interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR060593 | 60,593 | Plastid division protein, N-terminal domain | PDV_N | Domain | 1,540 | false | false | This entry represents the N-terminal domain of plastid division proteins PDV1 and PDV2 and similar sequences found in plants. These proteins are components of the plastid division machinery that accomplishes binary fission by simultaneous constriction of the FtsZ ring and the ARC5/DRP5B ring [ , ]. PDV proteins mediate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28116"
] | [
"PDV_N"
] | [
1540
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088583",
"PUB00160084",
"PUB00162222"
] | [
"16998069",
"28248291",
"32005784"
] | [
"PDV1 and PDV2 mediate recruitment of the dynamin-related protein ARC5 to the plastid division site.",
"Structural insights into the coordination of plastid division by the ARC6-PDV2 complex.",
"PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring."
] | [
2006,
2017,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
1540
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
11,
17
] | 3 | true | Domain | Plastid division protein, N-terminal domain | Plastid division protein, N-terminal domain | PDV_N | 5 |
IPR060594 | 60,594 | Zinc finger TRAF-type-containing protein 1, C-terminal domain | CYHR1_C | Domain | 1,379 | false | false | This entry represents the C-terminal TRAF-type zinc finger domain found in cysteine and histidine-rich protein 1 (CYHR1) and related animal proteins. CYHR1 belongs to the ZFTRAF1 family and contains both RING-type and TRAF-type zinc finger domains. The TRAF domain superfamily has a circularly permuted immunoglobulin-fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28124"
] | [
"CYHR1_TRAF_C"
] | [
1379
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161897"
] | [
"19918944"
] | [
"TRAF-mediated TNFR-family signaling."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1379
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
4
] | 5 | true | Domain | Zinc finger TRAF-type-containing protein 1, C-terminal domain | Zinc finger TRAF-type-containing protein 1, C-terminal domain | CYHR1_C | 6 |
IPR060596 | 60,596 | At5g19025-like, N-terminal domain | At5g19025_N | Domain | 1,521 | false | false | This entry represents the N-terminal helical region of the uncharacterised protein At5g19025 from Arabidopsis thaliana and similar plant sequences. At5g19025 is a 259 amino acid multi-pass membrane protein with three predicted transmembrane helical regions. It is localised to cellular membranes [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28125"
] | [
"At5g19025_N"
] | [
1521
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161808"
] | [
"11130714"
] | [
"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1521
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
10,
11
] | 3 | true | Domain | At5g19025-like, N-terminal domain | At5g19025-like, N-terminal domain | At5g19025_N | 1 |
IPR060597 | 60,597 | Nephrocystin-4, second C2-like domain | NPHP4_C2_2nd | Domain | 1,313 | false | false | This entry represents the second C2-like domain found near the N-terminal of nephrocystin-4 (NPHP4) and similar animal sequences. NPHP4 is a ciliary protein involved in the organisation of apical junctions and required for building functional cilia [ , , ]. It has multiple established functions including regulation of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28126"
] | [
"NPHP4_C2_2nd"
] | [
1313
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2028269",
"R-HSA-5620912",
"R-MMU-2028269",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-5620912"
] | 4 | [] | 0 | [
"PUB00070860",
"PUB00074744",
"PUB00074752",
"PUB00089014",
"PUB00129249",
"PUB00148156"
] | [
"21498478",
"16339905",
"17558407",
"26644512",
"19755384",
"21555462"
] | [
"Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros.",
"Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations.",
"Mutations in the gene encoding the basal body protein RPGRIP1L, a nephroc... | [
2011,
2005,
2007,
2015,
2009,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1313
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
1,
3,
2
] | 5 | true | Domain | Nephrocystin-4, second C2-like domain | Nephrocystin-4, second C2-like domain | NPHP4_C2_2nd | 2 |
IPR060598 | 60,598 | Fibronectin type III domain-containing protein 9, helical domain | FNDC9_C | Domain | 1,020 | false | false | This entry represents the helical domain found in fibronectin type III domain-containing protein 9 (FNDC9). The specific function of this domain remains to be determined. This entry includes Fibronectin type III domain-containing protein 9 (FNDC9) and similar proteins from vertebrates. FNDC9 is a single-pass membrane p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28127"
] | [
"FNDC9_C"
] | [
1020
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161967"
] | [
"14702039"
] | [
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1020
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
2
] | 4 | true | Domain | Fibronectin type III domain-containing protein 9, helical domain | Fibronectin type III domain-containing protein 9, helical domain | FNDC9_C | 1 |
IPR060600 | 60,600 | Fibronectin type III domain-containing protein 9 | FNDC9 | Family | 1,046 | false | false | This entry includes Fibronectin type III domain-containing protein 9 (FNDC9) and similar proteins from vertebrates. FNDC9 is a single-pass membrane protein containing an N-terminal fibronectin type-III domain followed by this C-terminal helical region and a large disordered region. The protein is expressed in the brain... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37361"
] | [
""
] | [
1046
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161967"
] | [
"14702039"
] | [
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1046
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
2
] | 4 | true | Family | Fibronectin type III domain-containing protein 9 | Fibronectin type III domain-containing protein 9 | FNDC9 | 7 |
IPR060601 | 60,601 | Transmembrane protein 98, N-terminal helical domain | TMEM98_N | Domain | 1,158 | false | false | This entry represents the N-terminal helical domain of transmembrane protein 98 (TMEM98) animal proteins. TMEM98 is a single-pass type II membrane protein localised to the endoplasmic reticulum and cell membrane [ ]. TMEM98 functions as a negative regulator of oligodendrocyte differentiation and myelination, and the se... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28128"
] | [
"TMEM98_N"
] | [
1158
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100587",
"PUB00162336"
] | [
"25946230",
"30249802"
] | [
"The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells.",
"Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein."
] | [
2015,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1158
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
7,
1,
2
] | 5 | true | Domain | Transmembrane protein 98, N-terminal helical domain | Transmembrane protein 98, N-terminal helical domain | TMEM98_N | 6 |
IPR060603 | 60,603 | Early responsive to dehydration 15 domain | ERD15_dom | Domain | 1,565 | false | false | This entry represents a domain found in the ERD15 (Early Responsive to Dehydration 15) proteins from plants. These are small transcriptional regulators of approximately 125 amino acids that function as DNA-binding proteins. ERD15 binds to the NRP-B promoter to activate the NRP-B-mediated cell death response and serves ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28129"
] | [
"ERD15"
] | [
1565
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090924",
"PUB00161941"
] | [
"17056758",
"21482825"
] | [
"EARLY RESPONSIVE TO DEHYDRATION 15, a negative regulator of abscisic acid responses in Arabidopsis.",
"A novel transcription factor, ERD15 (Early Responsive to Dehydration 15), connects endoplasmic reticulum stress with an osmotic stress-induced cell death signal."
] | [
2006,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1565
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
11,
21
] | 3 | true | Domain | Early responsive to dehydration 15 domain | Early responsive to dehydration 15 domain | ERD15_dom | 5 |
IPR060604 | 60,604 | Rho-type GTPase-activating protein 6, C-terminal | ARHGAP6_C | Domain | 1,131 | false | false | This entry represents the C-terminal region of human Rho GTPase-activating protein 6 (ARHGAP6) and similar proteins from vertebrates, which is mostly disordered. ARHGAP6 functions as a GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. It could regulate the interactions of sign... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28133"
] | [
"XAC1"
] | [
1131
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8980692",
"R-HSA-9013423",
"R-MMU-8980692",
"R-MMU-9013423"
] | [
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013423",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013423"
] | 4 | [] | 0 | [
"PUB00073972",
"PUB00162399"
] | [
"10699171",
"32532821"
] | [
"Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.",
"The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-containing complexes in <i>Trypanosoma brucei</i>."
] | [
2000,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1131
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
4
] | 4 | true | Domain | Rho-type GTPase-activating protein 6, C-terminal | Rho-type GTPase-activating protein 6, C-terminal | ARHGAP6_C | 3 |
IPR060606 | 60,606 | Glycoprotein integral membrane protein 1, C-terminal domain | GINM1_C | Domain | 887 | false | false | This entry represents the C-terminal cytoplasmic domain of the uncharacterised glycoprotein integral membrane protein 1 (GINM1) and similar sequences from vertebrates. GINM1 protein interacts with FATE1. This domain is located on the cytoplasmic side of the membrane and includes the single transmembrane helix. It shows... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28137"
] | [
"GINM1_C"
] | [
887
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00138180"
] | [
"12975309"
] | [
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
887
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
3
] | 4 | true | Domain | Glycoprotein integral membrane protein 1, C-terminal domain | Glycoprotein integral membrane protein 1, C-terminal domain | GINM1_C | 6 |
IPR060612 | 60,612 | XRI1, C-terminal domain | XRI1_C | Domain | 2,217 | false | false | This entry represents the C-terminal domain of protein XRI1 from Arabidopsis thaliana and similar plant proteins. XRI1 is required for mitotic division of the generative cell nucleus and the development of mature tricellular pollen grains, and for male and female meiosis. The protein interacts via its C-terminal domain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27749"
] | [
"XRI1_C"
] | [
2217
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090326",
"PUB00162404",
"PUB00162405"
] | [
"19187040",
"28153919",
"17227549"
] | [
"A novel ATM-dependent X-ray-inducible gene is essential for both plant meiosis and gametogenesis.",
"Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.",
"ATR and ATM play both distinct and additive roles in response to ionizing radiation."
] | [
2009,
2017,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
2217
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
16,
13,
48
] | 3 | true | Domain | XRI1, C-terminal domain | XRI1, C-terminal domain | XRI1_C | 7 |
IPR060613 | 60,613 | Probable acyl-activating enzyme 17/18-like, SAM domain | SAM_AAE17_18-like | Domain | 1,431 | false | false | This SAM domain is found at the N-terminal end of the probable acyl-activating enzymes 17 and 18 from Arabidopsis thaliana (AAE17/18) and similar proteins mainly found in plants, including Hexanoyl-CoA synthase from Cannabis sativa (AAE1). This entry represents the probable acyl-activating enzymes 17 and 18 from Arabid... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27750"
] | [
"SAM_AAE17_18"
] | [
1431
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.2.1.-",
"PWY-301",
"PWY-5045",
"PWY-5136",
"PWY-5660",
"PWY-5752",
"PWY-5922",
"PWY-5923",
"PWY-5924",
"PWY-5927",
"PWY-5958",
"PWY-6457",
"PWY-6593",
"PWY-6670",
"PWY-6722",
"PWY-6799",
"PWY-6926",
"PWY-6948",
"PWY-7007",
"PWY-7288",
"PWY-735",
"PWY-7462",
"PWY-7536",... | [
"EC:6.2.1.-",
"METACYC:PWY-301",
"METACYC:PWY-5045",
"METACYC:PWY-5136",
"METACYC:PWY-5660",
"METACYC:PWY-5752",
"METACYC:PWY-5922",
"METACYC:PWY-5923",
"METACYC:PWY-5924",
"METACYC:PWY-5927",
"METACYC:PWY-5958",
"METACYC:PWY-6457",
"METACYC:PWY-6593",
"METACYC:PWY-6670",
"METACYC:PWY-67... | 53 | [] | 0 | [
"PUB00162286",
"PUB00162529"
] | [
"19043666",
"22353623"
] | [
"Identification of two Arabidopsis genes encoding a peroxisomal oxidoreductase-like protein and an acyl-CoA synthetase-like protein that are required for responses to pro-auxins.",
"The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes."
