interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060471 | 60,471 | MJ0874/BtuD-like | MJ0874/BtuD-like | Domain | 1,036 | false | false | This entry represents a domain covering the full length of MJ0874, an uncharacterised protein from Methanocaldococcus jannaschii. MJ0874 is a 93 amino acid protein (gene MJ0874) from the methanogenic archaeon. This domain also covers the C-terminal in Cobalamin import ATP-binding protein BtuD from Halobacterium salinar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27219"
] | [
"MJ0874"
] | [
1036
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060729"
] | [
"16109931"
] | [
"ABC transporter for corrinoids in Halobacterium sp. strain NRC-1."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
397,
615,
24
] | 3 | [] | [] | 0 | true | Domain | MJ0874/BtuD-like | MJ0874/BtuD-like | MJ0874/BtuD-like | 6 |
IPR060472 | 60,472 | GreA-associated, TPR domain | GRAD_TPR | Domain | 233 | false | false | This entry represents a TPR domain at the C-terminal in Putative GreA-associated domains protein and at the central region in Transcription elongation factor GreA and related GreA-associated domains (GRAD) proteins. This domain is found primarily in spirochaetes, particularly Treponema species. The specific function of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27371"
] | [
"GRAD_C"
] | [
233
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
231,
2
] | 2 | [] | [] | 0 | true | Domain | GreA-associated, TPR domain | GreA-associated, TPR domain | GRAD_TPR | 2 |
IPR060473 | 60,473 | ATP phosphoribosyltransferase subunit HisZ, C-terminal domain | HisZ_C | Domain | 3,309 | false | false | This entry represents the C-terminal domain of ATP phosphoribosyltransferase regulatory subunit HisZ mainly found in gammaproteobacteria. HisZ is required for the first step of histidine biosynthesis and allows feedback regulation of ATP phosphoribosyltransferase activity by histidine. The protein functions as a hetero... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27460"
] | [
"HisZ_C"
] | [
3309
] | 1 | [] | [] | [] | 0 | [
"8oy0"
] | 1 | [
"PUB00028139",
"PUB00091719",
"PUB00162523"
] | [
"10430882",
"12269828",
"31251578"
] | [
"An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis.",
"The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis.",
"Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine... | [
1999,
2002,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3256,
2,
51
] | 3 | [] | [] | 0 | true | Domain | ATP phosphoribosyltransferase subunit HisZ, C-terminal domain | ATP phosphoribosyltransferase subunit HisZ, C-terminal domain | HisZ_C | 7 |
IPR060474 | 60,474 | PSP1-like protein, third domain | PSP1_3rd | Domain | 8,369 | false | false | This entry represents the third domain of PSP1-like proteins, exemplified by YaaT from Bacillus subtilis. YaaT is essential for the phosphorelay during initiation of sporulation and may control the level of phosphorylated Spo0A through Spo0E activity [ ]. This domain spans approximately residues 176-218 in YaaT and is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28472"
] | [
"PSP1_3rd"
] | [
8369
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00052612"
] | [
"12270811"
] | [
"Mutation in yaaT leads to significant inhibition of phosphorelay during sporulation in Bacillus subtilis."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8215,
8,
146
] | 3 | [] | [] | 0 | true | Domain | PSP1-like protein, third domain | PSP1-like protein, third domain | PSP1_3rd | 1 |
IPR060475 | 60,475 | TraD, C-terminal | TraD_C | Domain | 138 | false | false | This entry represents a C-terminal conserved region in TraD proteins found in IncP conjugative plasmids [ ]. The function has not been elucidated. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27461"
] | [
"TraD_C"
] | [
138
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094508"
] | [
"1818755"
] | [
"Gene organization and nucleotide sequence of the primase region of IncP plasmids RP4 and R751."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"plasmids"
] | [
132,
6
] | 2 | [] | [] | 0 | true | Domain | TraD, C-terminal | TraD, C-terminal | TraD_C | 7 |
IPR060476 | 60,476 | Glycogen/maltodextrin phosphorylase, C-terminal domain | GlgP_C | Domain | 4,953 | false | false | This entry represents the C-terminal domain of bacterial glycogen phosphorylase (GlgP) and maltodextrin phosphorylase (PHSG), which adopts an immunoglobulin-like fold. Glycogen phosphorylase catalyses the phosphorolytic cleavage of alpha-1,4-glycosidic bonds in glycogen to release glucose 1-phosphate, playing a central... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28476"
] | [
"GlgP_C"
] | [
4953
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.4.1.1",
"PWY-5941",
"PWY-6731",
"PWY-6737",
"PWY-7238"
] | [
"EC:2.4.1.1",
"METACYC:PWY-5941",
"METACYC:PWY-6731",
"METACYC:PWY-6737",
"METACYC:PWY-7238"
] | 5 | [] | 0 | [
"PUB00106188"
] | [
"10348846"
] | [
"Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: purification and characterization of key enzymes."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"Methanobacteriota",
"metagenomes"
] | [
4803,
1,
45,
104
] | 4 | [] | [] | 0 | true | Domain | Glycogen/maltodextrin phosphorylase, C-terminal domain | Glycogen/maltodextrin phosphorylase, C-terminal domain | GlgP_C | 5 |
IPR060477 | 60,477 | Uncharacterized protein At4g13230-like | At4g13230-like | Family | 1,435 | false | false | This entry represents a family of uncharacterised proteins found in plants, exemplified by At4g13230 from Arabidopsis thaliana. The protein is 120 amino acids in length and contains an N-terminal signal peptide, indicating targeting to the secretory pathway. The protein contains disordered regions at residues, with the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28479"
] | [
"At4g13230"
] | [
1435
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bioreactor metagenome"
] | [
45,
1389,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
4,
4
] | 3 | true | Family | Uncharacterized protein At4g13230-like | Uncharacterized protein At4g13230-like | At4g13230-like | 8 |
IPR060478 | 60,478 | DNA-binding protein Fis, N-terminal domain | Fis_N | Domain | 3,322 | false | false | This entry represents the N-terminal domain of DNA-binding protein Fis. The Factor for Inversion Stimulation (FIS) protein is a regulator of bacterial functions, and binds specifically to weakly related DNA sequences [ ]. It activates ribosomal RNA transcription, and is involved in upstream activation of rRNA promoters... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27465"
] | [
"Fis_N"
] | [
3322
] | 1 | [] | [] | [] | 0 | [
"1etk",
"1eto",
"1etq",
"1etv",
"1etw",
"1etx",
"1ety",
"1f36",
"1fia",
"1fip",
"3fis",
"3iv5",
"3jr9",
"3jra",
"3jrb",
"3jrc",
"3jrd",
"3jre",
"3jrf",
"3jrg",
"3jrh",
"3jri",
"4fis",
"4ihv",
"4ihw",
"4ihx",
"4ihy",
"5ds9",
"5dtd",
"5e3l",
"5e3m",
"5e3n"... | 37 | [
"PUB00007180",
"PUB00007181",
"PUB00007182",
"PUB00007183"
] | [
"7536730",
"11123690",
"11532124",
"9738943"
] | [
"Sequence, regulation, and functions of fis in Salmonella typhimurium.",
"Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression.",
"Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli.",... | [
1995,
2001,
2001,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
3297,
4,
21
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA-binding protein Fis, N-terminal domain | DNA-binding protein Fis, N-terminal domain | Fis_N | 2 |
IPR060480 | 60,480 | DLEC1, helical domain | DLEC1_helical | Domain | 822 | false | false | This entry represents a helical domain found in DLEC1 (Deleted in lung and esophageal cancer protein 1) and related proteins. DLEC1 is a large protein essential for spermatogenesis and male fertility, playing important roles in sperm head and tail formation [ ]. The full-length protein acts as a tumour suppressor by in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28484"
] | [
"DLEC1_helical"
] | [
822
] | 1 | [] | [] | [] | 0 | [
"9ijj"
] | 1 | [
"PUB00034974",
"PUB00155671"
] | [
"10213508",
"33144677"
] | [
"Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3.",
"Dlec1 is required for spermatogenesis and male fertility in mice."
] | [
1999,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
822
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
6,
4,
7
] | 4 | true | Domain | DLEC1, helical domain | DLEC1, helical domain | DLEC1_helical | 4 |
IPR060483 | 60,483 | WIP, coiled-coil domain | WIP_coiled_coil | Domain | 999 | false | false | This entry represents a coiled-coil domain found towards the C-terminal of WPP domain-interacting proteins (WIP). The coiled-coil domains facilitate protein-protein interactions and homodimer or heterodimer formation between WIP family members. This entry represents the WPP domain-interacting protein (WIP) family which... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28487"
] | [
"WIP_coiled_coil"
] | [
999
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090377",
"PUB00090379",
"PUB00096857"
] | [
"18591351",
"25759303",
"17600715"
] | [
"Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP.",
"Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.",
"Anchorage of plant RanGAP to the n... | [
2008,
2015,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
999
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
10,
19
] | 3 | true | Domain | WIP, coiled-coil domain | WIP, coiled-coil domain | WIP_coiled_coil | 3 |
IPR060484 | 60,484 | CLU5d, C-terminal domain | CLU5d_C | Domain | 1,880 | false | false | This entry represents the C-terminal domain of pathogenicity cluster 5 protein d (CLU5d) found in plant pathogenic fungi. This C-terminal domain follows the central region of the protein and is found in CLU5d homologues across Colletotrichum species and related plant pathogens. The specific function of this C-terminal ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27672"
] | [
"CLU5d_C"
] | [
1880
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161879"
] | [
"31599055"
] | [
"Two genes in a pathogenicity gene cluster encoding secreted proteins are required for appressorial penetration and infection of the maize anthracnose fungus Colletotrichum graminicola."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1880
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | CLU5d, C-terminal domain | CLU5d, C-terminal domain | CLU5d_C | 1 |
IPR060485 | 60,485 | Effector TSP1 | TSP1 | Domain | 1,437 | false | false | This entry represents a meander β-barrel domain found in TSP1 effector proteins and related small secreted cysteine-rich proteins. The domain is found in fungi, particularly within the Hypocreales. The structure consists of alternating stacked layers of tryptophan and arginine residues from respective strands, stabilis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27986"
] | [
"TSP1"
] | [
1437
] | 1 | [] | [] | [] | 0 | [
"7cwj",
"7cwp",
"7esw"
] | 3 | [
"PUB00162355"
] | [
"34547313"
] | [
"Structure-function analysis reveals Trichoderma virens Tsp1 to be a novel fungal effector protein modulating plant defence."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1437
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Effector TSP1 | Effector TSP1 | TSP1 | 5 |
IPR060486 | 60,486 | HYOU1-like, C-terminal domain | HYOU1_C | Domain | 10,679 | false | false | This domain is found at the C-terminal end of human Hypoxia up-regulated protein 1 (HYOU1). This domain also covers the C-terminal in Heat shock proteins such as Heat shock protein 105 kDa, Heat shock 70 kDa protein 4 and Heat shock 70 kDa protein 14. This domain may adopt a tri-helical bundle fold. HYOU1 has a pivotal... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27508"
] | [
"HYOU1_C"
] | [
10679
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3371453",
"R-CEL-3371453",
"R-HSA-3000484",
"R-HSA-3371453",
"R-HSA-381038",
"R-MMU-3371453",
"R-RNO-3371453"
] | [
"REACTOME:R-BTA-3371453",
"REACTOME:R-CEL-3371453",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3371453",
"REACTOME:R-HSA-381038",
"REACTOME:R-MMU-3371453",
"REACTOME:R-RNO-3371453"
] | 7 | [] | 0 | [
"PUB00087480",
"PUB00127220",
"PUB00156877",
"PUB00162043",
"PUB00162044"
] | [
"24318877",
"10037731",
"30710085",
"14644449",
"15292236"
] | [
"Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.",
"150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death.",
"MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.",
... | [
2014,
1999,
2019,
2003,
2004
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10679
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
3,
8,
4,
34,
10,
1,
7,
14,
56
] | 10 | true | Domain | HYOU1-like, C-terminal domain | HYOU1-like, C-terminal domain | HYOU1_C | 8 |
IPR060487 | 60,487 | Spore killer, N-terminal domain | SPOK_N | Domain | 2,721 | false | false | This entry represents the N-terminal domain of spore killer 1/2/3/4 (SPOK1,2,3,4) proteins, found in ascomycete fungi. The N-terminal region contains a coiled-coil domain and disordered regions. The specific function of this N-terminal domain remains to be determined. SPOK1, SPOK3 and SPOK4 promotes unequal transmissio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27653"
] | [
"SPOK2_N"
] | [
2721
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162303",
"PUB00162304"
] | [
"24830502",
"31347500"
] | [
"Genes that bias Mendelian segregation.",
"Combinations of <i>Spok</i> genes create multiple meiotic drivers in <i>Podospora</i>."
