prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCCS3)s2)C(C)C)cc1C
|
CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCCS3)s2)C(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCS1",
"old_substring": "CS6"
}
|
Can you make molecule CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCCCS3)s2)C(C)C)cc1C
|
CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCCCS3)s2)C(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "CS6"
}
|
Can you make molecule CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3(C)SCCS3)s2)C(C)C)cc1C
|
CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3(C)SCCS3)s2)C(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1&SCCS1",
"old_substring": "CS6"
}
|
Can you make molecule CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCSCS3)s2)C(C)C)cc1C
|
CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3SCSCS3)s2)C(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "CS6"
}
|
Can you make molecule CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3CSCCSC3)s2)C(C)C)cc1C
|
CSc1nnc(S[C@H](C(=O)Nc2ccc(C)c(C)c2)C(C)C)s1
|
Cc1ccc(NC(=O)[C@@H](Sc2nnc(C3CSCCSC3)s2)C(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "CS6"
}
|
Can you make molecule CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
C=CSN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
C=CCCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCCCl)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CN(CCCCl)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCCCS)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CN(CCCCS)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCCBr)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CCN(C)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
|
CN(CCCBr)S(=O)(=O)NCc1ccc(-n2cccn2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS[C@H]1CC[C@@H](NC(=O)N2CCN=C2CCCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N2CCN=C2CCCN(C)C2CC[NH+](C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1C&",
"old_substring": "N45C"
}
|
Can you make molecule CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS[C@H]1CC[C@@H](NC(=O)c2cc(C#N)c(CCN(C)C3CC[NH+](C)CC3)s2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)c2cc(C#N)c(CCN(C)C3CC[NH+](C)CC3)s2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N45C"
}
|
Can you make molecule CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS[C@H]1CC[C@@H](NC(=O)c2ccc(CCN(C)C3CC[NH+](C)CC3)c(C#N)c2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)c2ccc(CCN(C)C3CC[NH+](C)CC3)c(C#N)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N45C"
}
|
Can you make molecule CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS[C@H]1CC[C@@H](NC(=O)ON=C2CCN(CCN(C)C3CC[NH+](C)CC3)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)ON=C2CCN(CCN(C)C3CC[NH+](C)CC3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N45C"
}
|
Can you make molecule CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS[C@H]1CC[C@@H](NC(=O)N2CCC=C(CCCN(C)C3CC[NH+](C)CC3)C2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N(C)CCN(C)C2CC[NH+](C)CC2)C1
|
CCS[C@H]1CC[C@@H](NC(=O)N2CCC=C(CCCN(C)C3CC[NH+](C)CC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N45C"
}
|
Can you make molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)c1Cl
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1csc&c1Cl",
"old_substring": "Cc1csc6n1"
}
|
Can you make molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)ncc1Br
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)ncc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&ncc1Br",
"old_substring": "Cc1csc6n1"
}
|
Can you make molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)cnc1Cl
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cnc1Cl",
"old_substring": "Cc1csc6n1"
}
|
Can you make molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)sc1C
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
|
Cc1cc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&sc1C",
"old_substring": "Cc1csc6n1"
}
|
Can you make molecule Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2sc([C@@H](NC(=O)N3CCOC[C@H]3C3CC3)C3CC3)nc12
|
Cc1csc([C@@H](NC(=O)N2CCOC[C@H]2C2CC2)C2CC2)n1
|
Cc1cccc2sc([C@@H](NC(=O)N3CCOC[C@H]3C3CC3)C3CC3)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cccc2sc&nc12",
"old_substring": "Cc1csc6n1"
}
|
Can you make molecule O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(SC(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(SC(F)(F)F)n3n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C8(F)(F)F"
}
|
Can you make molecule O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CCCC(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CCCC(F)(F)F)n3n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C8(F)(F)F"
}
|
Can you make molecule O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CCCCC(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CCCCC(F)(F)F)n3n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C8(F)(F)F"
