prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)NC2=[NH+]CCCCC2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C1=[NH+]CCCCC1",
"old_substring": "N3C1=[NH+]CCC1"
}
|
Can you make molecule Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)NC2=NCCCS2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1
|
Cc1ccc([C@@H](C)NC2=NCCCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C1=NCCCS1",
"old_substring": "N3C1=[NH+]CCC1"
}
|
Can you make molecule Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)NC2=NCCCO2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1
|
Cc1ccc([C@@H](C)NC2=NCCCO2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C1=NCCCO1",
"old_substring": "N3C1=[NH+]CCC1"
}
|
Can you make molecule Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)NC2=NO[C@H](C)C2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1
|
Cc1ccc([C@@H](C)NC2=NO[C@H](C)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C1=NO[C@H](C)C1",
"old_substring": "N3C1=[NH+]CCC1"
}
|
Can you make molecule Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)NC2=NCCS2)cc1
|
Cc1ccc([C@@H](C)NC2=[NH+]CCC2)cc1
|
Cc1ccc([C@@H](C)NC2=NCCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C1=NCCS1",
"old_substring": "N3C1=[NH+]CCC1"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2ccncc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCNSC(=O)Cc2ccncc2)cc1
|
COc1ccc(CCNC(=O)c2ccncc2)cc1
|
COc1ccc(CCNSC(=O)Cc2ccncc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2ccncc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCNC(=O)CCCC(=O)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)CCCC(=O)c2ccncc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2ccncc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCNC(=O)CC(C)(C)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)CC(C)(C)c2ccncc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2ccncc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCNC(=O)CCC(C)(C)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)CCC(C)(C)c2ccncc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule COc1ccc(CCNC(=O)c2ccncc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCNSC(=O)[C@@H](C)c2ccncc2)cc1
|
COc1ccc(CCNC(=O)c2ccncc2)cc1
|
COc1ccc(CCNSC(=O)[C@@H](C)c2ccncc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC(O)(C3CC3)CC2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCC(O)(C3CC3)CC2)cc(Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&(O)CC1",
"old_substring": "[NH+]17CCN9C(=O)C1"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCN(CC3CC3)CC2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(CC3CC3)CC2)cc(Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCN(C&)CC1",
"old_substring": "[NH+]17CCN9C(=O)C1"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CC=C(CC3CC3)CC2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CC=C(CC3CC3)CC2)cc(Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(C&)CC1",
"old_substring": "[NH+]17CCN9C(=O)C1"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCCN(CC3CC3)CC2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCCN(CC3CC3)CC2)cc(Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCN(C&)CC1",
"old_substring": "[NH+]17CCN9C(=O)C1"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC(C3CC3)CC2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
|
CCOc1cc(C[NH+]2CCC(C3CC3)CC2)cc(Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "[NH+]17CCN9C(=O)C1"
}
|
Can you make molecule Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Nc2ncnc(N(CC#N)CCCC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)CCCC#N)c2N)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC#N",
"old_substring": "C3C#N"
}
|
Can you make molecule Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Nc2ncnc(N(CC#N)C3(C#N)CC3)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)C3(C#N)CC3)c2N)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CC1",
"old_substring": "C3C#N"
}
|
Can you make molecule Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C#N)(CC)N(CC#N)c1ncnc(Nc2nc(C)c(C)s2)c1N
|
Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C
|
CCC(C#N)(CC)N(CC#N)c1ncnc(Nc2nc(C)c(C)s2)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C#N)CC",
"old_substring": "C3C#N"
}
|
Can you make molecule Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Nc2ncnc(N(CC#N)C3(C#N)CCC3)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)C3(C#N)CCC3)c2N)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC1",
"old_substring": "C3C#N"
}
|
