477",
"PUB00055479",
"PUB00074594"
] | [
"15642098",
"10825160",
"17043237",
"9383053"
] | [
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.",
"Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.",
"An inherent role of microtubule network in the action of nuclear receptor.",
"Human C... | [
2005,
2000,
2006,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota"
] | [
3,
3,
1972
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
3,
18
] | 4 | true | Domain | CCPG1/PBIP1 helical domain | CCPG1/PBIP1 helical domain | CCPG1/PBIP_helical | 3 |
IPR060303 | 60,303 | HAUS3, C-terminal | HAUS3_C | Domain | 1,676 | false | false | This entry represents the C-terminal domain in HAUS3 proteins. HAUS3 is involved in critical cellular processes such as mitotic spindle assembly, centrosome integrity maintenance, and cytokinesis completion. As a component of the HAUS augmin-like complex, it plays a pivotal role in interacting with the gamma-tubulin ri... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27045"
] | [
"HAUS3_C"
] | [
1676
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [
"7sqk",
"8at2",
"8at3",
"8at4",
"8fck",
"9na8",
"9na9",
"9nba",
"9nbb",
"9nbd"
] | 10 | [
"PUB00056753",
"PUB00056754"
] | [
"19369198",
"19427217"
] | [
"The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.",
"HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity."
] | [
2009,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1676
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
1,
1,
5,
2,
8
] | 7 | true | Domain | HAUS3, C-terminal | HAUS3, C-terminal | HAUS3_C | 6 |
IPR060304 | 60,304 | Glycerol-3-phosphate acyltransferase PlsB, N-terminal domain | PlsB_N | Domain | 4,683 | false | false | This entry represents the N-terminal domain of glycerol-3-phosphate acyltransferase PlsB. This N-terminal domain spans approximately residues 8-210 and precedes the main catalytic acyltransferase domain containing the essential HXXXXD motif. The enzyme is found in Gammaproteobacteria. The specific function of this N-te... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27464"
] | [
"PlsB_N"
] | [
4683
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.1.15",
"PWY-5667",
"PWY-6453",
"PWY-7411",
"PWY-7587",
"PWY-8051",
"PWY-8053",
"PWY-8055"
] | [
"EC:2.3.1.15",
"METACYC:PWY-5667",
"METACYC:PWY-6453",
"METACYC:PWY-7411",
"METACYC:PWY-7587",
"METACYC:PWY-8051",
"METACYC:PWY-8053",
"METACYC:PWY-8055"
] | 8 | [] | 0 | [
"PUB00053573",
"PUB00057466",
"PUB00098816",
"PUB00098817"
] | [
"16294310",
"16949372",
"30813330",
"32817111"
] | [
"A protein network for phospholipid synthesis uncovered by a variant of the tandem affinity purification method in Escherichia coli.",
"Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.",
"Transcriptional Regulation of Acyl-CoA:Glycerol-<i>sn</i>-3-Phosphate Acyltransferases."... | [
2006,
2006,
2019,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
4651,
5,
27
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Glycerol-3-phosphate acyltransferase PlsB, N-terminal domain | Glycerol-3-phosphate acyltransferase PlsB, N-terminal domain | PlsB_N | 4 |
IPR060307 | 60,307 | Zinc finger transcription factor Trps1, third C2H2 zinc finger | Znf_C2H2_Trps1_3rd | Domain | 1,185 | false | false | This entry represents the third C2H2 zinc finger found in human Zinc finger transcription factor Trps1 and related proteins mainly from animals. Trps1 functions primarily as a transcriptional repressor. It binds specifically to GATA sequences and plays a crucial role in repressing the expression of GATA-regulated genes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27047"
] | [
"Znf_C2H2_Trps1_3rd"
] | [
1185
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00137115",
"PUB00162439",
"PUB00162440",
"PUB00162441"
] | [
"12885770",
"11285235",
"19389374",
"17391059"
] | [
"The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.",
"Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.",
"Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activ... | [
2003,
2001,
2009,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1185
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
10,
8
] | 4 | true | Domain | Zinc finger transcription factor Trps1, third C2H2 zinc finger | Zinc finger transcription factor Trps1, third C2H2 zinc finger | Znf_C2H2_Trps1_3rd | 9 |
IPR060308 | 60,308 | C3orf18/SIM29 domain | C3orf18_dom | Domain | 1,462 | false | false | This entry represents an helical domain found in human Uncharacterized protein C3orf18, Small integral membrane protein 29 (SIM29) and similar animal proteins. These proteins contain an N-terminal disordered region and this helical domain which includes the transmembrane helix. The function of this domain remains to be... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27898"