] | [
2009,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
37,
1392,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
4,
10
] | 3 | true | Domain | Probable acyl-activating enzyme 17/18-like, SAM domain | Probable acyl-activating enzyme 17/18-like, SAM domain | SAM_AAE17_18-like | 3 |
IPR060614 | 60,614 | Probable acyl-activating enzyme 17/18-like | AAE17_18-like | Family | 2,141 | false | false | This entry represents the probable acyl-activating enzymes 17 and 18 from Arabidopsis thaliana (AAE17/18) and similar proteins mainly found in plants, including Hexanoyl-CoA synthase from Cannabis sativa (AAE1). AAE18 may be involved in the peroxisomal activation of 2,4-dichlorophenoxybutyric acid (2,4-DB), a precursor... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44378"
] | [
""
] | [
2141
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.2.1.-",
"PWY-301",
"PWY-5045",
"PWY-5136",
"PWY-5660",
"PWY-5752",
"PWY-5922",
"PWY-5923",
"PWY-5924",
"PWY-5927",
"PWY-5958",
"PWY-6457",
"PWY-6593",
"PWY-6670",
"PWY-6722",
"PWY-6799",
"PWY-6926",
"PWY-6948",
"PWY-7007",
"PWY-7288",
"PWY-735",
"PWY-7462",
"PWY-7536",... | [
"EC:6.2.1.-",
"METACYC:PWY-301",
"METACYC:PWY-5045",
"METACYC:PWY-5136",
"METACYC:PWY-5660",
"METACYC:PWY-5752",
"METACYC:PWY-5922",
"METACYC:PWY-5923",
"METACYC:PWY-5924",
"METACYC:PWY-5927",
"METACYC:PWY-5958",
"METACYC:PWY-6457",
"METACYC:PWY-6593",
"METACYC:PWY-6670",
"METACYC:PWY-67... | 53 | [] | 0 | [
"PUB00162286",
"PUB00162529"
] | [
"19043666",
"22353623"
] | [
"Identification of two Arabidopsis genes encoding a peroxisomal oxidoreductase-like protein and an acyl-CoA synthetase-like protein that are required for responses to pro-auxins.",
"The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes."
] | [
2009,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
81,
2053,
7
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
10,
21
] | 3 | true | Family | Probable acyl-activating enzyme 17/18-like | Probable acyl-activating enzyme 17/18-like | AAE17_18-like | 6 |
IPR060615 | 60,615 | Transcription factor ATEG_07667-like, C-terminal domain | ATEG07667-like_C | Domain | 1,841 | false | false | This entry represents a C-terminal helical domain found in transcription factor ATEG_07667 from Aspergillus terreus and similar fungal proteins. ATEG_07667 regulates both the azasperpyranone A biosynthesis clusters A and B. The protein up-regulates expression of cluster-specific transcription factors ATEG_03638 and ATE... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27751"
] | [
"ATEG07667_C"
] | [
1841
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161812"
] | [
"31908094"
] | [
"Collaborative Biosynthesis of a Class of Bioactive Azaphilones by Two Separate Gene Clusters Containing Four PKS/NRPSs with Transcriptional Crosstalk in Fungi."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1841
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Transcription factor ATEG_07667-like, C-terminal domain | Transcription factor ATEG_07667-like, C-terminal domain | ATEG07667-like_C | 7 |
IPR060616 | 60,616 | Cramped, PI3K-like domain | Cramped_PI3K-like | Domain | 1,779 | false | false | This entry represents a domain with a phosphatidylinositol 3-kinase (PI3K) catalytic subunit-like fold found in cramped and cramped-like animal proteins. Members of this group are nuclear proteins involved in chromatin binding and DNA binding. Human CRAMP1 is a 1269 amino acid protein with a SANT domain at positions 16... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27753"
] | [
"Cramped_PI3K_like"
] | [
1779
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161886"
] | [
"34592200"
] | [
"Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1779
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
3,
1,
2
] | 5 | true | Domain | Cramped, PI3K-like domain | Cramped, PI3K-like domain | Cramped_PI3K-like | 5 |
IPR060617 | 60,617 | SAGA-associated factor 11-like, C-terminal domain | Sgf11-like_C | Domain | 3,744 | false | false | This entry represents the C-terminal domain of SAGA-associated factor 11 eukaryotic proteins. Sgf11 is a subunit of the transcription coactivator SAGA complex in Saccharomyces cerevisiae [ , ]. The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08209"
] | [
"Sgf11"
] | [
3744
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"2lo2",
"3m99",
"3mhh",
"3mhs",
"4fjc",
"4fk5",
"4w4u",
"4wa6",
"4zux",
"6aqr",
"6t9l",
"6tbm"
] | 12 | [
"PUB00017172",
"PUB00087619",
"PUB00157159"
] | [
"15657441",
"25216679",
"28918903"
] | [
"H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.",
"Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.",
"SAGA Is a General Cofactor for RNA Polymerase II Transcription."
] | [
2005,
2014,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
3743,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
6,
1,
4,
2,
3,
4,
1,
1,
4
] | 10 | true | Domain | SAGA-associated factor 11-like, C-terminal domain | SAGA-associated factor 11-like, C-terminal domain | Sgf11-like_C | 9 |
IPR060618 | 60,618 | Reprimo-like, transmembrane helix domain | Reprimo-like_TM | Domain | 1,523 | false | false | This entry represents the transmembrane helix domain (TM) found in reprimo family proteins from vertebrates. These small single-pass membrane proteins are involved in the regulation of p53-dependent G2 arrest of the cell cycle. This domain is located in the central region of the protein and enables membrane localisatio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27763"
] | [
"Reprimo-like"
] | [
1523
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162275"
] | [
"28562620"
] | [
"Reprimo tissue-specific expression pattern is conserved between zebrafish and human."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1523
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
5,
6
] | 4 | true | Domain | Reprimo-like, transmembrane helix domain | Reprimo-like, transmembrane helix domain | Reprimo-like_TM | 8 |
IPR060619 | 60,619 | Protodermal factor 1, C-terminal domain | PDF1_C | Domain | 2,110 | false | false | This entry represents the C-terminal domain of protodermal factor 1 (PDF1) and similar sequences found in plants. PDF1 is involved in the regulation of meristem growth. The protein is expressed specifically in the shoot apical meristem layer L1 in vegetative, inflorescence and floral meristems, as well as in protoderm ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27764"
] | [
"PDF1_C"
] | [
2110
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090315"
] | [
"10483121"
] | [
"Cloning and characterization of an L1 layer-specific gene in Arabidopsis thaliana."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Embryophyta"
] | [
16,
2094
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
16,
40
] | 3 | true | Domain | Protodermal factor 1, C-terminal domain | Protodermal factor 1, C-terminal domain | PDF1_C | 8 |
IPR060620 | 60,620 | Mediator of RNA polymerase II transcription subunit 33, C-terminal domain | MED33_C | Domain | 2,015 | false | false | This entry represents the C-terminal cullin-like repeats domain of Mediator of RNA polymerase II transcription subunit 33 (MED33) from plants, including MED33A and MED33B. The specific function of this domain remains to be determined. MED33A and MED33B are components of the Mediator complex, a coactivator involved in t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27769"
] | [
"MED33_C"
] | [
2015
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053502",
"PUB00089895"
] | [
"17560376",
"22167189"
] | [
"Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit.",
"REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis."
] | [
2007,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Acetobacter sacchari",
"Streptophyta"
] | [
1,
2014
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
10,
49
] | 3 | true | Domain | Mediator of RNA polymerase II transcription subunit 33, C-terminal domain | Mediator of RNA polymerase II transcription subunit 33, C-terminal domain | MED33_C | 1 |
IPR060621 | 60,621 | Mediator of RNA polymerase II transcription subunit 33, middle TPR-like domain | MED33_TPR-like_mid | Domain | 2,127 | false | false | This entry represents a TPR-like domain of Mediator of RNA polymerase II transcription subunit 33 (MED33) from plants, including MED33A and MED33B. MED33A and MED33B are components of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes [ ]. The Med... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27774"
] | [
"MED33_TPR-like_mid"
] | [
2127
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089895",
"PUB00089896"
] | [
"22167189",
"18430946"
] | [
"REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis.",
"Semidominant mutations in reduced epidermal fluorescence 4 reduce phenylpropanoid content in Arabidopsis."
] | [
2012,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
2127
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
11,
49
] | 3 | true | Domain | Mediator of RNA polymerase II transcription subunit 33, middle TPR-like domain | Mediator of RNA polymerase II transcription subunit 33, middle TPR-like domain | MED33_TPR-like_mid | 2 |
IPR060622 | 60,622 | Mediator of RNA polymerase II transcription subunit 33, second TPR-like domain | MED33_TPR-like_2nd | Domain | 1,878 | false | false | This entry represents the second TPR-like domain found in of Mediator of RNA polymerase II transcription subunit 33 (MED33) from plants, including MED33A and MED33B. MED33A and MED33B are components of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27814"
] | [
"MED33_TPR-like_2nd"
] | [
1878
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053502",
"PUB00089895"
] | [
"17560376",
"22167189"
] | [
"Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit.",
"REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis."
] | [
2007,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1878
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
6,
37
] | 3 | true | Domain | Mediator of RNA polymerase II transcription subunit 33, second TPR-like domain | Mediator of RNA polymerase II transcription subunit 33, second TPR-like domain | MED33_TPR-like_2nd | 7 |
IPR060623 | 60,623 | Uncharacterised 80 kDa protein, N-terminal domain | Y80K_N | Domain | 1,185 | false | false | This entry represents the N-terminal domain of an uncharacterised protein family found in ciliates. The domain is found N-terminal to a transmembrane region in proteins of approximately 680 amino acids. Proteins in this group are predicted to be single-pass membrane proteins with extensive N-linked glycosylation. The f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27811"
] | [
"Y80K_N"
] | [
1185
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162409"
] | [
"9199294"
] | [
"Sequence-specific epigenetic effects of the maternal somatic genome on developmental rearrangements of the zygotic genome in Paramecium primaurelia."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1185
] | 1 | [] | [] | 0 | true | Domain | Uncharacterised 80 kDa protein, N-terminal domain | Uncharacterised 80 kDa protein, N-terminal domain | Y80K_N | 5 |
IPR060624 | 60,624 | MSB2-like, C-terminal domain | MSB2-like_C | Domain | 1,746 | false | false | This entry represents the C-terminal α-β plait domain found in MSB2 signalling mucins in fungi. Proteins in this group are plasma membrane sensors involved in osmosensing and MAPK activation for filamentous growth and appressorium formation [ , , , ]. The specific function of this domain is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27810"
] | [
"MSB2_C"
] | [
1746
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097854",
"PUB00162168",
"PUB00162169",
"PUB00162170"
] | [
"21283781",
"8550469",
"19439450",
"1514328"
] | [
"Multiple plant surface signals are sensed by different mechanisms in the rice blast fungus for appressorium formation.",
"HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern in the yeast Saccharomyces cerevisiae.",
"The signaling mucins Msb2 and Hkr1 diff... | [
2011,
1996,
2009,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces turgidiscabies (strain Car8)"
] | [
1745,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2
] | 2 | true | Domain | MSB2-like, C-terminal domain | MSB2-like, C-terminal domain | MSB2-like_C | 5 |
IPR060625 | 60,625 | Ino eighty subunit 1, N-terminal domain | IES1_N | Domain | 1,660 | false | false | This entry represents the N-terminal domain of IES1 (Ino eighty subunit 1) proteins found in fungi. IES1 proteins are components of the chromatin-remodelling INO80 complex, which includes subunits ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80 [ ]. Proteins in this entry are nu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27809"
] | [
"IES1_N"
] | [
1660
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00052413"
] | [
"12887900"
] | [
"Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
1660
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Ino eighty subunit 1, N-terminal domain | Ino eighty subunit 1, N-terminal domain | IES1_N | 9 |
IPR060627 | 60,627 | Ino eighty subunit 1, C-terminal domain | Ies1_C | Domain | 62 | false | false | This entry represents the C-terminal domain of Ino eighty subunit 1 (Ies1) and similar sequences from Saccharomycetales. Ies1 is a component of the chromatin-remodelling INO80 complex, which is involved in transcription regulation. The INO80 complex in yeast comprises at least ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27816"
] | [
"Ies1_C"
] | [
62
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070373",
"PUB00162056"
] | [
"24297934",
"26340092"
] | [
"Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex.",
"Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability."