] | [
2014,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2721
] | 1 | [] | [] | 0 | true | Domain | Spore killer, N-terminal domain | Spore killer, N-terminal domain | SPOK_N | 7 |
IPR060488 | 60,488 | Pectate-lyase like, beta-helix domain | Beta_helix_4 | Domain | 5,538 | false | false | This entry represents β-helix domains primarily found in Pseudomonadati species of bacteria. Proteins usually contain at least two copies of this domain, but some have as many as five copies and some others only one. These proteins often contain an N-terminal lipoprotein attachment motif suggesting they are anchored to... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28492"
] | [
"Beta_helix_4"
] | [
5538
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
5365,
114,
11,
48
] | 4 | [] | [] | 0 | true | Domain | Pectate-lyase like, beta-helix domain | Pectate-lyase like, beta-helix domain | Beta_helix_4 | 3 |
IPR060489 | 60,489 | PMEPA1-like, helical domain | PMEPA1-like_helical | Domain | 2,334 | false | false | This entry represents the cytoplasmic helical domain found in PMEPA1 (prostate transmembrane protein androgen induced 1) and related proteins mainly found in vertebrates, including human LDLRAD4 (Low-density lipoprotein receptor class A domain-containing protein 4). PMEPA1 functions as a negative regulator of TGF-beta ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27646"
] | [
"PMEPA1_helical"
] | [
2334
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-2173788",
"R-MMU-2173788"
] | [
"REACTOME:R-HSA-2173788",
"REACTOME:R-MMU-2173788"
] | 2 | [] | 0 | [
"PUB00088947",
"PUB00094031",
"PUB00162259"
] | [
"20129061",
"24627487",
"18703514"
] | [
"TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.",
"C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.",
"A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate canc... | [
2010,
2014,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2334
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
13,
8,
6
] | 4 | true | Domain | PMEPA1-like, helical domain | PMEPA1-like, helical domain | PMEPA1-like_helical | 6 |
IPR060490 | 60,490 | Heat shock protein 15, C-terminal domain | HSP15_C | Domain | 6,302 | false | false | This entry represents the C-terminal domain of heat shock protein 15 (HSP15). This C-terminal domain follows the S4 RNA-binding domain ( ) and is predicted to have small helical segments with basic and acidic residue composition. The exact role of this C-terminal region in ribosomal subunit binding remains to be determ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28601"
] | [
"HSP15_C"
] | [
6302
] | 1 | [] | [] | [] | 0 | [
"1dm9",
"5z81",
"8ap4"
] | 3 | [
"PUB00057907",
"PUB00057908"
] | [
"10675343",
"9867837"
] | [
"Hsp15: a ribosome-associated heat shock protein.",
"A new heat shock protein that binds nucleic acids."
] | [
2000,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6231,
6,
65
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Heat shock protein 15, C-terminal domain | Heat shock protein 15, C-terminal domain | HSP15_C | 4 |
IPR060491 | 60,491 | NADPH-dependent oxidoreductase NFRA-like, C-terminal domain | NFRA-like_C | Domain | 7,743 | false | false | This entry represents the C-terminal domain in oxygen-insensitive nitroreductase enzymes. This C-terminal domain follows the main nitroreductase domain ( ) and contains residues important for NADPH binding and catalytic activity, including a conserved arginine residue that, when mutated to alanine, causes a strong decr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28600"
] | [
"Nitroreductase_C"
] | [
7743
] | 1 | [] | [] | [] | 0 | [
"1bkj",
"1f5v",
"1zch",
"2bkj",
"3n2s",
"5hdj",
"5hei",
"5uu6",
"7nb9",
"7niy",
"7nmp",
"7nnx",
"7q0o",
"7z0w",
"8ajx"
] | 15 | [
"PUB00021566",
"PUB00023654",
"PUB00070809",
"PUB00070810",
"PUB00070811"
] | [
"11034992",
"8885832",
"8755878",
"8206832",
"22650604"
] | [
"Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitution.",
"Flavin reductase P: structure of a dimeric enzyme that reduces flavin.",
"Biochemical characterization of NfsA, the Esch... | [
2001,
1996,
1996,
1994,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
7570,
135,
18,
20
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | NADPH-dependent oxidoreductase NFRA-like, C-terminal domain | NADPH-dependent oxidoreductase NFRA-like, C-terminal domain | NFRA-like_C | 4 |
IPR060492 | 60,492 | TMEM260-associated domain 2 | TMEM260_2 | Domain | 4,318 | false | false | This entry represents a conserved domain found in TMEM260 and related O-mannosyltransferases. In TMEM260, this domain spans approximately residues 421-479 in human and is located in the luminal portion of the protein, between the N-terminal transmembrane region ( ) and the C-terminal. While the specific function of thi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28495"
] | [
"TMEM260_2"
] | [
4318
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151531"
] | [
"37186866"
] | [
"The SHDRA syndrome-associated gene <i>TMEM260</i> encodes a protein-specific O-mannosyltransferase."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3582,
629,
107
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
5
] | 3 | true | Domain | TMEM260-associated domain 2 | TMEM260-associated domain 2 | TMEM260_2 | 4 |
IPR060493 | 60,493 | BICD family-like cargo adapter 1/2-like, C-terminal domain | BICDL1/2-like_C | Domain | 2,603 | false | false | This entry represents the C-terminal domain of BICD family-like cargo adapter 1/2 (BICDL1/2) proteins, mainly found in vertebrates and arthropods. BICDL1 is a cytoplasmic protein involved in Golgi to secretory granule transport and vesicle transport along microtubules. It contains extensive coiled-coil regions and func... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27654"
] | [
"BICDL2_C"
] | [
2603
] | 1 | [] | [] | [] | 0 | [
"6f1u",
"7z8f",
"7z8i",
"7z8j",
"7z8k",
"7z8m",
"9dgt",
"9dgu"
] | 8 | [
"PUB00156756",
"PUB00161829",
"PUB00161830",
"PUB00161831",
"PUB00161832"
] | [
"29420470",
"38264934",
"20360680",
"33734450",
"36071160"
] | [
"Cryo-EM shows how dynactin recruits two dyneins for faster movement.",
"Role of BicDR in bristle shaft construction and support of BicD functions.",
"Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.",
"Cryo-EM reveals the complex archite... | [
2018,
2024,
2010,
2021,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2603
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
2,
6,
7,
11
] | 5 | true | Domain | BICD family-like cargo adapter 1/2-like, C-terminal domain | BICD family-like cargo adapter 1/2-like, C-terminal domain | BICDL1/2-like_C | 1 |
IPR060494 | 60,494 | Nuclear envelope-associated protein, C-terminal | NEAP_C | Domain | 931 | false | false | This entry represents the C-terminal region of nuclear envelope-associated protein (NEAP) family of proteins from plants. These proteins are characterised by extensive coiled-coil domains and a C-terminal transmembrane region that anchors them to the nuclear inner membrane. This entry covers part of the coiled-coil and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28496"
] | [
"NEAP"
] | [
931
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088445"
] | [
"27630107"
] | [
"A novel family of plant nuclear envelope-associated proteins."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
931
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
3,
30
] | 3 | true | Domain | Nuclear envelope-associated protein, C-terminal | Nuclear envelope-associated protein, C-terminal | NEAP_C | 3 |
IPR060495 | 60,495 | Pyruvate dehydrogenase E1 component, N-terminal domain | PDH_E1_N | Domain | 14,190 | false | false | This entry represents a small hairpin region found at the N-terminal of pyruvate dehydrogenase E1 component (AceE). The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. The E1 component is a thiamine diphosphate-dependent enzyme that catalyses the decarboxyla... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28598"
] | [
"PDH_E1_N"
] | [
14190
] | 1 | [
"EC"
] | [
"1.2.4.1"
] | [
"EC:1.2.4.1"
] | 1 | [
"1l8a",
"1rp7",
"2g25",
"2g28",
"2g67",
"2iea",
"2qta",
"2qtc",
"3lpl",
"3lq2",
"3lq4",
"4qoy",
"9h1n"
] | 13 | [
"PUB00162220",
"PUB00162221"
] | [
"16045627",
"20675489"
] | [
"Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.",
"The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF."