] | [
"C3orf18_N"
] | [
1462
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dactylosporangium roseum",
"Eukaryota"
] | [
1,
1461
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
6,
7,
4
] | 4 | true | Domain | C3orf18/SIM29 domain | C3orf18/SIM29 domain | C3orf18_dom | 9 |
IPR060310 | 60,310 | Cytoplasmic filament protein A, C-terminal domain | CfpA_C | Domain | 58 | false | false | This entry represents the C-terminal domain of cytoplasmic filament proteins found in spirochaetes, including CfpA from Treponema pallidum. The specific function of this domain remains to be determined CfpA is a component of cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27473"
] | [
"CfpA_C"
] | [
58
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106042"
] | [
"8655496"
] | [
"Characterization of the cytoplasmic filament protein gene (cfpA) of Treponema pallidum subsp. pallidum."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Protostomia"
] | [
54,
4
] | 2 | [] | [] | 0 | true | Domain | Cytoplasmic filament protein A, C-terminal domain | Cytoplasmic filament protein A, C-terminal domain | CfpA_C | 4 |
IPR060312 | 60,312 | TP_0593-like, N-terminal domain | TP_0593-like_N | Domain | 53 | false | false | This entry represents the PAS domain at the N-terminal found in TP_0593, an uncharacterised protein from Treponema pallidum. TP_0593 is a 677 amino acid multi-pass membrane protein with three predicted transmembrane helices localised to the cell membrane. The protein is annotated in COG3064 and contains a disordered re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27485"
] | [
"TP_0593_N"
] | [
53
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
53
] | 1 | [] | [] | 0 | true | Domain | TP_0593-like, N-terminal domain | TP_0593-like, N-terminal domain | TP_0593-like_N | 1 |
IPR060313 | 60,313 | TP_0752-like, middle domain | TP_0752-like_M | Domain | 43 | false | false | This entry represents the middle domain of TP_0752, an uncharacterised protein from Treponema pallidum. TP_0752 is a 380 amino acid precursor protein with a signal peptide and contains a C-terminal SPOR domain ( ) involved in peptidoglycan binding. This domain is found exclusively in Spirochaetales. The specific functi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27498"
] | [
"TP_0752_M"
] | [
43
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spirochaetales"
] | [
43
] | 1 | [] | [] | 0 | true | Domain | TP_0752-like, middle domain | TP_0752-like, middle domain | TP_0752-like_M | 3 |
IPR060314 | 60,314 | TdpA, C-terminal domain | TdpA_C | Domain | 69 | false | false | This entry represents the C-terminal domain of TdpA proteins. TdpA is a 53 kDa membrane antigen found in Treponema denticola that is localised to the cell membrane as a lipoprotein. The specific function of this domain remains to be determined. This domain can be found in other positions in uncharacterised bacterial pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27500"
] | [
"TdpA_C"
] | [
69
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Spirochaetales"
] | [
69
] | 1 | [] | [] | 0 | true | Domain | TdpA, C-terminal domain | TdpA, C-terminal domain | TdpA_C | 6 |
IPR060315 | 60,315 | Y4fE | Y4fE | Family | 131 | false | false | This entry represents a family of uncharacterised proteins from alphaproteobacteria, including Uncharacterized protein y4fE. Members contain an N-terminal signal peptide. The function remains to be determined. Proteins in this entry are predicted to show an α/β fold similar to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27501"
] | [
"Y4fE"
] | [
131
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"marine sediment metagenome"
] | [
130,
1
] | 2 | [] | [] | 0 | true | Family | Y4fE | Y4fE | Y4fE | 7 |
IPR060316 | 60,316 | MadH, C-terminal domain | MadH_C | Domain | 80 | false | false | This entry represents the C-terminal domain of MadH proteins. The specific function of this domain remains to be determined. MadH is an ACP-SH acetate ligase that functions as part of the biotin-dependent malonate decarboxylase multienzyme complex [ , ]. The protein catalyses the formation of acetyl-[ACP] from holo-[AC... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27502"
] | [
"MadH_C"
] | [
80
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043060",
"PUB00162147"
] | [
"9128730",
"8664258"
] | [
"Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.",
"The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5\"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group."
