prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1I
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16ccc5cc1"
}
|
Can you make molecule COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cc(OC(F)(F)F)ccc1Br
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cc(OC(F)(F)F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16ccc5cc1"
}
|
Can you make molecule COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1Cl
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16ccc5cc1"
}
|
Can you make molecule COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cccc(OC(F)(F)F)c1Br
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cccc(OC(F)(F)F)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16ccc5cc1"
}
|
Can you make molecule COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cccc(OC(F)(F)F)c1Cl
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1ccc(OC(F)(F)F)cc1
|
COc1cn(-c2ccccc2)nc1C(=O)Nc1cccc(OC(F)(F)F)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16ccc5cc1"
}
|
Can you make molecule CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCBr
|
CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCc1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
C=CCCCCc1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCBr
|
CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCBr",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCS
|
CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCS
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCC&",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCCS
|
CC(C)c1ocnc1C[S@@+]([O-])[C@H](C)C(=O)NCC(F)(F)F
|
C[C@H](C(=O)NCC(F)(F)F)[S@+]([O-])Cc1ncoc1CCCCCCS
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCCC&",
"old_substring": "CC4C"
}
|
Can you make molecule C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](O)CC#CC[C@@H]1CN(c2cccnc2)C[C@H]1C
|
C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[C@@H]1CN(c2cccnc2)C[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CN&C[C@H]1C",
"old_substring": "[NH+]13CCC[C@H]4C1"
}
|
Can you make molecule C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](O)CC#CC[C@H]1CN(c2cccnc2)C[C@@H]1C
|
C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[C@H]1CN(c2cccnc2)C[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CN&C[C@@H]1C",
"old_substring": "[NH+]13CCC[C@H]4C1"
}
|
Can you make molecule C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](O)CC#CC[C@@]1(N)CC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[C@@]1(N)CC[C@H](c2cccnc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@]1&(N)CC[C@H]&C1",
"old_substring": "[NH+]13CCC[C@H]4C1"
}
|
Can you make molecule C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](O)CC#CC[C@H]1C=C[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[C@H]1C=C[C@H](c2cccnc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[NH+]13CCC[C@H]4C1"
}
|
Can you make molecule C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](O)CC#CC[C@H]1C=C[C@@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[NH+]1CCC[C@H](c2cccnc2)C1
|
C[C@H](O)CC#CC[C@H]1C=C[C@@H](c2cccnc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@@H]&C1",
"old_substring": "[NH+]13CCC[C@H]4C1"
}
|
Can you make molecule CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)N[C@H]1CCCN(CCC(CO)=NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CCC(CO)=NC2(c3ccccc3)CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C8C6=O"
}
|
Can you make molecule CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)N[C@H]1CCCN(C/C(C)=N\ONC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(C/C(C)=N\ONC2(c3ccccc3)CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C8C6=O"
}
|
Can you make molecule CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)N[C@H]1CCCN(C(CC)(CC)C(=O)CNC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(C(CC)(CC)C(=O)CNC2(c3ccccc3)CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C8C6=O"
}
|
Can you make molecule CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)N[C@H]1CCCN(SSC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(SSC(=O)NC2(c3ccccc3)CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C8C6=O"
}
|
Can you make molecule CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)N[C@H]1CCCN(C(CC)(CC)C(=O)CCNC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(CC(=O)NC2(c3ccccc3)CCC2)C1
|
CCOC(=O)N[C@H]1CCCN(C(CC)(CC)C(=O)CCNC2(c3ccccc3)CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C8C6=O"
}
|
Can you make molecule CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C[NH3+])CCN1CCOc2ccccc2C1
|
CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1
|
CC(C)(C[NH3+])CCN1CCOc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C[NH3+])CC3",