] | [
2005,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Sym plasmid",
"unclassified sequences"
] | [
13835,
41,
19,
1,
294
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Pyruvate dehydrogenase E1 component, N-terminal domain | Pyruvate dehydrogenase E1 component, N-terminal domain | PDH_E1_N | 2 |
IPR060496 | 60,496 | Penicillin-binding protein-like, middle domain | PBP-like_middle | Domain | 3,809 | false | false | This entry represents a conserved domain found in penicillin-binding proteins (PBPs) from Bacteroidota bacteria, particularly members of Flavobacteriaceae and Sphingobacteriaceae. The domain spans approximately 75-80 residues and is positioned between the N-terminal transglycosylase domain ( ) and the C-terminal transp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28500"
] | [
"PBP_middle"
] | [
3809
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3750,
4,
55
] | 3 | [] | [] | 0 | true | Domain | Penicillin-binding protein-like, middle domain | Penicillin-binding protein-like, middle domain | PBP-like_middle | 1 |
IPR060498 | 60,498 | Tail fiber assembly protein, N-terminal domain | Caudo_TAP_N | Domain | 3,014 | false | false | This entry represents the N-terminal domain of tail fibre assembly proteins found in bacteriophages and prophage regions. These chaperone proteins act in the assembly of long tail fibres [ , ]. The tail fibre assembly protein is necessary for the maturation of the tail fibre structural subunit to its dimeric form [ ]. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28596"
] | [
"Caudo_TAP_N"
] | [
3014
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015588",
"PUB00161849",
"PUB00161850"
] | [
"8892827",
"2960666",
"8057378"
] | [
"Characterization of the helper proteins for the assembly of tail fibers of coliphages T4 and lambda.",
"An open reading frame in the Escherichia coli bacteriophage lambda genome encodes a protein that functions in assembly of the long tail fibers of bacteriophage T4.",
"Determinants of receptor specificity of ... | [
1996,
1987,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Opisthokonta",
"metagenomes"
] | [
2904,
101,
6,
3
] | 4 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
3,
1
] | 2 | true | Domain | Tail fiber assembly protein, N-terminal domain | Tail fiber assembly protein, N-terminal domain | Caudo_TAP_N | 2 |
IPR060499 | 60,499 | Putative lipoprotein RzoQ | RzoQ | Domain | 87 | false | false | This entry represents the putative lipoprotein RzoQ found in Escherichia coli. This small protein of 84 amino acids is predicted to be a lipoprotein localised to the cell membrane via an N-terminal lipid anchor. The gene rzoQ is entirely encoded within the coding sequence of rzpQ ( ) on the same strand but in a differe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28595"
] | [
"RzoQ"
] | [
87
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"plant metagenome"
] | [
70,
15,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Putative lipoprotein RzoQ | Putative lipoprotein RzoQ | RzoQ | 8 |
IPR060500 | 60,500 | Uncharacterized protein YdgU | YdgU | Family | 133 | false | false | This entry represents YdgU, a small protein of 27 amino acids found in Escherichia coli and related bacteria. YdgU was identified through a computational search for genes preceded by strong ribosome binding sites, specifically a canonical Shine-Dalgarno sequence (GGAGGG in this case) [ ]. The protein is expressed speci... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28593"
] | [
"YdgU"
] | [
133
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104946"
] | [
"19121005"
] | [
"Small membrane proteins found by comparative genomics and ribosome binding site models."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
133
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Uncharacterized protein YdgU | Uncharacterized protein YdgU | YdgU | 5 |
IPR060501 | 60,501 | ENDOD1 C-terminal coiled-coil domain | ENDOD1_C | Domain | 599 | false | false | This entry represents the C-terminal coiled-coil domain of the ENDOD1 (endonuclease domain-containing 1) protein family. This C-terminal domain forms a coiled-coil structure that may be important for protein-protein interactions or structural stability. The specific function of this C-terminal coiled coil domain within... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28501"
] | [
"ENDOD1_C"
] | [
599
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-114608",
"R-MMU-114608"
] | [
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608"
] | 2 | [] | 0 | [
"PUB00088746",
"PUB00088747",
"PUB00162524"
] | [
"28532481",
"26784919",
"32614325"
] | [
"Identification of endonuclease domain-containing 1 as a novel tumor suppressor in prostate cancer.",
"Identification of endonuclease domain-containing 1 gene in Japanese flounder Paralichthys olivaceus.",
"Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune sig... | [
2017,
2016,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes",
"Euteleostomi"
] | [
14,
4,
581
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2
] | 3 | true | Domain | ENDOD1 C-terminal coiled-coil domain | ENDOD1 C-terminal coiled-coil domain | ENDOD1_C | 6 |
IPR060502 | 60,502 | GH172, middle domain | GH172_mid | Domain | 2,923 | false | false | This domain is found the middle region of members of GH172 family. These proteins contain three homologous domains which are structurally very similar and adopt a jelly-roll β-sandwich. Some of these proteins are structurally characterised such as DFA I synthase/hydrolase from Bifidobacterium dentium and Exo-alpha-D-ar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28589"
] | [
"GH172_dom"
] | [
2923
] | 1 | [] | [] | [] | 0 | [
"4kq7",
"7v1v",
"7v1w",
"7v1x",
"8ah3",
"8ic8"
] | 6 | [
"PUB00161976",
"PUB00161977",
"PUB00161978"
] | [
"37076525",
"37726269",
"34688653"
] | [
"Identification of D-arabinan-degrading enzymes in mycobacteria.",
"Identification and characterization of endo-α-, exo-α-, and exo-β-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria.",
"Identification of difructose dianhydride I synthase/hydrolase from an oral bacterium es... | [
2023,
2023,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
13,
2619,
250,
41
] | 4 | [] | [] | 0 | true | Domain | GH172, middle domain | GH172, middle domain | GH172_mid | 4 |
IPR060503 | 60,503 | PAB, middle domain | PAB_middle | Domain | 924 | false | false | This entry represents the middle domain of the PAB (protein IN CHLOROPLAST ATPASE BIOGENESIS), whose function is not yet clear. It may contribute to the structural organisation of the PAB protein. This entry includes a group of plant proteins, including PAB (Protein IN CHLOROPLAST ATPASE BIOGENESIS) from Arabidopsis. P... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28502"
] | [
"PAB_middle"
] | [
924
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098475"
] | [
"25775508"
] | [
"PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
924
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
3,
6
] | 3 | true | Domain | PAB, middle domain | PAB, middle domain | PAB_middle | 9 |
IPR060504 | 60,504 | GH172, first beta-sandwich domain | GH172_1st | Domain | 1,629 | false | false | This entry represents a domain found in GH172 family of enzymes [ , , ]. These proteins contain a pair of homologous structurally similar domains which adopt jelly-roll β-sandwich. They assemble into a trimeric structure that can form other higher-order assemblies. This domain is usually associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28588"
] | [
"GH172_1st"
] | [
1629
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161976",
"PUB00161977",
"PUB00161978"
] | [
"37076525",
"37726269",
"34688653"
] | [
"Identification of D-arabinan-degrading enzymes in mycobacteria.",
"Identification and characterization of endo-α-, exo-α-, and exo-β-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria.",
"Identification of difructose dianhydride I synthase/hydrolase from an oral bacterium es... | [
2023,
2023,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"metagenomes"
] | [
1478,
1,
125,
25
] | 4 | [] | [] | 0 | true | Domain | GH172, first beta-sandwich domain | GH172, first beta-sandwich domain | GH172_1st | 2 |
IPR060506 | 60,506 | CPR5, C-terminal domain | CPR5_C | Domain | 870 | false | false | This entry represents the C-terminal domain of protein CPR5 (constitutive expression of pathogenesis-related genes 5), a negative regulator of plant programmed cell death and effector-triggered immunity. The domain spans approximately 72 residues and follows the transmembrane regions of the protein. While the full-leng... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28583"
] | [
"CPR5_C"
] | [
870
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096878",
"PUB00096879",
"PUB00096880",
"PUB00096881",
"PUB00096882",
"PUB00096883",
"PUB00096884"
] | [
"11728314",
"11846876",
"25455564",
"21875893",
"9338960",
"32600419",
"31692196"
] | [
"CPR5 is involved in cell proliferation and cell death control and encodes a novel transmembrane protein.",
"Identification of a novel gene HYS1/CPR5 that has a repressive role in the induction of leaf senescence and pathogen-defence responses in Arabidopsis thaliana.",
"A noncanonical role for the CKI-RB-E2F c... | [
2001,
2002,
2014,
2011,
1997,
2020,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
870
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
43,
9,
11
] | 3 | true | Domain | CPR5, C-terminal domain | CPR5, C-terminal domain | CPR5_C | 7 |
IPR060507 | 60,507 | Meiosis inhibitor protein 1, N-terminal domain | MEI1_N | Domain | 887 | false | false | This entry represents the N-terminal domain of meiosis inhibitor protein 1 (MEI1), a vertebrate-specific protein required for normal meiotic chromosome synapsis. This domain is absent in some alternative splice isoforms. While the full-length MEI1 protein functions in meiotic chromosome synapsis and double-strand break... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28582"
] | [
"MEI1_N"
] | [
887
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162153",
"PUB00162154"
] | [
"14668445",
"16683055"
] | [
"Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.",
"Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest."
] | [
2003,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
887
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
4,
3,
3
] | 4 | true | Domain | Meiosis inhibitor protein 1, N-terminal domain | Meiosis inhibitor protein 1, N-terminal domain | MEI1_N | 5 |
IPR060510 | 60,510 | ATA15/OSA15, coiled-coil domain | ATA15/OSA15_CC | Domain | 718 | false | false | This entry represents a coiled-coil domain found in senescence-associated proteins of the ATA15/OSA15 family from plants including SPA15, OSA15 and AAF. The domain spans approximately 89 residues and is located in the middle region of these chloroplast-localised proteins. The N-terminal is disordered. While the full-le... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28580"
] | [
"OSA15_N"
] | [
718
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097648",
"PUB00097650"
] | [
"12650614",
"21940719"
] | [
"Molecular characterization of a novel senescence-associated gene SPA15 induced during leaf senescence in sweet potato.",
"Role of ARABIDOPSIS A-FIFTEEN in regulating leaf senescence involves response to reactive oxygen species and is dependent on ETHYLENE INSENSITIVE2."
] | [
2003,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
718
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
2,
3
] | 3 | true | Domain | ATA15/OSA15, coiled-coil domain | ATA15/OSA15, coiled-coil domain | ATA15/OSA15_CC | 7 |
IPR060511 | 60,511 | Large ribosomal subunit protein cL37, C-terminal domain | PSRP5_C | Domain | 712 | false | false | This entry represents the C-terminal domain of large ribosomal subunit protein cL37 (PSRP5). The domain spans approximately 54 residues and is located after a disordered region in the protein sequence. While the full-length cL37 protein functions in plastid translation, the specific function of this C-terminal domain r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28578"
] | [
"PSRP5_C"
] | [
712
] | 1 | [] | [] | [] | 0 | [
"5h1s",
"5mlc",
"5mmi",
"5mmm",
"5x8p",
"5x8t",
"6eri"
] | 7 | [
"PUB00046123",
"PUB00148890",
"PUB00158258",
"PUB00158259"
] | [
"10874046",
"28007896",
"27986857",
"27762343"
] | [
"The plastid ribosomal proteins. Identification of all the proteins in the 50 S subunit of an organelle ribosome (chloroplast).",
"The complete structure of the chloroplast 70S ribosome in complex with translation factor pY.",
"Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plasti... | [
2000,
2017,
2017,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
712
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
2,
9
] | 3 | true | Domain | Large ribosomal subunit protein cL37, C-terminal domain | Large ribosomal subunit protein cL37, C-terminal domain | PSRP5_C | 4 |
IPR060512 | 60,512 | At5g58720/SDE5-like, middle domain | At5g58720/SDE5-like_middle | Domain | 1,534 | false | false | This domain is found in the middle region of putative nuclear RNA export factor SDE5, SMR domain-containing protein At5g58720 from Arabidopsis thaliana and related sequences. SDE5 is involved in sense transgene post-transcriptional gene silencing (S-PTGS) and is an essential component of the trans-acting short interfer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28508"
] | [
"UBA_SDE5"
] | [
1534
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155897",
"PUB00162363",
"PUB00162525"
] | [
"17397509",
"20798330",
"34408020"
] | [
"SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA.",
"The conserved RNA trafficking proteins HPR1 and TEX1 are involved in the production of endogenous and exogenous small interfering RNA in Arabidopsis.",
"Cooperat... | [
2007,
2010,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1534
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
5,
25
] | 3 | true | Domain | At5g58720/SDE5-like, middle domain | At5g58720/SDE5-like, middle domain | At5g58720/SDE5-like_middle | 1 |
IPR060513 | 60,513 | O-fucosyltransferase 5/14/36, N-terminal helical domain | OFUT-14-like_helical_N | Domain | 812 | false | false | This entry represents the N-terminal helical domain found in O-fucosyltransferase 5, 14 and 36 proteins in plants. This N-terminal helical domain precedes the catalytic glycosyltransferase domain and includes the transmembrane region and adjacent sequences. The domain is found in land plants (Embryophyta), particularly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28573"
] | [
"OFUT_helical_N"
] | [
812
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [] | 0 | [
"PUB00162212",
"PUB00162213"
] | [
"24905498",
"23272088"
] | [
"The plant glycosyltransferase clone collection for functional genomics.",
"Identification of putative rhamnogalacturonan-II specific glycosyltransferases in Arabidopsis using a combination of bioinformatics approaches."