] | [
1997,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum"
] | [
75,
5
] | 2 | [] | [] | 0 | true | Domain | MadH, C-terminal domain | MadH, C-terminal domain | MadH_C | 5 |
IPR060317 | 60,317 | Zinc finger transcription factor Trps1, second C2H2 zinc finger | Znf_C2H2_Trps1_2nd | Domain | 1,244 | false | false | This entry represents the second C2H2 zinc finger found in the human Zinc finger transcription factor Trps1 and related proteins mainly from animals. Trps1 functions primarily as a transcriptional repressor. It binds specifically to GATA sequences and plays a crucial role in repressing the expression of GATA-regulated ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27065"
] | [
"Znf_C2H2_Trps1_2nd"
] | [
1244
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00137115",
"PUB00162439",
"PUB00162440",
"PUB00162441"
] | [
"12885770",
"11285235",
"19389374",
"17391059"
] | [
"The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.",
"Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.",
"Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activ... | [
2003,
2001,
2009,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1244
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
10,
8
] | 4 | true | Domain | Zinc finger transcription factor Trps1, second C2H2 zinc finger | Zinc finger transcription factor Trps1, second C2H2 zinc finger | Znf_C2H2_Trps1_2nd | 3 |
IPR060318 | 60,318 | Zinc finger transcription factor Trps1, fourth C2H2 zinc finger | Znf_C2H2_Trps1_4th | Domain | 1,091 | false | false | This entry represents the fourth C2H2 zinc finger found in human Zinc finger transcription factor Trps1 and related proteins mainly from animals. Trps1 functions primarily as a transcriptional repressor. It binds specifically to GATA sequences and plays a crucial role in repressing the expression of GATA-regulated gene... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27082"
] | [
"Znf_C2H2_Trps1_4th"
] | [
1091
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00137115",
"PUB00162439",
"PUB00162440",
"PUB00162441"
] | [
"12885770",
"11285235",
"19389374",
"17391059"
] | [
"The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.",
"Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.",
"Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activ... | [
2003,
2001,
2009,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1091
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
7,
6
] | 4 | true | Domain | Zinc finger transcription factor Trps1, fourth C2H2 zinc finger | Zinc finger transcription factor Trps1, fourth C2H2 zinc finger | Znf_C2H2_Trps1_4th | 9 |
IPR060319 | 60,319 | Rv3811-like, N-terminal galactose-binding domain-like | Rv3811-like_N | Domain | 3,182 | false | false | This entry represents the N-terminal domain of Mycobacterium tuberculosis Rv3811 ( ) and related proteins mainly found in actinomycetes. This domain adopts a galactose-binding domain-like fold and is found at the N-terminal of a larger multi-domain protein. The full-length Rv3811 protein is a 539-residue conserved hypo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27503"
] | [
"Rv3811_N"
] | [
3182
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
3161,
21
] | 2 | [] | [] | 0 | true | Domain | Rv3811-like, N-terminal galactose-binding domain-like | Rv3811-like, N-terminal galactose-binding domain-like | Rv3811-like_N | 8 |
IPR060320 | 60,320 | DG1062/SHA-B, N-terminal domain | DG1062/SHA-B_N | Domain | 1,228 | false | false | This entry represents the N-terminal domain found in DG1062 which is a CudA-like protein. This domain adopts an immunoglobulin-like fold and is found at the N-terminal region of transcriptional regulators including CudA from Dictyostelium discoideum and is the second domain in SHA/SHB from Arabidopsis thaliana. The Cud... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28397"
] | [
"DG1062_N"
] | [
1228
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161901"
] | [
"9226443"
] | [
"cudA: a Dictyostelium gene with pleiotropic effects on cellular differentiation and slug behaviour."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1228
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
11
] | 3 | true | Domain | DG1062/SHA-B, N-terminal domain | DG1062/SHA-B, N-terminal domain | DG1062/SHA-B_N | 2 |
IPR060321 | 60,321 | Prephenate dehydrogenase [NADP(+)], C-terminal domain | Tyr1_C | Domain | 1,935 | false | false | This domain is found at the C-terminal end of the yeast probable prephenate dehydrogenase [NADP(+)] (Tyr1) and related proteins. This domain is found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27505"
] | [
"6PGD_Tyr1_C"
] | [
1935
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Eukaryota"
] | [
147,
1788
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Domain | Prephenate dehydrogenase [NADP(+)], C-terminal domain | Prephenate dehydrogenase [NADP(+)], C-terminal domain | Tyr1_C | 8 |
