interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060351 | 60,351 | CapK, C-terminal domain | CapK_C | Domain | 1,998 | false | false | This entry represents the C-terminal domain of CapK,and similar prokaryotic proteins. CapK is required for the biosynthesis of type 1 capsular polysaccharide. This domain has an AMP-binding fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27533"
] | [
"CapK_C"
] | [
1998
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007578"
] | [
"7961465"
] | [
"Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Cladocopium goreaui",
"ecological metagenomes"
] | [
118,
1808,
1,
71
] | 4 | [] | [] | 0 | true | Domain | CapK, C-terminal domain | CapK, C-terminal domain | CapK_C | 9 |
IPR060352 | 60,352 | HTH-type transcriptional regulator MmpR5, helical hairpin | 2H_MmpR5 | Domain | 4,488 | false | false | This entry represents the C-terminal α-hairpin domain of HTH-type transcriptional regulator MmpR5 from Mycobacterium tuberculosis and related proteins. This domain is involved in dimerisation. MmpR5 (also known as Rv0678) controls the expression level of the MmpS2-MmpL2, MmpS4-MmpL4, and MmpS5-MmpL5 transport systems i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27059"
] | [
"HTH_MmpR5"
] | [
4488
] | 1 | [] | [] | [] | 0 | [
"4nb5"
] | 1 | [
"PUB00162027",
"PUB00162028",
"PUB00162029"
] | [
"24737322",
"18851927",
"24590481"
] | [
"Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.",
"Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system.",
"Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis."
] | [
2014,
2009,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Exaiptasia diaphana",
"Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)",
"ecological metagenomes"
] | [
4480,
1,
1,
6
] | 4 | [] | [] | 0 | true | Domain | HTH-type transcriptional regulator MmpR5, helical hairpin | HTH-type transcriptional regulator MmpR5, helical hairpin | 2H_MmpR5 | 1 |
IPR060353 | 60,353 | WetA, C-terminal | WetA_C | Domain | 1,125 | false | false | This entry represents the C-terminal helical region of WetA, a key transcriptional regulator involved in conidiation and spore maturation in filamentous fungi. WetA proteins contain an acidic N-terminal region, a serine/threonine/proline-rich middle domain, and a basic C-terminal region. This C-terminal region is essen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28419"
] | [
"WetA_C"
] | [
1125
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090538",
"PUB00090539",
"PUB00090540",
"PUB00090541",
"PUB00162389",
"PUB00162390",
"PUB00162391",
"PUB00162392",
"PUB00162393",
"PUB00162394"
] | [
"2655931",
"1986246",
"2180753",
"7704830",
"20966095",
"24123270",
"24186953",
"8078481",
"25530311",
"19850144"
] | [
"Interactions of three sequentially expressed genes control temporal and spatial specificity in Aspergillus development.",
"Aspergillus nidulans wetA activates spore-specific gene expression.",
"Conidium differentiation in Aspergillus nidulans wild-type and wet-white (wetA) mutant strains.",
"Cellular effects... | [
1989,
1991,
1990,
1994,
2011,
2013,
2014,
1994,
2015,
2010
] | 10 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
1125
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | WetA, C-terminal | WetA, C-terminal | WetA_C | 7 |
IPR060354 | 60,354 | Coiled-coil domain-containing protein 89 | CCDC89 | Family | 779 | false | false | Coiled-coil domain-containing protein 89 (CCDC89), also known as Bc8 orange-interacting protein (BOIP), interacts with the orange domain of HRT1. BOIP binds to the orange domain of HRT1/Hey1 and is predominantly expressed at a specific stage in spermatogenesis. BOIP may play a role in the maturation process from haploi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28422"
] | [
"CCDC89"
] | [
779
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094039"
] | [
"14648848"
] | [
"Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse."
] | [
2003
] | 1 | [
"IPR043450"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
779
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
4
] | 4 | true | Family | Coiled-coil domain-containing protein 89 | Coiled-coil domain-containing protein 89 | CCDC89 | 8 |
IPR060355 | 60,355 | Uncharacterized protein MJ0013-like domain | MJ0013-like_dom | Domain | 566 | false | false | This entry represents a domain that covers the whole sequence of MJ0013, an uncharacterised protein found in Methanocaldococcus jannaschii. The protein is 162 amino acids in length with a molecular weight of approximately 19.6 kDa. Its function remains to be determined. The protein is highly positively charged, but acc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27234"
] | [
"MJ0013"
] | [
566
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
555,
7,
4
] | 3 | [] | [] | 0 | true | Domain | Uncharacterized protein MJ0013-like domain | Uncharacterized protein MJ0013-like domain | MJ0013-like_dom | 7 |
IPR060357 | 60,357 | Epiregulin, C-terminal helix | Epiregulin_C | Domain | 889 | false | false | This entry represents the C-terminal helix of epiregulin. Epiregulin is a ligand of the epidermal growth factor receptor (EGFR) and ERBB4, and stimulates their tyrosine phosphorylation [ , ]. The mature epiregulin protein contains an EGF-like domain that is essential for receptor binding. Structural studies have shown ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28423"
] | [
"Epiregulin_C"
] | [
889
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1227986",
"R-HSA-1236394",
"R-HSA-1250196",
"R-HSA-1250342",
"R-HSA-1250347",
"R-HSA-1251985",
"R-HSA-1257604",
"R-HSA-177929",
"R-HSA-179812",
"R-HSA-180292",
"R-HSA-180336",
"R-HSA-182971",
"R-HSA-1963640",
"R-HSA-1963642",
"R-HSA-212718",
"R-HSA-2219530",
"R-HSA-5638303",
... | [
"REACTOME:R-HSA-1227986",
"REACTOME:R-HSA-1236394",
"REACTOME:R-HSA-1250196",
"REACTOME:R-HSA-1250342",
"REACTOME:R-HSA-1250347",
"REACTOME:R-HSA-1251985",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA-177929",
"REACTOME:R-HSA-179812",
"REACTOME:R-HSA-180292",
"REACTOME:R-HSA-180336",
"REACTOME:R-... | 72 | [] | 0 | [
"PUB00161938",
"PUB00161939"
] | [
"9990076",
"9419975"
] | [
"Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin.",
"Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4."
] | [
1999,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
19,
870
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3
] | 4 | true | Domain | Epiregulin, C-terminal helix | Epiregulin, C-terminal helix | Epiregulin_C | 8 |
IPR060358 | 60,358 | MazE/EndoAI antitoxin, C-terminal domain | MazE/EndoAI_antitoxin_C | Domain | 1,485 | false | false | This entry represents the C-terminal domain of MazE family antitoxins, which are components of type II toxin-antitoxin systems. This domain is distinct from the N-terminal ribbon-helix-helix (RHH) DNA-binding domain ( ) found in these proteins. In shorter MazE proteins from Staphylococcus species, this domain typically... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27083"
] | [
"MazE_antitoxin_C"
] | [
1485
] | 1 | [] | [] | [] | 0 | [
"4me7"
] | 1 | [
"PUB00147741",
"PUB00162148",
"PUB00162149"
] | [
"24120662",
"15882409",
"21763692"
] | [
"Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis.",
"The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.",
"Bacillus subtilis MazF-bs (EndoA) is a UACAU-specific mRNA interferase."
] | [
2013,
2005,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Bacillus phage FADO",
"unclassified sequences"
] | [
1479,
1,
5
] | 3 | [] | [] | 0 | true | Domain | MazE/EndoAI antitoxin, C-terminal domain | MazE/EndoAI antitoxin, C-terminal domain | MazE/EndoAI_antitoxin_C | 4 |
IPR060360 | 60,360 | ECM13-like, helical domain | ECM13-like_helical | Domain | 1,539 | false | false | This entry represents a helical domain found in Protein ECM13 and the uncharacterised protein YJR115W from Saccharomyces cerevisiae and similar fungal proteins. ECM13 may be involved in cell wall organisation and biogenesis. The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27894"
] | [
"YJR115W_helical"
] | [
1539
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1539
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Domain | ECM13-like, helical domain | ECM13-like, helical domain | ECM13-like_helical | 9 |
IPR060361 | 60,361 | Bud site selection protein RAX1, C-terminal domain | RAX1_C | Domain | 1,515 | false | false | This entry represents the C-terminal helical domain of RAX1 proteins found in fungi. RAX1 is a bud site selection protein involved in cell polarisation and division [ , , ]. The protein contains an N-terminal RGS domain and this C-terminal helical region that spans transmembrane helices. RAX1 localises to the cell memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27892"
] | [
"RAX1_C"
] | [
1515
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-983231",
"R-SPO-983231"
] | [
"REACTOME:R-SCE-983231",
"REACTOME:R-SPO-983231"
] | 2 | [] | 0 | [
"PUB00162271",
"PUB00162504",
"PUB00162505"
] | [
"14980713",
"20678480",
"32152126"
] | [
"Rax1, a protein required for the establishment of the bipolar budding pattern in yeast.",
"Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells.",
"Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient... | [
2004,
2010,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1515
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Bud site selection protein RAX1, C-terminal domain | Bud site selection protein RAX1, C-terminal domain | RAX1_C | 4 |
IPR060362 | 60,362 | Geminin coiled-coil domain-containing protein 1/Multicilin, C-terminal domain | GMNC/MCIDAS_C | Domain | 1,352 | false | false | This entry represents the C-terminal β-sheet domain of human geminin coiled-coil domain-containing protein 1 (GEMC1, also known as GMNC), Multicilin (MCIDAS) and similar proteins from vertebrates. The specific function of this domain remains to be determined. GEMC1 is a regulator of DNA replication that promotes initia... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27888"
] | [
"GMNC_C"
] | [
1352
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00059235",
"PUB00070657",
"PUB00070887",
"PUB00145514",
"PUB00150622",
"PUB00161984"
] | [
"22231168",
"20383140",
"24064211",
"21543332",
"25048963",
"24934224"
] | [
"Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.",
"GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.",
"The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing... | [
2012,
2010,
2013,
2011,
2014,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1352
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2,
7
] | 4 | true | Domain | Geminin coiled-coil domain-containing protein 1/Multicilin, C-terminal domain | Geminin coiled-coil domain-containing protein 1/Multicilin, C-terminal domain | GMNC/MCIDAS_C | 6 |
IPR060363 | 60,363 | TNFAIP3-interacting protein 1, N-terminal domain | TNIP1_N | Domain | 1,493 | false | false | This entry represents the N-terminal helical domain of TNFAIP3- interacting protein 1 (TNIP1) and similar proteins from vertebrates. This domain forms a coiled-coil structure spanning approximately residues 20-73 in the human protein. The specific function of this domain remains to be determined. TNIP1 inhibits NF-kapp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27887"
] | [
"TNIP1_N"
] | [
1493
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5689896",
"R-MMU-5689896"
] | [
"REACTOME:R-HSA-5689896",
"REACTOME:R-MMU-5689896"
] | 2 | [] | 0 | [
"PUB00078558",
"PUB00162337",
"PUB00162338"
] | [
"16684768",
"21885437",
"9923610"
] | [
"ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.",
"ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.",
"Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression."
] | [
2006,
2011,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1493
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
11,
7,
6
] | 4 | true | Domain | TNFAIP3-interacting protein 1, N-terminal domain | TNFAIP3-interacting protein 1, N-terminal domain | TNIP1_N | 6 |
IPR060364 | 60,364 | NuzM, N-terminal domain | NuzM_N | Domain | 1,518 | false | false | This entry represents the N-terminal domain of the fungal-specific NuzM subunit (also known as NUO2) of the mitochondrial membrane respiratory chain NADH-ubiquinone oxidoreductase (Complex I). This domain comprises a short helix with loops at the N-terminal region of the protein. The specific function of this domain re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27885"
] | [
"NuzM_N"
] | [
1518
] | 1 | [] | [] | [] | 0 | [
"6rfq",
"6rfr",
"6rfs",
"6y79",
"6yj4",
"7b0n",
"7o6y",
"7o71",
"7zm7",
"7zmb",
"7zmg",
"9iho",
"9ihp",
"9ihq",
"9ihr"
] | 15 | [
"PUB00148801",
"PUB00153146"
] | [
"25801605",
"26087349"
] | [
"Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis.",
"Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction."