] | [
2013,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
62
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Ino eighty subunit 1, C-terminal domain | Ino eighty subunit 1, C-terminal domain | Ies1_C | 6 |
IPR060628 | 60,628 | Ino eighty subunit 1, helical domain | Ies1_helical | Domain | 59 | false | false | This entry represents a helical domain of Ino eighty subunit 1 (Ies1) and similar sequences from Saccharomycetales. Ies1 is a component of the chromatin-remodelling INO80 complex, which is involved in transcription regulation [ ]. The INO80 complex in yeast comprises at least ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27817"
] | [
"Ies1_helical"
] | [
59
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070373",
"PUB00162056"
] | [
"24297934",
"26340092"
] | [
"Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex.",
"Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability."
] | [
2013,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
59
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Ino eighty subunit 1, helical domain | Ino eighty subunit 1, helical domain | Ies1_helical | 4 |
IPR060632 | 60,632 | CACHD1, C-terminal domain | CACHD1_C | Domain | 1,815 | false | false | This entry represents the C-terminal domain of VWFA and cache domain-containing protein 1 (CACHD1). CACHD1 is a single-pass type I membrane protein that may regulate voltage-dependent calcium channels. The protein belongs to the calcium channel subunit alpha-2/delta family and is found in animals [ ]. CACHD1 contains a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27776"
] | [
"CACHD1_C"
] | [
1815
] | 1 | [] | [] | [] | 0 | [
"8s7c",
"9eq6"
] | 2 | [
"PUB00161840",
"PUB00161841"
] | [
"30181139",
"38158856"
] | [
"CACHD1 is an α2δ-Like Protein That Modulates Ca<sub>V</sub>3 Voltage-Gated Calcium Channel Activity.",
"Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalities."
] | [
2018,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1815
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
4,
2,
4
] | 5 | true | Domain | CACHD1, C-terminal domain | CACHD1, C-terminal domain | CACHD1_C | 2 |
IPR060633 | 60,633 | EID1-like F-box protein 1-3-like, C-terminal domain | EID1-3-like_C | Domain | 2,001 | false | false | This entry represents the C-terminal domain of EID1-like F-box 1-3 proteins from plants, including EID1, EDL1, EDL2 and EDL3 from Arabidopsis thaliana and related sequences. These proteins are components of SCF E3 ubiquitin ligase complexes. EID1 is a negative regulator of the phytochrome A signalling pathway and is in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27778"
] | [
"EID2_C"
] | [
2001
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161924"
] | [
"11316788"
] | [
"EID1, an F-box protein involved in phytochrome A-specific light signaling."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
2001
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
25,
19
] | 3 | true | Domain | EID1-like F-box protein 1-3-like, C-terminal domain | EID1-like F-box protein 1-3-like, C-terminal domain | EID1-3-like_C | 2 |
IPR060635 | 60,635 | Enhanced level of genomic instability 1 domain | ELG1_dom | Domain | 102 | false | false | This entry represents a domain found in enhanced level of genomic instability 1 (ELG1) from Drosophila melanogaster and similar fly proteins. ELG1 is the large subunit of the heteropentameric Elg1 RFC-like complex that regulates PCNA unloading from DNA during S phase, playing roles in DNA replication and genome integri... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28136"
] | [
"ELG1_middle"
] | [
102
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161931"
] | [
"27198229"
] | [
"The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Diptera"
] | [
102
] | 1 | [
"Drosophila melanogaster"
] | [
1
] | 1 | true | Domain | Enhanced level of genomic instability 1 domain | Enhanced level of genomic instability 1 domain | ELG1_dom | 3 |
IPR060638 | 60,638 | EvC complex member EVC, N-terminal domain | EVC_N | Domain | 1,172 | false | false | This entry represents the N-terminal domain of EvC complex member EVC and similar animal proteins. The specific function of this domain remains to be determined. EVC is a single-pass membrane protein that forms part of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC [ ]. The complex localises at the base of prim... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28139"
] | [
"EVC_N"
] | [
1172
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5632684",
"R-HSA-5635838",
"R-MMU-5632684"
] | [
"REACTOME:R-HSA-5632684",
"REACTOME:R-HSA-5635838",
"REACTOME:R-MMU-5632684"
] | 3 | [] | 0 | [
"PUB00060742",
"PUB00161945"
] | [
"10700184",
"24582806"
] | [
"Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.",
"EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia."
] | [
2000,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1172
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
4,
4
] | 4 | true | Domain | EvC complex member EVC, N-terminal domain | EvC complex member EVC, N-terminal domain | EVC_N | 7 |
IPR060639 | 60,639 | EvC complex member EVC, C-terminal domain | EVC_C | Domain | 1,080 | false | false | This entry represents the C-terminal cytoplasmic domain of EvC complex member EVC and similar animal proteins. This cytoplasmic domain likely mediates protein-protein interactions within the EvC complex, though its specific function remains to be determined. It contains some disordered regions and compositional bias re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28141"
] | [
"EVC_C"
] | [
1080
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5632684",
"R-HSA-5635838",
"R-MMU-5632684"
] | [
"REACTOME:R-HSA-5632684",
"REACTOME:R-HSA-5635838",
"REACTOME:R-MMU-5632684"
] | 3 | [] | 0 | [
"PUB00060742",
"PUB00161945"
] | [
"10700184",
"24582806"
] | [
"Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.",
"EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia."
] | [
2000,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1080
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4,
3
] | 4 | true | Domain | EvC complex member EVC, C-terminal domain | EvC complex member EVC, C-terminal domain | EVC_C | 4 |
IPR060640 | 60,640 | Arabinogalactan protein 13/21/23/40 | AGP13/21/23/40 | Family | 1,501 | false | false | Arabinogalactan proteins (AGPs) are proteoglycans of the plant extracellular matrix that have been implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death. This entry includes AGP13 ,AGP21 ,AGP23 (At3g57690) and AGP40 (At3g20865) from Arabidopsis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28140"
] | [
"AGP40"
] | [
1501
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00096875",
"PUB00161782",
"PUB00162531"
] | [
"15322080",
"12177459",
"25053647"
] | [
"Post-translational modifications of arabinogalactan-peptides of Arabidopsis thaliana. Endoplasmic reticulum and glycosylphosphatidylinositol-anchor signal cleavage sites and hydroxylation of proline.",
"Using genomic resources to guide research directions. The arabinogalactan protein gene family as a test case."... | [
2004,
2002,
2014
] | 3 | [] | [
"IPR044702"
] | 0 | 1 | 0 | [
"Embryophyta"
] | [
1501
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
4,
10
] | 3 | true | Family | Arabinogalactan protein 13/21/23/40 | Arabinogalactan protein 13/21/23/40 | AGP13/21/23/40 | 5 |
IPR060641 | 60,641 | SPBC1E8.03c, N-terminal domain | SPBC1E8_03c_N | Domain | 1,250 | false | false | This entry represents the N-terminal domain of SPBC1E8.03c, an uncharacterised protein from Schizosaccharomyces pombe. This domain adopts a Rossmann fold structure. SPBC1E8.03c is a 550-amino acid glycoprotein localised to the endoplasmic reticulum [ ]. The protein contains a signal peptide and two N-linked glycosylati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28142"
] | [
"SPBC1E8_03c_N"
] | [
1250
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053363"
] | [
"16823372"
] | [
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1250
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | SPBC1E8.03c, N-terminal domain | SPBC1E8.03c, N-terminal domain | SPBC1E8_03c_N | 2 |
IPR060642 | 60,642 | SPBC1E8.03c, C-terminal domain | SPBC1E8_03c_C | Domain | 8 | false | false | This entry represents the C-terminal domain of SPBC1E8.03c, an uncharacterised protein from Schizosaccharomyces pombe. This domain adopts a glycosyltransferase fold structure. SPBC1E8.03c is a 550-amino acid glycoprotein localised to the endoplasmic reticulum [ ]. The protein contains a signal peptide and two N-linked ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28143"
] | [
"SPBC1E8_03c_C"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053363"
] | [
"16823372"
] | [
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Domain | SPBC1E8.03c, C-terminal domain | SPBC1E8.03c, C-terminal domain | SPBC1E8_03c_C | 9 |
IPR060643 | 60,643 | MAP3K12-binding inhibitory protein 1, N-terminal domain | MBIP_N | Domain | 1,133 | false | false | This entry represents the N-terminal domain of MAP3K12-binding inhibitory protein 1 (MBIP) and similar proteins from vertebrates. MBIP inhibits MAP3K12 activity and thereby prevents activation of the JNK/SAPK pathway [ ]. It is a component of the ATAC complex, which has histone acetyltransferase activity on histones H3... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27820"
] | [
"MBIP_N"
] | [
1133
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-9772755",
"R-MMU-9772755"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-9772755"
] | 3 | [] | 0 | [
"PUB00044665",
"PUB00053704"
] | [
"10801814",
"19103755"
] | [
"MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase.",
"The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
] | [
2000,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1133
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
1,
3
] | 4 | true | Domain | MAP3K12-binding inhibitory protein 1, N-terminal domain | MAP3K12-binding inhibitory protein 1, N-terminal domain | MBIP_N | 6 |
IPR060644 | 60,644 | Proheparin-binding EGF-like growth factor, C-terminal domain | HBEGF_C | Domain | 1,364 | false | false | This entry represents the C-terminal domain of Proheparin-binding EGF-like growth factor (HBEGF) and similar proteins from vertebrates. HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4 receptors and promotes smooth muscle cell proliferation. The full-length protein is initially synthesised a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27818"
] | [
"HBEGF_C"
] | [
1364
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-1227986",
"R-GGA-1236394",
"R-GGA-1250196",
"R-GGA-1250342",
"R-GGA-1250347",
"R-GGA-1257604",
"R-GGA-177929",
"R-GGA-179812",
"R-GGA-180292",
"R-GGA-180336",
"R-GGA-182971",
"R-GGA-1963640",
"R-GGA-1963642",
"R-GGA-212718",
"R-GGA-2179392",
"R-GGA-5673001",
"R-GGA-6785631",
... | [
"REACTOME:R-GGA-1227986",
"REACTOME:R-GGA-1236394",
"REACTOME:R-GGA-1250196",
"REACTOME:R-GGA-1250342",
"REACTOME:R-GGA-1250347",
"REACTOME:R-GGA-1257604",
"REACTOME:R-GGA-177929",
"REACTOME:R-GGA-179812",
"REACTOME:R-GGA-180292",
"REACTOME:R-GGA-180336",
"REACTOME:R-GGA-182971",
"REACTOME:R-G... | 126 | [] | 0 | [
"PUB00161997"
] | [
"1445231"
] | [
"Tissue distribution of mRNA for heparin-binding epidermal growth factor."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1364
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
2
] | 4 | true | Domain | Proheparin-binding EGF-like growth factor, C-terminal domain | Proheparin-binding EGF-like growth factor, C-terminal domain | HBEGF_C | 5 |
IPR060647 | 60,647 | DLEC1, sixth Ig-like domain | Ig_DLEC1_6th | Domain | 1,315 | false | false | This domain is found in Deleted in lung and esophageal cancer protein 1 DLEC1 from human and related proteins. This protein is essential for spermatogenesis and male fertility and may play a role in the sperm head and tail formation [ ]. This entry represents the 6th Ig-like domain of human DLEC1. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23316"
] | [
"Ig_DLEC1_6th"
] | [
1315
] | 1 | [] | [] | [] | 0 | [
"9ijj"
] | 1 | [
"PUB00155671"
] | [
"33144677"
] | [
"Dlec1 is required for spermatogenesis and male fertility in mice."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1315
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
3,
2,
4
] | 4 | true | Domain | DLEC1, sixth Ig-like domain | DLEC1, sixth Ig-like domain | Ig_DLEC1_6th | 2 |
IPR060648 | 60,648 | Glycyl-tRNA synthetase, insertion domain 1 | GlyRS_ins_1 | Domain | 4,346 | false | false | This entry represents an insertion domain of approximately 80-85 residues found in dimeric glycyl-tRNA synthetases from Thermus thermophilus and related organisms. This domain is uniquely inserted between sequence motifs 1 and 2 of the class II synthetase catalytic domain and is positioned above the active site. The do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28494"
] | [
"GlyRS_ins_1"
] | [
4346
] | 1 | [
"EC"