] | [
2014,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Euphyllophyta"
] | [
812
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
2,
2
] | 3 | true | Domain | O-fucosyltransferase 5/14/36, N-terminal helical domain | O-fucosyltransferase 5/14/36, N-terminal helical domain | OFUT-14-like_helical_N | 3 |
IPR060515 | 60,515 | GIGANTEA, C-terminal domain | GIGANTEA_C | Domain | 1,312 | false | false | This entry represents the C-terminal domain of GIGANTEA proteins found in plants. The full-length GIGANTEA protein is involved in regulation of circadian rhythm and photoperiodic flowering [ , ]. GIGANTEA belongs to a distinct protein family and is localised to both the nucleus and cytoplasm [ ]. The protein stabilises... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28518"
] | [
"GIGANTEA_C"
] | [
1312
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060224",
"PUB00060786",
"PUB00161979"
] | [
"10920210",
"10469647",
"17704763"
] | [
"GIGANTEA is a nuclear protein involved in phytochrome signaling in Arabidopsis.",
"GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic flowering in Arabidopsis and encodes a protein with several possible membrane-spanning domains.",
"ZEITLUPE is a circadian photoreceptor stabilized by GIGA... | [
2000,
1999,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1312
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
2,
89
] | 3 | true | Domain | GIGANTEA, C-terminal domain | GIGANTEA, C-terminal domain | GIGANTEA_C | 3 |
IPR060517 | 60,517 | CCDC162, middle domain | CCDC162_mid | Domain | 669 | false | false | This entry represents the middle domain of CCDC162 (Coiled-coil domain-containing protein 162), found in vertebrates. CCDC162 is a protein characterised by the presence of multiple coiled-coil regions, including predicted coiled-coil domains at the N-terminal region and in the middle portion of the protein. The protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28523"
] | [
"CCDC162_mid"
] | [
669
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
669
] | 1 | [
"Danio rerio",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3
] | 3 | true | Domain | CCDC162, middle domain | CCDC162, middle domain | CCDC162_mid | 9 |
IPR060518 | 60,518 | At4g04980, N-terminal domain | At4g04980_N | Domain | 799 | false | false | This entry represents the N-terminal domain of At4g04980 and related proteins found in plants. This N-terminal domain precedes the coiled coil and disordered regions found in the central portion of the protein. The domain is found predominantly in land plants (Embryophyta), particularly within the rosids. The function ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28571"
] | [
"At4g04980_N"
] | [
799
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Euphyllophyta"
] | [
799
] | 1 | [
"Arabidopsis thaliana",
"Zea mays"
] | [
24,
7
] | 2 | true | Domain | At4g04980, N-terminal domain | At4g04980, N-terminal domain | At4g04980_N | 5 |
IPR060519 | 60,519 | IL27RA, third fibronectin type-III domain | IL27RA_FN3_3 | Domain | 629 | false | false | This entry represents the third fibronectin type-III domain of interleukin-27 receptor subunit alpha (IL27RA) and related cytokine receptors found in vertebrates. The protein contains multiple fibronectin type-III domains in its extracellular region. The specific function of this individual domain remains to be determi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28570"
] | [
"IL27RA_FN3_3"
] | [
629
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8984722",
"R-HSA-9020956",
"R-MMU-8984722",
"R-MMU-9020956"
] | [
"REACTOME:R-HSA-8984722",
"REACTOME:R-HSA-9020956",
"REACTOME:R-MMU-8984722",
"REACTOME:R-MMU-9020956"
] | 4 | [
"8d85"
] | 1 | [
"PUB00162099",
"PUB00162100"
] | [
"9600072",
"14764690"
] | [
"Cloning and characterization of a novel class I cytokine receptor.",
"WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."
] | [
1998,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
629
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2
] | 3 | true | Domain | IL27RA, third fibronectin type-III domain | IL27RA, third fibronectin type-III domain | IL27RA_FN3_3 | 4 |
IPR060523 | 60,523 | Maltose excess protein 1, N-terminal domain | MEX1_N | Domain | 829 | false | false | This entry represents the N-terminal domain of maltose excess protein 1 (MEX1). The protein is found in plants and contains a chloroplast transit peptide for targeting to the plastid. The specific function of this N-terminal domain remains to be determined. MEX1 is a maltose transporter essential for the conversion of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28566"
] | [
"MEX1_N"
] | [
829
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083799",
"PUB00162155",
"PUB00162156"
] | [
"21175634",
"14704427",
"10536027"
] | [
"Role of the plastidic glucose translocator in the export of starch degradation products from the chloroplasts in Arabidopsis thaliana.",
"A previously unknown maltose transporter essential for starch degradation in leaves.",
"Genetic ablation of root cap cells in Arabidopsis."
] | [
2011,
2004,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
829
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
7,
5
] | 3 | true | Domain | Maltose excess protein 1, N-terminal domain | Maltose excess protein 1, N-terminal domain | MEX1_N | 2 |
IPR060524 | 60,524 | McrB, alpha-helical lid domain | McrB_lid | Domain | 4,752 | false | false | This domain is found in McrB component of McrBC complex from Escherichia coli and related bacterial proteins. McrBC system is a motor driven nuclease functioning in bacterial self-defence. McrB is a GTP-specific AAA+ protein that powers the translocation along DNA [ ]. This domain is inserted into the AAA-like domain. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28529"
] | [
"McrB_lid"
] | [
4752
] | 1 | [] | [] | [] | 0 | [
"6hz4",
"6hz5",
"6hz6",
"6hz7",
"6hz8",
"6hz9",
"6ut3",
"6ut4",
"6ut5",
"6ut6",
"6ut7",
"6ut8",
"7vsr"
] | 13 | [
"PUB00162150"
] | [
"33219217"
] | [
"Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. cte421",
"unclassified sequences"
] | [
145,
4547,
3,
1,
56
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | McrB, alpha-helical lid domain | McrB, alpha-helical lid domain | McrB_lid | 7 |
IPR060525 | 60,525 | ART2/RRT15-like domain | ART2/RRT15-like_dom | Domain | 4,949 | false | false | This entry represents a domain found in the regulator of rDNA transcription protein 15 (RRT15), and similar proteins from eukaryotes. RRT15 proteins are small proteins of approximately 60 amino acids that are involved in modulation of ribosomal DNA transcription [ ]. These proteins play a role in transcriptional regula... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27657"
] | [
"RRT15"
] | [
4949
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075791"
] | [
"19270272"
] | [
"Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group"
] | [
4,
4943,
2
] | 3 | [
"Arabidopsis thaliana",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
1,
2,
1
] | 3 | true | Domain | ART2/RRT15-like domain | ART2/RRT15-like domain | ART2/RRT15-like_dom | 8 |
IPR060526 | 60,526 | Centromere protein C, C-terminal domain | CENPC_C | Domain | 855 | false | false | This entry represents the C-terminal domain of centromere protein C (CENP-C) from plants. This C-terminal region contains the MIF2 homology domain II, which targets centromeres and binds centromeric DNA. The specific function of this C-terminal domain is centromeric DNA binding and centromere targeting. CENP-C is a com... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28563"
] | [
"CENPC_C"
] | [
855
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161866",
"PUB00161867"
] | [
"15329494",
"15161939"
] | [
"Characterization of a CENP-C homolog in Arabidopsis thaliana.",
"Differential localization of the centromere-specific proteins in the major centromeric satellite of Arabidopsis thaliana."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
855
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
5,
17
] | 3 | true | Domain | Centromere protein C, C-terminal domain | Centromere protein C, C-terminal domain | CENPC_C | 1 |
IPR060527 | 60,527 | Myomegalin-like, C-terminal | Pde4dip-like_C | Domain | 3,691 | false | false | This domain is found towards the C-terminal end of human Myomegalin (PDE4DIP) and CDK5RAP2, and similar animal sequences. This domain is predicted to adopt an all-α configuration. PDE4DIP functions as an anchor sequestering component of the cAMP-dependent pathway to Golgi and/or centrosomes [ ]. It may participate in m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26710"
] | [
"Pde4dip"
] | [
3691
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [
"6x0v",
"9g3y",
"9g3z",
"9g40",
"9h9p",
"9qvm"
] | 6 | [
"PUB00075362",
"PUB00075363",
"PUB00093344",
"PUB00156007",
"PUB00156008",
"PUB00156009",
"PUB00162216",
"PUB00162217",
"PUB00162218",
"PUB00162219",
"PUB00162526"
] | [
"11134006",
"18042621",
"17959831",
"25217626",
"27666745",
"28814570",
"20627074",
"20460369",
"20471352",
"19282672",
"15164053"
] | [
"Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase.",
"Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion.",
"CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex.",
"A newly ... | [
2001,
2007,
2008,
2014,
2016,
2017,
2010,
2010,
2010,
2009,
2004
] | 11 | [] | [] | 0 | 0 | null | [
"Clostridium",
"Eumetazoa"
] | [
4,
3687
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
144,
27,
8,
26
] | 4 | true | Domain | Myomegalin-like, C-terminal | Myomegalin-like, C-terminal | Pde4dip-like_C | 9 |
IPR060528 | 60,528 | Trigger factor, FKBP-like domain | FKBP-like_TF | Domain | 2,301 | false | false | This domain is found in tigger factor proteins from Chlorobiaceae and related proteins from Bacteroidetes. They are involved in protein export. This entry share similarity to FKBP-like domain and is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28537"
] | [
"FKBP-like_TF"
] | [
2301
] | 1 | [
"EC"
] | [
"5.2.1.8"
] | [
"EC:5.2.1.8"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2253,
3,
45
] | 3 | [] | [] | 0 | true | Domain | Trigger factor, FKBP-like domain | Trigger factor, FKBP-like domain | FKBP-like_TF | 3 |
IPR060529 | 60,529 | Protein downstream neighbor of Son domain | DONSON_dom | Domain | 2,928 | false | false | This entry represents a domain found in Downstream neighbor of Son (DONSON), a replisome component that maintains genome stability by protecting stalled or damaged replication forks [ ]. DONSON is required for stabilisation of stalled replication forks, efficient activation of intra-S-phase and G2/M cell-cycle checkpoi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27662"
] | [
"DONSON"
] | [
2928
] | 1 | [] | [] | [] | 0 | [
"8ouw",
"8q6o",
"8q6p"
] | 3 | [
"PUB00161909"
] | [
"28191891"
] | [
"Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2927,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
5,
1,
2,
10,
10,
3,
6,
5
] | 9 | true | Domain | Protein downstream neighbor of Son domain | Protein downstream neighbor of Son domain | DONSON_dom | 3 |
IPR060530 | 60,530 | Probable ATP-dependent RNA helicase, helical domain | Helicase_helical | Domain | 2,352 | false | false | This domain is found in uncharacterised bacterial proteins which share a global similarity to known ATP-dependent RNA helicases and are likely to perform similar function. It is predicted to fold into non-compact α-helical structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28538"
] | [
"Helicase_helical"
] | [
2352
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Protostomia",
"metagenomes"
] | [
2300,
4,
48
] | 3 | [] | [] | 0 | true | Domain | Probable ATP-dependent RNA helicase, helical domain | Probable ATP-dependent RNA helicase, helical domain | Helicase_helical | 6 |