Can you make molecule Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Nc2ncnc(N(CC#N)SC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)CC#N)c2N)sc1C
|
Cc1nc(Nc2ncnc(N(CC#N)SC#N)c2N)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C#N",
"old_substring": "C3C#N"
}
|
Can you make molecule COc1cccc(Nc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cccc(Nc2ccccc2)c1
|
COc1cccc(Nc2ccccc2)c1
|
COCc1cccc(Nc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc(Nc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cccc(Nc2ccccc2)c1
|
COc1cccc(Nc2ccccc2)c1
|
COCSc1cccc(Nc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc(Nc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1cccc(Nc2ccccc2)c1
|
COc1cccc(Nc2ccccc2)c1
|
CC(=O)Sc1cccc(Nc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc(Nc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1cccc(Nc2ccccc2)c1
|
COc1cccc(Nc2ccccc2)c1
|
O=C(CS)c1cccc(Nc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1cccc(Nc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1cccc(Nc2ccccc2)c1
|
COc1cccc(Nc2ccccc2)c1
|
O=C(CI)c1cccc(Nc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(SC(=O)Cc2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(SC(=O)Cc2nnc3sc(-c4ccccc4Cl)nn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C(=O)CCCC(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)CCCC(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C(=O)CC(C)(C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)CC(C)(C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(C(=O)CCC(C)(C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)CCC(C)(C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN(SC(=O)[C@@H](C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(C(=O)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
|
CCN1CCN(SC(=O)[C@@H](C)c2nnc3sc(-c4ccccc4Cl)nn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C57=O"
}
|
Can you make molecule O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(SN1CCN(Cc2cccc3ccccc23)CC1)C1CCN(S(=O)(=O)c2cccs2)CC1
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
|
O=C(SN1CCN(Cc2cccc3ccccc23)CC1)C1CCN(S(=O)(=O)c2cccs2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&N1CCN&CC1",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN=C1CCc1cccc2ccccc12
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN=C1CCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1C&",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCCN(Cc2cccc3ccccc23)C1=O
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCCN(Cc2cccc3ccccc23)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCN&C1=O",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN=C1SCc1cccc2ccccc12
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN=C1SCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN(C(=O)C2CCN(S(=O)(=O)c3cccs3)CC2)CCN1Cc1cccc2ccccc12
|
O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1
|
CC1(C)CN(C(=O)C2CCN(S(=O)(=O)c3cccs3)CC2)CCN1Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN&C(C)(C)C1",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2Cl)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2Cl)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccc(I)cc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccc(I)cc2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccc(C)c(I)c2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccc(C)c(I)c2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2cccc(Br)c2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2cccc(Br)c2)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2cccc(C)c2C)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2ccccc2)no1
|
Cc1cc(NC(=O)CCS(=O)(=O)[C@H](C)c2cccc(C)c2C)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c15ccccc1"
}
|
Can you make molecule Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)sc1C
|
Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1cc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&sc1C",
"old_substring": "Cc1cnc7s1"
}
|
Can you make molecule Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)c([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1cc(Br)c([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Br)c&s1",
"old_substring": "Cc1cnc7s1"
}
|
Can you make molecule Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2sc([C@@H](C)NC(=O)NCC(C)(C)c3ccccc3Cl)nc2c1
|
Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1ccc2sc([C@@H](C)NC(=O)NCC(C)(C)c3ccccc3Cl)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&nc2c1",
"old_substring": "Cc1cnc7s1"