] | [
"6.1.1.14"
] | [
"EC:6.1.1.14"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4273,
21,
52
] | 3 | [] | [] | 0 | true | Domain | Glycyl-tRNA synthetase, insertion domain 1 | Glycyl-tRNA synthetase, insertion domain 1 | GlyRS_ins_1 | 5 |
IPR060650 | 60,650 | Rho guanine nucleotide exchange factor 40-like, N-terminal domain | ARHGEF40-like_N | Domain | 3,102 | false | false | This entry represents the N-terminal domain of human Rho guanine nucleotide exchange factor 40 (ARHGEF40), Pleckstrin homology domain-containing family G member 4B (PLEKHG4B), the uncharacterised protein KIAA1755 and similar animal proteins. ARHGEF40 promotes actin stress fibre formation, force-induced stress fibre rei... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27628"
] | [
"KIAA1755_N"
] | [
3102
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-8980692",
"R-HSA-9013106",
"R-HSA-9013148"
] | [
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013106",
"REACTOME:R-HSA-9013148"
] | 5 | [] | 0 | [
"PUB00162113",
"PUB00162535",
"PUB00162536",
"PUB00163212"
] | [
"11214970",
"26823019",
"30929300",
"33310911"
] | [
"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.",
"Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.",
"Keratin-binding ability of... | [
2000,
2016,
2019,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3102
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
31,
2,
9,
7,
7
] | 5 | true | Domain | Rho guanine nucleotide exchange factor 40-like, N-terminal domain | Rho guanine nucleotide exchange factor 40-like, N-terminal domain | ARHGEF40-like_N | 5 |
IPR060651 | 60,651 | Rho guanine nucleotide exchange factor 40-like, C-terminal domain | ARHGEF40-like_C | Domain | 2,359 | false | false | This entry represents the C-terminal of human Rho guanine nucleotide exchange factor 40 (ARHGEF40), the uncharacterised protein KIAA1755 and similar animal proteins. ARHGEF40 promotes actin stress fibre formation, force-induced stress fibre reinforcement and organisation of KRT8/KRT18 networks via activation of RHOA/RO... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27632"
] | [
"KIAA1755_C"
] | [
2359
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-193648",
"R-HSA-416482",
"R-HSA-8980692",
"R-HSA-9013106",
"R-HSA-9013148",
"R-HSA-9013149"
] | [
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013106",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149"
] | 6 | [] | 0 | [
"PUB00162113",
"PUB00162535",
"PUB00162536"
] | [
"11214970",
"26823019",
"30929300"
] | [
"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.",
"Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.",
"Keratin-binding ability of... | [
2000,
2016,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2359
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
47,
6,
9,
16
] | 4 | true | Domain | Rho guanine nucleotide exchange factor 40-like, C-terminal domain | Rho guanine nucleotide exchange factor 40-like, C-terminal domain | ARHGEF40-like_C | 1 |
IPR060652 | 60,652 | RCAS1, C-terminal | RCAS1_C | Domain | 1,054 | false | false | This entry represents the C-terminal region of RCAS1 proteins, also known as EBAG9 (Estrogen receptor-binding fragment-associated gene 9), found in mammals. RCAS1 proteins are approximately 213 amino acids in length and contain a single-pass type III transmembrane domain and a C-terminal coiled-coil domain. The protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28220"
] | [
"RCAS1_C"
] | [
1054
] | 1 | [
"REACTOME"
] | [
"R-HSA-9018519"
] | [
"REACTOME:R-HSA-9018519"
] | 1 | [] | 0 | [
"PUB00044066",
"PUB00162272",
"PUB00162273"
] | [
"11374862",
"10426319",
"12672804"
] | [
"Molecular cloning and characterization of mouse EBAG9, homolog of a human cancer associated surface antigen: expression and regulation by estrogen.",
"Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1.",
"The Golgi protein RCAS1 controls cell surface ex... | [
2001,
1999,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1054
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
4
] | 4 | true | Domain | RCAS1, C-terminal | RCAS1, C-terminal | RCAS1_C | 1 |
IPR060654 | 60,654 | 3-deoxy-D-manno-octulosonic acid transferase WaaZ | WaaZ_KDO_III | Family | 1,743 | false | false | This entry represents WaaZ, also known as Kdo-III transferase and related proteins from proteobacteria. This family is related to . WaaZ is present in some strains of E. coli and its allies but not others, performs a non-stoichiometric addition of a third 3-deoxy-D-manno-oct-2-ulosonic acid (KDO-III) onto some fraction... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27901"
] | [
"WaaZ_KDO_III"
] | [
1743
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074359"
] | [
"22021036"
] | [
"Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose."
] | [
2011
] | 1 | [] | [
"IPR031026"
] | 0 | 1 | 0 | [
"Bacteria",
"Rhizopus delemar",
"marine sediment metagenome"
] | [
1741,
1,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 3-deoxy-D-manno-octulosonic acid transferase WaaZ | 3-deoxy-D-manno-octulosonic acid transferase WaaZ | WaaZ_KDO_III | 6 |
IPR060655 | 60,655 | LOC1, C-terminal | LOC1_helical | Domain | 1,175 | false | false | This entry represents the helical region found at the C-terminal of LOC1 proteins. This is coiled-coil region and is found in fungi, particularly Ascomycota. While the full-length LOC1 protein has established roles in ribosomal assembly, the specific function of this helical region remains to be determined. Loc1 is req... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28225"
] | [
"LOC1_helical"
] | [
1175
] | 1 | [] | [] | [] | 0 | [
"7nac",
"7r6k",
"7r7a",
"7r7c",
"8i9r",
"8i9t",
"8i9v",
"8i9w",
"8i9x",
"8i9y",
"8i9z",
"8ia0",
"8v83",
"8v84",
"8v87"
] | 15 | [
"PUB00087444",
"PUB00087445",
"PUB00087446"
] | [
"16871394",
"27458021",
"11309412"
] | [
"Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit.",
"The Roles of Puf6 and Loc1 in 60S Biogenesis Are Interdependent, and Both Are Required for Efficient Accommodation of Rpl43.",
"An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA an... | [
2006,
2016,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1175
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | LOC1, C-terminal | LOC1, C-terminal | LOC1_helical | 9 |
IPR060656 | 60,656 | IgSF3/IGSF8/FPRP, immunoglobulin-like domain | Ig_IgSF3/IGSF8/FPRP | Domain | 2,158 | false | false | This immunoglobulin-like (Ig-like) domain is found in human Immunoglobulin superfamily member 3 (IgSF3), Immunoglobulin superfamily member 8 (IGSF8), Prostaglandin F2 receptor negative regulator (FPRP) and similar proteins. IGSF8 links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several import... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28276"
] | [
"Ig_IgSF3"
] | [
2158
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00045010",
"PUB00162079",
"PUB00162080",
"PUB00162081",
"PUB00162082",
"PUB00162083",
"PUB00162084",
"PUB00162085",
"PUB00162086",
"PUB00162087",
"PUB00162088",
"PUB00162089"
] | [
"12752121",
"32573489",
"31560140",
"23575678",
"11673522",
"16203089",
"38657602",
"11504738",
"12750295",
"14662754",
"15070678",
"17785435"
] | [
"Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.",
"IGSF3 mutation identified in patient with severe COPD alters cell function and motility.",
"Osteoclastogenesis inhibition by mutated IGSF23 results in human osteopetrosis.",
"Normal muscle regeneration requir... | [
2003,
2020,
2019,
2013,
2001,
2006,
2024,
2001,
2003,
2003,
2004,
2007
] | 12 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
2158
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
8,
10,
9
] | 4 | true | Domain | IgSF3/IGSF8/FPRP, immunoglobulin-like domain | IgSF3/IGSF8/FPRP, immunoglobulin-like domain | Ig_IgSF3/IGSF8/FPRP | 1 |
IPR060657 | 60,657 | NNF2-like, helical region | NNF2_helical | Domain | 1,100 | false | false | This entry represents a helical region found towards the C-terminal of NNF2 proteins. NNF2 is an endoplasmic reticulum membrane protein found in fungi, particularly in Saccharomyces cerevisiae where it localises to the ER membrane as a multi-pass transmembrane protein. The protein contains multiple transmembrane helice... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28337"
] | [
"NNF2_middle"
] | [
1100
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162058"
] | [
"18394190"
] | [
"Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1100
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | NNF2-like, helical region | NNF2-like, helical region | NNF2_helical | 4 |
IPR060658 | 60,658 | pH-response transcription factor PacC/RIM101, C-terminal | PacC_helical | Domain | 1,151 | false | false | This entry represents the C-terminal region of pH-response transcription factor pacC/RIM101. PacC is a transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH [ , ]. At alkaline ambient pH, PacC activates transcription of alkaline-expressed genes and represses ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28334"
] | [
"PacC_helical"
] | [
1151
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00087079",
"PUB00162214"
] | [
"7628696",
"7882981"
] | [
"Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.",
"The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH."
] | [
1995,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1151
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | pH-response transcription factor PacC/RIM101, C-terminal | pH-response transcription factor PacC/RIM101, C-terminal | PacC_helical | 4 |
IPR060660 | 60,660 | Semaphorin-3/4/7A-like, immunoglobulin-like domain | Ig_SEMA33/4/7A | Domain | 8,701 | false | false | This immunoglobulin-like (Ig-like) domain is found in human Semaphorin-3/4/7A (SEMA3/4/7A) and similar sequences. SEMA3F may play a role in cell motility and cell adhesion. SEMA4A is a cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signalling [ ] and it also regula... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28354"
] | [
"Ig_SEMA7A"
] | [
8701
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-416700",
"R-MMU-416550",
"R-MMU-416572",
"R-MMU-416700"
] | [
"REACTOME:R-HSA-416700",
"REACTOME:R-MMU-416550",
"REACTOME:R-MMU-416572",
"REACTOME:R-MMU-416700"
] | 4 | [
"3nvq"
] | 1 | [
"PUB00091404",
"PUB00126742",
"PUB00126746",
"PUB00126935",
"PUB00126940",
"PUB00126943",
"PUB00127324",
"PUB00127328",
"PUB00127356",
"PUB00162093",
"PUB00162094",
"PUB00162095",
"PUB00162096",
"PUB00162537",
"PUB00162538"
] | [
"20877282",
"16055703",
"19788569",
"17377534",
"17671519",
"12879062",
"17021275",
"11688556",
"17498836",
"15239958",
"22956603",
"8876214",
"15811348",
"39881190",
"29981480"
] | [
"Structural basis of semaphorin-plexin signalling.",
"Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.",
"The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neuron... | [
2010,
2005,
2009,
2007,
2008,
2003,
2007,
2001,
2007,
2004,
2012,
1996,
2005,
2025,
2018
] | 15 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Testudinid alphaherpesvirus 3"
] | [
8700,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
48,
24,
12,
24
] | 4 | true | Domain | Semaphorin-3/4/7A-like, immunoglobulin-like domain | Semaphorin-3/4/7A-like, immunoglobulin-like domain | Ig_SEMA33/4/7A | 7 |
IPR060661 | 60,661 | DRC9/10, N-terminal domain | DRC9/10_N | Domain | 2,361 | false | false | This entry represents the N-terminal domain of dynein regulatory complex protein 9/10 (DRC9/10) and similar proteins mainly found in animals. DRC9/10 are components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary and flagellar motility which maintains the alignment and integrity of the distal... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27661"
] | [
"DRC10_N"
] | [
2361
] | 1 | [] | [] | [] | 0 | [
"8glv",
"8j07",
"8th8",
"8tid",
"9e5c",
"9fqr"
] | 6 | [
"PUB00089658",
"PUB00093373"
] | [
"25411337",
"23427265"
] | [
"Detailed structural and biochemical characterization of the nexin-dynein regulatory complex.",
"The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes."
] | [
2015,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2361
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
3,
7
] | 4 | true | Domain | DRC9/10, N-terminal domain | DRC9/10, N-terminal domain | DRC9/10_N | 6 |
IPR060662 | 60,662 | COBRA, N-terminal domain | COBRA_N | Domain | 6,172 | false | false | This entry represents the N-terminal domain of COBRA family proteins. In Arabidopsis thaliana, members of the family are all extracellular glycosyl-phosphatidyl inositol-anchored proteins (GPI-linked) [ ]. COBRA is involved in determining the orientation of cell expansion, probably by playing an important role in cellu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04833"
] | [
"COBRA"
] | [
6172
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044727",
"PUB00044935"
] | [
"15849274",
"12376623"
] | [
"COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation.",
"The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion."