] | [
2015,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1518
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | NuzM, N-terminal domain | NuzM, N-terminal domain | NuzM_N | 2 |
IPR060365 | 60,365 | NuzM, C-terminal domain | NuzM_C | Domain | 1,065 | false | false | This entry represents the C-terminal domain of the fungal-specific NuzM subunit (also known as NUO2) of the mitochondrial membrane respiratory chain NADH-ubiquinone oxidoreductase (Complex I). This domain comprises a short helices with loops at the C-terminal region of the protein. The specific function of this domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27886"
] | [
"NuzM_C"
] | [
1065
] | 1 | [] | [] | [] | 0 | [
"6rfq",
"6rfr",
"6rfs",
"6y79",
"6yj4",
"7b0n",
"7o6y",
"7o71",
"7zm7",
"7zmb",
"7zmg",
"9iho",
"9ihp",
"9ihq",
"9ihr"
] | 15 | [
"PUB00084325",
"PUB00148801",
"PUB00153146"
] | [
"2137337",
"25801605",
"26087349"
] | [
"Primary structure, in vitro expression and import into mitochondria of a 29/21-kDa subunit of complex I from Neurospora crassa.",
"Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis.",
"Candida albicans cell shaving uncovers new p... | [
1990,
2015,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1065
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | NuzM, C-terminal domain | NuzM, C-terminal domain | NuzM_C | 4 |
IPR060366 | 60,366 | Precursor of CEP13/IDA-like | PCP13/IDA-like | Family | 2,070 | false | false | This entry represents a group of from plant proteins, including IDA-like peptides and Precursor of CEP13 (PCP13). IDA contains a β sheet connected to a helix and functions as a secreted signalling peptide involved in floral organ abscission [ , , ]. It promotes abscission zone cell rounding and acts through receptor-li... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27884"
] | [
"IDL5"
] | [
2070
] | 1 | [] | [] | [] | 0 | [
"5ixt"
] | 1 | [
"PUB00162053",
"PUB00162054",
"PUB00162055"
] | [
"12972671",
"18660431",
"27058169"
] | [
"Inflorescence deficient in abscission controls floral organ abscission in Arabidopsis and identifies a novel family of putative ligands in plants.",
"The EPIP peptide of INFLORESCENCE DEFICIENT IN ABSCISSION is sufficient to induce abscission in arabidopsis through the receptor-like kinases HAESA and HAESA-LIKE2... | [
2003,
2008,
2016
] | 3 | [] | [
"IPR038930",
"IPR039639"
] | 0 | 2 | 0 | [
"Euphyllophyta"
] | [
2070
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
5,
8
] | 3 | true | Family | Precursor of CEP13/IDA-like | Precursor of CEP13/IDA-like | PCP13/IDA-like | 3 |
IPR060367 | 60,367 | Proton pump-interactor, C-terminal region | PPI_C | Domain | 1,560 | false | false | This entry represents the C-terminal transmembrane region of proton pump-interactor (PPI) proteins found in plant species. These proteins may regulate plasma membrane ATPase activity [ ]. PPI1 has been shown to promote AHA1 plasma membrane ATPase activity by binding to a site different from the 14-3-3 binding site [ , ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27883"
] | [
"PPI_C"
] | [
1560
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070626",
"PUB00155293"
] | [
"16279950",
"12182706"
] | [
"Characterization of the interaction between the plasma membrane H-ATPase of Arabidopsis thaliana and a novel interactor (PPI1).",
"A novel interaction partner for the C-terminus of Arabidopsis thaliana plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on H+-ATPase activity differ from those ... | [
2005,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1560
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
7,
20
] | 3 | true | Domain | Proton pump-interactor, C-terminal region | Proton pump-interactor, C-terminal region | PPI_C | 5 |
IPR060369 | 60,369 | Pre-rRNA-processing protein ESF2-like coiled-coil region | ESF2-like_CC | Domain | 3,683 | false | false | This entry represents a coiled-coil in pre-rRNA- processing protein ESF2 (18S rRNA factor 2) and similar eukaryotic proteins. This domain follows the central RRM domain and is involved in protein-protein interactions during ribosome biogenesis. ESF2 belongs to the ESF2/ABP1 family and is involved in small subunit proce... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27577"
] | [
"ESF2_C"
] | [
3683
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083328",
"PUB00083329",
"PUB00161943"
] | [
"15964808",
"16772403",
"15123810"
] | [
"Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.",
"The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis.",
"The diploid genome sequence of Candida albicans."
] | [
2005,
2006,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3683
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
2,
1,
1,
1,
2,
2,
1,
1,
3
] | 12 | true | Domain | Pre-rRNA-processing protein ESF2-like coiled-coil region | Pre-rRNA-processing protein ESF2-like coiled-coil region | ESF2-like_CC | 6 |
IPR060371 | 60,371 | TAM12 | TAM12 | Family | 1,200 | false | false | This entry represents the TAM12 family of small proteins found in fungi. TAM12 (Transcripts altered in meiosis protein 12) is a 66-amino acid protein from Schizosaccharomyces pombe that is differentially expressed during meiosis [ ]. The protein contains a disordered N-terminal region and low-complexity sequences. Memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28428"
] | [
"TAM12"
] | [
1200
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00148970"
] | [
"21270388"
] | [
"Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1200
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
1,
3
] | 4 | true | Family | TAM12 | TAM12 | TAM12 | 2 |
IPR060373 | 60,373 | Let-653, immunoglobulin-like domain | Ig_Let-653 | Domain | 961 | false | false | This immunoglobulin-like (Ig-like) domain is found in Protein let-653 from Caenorhabditis elegans and similar sequences from nematodes and arthropods. Let-653 is required for epithelial tube development and shaping and involved in the morphogenesis and function of the three unicellular tubes of the excretory system, th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28434"
] | [
"Ig_Let-653"
] | [
961
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162090",
"PUB00162091",
"PUB00162092"
] | [
"7476875",
"27482894",
"33141826"
] | [
"Characterization of the let-653 gene in Caenorhabditis elegans.",
"Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix.",
"A C. elegans Zona Pellucida domain protein functions via its ZPc domain."
] | [
1995,
2016,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
961
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
7,
2
] | 2 | true | Domain | Let-653, immunoglobulin-like domain | Let-653, immunoglobulin-like domain | Ig_Let-653 | 3 |
IPR060374 | 60,374 | RelA/SpoT, RIS domain | RelA_RIS | Domain | 31,713 | false | false | This entry represents the Ribosome-InterSubunit (RIS) domains found in RelA/SpoT proteins, adjacent to the ACT domain [ , ]. The RIS domain is part of the binding interface between the C-terminal region and the ribosome, bridging the large and the small ribosomal subunits. RIS contains a four-stranded β-sheet and a sho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28438"
] | [
"RelA_RIS"
] | [
31713
] | 1 | [
"EC"
] | [
"2.7.6.5"
] | [
"EC:2.7.6.5"
] | 1 | [
"5iqr",
"5kps",
"5kpv",
"5kpw",
"5kpx",
"5l3p",
"6htq",
"7qpr",
"8fr8"
] | 9 | [
"PUB00059269",
"PUB00095792",
"PUB00098872"
] | [
"15866041",
"27434674",
"32937119"
] | [
"ppGpp: a global regulator in Escherichia coli.",
"Ribosome•RelA structures reveal the mechanism of stringent response activation.",
"Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel."
] | [
2005,
2016,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
30991,
14,
90,
3,
615
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | RelA/SpoT, RIS domain | RelA/SpoT, RIS domain | RelA_RIS | 2 |
IPR060375 | 60,375 | CCDC27/FHAD1, coiled-coil | CCDC27/FHAD1_CC | Domain | 1,418 | false | false | This entry represents the coiled-coil region of coiled-coil domain-containing protein 27 (CCDC27) and Forkhead-associated domain-containing protein 1 (FHAD1). CCDC27 contains a single coiled-coil region located in the central portion of the sequence. CCDC27 is widely conserved across mammalian species and shows enriche... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28447"
] | [
"Ccdc27"
] | [
1418
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162506"
] | [
"38563001"
] | [
"Forkhead-associated phosphopeptide binding domain 1 (FHAD1) deficiency impaired murine sperm motility."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1418
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
8
] | 3 | true | Domain | CCDC27/FHAD1, coiled-coil | CCDC27/FHAD1, coiled-coil | CCDC27/FHAD1_CC | 7 |
IPR060376 | 60,376 | Antitoxin RelB2-4-like, C-terminal domain | RelB2-4-like_C | Domain | 1,473 | false | false | This entry represents the C-terminal in antitoxin RelB2, RelB3, RelB4 and Orphan antitoxin ParD2 proteins, mostly found in bacteria. RelB2-4 and ParD2 are antitoxin components of a type II toxin-antitoxin (TA) system. They neutralise the effect of the cognate toxin RelE2-4 respectively, but not other RelE or ParE toxin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27535"
] | [
"RelB3_C"
] | [
1473
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056596",
"PUB00068089"
] | [
"15718296",
"20487277"
] | [
"Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.",
"Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1433,
2,
38
] | 3 | [] | [] | 0 | true | Domain | Antitoxin RelB2-4-like, C-terminal domain | Antitoxin RelB2-4-like, C-terminal domain | RelB2-4-like_C | 7 |
IPR060377 | 60,377 | PRAME-like, C-terminal LRR domain | PRAME_C | Domain | 4,708 | false | false | This entry represents the leucine-rich domain at the C-terminal in PRAME and similar proteins including LCR14 and OOG3 mainly from animals. PRAME proteins are involved in various cellular processes, primarily through its role as a substrate-recognition component of Cul2-RING E3 ubiquitin-protein ligase complexes. These... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27089"
] | [
"PRAME_C"
] | [
4708
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9758274",
"R-HSA-9758274",
"R-MMU-9758274",
"R-RNO-9758274"
] | [
"REACTOME:R-BTA-9758274",
"REACTOME:R-HSA-9758274",
"REACTOME:R-MMU-9758274",
"REACTOME:R-RNO-9758274"
] | 4 | [] | 0 | [
"PUB00033472",
"PUB00060342",
"PUB00081455",
"PUB00155309",
"PUB00162261",
"PUB00162262",
"PUB00162263",
"PUB00162264",
"PUB00162265"
] | [
"16580637",
"16179254",
"23565261",
"26138980",
"28604677",
"29731491",
"21822215",
"27426725",
"21425410"
] | [
"Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.",
"The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.",
"Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.",
"SEL... | [
2006,
2005,
2013,
2015,
2017,
2018,
2011,
2016,
2011
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"bird metagenome"
] | [
4705,
2,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
44,
126,
66
] | 4 | true | Domain | PRAME-like, C-terminal LRR domain | PRAME-like, C-terminal LRR domain | PRAME_C | 7 |
IPR060378 | 60,378 | PRAME-like, N-terminal domain | PRAME_N | Domain | 3,789 | false | false | This entry represents the N-terminal domain in PRAME and similar proteins including LCR14 and OOG3 mainly from animals. PRAME proteins are involved in various cellular processes, primarily through its role as a substrate-recognition component of Cul2-RING E3 ubiquitin-protein ligase complexes. These complexes mediate t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27091"
] | [
"PRAME_N"
] | [
3789
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9758274",
"R-HSA-9758274",
"R-MMU-9758274",
"R-RNO-9758274"
] | [
"REACTOME:R-BTA-9758274",
"REACTOME:R-HSA-9758274",
"REACTOME:R-MMU-9758274",
"REACTOME:R-RNO-9758274"
] | 4 | [] | 0 | [
"PUB00033472",
"PUB00060342",
"PUB00081455",
"PUB00155309",
"PUB00162261",
"PUB00162262",
"PUB00162263",
"PUB00162264",
"PUB00162265"
] | [
"16580637",
"16179254",
"23565261",
"26138980",
"28604677",
"29731491",
"21822215",
"27426725",
"21425410"