}
|
Can you make molecule Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc([C@@H](C)NC(=O)NCC(C)(C)c3ccccc3Cl)sc2c1
|
Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1ccc2nc([C@@H](C)NC(=O)NCC(C)(C)c3ccccc3Cl)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2nc&sc2c1",
"old_substring": "Cc1cnc7s1"
}
|
Can you make molecule Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)c1Cl
|
Cc1cnc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)s1
|
Cc1csc([C@@H](C)NC(=O)NCC(C)(C)c2ccccc2Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1csc&c1Cl",
"old_substring": "Cc1cnc7s1"
}
|
Can you make molecule CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
C=CSn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
}
|
Can you make molecule CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)n1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
CC(C)n1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC5"
}
|
Can you make molecule CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
C=CCCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
}
|
Can you make molecule CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1cc(F)c2c(c1)C[NH+](Cc1cnn(CCCCl)c1)CC2
|
CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
Fc1cc(F)c2c(c1)C[NH+](Cc1cnn(CCCCl)c1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC5"
}
|
Can you make molecule CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1cc(F)c2c(c1)C[NH+](Cc1cnn(CCCCS)c1)CC2
|
CCn1cc(C[NH+]2CCc3c(F)cc(F)cc3C2)cn1
|
Fc1cc(F)c2c(c1)C[NH+](Cc1cnn(CCCCS)c1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC5"
}
|
Can you make molecule C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1I
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1I",
"old_substring": "C=6c1ccccc1"
}
|
Can you make molecule C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1Br
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1Br",
"old_substring": "C=6c1ccccc1"
}
|
Can you make molecule C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1Cl
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1Cl",
"old_substring": "C=6c1ccccc1"
}
|
Can you make molecule C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=CCn1c([C@H](C)NC(=O)C2CC2)nc2ccccc21)c1ccccc1F
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1
|
CC(=CCn1c([C@H](C)NC(=O)C2CC2)nc2ccccc21)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1ccccc1F",
"old_substring": "C=6c1ccccc1"
}
|
Can you make molecule C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=CCn1c([C@H](C)NC(=O)C2CC2)nc2ccccc21)c1ccccc1
|
C[C@H](NC(=O)C1CC1)c1nc2ccccc2n1CC=Cc1ccccc1
|
CCC(=CCn1c([C@H](C)NC(=O)C2CC2)nc2ccccc21)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&c1ccccc1",
"old_substring": "C=6c1ccccc1"
}
|
Can you make molecule CN1CC[C@H](SCc2ccc(F)cc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CC[C@H](SCSCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](SCSCc2ccc(F)cc2F)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S35"
}
|
Can you make molecule CN1CC[C@H](SCc2ccc(F)cc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CC[C@H](CC/N=C2\SCCCN2Cc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](CC/N=C2\SCCCN2Cc2ccc(F)cc2F)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCS/C1=N\\CC&",
"old_substring": "S35"
}
|
Can you make molecule CN1CC[C@H](SCc2ccc(F)cc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CC[C@H](c2ccc3c(c2)N(Cc2ccc(F)cc2F)CCS3)C1=O
|
CN1CC[C@H](SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](c2ccc3c(c2)N(Cc2ccc(F)cc2F)CCS3)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S35"
}
|
Can you make molecule CN1CC[C@H](SCc2ccc(F)cc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CC[C@H](N/C(C#N)=C(\Cl)SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](N/C(C#N)=C(\Cl)SCc2ccc(F)cc2F)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S35"
}
|
Can you make molecule CN1CC[C@H](SCc2ccc(F)cc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CC[C@H](n2c(=S)n(Cc3ccc(F)cc3F)c3ccccc32)C1=O
|
CN1CC[C@H](SCc2ccc(F)cc2F)C1=O
|
CN1CC[C@H](n2c(=S)n(Cc3ccc(F)cc3F)c3ccccc32)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S35"
}
|
Can you make molecule Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)c(-c2snc(C(=O)C(=O)NC3CCC(O)CC3)c2N)cc1Cl
|
Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(-c2snc(C(=O)C(=O)NC3CCC(O)CC3)c2N)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N35"
}
|