] | [
2005,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
6172
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
45,
25,
46
] | 3 | true | Domain | COBRA, N-terminal domain | COBRA, N-terminal domain | COBRA_N | 7 |
IPR060663 | 60,663 | Retinitis pigmentosa 9 protein, N-terminal | RP9_N | Domain | 440 | false | false | This entry represents the N-terminal helix of RP9 proteins, also known as Pim-1-associated protein. RP9 is thought to be a target protein for the PIM1 kinase and may play roles in B-cell proliferation [ ]. The protein is nuclear localised and interacts with PIM1 and ZNHIT4. This N-terminal region contains the PIM1 bind... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28352"
] | [
"RP9_N"
] | [
440
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083748",
"PUB00083751"
] | [
"12032732",
"10931201"
] | [
"Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa.",
"PAP-1, a novel target protein of phosphorylation by pim-1 kinase."
] | [
2002,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
440
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
6
] | 3 | true | Domain | Retinitis pigmentosa 9 protein, N-terminal | Retinitis pigmentosa 9 protein, N-terminal | RP9_N | 5 |
IPR060664 | 60,664 | Retinitis pigmentosa 9 protein, C-terminal | RP9_C | Domain | 918 | false | false | This entry represents the C-terminal region of retinitis pigmentosa 9 protein (RP9), also known as Pim-1-associated protein (PAP-1). The full-length protein is found in mammals and is localised to the nucleus. RP9 is thought to be a target protein for the PIM1 kinase and may play roles in B-cell proliferation [ ]. The ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28369"
] | [
"RP9_C"
] | [
918
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00083748",
"PUB00083751"
] | [
"12032732",
"10931201"
] | [
"Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa.",
"PAP-1, a novel target protein of phosphorylation by pim-1 kinase."
] | [
2002,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
918
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
6,
6
] | 4 | true | Domain | Retinitis pigmentosa 9 protein, C-terminal | Retinitis pigmentosa 9 protein, C-terminal | RP9_C | 3 |
IPR060665 | 60,665 | At5g65660-like, transmembrane helix | At5g65660_TM | Domain | 1,076 | false | false | This entry represents a helical region found at the N-terminal of At5g65660 from Arabidopsis thaliana and similar proteins from plants. The prototype protein At5g65660 from Arabidopsis thaliana is a 136-amino acid uncharacterised membrane protein containing a predicted transmembrane helix (residues 19-39) and extensive... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28413"
] | [
"At5g65660_helical"
] | [
1076
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1076
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
4,
5
] | 3 | true | Domain | At5g65660-like, transmembrane helix | At5g65660-like, transmembrane helix | At5g65660_TM | 9 |
IPR060666 | 60,666 | SKA3, N-terminal | SKA3_N | Domain | 694 | false | false | This entry represents the short N-terminal helix of SKA complex subunit 3, whose function is unknown. The SKA complex is an essential mitotic component required for accurate cell division in human cells. It is a microtubule plus end-binding complex of the outer kinetochore that stabilises spindle microtubule-kinetochor... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28418"
] | [
"SKA3_N"
] | [
694
] | 1 | [] | [] | [] | 0 | [
"4aj5"
] | 1 | [
"PUB00061772",
"PUB00077598",
"PUB00078502",
"PUB00078505"
] | [
"19289083",
"23085020",
"19646878",
"19360002"
] | [
"The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility.",
"The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.",
"Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis."... | [
2009,
2012,
2009,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
694
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
1,
3
] | 4 | true | Domain | SKA3, N-terminal | SKA3, N-terminal | SKA3_N | 5 |
IPR060667 | 60,667 | CRISPR-associated endoribonuclease Cas13a, N-terminal | Cas13a_endoribonuclease_N | Domain | 64 | false | false | This is the N-terminal domain of CRISPR-associated endoribonucleases known as Cas13a which are involved in the CRISPR adaptive immune system, which provides defense against mobile genetic elements such as viruses, transposable elements, and conjugative plasmids. Cas13a is part of the type VI-A CRISPR-Cas system and fun... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28192"
] | [
"Cas13a_endoribonuclease"
] | [
64
] | 1 | [] | [] | [] | 0 | [
"5w1h",
"5w1i",
"5wlh",
"5wtj",
"5wtk",
"5xwp",
"5xwy",
"6vrb",
"6vrc",
"7dmq",
"7os0",
"8ewg",
"8h4u",
"8zty"
] | 14 | [
"PUB00105601"
] | [
"27669025"
] | [
"Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenome"
] | [
63,
1
] | 2 | [] | [] | 0 | true | Domain | CRISPR-associated endoribonuclease Cas13a, N-terminal | CRISPR-associated endoribonuclease Cas13a, N-terminal | Cas13a_endoribonuclease_N | 9 |
IPR060669 | 60,669 | PF3D7_0210200, C-terminal domain | PF3D7_0210200_C | Domain | 71 | false | false | This entry represents the C-terminal domain of Plasmodium falciparum protein PF3D7_0210200 and related proteins. The domain adopts a helix hairpin structure. The full-length protein is 2588 amino acids and contains predicted coiled-coil regions and multiple disordered regions. The protein is localised to the merozoite,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27589"
] | [
"PF3D7_0210200_C"
] | [
71
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162224"
] | [
"17653272"
] | [
"Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
71
] | 1 | [] | [] | 0 | true | Domain | PF3D7_0210200, C-terminal domain | PF3D7_0210200, C-terminal domain | PF3D7_0210200_C | 4 |
IPR060670 | 60,670 | PEX8-like, central TPR-like domain | PEX8_TPR_mid | Domain | 1,987 | false | false | This entry represents a TPR-like domain found in PEX8 and related eukaryotic peroxisomal membrane proteins. PEX8 proteins are essential components of the machinery required for the import of peroxisomal matrix proteins [ ]. PEX8 binding to the N-terminal region of the PEX5 cargo receptor induces conformational changes ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27812"
] | [
"PEX8_TPR_mid"
] | [
1987
] | 1 | [] | [] | [] | 0 | [
"8rqt"
] | 1 | [
"PUB00155361",
"PUB00155362"
] | [
"23902771",
"7738036"
] | [
"Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.",
"PER3, a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import."
] | [
2013,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1987
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Zea mays"
] | [
6,
1,
3
] | 3 | true | Domain | PEX8-like, central TPR-like domain | PEX8-like, central TPR-like domain | PEX8_TPR_mid | 8 |
IPR060671 | 60,671 | EVI2B, conserved region | EVI2B_conserved | Domain | 570 | false | false | This entry covers the most highly conserved region of the proteins. It includes a potential transmembrane helix. EVI2B is a gene lying within an intron of the neurofibromatosis type 1 (NF1) gene [ ]. As NF1, it might be involved in differentiation of melanocytes and keratinocytes [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27913"
] | [
"EVI2B"
] | [
570
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078246",
"PUB00078247"
] | [
"10360836",
"1903357"
] | [
"EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas.",
"cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofib... | [
1999,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
570
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
2
] | 4 | true | Domain | EVI2B, conserved region | EVI2B, conserved region | EVI2B_conserved | 8 |
IPR060672 | 60,672 | Anti-phage protein ZorA-like | ZorA-like | Family | 561 | false | false | This family includes anti-phage ZorA-like proteins found in bacteria. ZorA is a component of the antiviral defense Zorya type I system, composed of ZorA, ZorB, ZorC, and ZorD. The expression of Zorya type I system in E.coli (strain MG1655) confers resistance to phages SECphi7, lambda, and T7 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28082"
] | [
"ZorA-like_t1"
] | [
561
] | 1 | [] | [] | [] | 0 | [
"8qyd",
"8qyh",
"8qyk",
"8qyy",
"8vvn"
] | 5 | [
"PUB00097806"
] | [
"29371424"
] | [
"Systematic discovery of antiphage defense systems in the microbial pangenome."
] | [
2018
] | 1 | [] | [
"IPR049670"
] | 0 | 1 | 0 | [
"Bacteria",
"bioreactor metagenome"
] | [
560,
1
] | 2 | [] | [] | 0 | true | Family | Anti-phage protein ZorA-like | Anti-phage protein ZorA-like | ZorA-like | 4 |
IPR060673 | 60,673 | HrpV-like, gammaproteobacteria | HrpV | Family | 365 | false | false | This entry represents HrpV from Erwinia amylovora and similar proteins from the type III secretion system protein (T3SS) found in gammaproteobacteria [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28066"
] | [
"HrpV"
] | [
365
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044769"
] | [
"9045830"
] | [
"The hrpA and hrpC operons of Erwinia amylovora encode components of a type III pathway that secretes harpin."
] | [
1997
] | 1 | [] | [
"IPR048206"
] | 0 | 1 | 0 | [
"Pseudomonadota"
] | [
365
] | 1 | [] | [] | 0 | true | Family | HrpV-like, gammaproteobacteria | HrpV-like, gammaproteobacteria | HrpV | 4 |
IPR060674 | 60,674 | Qat anti-phage system associated protein QatB | QatB | Family | 862 | false | false | This entry represents the QatB family of proteins. Members of this family are components of the Qat anti-phage system (QueC-like associated with ATPase and TatD DNase) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28083"
] | [
"QatB"
] | [
862
] | 1 | [] | [] | [] | 0 | [
"9y01",
"9y02"
] | 2 | [
"PUB00152882"
] | [
"32855333"
] | [
"Diverse enzymatic activities mediate antiviral immunity in prokaryotes."
] | [
2020
] | 1 | [] | [
"IPR049675"
] | 0 | 1 | 0 | [
"Bacteria",
"Bilateria",
"Pasteurella phage vB_PmuM_CFP3",
"metagenomes"
] | [
847,
2,
1,
12
] | 4 | [] | [] | 0 | true | Family | Qat anti-phage system associated protein QatB | Qat anti-phage system associated protein QatB | QatB | 8 |
IPR060681 | 60,681 | Protein LIAT1, helical region | LIAT1_helical | Domain | 451 | false | false | This entry represents a conserved helix found in the middle of LIAT1 proteins. Its function is unknown. This entry includes LIAT1 (ligand of Ate1) from animals. LIAT1 interacts with Ate1 and may be involved in Ate1-mediated N-terminal arginylation. Ate1 is a component of the N-end rule pathway, which recognises and pol... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27950"
] | [
"LIAT1"
] | [
451
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088432"
] | [
"25369936"
] | [
"Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
451
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
2
] | 4 | true | Domain | Protein LIAT1, helical region | Protein LIAT1, helical region | LIAT1_helical | 8 |
IPR060682 | 60,682 | Spermatogenesis-associated protein 45 | SPATA45 | Family | 288 | false | false | The function of spermatogenesis-associated protein 45 is not clear. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27952"
] | [
"SPATA45"
] | [
288
] | 1 | [] | [] | [] | 0 | [
"8snb"
] | 1 | [] | [] | [] | [] | 0 | [] | [
"IPR038806"
] | 0 | 1 | 0 | [
"Metazoa"
] | [
288
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
1,
3
] | 4 | true | Family | Spermatogenesis-associated protein 45 | Spermatogenesis-associated protein 45 | SPATA45 | 9 |
IPR060683 | 60,683 | AT hook-containing protein attf-4, conserved domain | Attf-4_dom | Domain | 151 | false | false | This entry represents a conserved domain found in a group of proteins from nematodes, including Attf-4. Their function is not clear. It may adopt an helical bundle fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27957"
] | [
"Attf-4-like"
] | [
151
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
151
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | AT hook-containing protein attf-4, conserved domain | AT hook-containing protein attf-4, conserved domain | Attf-4_dom | 9 |
IPR060687 | 60,687 | Uncharacterised conserved protein UCP026610-like | UCP026610-like | Family | 909 | false | false | This entry represents a family of uncharacterised proteins from actinomycetes that are predicted to adopt a PH-like fold which has two transmembrane helices inserted into the PH domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27726"
] | [
"UCP026610"
] | [
909
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR016844"
] | 0 | 1 | 0 | [
"Actinomycetes",
"freshwater metagenome"
] | [
907,
2
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP026610-like | Uncharacterised conserved protein UCP026610-like | UCP026610-like | 5 |
IPR060689 | 60,689 | Ucp12-like, UBA domain | UBA_Ucp12 | Domain | 1,214 | false | false | This UBA domain is found C-terminal to in the putative ATP-dependent RNA helicase ucp12 from Schizosaccharomyces pombe and similar proteins mainly found in yeast. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27606"
] | [
"UBA_Ucp12"
] | [
1214
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Thiomicrospira aerophila AL3"
] | [
1213,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Ucp12-like, UBA domain | Ucp12-like, UBA domain | UBA_Ucp12 | 5 |
IPR060693 | 60,693 | Trehalose monomycolate transport factor TtfA | Treh_trans_TtfA | Family | 1,093 | false | false | This family represents the trehalose monomycolate transport factor A (TtfA) which is required for the transport of trehalose monomycolate across the inner membrane, potentially by forming a complex with the atypical lipid transporter MmpL3. Trehalose monomycolate is a component of the mycobacterial envelope. The core d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28092"
] | [
"Treh_trans_TtfA"
] | [
1093
] | 1 | [] | [] | [] | 0 | [
"6t84"
] | 1 | [
"PUB00106286",
"PUB00106287"
] | [
"31239378",
"31833106"
] | [
"Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.",
"The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold."