] | [
"Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.",
"The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.",
"Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.",
"SEL... | [
2006,
2005,
2013,
2015,
2017,
2018,
2011,
2016,
2011
] | 9 | [] | [] | 0 | 0 | null | [
"Geothrix oryzae",
"Opisthokonta"
] | [
1,
3788
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
52,
131,
62
] | 4 | true | Domain | PRAME-like, N-terminal domain | PRAME-like, N-terminal domain | PRAME_N | 1 |
IPR060379 | 60,379 | NosR/NirI-like, C-terminal domain | NosR/NirI-like_C | Domain | 2,098 | false | false | This entry represents the C-terminal domain in Regulatory protein NosR and Protein NirI, found in bacteria. NosR is a transcriptional activator of the nitrous-oxide reductase gene NosZ [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27538"
] | [
"NosR"
] | [
2098
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001426"
] | [
"1324835"
] | [
"Derived amino acid sequences of the nosZ gene (respiratory N2O reductase) from Alcaligenes eutrophus, Pseudomonas aeruginosa and Pseudomonas stutzeri reveal potential copper-binding residues. Implications for the CuA site of N2O reductase and cytochrome-c oxidase."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
2052,
2,
9,
35
] | 4 | [] | [] | 0 | true | Domain | NosR/NirI-like, C-terminal domain | NosR/NirI-like, C-terminal domain | NosR/NirI-like_C | 7 |
IPR060380 | 60,380 | Conjugation-associated, 9-bladed beta-propeller domain | Conj_beta_prop_9 | Domain | 163 | false | false | This entry represents a domain which is predicted to fold into a nine-bladed distorted β-propeller and found in proteins involved in bacterial DNA conjugation. In this conjugation system, the 9-bladed architecture likely provides multiple binding surfaces for interactions with other conjugation machinery components or ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27095"
] | [
"Conj_beta_prop_9"
] | [
163
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782"
] | [
"18554329"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
163
] | 1 | [] | [] | 0 | true | Domain | Conjugation-associated, 9-bladed beta-propeller domain | Conjugation-associated, 9-bladed beta-propeller domain | Conj_beta_prop_9 | 1 |
IPR060382 | 60,382 | ATRAID, C-terminal region | ATRAID_C | Domain | 747 | false | false | This entry represents the C-terminal helix of ATRAID (all-trans retinoic acid-induced differentiation factor) found in vertebrates. This entry represents the transmembrane region and cytoplasmic tail of the protein. ATRAID (All-trans retinoic acid-induced differentiation factor), also known as APR3, is a membrane prote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28451"
] | [
"ATRAID_C"
] | [
747
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092891",
"PUB00092892",
"PUB00161813"
] | [
"21723284",
"17524364",
"29745899"
] | [
"NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation.",
"Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.",
"Identification of a transporter complex responsible for the cytosolic entry ... | [
2011,
2007,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
747
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
5
] | 4 | true | Domain | ATRAID, C-terminal region | ATRAID, C-terminal region | ATRAID_C | 4 |
IPR060383 | 60,383 | BIVM | BIVM | Family | 788 | false | false | This entry represents the BIVM (basic immunoglobulin-like variable motif-containing protein) family of proteins found in vertebrates. These proteins are approximately 500 amino acids in length and localise to both cytoplasm and nucleus [ ]. BIVM proteins are widely expressed across tissues, with higher levels in spleen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28452"
] | [
"BIVM"
] | [
788
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088450"
] | [
"12036287"
] | [
"BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
788
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
1,
3
] | 3 | true | Family | BIVM | BIVM | BIVM | 9 |
IPR060385 | 60,385 | UvrC/Cho excinuclease, middle domain | UvrC_M | Domain | 33,669 | false | false | This entry represents a domain found in UvrC and Cho excinucleases involved in nucleotide excision repair. This domain is positioned between the N-terminal GIY-YIG endonuclease domain ( ) and the UVR domain ( ), typically spanning approximately residues 95-200 in UvrC proteins and 115-210 in Cho proteins. In the multi-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27096"
] | [
"UvrC_M"
] | [
33669
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00102495"
] | [
"11818552"
] | [
"Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
603,
32328,
83,
655
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | UvrC/Cho excinuclease, middle domain | UvrC/Cho excinuclease, middle domain | UvrC_M | 5 |
IPR060386 | 60,386 | Sip5 domain | SIP5_dom | Domain | 1,576 | false | false | This entry represents a domain found towards the N-terminal in fungal Sip5 proteins. Sip5 plays a role in the regulation of SNF1 kinase. It may negatively regulate SNF1 kinase under glucose-limiting conditions, by promoting the interaction of the REG1/GLC7 phosphatase complex with the kinase. It interacts directly with... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd24139"
] | [
"SIP5-like"
] | [
1576
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089417",
"PUB00158801",
"PUB00158802"
] | [
"10628972",
"29249654",
"29322248"
] | [
"Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae.",
"The Std1 Activator of the Snf1/AMPK Kinase Controls Glucose Response in Yeast by a Regulated Protein Aggregation.",
"A reversible liquid drop aggregation controls glucose response in yeast."
] | [
2000,
2017,
2018
] | 3 | [
"IPR060384"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1576
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Sip5 domain | Sip5 domain | SIP5_dom | 2 |
IPR060387 | 60,387 | Type IV secretion system ATPase VirB4/TrbE, N-terminal | VirB4_TrbE_N | Domain | 7,706 | false | false | This entry represents the N-terminal domain of VirB4 and TrbE proteins, which are components of type IV secretion systems. The domain is found at the N-terminal of VirB4/TrbE proteins, which range from approximately 150 residues to over 800 residues in the full-length proteins. In the complete proteins, this N-terminal... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27097"
] | [
"VirB4_TrbE_N"
] | [
7706
] | 1 | [] | [] | [] | 0 | [
"7o41",
"7o42",
"7o43",
"7oiu",
"8rtb",
"8rtd"
] | 6 | [
"PUB00007538",
"PUB00007539",
"PUB00060318",
"PUB00060322",
"PUB00060323",
"PUB00060325",
"PUB00076811",
"PUB00097878",
"PUB00097879",
"PUB00162383",
"PUB00163229",
"PUB00163230"
] | [
"11104802",
"11447179",
"10940027",
"8464913",
"10518754",
"15322034",
"22745169",
"31088930",
"26565397",
"9916087",
"34424036",
"21118511"
] | [
"Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil.",
"Epithelial intestinal cell apoptosis induced by Helicobacter pylori depends on expression of the cag pathogenicity island phenotype.",
"A homologue of an operon required for DNA transfer in Agrobacterium is requir... | [
2000,
2001,
2000,
1993,
1999,
2004,
2012,
2019,
2015,
1999,
2021,
2010
] | 12 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes",
"plasmids",
"uncultured Caudovirales phage"
] | [
7625,
28,
41,
11,
1
] | 5 | [] | [] | 0 | true | Domain | Type IV secretion system ATPase VirB4/TrbE, N-terminal | Type IV secretion system ATPase VirB4/TrbE, N-terminal | VirB4_TrbE_N | 4 |
IPR060388 | 60,388 | Rv1733c-like, central domain | Rv1733c-like | Domain | 4,091 | false | false | This entry represents the central region of the Rv1733c family of membrane proteins from Mycobacterium tuberculosis and related species. These proteins are approximately 210 amino acids in length and contain two predicted transmembrane helices, one near the N terminus and one near the C terminus. Rv1733c is a member of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27099"
] | [
"Rv1733c"
] | [
4091
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"freshwater metagenome"
] | [
4089,
2
] | 2 | [] | [] | 0 | true | Domain | Rv1733c-like, central domain | Rv1733c-like, central domain | Rv1733c-like | 2 |
IPR060389 | 60,389 | Meteorin-like, N-terminal domain | Meteorin-like_N | Domain | 2,596 | false | false | This entry represents the N-terminal domain of human meteorin (METRN), meteorin-like protein (METRNL, also known as subfatin) and similar animal sequences. This domain is located between the signal peptide and the main structural domain. METRN is involved in both glial cell differentiation and axonal network formation ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27640"
] | [
"Meteorin_N"
] | [
2596
] | 1 | [] | [] | [] | 0 | [
"7tl6"
] | 1 | [
"PUB00056622",
"PUB00089322"
] | [
"15085178",
"24906147"
] | [
"Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension.",
"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis."
] | [
2004,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2596
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
5,
10
] | 4 | true | Domain | Meteorin-like, N-terminal domain | Meteorin-like, N-terminal domain | Meteorin-like_N | 7 |
IPR060390 | 60,390 | ArfC-like, C-terminal domain | ArfC-like_C | Domain | 3,910 | false | false | This entry represents the C-terminal domain in uncharacterised membrane protein ArfC and related bacterial proteins. This protein is required for ammonia secretion and is also required for wild-type expression of ArfA [ , ]. This entry also represents the C-terminal in Uncharacterized membrane protein YttA, Small ribos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27542"
] | [
"ArfC"
] | [
3910
] | 1 | [] | [] | [] | 0 | [
"8crx",
"8cvm",
"9c4g"
] | 3 | [
"PUB00161803",
"PUB00161804"
] | [
"19168955",
"21410778"
] | [
"Rv0901 from Mycobacterium tuberculosis, a possible novel virulent gene proved through the recombinant Mycobacterium smegmatis.",
"Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments."
] | [
2009,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Viridiplantae",
"metagenomes"
] | [
3876,
2,
11,
21
] | 4 | [] | [] | 0 | true | Domain | ArfC-like, C-terminal domain | ArfC-like, C-terminal domain | ArfC-like_C | 2 |
IPR060391 | 60,391 | D-cycloserine synthetase DcsG, N-terminal PreATP-grasp domain | DcsG_N | Domain | 3,594 | false | false | This entry represents the N-terminal PreATP-grasp domain of DcsG, a D-cycloserine synthetase from Streptomyces lavendulae. This domain spans approximately 80 residues and precedes the C-terminal ATP-grasp domain. Mutagenesis studies suggest that the N-terminal domain is essential for enzyme activity, probably in substr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27100"
] | [
"DcsG_N"
] | [
3594
] | 1 | [] | [] | [] | 0 | [
"6jil"
] | 1 | [
"PUB00098976",
"PUB00161899"
] | [
"20086163",
"31793174"
] | [
"Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.",
"Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for d-cycloserine biosynthesis."
] | [
2010,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
3412,
68,
42,
72
] | 4 | [] | [] | 0 | true | Domain | D-cycloserine synthetase DcsG, N-terminal PreATP-grasp domain | D-cycloserine synthetase DcsG, N-terminal PreATP-grasp domain | DcsG_N | 6 |
IPR060392 | 60,392 | PABIR, helical domain | PABIR_helical | Domain | 2,700 | false | false | This entry represents the helical domain of the PABIR (formerly FAM122) animal proteins. In humans, this group includes PABIR1, PABIR2, and PABIR3 (also known as FAM122A, FAM122B, and FAM122C respectively). PABIR1 functions as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity [ , , ]. PABIR3 has b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27638"
] | [
"PABIR_N"
] | [
2700
] | 1 | [] | [] | [] | 0 | [
"8so0",
"8twe",
"8twi"
] | 3 | [
"PUB00096699",
"PUB00096700",
"PUB00162507"
] | [
"27588481",
"33108758",
"38123684"
] | [
"FAM122A, a new endogenous inhibitor of protein phosphatase 2A.",
"CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.",
"Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19."