"old_substring": "CC[C@](C)([NH3+])C3=O"
}
|
Can you make molecule CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H]([NH3+])CN1CCOc2ccccc2C1
|
CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1
|
CCCC[C@H]([NH3+])CN1CCOc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]([NH3+])C3",
"old_substring": "CC[C@](C)([NH3+])C3=O"
}
|
Can you make molecule CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]([NH3+])CCN1CCOc2ccccc2C1
|
CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1
|
CCC[C@H]([NH3+])CCN1CCOc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]([NH3+])CC3",
"old_substring": "CC[C@](C)([NH3+])C3=O"
}
|
Can you make molecule CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[NH3+])N1CCOc2ccccc2C1
|
CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1
|
CC(C)C[C@@H](C[NH3+])N1CCOc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C[C@H]3C[NH3+]",
"old_substring": "CC[C@](C)([NH3+])C3=O"
}
|
Can you make molecule CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(C)C[C@@H]([NH3+])N1CCOc2ccccc2C1
|
CC[C@](C)([NH3+])C(=O)N1CCOc2ccccc2C1
|
C=C(C)C[C@@H]([NH3+])N1CCOc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(C)C[C@H]3[NH3+]",
"old_substring": "CC[C@](C)([NH3+])C3=O"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccccc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccccc1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c16cccnc1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccc(I)nc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccc(I)nc1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)nc1",
"old_substring": "c16cccnc1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cc3cnsc3s1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cc3cnsc3s1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cnsc2s1",
"old_substring": "c16cccnc1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCc3nc([C@H]4CCCCN4C(=O)c4cccc(F)c4)[nH]c(=O)c3C2)c(C)n1
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2
|
Cc1ccc(C[NH+]2CCc3nc([C@H]4CCCCN4C(=O)c4cccc(F)c4)[nH]c(=O)c3C2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)nc1C",
"old_substring": "c16cccnc1"
}
|
Can you make molecule O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccncc1Cl)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2
|
O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1ccncc1Cl)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c16cccnc1"
}
|
Can you make molecule O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)Cc2ccccc21
|
O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1
|
O=C1C(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)Cc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&Cc2ccccc21",
"old_substring": "O=C3C1=Cc2ccccc2OC1"
}
|
Can you make molecule O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(/N=C1/CCCN1)c1cccc(N=CC2=Cc3ccccc3OC2)c1
|
O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1
|
O=S(=O)(/N=C1/CCCN1)c1cccc(N=CC2=Cc3ccccc3OC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1=Cc2ccccc2OC1",
"old_substring": "O=C3C1=Cc2ccccc2OC1"
}
|
Can you make molecule O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)CCCc2ccccc21
|
O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1
|
O=C1C(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)CCCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCCc2ccccc21",
"old_substring": "O=C3C1=Cc2ccccc2OC1"
}
|
Can you make molecule O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CCSc2c(Nc3cccc(S(=O)(=O)/N=C4/CCCN4)c3)cccc21
|
O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1
|
O=C1CCSc2c(Nc3cccc(S(=O)(=O)/N=C4/CCCN4)c3)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1CCSc2c&cccc21",
"old_substring": "O=C3C1=Cc2ccccc2OC1"
}
|
Can you make molecule O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH][nH]c(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)c2ccccc12
|
O=C(Nc1cccc(S(=O)(=O)/N=C2/CCCN2)c1)C1=Cc2ccccc2OC1
|
O=c1[nH][nH]c(=Nc2cccc(S(=O)(=O)/N=C3/CCCN3)c2)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1NNC=&c2ccccc21",
"old_substring": "O=C3C1=Cc2ccccc2OC1"
}
|
Can you make molecule O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SOc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(/C=C/SOc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccccc1ON1CCC(=NON2CCN(Cc3ccc4c(c3)OCO4)CC2)CC1
|
O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
Fc1ccccc1ON1CCC(=NON2CCN(Cc3ccc4c(c3)OCO4)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(Oc2ccccc2F)CC1)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(NN=C1CCN(Oc2ccccc2F)CC1)N1CCN(Cc2ccc3c(c2)OCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(Oc2ccccc2F)CC1)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