IPR060322 | 60,322 | ATRAID-like, EGF-like domain | EGF_ATRAID_C | Domain | 923 | false | false | This domain is found towards the C-terminal end of human All-trans retinoic acid-induced differentiation factor (ATRAID) and related animal proteins. This domain contains an EGF-like fold. ATRAID (All-trans retinoic acid-induced differentiation factor), also known as APR3, is a membrane protein that functions as a prol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27506"
] | [
"EGF_ATRAID_C"
] | [
923
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092891",
"PUB00092892",
"PUB00161813"
] | [
"21723284",
"17524364",
"29745899"
] | [
"NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation.",
"Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.",
"Identification of a transporter complex responsible for the cytosolic entry ... | [
2011,
2007,
2018
] | 3 | [
"IPR000742"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
923
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
4,
6
] | 4 | true | Domain | ATRAID-like, EGF-like domain | ATRAID-like, EGF-like domain | EGF_ATRAID_C | 1 |
IPR060323 | 60,323 | Calsyntenin, N-terminal domain | Ig_CLSTN_N | Domain | 5,275 | false | false | This immunoglobulin-like (Ig-like) domain is found twice at the N-terminal of animal Calsyntenin (CLSTN) proteins; this entry represents the first one and the second is represented in . Members of this family bind to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. They also function a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28399"
] | [
"Ig_CLSTN"
] | [
5275
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098911",
"PUB00162068",
"PUB00162069",
"PUB00162070",
"PUB00162071",
"PUB00162072",
"PUB00162073",
"PUB00162074",
"PUB00162075",
"PUB00162076"
] | [
"12972431",
"24613359",
"26171716",
"31529526",
"31043739",
"24094106",
"32434929",
"33672967",
"35420982",
"36477540"
] | [
"Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.",
"Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.",
"Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Red... | [
2003,
2014,
2016,
2020,
2019,
2013,
2020,
2021,
2022,
2023
] | 10 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
5275
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
11,
3,
14,
5,
13
] | 6 | true | Domain | Calsyntenin, N-terminal domain | Calsyntenin, N-terminal domain | Ig_CLSTN_N | 6 |
IPR060324 | 60,324 | ANTKMT, N-terminal | ANTKMT_N | Domain | 907 | false | false | This entry represents the N-terminal region of adenine nucleotide translocase lysine N-methyltransferase (ANTKMT). This entry covers an N-terminal sequence (NTS) and a transmembrane region that is responsible for mitochondrial localisation. The specific function of this N-terminal domain is for mitochondrial targeting ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28400"
] | [
"ANTKMT_N"
] | [
907
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161791"
] | [
"31213526"
] | [
"Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
907
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
2,
4
] | 4 | true | Domain | ANTKMT, N-terminal | ANTKMT, N-terminal | ANTKMT_N | 8 |
IPR060325 | 60,325 | Co-chaperone DjlA, transmembrane domain | DjlA_TM | Domain | 5,009 | false | false | This entry represents the N-terminal transmembrane domain of co-chaperone protein DjlA and similar proteins from gammaproteobacteria. This domain contains two transmembrane helices with glycine zipper motifs that are involved in protein dimerisation. The transmembrane domain serves as the dimerisation domain and anchor... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27507"
] | [
"DjlA_TM"
] | [
5009
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053678",
"PUB00053679",
"PUB00054967"
] | [
"11758943",
"11106641",
"9364917"
] | [
"Characterization of the RcsC-->YojN-->RcsB phosphorelay signaling pathway involved in capsular synthesis in Escherichia coli.",
"DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.",
"Positive control of the two-component Rc... | [
2001,
2001,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4916,
5,
88
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Co-chaperone DjlA, transmembrane domain | Co-chaperone DjlA, transmembrane domain | DjlA_TM | 7 |
IPR060327 | 60,327 | MHP1/GIP3/HER1, C-terminal domain | MHP1/GIP3/HER1_C | Domain | 983 | false | false | This entry represents the C-terminal region of MAP-homologous protein 1 (MHP1), HER1 and GIP3 from yeast and related fungal sequences. The specific function of this region remains to be determined. MHP1 is essential for the formation and stabilisation of microtubules, binds to microtubules in vitro, and localises to cy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28401"
] | [
"MHP1_C"
] | [
983
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060265",
"PUB00162157",
"PUB00162502"
] | [
"16537909",
"8947554",
"18667535"
] | [
"Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7.",
"MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function.",
"Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevi... | [
2006,
1996,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
983
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3
] | 1 | true | Domain | MHP1/GIP3/HER1, C-terminal domain | MHP1/GIP3/HER1, C-terminal domain | MHP1/GIP3/HER1_C | 2 |