] | [
2016,
2020,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2700
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
1,
13,
5,
8
] | 6 | true | Domain | PABIR, helical domain | PABIR, helical domain | PABIR_helical | 4 |
IPR060394 | 60,394 | CsoS1D-like, N-terminal domain | CsoS1D-like_N | Domain | 935 | false | false | This entry represents the N-terminal of carboxysome shell protein CsoS1D and similar proteins from bacteria, including Bacterial microcompartment protein trimer-2 (BMC-T2), Bacterial microcompartment protein trimer-3 (BMC-T3) and Carboxysome shell protein CcmP. This domain has a BMC (bacterial microcompartment) fold ( ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27545"
] | [
"CsoS1D_N"
] | [
935
] | 1 | [] | [] | [] | 0 | [
"3f56",
"3fch",
"4ht5",
"4ht7",
"5l39",
"5lsr",
"5lt5",
"5suh",
"5v74",
"5v75",
"5v76",
"6mzu",
"6mzv",
"6mzx",
"6mzy",
"6n07",
"6n09",
"6n0f",
"6n0g",
"7dhq"
] | 20 | [
"PUB00097925",
"PUB00161893",
"PUB00161894",
"PUB00161895",
"PUB00161896"
] | [
"30833088",
"28642439",
"23572529",
"28369612",
"22184212"
] | [
"The Plasticity of Molecular Interactions Governs Bacterial Microcompartment Shell Assembly.",
"Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell.",
"The structure of CcmP, a tandem bacterial microcompartment domain protein from the β-carboxysome, forms a subcompartment within a mi... | [
2019,
2017,
2013,
2017,
2012
] | 5 | [
"IPR044870"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Paulinella",
"ecological metagenomes"
] | [
904,
4,
27
] | 3 | [] | [] | 0 | true | Domain | CsoS1D-like, N-terminal domain | CsoS1D-like, N-terminal domain | CsoS1D-like_N | 9 |
IPR060395 | 60,395 | Metal-independent carbonic anhydrase domain | MICAH_dom | Domain | 1,071 | false | false | This entry represents a domain that covers most of the sequence in metal-independent carbonic anhydrase (MICAH) and similar bacterial sequences. This protein catalyses the hydration of carbon dioxide (CO2) to bicarbonate (HCO3-). It has only very low bicarbonate dehydration activity and may function even in metal-poor ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27546"
] | [
"MICAH"
] | [
1071
] | 1 | [] | [] | [] | 0 | [
"7c5v",
"7c5w",
"7c5x",
"7c5y"
] | 4 | [
"PUB00151529"
] | [
"34006275"
] | [
"Characterization of a novel type of carbonic anhydrase that acts without metal cofactors."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
666,
391,
14
] | 3 | [] | [] | 0 | true | Domain | Metal-independent carbonic anhydrase domain | Metal-independent carbonic anhydrase domain | MICAH_dom | 7 |
IPR060396 | 60,396 | Nod factor export ATP-binding protein I, C-terminal domain | NodI_C | Domain | 2,817 | false | false | This entry represents the C-terminal domain of NodI (Nod factor export ATP-binding protein I) proteins, which are ATP-binding components of ABC transporter complexes involved in the export of nodulation factors (Nod factors). This domain is found C-terminal to the ABC transporter domain ( ). Nodulation ABC transporter,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27102"
] | [
"NodI_C"
] | [
2817
] | 1 | [
"EC"
] | [
"7.6.2.-"
] | [
"EC:7.6.2.-"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Metazoa",
"unclassified sequences"
] | [
68,
2642,
4,
103
] | 4 | [] | [] | 0 | true | Domain | Nod factor export ATP-binding protein I, C-terminal domain | Nod factor export ATP-binding protein I, C-terminal domain | NodI_C | 8 |
IPR060397 | 60,397 | MNM1/HMG9-like, small beta-sheet domain | MNM1/HMG9-like_beta | Domain | 3,603 | false | false | This entry represents a small β-sheet domain found in metabolic network modulator 1 (MNM1) and High mobility group B protein 9 (HMG9) from Arabidopsis thaliana and similar plant sequences. MNM1 is a lineage-specific modulator of primary metabolism [ ]. The protein is approximately 286 amino acids in length and contains... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27637"
] | [
"MNM1_beta"
] | [
3603
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078265",
"PUB00098508",
"PUB00099190"
] | [
"16698901",
"19053246",
"25202318"
] | [
"NUCLEAR FUSION DEFECTIVE1 encodes the Arabidopsis RPL21M protein and is required for karyogamy during female gametophyte development and fertilization.",
"A novel family of plant DNA-binding proteins containing both HMG-box and AT-rich interaction domains.",
"The AT-hook motif-encoding gene METABOLIC NETWORK M... | [
2006,
2008,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
3603
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
33,
6,
14
] | 3 | true | Domain | MNM1/HMG9-like, small beta-sheet domain | MNM1/HMG9-like, small beta-sheet domain | MNM1/HMG9-like_beta | 3 |
IPR060399 | 60,399 | RNA exonuclease 3, N-terminal domain | REXO3_N | Domain | 1,006 | false | false | This entry represents the N-terminal domain of RNA exonuclease 3 (REXO3) from Aspergillus fumigatus, Emericella nidulans and close homologues from fungi. REXO3 is a 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and U5L snRNA. The protein contains a C-terminal exonuclease domain that carries ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28365"
] | [
"REXO3_N"
] | [
1006
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162276"
] | [
"33877360"
] | [
"A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1006
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | RNA exonuclease 3, N-terminal domain | RNA exonuclease 3, N-terminal domain | REXO3_N | 4 |
IPR060400 | 60,400 | Dynein regulatory complex subunit 11-like, N-terminal | DRC11_N | Domain | 2,515 | false | false | This domain is found at the N-terminal of human Dynein regulatory complex subunit 11 (DRC11), a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27107"
] | [
"DRC11_N"
] | [
2515
] | 1 | [] | [] | [] | 0 | [
"8glv",
"8j07",
"8th8",
"8tid",
"9e5c",
"9fqr"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2515
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
4,
5,
5,
6
] | 5 | true | Domain | Dynein regulatory complex subunit 11-like, N-terminal | Dynein regulatory complex subunit 11-like, N-terminal | DRC11_N | 4 |
IPR060402 | 60,402 | Guanine nucleotide exchange protein SMCR8, C-terminal | SMCR8_C | Domain | 1,439 | false | false | This domain is found at the C-terminal of human Guanine nucleotide exchange protein SMCR8, a component of the C9orf72-SMCR8 complex, which regulates autophagy and mTORC1 signalling [ , , , , , ]. This domain is predicted to show an α-β configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27109"
] | [
"SMCR8_C"
] | [
1439
] | 1 | [] | [] | [] | 0 | [
"6lt0",
"6v4u",
"7mge",
"7o2w"
] | 4 | [
"PUB00066993",
"PUB00085172",
"PUB00085173",
"PUB00085174",
"PUB00090522",
"PUB00091064",
"PUB00100251"
] | [
"20562859",
"28195531",
"27193190",
"27103069",
"27617292",
"27559131",
"32303654"
] | [
"Network organization of the human autophagy system.",
"Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.",
"The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.",
"Loss of C9ORF... | [
2010,
2017,
2016,
2016,
2016,
2016,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
1438,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
1,
1
] | 5 | true | Domain | Guanine nucleotide exchange protein SMCR8, C-terminal | Guanine nucleotide exchange protein SMCR8, C-terminal | SMCR8_C | 5 |
IPR060403 | 60,403 | APC1, N-terminal domain, nematodes | APC1_N_nem | Domain | 27 | false | false | This entry represents the N-terminal domain of anaphase-promoting complex subunit 1 proteins (APC1) found in nematodes. This domain adopts a lipocalin-like fold consisting of a β-barrel. This domain forms part of the multi-domain architecture of APC1. The specific function of this domain remains to be determined. In C.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27563"
] | [
"APC1_N"
] | [
27
] | 1 | [
"REACTOME"
] | [
"R-CEL-983168"
] | [
"REACTOME:R-CEL-983168"
] | 1 | [] | 0 | [
"PUB00055977",
"PUB00057287",
"PUB00057288",
"PUB00091489",
"PUB00098994",
"PUB00161792",
"PUB00161793",
"PUB00161794",
"PUB00161795",
"PUB00161796"
] | [
"16896351",
"11179667",
"17942546",
"26083744",
"27601667",
"11861581",
"11134076",
"11832245",
"15556870",
"24321454"
] | [
"The anaphase promoting complex/cyclosome: a machine designed to destroy.",
"Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex.",
"Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylat... | [
2006,
2001,
2008,
2015,
2016,
2002,
2000,
2002,
2004,
2014
] | 10 | [] | [] | 0 | 0 | null | [
"Rhabditomorpha"
] | [
27
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | APC1, N-terminal domain, nematodes | APC1, N-terminal domain, nematodes | APC1_N_nem | 2 |
IPR060404 | 60,404 | CCDC17, C-terminal domain | CCDC17_C | Domain | 725 | false | false | This entry represents the C-terminal domain of CCDC17 (coiled-coil domain-containing protein 17) from animals. This domain follows the coiled-coil region and contains a disordered region with basic and acidic residues. The specific function of this C-terminal domain remains to be determined. CCDC17 contains multiple co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28455"
] | [
"CCDC17_C"
] | [
725
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
725
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
4
] | 4 | true | Domain | CCDC17, C-terminal domain | CCDC17, C-terminal domain | CCDC17_C | 9 |
IPR060405 | 60,405 | CCDC17, middle coiled-coil domain | CCDC17_middle_coil | Domain | 759 | false | false | This entry represents the middle coiled-coil region of CCDC17 (coiled- coil domain-containing protein 17) found in animals. The specific function of this middle coiled-coil domain remains to be determined. CCDC17 contains multiple coiled-coil regions, with this middle domain representing the largest coiled-coil region ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28454"
] | [
"CCDC17_middle_coil"
] | [
759
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
759
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
2
] | 4 | true | Domain | CCDC17, middle coiled-coil domain | CCDC17, middle coiled-coil domain | CCDC17_middle_coil | 6 |
IPR060406 | 60,406 | SLMAP-like, first coiled-coil | CC1_SLMAP-like | Domain | 5,281 | false | false | This entry represents the first coiled-coil (CC1) domain found in STRIPAK-associated proteins including sarcolemmal membrane-associated protein (SLMAP) and TRAF3-interacting JNK-activating modulator (T3JAM/TRAF3IP3). In SLMAP, this domain is responsible for binding suppressor of IKBKE 1 (SIKE1), facilitating the format... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27557"
] | [
"CC1_STRIPAK"
] | [
5281
] | 1 | [] | [] | [] | 0 | [
"6akm"
] | 1 | [
"PUB00073026",
"PUB00109891",
"PUB00146390",
"PUB00146391",
"PUB00161851",
"PUB00161852"
] | [
"15086317",
"15591093",
"30573680",
"14572659",
"26195727",
"31390091"
] | [
"Regulated expression and temporal induction of the tail-anchored sarcolemmal-membrane-associated protein is critical for myoblast fusion.",
"Molecular properties of cardiac tail-anchored membrane protein SLMAP are consistent with structural role in arrangement of excitation-contraction coupling apparatus.",
"T... | [
2004,
2005,
2019,
2003,
2015,
2019
] | 6 | [] | [
"IPR060407"
] | 0 | 1 | 0 | [
"Opisthokonta"
] | [
5281
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
15,
2,
24,
9,
11
] | 6 | true | Domain | SLMAP-like, first coiled-coil | SLMAP-like, first coiled-coil | CC1_SLMAP-like | 1 |
IPR060407 | 60,407 | Sarcolemmal membrane-associated protein, first coiled-coil | CC1_SLMAP | Domain | 3,962 | false | false | This entry represents the first coiled-coil in Sarcolemmal membrane-associated protein (SLMAP) proteins found in animals. In SLMAP, this domain is responsible for binding suppressor of IKBKE 1 (SIKE1), facilitating the formation of the extended (SIKE1:SLMAP)STRIPAK complex that regulates Hippo signalling and cell growt... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd21911"
] | [
"CC1_SLMAP"
] | [
3962
] | 1 | [] | [] | [] | 0 | [
"6akm"
] | 1 | [
"PUB00073026",
"PUB00109891"
] | [
"15086317",
"15591093"
] | [
"Regulated expression and temporal induction of the tail-anchored sarcolemmal-membrane-associated protein is critical for myoblast fusion.",
"Molecular properties of cardiac tail-anchored membrane protein SLMAP are consistent with structural role in arrangement of excitation-contraction coupling apparatus."