Can you make molecule Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)c(SC(=S)N(C)C(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(SC(=S)N(C)C(=O)C(=O)NC2CCC(O)CC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)c(-c2cc(C(=O)C(=O)NC3CCC(O)CC3)oc2N)cc1Cl
|
Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(-c2cc(C(=O)C(=O)NC3CCC(O)CC3)oc2N)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N35"
}
|
Can you make molecule Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)c(SC2=NCCN2C(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(SC2=NCCN2C(=O)C(=O)NC2CCC(O)CC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)c(C2CCN(CC(=O)C(=O)NC3CCC(O)CC3)CC2)cc1Cl
|
Cc1cc(Cl)c(NC(=O)C(=O)NC2CCC(O)CC2)cc1Cl
|
Cc1cc(Cl)c(C2CCN(CC(=O)C(=O)NC3CCC(O)CC3)CC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N35"
}
|
Can you make molecule C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCc1cn(C(C)C)nc1SCC(=O)Nc1nc2ccccc2s1
|
C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C
|
C=CCc1cn(C(C)C)nc1SCC(=O)Nc1nc2ccccc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cn&nc1&",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCc1cc(C(C)C)nc2c(SCC(=O)Nc3nc4ccccc4s3)ncn12
|
C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C
|
C=CCc1cc(C(C)C)nc2c(SCC(=O)Nc3nc4ccccc4s3)ncn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2c&ncn12",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1cc(C(C)C)c2c(SCC(=O)Nc3nc4ccccc4s3)ncnc21
|
C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C
|
C=CCn1cc(C(C)C)c2c(SCC(=O)Nc3nc4ccccc4s3)ncnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&c2c&ncnc21",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1ccc2nc(C(C)C)nc(SCC(=O)Nc3nc4ccccc4s3)c21
|
C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C
|
C=CCn1ccc2nc(C(C)C)nc(SCC(=O)Nc3nc4ccccc4s3)c21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc2nc&nc&c21",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1cnc2c(C(C)C)cn(SCC(=O)Nc3nc4ccccc4s3)c2c1=O
|
C=CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1C(C)C
|
C=CCn1cnc2c(C(C)C)cn(SCC(=O)Nc3nc4ccccc4s3)c2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cnc2c&cn&c2c1=O",
"old_substring": "n17c8nnc19"
}
|
Can you make molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN(CCC(CO)=C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(CCC(CO)=C2CC[NH+](Cc3ccoc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN(SC(=O)CC2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(SC(=O)CC2CC[NH+](Cc3ccoc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN(CC(=C=O)CC2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(CC(=C=O)CC2CC[NH+](Cc3ccoc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN(C(=O)CCCC(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)CCCC(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN(C(=O)CC(C)(C)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)C2CC[NH+](Cc3ccoc3)CC2)C1
|
C[C@@H]1CCCN(C(=O)CC(C)(C)C2CC[NH+](Cc3ccoc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCC
|
CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "C=%10C1CC1"
}
|
Can you make molecule CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C1CC1.C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C
|
CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1
|
C=C1CC1.C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1CC1",
"old_substring": "C=%10C1CC1"
}
|
Can you make molecule CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.CC=C1CC1
|
CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.CC=C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&C1CC1",
"old_substring": "C=%10C1CC1"
}
|
Can you make molecule CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCCC
|
CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCCC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "C=%10C1CC1"
}
|
Can you make molecule CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCCl
|
CNC(=O)c1cc(Oc2cccc(OC(=O)C=CC3CC3)c2C)ccn1
|
C=CC(=O)Oc1cccc(Oc2ccnc(C(=O)NC)c2)c1C.C=CCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCCl",
"old_substring": "C=%10C1CC1"
}
|
Can you make molecule COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C#N)ccc1OCC(=O)Nc1c(F)cc(C(F)(F)F)cc1Cl
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1c(F)cc(C(F)(F)F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(F)cc&cc1Cl",
"old_substring": "c16cc7ccc1C"
}
|
Can you make molecule COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)c(F)cc1Cl
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)c(F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c(F)cc1Cl",