}
|
Can you make molecule O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)C(F)(F)F)n3n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C8(F)(F)F"
}
|
Can you make molecule O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CC(F)(F)C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(C(F)(F)F)n3n2)C1
|
O=C(Nc1ccccc1)[C@H]1CCCN(c2ccc3nnc(CC(F)(F)C(F)(F)F)n3n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C8(F)(F)F"
}
|
Can you make molecule CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1(CC(C)C)C[NH+](C[C@H]2CCCO[C@H]2[C@H]2CC=CCC2)C1
|
CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CCC1(CC(C)C)C[NH+](C[C@H]2CCCO[C@H]2[C@H]2CC=CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CC2)C1",
"old_substring": "[NH2+]23"
}
|
Can you make molecule CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C.C[NH+](C)C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CC(C)C.C[NH+](C)C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]&(C)C",
"old_substring": "[NH2+]23"
}
|
Can you make molecule CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC1(CC(C)C)C[NH+](C[C@H]2CCCO[C@H]2[C@H]2CC=CCC2)C1
|
CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CCCC1(CC(C)C)C[NH+](C[C@H]2CCCO[C@H]2[C@H]2CC=CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CCC2)C1",
"old_substring": "[NH2+]23"
}
|
Can you make molecule CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C.N#[N+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
CC(C)C.N#[N+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[N+]&#N",
"old_substring": "[NH2+]23"
}
|
Can you make molecule CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C1=CC[C@H]([C@@H]2OCCC[C@@H]2C[NH+]2CCCC2)CC1.CC(C)C
|
CC(C)C[NH2+]C[C@H]1CCCO[C@H]1[C@H]1CC=CCC1
|
C1=CC[C@H]([C@@H]2OCCC[C@@H]2C[NH+]2CCCC2)CC1.CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCC1",
"old_substring": "[NH2+]23"
}
|
Can you make molecule Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C#N)C(=O)COSC(=O)Cc2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COSC(=O)Cc2cc3c(s2)CC[C@@H](C)C3)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CCCC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CCCC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CC(C)(C)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CC(C)(C)c2cc3c(s2)CC[C@@H](C)C3)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CCC(C)(C)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)CCC(C)(C)c2cc3c(s2)CC[C@@H](C)C3)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc([C@@H](C#N)C(=O)COSC(=O)[C@@H](C)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)n1
|
Cc1csc([C@@H](C#N)C(=O)COSC(=O)[C@@H](C)c2cc3c(s2)CC[C@@H](C)C3)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+][C@@H]1CCC[C@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
|
CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+][C@@H]1CCC[C@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@@H]456"
}
|
Can you make molecule CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+][C@H]1CC[C@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
|
CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+][C@H]1CC[C@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@@H]456"
}
|
Can you make molecule CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+][C@H]1CC[C@@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
|
CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+][C@H]1CC[C@@](c2[nH]cc[nH+]2)([C@H]2CCOC3(CCSCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@@H]456"
}
|
Can you make molecule CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+][C@@H](CCCc1[nH]cc[nH+]1)C(C)(C)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+][C@@H](CCCc1[nH]cc[nH+]1)C(C)(C)[C@H]1CCOC2(CCSCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@@H]456"
}
|
Can you make molecule CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]C1C[C@H](c2[nH]cc[nH+]2)C[C@H]([C@H]2CCOC3(CCSCC3)C2)C1
|
CCC[NH2+][C@H](c1[nH]cc[nH+]1)[C@H]1CCOC2(CCSCC2)C1
|
CCC[NH2+]C1C[C@H](c2[nH]cc[nH+]2)C[C@H]([C@H]2CCOC3(CCSCC3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C[C@H]&C[C@H]&C1",
"old_substring": "[C@@H]456"
}
|
Can you make molecule CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1I
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c19ccc5cc1"
}
|
Can you make molecule CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)ccc1Br
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1
|
CCc1cc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c19ccc5cc1"
}
|
Can you make molecule CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1Cl
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c19ccc5cc1"
}
|
Can you make molecule CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)c1Br
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1
|
CCc1cccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c19ccc5cc1"