] | [
2004,
2005
] | 2 | [
"IPR060406"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
3962
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
13,
20,
5,
8
] | 5 | true | Domain | Sarcolemmal membrane-associated protein, first coiled-coil | Sarcolemmal membrane-associated protein, first coiled-coil | CC1_SLMAP | 7 |
IPR060408 | 60,408 | MTUS1/CCDC69, second coiled-coil domain | MTUS1_CCDC69_CC2 | Domain | 5,147 | false | false | This entry represents the second coiled-coil domain found in the MTUS1/CCDC69 and related proteins. This domain is present in microtubule-associated tumour suppressor 1 (MTUS1) and coiled-coil domain- containing protein 69 (CCDC69). Both proteins contain extensive coiled-coil regions that mediate protein-protein intera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27558"
] | [
"MTUS1_CCDC69_CC2"
] | [
5147
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070905",
"PUB00070906",
"PUB00070907",
"PUB00078493",
"PUB00162172",
"PUB00162173",
"PUB00162174",
"PUB00162175",
"PUB00162515",
"PUB00162516"
] | [
"15123706",
"12692079",
"19794912",
"19543227",
"15539617",
"20962590",
"17068200",
"12919681",
"30651135",
"39638803"
] | [
"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.",
"Identification of a new tumor suppressor gene located at chromosome 8p21.3-22.",
"8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor ... | [
2004,
2003,
2009,
2009,
2005,
2010,
2007,
2003,
2019,
2024
] | 10 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Rossellomorea oryzaecorticis"
] | [
5146,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
35,
14,
8,
10,
16
] | 6 | true | Domain | MTUS1/CCDC69, second coiled-coil domain | MTUS1/CCDC69, second coiled-coil domain | MTUS1_CCDC69_CC2 | 6 |
IPR060410 | 60,410 | APC1, TPR-like domain | TPR_APC1 | Domain | 5,039 | false | false | This entry represents a TPR-like domain found in anaphase-promoting complex subunit 1 proteins (APC1). This domain is part of the multi-domain architecture of APC1, which is a component of the anaphase-promoting complex/cyclosome (APC/C). This domain is found across eukaryotes including metazoans, fungi and plants. APC... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27562"
] | [
"APC1_4th"
] | [
5039
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-983168",
"R-DDI-141430",
"R-DDI-174048",
"R-DDI-174084",
"R-DDI-174154",
"R-DDI-174178",
"R-DDI-174184",
"R-DDI-176407",
"R-DDI-176408",
"R-DDI-176409",
"R-DDI-176412",
"R-DDI-179409",
"R-DDI-2467813",
"R-DDI-2559582",
"R-DDI-69017",
"R-DDI-983168",
"R-HSA-141430",
"R-HSA-17... | [
"REACTOME:R-CEL-983168",
"REACTOME:R-DDI-141430",
"REACTOME:R-DDI-174048",
"REACTOME:R-DDI-174084",
"REACTOME:R-DDI-174154",
"REACTOME:R-DDI-174178",
"REACTOME:R-DDI-174184",
"REACTOME:R-DDI-176407",
"REACTOME:R-DDI-176408",
"REACTOME:R-DDI-176409",
"REACTOME:R-DDI-176412",
"REACTOME:R-DDI-179... | 52 | [
"4ui9",
"5a31",
"5g04",
"5g05",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"6q6g",
"6q6h",
"6tlj",
"6tm5",
"6tnt",
"8a3t",
"8a5y",
"8a61",
"8pkp",
"8tar",
"8tau",
"9gaw",
"9n9r",
"9n9s"
] | 23 | [
"PUB00055977",
"PUB00057287",
"PUB00057288",
"PUB00091489",
"PUB00098994"
] | [
"16896351",
"11179667",
"17942546",
"26083744",
"27601667"
] | [
"The anaphase promoting complex/cyclosome: a machine designed to destroy.",
"Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex.",
"Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylat... | [
2006,
2001,
2008,
2015,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Candidatus Phytoplasma melaleucae",
"Eukaryota"
] | [
1,
5038
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
4,
1,
3,
3,
1,
4,
4,
1,
1,
10
] | 12 | true | Domain | APC1, TPR-like domain | APC1, TPR-like domain | TPR_APC1 | 6 |
IPR060411 | 60,411 | APC1, C-terminal domain, nematodes | APC1_C_nem | Domain | 21 | false | false | This entry represents the C-terminal helical domain found in APC1 in nematodes. Its specific function remains to be determined. APC1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27564"
] | [
"APC1_C_nematodes"
] | [
21
] | 1 | [
"REACTOME"
] | [
"R-CEL-983168"
] | [
"REACTOME:R-CEL-983168"
] | 1 | [] | 0 | [
"PUB00055977",
"PUB00057287",
"PUB00057288",
"PUB00091489",
"PUB00098994",
"PUB00161792",
"PUB00161793",
"PUB00161794",
"PUB00161795",
"PUB00161796"
] | [
"16896351",
"11179667",
"17942546",
"26083744",
"27601667",
"11861581",
"11134076",
"11832245",
"15556870",
"24321454"
] | [
"The anaphase promoting complex/cyclosome: a machine designed to destroy.",
"Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex.",
"Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylat... | [
2006,
2001,
2008,
2015,
2016,
2002,
2000,
2002,
2004,
2014
] | 10 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
21
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | APC1, C-terminal domain, nematodes | APC1, C-terminal domain, nematodes | APC1_C_nem | 5 |
IPR060412 | 60,412 | ELF3-like, helical domain | ELF3-like_helical | Domain | 5,464 | false | false | This entry represents an helical domain found in ELF3 and related proteins including Hd17 (also known as Protein HEADING DATE 3B and ELF3-1) from rice. This domain adopts an all-helical fold. The specific function of this domain remains to be determined. ELF3 proteins are involved in circadian clock regulation and phot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27565"
] | [
"ELF3_helical"
] | [
5464
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089431",
"PUB00089433",
"PUB00149930",
"PUB00161925",
"PUB00161926",
"PUB00161927",
"PUB00161928",
"PUB00161929",
"PUB00161930"
] | [
"11804815",
"22399582",
"22307044",
"22422935",
"22912900",
"22888152",
"25757473",
"11402161",
"22327739"
] | [
"ELF3: a circadian safeguard to buffer effects of light.",
"Natural variation in Hd17, a homolog of Arabidopsis ELF3 that is involved in rice photoperiodic flowering.",
"ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock.",
"Ef7 encodes an ELF3-like... | [
2002,
2012,
2012,
2012,
2012,
2013,
2015,
2001,
2012
] | 9 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
5464
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
46,
28,
63
] | 3 | true | Domain | ELF3-like, helical domain | ELF3-like, helical domain | ELF3-like_helical | 2 |
IPR060413 | 60,413 | Transcription factor KpeA/SAT20-like, C-terminal domain | KpeA/SAT20-like_C | Domain | 4,560 | false | false | This entry represents the C-terminal domain of KpeA transcription factors and Satratoxin biosynthesis SC3 cluster transcription factor SAT20 found in fungi. These proteins contain a Zn(2)-C6 fungal-type DNA-binding domain ( ) and ( ) and function as transcriptional regulators involved in secondary metabolism and conidi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27566"
] | [
"KpeA"
] | [
4560
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00087317",
"PUB00162118"
] | [
"25015739",
"30790620"
] | [
"Comparative genome sequencing reveals chemotype-specific gene clusters in the toxigenic black mold Stachybotrys.",
"A unique Zn(II)<sub>2</sub>-Cys<sub>6</sub>-type protein, KpeA, is involved in secondary metabolism and conidiation in Aspergillus oryzae."
] | [
2014,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4560
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
9
] | 1 | true | Domain | Transcription factor KpeA/SAT20-like, C-terminal domain | Transcription factor KpeA/SAT20-like, C-terminal domain | KpeA/SAT20-like_C | 7 |
IPR060414 | 60,414 | Excinuclease Cho, C-terminal domain | Cho_C | Domain | 2,516 | false | false | This entry represents the C-terminal domain of excinuclease Cho (also known as UvrC homolog), a protein involved in nucleotide excision repair in bacteria. Cho acts as an alternative endonuclease that can substitute for UvrC in certain DNA repair situations. The full-length Cho protein contains an N-terminal RNase T do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27115"
] | [
"Cho_C"
] | [
2516
] | 1 | [
"EC"
] | [
"3.1.25.-"
] | [
"EC:3.1.25.-"
] | 1 | [] | 0 | [
"PUB00102495"
] | [
"11818552"
] | [
"Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"ecological metagenomes"
] | [
2507,
2,
7
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Excinuclease Cho, C-terminal domain | Excinuclease Cho, C-terminal domain | Cho_C | 8 |
IPR060415 | 60,415 | RALGAPA1-like, N-terminal domain | RALGAPA1-like_N | Domain | 4,982 | false | false | This entry represents the N-terminal domain found in Ral GTPase-activating protein subunit alpha-1 (RALGAPA1) and RALGAPA2 proteins. This domain is located at the N-terminal region of RALGAPA1, which functions as the catalytic subunit of the heterodimeric RalGAP1 complex. This N-terminal domain is found in vertebrates ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27567"
] | [
"RALGAPA1_N"
] | [
4982
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9013407",
"R-HSA-1445148",
"R-HSA-9013407",
"R-MMU-9013407",
"R-RNO-9013407"
] | [
"REACTOME:R-DME-9013407",
"REACTOME:R-HSA-1445148",
"REACTOME:R-HSA-9013407",
"REACTOME:R-MMU-9013407",
"REACTOME:R-RNO-9013407"
] | 5 | [
"9qu1",
"9qwp"
] | 2 | [
"PUB00062933",
"PUB00162517",
"PUB00162518"
] | [
"19520869",
"17765682",
"21148297"
] | [
"Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.",
"Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c.",
"A Ral GAP complex links PI 3-kinase/Akt signaling to Ra... | [
2009,
2007,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4982
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
31,
2,
7,
10,
15
] | 6 | true | Domain | RALGAPA1-like, N-terminal domain | RALGAPA1-like, N-terminal domain | RALGAPA1-like_N | 3 |
IPR060416 | 60,416 | Druantia protein DruE, beta-barrel domain | DruE_b-brl | Domain | 1,296 | false | false | This entry represents a β-barrel domain which is found in the Druantia protein DruE and related bacterial proteins. This domain is also found in the Putative uncharacterized protein YjiV which is could be, however, the product of a pseudogene. DruE is a component of antiviral defense system Druantia type I, composed of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27116"
] | [
"YjiV_N"
] | [
1296
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097806"
] | [
"29371424"
] | [
"Systematic discovery of antiphage defense systems in the microbial pangenome."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
26,
1257,
4,
9
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Druantia protein DruE, beta-barrel domain | Druantia protein DruE, beta-barrel domain | DruE_b-brl | 3 |
IPR060417 | 60,417 | Platelet glycoprotein Ib beta chain, C-terminal | GP1BB_C | Domain | 709 | false | false | This entry represents the C-terminal region platelet glycoprotein Ib beta chain. This is a transmembrane helix located at the C-terminal end of the leucine-rich repeat region [ , ]. Platelet glycoprotein Ib beta is a component of the GP1b-IX-V complex that participates in platelet adhesion by binding to von Willebrand ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28456"
] | [
"GP1BB_C"
] | [
709
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140837",
"R-HSA-430116",
"R-HSA-75892",
"R-HSA-76009",
"R-HSA-9673221",
"R-HSA-9845620",
"R-HSA-9846298",
"R-MMU-140837",
"R-MMU-430116",
"R-MMU-75892",
"R-MMU-76009",
"R-RNO-140837",
"R-RNO-430116",
"R-RNO-76009"
] | [
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-430116",
"REACTOME:R-HSA-75892",
"REACTOME:R-HSA-76009",
"REACTOME:R-HSA-9673221",
"REACTOME:R-HSA-9845620",
"REACTOME:R-HSA-9846298",
"REACTOME:R-MMU-140837",
"REACTOME:R-MMU-430116",
"REACTOME:R-MMU-75892",
"REACTOME:R-MMU-76009",
"REACTOME:R-RNO-1408... | 14 | [
"8wfs"
] | 1 | [
"PUB00161990",
"PUB00161991"
] | [
"3353370",
"21908432"
] | [
"The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.",
"Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera."