] | [
2019,
2020
] | 2 | [] | [
"IPR049724"
] | 0 | 1 | 0 | [
"Actinomycetes",
"freshwater metagenome"
] | [
1092,
1
] | 2 | [] | [] | 0 | true | Family | Trehalose monomycolate transport factor TtfA | Trehalose monomycolate transport factor TtfA | Treh_trans_TtfA | 6 |
IPR060695 | 60,695 | HetZ-like | HetZ-like | Family | 692 | false | false | This entry represents HetZ, a heterocyst differentiation protein from Anabaena sp., and related proteins found mainly in cyanobacteria [ , ]. HetZ is among the most important factors involved in heterocyst differentiation [ ]. HetZ functions in the patterning stage of differentiation. Deletion of hetZ fails to express ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28104"
] | [
"HetZ"
] | [
692
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105486",
"PUB00105487",
"PUB00105488",
"PUB00105489"
] | [
"18045384",
"22389489",
"29440250",
"29676808"
] | [
"A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120.",
"Identification of the HetR recognition sequence upstream of hetZ in Anabaena sp. strain PCC 7120.",
"Functional Overlap of hetP and hetZ in Regulation of Heterocyst Differentiation in Anabaen... | [
2007,
2012,
2018,
2018
] | 4 | [] | [
"IPR048033",
"IPR049778",
"IPR049910"
] | 0 | 3 | 0 | [
"Cyanobacteriota"
] | [
692
] | 1 | [] | [] | 0 | true | Family | HetZ-like | HetZ-like | HetZ-like | 8 |
IPR060696 | 60,696 | Probable transporter, periplasmic core domain | PCD-like | Domain | 639 | false | false | This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a globular structure with a significant similarity to the periplasmic core domain of proteins members of the MacB ABC transporter superfamily. This domain contains the porter and sabre subdomains which are structurally similar to t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28560"
] | [
"PCD-like"
] | [
639
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
619,
20
] | 2 | [] | [] | 0 | true | Domain | Probable transporter, periplasmic core domain | Probable transporter, periplasmic core domain | PCD-like | 7 |
IPR060697 | 60,697 | Epigen, C-terminal transmembrane region | Epigen_C | Domain | 802 | false | false | This entry represents the C-terminal transmembrane region of epigen, a growth factor protein that promotes the growth of epithelial cells. The specific function of this C-terminal domain remains to be determined. Epigen is a member of the epidermal growth factor superfamily and functions as a ligand for ErbB receptors.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28398"
] | [
"Epigen_C"
] | [
802
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-1257604",
"R-GGA-177929",
"R-GGA-179812",
"R-GGA-180292",
"R-GGA-180336",
"R-GGA-182971",
"R-GGA-212718",
"R-GGA-5673001",
"R-GGA-6811558",
"R-GGA-8856825",
"R-GGA-8856828",
"R-GGA-9009391",
"R-HSA-1257604",
"R-HSA-177929",
"R-HSA-179812",
"R-HSA-180292",
"R-HSA-180336",
"R-... | [
"REACTOME:R-GGA-1257604",
"REACTOME:R-GGA-177929",
"REACTOME:R-GGA-179812",
"REACTOME:R-GGA-180292",
"REACTOME:R-GGA-180336",
"REACTOME:R-GGA-182971",
"REACTOME:R-GGA-212718",
"REACTOME:R-GGA-5673001",
"REACTOME:R-GGA-6811558",
"REACTOME:R-GGA-8856825",
"REACTOME:R-GGA-8856828",
"REACTOME:R-GG... | 39 | [] | 0 | [
"PUB00161936",
"PUB00161937"
] | [
"15611079",
"11278323"
] | [
"Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.",
"Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily."
] | [
2005,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
802
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
2
] | 3 | true | Domain | Epigen, C-terminal transmembrane region | Epigen, C-terminal transmembrane region | Epigen_C | 3 |
IPR060698 | 60,698 | DNAJC15, N-terminal transmembrane region | DNAJC15_N | Domain | 874 | false | false | This entry represents the N-terminal transmembrane region of DNAJC15 (DnaJ homolog subfamily C member 15) found in metazoa. DNAJC15 is a mitochondrial inner membrane protein that acts as a negative regulator of the mitochondrial respiratory chain and prevents mitochondrial hyperpolarisation [ ]. The protein functions a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28356"
] | [
"DNAJC15_N"
] | [
874
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161907",
"PUB00161908"
] | [
"23530063",
"23263864"
] | [
"MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.",
"Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria."
] | [
2013,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
874
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
6
] | 4 | true | Domain | DNAJC15, N-terminal transmembrane region | DNAJC15, N-terminal transmembrane region | DNAJC15_N | 9 |
IPR060699 | 60,699 | RNA-binding protein 48, helix domain | RBM48_helix | Domain | 941 | false | false | This entry represents the single helix domain of RNA-binding protein 48 (RBM48), located adjacent to the N-terminal RRM domain. RBM48 is a component of the minor spliceosome involved in the splicing of U12-type introns in pre-mRNAs [ ]. The protein interacts with ARMC7 and PRPF8 within the spliceosomal complex. RBM48 c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28333"
] | [
"RBM48_helical"
] | [
941
] | 1 | [] | [] | [] | 0 | [
"7dvq"
] | 1 | [
"PUB00100633"
] | [
"33509932"
] | [
"Structure of the activated human minor spliceosome."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
941
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
2,
5
] | 4 | true | Domain | RNA-binding protein 48, helix domain | RNA-binding protein 48, helix domain | RBM48_helix | 1 |
IPR060700 | 60,700 | Type III secretion systems effector SseF/SseG | SseF_SseG | Family | 1,272 | false | false | This entry represents a group of uncharacterised Type III secretion systems effector SseF/SseG proteins from Salmonella species. SseF and SseG are involved in the aggregation of the host endosomes [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28311"
] | [
"SseF"
] | [
1272
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161091"
] | [
"29610274"
] | [
"The <i>Salmonella</i> effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication."
] | [
2018
] | 1 | [] | [
"IPR058222",
"IPR058223"
] | 0 | 2 | 0 | [
"Pseudomonadota"
] | [
1272
] | 1 | [] | [] | 0 | true | Family | Type III secretion systems effector SseF/SseG | Type III secretion systems effector SseF/SseG | SseF_SseG | 7 |
IPR060701 | 60,701 | BV97_02767-like | BV97_02767-like | Family | 1,743 | false | false | This entry represents uncharacterised bacterial proteins. They are predicted to contain transmembrane helices. Members of this family are probably distantly related to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28289"
] | [
"BV97_02767"
] | [
1743
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR058117"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"ecological metagenomes"
] | [
1691,
9,
9,
34
] | 4 | [] | [] | 0 | true | Family | BV97_02767-like | BV97_02767-like | BV97_02767-like | 5 |
IPR060702 | 60,702 | HI_1480 | HI_1480 | Domain | 2 | false | false | This entry represents the HI1480 protein from Haemophilus influenzae an apparent ORF protein [ ]. The protein HI1480 from Haemophilus influenzae has been structurally characterised. It exhibits a unique amino acid sequence, lacking homology with known proteins. HI1480 adopts a novel α+β fold and forms dimers of tightly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22186"
] | [
"HI1480"
] | [
2
] | 1 | [] | [] | [] | 0 | [
"1mw5"
] | 1 | [
"PUB00028981"
] | [
"15229888"
] | [
"Novel structure and nucleotide binding properties of HI1480 from Haemophilus influenzae: a protein with no known sequence homologues."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Haemophilus"
] | [
2
] | 1 | [] | [] | 0 | true | Domain | HI_1480 | HI_1480 | HI_1480 | 6 |
IPR060703 | 60,703 | FcpA-like | FcpA-like | Family | 252 | false | false | This entry represents FcpA (flagellar-coiling protein A, , LEPBI_I0267) from Leptospira biflexa and similar sequences from Leptospiraceae lineage. It is part of the filament sheath of the spirochete periplasmic flagellum [ , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28277"
] | [
"FcpA"
] | [
252
] | 1 | [] | [] | [] | 0 | [
"6nqw",
"6nqx",
"6nqy",
"6pwb"
] | 4 | [
"PUB00159333",
"PUB00159334",
"PUB00159335",
"PUB00159395"
] | [
"27113476",
"29634754",
"28291747",
"29868490"
] | [
"A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete.",
"Leptospiral flagellar sheath protein FcpA interacts with FlaA2 and FlaB1 in Leptospira biflexa.",
"Crystallization of FcpA from Leptospira, a novel flagellar protein that ... | [
2016,
2018,
2017,
2018
] | 4 | [] | [
"IPR058091",
"IPR060705"
] | 0 | 2 | 0 | [
"Leptospiraceae",
"marine sediment metagenome"
] | [
251,
1
] | 2 | [] | [] | 0 | true | Family | FcpA-like | FcpA-like | FcpA-like | 1 |
IPR060704 | 60,704 | Uncharacterised conserved protein UCP029691-like | UCP029691-like | Family | 716 | false | false | This uncharacterised family of bacterial proteins has a membrane β barrel structure suggesting it may have a transport function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27733"
] | [
"UCP029691"
] | [
716
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR016934"
] | 0 | 1 | 0 | [
"Bacteria",
"bioreactor metagenome"
] | [
715,
1
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP029691-like | Uncharacterised conserved protein UCP029691-like | UCP029691-like | 6 |
IPR060705 | 60,705 | FcpA-related putative periplasmic flagellar protein | Lepto_FcpA-rel | Family | 120 | false | false | Members of this family are paralogous to FcpA, likewise a single copy protein when present, and not yet characterised. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF047449"
] | [
"Lepto_FcpA_rel"
] | [
120
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR060703"
] | [] | 1 | 0 | 1 | [
"Leptospira"
] | [
120
] | 1 | [] | [] | 0 | true | Family | FcpA-related putative periplasmic flagellar protein | FcpA-related putative periplasmic flagellar protein | Lepto_FcpA-rel | 4 |
IPR060706 | 60,706 | Uncharacterised conserved protein UCP030365-like | UCP030365-like | Family | 1,705 | false | false | This entry represents a group of uncharacterised proteins from plants. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF27747",
"PTHR33924"
] | [
"UCP030365",
""
] | [
1249,
1667
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR016953"
] | 0 | 1 | 0 | [
"Viridiplantae"
] | [
1705
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
24,
6,
27
] | 3 | true | Family | Uncharacterised conserved protein UCP030365-like | Uncharacterised conserved protein UCP030365-like | UCP030365-like | 4 |
IPR060710 | 60,710 | Tail spike protein-like, C-terminal | Tail_spike_C | Domain | 3 | false | false | This domain is found at the C-terminal end of Tail spike protein from Enterobacteria phage HK620 (9) . This domain adopts a β-barrel configuration [ ]. This domain is also found at the C-terminal of uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22424"
] | [
"HK620_9_C"
] | [
3
] | 1 | [] | [] | [] | 0 | [
"2vji",
"2vjj",
"2x6w",
"2x6x",
"2x6y",
"2x85",
"4avz",
"4xkv",
"4xkw",
"4xl9",
"4xla",
"4xlc",
"4xle",
"4xlf",
"4xlh",
"4xm3",
"4xmy",
"4xn0",
"4xn3",
"4xnf",
"4xon",
"4xop",
"4xor",
"4xot",
"4xqf",
"4xr6",
"4yej",
"4yel",
"6g0x",
"6gvp",
"6gvr"
] | 31 | [
"PUB00049762",
"PUB00154006",
"PUB00154007"
] | [
"18547389",
"22923442",
"30044908"
] | [
"Crystal structure of Escherichia coli phage HK620 tailspike: podoviral tailspike endoglycosidase modules are evolutionarily related.",
"Single amino acid exchange in bacteriophage HK620 tailspike protein results in thousand-fold increase of its oligosaccharide affinity.",
"Solvent Networks Tune Thermodynamics ... | [
2008,
2013,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Enterobacteria phage HK620",
"Enterobacteriaceae"
] | [
1,
2
] | 2 | [] | [] | 0 | true | Domain | Tail spike protein-like, C-terminal | Tail spike protein-like, C-terminal | Tail_spike_C | 9 |
IPR060715 | 60,715 | MAP_0585-like, C-terminal | MAP_0585_C | Domain | 166 | false | false | This entry represents the C-terminal region of a group of proteins from mycobacteria, including MAP_0585 from Mycolicibacterium paratuberculosis . The protein has been studied as a vaccine component but is otherwise uncharacterised [ , ]. The C-terminal region is enriched with proline and glycine residues. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28171"
] | [
"MAP_0585"
] | [
166
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153506",
"PUB00153507"
] | [
"35455267",
"31683552"
] | [
"Immunological Evaluation of Goats Immunized with a Commercial Vaccine against Johne's Disease.",
"Characterization of Ethanol Extracted Cell Wall Components of <i>Mycobacterium avium</i> Subsp. <i>paratuberculosis</i>."