}
|
Can you make molecule CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)c1Cl
|
CCc1ccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)cc1
|
CCc1cccc(NC(=O)Cn2c(=O)n(Cc3ccco3)c(=O)c3sccc32)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c19ccc5cc1"
}
|
Can you make molecule Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1CC(=O)SNc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1CC(=O)SNc1ccc(Oc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C(=O)CCCC(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)CCCC(=O)Nc1ccc(Oc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C(C)(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(C)(C)CC(=O)Nc1ccc(Oc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C(C)(C)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(C)(C)CCC(=O)Nc1ccc(Oc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@H](C)C(=O)SNc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1C(=O)Nc1ccc(Oc2ccccc2)cc1
|
Cc1ccccc1[C@H](C)C(=O)SNc1ccc(Oc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)nc(-n2nc(C)cc2NSC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NSC(=O)CN2CCOC[C@H]2C2CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C4"
}
|
Can you make molecule Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CCCC(=O)N2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CCCC(=O)N2CCOC[C@H]2C2CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C4"
}
|
Can you make molecule Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CC(C)(C)N2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CC(C)(C)N2CCOC[C@H]2C2CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C4"
}
|
Can you make molecule Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)nc(-n2nc(C)cc2NC[S@+]([O-])CCCN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC[S@+]([O-])CCCN2CCOC[C@H]2C2CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C4"
}
|
Can you make molecule Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CCC(C)(C)N2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CN2CCOC[C@H]2C2CC2)n1
|
Cc1cc(C)nc(-n2nc(C)cc2NC(=O)CCC(C)(C)N2CCOC[C@H]2C2CC2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C4"
}
|
Can you make molecule CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(NSC(=O)CC2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NSC(=O)CC2(c3ccc(F)cc3F)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(NCC(=C=O)CC2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NCC(=C=O)CC2(c3ccc(F)cc3F)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(NC(=O)CCCC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)CCCC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(NC(=O)CC(C)(C)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)CC(C)(C)C2(c3ccc(F)cc3F)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(NC[S@+]([O-])CCCC2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1
|
CC1CC(NC[S@+]([O-])CCCC2(c3ccc(F)cc3F)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1Cl
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c13ccccc1"
}
|
Can you make molecule C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccc(I)cc1
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccc(I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c13ccccc1"
}
|
Can you make molecule C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](C)/N=C/C2C(=O)N(C(C)(C)C)C(=O)N=C2O)cc1I
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1
|
Cc1ccc([C@@H](C)/N=C/C2C(=O)N(C(C)(C)C)C(=O)N=C2O)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c13ccccc1"
}
|
Can you make molecule C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1cccc(Br)c1
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c13ccccc1"
}
|
Can you make molecule C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@@H](C)/N=C/C2C(=O)N(C(C)(C)C)C(=O)N=C2O)c1C
|
C[C@@H](/N=C/C1C(=O)N(C(C)(C)C)C(=O)N=C1O)c1ccccc1
|
Cc1cccc([C@@H](C)/N=C/C2C(=O)N(C(C)(C)C)C(=O)N=C2O)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c13ccccc1"
}
|
Can you make molecule CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C[C@@H]1CCCCN1C(=O)CC(C)(C)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)CC(C)(C)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C[C@@H]1CCCCN1C(=O)CCC(C)(C)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)CCC(C)(C)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C[C@@H]1CCCCN1C(=O)C[C@@H](Br)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1C(=O)C[C@@H](Br)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C[C@@H]1CCCCN1c1cc(C)n(NC2CCCCC2)c(=O)c1
|
CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1c1cc(C)n(NC2CCCCC2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C[C@@H]1CCCCN1c1c(C)n(NC2CCCCC2)ccc1=O
|
CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1
|