] | [
1988,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
709
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
1
] | 4 | true | Domain | Platelet glycoprotein Ib beta chain, C-terminal | Platelet glycoprotein Ib beta chain, C-terminal | GP1BB_C | 8 |
IPR060420 | 60,420 | Mitochondrial fission factor interactor, C-terminal domain | MFI_C | Domain | 779 | false | false | This entry represents the C-terminal domain of mitochondrial fission factor interactor (MFI), also known as C11orf65 in human. The specific function of this C-terminal domain remains to be determined. MFI acts as an inhibitor of mitochondrial fission as it interacts with mitochondrial fission factor (MFF) and prevents ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28463"
] | [
"MFI_C"
] | [
779
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161725"
] | [
"30059978"
] | [
"A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
779
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
2,
6
] | 4 | true | Domain | Mitochondrial fission factor interactor, C-terminal domain | Mitochondrial fission factor interactor, C-terminal domain | MFI_C | 8 |
IPR060422 | 60,422 | FliB lysine N-methylase, C-terminal | FliB_C | Domain | 2,374 | false | false | This entry represents the C-terminal α-helical domain of FliB lysine N-methylase from Salmonella and related bacteria, including Flagellar biosynthetic protein FliV. FliB post-translationally modifies flagellin by methylation of the epsilon amino group of surface-exposed lysine residues. The full-length FliB protein fu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27117"
] | [
"FliB_C"
] | [
2374
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066745"
] | [
"9168604"
] | [
"The flagellin N-methylase gene fliB and an adjacent serovar-specific IS200 element in Salmonella typhimurium."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
2358,
16
] | 2 | [] | [] | 0 | true | Domain | FliB lysine N-methylase, C-terminal | FliB lysine N-methylase, C-terminal | FliB_C | 7 |
IPR060423 | 60,423 | Cerebellar degeneration-related protein 2-like, C-terminal domain | CDR2-like_C | Domain | 2,585 | false | false | This entry represents the C-terminal domain of cerebellar degeneration-related protein 2 (CDR2) and CDR2-like (CDR2L) proteins. CDR2 proteins are found in vertebrates and are associated with paraneoplastic cerebellar degeneration [ , ], where they serve as autoantigens. This domain is approximately 85 residues in lengt... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27644"
] | [
"CDR2_C"
] | [
2585
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00149541",
"PUB00162519",
"PUB00162520"
] | [
"21183079",
"31148214",
"39795928"
] | [
"A tissue-specific atlas of mouse protein phosphorylation and expression.",
"CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration.",
"Roles of CDR2 and CDR2L in Anti-Yo Paraneoplastic Cerebellar Degeneration: A Literature Review."
] | [
2010,
2019,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2585
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
1,
2,
5,
6
] | 5 | true | Domain | Cerebellar degeneration-related protein 2-like, C-terminal domain | Cerebellar degeneration-related protein 2-like, C-terminal domain | CDR2-like_C | 3 |
IPR060424 | 60,424 | MG185/MG260-like, N-terminal domain | MG185_MG260-like_N | Domain | 177 | false | false | This entry represents a domain in MG185/MG260/MPN_363 and similar lipoproteins found in bacteria. This domain is found in uncharacterised lipoproteins that are anchored to the cell membrane via lipid modifications. Members contain a signal peptide and lipid anchor sites for N-palmitoyl cysteine and S-diacylglycerol cys... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27319"
] | [
"MG185_MG260"
] | [
177
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
177
] | 1 | [] | [] | 0 | true | Domain | MG185/MG260-like, N-terminal domain | MG185/MG260-like, N-terminal domain | MG185_MG260-like_N | 1 |
IPR060426 | 60,426 | MJECL34-like domain | MJECL34-like_dom | Domain | 39 | false | false | This entry represents a domain found in MJECL34 from Methanocaldococcus jannaschii and similar uncharacterised proteins found in archaea and bacteria. The proteins are approximately 295 amino acids in length. The function of this domain remains to be determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27344"
] | [
"MJECL34"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Pseudomonadati"
] | [
25,
14
] | 2 | [] | [] | 0 | true | Domain | MJECL34-like domain | MJECL34-like domain | MJECL34-like_dom | 1 |
IPR060428 | 60,428 | Type II restriction enzyme MwoI, N-terminal domain | MwoI_N | Domain | 54 | false | false | This entry represents the N-terminal domain of a group of MwoI type II restriction endonucleases found predominantly in bacteria with some archaeal members, including MwoI from Methanothermobacter wolfeii, which recognises the double-stranded sequence 5'-GCNNNNNNNGC-3' and cleaves after N-5 [ ]. The proteins are approx... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27366"
] | [
"MwoI"
] | [
54
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162181"
] | [
"2663652"
] | [
"Characterization and cloning of MwoI (GCN7GC), a new type-II restriction-modification system from Methanobacterium wolfei."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati",
"marine sediment metagenome"
] | [
49,
3,
2
] | 3 | [] | [] | 0 | true | Domain | Type II restriction enzyme MwoI, N-terminal domain | Type II restriction enzyme MwoI, N-terminal domain | MwoI_N | 7 |
IPR060429 | 60,429 | VOPP1, N-terminal domain | VOPP1_N | Domain | 778 | false | false | This entry represents the N-terminal domain of VOPP1 (WW domain binding protein VOPP1), also known as ECOP (EGFR-coamplified and overexpressed protein). VOPP1 is a single-pass type I membrane protein that localises to cytoplasmic vesicle membranes, late endosomes and lysosomes. It increases the transcriptional activity... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27964"
] | [
"VOPP1_N"
] | [
778
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060255"
] | [
"15735698"
] | [
"ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
778
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2,
5
] | 4 | true | Domain | VOPP1, N-terminal domain | VOPP1, N-terminal domain | VOPP1_N | 6 |
IPR060430 | 60,430 | VOPP1 domain | VOPP1_dom | Domain | 1,270 | false | false | This entry represents a domain found in VOPP1 (WW domain binding protein VOPP1), also known as ECOP (EGFR-coamplified and overexpressed protein). It is adjacent [ ]. VOPP1 is a single-pass type I membrane protein that localises to cytoplasmic vesicle membranes, late endosomes and lysosomes. It increases the transcripti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27963"
] | [
"VOPP1_C"
] | [
1270
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060255"
] | [
"15735698"
] | [
"ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1270
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
8,
4,
7
] | 4 | true | Domain | VOPP1 domain | VOPP1 domain | VOPP1_dom | 1 |
IPR060431 | 60,431 | Prepilin peptidase-dependent protein B, conserved domain | PpdB_dom | Domain | 2,445 | false | false | This entry represents the prepilin peptidase-dependent protein B (PpdB) family found in Escherichia coli, Haemophilus influenzae and other Gram-negative bacteria. These proteins typically contain a single N-terminal transmembrane helix. PpdB proteins possess a characteristic N-terminal leader sequence that is cleaved b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27121"
] | [
"PpdB"
] | [
2445
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003850"
] | [
"7934814"
] | [
"Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Acyrthosiphon pisum",
"Bacteria",
"ecological metagenomes"
] | [
1,
2436,
8
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Prepilin peptidase-dependent protein B, conserved domain | Prepilin peptidase-dependent protein B, conserved domain | PpdB_dom | 7 |
IPR060432 | 60,432 | Four-jointed box protein, middle domain | FJX1_middle | Domain | 920 | false | false | This entry represents the kinase-like domain found in four-jointed box proteins (FJX1/FJ family). In Drosophila, the four-jointed protein is a functional Golgi-resident serine/threonine kinase that phosphorylates cadherin domains of Fat and Dachsous proteins during their transit through the Golgi apparatus [ ]. The kin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28411"
] | [
"FJX1_middle"
] | [
920
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056704",
"PUB00060261",
"PUB00125684"
] | [
"18028897",
"16145673",
"18635802"
] | [
"The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.",
"Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.",
"Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains."
] | [
2007,
2005,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Endozoicomonas numazuensis"
] | [
919,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
1,
2
] | 5 | true | Domain | Four-jointed box protein, middle domain | Four-jointed box protein, middle domain | FJX1_middle | 7 |
IPR060434 | 60,434 | Rv1109c-like, N-terminal bi-helical domain | Rv1109c_N | Domain | 1,014 | false | false | This entry represents the N-terminal bi-helical domain of uncharacterised protein Rv1109c from Mycobacterium tuberculosis and related mycobacteria. The Rv1109c protein has been detected in the cytosol, plasma membrane, and peptidoglycan-based cell wall fractions [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27128"
] | [
"Rv1109c_N"
] | [
1014
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162132",
"PUB00162284"
] | [
"21969609",
"17259624"
] | [
"Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.",
"Experimental determination of translational starts using peptide mass mapping and tandem mass spectrometry within the proteome of Mycobacterium tuberculosis."
] | [
2011,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"freshwater metagenome"
] | [
1013,
1
] | 2 | [] | [] | 0 | true | Domain | Rv1109c-like, N-terminal bi-helical domain | Rv1109c-like, N-terminal bi-helical domain | Rv1109c_N | 5 |
IPR060435 | 60,435 | XisA/XisC excisase, second domain | XisAC_2nd | Domain | 447 | false | false | This entry represents the second domain found in XisA and XisC excisases from Nostoc sp. PCC 7120 and related cyanobacteria. These proteins are site-specific recombinases essential for DNA excision during heterocyst differentiation. XisA is necessary for excision of the 11 kb nifD element [ ], while XisC is required fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27132"
] | [
"XisAC_2nd"
] | [
447
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162401",
"PUB00162402"
] | [
"3144039",
"7846053"
] | [
"Genome rearrangement and nitrogen fixation in Anabaena blocked by inactivation of xisA gene.",
"Programmed DNA rearrangement of a cyanobacterial hupL gene in heterocysts."