IPR060531 | 60,531 | Probable trigger factor, C-terminal domain | TF_C | Domain | 2,497 | false | false | This domain is found in uncharacterised bacterial proteins which share global similarity to known trigger factors and are likely to perform similar function. This entry share similarity to their C-terminal domain and is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28539"
] | [
"TF_C"
] | [
2497
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Marine Group I thaumarchaeote",
"Protostomia",
"metagenomes"
] | [
2443,
1,
3,
50
] | 4 | [] | [] | 0 | true | Domain | Probable trigger factor, C-terminal domain | Probable trigger factor, C-terminal domain | TF_C | 8 |
IPR060532 | 60,532 | Ubiquitin-associated protein 2, UBA domain | UBA_UBAP2 | Domain | 4,720 | false | false | This ubiquitin-associated (UBA) domain is found at the N-terminal of human Ubiquitin-associated protein 2 (UBAP2) and similar proteins. UBAP2 recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) mac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28540"
] | [
"UBA_UBAP2"
] | [
4720
] | 1 | [] | [] | [] | 0 | [
"1wj7"
] | 1 | [
"PUB00094212",
"PUB00162364",
"PUB00162365",
"PUB00162366",
"PUB00162367"
] | [
"29395067",
"35633597",
"35977029",
"27121050",
"25185265"
] | [
"High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.",
"UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.",
"De novo variants in genes regulating stress granule assembly associate with neurode... | [
2018,
2022,
2022,
2016,
2014
] | 5 | [
"IPR015940"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4720
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
18,
11,
11
] | 4 | true | Domain | Ubiquitin-associated protein 2, UBA domain | Ubiquitin-associated protein 2, UBA domain | UBA_UBAP2 | 7 |
IPR060533 | 60,533 | YPL277C-like, N-terminal domain | YPL277C-like_N | Domain | 2,187 | false | false | This entry represents the N-terminal domain of YPL277C and other uncharacterised proteins in fungi such as YOR389W. YOR389W is an uncharacterised secreted glycoprotein from Saccharomyces cerevisiae that undergoes extensive N-linked glycosylation [ ]. The proteins contain signal peptides for secretion and multiple glyco... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27671"
] | [
"YPL277C_N"
] | [
2187
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162425"
] | [
"19756047"
] | [
"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2187
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2
] | 1 | true | Domain | YPL277C-like, N-terminal domain | YPL277C-like, N-terminal domain | YPL277C-like_N | 8 |
IPR060534 | 60,534 | SusR, N-terminal domain | SusR_N | Domain | 2,613 | false | false | This entry represents the N-terminal periplasmic domain of the SusR protein. This region of SusR is involved in sensing maltose levels and then transduces this signal to the C-terminal DNA-binding domain to promote transcription of the Sus operon [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28559"
] | [
"TPR_SusR"
] | [
2613
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056012",
"PUB00151613",
"PUB00162527"
] | [
"16735464",
"27137179",
"24330590"
] | [
"A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism.",
"The Sus operon: a model system for starch uptake by the human gut Bacteroidetes.",
"Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative ... | [
2006,
2016,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2554,
21,
38
] | 3 | [] | [] | 0 | true | Domain | SusR, N-terminal domain | SusR, N-terminal domain | SusR_N | 3 |
IPR060535 | 60,535 | Aq_493, helical needle domain | Aq_493_helical_needle | Domain | 2,988 | false | false | This domain is found in uncharacterised bacterial proteins including Uncharacterized protein aq_493 from Aquifex aeolicus. These proteins share a global similarity to MCE lipid transporter proteins and are likely to have similar function. This domain represents the helical needle region which assembles to form a tunnel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28544"
] | [
"Helical_needle"
] | [
2988
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2921,
4,
63
] | 3 | [] | [] | 0 | true | Domain | Aq_493, helical needle domain | Aq_493, helical needle domain | Aq_493_helical_needle | 8 |
IPR060536 | 60,536 | TonB, transmembrane helix | 1TM_TonB | Domain | 506 | false | false | This entry represents a single transmembrane helix found at the N-terminal of TonB proteins from Lysobacterales, which interacts with outer membrane receptor proteins carrying out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28546"
] | [
"1TM_TonB"
] | [
506
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lysobacterales"
] | [
4,
502
] | 2 | [] | [] | 0 | true | Domain | TonB, transmembrane helix | TonB, transmembrane helix | 1TM_TonB | 7 |
IPR060537 | 60,537 | YPL277C-like, C-terminal domain | YPL277C-like_C | Domain | 123 | false | false | This entry represents the C-terminal domain of YPL277C and other proteins found in ascomycetes such as YOR389W. YOR389W is an uncharacterised secreted glycoprotein from Saccharomyces cerevisiae that undergoes extensive N-linked glycosylation [ ]. The proteins contain signal peptides for secretion and multiple glycosyla... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27673"
] | [
"YPL277C_C"
] | [
123
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162425"
] | [
"19756047"
] | [
"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"saccharomyceta"
] | [
123
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2
] | 1 | true | Domain | YPL277C-like, C-terminal domain | YPL277C-like, C-terminal domain | YPL277C-like_C | 2 |
IPR060539 | 60,539 | OTUD7A/B, UBA domain | UBA_OTUD7A_B | Domain | 1,670 | false | false | This ubiquitin-associated (UBA) domain is found at the N-terminal of human OTU domain-containing protein 7A/B (OTUD7A/B) and related proteins. OTUD7A is a deubiquitinase that cleaves Lys-11-linked polyubiquitin chains and might be required for PA28-20S proteasome assembly [ , , , ]. OTUD7B is a negative regulator of th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28552"
] | [
"UBA_OTUD7A_B"
] | [
1670
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.19.12",
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
"R-HSA-5689896",
"R-MMU-5357786",
"R-MMU-5357905",
"R-MMU-5357956",
"R-MMU-5689896"
] | [
"EC:3.4.19.12",
"REACTOME:R-HSA-5357786",
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-5357956",
"REACTOME:R-HSA-5689896",
"REACTOME:R-MMU-5357786",
"REACTOME:R-MMU-5357905",
"REACTOME:R-MMU-5357956",
"REACTOME:R-MMU-5689896"
] | 9 | [
"2l2d"
] | 1 | [
"PUB00076543",
"PUB00150436",
"PUB00150438",
"PUB00150440",
"PUB00150481",
"PUB00162357",
"PUB00162358",
"PUB00162359",
"PUB00162360",
"PUB00162361"
] | [
"23827681",
"31997314",
"22179831",
"20622874",
"26903241",
"12682062",
"18178551",
"28489822",
"23334419",
"11463333"
] | [
"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.",
"Report of the first patient with a homozygous OTUD7A variant responsible for epileptic encephalopathy and related proteasome dysfunction.",
"Deubiquitination of EGFR by Cezanne-1 contributes to canc... | [
2013,
2020,
2012,
2010,
2016,
2003,
2008,
2017,
2013,
2001
] | 10 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1670
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
7,
5,
5
] | 4 | true | Domain | OTUD7A/B, UBA domain | OTUD7A/B, UBA domain | UBA_OTUD7A_B | 1 |
IPR060540 | 60,540 | tRNA(Ile)-lysidine synthase, SCL domain | TilS_SCL | Domain | 2,551 | false | false | This domain is found in tRNA(Ile)-lysidine synthase (TilS) from Bacteroidota only. TilS modifies cytidine into lysidine at the first anticodon of tRNA(Ile). This modification switches tRNA(Ile) from a methionine-specific to an isoleucine-specific tRNA. This domain is also known as the stem contact-like (SCL) domain bec... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28558"
] | [
"TilS_SCL"
] | [
2551
] | 1 | [
"EC"
] | [
"6.3.4.19"
] | [
"EC:6.3.4.19"
] | 1 | [] | 0 | [
"PUB00061249",
"PUB00156182"
] | [
"19847269",
"19233850"
] | [
"Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase.",
"The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase."
] | [
2009,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Protostomia",
"metagenomes"
] | [
2495,
3,
53
] | 3 | [] | [] | 0 | true | Domain | tRNA(Ile)-lysidine synthase, SCL domain | tRNA(Ile)-lysidine synthase, SCL domain | TilS_SCL | 6 |
IPR060541 | 60,541 | Probable helicase, winged helix domain | WH_1 | Domain | 4,743 | false | false | This winged helix HTH domain is found in uncharacterised bacterial proteins. Many of these proteins contain P-loop domains with the typical for helicase arrangement. This domain is often found N-terminal to these probable helicase domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28553"
] | [
"WH_1"
] | [
4743
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
4658,
23,
5,
57
] | 4 | [] | [] | 0 | true | Domain | Probable helicase, winged helix domain | Probable helicase, winged helix domain | WH_1 | 2 |
IPR060542 | 60,542 | Probable helicase domain | Helicase_dom | Domain | 5,576 | false | false | This domain is found in uncharacterised bacterial proteins. It shares significant similarity to known helicase domains and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28555"
] | [
"Helicase_dom"
] | [
5576
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR014001"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
5452,
25,
7,
92
] | 4 | [] | [] | 0 | true | Domain | Probable helicase domain | Probable helicase domain | Helicase_dom | 7 |
IPR060543 | 60,543 | YacL/YCF81-like, N-terminal domain | YacL/YCF81-like_N | Domain | 4,028 | false | false | This entry represents the N-terminal domain of a group of uncharacterised proteins mainly found in firmicutes, including Uncharacterized PIN and TRAM-domain containing protein YacL from Bacillus subtilis, a putative RNase. This domain is also found at the N-terminal of the green algae uncharacterised protein YCF81 [ ].... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27675"
] | [
"YCF81_N"
] | [
4028
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162412"
] | [
"10688199"
] | [
"Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3965,
7,
56
] | 3 | [] | [] | 0 | true | Domain | YacL/YCF81-like, N-terminal domain | YacL/YCF81-like, N-terminal domain | YacL/YCF81-like_N | 3 |
IPR060544 | 60,544 | BIG1, C-terminal domain | BIG1_C | Domain | 22 | false | false | This entry represents the C-terminal domain of BIG1 proteins found in Saccharomycetales. BIG1 proteins are endoplasmic reticulum membrane proteins required for normal beta-1,6-glucan synthesis in the cell wall [ ]. Members of this group are single-pass type I membrane proteins with a large N-terminal lumenal domain, a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27678"
] | [
"BIG1_C"
] | [
22
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017135"
] | [
"12112232"
] | [
"Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
22
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | BIG1, C-terminal domain | BIG1, C-terminal domain | BIG1_C | 7 |
IPR060545 | 60,545 | RPM1 interacting protein 13, N-terminal domain | RIN13_N | Domain | 2,474 | false | false | This entry represents the N-terminal domain of RIN13 proteins, which are resistance protein interactors involved in plant defence responses. RIN13 is nuclear localised and function as positive regulators of RPM1-mediated resistance to neurotrophic bacterial pathogens such as Pseudomonas syringae. These proteins interac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27679"
] | [
"RIN13_N"
] | [
2474
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162278",
"PUB00162279"
] | [
"15722472",
"32446355"
] | [
"RIN13 is a positive regulator of the plant disease resistance protein RPM1.",
"The nuclear localized RIN13 induces cell death through interacting with ARF1."