IPR060328 | 60,328 | Anosmin-1, immunoglobulin-like domain | Ig_ANOS1 | Domain | 1,972 | false | false | This entry represents a immunoglobulin-like (Ig-like) domain found in Anosmin-1 (ANOS1) and related proteins. In ANOS1 from human, this domain is found twice. Anosmin-1 (ANOS1) is an extracellular matrix protein that functions in the development of craniofacial structures [ ]. It has been linked to hereditary Kallmann'... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28407"
] | [
"Ig_ANOS1"
] | [
1972
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-190373",
"R-HSA-5654726"
] | [
"REACTOME:R-HSA-190373",
"REACTOME:R-HSA-5654726"
] | 2 | [
"1zlg"
] | 1 | [
"PUB00057207",
"PUB00092979",
"PUB00092980"
] | [
"19696444",
"15548653",
"29277616"
] | [
"Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.",
"Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.",
"Anosmin-1 is essenti... | [
2009,
2004,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1972
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens"
] | [
2,
8,
2
] | 3 | true | Domain | Anosmin-1, immunoglobulin-like domain | Anosmin-1, immunoglobulin-like domain | Ig_ANOS1 | 6 |
IPR060330 | 60,330 | E3 ubiquitin-protein ligase RNF216, tri-helical domain | RNF216_N | Domain | 840 | false | false | This entry represents a tri-helical domain found towards the N-terminal of E3 ubiquitin-protein ligase RNF216 (RING finger protein 216), also known as TRIAD3A. The specific function of this domain remains to be determined. The very N-terminal region contains multiple disordered regions and is subject to extensive sumoy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28408"
] | [
"RNF216_N"
] | [
840
] | 1 | [
"REACTOME"
] | [
"R-HSA-936440"
] | [
"REACTOME:R-HSA-936440"
] | 1 | [] | 0 | [
"PUB00103513",
"PUB00103514",
"PUB00103515",
"PUB00103516",
"PUB00103517",
"PUB00103518",
"PUB00103519",
"PUB00103520",
"PUB00103521",
"PUB00103522",
"PUB00161507"
] | [
"23656588",
"15107846",
"25841028",
"16968706",
"15367624",
"11854271",
"19893624",
"25484083",
"21270397",
"24945773",
"34998453"
] | [
"Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.",
"Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.",
"RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.",
"Triad3A regulates ubiquitination and proteasomal degradation of RIP1... | [
2013,
2004,
2015,
2006,
2004,
2002,
2009,
2014,
2011,
2014,
2022
] | 11 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
840
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
4
] | 4 | true | Domain | E3 ubiquitin-protein ligase RNF216, tri-helical domain | E3 ubiquitin-protein ligase RNF216, tri-helical domain | RNF216_N | 7 |
IPR060331 | 60,331 | ATR-interacting protein, N-terminal | ATRIP_N | Domain | 853 | false | false | This entry represents the N-terminal region of ATR-interacting protein (ATRIP), a component of the ATR-ATRIP DNA damage-sensing kinase complex. The N-terminal region contains extensive disordered regions and a coiled-coil domain. This region includes the CINP interaction domain which is important for genome maintenance... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28409"
] | [
"ATRIP_N"
] | [
853
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6783310",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6783310",
"R-MMU-6804756",
"R-MMU-69473"
] | [
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-9709570",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5693607",
"REACTOME:R-... | 14 | [
"5yz0",
"9l43",
"9l45",
"9l46",
"9l4c",
"9l4f"
] | 6 | [
"PUB00078515",
"PUB00161814",
"PUB00161815"
] | [
"12791985",
"11721054",
"19889979"
] | [
"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.",
"ATR and ATRIP: partners in checkpoint signaling.",
"Functional genomic screens identify CINP as a genome maintenance protein."
] | [
2003,
2001,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
853
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
3,
4,
3,
4,
1
] | 5 | true | Domain | ATR-interacting protein, N-terminal | ATR-interacting protein, N-terminal | ATRIP_N | 6 |
IPR060332 | 60,332 | ATR-interacting protein, C-terminal domain | ATRIP_C | Domain | 918 | false | false | This entry represents the C-terminal domain of ATRIP (ATR-interacting protein) found in vertebrates. The C-terminal domain contains a conserved EEXXXDDL motif (residues 769-776 in human ATRIP) that is essential for interaction with the catalytic subunit PRKDC and its recruitment to sites of DNA damage [ ]. ATRIP is ess... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28426"
] | [
"ATRIP_C"
] | [
918
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6783310",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6783310",
"R-MMU-6804756",
"R-MMU-69473"
] | [
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-9709570",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5693607",
"REACTOME:R-... | 14 | [
"5yz0",
"9l43",
"9l45",
"9l46",
"9l4c",
"9l4d",
"9l4f"
] | 7 | [
"PUB00078515",
"PUB00109384",
"PUB00161814"
] | [
"12791985",
"15758953",
"11721054"
] | [
"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.",
"Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.",
"ATR and ATRIP: partners in checkpoint signaling."