O=C(NN=C1CCC(Oc2ccccc2F)CC1)N1CCN(Cc2ccc3c(c2)OCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ON1CCN(Cc2ccc3c(c2)OCO3)CC1)C(=O)SOc1ccccc1F
|
O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
|
C/C(=N\ON1CCN(Cc2ccc3c(c2)OCO3)CC1)C(=O)SOc1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C4C5"
}
|
Can you make molecule CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CBr)CN1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@@H](CBr)CN1CCC2(CC1)OC[C@H](C)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H](C&)CBr",
"old_substring": "CCC[C@H](C)C3=O"
}
|
Can you make molecule CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](Br)CCN1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](Br)CCN1CCC2(CC1)OC[C@H](C)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H](Br)CC&",
"old_substring": "CCC[C@H](C)C3=O"
}
|
Can you make molecule CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](Cl)CCCN1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@@H](Cl)CCCN1CCC2(CC1)OC[C@H](C)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@@H](Cl)CCC&",
"old_substring": "CCC[C@H](C)C3=O"
}
|
Can you make molecule CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H](Br)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCCC[C@H](Br)C(=O)N1CCC2(CC1)OC[C@H](C)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H](Br)C&=O",
"old_substring": "CCC[C@H](C)C3=O"
}
|
Can you make molecule CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](Br)CN1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](C)C(=O)N1CCC2(CC1)OC[C@H](C)O2
|
CCC[C@H](Br)CN1CCC2(CC1)OC[C@H](C)O2
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H](Br)C&",
"old_substring": "CCC[C@H](C)C3=O"
}
|
Can you make molecule CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNSC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNSC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C2(=O)C5"
}
|
Can you make molecule CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)CCCC(=O)N(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CCCC(=O)N(CC)C(=O)CC1([NH3+])CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C2(=O)C5"
}
|
Can you make molecule CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)CC(C)(C)N(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CC(C)(C)N(CC)C(=O)CC1([NH3+])CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)C5"
}
|
Can you make molecule CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC[S@+]([O-])CCCN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC[S@+]([O-])CCCN(CC)C(=O)CC1([NH3+])CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C2(=O)C5"
}
|
Can you make molecule CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)CCC(C)(C)N(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CN(CC)C(=O)CC1([NH3+])CCC1
|
CCNC(=O)CCC(C)(C)N(CC)C(=O)CC1([NH3+])CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)C5"
}
|
Can you make molecule Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(=S)n(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc21
|
Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21
|
Cn1c(=S)n(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1c(=S)n&c2ccccc21",
"old_substring": "Cn1cnc2cc4ccc21"
}
|
Can you make molecule Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc21
|
Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21
|
Cn1cc(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc&c2ccccc21",
"old_substring": "Cn1cnc2cc4ccc21"
}
|
Can you make molecule Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(OS(=O)(=O)/C=C/c2ccccc2)c2c(Cl)cccc21
|
Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21
|
Cn1nc(OS(=O)(=O)/C=C/c2ccccc2)c2c(Cl)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1nc&c2c(Cl)cccc21",
"old_substring": "Cn1cnc2cc4ccc21"
}
|
Can you make molecule Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc2c1=O
|
Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21
|
Cn1cc(OS(=O)(=O)/C=C/c2ccccc2)c2ccccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc&c2ccccc2c1=O",
"old_substring": "Cn1cnc2cc4ccc21"
}
|
Can you make molecule Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(OS(=O)(=O)/C=C/c2ccccc2)cc2c(F)cccc21
|
Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21
|
Cn1c(OS(=O)(=O)/C=C/c2ccccc2)cc2c(F)cccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1c&cc2c(F)cccc21",
"old_substring": "Cn1cnc2cc4ccc21"
}
|
Can you make molecule CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)C(=O)N1CCCCN1C(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)N1CCCCN1C(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)N1CCCCN1C&=O",
"old_substring": "C2(=O)CCC3=O"
}
|