] | [
2005,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2474
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
1,
11,
18
] | 4 | true | Domain | RPM1 interacting protein 13, N-terminal domain | RPM1 interacting protein 13, N-terminal domain | RIN13_N | 5 |
IPR060548 | 60,548 | CEP131, coiled-coil domain | CEP131_CC | Domain | 2,128 | false | false | This entry represents a coiled-coil domain found in Centrosomal protein of 131 kDa (CEP131) mainly from animals. CEP131 proteins are required for cilium formation, intraciliary transport, and transition zone assembly [ , ]. The coiled-coil structure likely mediates protein-protein interactions. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27681"
] | [
"CEP131_CC"
] | [
2128
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [] | 0 | [
"PUB00072972",
"PUB00072973",
"PUB00072974",
"PUB00076882",
"PUB00078201",
"PUB00092417",
"PUB00161868",
"PUB00161869",
"PUB00161870",
"PUB00161871"
] | [
"24415959",
"22797915",
"24550735",
"26297806",
"17954613",
"24121310",
"19254375",
"24185901",
"26616734",
"30804208"
] | [
"Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.",
"The centriolar satellite protein Cep131 is important for genome stability.",
"The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.",
"Centriolar satellites assem... | [
2013,
2012,
2014,
2015,
2007,
2013,
2009,
2013,
2015,
2019
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
2122
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
4,
2,
2
] | 5 | true | Domain | CEP131, coiled-coil domain | CEP131, coiled-coil domain | CEP131_CC | 8 |
IPR060549 | 60,549 | CEP131, C-terminal domain | CEP131_C | Domain | 2,320 | false | false | This entry represents the C-terminal domain found in Centrosomal protein of 131 kDa (CEP131) mainly from animals. CEP131 proteins are required for cilium formation, intraciliary transport, and transition zone assembly [ , ]. Its function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27695"
] | [
"CEP131_C"
] | [
2320
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [] | 0 | [
"PUB00072972",
"PUB00072973",
"PUB00072974",
"PUB00076882",
"PUB00078201",
"PUB00092417",
"PUB00161868",
"PUB00161869",
"PUB00161870",
"PUB00161871"
] | [
"24415959",
"22797915",
"24550735",
"26297806",
"17954613",
"24121310",
"19254375",
"24185901",
"26616734",
"30804208"
] | [
"Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.",
"The centriolar satellite protein Cep131 is important for genome stability.",
"The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.",
"Centriolar satellites assem... | [
2013,
2012,
2014,
2015,
2007,
2013,
2009,
2013,
2015,
2019
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloarculaceae"
] | [
5,
2312,
3
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
6,
2,
2
] | 5 | true | Domain | CEP131, C-terminal domain | CEP131, C-terminal domain | CEP131_C | 4 |
IPR060550 | 60,550 | Interactor of constitutive active ROPs 1-5, C-terminal domain | ICR1-5_C | Domain | 2,575 | false | false | This entry represents the C-terminal coiled-coil domain found in plant ICR1-5 proteins (Interactor of constitutive active ROPs 1-5). ICR proteins are involved in ROP-regulated polar growth and cortical microtubule organisation [ , ]. The coiled-coil structure of this domain likely mediates protein-protein interactions. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27682"
] | [
"ICR5_C"
] | [
2575
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097078",
"PUB00113036"
] | [
"22984069",
"20832900"
] | [
"Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking.",
"RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules."
] | [
2012,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Spermatophyta"
] | [
2575
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
13,
26
] | 3 | true | Domain | Interactor of constitutive active ROPs 1-5, C-terminal domain | Interactor of constitutive active ROPs 1-5, C-terminal domain | ICR1-5_C | 2 |
IPR060551 | 60,551 | ANKRD40-like, ubiquitin-like domain | ANKRD40-like_UBL | Domain | 1,813 | false | false | This entry represents an ubiquitin-like fold domain found in ANKRD40 (ankyrin repeat domain-containing protein 40) and similar animal proteins. ANKRD40 proteins show tissue-enhanced expression in brain and other tissues. The proteins contain multiple disordered regions with compositional bias towards proline and acidic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27687"
] | [
"ANKRD40_UBL"
] | [
1813
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1813
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
6
] | 4 | true | Domain | ANKRD40-like, ubiquitin-like domain | ANKRD40-like, ubiquitin-like domain | ANKRD40-like_UBL | 8 |
IPR060552 | 60,552 | EXO84A-C, helical domain | EXO84A-C_helical | Domain | 2,271 | false | false | This entry represents a helical domain found in plant EXO84 proteins, including Arabidopsis EXO84A, EXO84B, and EXO84C, which are components of the exocyst complex. EXO84 proteins are involved in exocytosis, vesicle docking, and cell plate formation during cytokinesis [ ]. This domain is located in the middle region of... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27696"
] | [
"EXO84_helical"
] | [
2271
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161946"
] | [
"20870962"
] | [
"The Arabidopsis exocyst complex is involved in cytokinesis and cell plate maturation."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2271
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
15,
31
] | 3 | true | Domain | EXO84A-C, helical domain | EXO84A-C, helical domain | EXO84A-C_helical | 2 |
IPR060553 | 60,553 | Endosomal transmembrane epsin interactor 1/2, C-terminal domain | ENTREP1/2_C | Domain | 1,767 | false | false | This entry represents a C-terminal domain found in human endosomal transmembrane epsin interactor 1/2 (ENTREP1/2) and related proteins mainly from vertebrates. ENTREP1 functions as an activator of the E3 ubiquitin protein ligase ITCH in receptor ubiquitination [ ]. This domain is located in the cytoplasmic region towar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27697"
] | [
"ENTREP_C"
] | [
1767
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00101333"
] | [
"34927784"
] | [
"ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
1767
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
3,
8
] | 4 | true | Domain | Endosomal transmembrane epsin interactor 1/2, C-terminal domain | Endosomal transmembrane epsin interactor 1/2, C-terminal domain | ENTREP1/2_C | 2 |
IPR060555 | 60,555 | Shisa-4/5, helical domain | Shisa4/5_helical | Domain | 1,818 | false | false | This entry represents an helical domain found in Shisa-4/5 and related proteins mainly found in vertebrates. Members are single-pass type I transmembrane proteins localised to the endoplasmic reticulum and nuclear membranes [ ]. Shisa-5 proteins can induce apoptosis in a caspase-dependent manner and play a role in p53-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27717"
] | [
"Shisa5_N"
] | [
1818
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275"
] | [
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275"
] | 6 | [] | 0 | [
"PUB00062020",
"PUB00137409"
] | [
"12135983",
"17889823"
] | [
"Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.",
"The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane."
] | [
2002,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1818
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
10,
15
] | 4 | true | Domain | Shisa-4/5, helical domain | Shisa-4/5, helical domain | Shisa4/5_helical | 4 |
IPR060556 | 60,556 | Epg5-like, TPR-like | TPR-like_Epg5 | Domain | 1,769 | false | false | This entry represents a TPR-like region found in EPG5 (Ectopic P granules protein 5 homolog) proteins mainly found in animals. EPG5 is involved in autophagy [ ]. Mutations in the human member are related with Vici syndrome [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27737"
] | [
"TPR-like_Epg5"
] | [
1769
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070607",
"PUB00161491",
"PUB00161495"
] | [
"23222957",
"26917586",
"29130391"
] | [
"Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy.",
"EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy.",
"The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate an... | [
2013,
2016,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1769
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
9,
1,
4
] | 6 | true | Domain | Epg5-like, TPR-like | Epg5-like, TPR-like | TPR-like_Epg5 | 9 |
IPR060558 | 60,558 | Epg5-like, N-terminal domain | Epg5_N | Domain | 2,063 | false | false | This entry represents the N-terminal domain in EPG5 (Ectopic P granules protein 5 homolog) proteins mainly found in animals. EPG5 is involved in autophagy. The domain shares structural similarity with TPR motifs but may have diverged sequence characteristics. The function of this domain remains to be determined [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27745"
] | [
"Epg5_N"
] | [
2063
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161491"
] | [
"26917586"
] | [
"EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2063
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
9,
1,
4
] | 6 | true | Domain | Epg5-like, N-terminal domain | Epg5-like, N-terminal domain | Epg5_N | 6 |
IPR060559 | 60,559 | Cephalotoxin-like, helical domain | CTXL-like_helical | Domain | 1,840 | false | false | This entry represents an helical domain found near the N-terminal of SE-cephalotoxin (CTX) and similar animal proteins. CTX is a secreted protein found in the coral Acropora millepora and is a component of the organic matrix of the aragonitic skeleton [ ]. The protein includes coiled-coil regions. This domain is compos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27742"
] | [
"CTXL_M"
] | [
1840
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088457",
"PUB00090163"
] | [
"23765379",
"19632218"
] | [
"The skeletal proteome of the coral Acropora millepora: the evolution of calcification by co-option and domain shuffling.",
"A gain of function mutation causing skeletal overgrowth in the rapunzel mutant."
] | [
2013,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
1835
] | 2 | [
"Danio rerio"
] | [
11
] | 1 | true | Domain | Cephalotoxin-like, helical domain | Cephalotoxin-like, helical domain | CTXL-like_helical | 3 |
IPR060560 | 60,560 | SAAL1, C-terminal domain | SAAL1_C | Domain | 1,266 | false | false | This entry represents the C-terminal domain of the Synoviocyte proliferation-associated in collagen-induced arthritis protein 1 (SAAL1) and related proteins. SAAL1 is a nuclear protein found in vertebrates that plays a role in promoting cell proliferation in response to pro-inflammatory stimuli [ ]. The full-length pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28174"
] | [
"SAAL1_C"
] | [
1266
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162285"
] | [
"22127701"
] | [
"Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1266
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
10,
2,
4
] | 4 | true | Domain | SAAL1, C-terminal domain | SAAL1, C-terminal domain | SAAL1_C | 8 |
IPR060562 | 60,562 | SERAC1, N-terminal | SERAC1_N | Domain | 1,814 | false | false | This entry represents a domain found towards the N-terminal end of SERAC1 (Serine active site-containing protein 1) and related proteins. This domain forms a small α-helical bundle. SERAC1 is found in eukaryotes and facilitates serine transport from cytosol to mitochondria by stabilising sideroflexin-1 [ , ]. The full-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27756"
] | [
"SERAC1_N"
] | [
1814
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154889",
"PUB00162290"
] | [
"22683713",
"35235340"
] | [
"Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.",
"SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA."
] | [
2012,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1814
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
1,
7,
1,
6
] | 5 | true | Domain | SERAC1, N-terminal | SERAC1, N-terminal | SERAC1_N | 2 |
IPR060563 | 60,563 | Transmembrane protein 88/278 domain | TMEM88/278_dom | Domain | 1,362 | false | false | This entry represents a domain found in the transmembrane protein 88 (TMEM88), TMEM278 and similar sequences found in vertebrates. TMEM88 proteins are multi-pass membrane proteins localised to the cell membrane and contain multiple transmembrane helical domains. TMEM88 is an inhibitor of the Wnt/beta-catenin signalling... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27917"
] | [
"TMEM88"
] | [
1362
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078525",
"PUB00078526"
] | [
"23924634",
"21044957"
] | [
"Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.",
"Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."