] | [
2022,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Mycobacteriales"
] | [
166
] | 1 | [] | [] | 0 | true | Domain | MAP_0585-like, C-terminal | MAP_0585-like, C-terminal | MAP_0585_C | 6 |
IPR060716 | 60,716 | Anti-phage protein Upx related | Upx-rel | Family | 261 | false | false | Proteins members of this family exhibit anti-phage activities [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28173"
] | [
"Upx-like"
] | [
261
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152882"
] | [
"32855333"
] | [
"Diverse enzymatic activities mediate antiviral immunity in prokaryotes."
] | [
2020
] | 1 | [] | [
"IPR049965"
] | 0 | 1 | 0 | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
249,
5,
7
] | 3 | [] | [] | 0 | true | Family | Anti-phage protein Upx related | Anti-phage protein Upx related | Upx-rel | 2 |
IPR060717 | 60,717 | LIM-domain binding protein, DD and LCCD | LIM_bind_DD/LCCD | Domain | 9,770 | false | false | This entry represents the dimerization domain (DD) of LIM domain-binding protein 1 (LDB1) from human and related proteins, which consists of a NTF2-like subdomain and a small helix 4-helix 5 subdomain [ , ]. This entry also covers the LDB1/Chip conserved domain (LCCD) which is a short segment following the DD, which in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01803"
] | [
"LIM_bind"
] | [
9770
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-8939236",
"R-HSA-8939236",
"R-HSA-9010553",
"R-HSA-9733709",
"R-HSA-9752946",
"R-MMU-8939236"
] | [
"REACTOME:R-GGA-8939236",
"REACTOME:R-HSA-8939236",
"REACTOME:R-HSA-9010553",
"REACTOME:R-HSA-9733709",
"REACTOME:R-HSA-9752946",
"REACTOME:R-MMU-8939236"
] | 6 | [
"6ptl",
"6s9s",
"6s9t",
"6tyd",
"8hib",
"9bpo",
"9czs",
"9ozv"
] | 8 | [
"PUB00001928",
"PUB00001929",
"PUB00004246",
"PUB00004875",
"PUB00102084",
"PUB00162550",
"PUB00162551",
"PUB00162552"
] | [
"9192866",
"9334334",
"8918878",
"8876198",
"18539116",
"31892537",
"37349336",
"16815859"
] | [
"A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.",
"Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila.",
"Interactions of the LIM-domain-binding factor Ldb1 wit... | [
1997,
1997,
1996,
1996,
2008,
2020,
2023,
2006
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9770
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
17,
2,
50,
3,
10,
4,
1,
15,
8,
1,
1,
84
] | 12 | true | Domain | LIM-domain binding protein, DD and LCCD | LIM-domain binding protein, DD and LCCD | LIM_bind_DD/LCCD | 6 |
IPR060718 | 60,718 | LEA protein 1/2/D7/Stress-induced protein KIN1/2-like | LEA1_2_D7_KIN1/2-like | Family | 2,621 | false | false | This entry represents a group of proteins from plants, including the Late embryogenesis abundant proteins (LEAs), late embryonic proteins abundant in higher plant seed embryos LEA1/2 from Cicer arietinum (Chickpea) and LEAD7 from Gossypium hirsutum (Upland cotton) [ ]; and Stress-induced protein KIN1/2 from Arabidopsis... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27970"
] | [
"LEA1_2_D7_KIN2"
] | [
2621
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089886",
"PUB00153042",
"PUB00153043",
"PUB00153044"
] | [
"7647294",
"16258011",
"17965713",
"25988244"
] | [
"Promoters from kin1 and cor6.6, two homologous Arabidopsis thaliana genes: transcriptional regulation and gene expression induced by low temperature, ABA, osmoticum and dehydration.",
"The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in... | [
1995,
2005,
2007,
2015
] | 4 | [] | [
"IPR039624"
] | 0 | 1 | 0 | [
"Agrococcus pavilionensis RW1",
"Eukaryota"
] | [
1,
2620
] | 2 | [
"Arabidopsis thaliana"
] | [
35
] | 1 | true | Family | LEA protein 1/2/D7/Stress-induced protein KIN1/2-like | LEA protein 1/2/D7/Stress-induced protein KIN1/2-like | LEA1_2_D7_KIN1/2-like | 1 |
IPR060720 | 60,720 | Accessory protein NS6, delta/gammacoronavirus | NS6_delta/gamma_CoV | Family | 80 | false | false | This family includes the accessory protein NS6 from deltacoronavirus such as porcine coronavirus HKU15, and several avian coronaviruses found in sparrow, pigeon, quail and falcon, and from gammacoronaviruses such as duck coronavirus, Canada goose coronavirus among others. Porcine deltacoronavirus (PDCoV) encodes three ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27996"
] | [
"NS6_deltaCoV"
] | [
80
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095901"
] | [
"29769346"
] | [
"Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA."
] | [
2018
] | 1 | [] | [
"IPR044335"
] | 0 | 1 | 0 | [
"Coronaviridae"
] | [
80
] | 1 | [] | [] | 0 | true | Family | Accessory protein NS6, delta/gammacoronavirus | Accessory protein NS6, delta/gammacoronavirus | NS6_delta/gamma_CoV | 1 |
IPR060721 | 60,721 | Novel STAND NTPase 7 | nSTAND_NTPase7 | Domain | 29 | false | false | This entry represents a novel domain of the STAND-superfamily of AAA+ ATPases found in bacterial conflict systems, including Inactive Sirtuin domain-containing protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24404"
] | [
"nSTAND_NTPase7"
] | [
29
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155486"
] | [
"37889040"
] | [
"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Exaiptasia diaphana",
"mine drainage metagenome"
] | [
26,
1,
2
] | 3 | [] | [] | 0 | true | Domain | Novel STAND NTPase 7 | Novel STAND NTPase 7 | nSTAND_NTPase7 | 6 |
IPR060722 | 60,722 | Magnetosome protein MamG/MamD-like | MamG/MamD-like | Family | 55 | false | false | This entry represents the Magnetosome proteins MamG, MamD, Mms5 from Paramagnetospirillum magneticum and related proteins, including Magnetite biomineralization protein Mms6. This family of proteins is involved in the biomineralisation process, specifically in the formation and regulation of magnetite crystals within m... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28196"
] | [
"Magnetosome_regulatory"
] | [
55
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106120",
"PUB00163195"
] | [
"22716969",
"36654913"
] | [
"The magnetosome membrane protein, MmsF, is a major regulator of magnetite biomineralization in Magnetospirillum magneticum AMB-1.",
"Key gene networks that control magnetosome biomineralization in magnetotactic bacteria."
] | [
2012,
2023
] | 2 | [] | [
"IPR053512",
"IPR053517"
] | 0 | 2 | 0 | [
"Pseudomonadota",
"leotiomyceta"
] | [
52,
3
] | 2 | [] | [] | 0 | true | Family | Magnetosome protein MamG/MamD-like | Magnetosome protein MamG/MamD-like | MamG/MamD-like | 9 |
IPR060723 | 60,723 | Dispersin | Dispersin | Family | 30 | false | false | This entry represents Dispersin from enteroaggregative Escherichia coli and related proteins. Dispersin is secreted to the bacterial cell surface. Dispersin-null mutants display a unique hyper-aggregating phenotype, accompanied by collapse of AAF pili onto the bacterial cell surface [ ]. Dispersin binds non-covalently ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28204"
] | [
"CellEnv_BiogenAssoc"
] | [
30
] | 1 | [] | [] | [] | 0 | [
"2jvu"
] | 1 | [
"PUB00048108"
] | [
"17986189"
] | [
"Solution structure of the novel dispersin protein of enteroaggregative Escherichia coli."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
30
] | 1 | [] | [] | 0 | true | Family | Dispersin | Dispersin | Dispersin | 4 |
IPR060724 | 60,724 | Protein DVU_0533 | DVU_0533 | Family | 100 | false | false | This entry represents the Protein DVU_0533 (also known as HMC operon ORF 4) from Nitratidesulfovibrio vulgaris and related proteins. HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenas... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28260"
] | [
"sulf_resp_HmcD"
] | [
100
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154757"
] | [
"8335628"
] | [
"The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough encodes a potential transmembrane redox protein complex."
] | [
1993
] | 1 | [] | [
"IPR054911"
] | 0 | 1 | 0 | [
"Bacteria",
"Candidatus Methanoperedens nitratireducens",
"bioreactor metagenome"
] | [
97,
2,
1
] | 3 | [] | [] | 0 | true | Family | Protein DVU_0533 | Protein DVU_0533 | DVU_0533 | 8 |
IPR060725 | 60,725 | General secretion pathway protein N-like | XpsN | Family | 552 | false | false | This entry represents a group of proteins mainly from Lysobacteraceae, Pseudomonadaceae and Rhodanobacteraceae, including General secretion pathway protein N from Xanthomonas campestris (XspN, , which is implicated in the general secretion pathway (GSP) for the efficient export of proteins [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF28060"
] | [
"XpsN"
] | [
552
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094012",
"PUB00151444"
] | [
"10692359",
"15590656"
] | [
"Association of the cytoplasmic membrane protein XpsN with the outer membrane protein XpsD in the type II protein secretion apparatus of Xanthomonas campestris pv. campestris.",
"Associations of the major pseudopilin XpsG with XpsN (GspC) and secretin XpsD of Xanthomonas campestris pv. campestris type II secretio... | [
2000,
2005
] | 2 | [] | [
"IPR048187"
] | 0 | 1 | 0 | [
"Knufia peltigerae",
"Pseudomonadati",
"hydrothermal vent metagenome"
] | [
1,
550,
1
] | 3 | [] | [] | 0 | true | Family | General secretion pathway protein N-like | General secretion pathway protein N-like | XpsN | 7 |
IPR060726 | 60,726 | Transmembrane cell adhesion receptor mua-3-like, EGF-like domain | EGF_Mua-3 | Domain | 321 | false | false | This EGF-like domain is found in Transmembrane cell adhesion receptor mua-3 from Caenorhabditis elegans, which is involved in cell adhesion and required for organ positioning and attachment [ ]. This entry includes Transmembrane matrix receptor MUP-4. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25478"
] | [
"EGF_Mua-3"
] | [
321
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159014",
"PUB00160132"
] | [
"11470828",
"32198364"
] | [
"mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes.",
"NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance."