Can you make molecule CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)C(=O)CC(C)(C)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CC(C)(C)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)CCC3=O"
}
|
Can you make molecule CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)C(=O)CCC(C)(C)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CCC(C)(C)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)CCC3=O"
}
|
Can you make molecule CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)C(=O)C1=C(NNc2ccccc2N2C[C@@H](C)O[C@@H](C)C2)CCS1
|
CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)C1=C(NNc2ccccc2N2C[C@@H](C)O[C@@H](C)C2)CCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=C(N&)CCS1",
"old_substring": "C2(=O)CCC3=O"
}
|
Can you make molecule CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)C(=O)[C@H](C)CCNc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)CCC(=O)Nc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
|
CCN(CC)C(=O)[C@H](C)CCNc1ccccc1N1C[C@@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@H](C)CC&",
"old_substring": "C2(=O)CCC3=O"
}
|
Can you make molecule CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CC(C)CC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
BrCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
BrCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
C=CCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
ClCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
ClCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
CCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
|
C=CCCCC[C@@H]1CN(C[C@@H]2CCCO2)c2ccccc2C[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC([NH3+])(CC)c1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
|
Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
CCC([NH3+])(CC)c1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC3([NH3+])CC",
"old_substring": "C3[NH3+]"
}
|
Can you make molecule Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC([NH3+])(CC)Cc1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
|
Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
CCC([NH3+])(CC)Cc1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C3C([NH3+])(CC)CC",
"old_substring": "C3[NH3+]"
}
|
Can you make molecule Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C[NH3+])(CCC)c1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
|
Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
CCCC(C[NH3+])(CCC)c1nnc(S[C@@H]2CCOC3(CCCC3)C2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC3(C[NH3+])CCC",
"old_substring": "C3[NH3+]"
}
|
Can you make molecule Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(CC(C)(C)[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
Cn1c(CC(C)(C)[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)([NH3+])C3",
"old_substring": "C3[NH3+]"
}
|
Can you make molecule Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(CCC(C)(C)C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
Cn1c(C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
|
Cn1c(CCC(C)(C)C[NH3+])nnc1S[C@@H]1CCOC2(CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C[NH3+])CC3",
"old_substring": "C3[NH3+]"
}
|
Can you make molecule CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
C=CSOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
C=CCCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COCCCCl)N1CCC[C@H]1c1cccc(Cl)c1
|
CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
O=C(COCCCCl)N1CCC[C@H]1c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COCCCCS)N1CCC[C@H]1c1cccc(Cl)c1
|
CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
O=C(COCCCCS)N1CCC[C@H]1c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COCCCBr)N1CCC[C@H]1c1cccc(Cl)c1
|
CCOCC(=O)N1CCC[C@H]1c1cccc(Cl)c1
|
O=C(COCCCBr)N1CCC[C@H]1c1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N[C@@H](CCC(C)(C)C)C(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@@H](CCC(C)(C)C)C(C)(C)C)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@H]16CCCC[C@H]18"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N[C@@H](C)CC(C)(C)CC(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@@H](C)CC(C)(C)CC(C)(C)C)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]16CCCC[C@H]18"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCC(C)(C)C)NC(=O)c1ccc(OC)c(OC)c1
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
|
CCCC[C@@H](CCC(C)(C)C)NC(=O)c1ccc(OC)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "[C@H]16CCCC[C@H]18"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N=CCC[C@@H](C)CC(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
|
COc1ccc(C(=O)N=CCC[C@@H](C)CC(C)(C)C)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "[C@H]16CCCC[C@H]18"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)N=CCC[C@H](C)CC(C)(C)C)cc1OC