] | [
2003,
2005,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
918
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
5,
4
] | 4 | true | Domain | ATR-interacting protein, C-terminal domain | ATR-interacting protein, C-terminal domain | ATRIP_C | 3 |
IPR060334 | 60,334 | Zinc finger transcription factor Trps1, fifth C2H2 zinc finger | Znf_C2H2_Trps1_5th | Domain | 1,135 | false | false | This entry represents the fifth C2H2 zinc finger found in human Zinc finger transcription factor Trps1 and related proteins mainly from animals. Trps1 functions primarily as a transcriptional repressor. It binds specifically to GATA sequences and plays a crucial role in repressing the expression of GATA-regulated genes... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27088"
] | [
"Znf_C2H2_Trps1_5th"
] | [
1135
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00137115",
"PUB00162439",
"PUB00162440",
"PUB00162441"
] | [
"12885770",
"11285235",
"19389374",
"17391059"
] | [
"The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.",
"Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.",
"Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activ... | [
2003,
2001,
2009,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1135
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
7,
6
] | 4 | true | Domain | Zinc finger transcription factor Trps1, fifth C2H2 zinc finger | Zinc finger transcription factor Trps1, fifth C2H2 zinc finger | Znf_C2H2_Trps1_5th | 8 |
IPR060336 | 60,336 | Thylakoid membrane protein Ssl2009-like, C-terminal domain | Ssl2009-like_C | Domain | 1,869 | false | false | This entry represents the C-terminal domain in thylakoid membrane protein Ssl2009 and related bacterial proteins. This domain has a helical fold. This entry also includes uncharacterised plant proteins that also belong to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27515"
] | [
"Ssl2009_C"
] | [
1869
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota",
"marine metagenome"
] | [
335,
1533,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
15,
3
] | 2 | true | Domain | Thylakoid membrane protein Ssl2009-like, C-terminal domain | Thylakoid membrane protein Ssl2009-like, C-terminal domain | Ssl2009-like_C | 3 |
IPR060337 | 60,337 | UbiB, C-terminal domain | UbiB_C | Domain | 808 | false | false | This entry represents the C-terminal of probable protein kinase UbiB. It shows an α-helical fold. This entry is specific to pseudomonadales. UbiB (also known as as AarF) is required for ubiquinone biosynthesis [ , , ]. It may function in regulating Q8 biosynthesis via its putative kinase activity [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27517"
] | [
"UbiB_C"
] | [
808
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013772",
"PUB00013848",
"PUB00068672",
"PUB00162368"
] | [
"10960098",
"11583838",
"23709220",
"34362905"
] | [
"Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis.",
"Ubiquinone biosynthesis in microorganisms.",
"ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation.",
"UbiB proteins regulate cellular CoQ ... | [
2000,
2001,
2013,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
808
] | 1 | [] | [] | 0 | true | Domain | UbiB, C-terminal domain | UbiB, C-terminal domain | UbiB_C | 4 |
IPR060338 | 60,338 | Diphthamide synthase, C-terminal domain | Diphthami_syn_C | Domain | 8,787 | false | false | This entry represents the C-terminal domain of Diphthamide synthase. Diphthamide synthase catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase catalyses the last amidation step of diphthamide biosynthesis using ammonium and ATP. Diphthamide synthase is evolutionaril... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28410"
] | [
"Diphthami_syn_2_C"
] | [
8787
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.3.1.14",
"PWY-6482",
"PWY-7546",
"R-BTA-5358493",
"R-HSA-5358493",
"R-MMU-5358493",
"R-RNO-5358493",
"R-SCE-5358493",
"R-SPO-5358493"
] | [
"EC:6.3.1.14",
"METACYC:PWY-6482",
"METACYC:PWY-7546",
"REACTOME:R-BTA-5358493",
"REACTOME:R-HSA-5358493",
"REACTOME:R-MMU-5358493",
"REACTOME:R-RNO-5358493",
"REACTOME:R-SCE-5358493",
"REACTOME:R-SPO-5358493"
] | 9 | [
"2d13",
"3rjz",
"3rk0",
"3rk1"
] | 4 | [
"PUB00073561"
] | [
"23169644"
] | [
"Chemogenomic approach identified yeast YLR143W as diphthamide synthetase."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1062,
3229,
4396,
100
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
2,
6,
1,
3,
1,
1,
4,
9,
1,
1,
10
] | 12 | true | Domain | Diphthamide synthase, C-terminal domain | Diphthamide synthase, C-terminal domain | Diphthami_syn_C | 4 |
IPR060339 | 60,339 | BAG family molecular chaperone regulator 5, BAG domain | BAG_BAG5 | Domain | 979 | false | false | This BAG domain is found in human BAG family molecular chaperone regulator 5 (BAG5) and related proteins from vertebrates. BAG5 is a co-chaperone for HSP/HSP70 proteins that functions as a nucleotide-exchange factor, promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27519"
] | [
"BAG_BAG5"
] | [
979
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3371453",