"old_substring": "c16cc7ccc1C"
}
|
Can you make molecule COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(Br)c(C(F)(F)F)cc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(Br)c(C(F)(F)F)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1C",
"old_substring": "c16cc7ccc1C"
}
|
Can you make molecule COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1Br
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16cc7ccc1C"
}
|
Can you make molecule COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C#N)ccc1OCC(=O)Nc1cccc(C(F)(F)F)c1Br
|
COc1cc(C#N)ccc1OCC(=O)Nc1cc(C(F)(F)F)ccc1C
|
COc1cc(C#N)ccc1OCC(=O)Nc1cccc(C(F)(F)F)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16cc7ccc1C"
}
|
Can you make molecule C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CO)CSCC(=O)N[C@H](C)CC(C)(C)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@H](C)CC(C)(C)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]36"
}
|
Can you make molecule C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CO)CSCC(=O)NCC[C@@H](C)CC(=O)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)NCC[C@@H](C)CC(=O)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]36"
}
|
Can you make molecule C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CO)CSCC(=O)N[C@@H](C)[C@H](C)Cc1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@@H](C)[C@H](C)Cc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]36"
}
|
Can you make molecule C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CO)CSCC(=O)NCC[C@H](C)CC(=O)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1
|
C[C@H](CO)CSCC(=O)NCC[C@H](C)CC(=O)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]36"
}
|
Can you make molecule C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1ccc(F)cc1)NC(=O)CSC[C@H](C)CO
|
C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1
|
CCC[C@@H](CCc1ccc(F)cc1)NC(=O)CSC[C@H](C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C[C@H]36"
}
|
Can you make molecule c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccccc1C[C@@H]1C[NH2+]CCC12Cc1ccccc1C2
|
c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
Clc1ccccc1C[C@@H]1C[NH2+]CCC12Cc1ccccc1C2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c1ccc5cc1"
}
|
Can you make molecule c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Ic1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
Ic1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c1ccc5cc1"
}
|
Can you make molecule c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1I
|
c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
Cc1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c1ccc5cc1"
}
|
Can you make molecule c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Brc1cccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)c1
|
c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
Brc1cccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c1ccc5cc1"
}
|
Can you make molecule c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)c1C
|
c1ccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)cc1
|
Cc1cccc(C[C@@H]2C[NH2+]CCC23Cc2ccccc2C3)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c1ccc5cc1"
}
|
Can you make molecule O=C1CNC(=O)N1CCSCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CNC(=O)N1CCN1CCSc2ccc(Cc3ccco3)cc21
|
O=C1CNC(=O)N1CCSCc1ccco1
|
O=C1CNC(=O)N1CCN1CCSc2ccc(Cc3ccco3)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S23"
}
|
Can you make molecule O=C1CNC(=O)N1CCSCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CNC(=O)N1CCSCSCc1ccco1
|
O=C1CNC(=O)N1CCSCc1ccco1
|
O=C1CNC(=O)N1CCSCSCc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S23"
}
|
Can you make molecule O=C1CNC(=O)N1CCSCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CNC(=O)N1CCc1cc(Cc2ccco2)n2c1CSC2
|
O=C1CNC(=O)N1CCSCc1ccco1
|
O=C1CNC(=O)N1CCc1cc(Cc2ccco2)n2c1CSC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&n2c1CSC2",
"old_substring": "S23"
}
|
Can you make molecule O=C1CNC(=O)N1CCSCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CNC(=O)N1CCc1nc2sc(Cc3ccco3)cc2s1
|
O=C1CNC(=O)N1CCSCc1ccco1
|
O=C1CNC(=O)N1CCc1nc2sc(Cc3ccco3)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2sc&cc2s1",
"old_substring": "S23"
}
|
Can you make molecule O=C1CNC(=O)N1CCSCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CNC(=O)N1CCc1cc2cn(Cc3ccco3)cc2s1
|
O=C1CNC(=O)N1CCSCc1ccco1
|
O=C1CNC(=O)N1CCc1cc2cn(Cc3ccco3)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cn&cc2s1",
"old_substring": "S23"
}
|
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