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
|
COc1ccc(C(=O)N=CCC[C@H](C)CC(C)(C)C)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@H](C)C&",
"old_substring": "[C@H]16CCCC[C@H]18"
}
|
Can you make molecule CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1ccccc1Cl)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1Cl)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1ccc(I)cc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccc(I)cc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1ccc(C)c(I)c1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccc(C)c(I)c1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1cccc(Br)c1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1cccc(Br)c1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1cccc(C)c1C)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1ccccc1)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
|
CC[C@H](c1cccc(C)c1C)[S@+]([O-])CC(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC[C@H](O)c1nc2ccccc2n1CC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CCO)Cc1nc2ccccc2n1CC(C)C
|
CC[C@H](O)c1nc2ccccc2n1CC(C)C
|
CC[C@H](CCO)Cc1nc2ccccc2n1CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CCO",
"old_substring": "CC[C@@H]4O"
}
|
Can you make molecule CC[C@H](O)c1nc2ccccc2n1CC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)CC(=O)c1nc2ccccc2n1CC(C)C
|
CC[C@H](O)c1nc2ccccc2n1CC(C)C
|
CC[C@@H](C)CC(=O)c1nc2ccccc2n1CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C)CC&=O",
"old_substring": "CC[C@@H]4O"
}
|
Can you make molecule CC[C@H](O)c1nc2ccccc2n1CC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)C(=O)Cc1nc2ccccc2n1CC(C)C
|
CC[C@H](O)c1nc2ccccc2n1CC(C)C
|
CC[C@@H](C)C(=O)Cc1nc2ccccc2n1CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C)C(=O)C&",
"old_substring": "CC[C@@H]4O"
}
|
Can you make molecule CC[C@H](O)c1nc2ccccc2n1CC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CS)Cc1nc2ccccc2n1CC(C)C
|
CC[C@H](O)c1nc2ccccc2n1CC(C)C
|
CC[C@H](CS)Cc1nc2ccccc2n1CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CS",
"old_substring": "CC[C@@H]4O"
}
|
Can you make molecule CC[C@H](O)c1nc2ccccc2n1CC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)c1nc2ccccc2n1CC(C)C
|
CC[C@H](O)c1nc2ccccc2n1CC(C)C
|
CC[C@H](C)C(=O)c1nc2ccccc2n1CC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C)C&=O",
"old_substring": "CC[C@@H]4O"
}
|
Can you make molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](CCCCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](CCCCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C5C6"
}
|
Can you make molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](CCCCCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](CCCCCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5C6"
}
|
Can you make molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](C(C)C)C1CC(NC(=O)N[C@H]2CC(=O)N(C(C)(C)C)C2)C1
|
CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](C(C)C)C1CC(NC(=O)N[C@H]2CC(=O)N(C(C)(C)C)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C5C6"
}
|
Can you make molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](C(C)C)[C@@H](C)CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
|
CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](C(C)C)[C@@H](C)CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5C6"
}
|
Can you make molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](C(C)C)C1CCC(NC(=O)N[C@H]2CC(=O)N(C(C)(C)C)C2)CC1
|
CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C
|
CC[NH+](C(C)C)C1CCC(NC(=O)N[C@H]2CC(=O)N(C(C)(C)C)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C5C6"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(CO)=Nc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(CO)=Nc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C5C4=O"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2nccs2)ccc1OC/C(C)=N\ONc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OC/C(C)=N\ONc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C4=O"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(Oc1ccc(C(=O)Nc2nccs2)cc1OC)C(=O)CNc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1
|
CCC(CC)(Oc1ccc(C(=O)Nc2nccs2)cc1OC)C(=O)CNc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C4=O"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2nccs2)ccc1OSSC(=O)Nc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OSSC(=O)Nc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C4=O"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(Oc1ccc(C(=O)Nc2nccs2)cc1OC)C(=O)CCNc1ccc(F)cc1
|
COc1cc(C(=O)Nc2nccs2)ccc1OCC(=O)Nc1ccc(F)cc1
|
CCC(CC)(Oc1ccc(C(=O)Nc2nccs2)cc1OC)C(=O)CCNc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C4=O"
}
|
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