"R-MMU-3371453",
"R-RNO-3371453"
] | [
"REACTOME:R-HSA-3371453",
"REACTOME:R-MMU-3371453",
"REACTOME:R-RNO-3371453"
] | 3 | [] | 0 | [
"PUB00054479",
"PUB00161819",
"PUB00161820"
] | [
"20223214",
"35044787",
"15603737"
] | [
"The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.",
"Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation.",
"BAG5 inhibits parkin and enhances dopaminergic neuron deg... | [
2010,
2022,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
979
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
6,
3,
1,
2,
1
] | 5 | true | Domain | BAG family molecular chaperone regulator 5, BAG domain | BAG family molecular chaperone regulator 5, BAG domain | BAG_BAG5 | 9 |
IPR060340 | 60,340 | TamB, N-terminal domain | TamB_N | Domain | 8,178 | false | false | This entry represents the N-terminal region of Translocation and assembly module subunit TamB from Escherichia coli and related bacterial proteins. This long region is predicted to show a set of tandem β-sheets. It is also found twice in Uncharacterized protein BU087 from Buchnera aphidicola and related sequences. TamB... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27051"
] | [
"TamB_N"
] | [
8178
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076280",
"PUB00078749",
"PUB00078794",
"PUB00104645",
"PUB00106658",
"PUB00162312",
"PUB00162313",
"PUB00162314",
"PUB00162315"
] | [
"22466966",
"25195908",
"26243377",
"34781743",
"35226662",
"39174534",
"29129383",
"25341963",
"38913742"
] | [
"Discovery of an archetypal protein transport system in bacterial outer membranes.",
"Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490(963-1138) domain of TamB from Escherichia coli.",
"Conserved features in TamA enable interaction with Ta... | [
2012,
2014,
2015,
2021,
2022,
2024,
2017,
2014,
2024
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8109,
11,
58
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | TamB, N-terminal domain | TamB, N-terminal domain | TamB_N | 2 |
IPR060341 | 60,341 | ADGRF2P/ADGRF4-like, N-terminal domain | ADGRF2P/ADGRF4-like_N | Domain | 770 | false | false | This domain is found at the N-terminal region of a group of orphan receptors from vertebrates, including human Putative adhesion G protein-coupled receptor F2P (ADGRF2P) and ADGRF4 and similar proteins [ ]. Mouse ADGRF2 has been reported to play important roles in enamel formation [ ]. This domain is predicted to adopt... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27521"
] | [
"ADGRF2P_N"
] | [
770
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075337",
"PUB00163365"
] | [
"22837050",
"36929047"
] | [
"Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse.",
"Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process."
] | [
2012,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
770
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
5
] | 3 | true | Domain | ADGRF2P/ADGRF4-like, N-terminal domain | ADGRF2P/ADGRF4-like, N-terminal domain | ADGRF2P/ADGRF4-like_N | 3 |
IPR060342 | 60,342 | Lysyl endopeptidase, N-terminal domain | Lysyl_endopep_N | Domain | 518 | false | false | This entry represents the N-terminal domain of lysyl endopeptidase found in Pseudomonas species and related bacteria. This domain corresponds to the pro-peptide region (residues 25-211) of the lysyl endopeptidase precursor. The pro-peptide is removed by autocatalytic processing to generate the mature, active enzyme [ ]... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27052"
] | [
"Lysyl_endopep_N"
] | [
518
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162145"
] | [
"12419815"
] | [
"Identification of the active site residues of Pseudomonas aeruginosa protease IV. Importance of enzyme activity in autoprocessing and activation."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Trieres chinensis",
"ecological metagenomes"
] | [
513,
1,
4
] | 3 | [] | [] | 0 | true | Domain | Lysyl endopeptidase, N-terminal domain | Lysyl endopeptidase, N-terminal domain | Lysyl_endopep_N | 5 |
IPR060344 | 60,344 | Exo-beta-1,3-glucanase-like domain | LAM55-like_dom | Domain | 3,309 | false | false | This entry represents the second domain in LAM55 (Exo-beta-1,3-glucanase). This domain contains a right-handed β helix, similar to that first found in pectate lyase. Members of this entry are mainly found in bacteria. Exo-beta-1,3-glucanase (SACTE_4363, ) specifically hydrolyses laminarin and laminarioligosaccharides, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27525"
] | [
"LAM55_pectate-like"
] | [
3309
] | 1 | [] | [] | [] | 0 | [
"4pew",
"4pex",
"4pey",
"4pez",
"4pf0",
"4tyv",
"4tz1",
"4tz3",
"4tz5"
] | 9 | [
"PUB00157290",
"PUB00157291",
"PUB00158226"
] | [
"29954113",
"25752603",
"28625980"
] | [
"Isolation of β-1,3-Glucanase-Producing Microorganisms from <i>Poria cocos</i> Cultivation Soil via Molecular Biology.",
"Active site and laminarin binding in glycoside hydrolase family 55.",
"Functional Analysis of a Novel β-(1,3)-Glucanase from Corallococcus sp. Strain EGB Containing a Fascin-Like Module."