] | [
1988,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteriophage sp.",
"Cyanobacteriota"
] | [
1,
446
] | 2 | [] | [] | 0 | true | Domain | XisA/XisC excisase, second domain | XisA/XisC excisase, second domain | XisAC_2nd | 1 |
IPR060436 | 60,436 | CFAP99, V-shaped coiled-coil domain | CFAP99_CC | Domain | 1,500 | false | false | This entry represents a large V-shaped coiled-coil domain found in CFAP99 (cilia- and flagella-associated protein 99) and similar proteins mainly found in animals. CFAP99 localises to cilia and flagella in motile ciliated cells. The full-length protein contains multiple coiled-coil regions that are predicted to form ex... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27956"
] | [
"CFAP99_CC"
] | [
1500
] | 1 | [] | [] | [] | 0 | [
"7n6g",
"7sqc",
"9ijj"
] | 3 | [
"PUB00153933"
] | [
"35578023"
] | [
"Ciliary central apparatus structure reveals mechanisms of microtubule patterning."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1500
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
1,
1
] | 4 | true | Domain | CFAP99, V-shaped coiled-coil domain | CFAP99, V-shaped coiled-coil domain | CFAP99_CC | 5 |
IPR060437 | 60,437 | Glutathione transferase 3, N-terminal domain | GTT3_N | Domain | 56 | false | false | This entry represents the N-terminal domain of GTT3 (glutathione transferase 3) from Saccharomyces cerevisiae and similar sequences found in Saccharomycetales. GTT3 is a nuclear membrane protein that localises to the nuclear periphery [ ]. It contains two transmembrane helices and is classified as a multi-pass membrane... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27945"
] | [
"GTT3_N"
] | [
56
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016470"
] | [
"14562095"
] | [
"Global analysis of protein localization in budding yeast."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
56
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Glutathione transferase 3, N-terminal domain | Glutathione transferase 3, N-terminal domain | GTT3_N | 9 |
IPR060438 | 60,438 | CEP162, third coiled-coil domain | CEP162_coil_3 | Domain | 1,087 | false | false | This entry represents a coiled-coil domain found near the C-terminal of CEP162 (centrosomal protein of 162 kDa) and similar animal proteins. CEP162 is required to promote assembly of the transition zone in primary cilia by specifically recognising and binding the axonemal microtubule [ ]. The protein localises to the d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27944"
] | [
"CEP162_coil_mid"
] | [
1087
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [
"PUB00088387"
] | [
"23644468"
] | [
"CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1087
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
2,
2,
4
] | 4 | true | Domain | CEP162, third coiled-coil domain | CEP162, third coiled-coil domain | CEP162_coil_3 | 5 |
IPR060441 | 60,441 | CEP162, first coiled-coil domain | CEP162_CC_1 | Domain | 1,192 | false | false | This entry represents the first coiled-coil domain of centrosomal protein of 162 kDa (CEP162) and similar animal proteins. The specific function of this domain remains to be determined. CEP162 is required to promote assembly of the transition zone in primary cilia by specifically recognising and binding the axonemal mi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27825"
] | [
"CEP162_helical_1"
] | [
1192
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [
"PUB00088387"
] | [
"23644468"
] | [
"CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Paenibacillus segetis"
] | [
1191,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
2,
2,
3
] | 4 | true | Domain | CEP162, first coiled-coil domain | CEP162, first coiled-coil domain | CEP162_CC_1 | 4 |
IPR060442 | 60,442 | CEP162, second coiled-coil domain | CEP162_CC_2 | Domain | 1,463 | false | false | This entry represents the second coiled-coil domain of centrosomal protein of 162 kDa (CEP162) and similar animal proteins. The specific function of this domain remains to be determined. CEP162 is required to promote assembly of the transition zone in primary cilia by specifically recognising and binding the axonemal m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27821"
] | [
"CEP162_helical_3"
] | [
1463
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [
"PUB00088387"
] | [
"23644468"
] | [
"CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Caballeronia catudaia",
"Eukaryota"
] | [
1,
1462
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
17,
2,
2,
3
] | 4 | true | Domain | CEP162, second coiled-coil domain | CEP162, second coiled-coil domain | CEP162_CC_2 | 6 |
IPR060443 | 60,443 | SCD2, coiled-coil domain | SCD2_CC | Domain | 2,035 | false | false | This entry represents a coiled-coil domain of SCD2 from Arabidopsis thaliana and similar plant sequences. SCD2 is involved in growth and development through its role in cytokinesis and polarised cell expansion [ ]. It is required for plasma membrane internalisation and functions in clathrin-mediated membrane traffickin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27823"
] | [
"SCD2_helical_N"
] | [
2035
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090816"
] | [
"24179130"
] | [
"Mediation of clathrin-dependent trafficking during cytokinesis and cell expansion by Arabidopsis stomatal cytokinesis defective proteins."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces sp. SID12501"
] | [
2034,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
30,
9,
15
] | 3 | true | Domain | SCD2, coiled-coil domain | SCD2, coiled-coil domain | SCD2_CC | 9 |
IPR060444 | 60,444 | BrxC, C-terminal alpha-beta domain | BrxC_ab | Domain | 543 | false | false | This entry represents a small α-β domain found at the C-terminal of BrxC, a core component of the BREX type 1 bacteriophage exclusion system. BrxC is part of a multi-gene system that provides immunity against bacteriophages by preventing phage DNA replication without degrading the phage DNA [ ]. The specific function o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27153"
] | [
"BrxC_helical"
] | [
543
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093365"
] | [
"25452498"
] | [
"BREX is a novel phage resistance system widespread in microbial genomes."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Siphoviridae sp. ctSA812",
"metagenomes"
] | [
499,
34,
1,
9
] | 4 | [] | [] | 0 | true | Domain | BrxC, C-terminal alpha-beta domain | BrxC, C-terminal alpha-beta domain | BrxC_ab | 7 |
IPR060445 | 60,445 | PARP10, KH-domain type I | KH_PARP10 | Domain | 476 | false | false | This eukaryotic type KH domain is found in human Protein mono -ADP-ribosyltransferase PARP10 and similar proteins from vertebrates. PARP10 mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins and is involved in translation DNA synthesis in response to DNA damage [ , , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27824"
] | [
"KH_PARP10"
] | [
476
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-196807",
"R-HSA-9683610",
"R-HSA-9694631"
] | [
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9683610",
"REACTOME:R-HSA-9694631"
] | 3 | [] | 0 | [
"PUB00146699",
"PUB00155694",
"PUB00162110",
"PUB00162111",
"PUB00162112"
] | [
"25043379",
"18851833",
"23332125",
"23474714",
"24695737"
] | [
"Family-wide analysis of poly(ADP-ribose) polymerase activity.",
"Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.",
"ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation.",
"Macrodomain-containing proteins are new mono-ADP-ri... | [
2014,
2008,
2013,
2013,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
476
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
1,
2
] | 4 | true | Domain | PARP10, KH-domain type I | PARP10, KH-domain type I | KH_PARP10 | 1 |
IPR060446 | 60,446 | Adenylate cyclase activation protein git1-like, third TPR-like domain | Git1-like_TPR-like_3rd | Domain | 1,600 | false | false | This entry represents the third domain of yeast adenylate cyclase activation protein git1 and similar fungal sequences. Git1 is involved in the glucose/cAMP signalling pathway and is required for maintaining basal cAMP levels and for producing a glucose-triggered cAMP response [ ]. This protein interacts with adenylate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27826"
] | [
"Git1_TPR-like_3rd"
] | [
1600
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161981"
] | [
"16489217"
] | [
"Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1600
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2
] | 2 | true | Domain | Adenylate cyclase activation protein git1-like, third TPR-like domain | Adenylate cyclase activation protein git1-like, third TPR-like domain | Git1-like_TPR-like_3rd | 1 |
IPR060447 | 60,447 | ORF11, beta-sandwich domain | ORF11_beta | Domain | 428 | false | false | This entry represents a small β-sandwich domain found in an Uncharacterized 10.2 kDa protein in HgiCIIM 5'region (ORF11) from Herpetosiphon aurantiacus. The protein is located within the HgiBI restriction-modification system and may function as a silencing control element for regulation of the restriction system [ , ].... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27154"
] | [
"YB1M_beta"
] | [
428
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161588",
"PUB00162411"
] | [
"7607523",
"2062638"
] | [
"Organization and gene expression within restriction-modification systems of Herpetosiphon giganteus.",
"Isolation and genetic structure of the AvaII isoschizomeric restriction-modification system HgiBI from Herpetosiphon giganteus Hpg5: M.HgiBI reveals high homology to M.BanI."
] | [
1995,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Daphnia pulex",
"ecological metagenomes"
] | [
77,
334,
1,
16
] | 4 | [] | [] | 0 | true | Domain | ORF11, beta-sandwich domain | ORF11, beta-sandwich domain | ORF11_beta | 1 |
IPR060448 | 60,448 | Adenylate cyclase activation protein git1, second domain | Git1_2nd | Domain | 5 | false | false | This entry represents the second domain of adenylate cyclase activation protein git1 from Schizosaccharomyces species. Git1 is involved in the glucose/cAMP signalling pathway and is required for maintaining basal cAMP levels and for producing a glucose-triggered cAMP response [ ]. The full-length protein interacts with... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27827"
] | [
"Git1_2nd"
] | [
5
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161981"
] | [
"16489217"
] | [
"Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Schizosaccharomyces"
] | [
5
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Domain | Adenylate cyclase activation protein git1, second domain | Adenylate cyclase activation protein git1, second domain | Git1_2nd | 6 |
IPR060449 | 60,449 | PTTG1IP, C-terminal domain | PTTG1IP_C | Domain | 1,438 | false | false | This entry represents the C-terminal cytoplasmic domain of animal PTTG1IP (pituitary tumor-transforming gene 1 protein-interacting protein). PTTG1IP is is a single-pass type I membrane protein that interacts with PTTG1 and may facilitate PTTG1 nuclear translocation [ ]. This cytoplasmic domain contains a predicted coil... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27838"
] | [
"PTTG1IP_C"
] | [
1438
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162270"
] | [
"10781616"
] | [
"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Mycolicibacterium",
"Opisthokonta"
] | [
2,
1436
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
4,
2
] | 4 | true | Domain | PTTG1IP, C-terminal domain | PTTG1IP, C-terminal domain | PTTG1IP_C | 7 |
IPR060450 | 60,450 | Tubulin polyglutamylase TTLL11, EF-hand domain | EF_TTLL11 | Domain | 1,288 | false | false | This EF-hand domain is found at the C-terminal of human Tubulin polyglutamylase TTLL11, which is required for CCSAP localisation to both spindle and cilia microtubules [ ]. Members of this group are found in animals. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27858"
] | [
"EF_TTLL11"
] | [
1288
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8955332",
"R-MMU-8955332"
] | [
"REACTOME:R-HSA-8955332",
"REACTOME:R-MMU-8955332"
] | 2 | [
"9hq4"
] | 1 | [
"PUB00066558",
"PUB00070858",
"PUB00161921"
] | [
"17499049",
"22493317",
"20530212"
] | [
"A targeted multienzyme mechanism for selective microtubule polyglutamylation.",
"CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development.",
"Tubulin polyglutamylation stimulates spastin-mediated microtubule severing."
] | [
2007,
2012,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1288
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
2,
4
] | 5 | true | Domain | Tubulin polyglutamylase TTLL11, EF-hand domain | Tubulin polyglutamylase TTLL11, EF-hand domain | EF_TTLL11 | 8 |
IPR060451 | 60,451 | Y4rL, C-terminal three-helical bundle | Y4rL_C | Domain | 675 | false | false | This entry represents a small C-terminal three-helical bundle domain found in Y4rL, a putative uncharacterised protein from Sinorhizobium fredii. The protein is encoded on the symbiotic plasmid pNGR234a and belongs to the COG2801 functional category. However, the protein could be the product of a pseudogene. The specif... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27155"
] | [
"Y4rL_C"
] | [
675
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"ecological metagenomes"
] | [
650,
3,
22
] | 3 | [] | [] | 0 | true | Domain | Y4rL, C-terminal three-helical bundle | Y4rL, C-terminal three-helical bundle | Y4rL_C | 5 |
IPR060452 | 60,452 | RP005-like, N-terminal alpha-helical domain | RP005_N | Domain | 437 | false | false | This entry represents the N-terminal α-helical domain of RP005, an uncharacterised protein from Rickettsia prowazekii. The protein belongs to the COG0493 functional category. The specific function of this N-terminal domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27156"
] | [
"RP005_N"
] | [
437
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"unclassified sequences"
] | [
7,
424,
6
] | 3 | [] | [] | 0 | true | Domain | RP005-like, N-terminal alpha-helical domain | RP005-like, N-terminal alpha-helical domain | RP005_N | 9 |
IPR060453 | 60,453 | YmtS, Rossmann-like domain | YmtS_Ross | Domain | 318 | false | false | This entry represents a small Rossmann-like domain found in an uncharacterised protein from Clostridium tetanomorphum and related bacterial proteins. The protein is located in the mutS 5' region, which is part of a gene cluster involved in glutamate mutase activity [ ]. This domain adopts a Rossmann-like fold, which is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27163"
] | [
"YmtS_Ross"
] | [
318
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152387"
] | [
"8428631"
] | [
"Cloning and sequencing of glutamate mutase component E from Clostridium tetanomorphum. Organization of the mut genes."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
309,
9
] | 2 | [] | [] | 0 | true | Domain | YmtS, Rossmann-like domain | YmtS, Rossmann-like domain | YmtS_Ross | 5 |
IPR060454 | 60,454 | CROWDED NUCLEI 2-like, N-terminal domain | CRWN-like_N | Domain | 2,106 | false | false | This entry represents the N-terminal coiled-coil domain of CROWDED NUCLEI (CRWN) proteins found in plant species [ , ]. CRWN proteins are components of SUN-protein-containing LINC complexes that link the nucleoskeleton and cytoskeleton [ , , ]. These proteins are required for nuclear size control and heterochromatin or... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27881"
] | [
"CRWN_N"
] | [
2106
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090929",
"PUB00090930",
"PUB00097188",
"PUB00161890"
] | [
"24308514",
"23396599",
"32129897",
"17873096"
] | [
"Arabidopsis CROWDED NUCLEI (CRWN) proteins are required for nuclear size control and heterochromatin organization.",
"LITTLE NUCLEI 1 and 4 regulate nuclear morphology in Arabidopsis thaliana.",
"A lamin-like protein OsNMCP1 regulates drought resistance and root growth through chromatin accessibility modulatio... | [
2013,
2013,
2020,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
2102
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
21,
4,
21
] | 3 | true | Domain | CROWDED NUCLEI 2-like, N-terminal domain | CROWDED NUCLEI 2-like, N-terminal domain | CRWN-like_N | 5 |
IPR060455 | 60,455 | Aq_493, lipocalin-like domain | Aq_493_lipo | Domain | 401 | false | false | This entry represents a lipocalin-like domain found in Aq_493 from the hyperthermophilic bacterium Aquifex aeolicus and related bacterial proteins. The protein belongs to the COG1463 functional category and shows similarity to MlaD phospholipid transporters involved in intermembrane phospholipid transfer. Lipocalin-lik... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27164"
] | [
"Aq_493_lipo"
] | [
401
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"unclassified sequences"
] | [
374,
2,
25
] | 3 | [] | [] | 0 | true | Domain | Aq_493, lipocalin-like domain | Aq_493, lipocalin-like domain | Aq_493_lipo | 8 |
IPR060456 | 60,456 | CSTPP1, N-terminal domain | CSTPP1_N | Domain | 1,075 | false | false | This entry represents the N-terminal domain of centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (CSTPP1), mainly found in vertebrates. CSTPP1 is a regulator of the tubulin polyglutamylase complex that controls cytoskeletal organisation, nuclear shape, and cilium disassembly by balancing micro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27900"
] | [
"CSTPP1_N"
] | [
1075
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100741"
] | [
"34782749"
] | [
"Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1075
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
1,
4
] | 4 | true | Domain | CSTPP1, N-terminal domain | CSTPP1, N-terminal domain | CSTPP1_N | 2 |
IPR060457 | 60,457 | Fimbrial assembly protein FimB, N-terminal | FimB_N | Domain | 415 | false | false | This entry represents the N-terminal region of FimB family of fimbrial assembly proteins found in proteobacteria. FimB is involved in fimbrium biogenesis and is part of the fimbrial gene region that varies between class I and class II strains [ ]. The protein appears to be membrane-associated based on its hydrophobic c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27166"
] | [
"FimB"
] | [
415
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151047"
] | [
"1675418"
] | [
"Organization of the fimbrial gene region of Bacteroides nodosus: class I and class II strains."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"hydrothermal vent metagenome"
] | [
410,
5
] | 2 | [] | [] | 0 | true | Domain | Fimbrial assembly protein FimB, N-terminal | Fimbrial assembly protein FimB, N-terminal | FimB_N | 9 |
IPR060459 | 60,459 | Rv2311, SH3-like barrel domain | SH3_Rv2311 | Domain | 427 | false | false | This entry represents an SH3-like barrel domain found in uncharacterised proteins from Mycobacterium species, including Rv2311 from M. tuberculosis and orthologues in M. bovis. These proteins show structural similarity to P-loop containing nucleotide triphosphate hydrolases and contain domains similar to RecD-like prot... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27170"
] | [
"SH3_Rv2311"
] | [
427
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetota",
"metagenomes"
] | [
424,
3
] | 2 | [] | [] | 0 | true | Domain | Rv2311, SH3-like barrel domain | Rv2311, SH3-like barrel domain | SH3_Rv2311 | 8 |
IPR060460 | 60,460 | BamI lipocalin-like domain | BamI_lipocalin | Domain | 477 | false | false | This entry represents the lipocalin-like domain that is found in the BamI protein from Pseudomonas aeruginosa. BamI is a biofilm-associated metzincin protease inhibitor that inhibits the metalloendopeptidase Mep72 [ ]. The protein forms a protein-protein complex with Mep72, which is encoded by the adjacent coregulated ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27177"
] | [
"BamI_lipocalin"
] | [
477
] | 1 | [] | [] | [] | 0 | [
"6o38"
] | 1 | [
"PUB00161821",
"PUB00161822"
] | [
"25488299",
"31320476"
] | [
"Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.",
"The structure of <i>Acinetobacter</i>-secreted protease CpaA complexed with its chaperone CpaB reveals a novel mode of a T2SS chaperone-substrate interaction."