CC(=O)C[C@@H]1CCCCN1c1c(C)n(NC2CCCCC2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@](C)(NC(=O)CC(C)(C)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)CC(C)(C)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@](C)(NC(=O)CCC(C)(C)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)CCC(C)(C)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@](C)(Nc1c(C)n(C)n(NCc2cc(=O)[nH]c3ccccc23)c1=O)c1ccccc1
|
COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(Nc1c(C)n(C)n(NCc2cc(=O)[nH]c3ccccc23)c1=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
}
|
Can you make molecule COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@](C)(Nc1nn(NCc2cc(=O)[nH]c3ccccc23)c(C)cc1=O)c1ccccc1
|
COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(Nc1nn(NCc2cc(=O)[nH]c3ccccc23)c(C)cc1=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
}
|
Can you make molecule COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@](C)(NC(=O)C[C@@H](Br)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
|
COC[C@](C)(NC(=O)C[C@@H](Br)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
C=CSc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
CC(C)c1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC3"
}
|
Can you make molecule CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
C=CCCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1[nH+]c(CCCCl)c2c1N[C@@H]1COC[C@@]1(C)CN2
|
CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
Cn1[nH+]c(CCCCl)c2c1N[C@@H]1COC[C@@]1(C)CN2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1[nH+]c(CCCCS)c2c1N[C@@H]1COC[C@@]1(C)CN2
|
CCc1[nH+]n(C)c2c1NC[C@]1(C)COC[C@H]1N2
|
Cn1[nH+]c(CCCCS)c2c1N[C@@H]1COC[C@@]1(C)CN2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CCCCC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C14CC1"
}
|
Can you make molecule O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1SCCCS1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1SCCCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C14CC1"
}
|
Can you make molecule O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1SCSCS1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1SCSCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C14CC1"
}
|
Can you make molecule O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CCCCCC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C14CC1"
}
|
Can you make molecule O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CSCCSC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CC1
|
O=C([O-])COc1ccccc1/C=N/NC(=O)C1CSCCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "C14CC1"
}
|
Can you make molecule COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COCc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COCSc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(SC(C)=O)c2c1OCO2
|
COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(SC(C)=O)c2c1OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(C(=O)CS)c2c1OCO2
|
COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(C(=O)CS)c2c1OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(C(=O)CI)c2c1OCO2
|
COc1c(/C=N\NC(N)=S)c(C[C@@H](C)Cl)c(OC)c2c1OCO2
|
COc1c(C[C@@H](C)Cl)c(/C=N\NC(N)=S)c(C(=O)CI)c2c1OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C)c1-c1cc(CC(=O)SN[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(CC(=O)SN[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C)c1-c1cc(C(=O)CCCC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)CCCC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C)c1-c1cc(C(C)(C)CC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(C)(C)CC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C)c1-c1cc(C(C)(C)CCC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(C)(C)CCC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c(C)c1-c1cc([C@H](C)C(=O)SN[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc(C(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
|
Cc1nn(C)c(C)c1-c1cc([C@H](C)C(=O)SN[C@@H]2CC[C@H]([NH+](C)C)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SNc1cnn(Cc2ccccc2)c1)NC[C@@H]1CCCO1
|
O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1
|
O=C(/C=C/SNc1cnn(Cc2ccccc2)c1)NC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=NC[C@@H]2CCCO2)CCC1=Nc1cnn(Cc2ccccc2)c1
|
O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1
|
O=C1C(=NC[C@@H]2CCCO2)CCC1=Nc1cnn(Cc2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ONC[C@@H]1CCCO1)\c1ccc(Nc2cnn(Cc3ccccc3)c2)o1
|
O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1
|
C(=N/ONC[C@@H]1CCCO1)\c1ccc(Nc2cnn(Cc3ccccc3)c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC[C@@H]1CCCO1)NN=C1CCC(Nc2cnn(Cc3ccccc3)c2)CC1
|
O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1
|
O=C(NC[C@@H]1CCCO1)NN=C1CCC(Nc2cnn(Cc3ccccc3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC[C@@H]1CCCO1)C1=CC[C@H](Nc2cnn(Cc3ccccc3)c2)S1
|
O=C(NC[C@@H]1CCCO1)Nc1cnn(Cc2ccccc2)c1
|
O=C(NC[C@@H]1CCCO1)C1=CC[C@H](Nc2cnn(Cc3ccccc3)c2)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C34"
}
|
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