] | [
2018,
2015,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3029,
273,
7
] | 3 | [] | [] | 0 | true | Domain | Exo-beta-1,3-glucanase-like domain | Exo-beta-1,3-glucanase-like domain | LAM55-like_dom | 6 |
IPR060346 | 60,346 | ZNF142, C2H2-type zinc finger | Znf-C2H2_ZNF142 | Domain | 911 | false | false | This C2H2-type zinc finger is found in human Zinc finger protein 142 (ZNF142), which may be involved in transcriptional regulation. This entry is specific to vertebrates. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27528"
] | [
"Znf-C2H2_ZNF142"
] | [
911
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
911
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
4
] | 4 | true | Domain | ZNF142, C2H2-type zinc finger | ZNF142, C2H2-type zinc finger | Znf-C2H2_ZNF142 | 7 |
IPR060347 | 60,347 | AllF, heavy metal-associated domain | HMA_AllF_N | Domain | 2,990 | false | false | This heavy metal-associated (HMA) domain is found at the N-terminal end of Oxamate carbamoyltransferase subunit AllF from Escherichia coli, a component of a carbamoyltransferase involved in the anaerobic nitrogen utilisation via the assimilation of allantoin that catalyses the conversion of oxalurate (N-carbamoyl-2-oxo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27530"
] | [
"HMA_AllF_N"
] | [
2990
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155434",
"PUB00162022"
] | [
"38888336",
"34494882"
] | [
"Oxamic transcarbamylase of <i>Escherichia coli</i> is encoded by the three genes <i>allFGH</i> (formerly <i>fdrA, ylbE</i>, and <i>ylbF</i>).",
"An Escherichia coli FdrA Variant Derived from Syntrophic Coculture with a Methanogen Increases Succinate Production Due to Changes in Allantoin Degradation."
] | [
2024,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
17,
2913,
2,
58
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | AllF, heavy metal-associated domain | AllF, heavy metal-associated domain | HMA_AllF_N | 7 |
IPR060348 | 60,348 | Rv3395c/MT3502-like, N-terminal domain | Rv3395c/MT3502-like_N | Domain | 2,702 | false | false | This entry represents the N-terminal domain of the uncharacterised protein MT3502 and Uncharacterized protein Rv3395c from Mycobacterium tuberculosis and similar proteins mainly from actinomycetes. MT3502 has a P-loop containing nucleotide triphosphate hydrolase fold . This domain is also found in predicted recombinase... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27531"
] | [
"MT3502_N"
] | [
2702
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
2642,
60
] | 2 | [] | [] | 0 | true | Domain | Rv3395c/MT3502-like, N-terminal domain | Rv3395c/MT3502-like, N-terminal domain | Rv3395c/MT3502-like_N | 7 |
IPR060349 | 60,349 | Kizuna, N-terminal | Kizuna_N | Domain | 918 | false | false | This entry represents the N-terminal helical region of centrosomal protein kizuna. This N-terminal region contains a predicted coiled-coil domain and its specific function remains to be determined [ ]. Kizuna (is a Japanese word meaning "bond") is a centrosomal protein required for establishing a robust mitotic centros... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28416"
] | [
"Kizuna_N"
] | [
918
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061740"
] | [
"16980960"
] | [
"The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
918
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
9
] | 4 | true | Domain | Kizuna, N-terminal | Kizuna, N-terminal | Kizuna_N | 7 |
IPR060350 | 60,350 | SKA3, helical domain | SKA3_helical | Domain | 809 | false | false | This entry represents a helical region of SKA complex subunit 3, whose specific function remains to be determined. The SKA complex is an essential mitotic component required for accurate cell division in human cells. It is a microtubule plus end-binding complex of the outer kinetochore that stabilises spindle microtubu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28417"
] | [
"SKA3_helical"
] | [
809
] | 1 | [] | [] | [] | 0 | [
"4aj5"
] | 1 | [
"PUB00061772",
"PUB00077598",
"PUB00078502",
"PUB00078505"
] | [
"19289083",
"23085020",
"19646878",
"19360002"
] | [
"The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility.",
"The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.",
"Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis."... | [
2009,
2012,
2009,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
809
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
1,
3
] | 4 | true | Domain | SKA3, helical domain | SKA3, helical domain | SKA3_helical | 7 |
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