] | [
2015,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Anopheles melas",
"Bacteria",
"ecological metagenomes"
] | [
2,
469,
6
] | 3 | [] | [] | 0 | true | Domain | BamI lipocalin-like domain | BamI lipocalin-like domain | BamI_lipocalin | 8 |
IPR060461 | 60,461 | Aq_097-like, APC transporter | APC_Aq_097 | Family | 403 | false | false | This entry represents the Aq_097 protein, an uncharacterised integral membrane protein found in Aquifex aeolicus. The protein belongs to the APC (amino acid-polyamine- organocation) superfamily of transporters and is predicted to be a multi-pass membrane protein with 11 transmembrane helices. Aq_097 is encoded by the g... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27187"
] | [
"APC_Aq_097"
] | [
403
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"ecological metagenomes"
] | [
373,
8,
22
] | 3 | [] | [] | 0 | true | Family | Aq_097-like, APC transporter | Aq_097-like, APC transporter | APC_Aq_097 | 4 |
IPR060462 | 60,462 | 3-methyl-L-tyrosine peroxygenase | SfmD_perox | Domain | 509 | false | false | This entry represents the 3-methyl-L-tyrosine peroxygenase (SfmD) from Streptomyces lavendulae and related bacterial proteins. SfmD is an enzyme that catalyses the regioselective hydroxylation of 3-methyl-L-tyrosine to 3-hydroxy- 5-methyl-L-tyrosine using hydrogen peroxide as an oxidant [ ]. The enzyme contains one hem... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27188"
] | [
"SfmD_perox"
] | [
509
] | 1 | [] | [] | [] | 0 | [
"6vdp",
"6vdq",
"6vdz",
"6ve0",
"7kqr",
"7kqs",
"7kqt",
"7kqu",
"8r2s",
"8vmk"
] | 10 | [
"PUB00162291",
"PUB00162521"
] | [
"22187429",
"34163669"
] | [
"Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.",
"A novel catalytic heme cofactor in SfmD with a single thioether bond and a <i>bis</i>-His ligand set revealed by a <i>de novo</i> crysta... | [
2012,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
506,
3
] | 2 | [] | [] | 0 | true | Domain | 3-methyl-L-tyrosine peroxygenase | 3-methyl-L-tyrosine peroxygenase | SfmD_perox | 6 |
IPR060463 | 60,463 | YdhT, N-terminal domain | YdhT_N | Domain | 549 | false | false | This entry represents the N-terminal domain of YdhT, an uncharacterised protein from Escherichia coli, and related proteins. YdhT is encoded by gene b1669 that is part of the ydhYVWXUT operon. The protein is up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions and repressed in the p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27195"
] | [
"YdhT_N"
] | [
549
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104519"
] | [
"18227264"
] | [
"Characterization of the Escherichia coli K-12 ydhYVWXUT operon: regulation by FNR, NarL and NarP."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"plant metagenome"
] | [
534,
7,
8
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YdhT, N-terminal domain | YdhT, N-terminal domain | YdhT_N | 4 |
IPR060464 | 60,464 | FlaEY, beta-sandwich domain | FlaEY_b-sand | Domain | 193 | false | false | This entry represents a β-sandwich domain found in FlaEY, a regulatory protein from Caulobacter vibrioides and related proteins. FlaEY is a transcriptional regulator (gene CC_1465) that functions in trans to modulate the level of transcription of flagellin genes and several genes encoding chemotaxis functions [ ]. The ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27198"
] | [
"FlaEY_3rd"
] | [
193
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161962"
] | [
"2648000"
] | [
"Temporal regulation and overlap organization of two Caulobacter flagellar genes."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"hydrothermal vent metagenome"
] | [
189,
4
] | 2 | [] | [] | 0 | true | Domain | FlaEY, beta-sandwich domain | FlaEY, beta-sandwich domain | FlaEY_b-sand | 1 |
IPR060465 | 60,465 | YjiT, N-terminal domain | YjiT_N | Domain | 436 | false | false | This entry represents the N-terminal domain of YjiT, an uncharacterised protein from Escherichia coli. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27201"
] | [
"YjiT_N"
] | [
436
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Symbiodinium pilosum",
"mine drainage metagenome"
] | [
432,
1,
3
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YjiT, N-terminal domain | YjiT, N-terminal domain | YjiT_N | 6 |
IPR060466 | 60,466 | SSP120-like, C-terminal domain | SSP120-like_C | Domain | 1,516 | false | false | This entry represents the C-terminal domain of SSP120 from Saccharomyces cerevisiae, the uncharacterised calcium-binding protein C613.03 from SSchizosaccharomyces pombe and similar sequences found in fungi. SSP120 is thought to be involved in transport of plasma membrane glycoproteins through the early secretory pathwa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27909"
] | [
"C613_03_C"
] | [
1516
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053363",
"PUB00162522"
] | [
"16823372",
"26650540"
] | [
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.",
"Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins."
] | [
2006,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1516
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | SSP120-like, C-terminal domain | SSP120-like, C-terminal domain | SSP120-like_C | 3 |
IPR060467 | 60,467 | ATP synthase subunit C lysine N-methyltransferase, N-terminal domain | ATPSCKMT_N | Domain | 1,530 | false | false | This entry represents the N-terminal domain of ATP synthase subunit C lysine N-methyltransferases (ATPSCKMT/FAM173B) and similar animal sequences. ATPSCKMT is a mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, specifically ATP5MC1 and ATP5MC2 [ ]. This N-terminal region contai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27912"
] | [
"ATPSCKMT_N"
] | [
1530
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 146 | [] | 0 | [
"PUB00089647",
"PUB00092868"
] | [
"29444090",
"30530489"
] | [
"Identification of FAM173B as a protein methyltransferase promoting chronic pain.",
"Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase."
] | [
2018,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1530
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
4,
1,
2
] | 6 | true | Domain | ATP synthase subunit C lysine N-methyltransferase, N-terminal domain | ATP synthase subunit C lysine N-methyltransferase, N-terminal domain | ATPSCKMT_N | 3 |
IPR060468 | 60,468 | 5'-adenylylsulfate reductase-like 2-7, C-terminal domain | APRL2-7_C | Domain | 1,799 | false | false | This entry represents the C-terminal domain of 5'-adenylylsulfate reductase-like 2-7 (APRL2-7) proteins found in plants. APRL proteins are membrane-associated proteins containing an N-terminal signal peptide, a central thioredoxin domain, and this C-terminal region which includes a transmembrane helix. The APRL family ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27914"
] | [
"APRL7_C"
] | [
1799
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1799
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
9,
25
] | 3 | true | Domain | 5'-adenylylsulfate reductase-like 2-7, C-terminal domain | 5'-adenylylsulfate reductase-like 2-7, C-terminal domain | APRL2-7_C | 6 |
IPR060469 | 60,469 | Coiled-coil domain-containing protein 43, C-terminal domain | CCDC43_C | Domain | 1,520 | false | false | This entry represents the C-terminal domain of coiled-coil domain-containing protein 43 (CCDC43) proteins from animals and fungi. CCDC43 is typically 213-224 amino acids in length and contains multiple coiled-coil regions. This C-terminal region is predicted to form a coiled-coil. The middle region is largely disordere... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27916"
] | [
"CCDC43_C"
] | [
1520
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1520
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
1,
2
] | 5 | true | Domain | Coiled-coil domain-containing protein 43, C-terminal domain | Coiled-coil domain-containing protein 43, C-terminal domain | CCDC43_C | 7 |
IPR060470 | 60,470 | S-layer protein A, C-terminal domain | SlaA_C | Domain | 32 | false | false | This entry represents the C-terminal immunoglobulin-like domain of S-layer protein A (SlaA) found in Sulfolobales archaea. The specific function of this C-terminal immunoglobulin-like domain within the S-layer structure remains to be determined. SlaA proteins are larger than SlA proteins found in Acidianus ambivalens. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27416"
] | [
"SlaA_C"
] | [
32
] | 1 | [] | [] | [] | 0 | [
"7zcx",
"8an2",
"8an3",
"8qox",
"8qp0"
] | 5 | [
"PUB00106156",
"PUB00106157"
] | [
"16391651",
"20936123"
] | [
"Molecular organization of selected prokaryotic S-layer proteins.",
"The S-layer glycoprotein of the crenarchaeote Sulfolobus acidocaldarius is glycosylated at multiple sites with chitobiose-linked N-glycans."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Sulfolobaceae"
] | [
32
] | 1 | [] | [] | 0 | true | Domain | S-layer protein A, C-terminal domain | S-layer protein A, C-terminal domain | SlaA_C | 7 |
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