] | [
2013,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1362
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
2,
7
] | 4 | true | Domain | Transmembrane protein 88/278 domain | Transmembrane protein 88/278 domain | TMEM88/278_dom | 9 |
IPR060564 | 60,564 | Mirror-image polydactyly gene 1 protein, N-terminal domain | MIPOL1_N | Domain | 1,508 | false | false | This entry represents the N-terminal domain of mirror-image polydactyly gene 1 (MIPOL1) proteins found in animals. The N-terminal region is predicted to be largely disordered and contains polar residue-rich regions followed by this helical domain. The specific function of this domain remains to be determined. MIPOL1 is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27918"
] | [
"MIPOL1_N"
] | [
1508
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060160"
] | [
"11954550"
] | [
"A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Flavobacteriaceae"
] | [
1506,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
14,
8,
11
] | 4 | true | Domain | Mirror-image polydactyly gene 1 protein, N-terminal domain | Mirror-image polydactyly gene 1 protein, N-terminal domain | MIPOL1_N | 3 |
IPR060565 | 60,565 | Mirror-image polydactyly gene 1 protein, C-terminal domain | MIPOL1_C | Domain | 1,194 | false | false | This entry represents the C-terminal domain of mirror-image polydactyly gene 1 (MIPOL1) proteins found in animals. The specific function of this domain remains to be determined. MIPOL1 is a nuclear protein that is expressed during embryonic development, particularly between 10.5 and 13.5 days post-coitum in mice [ ]. T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27921"
] | [
"MIPOL1_C"
] | [
1194
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060160"
] | [
"11954550"
] | [
"A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1194
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
15,
6,
10
] | 4 | true | Domain | Mirror-image polydactyly gene 1 protein, C-terminal domain | Mirror-image polydactyly gene 1 protein, C-terminal domain | MIPOL1_C | 3 |
IPR060566 | 60,566 | HI_1128-like, transmembrane domain | HI_1128_dom | Domain | 203 | false | false | This entry represents a transmembrane domain covering large portion of the HI_1128 proteins found in Haemophilus influenzae. The protein contains a single transmembrane helix and is found predominantly in Gammaproteobacteria, with representatives in Pasteurellales and Moraxellales orders. The function of this protein r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27396"
] | [
"HI_1128"
] | [
203
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
203
] | 1 | [] | [] | 0 | true | Domain | HI_1128-like, transmembrane domain | HI_1128-like, transmembrane domain | HI_1128_dom | 8 |
IPR060567 | 60,567 | TM7SF3-like, second immunoglobulin-like domain | Ig_TM7SF3_2nd | Domain | 1,560 | false | false | This domain is found towards the N-terminal of human Transmembrane 7 superfamily member 3 (TM7SF3) and similar animal proteins. TM7SF3 is involved in the inhibition of cytokine-induced death of pancreatic beta cells and in the promotion of insulin secretion. It acts as a pro-survival homeostatic factor that attenuates ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27919"
] | [
"Ig_TM7SF3_2nd"
] | [
1560
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093040",
"PUB00093041"
] | [
"27740623",
"21853325"
] | [
"TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.",
"An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic b... | [
2017,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1560
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
10,
2,
4
] | 4 | true | Domain | TM7SF3-like, second immunoglobulin-like domain | TM7SF3-like, second immunoglobulin-like domain | Ig_TM7SF3_2nd | 1 |
IPR060568 | 60,568 | Transmembrane protein 183, C-terminal domain | TMEM183_C | Domain | 1,475 | false | false | This entry represents the C-terminal domain of transmembrane protein 183 (TMEM183) proteins found in animals. These proteins are single-pass membrane proteins that have a single transmembrane helix located near the C-terminal region. Many members contain an F-box-like domain ( ) and are associated with SCF ubiquitin li... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27923"
] | [
"TMEM183_C"
] | [
1475
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162335"
] | [
"16644869"
] | [
"Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1475
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
1,
4
] | 5 | true | Domain | Transmembrane protein 183, C-terminal domain | Transmembrane protein 183, C-terminal domain | TMEM183_C | 6 |
IPR060569 | 60,569 | FAM237B, N-terminal domain | FAM237B_N | Domain | 464 | false | false | This entry represents the N-terminal in FAM237B (Family with sequence similarity 237 member B) secreted proteins from vertebrates, which contain an N-terminal signal peptide for secretion. The mature protein undergoes C-terminal processing with removal of a propeptide region. FAM237B requires C-terminal amidation and d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27929"
] | [
"FAM237B_N"
] | [
464
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161954"
] | [
"32713278"
] | [
"A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
464
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1
] | 3 | true | Domain | FAM237B, N-terminal domain | FAM237B, N-terminal domain | FAM237B_N | 1 |
IPR060570 | 60,570 | Dicer-like protein 2, dsRNA binding domain | DSRM_DCL2 | Domain | 623 | false | false | This domain is found at the C-terminal end of Dicer-like protein 2 from Pyricularia oryzae (DCL2) and related proteins. DCL2 is involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It is part of a broad host defence response against viral infection and transposons [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26980"
] | [
"DSRM_DCL2"
] | [
623
] | 1 | [
"EC",
"EC",
"METACYC"
] | [
"3.1.26.-",
"3.6.4.-",
"PWY-7250"
] | [
"EC:3.1.26.-",
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 3 | [] | 0 | [
"PUB00161910"
] | [
"15304480"
] | [
"One of the two Dicer-like proteins in the filamentous fungi Magnaporthe oryzae genome is responsible for hairpin RNA-triggered RNA silencing and related small interfering RNA accumulation."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Pezizomycotina"
] | [
623
] | 1 | [] | [] | 0 | true | Domain | Dicer-like protein 2, dsRNA binding domain | Dicer-like protein 2, dsRNA binding domain | DSRM_DCL2 | 8 |
IPR060572 | 60,572 | CCDC61, coiled-coil domain | CCDC61_coil | Domain | 1,043 | false | false | This entry represents the coiled-coil domain of CCDC61 (coiled-coil domain-containing protein 61) found predominantly in animals. CCDC6 functions in centriole cohesion, microtubule anchoring at centrosome subdistal appendages, and spindle assembly during mitosis. This domain is located downstream of the N-terminal head... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27935"
] | [
"CCDC61_coil"
] | [
1043
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00108977",
"PUB00110097",
"PUB00147244"
] | [
"30354798",
"32375023",
"31789463"
] | [
"Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.",
"CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.",
"hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning."
] | [
2018,
2020,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"marine metagenome"
] | [
1040,
2,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
2,
2
] | 4 | true | Domain | CCDC61, coiled-coil domain | CCDC61, coiled-coil domain | CCDC61_coil | 5 |
IPR060573 | 60,573 | NADH-ubiquinone oxidoreductase 17.8kDa, helical domain | Nuo178_helical | Domain | 1,354 | false | false | This entry represents the helical domain found in the 17.8 kDa subunit of NADH-ubiquinone oxidoreductase subunit (Nuo17.8) and similar fungal proteins. This domain contains a single transmembrane helix that anchors the protein in the mitochondrial inner membrane. Nuo17.8 is involved in electron transfer from NADH to ub... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27975"
] | [
"Nuo178_helical"
] | [
1354
] | 1 | [] | [] | [] | 0 | [
"7zm7",
"7zm8",
"7zmb",
"7zme",
"7zmg",
"7zmh"
] | 6 | [
"PUB00083559"
] | [
"8343129"
] | [
"Cloning, in vitro mitochondrial import and membrane assembly of the 17.8 kDa subunit of complex I from Neurospora crassa."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1354
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | NADH-ubiquinone oxidoreductase 17.8kDa, helical domain | NADH-ubiquinone oxidoreductase 17.8kDa, helical domain | Nuo178_helical | 2 |
IPR060574 | 60,574 | YxeC-like, helical transmembrane domain | YxeC-like | Domain | 397 | false | false | This entry represents a domain found standalone in the YxeC protein from Bacillus subtilis. YxeC is an uncharacterised multi-pass membrane protein predicted to localise to the cell membrane with three transmembrane helices [ ]. The protein is located in a genomic region between the iol and hut operons. In some proteins... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27171"
] | [
"YxeC"
] | [
397
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162429"
] | [
"8867804"
] | [
"Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome between the iol and hut operons."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriaceae",
"human gut metagenome"
] | [
383,
13,
1
] | 3 | [] | [] | 0 | true | Domain | YxeC-like, helical transmembrane domain | YxeC-like, helical transmembrane domain | YxeC-like | 7 |
IPR060575 | 60,575 | SAM-like, helix-hairpin-helix tandem | HHH_3 | Domain | 50,937 | false | false | This entry represents a SAM-like helix-hairpin-helix (HhH) domain found in proteins with diverse functions such as Kinesin-like protein KIF22, Transcription elongation factor (TEFM), ComE operon protein 1 and similar sequences. The HhH motif is known to recognise DNA in a sequence independent manner [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12836"
] | [
"HHH_3"
] | [
50937
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-983189",
"R-HSA-2132295",
"R-HSA-6811434",
"R-HSA-9029569",
"R-HSA-983189",
"R-MMU-2132295",
"R-MMU-6811434",
"R-MMU-983189",
"R-RNO-2132295",
"R-RNO-6811434",
"R-RNO-983189",
"R-XTR-6811434",
"R-XTR-983189"
] | [
"REACTOME:R-DRE-983189",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-6811434",
"REACTOME:R-HSA-9029569",
"REACTOME:R-HSA-983189",
"REACTOME:R-MMU-2132295",
"REACTOME:R-MMU-6811434",
"REACTOME:R-MMU-983189",
"REACTOME:R-RNO-2132295",
"REACTOME:R-RNO-6811434",
"REACTOME:R-RNO-983189",
"REACTOME:R-... | 13 | [
"2duy",
"2edu",
"2oce",
"3bzc",
"3bzk",
"5ol8",
"5ol9",
"8dfk",
"8dss",
"9mna"
] | 10 | [
"PUB00004467",
"PUB00044227"
] | [
"8692686",
"18439896"
] | [
"The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.",
"Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates."
] | [
1996,
2008
] | 2 | [] | [
"IPR004509"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
176,
44367,
5693,
31,
670
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
21,
1,
2,
15,
8,
2,
16,
16
] | 10 | true | Domain | SAM-like, helix-hairpin-helix tandem | SAM-like, helix-hairpin-helix tandem | HHH_3 | 8 |
IPR060576 | 60,576 | RASSF9/10, helical domain | RASSF9/10_helical | Domain | 1,378 | false | false | This entry represents a helical domain found in mouse RASSF9/10 (Ras association domain-containing 9 and 10) and similar proteins found in vertebrates. RASSF9 is thought to play a role in regulating vesicular trafficking in cells, while RASSF10 plays an important role in regulating embryonic neurogenesis [ ]. RASSF pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27976"
] | [
"RASSF_helical"
] | [
1378
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00079351",
"PUB00162528"
] | [
"9837933",
"29490266"
] | [
"P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.",
"Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain."
] | [
1998,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1378
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
7
] | 4 | true | Domain | RASSF9/10, helical domain | RASSF9/10, helical domain | RASSF9/10_helical | 2 |
IPR060577 | 60,577 | CEP70, C-terminal domain | CEP70_C | Domain | 1,243 | false | false | This entry represents the C-terminal domain of CEP70 (centrosomal protein of 70 kDa) and similar animal proteins. CEP70 is a centrosomal protein plays a role in organising both preexisting and nascent microtubules in interphase cells and is required for mitotic spindle organisation. It idirectly interacts with gamma-tu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27977"
] | [
"CEP70_C_terminal"
] | [
1243
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [] | 0 | [
"PUB00060222",
"PUB00087481"
] | [
"14654843",
"21795687"
] | [
"Proteomic characterization of the human centrosome by protein correlation profiling.",
"CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly."