] | [
2001,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
321
] | 1 | [
"Caenorhabditis elegans"
] | [
2
] | 1 | true | Domain | Transmembrane cell adhesion receptor mua-3-like, EGF-like domain | Transmembrane cell adhesion receptor mua-3-like, EGF-like domain | EGF_Mua-3 | 8 |
IPR060734 | 60,734 | GbsR-like, C-terminal helical hairpin | GbsR-like_C | Domain | 1,623 | false | false | This entry represents the C-terminal α-helical hairpin domain found in GbsR family transcriptional regulators from Bacillus subtilis and related Bacilli bacteria. This domain is distinct from the N-terminal helix-turn-helix (HTH) DNA-binding domain . The C-terminal domain may be involved in ligand sensing, protein olig... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27113"
] | [
"GbsR_C"
] | [
1623
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161973",
"PUB00161974"
] | [
"22408163",
"23960087"
] | [
"Genetic control of osmoadaptive glycine betaine synthesis in Bacillus subtilis through the choline-sensing and glycine betaine-responsive GbsR repressor.",
"Involvement of OpcR, a GbsR-type transcriptional regulator, in negative regulation of two evolutionarily closely related choline uptake genes in Bacillus su... | [
2012,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"human gut metagenome"
] | [
1620,
2,
1
] | 3 | [] | [] | 0 | true | Domain | GbsR-like, C-terminal helical hairpin | GbsR-like, C-terminal helical hairpin | GbsR-like_C | 1 |
IPR060735 | 60,735 | YjaZ | YjaZ | Family | 721 | false | false | This entry represents YjaZ, a 179 amino acid protein from Escherichia coli (gene b3989). YjaZ expression increases about 5-fold as cells approach stationary phase under control of sigma factor S (rpoS) [ ]. Disruption mutants grow normally at various temperatures but have slightly slower growth as they enter stationary... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27200"
] | [
"YjaZ"
] | [
721
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162418",
"PUB00162419"
] | [
"16980444",
"2160943"
] | [
"The Escherichia coli rpoS-dependent htrC gene is not involved in the heat shock response.",
"A new Escherichia coli heat shock gene, htrC, whose product is essential for viability only at high temperatures."
] | [
2006,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Pancrustacea",
"unclassified sequences"
] | [
709,
2,
10
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YjaZ | YjaZ | YjaZ | 9 |
IPR060736 | 60,736 | Uridylyltransferase GlnD, third domain | GlnD_3rd | Domain | 9,831 | false | false | This entry represents the third domain of bifunctional uridylyltransferase/uridylyl-removing enzyme GlnD. GlnD is a uridylyltransferase/uridylyl-removing enzyme for signal-transduction protein PII which acts as the sensory component of the nitrogen regulation (ntr) system [ , ]. The ntr system modulates nitrogen metabo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27444"
] | [
"GlnD_3rd"
] | [
9831
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.59",
"3.1.4.-",
"PWY-5978",
"PWY-6129",
"PWY-6689",
"PWY-7119",
"PWY-7366"
] | [
"EC:2.7.7.59",
"EC:3.1.4.-",
"METACYC:PWY-5978",
"METACYC:PWY-6129",
"METACYC:PWY-6689",
"METACYC:PWY-7119",
"METACYC:PWY-7366"
] | 7 | [] | 0 | [
"PUB00006542",
"PUB00015136",
"PUB00015137"
] | [
"6130097",
"11065377",
"11810255"
] | [
"Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme.",
"The Rhizobium leguminosarum bv. viciae glnD gene, encoding a uridylyltransferase/uridylyl-removing enzyme, is expressed in the root nodule but is not essential for nit... | [
1983,
2000,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
9700,
13,
118
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Uridylyltransferase GlnD, third domain | Uridylyltransferase GlnD, third domain | GlnD_3rd | 9 |
IPR060737 | 60,737 | Uridylyltransferase GlnD, helical domain | GlnD_helical | Domain | 6,872 | false | false | This entry represents a helical domain of bifunctional uridylyltransferase/uridylyl-removing enzyme GlnD. GlnD is a uridylyltransferase/uridylyl-removing enzyme for signal-transduction protein PII which acts as the sensory component of the nitrogen regulation (ntr) system [ , ]. The ntr system modulates nitrogen metabo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27446"
] | [
"GlnD_5th"
] | [
6872
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.59",
"3.1.4.-",
"PWY-5978",
"PWY-6129",
"PWY-6689",
"PWY-7119",
"PWY-7366"
] | [
"EC:2.7.7.59",
"EC:3.1.4.-",
"METACYC:PWY-5978",
"METACYC:PWY-6129",
"METACYC:PWY-6689",
"METACYC:PWY-7119",
"METACYC:PWY-7366"
] | 7 | [] | 0 | [
"PUB00006542",
"PUB00015136",
"PUB00015137"
] | [
"6130097",
"11065377",
"11810255"
] | [
"Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme.",
"The Rhizobium leguminosarum bv. viciae glnD gene, encoding a uridylyltransferase/uridylyl-removing enzyme, is expressed in the root nodule but is not essential for nit... | [
1983,
2000,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6791,
8,
73
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Uridylyltransferase GlnD, helical domain | Uridylyltransferase GlnD, helical domain | GlnD_helical | 3 |
IPR060740 | 60,740 | TOF1-like, helical domain | TOF-1-like_helical | Domain | 4,748 | false | false | This entry represents a helical domain in Topoisomerase 1-associated factor 1 (TOF1), Protein timeless homolog, Mating-type switching protein swi1 (swi1), and Uncharacterized protein PF3D7_0210200. TOF1 forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and D... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27570"
] | [
"PF3D7_5th"
] | [
4748
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-432395",
"R-DME-432490",
"R-DME-432501",
"R-DME-432553",
"R-DME-432620",
"R-DME-538898",
"R-HSA-5693607",
"R-MMU-5693607",
"R-RNO-5693607"
] | [
"REACTOME:R-DME-432395",
"REACTOME:R-DME-432490",
"REACTOME:R-DME-432501",
"REACTOME:R-DME-432553",
"REACTOME:R-DME-432620",
"REACTOME:R-DME-538898",
"REACTOME:R-HSA-5693607",
"REACTOME:R-MMU-5693607",
"REACTOME:R-RNO-5693607"
] | 9 | [
"6skl",
"6xwx",
"7pfo",
"7plo",
"7pmk",
"7pmn",
"8b9a",
"8b9b",
"8b9c",
"8b9d",
"8dd7",
"8kg6",
"8ouw",
"8xgc",
"9e2w",
"9e2x"
] | 16 | [
"PUB00162224",
"PUB00162225",
"PUB00162554"
] | [
"17653272",
"9804551",
"28855376"
] | [
"Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif.",
"Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.",
"Destabilization of the replication fork protection complex disrupts meiotic chromosome segregation."
] | [
2007,
1998,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4748
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
7,
2,
2,
1,
3,
4,
1,
1,
10
] | 12 | true | Domain | TOF1-like, helical domain | TOF1-like, helical domain | TOF-1-like_helical | 3 |
IPR060742 | 60,742 | MAP3K7-like, C-terminal coiled coil | MAPK37_C | Domain | 3,229 | false | false | This entry represents the C-terminal coiled coil region in Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) and MAP3K7 C-terminal-like protein. The proteins are found in vertebrates and show ubiquitous tissue expression. MAP3K7 C-terminal-like proteins are small proteins of approximately 142 amino acids. The r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27575"
] | [
"Map3k7cl"
] | [
3229
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.25",
"R-BTA-168638",
"R-BTA-202424",
"R-BTA-2871837",
"R-BTA-4086398",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5357956",
"R-BTA-5607764",
"R-BTA-5689880",
"R-BTA-9020702",
"R-BTA-937042",
"R-BTA-937072",
"R-BTA-9645460",
"R-BTA-975163",
"R-DME-209447",
"R-DME-4086398",
"R-DM... | [
"EC:2.7.11.25",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-4086398",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-5357956",
"REACTOME:R-BTA-5607764",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-9020702",
"REACTOME:R-BTA-937042... | 67 | [] | 0 | [
"PUB00016455",
"PUB00095285"
] | [
"11707072",
"12589052"
] | [
"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.",
"Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kina... | [
2001,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3229
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
6,
13,
6,
9
] | 5 | true | Domain | MAP3K7-like, C-terminal coiled coil | MAP3K7-like, C-terminal coiled coil | MAPK37_C | 8 |
IPR060743 | 60,743 | Spore coat protein Yuth-like | YutH-like | Family | 2,700 | false | false | This entry represents YutH, Spore coat protein S and Sporte coat protein I. YutH, is found only in the family Bacillaceae, part of the endospore-forming group within the Firmicutes. YutH has been shown to be involved in spore coat assmebly [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27663"
] | [
"Spore_coat_YutH"
] | [
2700
] | 1 | [] | [] | [] | 0 | [
"2q83"
] | 1 | [
"PUB00016405"
] | [
"15231775"
] | [
"Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis."
] | [
2004
] | 1 | [
"IPR047175"
] | [
"IPR014254"
] | 1 | 1 | 0 | [
"Bacteria",
"metagenomes"
] | [
2687,
13
] | 2 | [] | [] | 0 | true | Family | Spore coat protein Yuth-like | Spore coat protein Yuth-like | YutH-like | 7 |
IPR060744 | 60,744 | Uncharacterized membrane protein YGR016W | YGR016W | Family | 501 | false | false | This entry represents uncharacterised YGR016W protein from S.cerevisae. This entry includes related uncharacterised proteins in fungi and plants. YGR016W contains an all helical fold. It is present with 238 molecules/cell in log phase SD medium [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27705"
] | [
"UCP010056"
] | [
501
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042821"
] | [
"14562106"
] | [
"Global analysis of protein expression in yeast."
] | [
2003
] | 1 | [] | [
"IPR016564"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
501
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
1,
9
] | 2 | true | Family | Uncharacterized membrane protein YGR016W | Uncharacterized membrane protein YGR016W | YGR016W | 7 |
IPR060746 | 60,746 | Increased recombination centres protein 19 | Irc19 | Family | 126 | false | false | This entry represents Irc19 in Saccharomycetes and Pichiomycetes. Irc19 is involved in sporulation and maintenance of the mitochondrial DNA [ , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27708"
] | [
"Irc19"
] | [
126
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071556",
"PUB00074953",
"PUB00074954"
] | [
"19751518",
"12432101",
"11921089"
] | [
"Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae.",
"Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae.",
"Systematic analysis of ... | [
2009,
2002,
2002
] | 3 | [] | [
"IPR016613"
] | 0 | 1 | 0 | [
"Saccharomycotina"
] | [
126
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Increased recombination centres protein 19 | Increased recombination centres protein 19 | Irc19 | 2 |
IPR060747 | 60,747 | TraD, N-terminal | TraD_b_g-type_N | Domain | 391 | false | false | This entry represents TraD found in IncP conjugative plasmids [ ], from gamma and betaproteobacteria. The function has not been elucidated. This domain can be found covering the full length or the N-terminal region. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF27712"
] | [
"TraD_b_g-type"
] | [
391
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094508"
] | [
"1818755"
] | [
"Gene organization and nucleotide sequence of the primase region of IncP plasmids RP4 and R751."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Tanacetum cinerariifolium",
"hydrothermal vent metagenome",
"plasmids"
] | [
382,
1,
1,
7
] | 4 | [] | [] | 0 | true | Domain | TraD, N-terminal | TraD, N-terminal | TraD_b_g-type_N | 1 |
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