] | [
2003,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1243
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
4,
1,
8
] | 4 | true | Domain | CEP70, C-terminal domain | CEP70, C-terminal domain | CEP70_C | 5 |
IPR060578 | 60,578 | Zinc finger protein 318-like, helical domain | ZNF318-like_helical | Domain | 1,424 | false | false | This entry represents a helical domain found in zinc finger protein 318 (ZNF318) and similar animal proteins. ZNF318 is a transcriptional regulator that acts as either a coactivator or corepressor for androgen receptor-mediated transactivation depending on the isoform. The protein is expressed in endocrine tissues and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27978"
] | [
"ZNF318_helical"
] | [
1424
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061748"
] | [
"9853615"
] | [
"Selection system for genes encoding nuclear-targeted proteins."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Mariniphaga sediminis",
"Opisthokonta"
] | [
1,
1423
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
1,
2,
4
] | 5 | true | Domain | Zinc finger protein 318-like, helical domain | Zinc finger protein 318-like, helical domain | ZNF318-like_helical | 9 |
IPR060579 | 60,579 | C2H2 finger domain transcription factor CON7, helical domain | CON7_helical | Domain | 1,420 | false | false | This entry represents a helical domain found in C2H2 finger domain transcription factor CON7 from the rice blast fungus Pyricularia oryzae and other transcription factor from fungi. CON7 plays a central role in appressorium formation and pathogenicity [ ]. The protein is required for expression of genes involved in mem... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27979"
] | [
"CON7_helical"
] | [
1420
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089447",
"PUB00161885"
] | [
"17378924",
"9487695"
] | [
"The transcription factor Con7p is a central regulator of infection-related morphogenesis in the rice blast fungus Magnaporthe grisea.",
"Interactions between spore morphogenetic mutations affect cell types, sporulation, and pathogenesis in Magnaporthe grisea."
] | [
2007,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1420
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | C2H2 finger domain transcription factor CON7, helical domain | C2H2 finger domain transcription factor CON7, helical domain | CON7_helical | 4 |
IPR060581 | 60,581 | Embryogenesis-like protein, helical domain | EML_helical | Domain | 1,472 | false | false | This entry represents a helical bundle domain found in the embryogenesis-like protein (EML) from Arabidopsis thaliana and similar eukaryotic proteins. EML is a nuclear transcriptional activator that recruits HAG1/GCN5 and triggers histone H3 acetylation of target gene promoters [ ]. The protein is expressed in flowers,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27980"
] | [
"EML_helical"
] | [
1472
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161935"
] | [
"17151888"
] | [
"Isolation and characterization of a GCN5-interacting protein from Arabidopsis thaliana."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1472
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
2,
4
] | 3 | true | Domain | Embryogenesis-like protein, helical domain | Embryogenesis-like protein, helical domain | EML_helical | 3 |
IPR060582 | 60,582 | RNA demethylase ALKBH10B, N-terminal domain | ALKBH10B_N | Domain | 1,740 | false | false | This entry represents the N-terminal domain of RNA demethylase ALKBH10B from Arabidopsis thaliana and similar plant sequences. ALKBH10B is an alpha-ketoglutarate-dependent dioxygenase that specifically demethylates N6-methyladenosine in mRNA, affecting floral transition by stabilising mRNAs of flowering time regulators... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27981"
] | [
"ALKBH10B_N"
] | [
1740
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097318"
] | [
"29180595"
] | [
"ALKBH10B Is an RNA N6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1740
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
8,
12
] | 3 | true | Domain | RNA demethylase ALKBH10B, N-terminal domain | RNA demethylase ALKBH10B, N-terminal domain | ALKBH10B_N | 1 |
IPR060583 | 60,583 | Apical junction component 1, C-terminal domain | AJM1_C | Domain | 1,423 | false | false | This entry represents the C-terminal domain of apical junction component 1 (AJM1), a protein involved in adherens junction integrity. AJM1 localises to the apical cell membrane, adherens junctions and cilia, where it may control cell-cell junction organisation. The protein contains extensive disordered regions througho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27982"
] | [
"AJM1_C"
] | [
1423
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088455"
] | [
"11715019"
] | [
"Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1423
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
1,
1,
1
] | 5 | true | Domain | Apical junction component 1, C-terminal domain | Apical junction component 1, C-terminal domain | AJM1_C | 1 |
IPR060584 | 60,584 | CUEDC2, N-terminal domain | CUEDC2_N | Domain | 1,324 | false | false | This entry represents the N-terminal domain of CUEDC2 animal proteins. CUEDC2 control progesterone receptor and oestrogen receptor alpha protein levels through their targeting for ubiquitination and subsequent proteasomal degradation [ , ]. The proteins are located in both the cytoplasm and nucleus. The specific functi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27983"
] | [
"CUEDC2_N"
] | [
1324
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00036137",
"PUB00090135"
] | [
"17347654",
"21572428"
] | [
"CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.",
"Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer."
] | [
2007,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1324
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
8,
4
] | 5 | true | Domain | CUEDC2, N-terminal domain | CUEDC2, N-terminal domain | CUEDC2_N | 7 |
IPR060586 | 60,586 | CRLF3, N-terminal coiled-coil domain | CRLF3_N | Domain | 1,252 | false | false | This entry represents the N-terminal coiled-coil domain of cytokine receptor-like factor 3 (CRLF3) animal proteins. CRLF3 proteins may play a role in the negative regulation of cell cycle progression [ ]. The proteins are localised to the cytoplasm and contain a fibronectin type-III domain in addition to this N-termina... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27984"
] | [
"CRLF3_N"
] | [
1252
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161887"
] | [
"19427400"
] | [
"Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1252
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
6
] | 4 | true | Domain | CRLF3, N-terminal coiled-coil domain | CRLF3, N-terminal coiled-coil domain | CRLF3_N | 4 |
IPR060587 | 60,587 | ROS1, fibronectin type III domain | Fn3_ROS1 | Domain | 1,365 | false | false | This fibronectin type III domain (Fn3) is found in human Proto-oncogene tyrosine-protein kinase ROS (ROS1) and similar animal proteins, including its orthologue Protein roller-3 from Caenorhabditis elegans. ROS1 plays a role in epithelial cell differentiation and regionalisation of the proximal epididymal epithelium [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28033"
] | [
"Fn3_ROS1"
] | [
1365
] | 1 | [
"EC",
"REACTOME"
] | [
"2.7.10.1",
"R-CEL-8863795"
] | [
"EC:2.7.10.1",
"REACTOME:R-CEL-8863795"
] | 2 | [] | 0 | [
"PUB00160112",
"PUB00161449"
] | [
"8138151",
"1752418"
] | [
"The generation and genetic analysis of suppressors of lethal mutations in the Caenorhabditis elegans rol-3(V) gene.",
"Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans."
] | [
1994,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
8,
1357
] | 2 | [
"Caenorhabditis elegans",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
7
] | 4 | true | Domain | ROS1, fibronectin type III domain | ROS1, fibronectin type III domain | Fn3_ROS1 | 4 |
IPR060588 | 60,588 | Phosphatidylserine decarboxylase proenzyme, N-terminal domain | PSD_N | Domain | 6,035 | false | false | This entry represents a domain that covers the N-terminal in phosphatidylserine decarboxylase proenzyme (PSD) from alpha, beta and gammaproteobacteria. This domain also covers the entire length of PSD in Azotobacter vinelandii ( ]) which is smaller compared to other PSD proteins. This domain contains an all helical fol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27523"
] | [
"PSD"
] | [
6035
] | 1 | [
"EC",
"METACYC"
] | [
"4.1.1.65",
"PWY-5669"
] | [
"EC:4.1.1.65",
"METACYC:PWY-5669"
] | 2 | [
"6l06",
"6l07",
"7cnw",
"7cnx",
"7cny",
"7cnz"
] | 6 | [
"PUB00008264",
"PUB00008265",
"PUB00162269"
] | [
"8407984",
"7890740",
"4598120"
] | [
"Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele.",
"Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele.",
"Purification... | [
1993,
1995,
1974
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5974,
5,
56
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Phosphatidylserine decarboxylase proenzyme, N-terminal domain | Phosphatidylserine decarboxylase proenzyme, N-terminal domain | PSD_N | 4 |
IPR060590 | 60,590 | POLR1D, N-terminal domain | POLR1D_N | Domain | 1,310 | false | false | This entry represents the N-terminal domain of the short isoform of POLR1D, also known as isoform 2, and similar proteins from animals and fungi. The truncated protein of only 122 amino acids contains extensive disordered regions and cannot function as a DNA-dependent RNA polymerase due to the absence of the catalytic ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28113"
] | [
"POLR1D"
] | [
1310
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1834949",
"R-HSA-427413",
"R-HSA-5250924",
"R-HSA-73762",
"R-HSA-73772",
"R-HSA-73780",
"R-HSA-73863",
"R-HSA-73980",
"R-HSA-749476",
"R-HSA-76061",
"R-HSA-76066",
"R-HSA-76071"
] | [
"REACTOME:R-HSA-1834949",
"REACTOME:R-HSA-427413",
"REACTOME:R-HSA-5250924",
"REACTOME:R-HSA-73762",
"REACTOME:R-HSA-73772",
"REACTOME:R-HSA-73780",
"REACTOME:R-HSA-73863",
"REACTOME:R-HSA-73980",
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76061",
"REACTOME:R-HSA-76066",
"REACTOME:R-HSA-76071"
] | 12 | [] | 0 | [
"PUB00162260"
] | [
"30582221"
] | [
"POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1310
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
7,
5,
3
] | 5 | true | Domain | POLR1D, N-terminal domain | POLR1D, N-terminal domain | POLR1D_N | 9 |
IPR060591 | 60,591 | F-box protein SKIP28-like, C-terminal domain | SKIP28-like_C | Domain | 1,638 | false | false | This entry represents the C-terminal domain of SKIP28 and similar F-box proteins found in plants. F-box proteins are components of SCF (ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins [ ]. These proteins contain a F-box domain t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28114"
] | [
"At3g27290_F_box_C"
] | [
1638
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00033544",
"PUB00102382"
] | [
"12795696",
"15634699"
] | [
"Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis.",
"Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis."
] | [
2003,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1638
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
6,
12
] | 3 | true | Domain | F-box protein SKIP28-like, C-terminal domain | F-box protein SKIP28-like, C-terminal domain | SKIP28-like_C | 5 |
IPR060592 | 60,592 | Long chronological lifespan protein 2, C-terminal domain | LCL2_C | Domain | 1,268 | false | false | This entry represents the C-terminal domain of long chronological lifespan protein 2 (LCL2) and similar sequences found in fungi. LCL2 is a probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. The protein belongs to the LCL2 family and is synthesised as a precursor with an N-terminal s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28115"
] | [
"LCL2_C"
] | [
1268
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162121"
] | [
"20547848"
] | [
"Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1268
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Long chronological lifespan protein 2, C-terminal domain | Long chronological lifespan protein 2, C-terminal domain | LCL2_C | 2 |
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